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Conserved domains on  [gi|554765277|ref|WP_023190512|]
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MurR/RpiR family transcriptional regulator [Lactobacillus helveticus]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 11-172 3.29e-41

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 140.83  E-value: 3.29e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  11 ITENDNPTSVLFKLQTNLSKNIVDLGRSIDHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKS-S 89
Cdd:COG1737   91 LSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGdG 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  90 HIALEGITNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNSLFS 169
Cdd:COG1737  171 HLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSAFSSRVA 250


                 ...
gi 554765277 170 EMF 172
Cdd:COG1737  251 QLA 253
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 11-172 3.29e-41

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 140.83  E-value: 3.29e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  11 ITENDNPTSVLFKLQTNLSKNIVDLGRSIDHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKS-S 89
Cdd:COG1737   91 LSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGdG 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  90 HIALEGITNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNSLFS 169
Cdd:COG1737  171 HLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSAFSSRVA 250


                 ...
gi 554765277 170 EMF 172
Cdd:COG1737  251 QLA 253
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 42-172 7.35e-40

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 133.12  E-value: 7.35e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  42 KELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKSSHIALEGITNITKNDVLVIFSYSGMTQEPLLMA 121
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 554765277 122 KQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNSLFSEMF 172
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLA 131
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
39-166 1.28e-15

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 73.19  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  39 IDHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKSSHIALEGITNITKNDVLVIFSYSGMTQEPL 118
Cdd:PRK15482 120 FDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIV 199

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 554765277 119 LMAKQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNS 166
Cdd:PRK15482 200 LCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSMST 247
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 50-157 9.87e-14

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 65.01  E-value: 9.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277   50 LIDKARVVFIAGEGASGLAAEDFFDKLIR-SGKEVIFIKSSHIALEGITNITKNDVLVIFSYSGMTQEPLLMAKQARKNH 128
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEiGYKVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100
                  ....*....|....*....|....*....
gi 554765277  129 AKIVLITREKTSPLRQISDIVISLPTNEK 157
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVLYINAGPE 109
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 11-172 3.29e-41

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 140.83  E-value: 3.29e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  11 ITENDNPTSVLFKLQTNLSKNIVDLGRSIDHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKS-S 89
Cdd:COG1737   91 LSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGdG 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  90 HIALEGITNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNSLFS 169
Cdd:COG1737  171 HLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSAFSSRVA 250


                 ...
gi 554765277 170 EMF 172
Cdd:COG1737  251 QLA 253
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 42-172 7.35e-40

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 133.12  E-value: 7.35e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  42 KELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKSSHIALEGITNITKNDVLVIFSYSGMTQEPLLMA 121
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 554765277 122 KQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNSLFSEMF 172
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLA 131
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 23-167 1.62e-23

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 92.25  E-value: 1.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  23 KLQTNLSKNIVDLGRSIDHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVifikssHIALEGIT-NITK 101
Cdd:cd05005    2 EYLSLILEEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNV------YVVGETTTpAIGP 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 554765277 102 NDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNSL 167
Cdd:cd05005   76 GDLLIAISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAATKDDHGGEHKSI 141
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
39-166 1.28e-15

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 73.19  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  39 IDHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKSSHIALEGITNITKNDVLVIFSYSGMTQEPL 118
Cdd:PRK15482 120 FDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIV 199

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 554765277 119 LMAKQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNS 166
Cdd:PRK15482 200 LCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSMST 247
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
11-159 8.78e-15

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 70.94  E-value: 8.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  11 ITENDNPTSVLFKLqTNLSKNIVDLGRSI-DHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKSS 89
Cdd:PRK11337  97 LSFDDAPQDVVNKV-FNTSLQAIEETQSIlDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDA 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  90 HIALEGITNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLL 159
Cdd:PRK11337 176 HIMLMSAALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVICSTAQGSPL 245
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 50-157 9.87e-14

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 65.01  E-value: 9.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277   50 LIDKARVVFIAGEGASGLAAEDFFDKLIR-SGKEVIFIKSSHIALEGITNITKNDVLVIFSYSGMTQEPLLMAKQARKNH 128
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEiGYKVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100
                  ....*....|....*....|....*....
gi 554765277  129 AKIVLITREKTSPLRQISDIVISLPTNEK 157
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVLYINAGPE 109
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
39-171 6.54e-13

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 65.56  E-value: 6.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  39 IDHKE-LKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKSSHIALEGITNITKNDVLVIFSYSGMTQEP 117
Cdd:PRK11557 112 VNSEEkLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGINAVAERDMHALLATVQALSPDDLLLAISYSGERREL 191

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 554765277 118 LLMAKQARKNHAKIVLITREKTSPLRQISDIVISLPTNEKLLRFGAVNSLFSEM 171
Cdd:PRK11557 192 NLAADEALRVGAKVLAITGFTPNALQQRASHCLYTIAEEQATRSAAISSTHAQG 245
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 99-153 1.01e-10

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 57.17  E-value: 1.01e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 554765277  99 ITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLP 153
Cdd:cd05014   45 VTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNSTLAKLSDVVLDLP 99
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 11-156 1.45e-10

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 59.24  E-value: 1.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  11 ITENDNPTSVLFKLQTNLSKNIVDLGRSIDHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFikSSH 90
Cdd:PRK11302  85 VEEDDSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVY--FDD 162

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 554765277  91 IALEGIT--NITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLITrEKTSPLRQISDIVISLPTNE 156
Cdd:PRK11302 163 IVMQRMScmNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAIT-SAGSPLAREATLALTLDVPE 229
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
15-155 7.10e-10

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 57.62  E-value: 7.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  15 DNPTSVLFKLQTNLSKNIVDLGRSIDHKELKQAVELIDKARVVFIAGEGASGLAAEDFFDKLIRSGKEVIFIKSSHIALE 94
Cdd:PRK14101 429 DTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDLYMQAA 508

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 554765277  95 GITNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLITREKTsPLRQISDIVisLPTN 155
Cdd:PRK14101 509 SAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNT-PLAKRATVA--LETD 566
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 57-135 7.74e-08

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 48.14  E-value: 7.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  57 VFIAGEGASGLAAEDFFDKLIRS-GKEVIFIKSSHIAL-EGITNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLI 134
Cdd:cd04795    1 IFVIGIGGSGAIAAYFALELLELtGIEVVALIATELEHaSLLSLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80


                 .
gi 554765277 135 T 135
Cdd:cd04795   81 T 81
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 32-153 1.17e-07

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 50.75  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  32 IVDLGRSIDHkELKQAVELID--KARVVfIAGEGASGLAAEDFFDKLIRSGKEVIFI---KSSHIALeGItnITKNDVLV 106
Cdd:COG0794   22 LAALAERLDE-SFEKAVELILncKGRVV-VTGMGKSGHIARKIAATLASTGTPAFFLhpaEASHGDL-GM--ITPGDVVI 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 554765277 107 IFSYSGMTQEPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLP 153
Cdd:COG0794   97 AISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDLP 143
PRK02947 PRK02947
sugar isomerase domain-containing protein;
41-150 2.16e-07

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 49.48  E-value: 2.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  41 HKELKQAVEL----IDKARVVFIAGEGASGLAAEDFFdklIRSGKEVIF--------------IKSSHI-ALEGI----- 96
Cdd:PRK02947  23 AEAIEKAADLiadsIRNGGLIYVFGTGHSHILAEEVF---YRAGGLAPVnpilepslmlhegaVASSYLeRVEGYakail 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 554765277  97 --TNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLIT----REKTSP-------LRQISDIVI 150
Cdd:PRK02947 100 drYDIRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTslaySASVASrhssgkrLAEVADVVL 166
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
 57-136 6.23e-07

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 46.49  E-value: 6.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  57 VFIAGEGASGLA---AEDFFdkLIRSGKEVIFIKSSHIAlegiTNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVL 133
Cdd:cd05017    2 IVILGMGGSGIGgdlLESLL--LDEAKIPVYVVKDYTLP----AFVDRKTLVIAVSYSGNTEETLSAVEQAKERGAKIVA 75


                 ...
gi 554765277 134 ITR 136
Cdd:cd05017   76 ITS 78
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
 55-150 2.67e-06

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 44.87  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  55 RVVFIA--GEGASGLAAEDFFDKliRSGKEVIFIKSSHIALEGITNITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIV 132
Cdd:cd05710    1 NVFFVGcgGSLADMYPAKYFLKK--ESKLPVFVYNAAEFLHTGPKRLTEKSVVILASHSGNTKETVAAAKFAKEKGATVI 78

                         90
                 ....*....|....*...
gi 554765277 133 LITREKTSPLRQISDIVI 150
Cdd:cd05710   79 GLTDDEDSPLAKLADYVI 96
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
 47-154 1.70e-05

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 44.05  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  47 AVEL-----IDKARVVF-IAGeGASGLA-----AEDFFDKLIRsgkevifiksshiALEGItNITKNDVLVIFSYSGMTQ 115
Cdd:cd05007   68 ASELpptfgTPPERVVGlIAG-GEPALTravegAEDDEEAGAA-------------DLQAI-NLTERDVVIGIAASGRTP 132

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 554765277 116 EPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLPT 154
Cdd:cd05007  133 YVLGALRYARARGALTIGIACNPGSPLLQLADIAIALIT 171
PRK08674 PRK08674
bifunctional phosphoglucose/phosphomannose isomerase; Validated
 48-135 1.21e-04

bifunctional phosphoglucose/phosphomannose isomerase; Validated


Pssm-ID: 181536 [Multi-domain]  Cd Length: 337  Bit Score: 41.89  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  48 VELIDKARVVFIAGEGASGLAAeDFFDKLIRSG--KEVIFIKSSHIALEgitnITKNDVLVIFSYSGMTQEPLLMAKQAR 125
Cdd:PRK08674  28 EEDLEKIDNIVISGMGGSGIGG-DLLRILLFDElkVPVFVNRDYTLPAF----VDEKTLVIAVSYSGNTEETLSAVEQAL 102

                         90
                 ....*....|
gi 554765277 126 KNHAKIVLIT 135
Cdd:PRK08674 103 KRGAKIIAIT 112
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 44-135 1.44e-04

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 40.27  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277   44 LKQAVELI----DKARVVFIAGEGASGLAAEDFFDKLI-RSGKEVIFI------------KSSHIA-LEGI-------TN 98
Cdd:pfam13580  21 IEKAADLIaaslANGGKVYAFGTGHSAAPAEELFARAGgLAGFEPILLpalalhtdasatISTALErDEGYarqilalYP 100

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 554765277   99 ITKNDVLVIFSYSGMTQEPLLMAKQARKNHAKIVLIT 135
Cdd:pfam13580 101 GRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
murQ PRK05441
N-acetylmuramic acid-6-phosphate etherase; Reviewed
 47-154 2.55e-04

N-acetylmuramic acid-6-phosphate etherase; Reviewed


Pssm-ID: 235467 [Multi-domain]  Cd Length: 299  Bit Score: 40.92  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554765277  47 AVEL-----IDKARVVF-IAGeGASGLA-----AEDFFDklirSGKEvifiksshiALEGItNITKNDVLVIFSYSGMTQ 115
Cdd:PRK05441  81 ASECpptfgVPPELVVGlIAG-GEKALTkavegAEDDAE----LGAA---------DLKAI-NLTAKDVVVGIAASGRTP 145

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 554765277 116 EPLLMAKQARKNHAKIVLITREKTSPLRQISDIVISLPT 154
Cdd:PRK05441 146 YVIGALEYARERGALTIGISCNPGSPLSKEADIAIEVVV 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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