|
Name |
Accession |
Description |
Interval |
E-value |
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
1-271 |
0e+00 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 553.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 1 MAFNFKTFAAVGALIGSLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGD 80
Cdd:PRK11063 1 MAFKFKTFAAVGALIGTLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 81 IDVNAFQHKPYLDQQIKDRGYKLVSVGNTFVYPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDG 160
Cdd:PRK11063 81 IDANAFQHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 161 VGLLPTSLDIVENPKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDA 240
Cdd:PRK11063 161 VGLLPTVLDIVENPKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEDKDSPYVNLIVAREDNKDA 240
|
250 260 270
....*....|....*....|....*....|.
gi 555204124 241 ENVKKFVQAYQSDEVYEAANKIFNGGAVKGW 271
Cdd:PRK11063 241 ENVKKFVQAYQSDEVYEAANKVFNGGAVKGW 271
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
14-271 |
5.05e-168 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 465.14 E-value: 5.05e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 14 LIGSLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLD 93
Cdd:TIGR00363 1 LASALVLTGCKQDKKDPLHIKVGVISGAEQQVAEVAAKVAKEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 94 QQIKDRGYKLVSVGNTFVYPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVEN 173
Cdd:TIGR00363 81 QDAKAKGYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGLLPTVLDIVEN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 174 PKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQAYQSD 253
Cdd:TIGR00363 161 PKKLNITELETSQLPRALDDPKVDLAVINTTYAGQVGLNPQDDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSE 240
|
250
....*....|....*...
gi 555204124 254 EVYEAANKIFNGGAVKGW 271
Cdd:TIGR00363 241 EVYQAAQKHFNGGAVKGW 258
|
|
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
6-271 |
1.78e-140 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 395.63 E-value: 1.78e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 6 KTFAAVGALIGSLALVGCGQDE-----KDPNHIKVGVIVGAEQQVAEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGD 80
Cdd:COG1464 3 KLLALLLALALALALAACGSSSaaaaaADKKTIKVGATPGPHAEILEVVKPELAKK-GIDLEIVEFTDYVQPNEALADGE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 81 IDVNAFQHKPYLDQQIKDRGYKLVSVGNTFVYPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDG 160
Cdd:COG1464 82 IDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKDG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 161 VGLLPTSLDIVENPKNLKIVELEAPQLPRSLDDaqIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDA 240
Cdd:COG1464 162 VGLLATVKDITENPKNLKFVELDAAQLPRSLDD--VDAAVINGNYALEAGLDPTKDALFLEDKDSPYANIIVVREDDKDD 239
|
250 260 270
....*....|....*....|....*....|.
gi 555204124 241 ENVKKFVQAYQSDEVYEAANKIFNGGAVKGW 271
Cdd:COG1464 240 PAIKKLVEAYQSDEVKKFIEEKYKGAVVPAW 270
|
|
| PBP2_lipoprotein_IlpA_like |
cd13598 |
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ... |
32-261 |
1.83e-136 |
|
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270316 Cd Length: 227 Bit Score: 384.01 E-value: 1.83e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 32 HIKVGVIVGAEQQVAEVAQKVAKEKYgLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFV 111
Cdd:cd13598 1 PIKVGVIRGPDAQIWEVVQKVAKEKG-LDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 112 YPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVENPKNLKIVELEAPQLPRSL 191
Cdd:cd13598 80 YPIGLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDGVGLLATVRDIAENPKKLKIVELDAGQLPRAL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 192 DDAqiALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANK 261
Cdd:cd13598 160 DDV--DLAAINTDYASKAGLTPARDAIAQEDKRSPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFALK 227
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
33-271 |
1.36e-122 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 349.25 E-value: 1.36e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 33 IKVGVIVGAEQQVAEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFVY 112
Cdd:pfam03180 1 LKVGATPGPHAEILEVAKPLLKKK-GLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 113 PIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVENPKNLKIVELEAPQLPRSLD 192
Cdd:pfam03180 80 PMGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGKGLLATVKDITENPKNLKIKELEAAQLPRALD 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 555204124 193 DaqIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANKIFNGGAVKGW 271
Cdd:pfam03180 160 D--VDAAVINTNYALEAGLNPKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPAW 236
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| metQ |
PRK11063 |
D-methionine ABC transporter substrate-binding protein MetQ; |
1-271 |
0e+00 |
|
D-methionine ABC transporter substrate-binding protein MetQ;
Pssm-ID: 182939 [Multi-domain] Cd Length: 271 Bit Score: 553.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 1 MAFNFKTFAAVGALIGSLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGD 80
Cdd:PRK11063 1 MAFKFKTFAAVGALIGTLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 81 IDVNAFQHKPYLDQQIKDRGYKLVSVGNTFVYPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDG 160
Cdd:PRK11063 81 IDANAFQHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 161 VGLLPTSLDIVENPKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDA 240
Cdd:PRK11063 161 VGLLPTVLDIVENPKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEDKDSPYVNLIVAREDNKDA 240
|
250 260 270
....*....|....*....|....*....|.
gi 555204124 241 ENVKKFVQAYQSDEVYEAANKIFNGGAVKGW 271
Cdd:PRK11063 241 ENVKKFVQAYQSDEVYEAANKVFNGGAVKGW 271
|
|
| TIGR00363 |
TIGR00363 |
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ... |
14-271 |
5.05e-168 |
|
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]
Pssm-ID: 129460 Cd Length: 258 Bit Score: 465.14 E-value: 5.05e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 14 LIGSLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLD 93
Cdd:TIGR00363 1 LASALVLTGCKQDKKDPLHIKVGVISGAEQQVAEVAAKVAKEKYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 94 QQIKDRGYKLVSVGNTFVYPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVEN 173
Cdd:TIGR00363 81 QDAKAKGYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGLLPTVLDIVEN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 174 PKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQAYQSD 253
Cdd:TIGR00363 161 PKKLNITELETSQLPRALDDPKVDLAVINTTYAGQVGLNPQDDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSE 240
|
250
....*....|....*...
gi 555204124 254 EVYEAANKIFNGGAVKGW 271
Cdd:TIGR00363 241 EVYQAAQKHFNGGAVKGW 258
|
|
| PRK09861 |
PRK09861 |
lipoprotein NlpA; |
9-271 |
1.36e-140 |
|
lipoprotein NlpA;
Pssm-ID: 182119 Cd Length: 272 Bit Score: 396.31 E-value: 1.36e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 9 AAVGALIGSLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGDIDVNAFQH 88
Cdd:PRK09861 10 AGAALLLAGILLAGCDQSSSDAKHIKVGVINGAEQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 89 KPYLDQQIKDRGYKLVSVGNTFVYPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSL 168
Cdd:PRK09861 90 RPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 169 DIVENPKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQ 248
Cdd:PRK09861 170 DITDNPRHLQIMELEGAQLPRVLDDPKVDVAIISTTYIQQTGLSPVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQ 249
|
250 260
....*....|....*....|...
gi 555204124 249 AYQSDEVYEAANKIFNGGAVKGW 271
Cdd:PRK09861 250 SYQSPEVAKAAETIFNGGAVPGW 272
|
|
| NlpA |
COG1464 |
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ... |
6-271 |
1.78e-140 |
|
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];
Pssm-ID: 441073 [Multi-domain] Cd Length: 270 Bit Score: 395.63 E-value: 1.78e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 6 KTFAAVGALIGSLALVGCGQDE-----KDPNHIKVGVIVGAEQQVAEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGD 80
Cdd:COG1464 3 KLLALLLALALALALAACGSSSaaaaaADKKTIKVGATPGPHAEILEVVKPELAKK-GIDLEIVEFTDYVQPNEALADGE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 81 IDVNAFQHKPYLDQQIKDRGYKLVSVGNTFVYPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDG 160
Cdd:COG1464 82 IDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKDG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 161 VGLLPTSLDIVENPKNLKIVELEAPQLPRSLDDaqIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDA 240
Cdd:COG1464 162 VGLLATVKDITENPKNLKFVELDAAQLPRSLDD--VDAAVINGNYALEAGLDPTKDALFLEDKDSPYANIIVVREDDKDD 239
|
250 260 270
....*....|....*....|....*....|.
gi 555204124 241 ENVKKFVQAYQSDEVYEAANKIFNGGAVKGW 271
Cdd:COG1464 240 PAIKKLVEAYQSDEVKKFIEEKYKGAVVPAW 270
|
|
| PBP2_lipoprotein_IlpA_like |
cd13598 |
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ... |
32-261 |
1.83e-136 |
|
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270316 Cd Length: 227 Bit Score: 384.01 E-value: 1.83e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 32 HIKVGVIVGAEQQVAEVAQKVAKEKYgLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFV 111
Cdd:cd13598 1 PIKVGVIRGPDAQIWEVVQKVAKEKG-LDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 112 YPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVENPKNLKIVELEAPQLPRSL 191
Cdd:cd13598 80 YPIGLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDGVGLLATVRDIAENPKKLKIVELDAGQLPRAL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 192 DDAqiALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANK 261
Cdd:cd13598 160 DDV--DLAAINTDYASKAGLTPARDAIAQEDKRSPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFALK 227
|
|
| Lipoprotein_9 |
pfam03180 |
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ... |
33-271 |
1.36e-122 |
|
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.
Pssm-ID: 427184 Cd Length: 236 Bit Score: 349.25 E-value: 1.36e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 33 IKVGVIVGAEQQVAEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFVY 112
Cdd:pfam03180 1 LKVGATPGPHAEILEVAKPLLKKK-GLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 113 PIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVENPKNLKIVELEAPQLPRSLD 192
Cdd:pfam03180 80 PMGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGKGLLATVKDITENPKNLKIKELEAAQLPRALD 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 555204124 193 DaqIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANKIFNGGAVKGW 271
Cdd:pfam03180 160 D--VDAAVINTNYALEAGLNPKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPAW 236
|
|
| PBP2_lipoprotein_MetQ_like |
cd13526 |
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ... |
32-261 |
1.53e-108 |
|
The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270244 Cd Length: 228 Bit Score: 313.10 E-value: 1.53e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 32 HIKVGVIVGAEQQVAEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFV 111
Cdd:cd13526 1 KLKIGVTAGPSADVVEAAKKEAKKK-GYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 112 YPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVENPKNLKIVELEAPQLPRSL 191
Cdd:cd13526 80 APIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGLFATVLDITENPKNLEIVEVDAAQLPRSL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 555204124 192 DDaqIALAVINTTYASQIGLTPAKDGIFVEGKE-SPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANK 261
Cdd:cd13526 160 DD--VDAAVINGNYAISAGLDPRKDAIFLEDSDaSPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
|
|
| PBP2_lipoprotein_Tp32 |
cd13597 |
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ... |
33-268 |
1.05e-92 |
|
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270315 Cd Length: 236 Bit Score: 273.38 E-value: 1.05e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 33 IKVGVIVGAEQQVAEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFVY 112
Cdd:cd13597 2 LKVGATPVPHAEILEFIKPELKKQ-GIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 113 PIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVENPKNLKIVELEAPQLPRSLD 192
Cdd:cd13597 81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGLTATVKDIVKNPKNLKFKELEAAQLPRSLD 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 555204124 193 DaqIALAVINTTYASQIGLTPAKDGIFVEGKE-SPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANKIFNGGAV 268
Cdd:cd13597 161 D--VDAAVINGNYALEAGLNPKKDALALEDKDnSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVV 235
|
|
| PBP2_lipoprotein_GmpC |
cd13596 |
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; ... |
33-261 |
3.72e-73 |
|
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; contains the type 2 periplasmic-binding protein fold; This group includes the membrane-associated lipoprotein-9 from Staphylococcus aureus that binds the dipeptide glycylmethionine (GlyMet). The lipoprotein-9 has both structural and sequential homology to the MetQ family of substrate-binding protein. The GlyMet binding protein belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270314 Cd Length: 230 Bit Score: 223.39 E-value: 3.72e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 33 IKVGVIvGAEQQVAEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFVY 112
Cdd:cd13596 2 VKIGVT-GEDTDIWDKIVEEAEEA-GIKLELVNFSDYSQPNKALNDGDIDLNAFQHYAYLVQYNSKNNADLTAIGDTVIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 113 PIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSLDIVENPKNLKIVELEAPQLPRSLD 192
Cdd:cd13596 80 PMGIYSKKITSVDELPDGAKIAIPNDPSNLSRALFILQAAGLIKLKKDAGDFPTVNDITENPKNLEIVPVDADQVYRALN 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 555204124 193 DAQIalAVINTTYASQIGLTPAKDGIFVEGKES----PYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANK 261
Cdd:cd13596 160 DVDA--AVINNTFALDAGLDPKKDAIFLEDPSSygskPYINLIAVREEDKDNPLYKKLVETYHDERVQKAVEE 230
|
|
| PBP2_lipoprotein_Gna1946 |
cd13599 |
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ... |
33-261 |
1.77e-67 |
|
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270317 Cd Length: 228 Bit Score: 208.79 E-value: 1.77e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 33 IKVGVIVGA-EQQVAEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFV 111
Cdd:cd13599 2 IVIGFTPGPyGDMVKNGVAPYLEKK-GYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 112 YPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSL-DIVENPKNLKIVELEAPQLPRS 190
Cdd:cd13599 81 PPMGLYSNKHKSLEEVKDGATVAIPNDPSNLARALVMLQDLGWITLKDNIDPLKASVnDIAENPKNIKIVELEAAQLPRS 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 555204124 191 LDDAQIalAVINTTYASQIGLTPaKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANK 261
Cdd:cd13599 161 LDDVDF--AAIQGNFAISSGIKL-TSALALEEMTDPYVNVVAVKTADKDKQFAKDVTAAYNSDAFKAYIHA 228
|
|
| PBP2_lipoprotein_like_1 |
cd13600 |
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ... |
33-255 |
5.20e-65 |
|
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.
Pssm-ID: 270318 Cd Length: 228 Bit Score: 202.56 E-value: 5.20e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 33 IKVGVIVGAEQQVAE-VAQKVAKEkyGLDVELVTFNDYVLPNEALSKGDIDVNAFQHKPYLDQQIKDRGYKLVSVGNTFV 111
Cdd:cd13600 2 LKVATNSGPMTEILEyIAAELAPD--GITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPIYH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 112 YPIAGYSKKIKSLDELQPGSQIAVPNDPTNLGRSLLLLQQVGLIKLKDGVGLLPTSL-DIVENPKNLKIVELEAPQLPRS 190
Cdd:cd13600 80 WAFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLaDIVTNPKNLKFTEVDLLALPRA 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 555204124 191 LDDaqIALAVINTTYASQIGLTPAKDGIFVEGKESPYVNLIVAREDNKDAENVKKFVQAYQSDEV 255
Cdd:cd13600 160 LDD--VDLAFGYPSYFDAAGLTPKDGILLEEPDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRV 222
|
|
| TauA |
COG0715 |
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion ... |
13-251 |
1.04e-13 |
|
ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component [Inorganic ion transport and metabolism];
Pssm-ID: 440479 [Multi-domain] Cd Length: 297 Bit Score: 69.65 E-value: 1.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 13 ALIGSLALVGCGQ--DEKDPNHIKVGVIVGAEQQVAEVAQkvAK---EKYGLDVELVTFNDYVLPNEALSKGDIDVNAFQ 87
Cdd:COG0715 2 AALAALALAACSAaaAAAEKVTLRLGWLPNTDHAPLYVAK--EKgyfKKEGLDVELVEFAGGAAALEALAAGQADFGVAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 88 HKPYLDQQikDRGYKLVSVGNTFVYP----IAGYSKKIKSLDELQpGSQIAVPNDPTNLGRSLLLLQQVGLiklkdgvgl 163
Cdd:COG0715 80 APPALAAR--AKGAPVKAVAALSQSGgnalVVRKDSGIKSLADLK-GKKVAVPGGSTSHYLLRALLAKAGL--------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 164 lptsldiveNPKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEGKESP--YVNLIVARED--NKD 239
Cdd:COG0715 148 ---------DPKDVEIVNLPPPDAVAALLAGQVDAAVVWEPFESQAEKKGGGRVLADSADLVPgyPGDVLVASEDflEEN 218
|
250
....*....|..
gi 555204124 240 AENVKKFVQAYQ 251
Cdd:COG0715 219 PEAVKAFLRALL 230
|
|
| PBP2_SsuA_like_6 |
cd13563 |
Putative substrate binding domain of sulfonate binding protein-like, a member of the type 2 ... |
55-250 |
3.98e-08 |
|
Putative substrate binding domain of sulfonate binding protein-like, a member of the type 2 periplasmic binding protein fold; This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270281 [Multi-domain] Cd Length: 208 Bit Score: 52.24 E-value: 3.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 55 EKYGLDVELVTFNDYVLPNEALSKGDIDVNAfqhkPYLDQQI----KDRGYKLV-----SVGNTFVypIAgySKKIKSLD 125
Cdd:cd13563 25 KKEGLDVELVWFESYSDSMAALASGQIDAAA----TTLDDALamaaKGVPVKIVlvldnSNGADGI--VA--KPGIKSIA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 126 ELQpGSQIAVPNDPTNLGRSLLLLQQVGLiklkdgvgllptsldiveNPKNLKIVELEAPQLPRSLDDAQIALAVINTTY 205
Cdd:cd13563 97 DLK-GKTVAVEEGSVSHFLLLNALEKAGL------------------TEKDVKIVNMTAGDAGAAFIAGQVDAAVTWEPW 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 555204124 206 ASQIGLTPaKDGIFVEGKESP--YVNLIVARED--NKDAENVKKFVQAY 250
Cdd:cd13563 158 LSNALKRG-KGKVLVSSADTPglIPDVLVVREDfiKKNPEAVKAVVKAW 205
|
|
| ProX |
COG2113 |
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport ... |
6-127 |
2.71e-06 |
|
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport and metabolism];
Pssm-ID: 441716 [Multi-domain] Cd Length: 297 Bit Score: 47.54 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 6 KTFAAVGALIGSLALVGCGQDEKDPNH---IKVGVIVGAEQQV-AEVAQKVAkEKYGLDVELVTFnDYVLPNEALSKGDI 81
Cdd:COG2113 3 KLLLLLLAAALALALAGCAAAAAAPGScktVTIADVGWTSATAtTAVAKQIL-EELGYEVELVEL-DVPVTYQGLANGDI 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 555204124 82 DVNA-----FQHKPYLDQ----QIKDRGYKLVSVGNTFVYPIAGYSKKIKSLDEL 127
Cdd:COG2113 81 DVFLeawlpTTHADYDEAygdgKVEDLGTNYEGAKQGLAVPKYVAEPGIKSIADL 135
|
|
| PBP2_ThiY_THI5_like_1 |
cd13652 |
Putative substrate binding domain of an ABC-type transporter similar to ThiY/THI5; the type 2 ... |
33-250 |
2.84e-04 |
|
Putative substrate binding domain of an ABC-type transporter similar to ThiY/THI5; the type 2 periplasmic binding protein fold; This subfamily is phylogenetically similar to ThiY, which is the periplasmic N-formyl-4-amino-5-(aminomethyl)-2-methylpyrimidine (FAMP) binding component of the ABC transport system (ThiXYZ). FAMP is imported into cell by the transporter, where it is then incorporated into the thiamin biosynthetic pathway. The closest structural homologs of ThiY are THI5, which is responsible for the synthesis of 4-amino-5-(hydroxymethyl)-2-methylpyrimidine phosphate (HMP-P) in the thiamin biosynthetic pathway of eukaryotes, and periplasmic binding proteins involved in alkanesulfonate/nitrate and bicarbonate transport. After binding the ligand, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ThiY/THI5 proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270370 [Multi-domain] Cd Length: 217 Bit Score: 41.22 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 33 IKVGVIVGAEQ-QVAEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGDIDVnAFQHKPYLDQQIKDRGYKLVSVGNTFV 111
Cdd:cd13652 4 VKFGQIPISDFaPVYIAAEKGYFKEEGLDVEITRFASGAEILAALASGQVDV-AGSSPGASLLGALARGADLKIVAEGLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 112 YPIaGYSKK---------IKSLDELQpGSQIAVPNdPTNLGRSLL--LLQQVGLiklkdgvgllptsldiveNPKNLKIV 180
Cdd:cd13652 83 TTP-GYGPFaivvradsgITSPADLV-GKKIAVST-LTNILEYTTnaYLKKNGL------------------DPDKVEFV 141
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555204124 181 ELEAPQLPRSLDDAQIALAVINTTYASQI----GLTPAKDGifvEGKESPYVNLIVAREDNK--DAENVKKFVQAY 250
Cdd:cd13652 142 EVAFPQMVPALENGNVDAAVLAEPFLSRArssgAKVVASDY---ADPDPHSQATMVFSADFAreNPEVVKKFLRAY 214
|
|
| OpuAC |
pfam04069 |
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ... |
32-128 |
7.58e-04 |
|
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).
Pssm-ID: 397954 [Multi-domain] Cd Length: 257 Bit Score: 40.00 E-value: 7.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 32 HIKVGVIVGAEQQV-AEVAQKVAKEKyGLDVELVTFNDYVLPNEALSKGDIDVNAF--------QHKPYLDQQIKDRGYK 102
Cdd:pfam04069 2 TIVIGSKNWTEQEIlANIAAQLLEAL-GYVVELVGLGSSAVLFAALASGDIDLYPEewtgttyeAYKKAVEEKLGLLVLG 80
|
90 100
....*....|....*....|....*....
gi 555204124 103 LVSVGNTFVYPIAGY---SKKIKSLDELQ 128
Cdd:pfam04069 81 PLGAGNTYGLAVPKYvaeKPGIKSISDLA 109
|
|
| NMT1 |
pfam09084 |
NMT1/THI5 like; This family contains the NMT1 and THI5 proteins. These proteins are proposed ... |
52-251 |
1.20e-03 |
|
NMT1/THI5 like; This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine.3]. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.
Pssm-ID: 430398 [Multi-domain] Cd Length: 216 Bit Score: 39.13 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 52 VAKEK-Y----GLDVELVTFNDYVLPNEALSKGDIDVnAFQHKPYLDQQiKDRGYKLVSVGNTFVYPIAGY----SKKIK 122
Cdd:pfam09084 9 VAQEKgYfkeeGLDVEIVEPADPSDATQLVASGKADF-GVSYQESVLLA-RAKGLPVVSVAALIQHPLSGVislkDSGIK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555204124 123 SLDELQpGSQIAVPNDPTNLGRSLLLLQQVGLiklkdgvgllptsldiveNPKNLKIVELEAPQLPRSLDDAQIAlAVIN 202
Cdd:pfam09084 87 SPKDLK-GKRIGYSGSPFEEALLKALLKKDGG------------------DPDDVTIVNVGGMNLFPALLTGKVD-AAIG 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 555204124 203 TTYASQiGLTPAKDGIFVE-------GKESPYVNLIVAREDN--KDAENVKKFVQAYQ 251
Cdd:pfam09084 147 GYYNWE-GVELKLEGVELNifaladyGVPDYYSLVLITNEAFlkENPELVRAFLRATL 203
|
|
| |
