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Conserved domains on  [gi|555233550|ref|WP_023220365|]
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MULTISPECIES: type II toxin-antitoxin system HicA family toxin [Enterobacterales]

Protein Classification

type II toxin-antitoxin system HicA family toxin( domain architecture ID 10004385)

type II toxin-antitoxin (TA) system HicA family toxin similar to Escherichia coli HicA, part of the HicA-HicB TA module that plays a role in inducing cleavage of mRNA and tmRNA (transfer-mRNA), thereby preventing translation; the hicAB locus is transcribed in response to amino acid and carbon starvation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YcfA COG1724
Predicted RNA binding protein YcfA, dsRBD-like fold, HicA-like mRNA interferase family ...
 1-58 5.01e-09

Predicted RNA binding protein YcfA, dsRBD-like fold, HicA-like mRNA interferase family [General function prediction only];


:

Pssm-ID: 441330  Cd Length: 72  Bit Score: 46.77  E-value: 5.01e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 555233550  1 MKQSEFRRWLESQGVEVSNGT-NHLKLRYN--GNRSVMPRHPGAEIKEPLRKAILKQLGLK 58
Cdd:COG1724   7 MKGRELIKALEKLGFVLVRQKgSHHILKHPdkGRTVTVPRHPGKELPPGTLRSILKQAGLT 67
 
Name Accession Description Interval E-value
YcfA COG1724
Predicted RNA binding protein YcfA, dsRBD-like fold, HicA-like mRNA interferase family ...
 1-58 5.01e-09

Predicted RNA binding protein YcfA, dsRBD-like fold, HicA-like mRNA interferase family [General function prediction only];


Pssm-ID: 441330  Cd Length: 72  Bit Score: 46.77  E-value: 5.01e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 555233550  1 MKQSEFRRWLESQGVEVSNGT-NHLKLRYN--GNRSVMPRHPGAEIKEPLRKAILKQLGLK 58
Cdd:COG1724   7 MKGRELIKALEKLGFVLVRQKgSHHILKHPdkGRTVTVPRHPGKELPPGTLRSILKQAGLT 67
HicA_toxin pfam07927
HicA toxin of bacterial toxin-antitoxin,; HicA_toxin is a bacterial family of toxins that act ...
 4-56 1.45e-05

HicA toxin of bacterial toxin-antitoxin,; HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.


Pssm-ID: 462317  Cd Length: 56  Bit Score: 37.51  E-value: 1.45e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 555233550   4 SEFRRWLESQG-VEVSNGTNHLKLRYNGNRS--VMPRHPGAEIKEPLRKAILKQLG 56
Cdd:pfam07927  1 REVIKLLEKLGfELVRQKGSHVIFKHPDGRGivTVPPHPGKELKPGTLKSILKQAG 56
 
Name Accession Description Interval E-value
YcfA COG1724
Predicted RNA binding protein YcfA, dsRBD-like fold, HicA-like mRNA interferase family ...
 1-58 5.01e-09

Predicted RNA binding protein YcfA, dsRBD-like fold, HicA-like mRNA interferase family [General function prediction only];


Pssm-ID: 441330  Cd Length: 72  Bit Score: 46.77  E-value: 5.01e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 555233550  1 MKQSEFRRWLESQGVEVSNGT-NHLKLRYN--GNRSVMPRHPGAEIKEPLRKAILKQLGLK 58
Cdd:COG1724   7 MKGRELIKALEKLGFVLVRQKgSHHILKHPdkGRTVTVPRHPGKELPPGTLRSILKQAGLT 67
HicA_toxin pfam07927
HicA toxin of bacterial toxin-antitoxin,; HicA_toxin is a bacterial family of toxins that act ...
 4-56 1.45e-05

HicA toxin of bacterial toxin-antitoxin,; HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.


Pssm-ID: 462317  Cd Length: 56  Bit Score: 37.51  E-value: 1.45e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 555233550   4 SEFRRWLESQG-VEVSNGTNHLKLRYNGNRS--VMPRHPGAEIKEPLRKAILKQLG 56
Cdd:pfam07927  1 REVIKLLEKLGfELVRQKGSHVIFKHPDGRGivTVPPHPGKELKPGTLKSILKQAG 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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