|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
5-170 |
2.32e-67 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 209.91 E-value: 2.32e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 5 KSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNL--------GEEGEFCYSRCSNPTRYAYETALAELEGGIYATATA 76
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAealaarfaGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 77 SGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLEL 155
Cdd:COG0626 81 SGMAAiSAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARF-GIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170
....*....|....*
gi 553371607 156 VDIEAVCQVAKSRGI 170
Cdd:COG0626 160 VDIAAIAAIAHAAGA 174
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
8-173 |
3.01e-61 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 193.99 E-value: 3.01e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 8 ATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATAL-IL 86
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAaIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 87 ELLPKDSHVLVMKGVYGGTYRLFERLRKQtSGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAK 166
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPR-FGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAK 159
|
....*..
gi 553371607 167 SRGIMSC 173
Cdd:pfam01053 160 KHGILVV 166
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
23-170 |
1.14e-49 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 163.91 E-value: 1.14e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 23 NAIFPPITTASSFIQPNLGE--------EGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAA-TALILELLPKDS 93
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEaadlfalrEGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAiSTVLLALLKAGD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 553371607 94 HVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAKSRGI 170
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKL-GIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGA 156
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
1-169 |
4.87e-49 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 162.63 E-value: 4.87e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMA 80
Cdd:PRK08064 1 MAMSYSIDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 81 ATALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEA 160
Cdd:PRK08064 81 AISTAFLLLSKGDHVLISEDVYGGTYRMITEVLSRF-GIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRG 159
|
....*....
gi 553371607 161 VCQVAKSRG 169
Cdd:PRK08064 160 VVKLAKAIG 168
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
1-169 |
2.27e-47 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 158.27 E-value: 2.27e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGE-EGEFCYSRCSNPTRYAYETALAELEGGIYATATASGM 79
Cdd:PRK07811 7 HHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 80 AATALILE--LLPKDsHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVD 157
Cdd:PRK07811 87 AATDCLLRavLRPGD-HIVIPNDAYGGTFRLIDKVFTRW-GVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITD 164
|
170
....*....|..
gi 553371607 158 IEAVCQVAKSRG 169
Cdd:PRK07811 165 IAALAELAHDAG 176
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
3-171 |
3.27e-45 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 152.16 E-value: 3.27e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 3 KSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAAT 82
Cdd:PRK08247 1 QMSTIETKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 83 ALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVC 162
Cdd:PRK08247 81 QLVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKW-NVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIA 159
|
....*....
gi 553371607 163 QVAKSRGIM 171
Cdd:PRK08247 160 KIAKKHGLL 168
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
9-171 |
2.36e-44 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 150.26 E-value: 2.36e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 9 TLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATALILEL 88
Cdd:PRK07671 5 TKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMML 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 89 LPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAKSR 168
Cdd:PRK07671 85 FSSGDHVILTDDVYGGTYRVMTKVLNRF-GIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEK 163
|
...
gi 553371607 169 GIM 171
Cdd:PRK07671 164 GLL 166
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-170 |
1.03e-39 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 139.01 E-value: 1.03e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSK-SIATLVIHAGDQVDRGNNAIFPPI--TT----------ASSFiqpNLGEEGeFCYSRCSNPTRYAYETALAELE 67
Cdd:COG2873 1 MTEKKyGFETLALHAGQEPDPTTGARAVPIyqTTsyvfddaehaADLF---ALKEPG-NIYTRIMNPTTDVLEKRIAALE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 68 GGIYATATASGMAATAL-ILELLPKDSHVLVMKGVYGGTYRLFER-LRKQtsGTTFSYVDLNDLASVERHIQENTGLIWI 145
Cdd:COG2873 77 GGVAALATASGQAAITLaILNLAEAGDHIVASSSLYGGTYNLFAHtLPRL--GIEVRFVDPDDPEAFEAAIDPNTKAIFG 154
|
170 180
....*....|....*....|....*
gi 553371607 146 ETPTNPLLELVDIEAVCQVAKSRGI 170
Cdd:COG2873 155 ETIGNPALDVLDIEAIAEIAHEHGV 179
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
6-172 |
2.89e-39 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 136.95 E-value: 2.89e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 6 SIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATALI 85
Cdd:PRK06176 2 RMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 86 LELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVA 165
Cdd:PRK06176 82 FSLFQSGDHVLLGDDVYGGTFRLFDKVLVKN-GLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA 160
|
....*..
gi 553371607 166 KSRGIMS 172
Cdd:PRK06176 161 KDHGLLT 167
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
4-172 |
8.24e-36 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 127.99 E-value: 8.24e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 4 SKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATA 83
Cdd:TIGR02080 1 TRKQATIAVRSGLNSDTQYGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 84 LI-LELLPKDSHVLVMKGVYGGTYRLFERLRKQTSgTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVC 162
Cdd:TIGR02080 81 LVtTALLGPDDLLVAPHDCYGGTYRLLNALAKKGC-FRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKIC 159
|
170
....*....|
gi 553371607 163 QVAKSRGIMS 172
Cdd:TIGR02080 160 HLAKAVGAVV 169
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
7-169 |
3.52e-34 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 123.40 E-value: 3.52e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 7 IATLVIHAGDQVDRgNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATALIL 86
Cdd:TIGR01329 1 LSTLLVNTDNKNDP-YDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 87 ELLPKDSHVLVMKGVYGGTYRLFERLrKQTSGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAK 166
Cdd:TIGR01329 80 RLLNNGDEIIAGDDLYGGTDRLLTQV-VPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAH 158
|
...
gi 553371607 167 SRG 169
Cdd:TIGR01329 159 AQN 161
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
1-169 |
3.79e-34 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 123.39 E-value: 3.79e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMA 80
Cdd:PRK07269 1 MSKDLHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 81 ATALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTSgttFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEA 160
Cdd:PRK07269 81 AIVLAFSVFPVGSKVVAVRDLYGGSFRWFNQQEKEGR---FHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEK 157
|
....*....
gi 553371607 161 VCQVAKSRG 169
Cdd:PRK07269 158 VAKLAHAKG 166
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
1-171 |
9.84e-34 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 122.42 E-value: 9.84e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSKSIATLVIHAGDQVDRGN---NAIFPpittASSFIQPN--------LGEEGEFCYSRCSNPTRYAYETALAELEGG 69
Cdd:PRK08133 1 DDDSLGFDTLAVRAGQLRSPFGehsEALFL----TSSFVFESaaeaaarfAGEEPGNIYSRFTNPTVTMFQERLAALEGA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 70 IYATATASGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETP 148
Cdd:PRK08133 77 EACVATASGMAAiLAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARF-GIETTFVDLTDLDAWRAAVRPNTKLFFLETP 155
|
170 180
....*....|....*....|...
gi 553371607 149 TNPLLELVDIEAVCQVAKSRGIM 171
Cdd:PRK08133 156 SNPLTELADIAALAEIAHAAGAL 178
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
3-171 |
1.53e-33 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 121.87 E-value: 1.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 3 KSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNL--------GEEGEFCYSRCSNPTRYAYETALAELEGGIYATA 74
Cdd:PRK06767 2 KKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAqqgeasfaGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 75 TASGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTSGTTfSYVDLNDLASVERHIQENTGLIWIETPTNPLL 153
Cdd:PRK06767 82 FGSGMAAiSATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITH-SFCDMETEADIENKIRPNTKLIFVETPINPTM 160
|
170
....*....|....*...
gi 553371607 154 ELVDIEAVCQVAKSRGIM 171
Cdd:PRK06767 161 KLIDLKQVIRVAKRNGLL 178
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
8-170 |
4.17e-33 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 121.31 E-value: 4.17e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 8 ATLVIHAGDQVDRGNNAIFPPI--TTASSFIQP-------NLGEEGEFcYSRCSNPTRYAYETALAELEGGIYATATASG 78
Cdd:TIGR01326 3 ETLQLHAGQEPDPTTGSRAVPIyqTTSYVFDSTehaaalfGLQEPGNI-YSRLMNPTTDVLEQRIAALEGGVAALAVASG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 79 MAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVD 157
Cdd:TIGR01326 82 QAAiTYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRL-GIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLD 160
|
170
....*....|...
gi 553371607 158 IEAVCQVAKSRGI 170
Cdd:TIGR01326 161 IEAIAEVAHRHGI 173
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
1-169 |
1.37e-32 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 119.61 E-value: 1.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSkSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMA 80
Cdd:PRK08861 1 MS-TRKPATIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 81 ATALILE-LLPKDSHVLVMKGVYGGTYRLFE-RLRKQTSGTTFsyVDLNDLASVERHIQENTGLIWIETPTNPLLELVDI 158
Cdd:PRK08861 80 ALNLWVSaLLGPDDLIVAPHDCYGGTYRLFNtRANKGDFKVQF--VDQSDAAALDAALAKKPKLILLETPSNPLVRVVDI 157
|
170
....*....|.
gi 553371607 159 EAVCQVAKSRG 169
Cdd:PRK08861 158 AELCQKAKAVG 168
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
8-172 |
6.14e-30 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 112.30 E-value: 6.14e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 8 ATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATALILE 87
Cdd:PRK08045 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 88 LLPKDSHVLVM-KGVYGGTYRLFERLRKQTSgTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAK 166
Cdd:PRK08045 86 VFLKPGDLLVApHDCYGGSYRLFDSLAKRGC-YRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAR 164
|
....*.
gi 553371607 167 SRGIMS 172
Cdd:PRK08045 165 EAGAVS 170
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
6-171 |
9.03e-30 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 112.39 E-value: 9.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 6 SIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATALI 85
Cdd:PRK08776 12 SAATAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 86 LELL--PKDSHVlVMKGVYGGTYRLFERLRKQTSGTTFSyVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQ 163
Cdd:PRK08776 92 LNALlqPGDTLV-VPHDAYGGSWRLFNALAKKGHFALIT-ADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIE 169
|
....*...
gi 553371607 164 VAKSRGIM 171
Cdd:PRK08776 170 AAHKVGAL 177
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
1-169 |
1.96e-29 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 111.43 E-value: 1.96e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSKSIATLVIHAG-DQVDRGNnAIFPPITTASSFIQPNL--------GEEGEFCYSRCSNPTRYAYETALAELEGGIY 71
Cdd:PRK07503 4 SHNNTGFSTRAIHHGyDPLDHGG-ALVPPVYLTATFAFPTAeygaecfaGEEEGHFYSRISNPTLALLEQRMASLEGGEA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 72 ATATASGMAA-TALILELLPKDSHVLVMKGVYGGTYRLferLRKQTS--GTTFSYVDLNDLASVERHIQENTGLIWIETP 148
Cdd:PRK07503 83 AVALASGMGAiTATLWTLLRPGDEVIVDQTLYGCTFAF---LHHGLGefGVTVRHVDLTDPAALKAAISDKTRMVYFETP 159
|
170 180
....*....|....*....|.
gi 553371607 149 TNPLLELVDIEAVCQVAKSRG 169
Cdd:PRK07503 160 ANPNMRLVDIAAVAEIAHGAG 180
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
8-169 |
3.96e-28 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 107.62 E-value: 3.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 8 ATLVIHAG---DQVDRGNNAIFppitTASSFIQPNL--------GEEGEFCYSRCSNPTRYAYETALAELEGGIYATATA 76
Cdd:TIGR01325 1 ATLAVRGGmlrSGFEETAEALY----LTSGYVYDSAavaakrfaGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 77 SGMAAT-ALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLEL 155
Cdd:TIGR01325 77 SGMAAIfAALMALLGAGDHVVASRSLFGSCFVVCSEILPRF-GVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQEL 155
|
170
....*....|....
gi 553371607 156 VDIEAVCQVAKSRG 169
Cdd:TIGR01325 156 VDIAAVAELAHAAG 169
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
6-171 |
1.85e-26 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 103.96 E-value: 1.85e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 6 SIATLVIHAGDQVDRgNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATALI 85
Cdd:PLN02509 86 SVSTLLVNLDNKFDP-FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 86 LELLPKDSHVLVMKGVYGGTYRLFERLRKQtSGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVA 165
Cdd:PLN02509 165 THLIKNGEEIVAGDDVYGGSDRLLSQVVPR-SGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMA 243
|
....*.
gi 553371607 166 KSRGIM 171
Cdd:PLN02509 244 HAQGAL 249
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
3-165 |
8.47e-26 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 101.44 E-value: 8.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 3 KSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNL--------GEEGEFCYSRCSNPTRYAYETALAELEGGIYATA 74
Cdd:PRK06234 5 KKMGFATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAeqggrrfaGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 75 TASGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFER-LRKQtsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPL 152
Cdd:PRK06234 85 AASGMGAiSSSLWSALKAGDHVVASDTLYGCTFALLNHgLTRY--GVEVTFVDTSNLEEVRNALKANTKVVYLETPANPT 162
|
170
....*....|...
gi 553371607 153 LELVDIEAVCQVA 165
Cdd:PRK06234 163 LKVTDIKAISNIA 175
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
9-170 |
4.67e-25 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 99.81 E-value: 4.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 9 TLVIHAGDQVDRGNNAIFPPITTASSFIQP---------NLGEEGEFcYSRCSNPTRYAYETALAELEGGIYATATASGM 79
Cdd:PRK08134 11 TLALHAGAAPDPATGARAVPIHLTTSFVFRdsdhaaalfNLERAGHV-YSRISNPTVAVLEERVAALEGGVGAIATASGQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 80 AATAL-ILELLPKDSHVLVMKGVYGGTYRLFE-RLRKQTSGTTFsyVDLNDLASVERHIQENTGLIWIETPTNPLLELVD 157
Cdd:PRK08134 90 AALHLaIATLMGAGSHIVASSALYGGSHNLLHyTLRRFGIETTF--VKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLD 167
|
170
....*....|...
gi 553371607 158 IEAVCQVAKSRGI 170
Cdd:PRK08134 168 IPTVAAIAHEAGV 180
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
41-169 |
8.88e-25 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 98.67 E-value: 8.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 41 GEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGT 119
Cdd:PRK07504 52 GEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAvTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRY-GI 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 553371607 120 TFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAKSRG 169
Cdd:PRK07504 131 ESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAG 180
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
6-170 |
9.94e-25 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 99.06 E-value: 9.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 6 SIATLVIHAGDQVDRGNNAIFPPITTASSFIQPN---------LGEEGEFcYSRCSNPTRYAYETALAELEGGIYATATA 76
Cdd:PRK07812 13 SFETKQIHAGQTPDPATNARALPIYQTTSYTFDDtdhaaalfgLAEPGNI-YTRIMNPTQDVVEQRIAALEGGVAALLLA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 77 SGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFE-RLRKQtsGTTFSYV-DLNDLASVERHIQENTGLIWIETPTNPLL 153
Cdd:PRK07812 92 SGQAAeTFAILNLAGAGDHIVSSPRLYGGTYNLFHyTLPKL--GIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQI 169
|
170
....*....|....*..
gi 553371607 154 ELVDIEAVCQVAKSRGI 170
Cdd:PRK07812 170 DVLDIPGVAEVAHEAGV 186
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
6-165 |
7.41e-24 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 96.48 E-value: 7.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 6 SIATLVIHAGDQVDRGNNAIFPPITTASSFI---------QPNLGEEGEFcYSRCSNPTRYAYETALAELEGGIYATATA 76
Cdd:PRK05613 13 GFETRSIHAGQSVDSDTSARNLPIYQTTSYVfdsaehakqRFALEDLGPI-YSRLTNPTVEALENRIASLEGGVHAVAFA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 77 SGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYV-DLNDLASVERHIQENTGLIWIETPTNPLLE 154
Cdd:PRK05613 92 SGQAAeTAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRL-GIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQAD 170
|
170
....*....|.
gi 553371607 155 LVDIEAVCQVA 165
Cdd:PRK05613 171 VLDIPAVAEVA 181
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
1-170 |
1.32e-23 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 95.55 E-value: 1.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPN---------LGEEGEFcYSRCSNPTRYAYETALAELEGGIY 71
Cdd:PRK05994 2 TDRSPGFATLAVHAGAQPDPTTGARATPIYQTTSFVFNDadhaaslfgLQAFGNI-YTRITNPTNAVLEERVAALEGGTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 72 ATATASGMAATALILELL--PKDSHVLVMKgVYGGTYRLFERLRKqTSGTTFSYVDLNDLASVERHIQENTGLIWIETPT 149
Cdd:PRK05994 81 ALAVASGHAAQFLVFHTLlqPGDEFIAARK-LYGGSINQFGHAFK-SFGWQVRWADADDPASFERAITPRTKAIFIESIA 158
|
170 180
....*....|....*....|.
gi 553371607 150 NPLLELVDIEAVCQVAKSRGI 170
Cdd:PRK05994 159 NPGGTVTDIAAIAEVAHRAGL 179
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
1-169 |
2.73e-23 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 94.42 E-value: 2.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPN--------LGEEGEFCYSRCSNPTRYAYETALAELEGGIYA 72
Cdd:PRK08249 3 DFNNAGVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDidewydvaLGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 73 TATASGMAATALILE--LLPKDsHVLVMKGVYGGTYRLF-ERLRKQTSGTTFsyVDLNDLASVERHIQENTGLIWIETPT 149
Cdd:PRK08249 83 TAFSTGMAAISNTLYtfLKPGD-RVVSIKDTYGGTNKIFtEFLPRMGVDVTL--CETGDHEQIEAEIAKGCDLLYLETPT 159
|
170 180
....*....|....*....|
gi 553371607 150 NPLLELVDIEAVCQVAKSRG 169
Cdd:PRK08249 160 NPTLKIVDIERLAAAAKKVG 179
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
42-170 |
4.67e-23 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 94.06 E-value: 4.67e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 42 EEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTSGTT 120
Cdd:PLN02242 64 DRDFYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAiSSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPRKCNIT 143
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 553371607 121 FSYVDLNDLASVERHIQEN-TGLIWIETPTNPLLELVDIEAVCQVAKSRGI 170
Cdd:PLN02242 144 TTFVDITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELARIAHEKGV 194
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
1-172 |
4.68e-23 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 93.99 E-value: 4.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 1 MSKSKSIATL--VIHAGDQVDRGNnAIFPPITTASSFIQPNL--------GEEGEFCYSRCSNPTRYAYETALAELEGGI 70
Cdd:PRK05968 1 MNDGLDPFDLaaLITAHDEGNAFD-AVVPPIFQTSLFTFDSYdemedvyaGEKVRPIYSRGDNPTVRAFEEMLAKLEGAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 71 YATATASGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIqENTGLIWIETPT 149
Cdd:PRK05968 80 DARGFASGMAAiSSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRM-GVEVDYVDGRDEEAVAKAL-PGAKLLYLESPT 157
|
170 180
....*....|....*....|...
gi 553371607 150 NPLLELVDIEAVCQVAKSRGIMS 172
Cdd:PRK05968 158 SWVFELQDVAALAALAKRHGVVT 180
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
6-170 |
9.68e-23 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 93.37 E-value: 9.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 6 SIATLVIHAGDQVDRGNNAIFPPITTASSFI------QPNLGEEGEF--CYSRCSNPTRYAYETALAELEGGIYATATAS 77
Cdd:PRK08248 8 RLETLAIHAGQEIDPTTGSRAVPIYQTTSYGfrdsehAANLFSLKEFgnIYTRIMNPTTDVFEKRIAALEGGIGALAVSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 78 GMAA-TALILELLPKDSHVLVMKGVYGGTYRLFER-LRKQtsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLEL 155
Cdd:PRK08248 88 GQAAiTYSILNIASAGDEIVSSSSLYGGTYNLFAHtLPKL--GITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDV 165
|
170
....*....|....*
gi 553371607 156 VDIEAVCQVAKSRGI 170
Cdd:PRK08248 166 LDIEAVAAIAHEHGI 180
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
8-170 |
2.02e-22 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 92.05 E-value: 2.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 8 ATLVIHAGDQVDRgNNAIFPPITTASSFIQP---NLGEEG-EFCYSRCSNPTRYAYETALAELEGGIYATATASGMAA-T 82
Cdd:PRK08574 4 GTDAVRGYRGSDP-YGSLQPPIYLTALFRQEgeaYPSDRGfDLKYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAiS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 83 ALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTSGTTFSYVDLNDLasVERHIQENTGLIWIETPTNPLLELVDIEAVC 162
Cdd:PRK08574 83 TLFFSLLKAGDRVVLPMEAYGTTLRLLKSLEKFGVKVVLAYPSTEDI--IEAIKEGRTKLVFIETMTNPTLKVIDVPEVA 160
|
....*...
gi 553371607 163 QVAKSRGI 170
Cdd:PRK08574 161 KAAKELGA 168
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
4-170 |
1.48e-21 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 89.78 E-value: 1.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 4 SKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNL--------GEEGEFCYSRCSNPTRYAYETALAELEGGIYATAT 75
Cdd:PRK07050 7 KRALQTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLatmraldwRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 76 ASGMAATALI-LELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLE 154
Cdd:PRK07050 87 PSGLAAISLVyFGLVKAGDDVLIPDNAYGPNRDHGEWLARDF-GITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTME 165
|
170
....*....|....*.
gi 553371607 155 LVDIEAVCQVAKSRGI 170
Cdd:PRK07050 166 VPDVPAITAAARARGV 181
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
9-171 |
3.64e-21 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 88.81 E-value: 3.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 9 TLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEG--------EFCYSRCSNPTRYAYETALAELEGGIYATATASGMA 80
Cdd:PRK06434 11 TRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAymdstrgmPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 81 A-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKqTSGTTFSYVDLNDLASVERHiQENTGLIWIETPTNPLLELVDIE 159
Cdd:PRK06434 91 AiTSAILSLIKKGKRILSISDLYGQTFYFFNKVLK-TLGIHVDYIDTDRLNSLDFD-PSNYDLIYAESITNPTLKVPDIK 168
|
170
....*....|..
gi 553371607 160 AVCQVAKSRGIM 171
Cdd:PRK06434 169 NVSSFCHENDVI 180
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
41-171 |
3.76e-21 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 88.59 E-value: 3.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 41 GEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQtsGT 119
Cdd:PRK05939 34 GKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAiAAVFLTLLRAGDHLVSSQFLFGNTNSLFGTLRGL--GV 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 553371607 120 TFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAKSRGIM 171
Cdd:PRK05939 112 EVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLL 163
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
9-170 |
2.42e-20 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 86.49 E-value: 2.42e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 9 TLVIHAGDQVDRGNNAIFPPI--TTASSFIQPNLGE-------EGEFcYSRCSNPTRYAYETALAELEGGIYATATASGM 79
Cdd:PRK06084 5 TLAIHAGYSPDPTTKAVAVPIyqTTSYAFDDTQHGAdlfdlkvPGNI-YTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 80 AATALILELLPK--DSHVLVMKgVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVD 157
Cdd:PRK06084 84 AAITYAIQTIAEagDNIVSVAK-LYGGTYNLLAHTLPRI-GIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIID 161
|
170
....*....|...
gi 553371607 158 IEAVCQVAKSRGI 170
Cdd:PRK06084 162 IQALADAAHRHGV 174
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
8-169 |
3.57e-19 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 82.74 E-value: 3.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 8 ATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEEGEFCYSRCSNPTRYAYETALAELEGGiYATATASGMAA-TALIL 86
Cdd:PRK07582 5 GTRSVHAGGPEAVPGEPVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAiTAVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 87 ELLPKDSHVLVMKGVYGGTYRLF-ERLRKQtsGTTFSYVDLNDLASverHIQENTGLIWIETPTNPLLELVDIEAVCQVA 165
Cdd:PRK07582 84 ALLRPGDTVVVPADGYYQVRALArEYLAPL--GVTVREAPTAGMAE---AALAGADLVLAETPSNPGLDVCDLAALAAAA 158
|
....
gi 553371607 166 KSRG 169
Cdd:PRK07582 159 HAAG 162
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
41-169 |
1.40e-18 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 81.70 E-value: 1.40e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 41 GEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAA--TALIlELLPKDSHVLVMKGVYGGTYRLF-ERLRKQts 117
Cdd:PRK07810 57 GELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAvfTALG-ALLGAGDRLVAARSLFGSCFVVCnEILPRW-- 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 553371607 118 GTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAKSRG 169
Cdd:PRK07810 134 GVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAG 185
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
18-169 |
5.25e-17 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 77.18 E-value: 5.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 18 VDRGNNAIFPPITTASSFIQPnlgeEGE-FCYSRCSNPTRYAYETALAELEGGIYATATASGMAA-TALILELLPKDSHV 95
Cdd:PRK06460 12 IDEATGAITTPIYQTTAYHYP----EGEkYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAiSTTALALLKPGNSV 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 553371607 96 LVMKGVYGGTYRLF-ERLRKQTSGTTFSYVdlNDLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAKSRG 169
Cdd:PRK06460 88 LVHRDMFGRSYRFFtDYLKNWGVNVDASNP--GSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENG 160
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
39-166 |
5.55e-15 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 71.62 E-value: 5.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 39 NLGEEGeFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATAL-ILELLPKDSHVLVMKGVYGGTYRLFE-RLRKQT 116
Cdd:PRK06702 47 NLEAEG-YIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLaVLNICSSGDHLLCSSTVYGGTFNLFGvSLRKLG 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 553371607 117 SGTTFSYVDLNdLASVERHIQENTGLIWIETPTNPLLELVDIEAVCQVAK 166
Cdd:PRK06702 126 IDVTFFNPNLT-ADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAK 174
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
3-169 |
1.39e-12 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 64.44 E-value: 1.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 3 KSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNL----GEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASG 78
Cdd:PRK05967 9 EKAGINTRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAetmaTRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 79 MAA-TALILELLPKDSHVLVMKGVYGGTYRLFERLRKQTsGTTFSYVDLNDLASVERHIQENTGLIWIETPTNPLLELVD 157
Cdd:PRK05967 89 LAAvTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRL-GVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQD 167
|
170
....*....|..
gi 553371607 158 IEAVCQVAKSRG 169
Cdd:PRK05967 168 IPAIAEAAHRHG 179
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
2-167 |
2.82e-12 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 63.57 E-value: 2.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 2 SKSKSIATLVIHAGDQVDRGNNAIFPPITTASSFIQPNLGEE---------GEFCYSRCSNPTRYAYETALAELEGGIYA 72
Cdd:PRK08114 1 MTDKKLDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEAKkhatrnranGELFYGRRGTLTHFSLQEAMCELEGGAGC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 73 TATASGMAATA-LILELLPKDSHVLVMKGVYGGTYRLFERLRKQTSGTTfSYVDLNDLASVERHIQENTGLIWIETPTNP 151
Cdd:PRK08114 81 ALYPCGAAAVAnAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTT-TWFDPLIGADIAKLIQPNTKVVFLESPGSI 159
|
170
....*....|....*.
gi 553371607 152 LLELVDIEAVCQVAKS 167
Cdd:PRK08114 160 TMEVHDVPAIVAAVRS 175
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
24-165 |
3.85e-10 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 57.37 E-value: 3.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 24 AIFPPITTASSFI------------------QPNLGEEGEFCYSRCSNPTRYAYETALAELEGGIYATATASGMAATALI 85
Cdd:PRK07049 35 AVKPPVFLTSTFVfrsaedgrdffdyvsgrkEPPAGEGAGLVYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIATT 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 86 LELLPKDSHVLVMKG-VYGGTYRLferLRKQTSGTTFSYVDLND---LASVERHIQENTG-----LIWIETPTNPLLELV 156
Cdd:PRK07049 115 LLAFVRPGDVILHSQpLYGGTETL---LAKTFRNFGVGAVGFADglsEAAIGAAAEAAAAkgrvsLILIETPANPTNSLV 191
|
....*....
gi 553371607 157 DIEAVCQVA 165
Cdd:PRK07049 192 DVAAVRRVA 200
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
60-170 |
2.55e-05 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 42.37 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 60 ETALAEL--EGGIYATATASGMAATALILELLPK-DSHVLVMKGVYGGTYRLFERLrkqtSGTTFSYVDLNDLASVERHI 136
Cdd:cd01494 6 EEKLARLlqPGNDKAVFVPSGTGANEAALLALLGpGDEVIVDANGHGSRYWVAAEL----AGAKPVPVPVDDAGYGGLDV 81
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 553371607 137 Q--------ENTGLIWIETPTNPLLELVDIEAVCQVAKSRGI 170
Cdd:cd01494 82 AileelkakPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGI 123
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
58-171 |
9.94e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 35.74 E-value: 9.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553371607 58 AYETALAELEGGIYATA--------TASGMAA--TALILELLPKDSHVLVMKGVYGGTYRLFErlrkqTSGTTFSYVDL- 126
Cdd:pfam00155 43 ELREALAKFLGRSPVLKldreaavvFGSGAGAniEALIFLLANPGDAILVPAPTYASYIRIAR-----LAGGEVVRYPLy 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 553371607 127 ------NDLASVERHIQENTGLIWIETPTNP---LLELVDIEAVCQVAKSRGIM 171
Cdd:pfam00155 118 dsndfhLDFDALEAALKEKPKVVLHTSPHNPtgtVATLEELEKLLDLAKEHNIL 171
|
|
| |
