|
Name |
Accession |
Description |
Interval |
E-value |
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
31-469 |
0e+00 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 585.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDLGINQANIPGQPLsytgvsgAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDGV 110
Cdd:cd16161 1 KPNFLLLFADDLGWGDLGANWAPN-------AILTPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 111 LaPDATGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLPHNRGFDIYFGIPFSCDmgcgawhgphptrcfpsplpl 190
Cdd:cd16161 74 L-PTSVGGLPLNETTLAEVLRQAGYATGMIGKWHLGQREAYLPNSRGFDYYFGIPFSHD--------------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 191 lscatgsvakveeqptnlATLTQRYADFGAAFIANHSAADRPWFLFASFNHVHVTDANYSKANPPpgysdwqfssvefcg 270
Cdd:cd16161 132 ------------------SSLADRYAQFATDFIQRASAKDRPFFLYAALAHVHVPLANLPRFQSP--------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 271 SSGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGNPEY----------GDMLGNLPLRGYKASNWEGGVRE 340
Cdd:cd16161 179 TSGRGPYGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGPWEVkcelavgpgtGDWQGNLGGSVAKASTWEGGHRE 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 341 PAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLLSGASTPHACLFHWHDSELgqGGRGLSA 420
Cdd:cd16161 259 PAIVYWPGRIPANSTSAALVSTLDIFPTVVALAGASLPPGRIYDGKDLSPVLFGGSKTGHRCLFHPNSGAA--GAGALSA 336
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 551540866 421 VRCGDYKAHFYTQNDYATEAnrSKSWPAGKQDPPLLFLLTQTEQSETVQ 469
Cdd:cd16161 337 VRCGDYKAHYATGGALACCG--STGPKLYHDPPLLFDLEVDPAESFPLT 383
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
31-457 |
5.96e-150 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 435.84 E-value: 5.96e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDLGINQanipgqpLSYTGvSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDGV 110
Cdd:cd16026 1 KPNIVVILADDLGYGD-------LGCYG-SPLIKTPNIDRLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVRVGLPGVV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 111 LAPDATGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLPHNRGFDIYFGIPFSCDMGCGAWHGPHPtrcfPSPLPL 190
Cdd:cd16026 73 GPPGSKGGLPPDEITIAEVLKKAGYRTALVGKWHLGHQPEFLPTRHGFDEYFGIPYSNDMWPFPLYRNDP----PGPLPP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 191 LscatGSVAKVEEQPTNLATLTQRYADFGAAFIANHsaADRPWFLFASFNHVHVTdanyskanpppgysdwQFSSVEFCG 270
Cdd:cd16026 149 L----MENEEVIEQPADQSSLTQRYTDEAVDFIERN--KDQPFFLYLAHTMPHVP----------------LFASEKFKG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 271 SSGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNG-NPEYGDMLG-NLPLRGYKASNWEGGVREPAIVRWPG 348
Cdd:cd16026 207 RSGAGLYGDVVEELDWSVGRILDALKELGLEENTLVIFTSDNGpWLEYGGHGGsAGPLRGGKGTTWEGGVRVPFIAWWPG 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 349 RIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLLSGASTPHACLFHWHDselgqgGRGLSAVRCGDYKA 428
Cdd:cd16026 287 VIPAGTVSDELASTMDLLPTLAALAGAPLPEDRVIDGKDISPLLLGGSKSPPHPFFYYYD------GGDLQAVRSGRWKL 360
|
410 420
....*....|....*....|....*....
gi 551540866 429 HFYTQNDYATEAnrsKSWPAGKQDPPLLF 457
Cdd:cd16026 361 HLPTTYRTGTDP---GGLDPTKLEPPLLY 386
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
32-457 |
2.73e-114 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 346.34 E-value: 2.73e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANIPGQPlsyTGVSGAIKtpnlaKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGL--GDG 109
Cdd:cd16160 2 PNIVLFFADDMGYGDLASYGHP---TQERGPID-----DMAAEGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMygGTR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 110 VLAPDATGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQ------YLPHNRGFDiYFG--IPFSCDMGCGAWH----G 177
Cdd:cd16160 74 VFLPWDIGGLPKTEVTMAEALKEAGYTTGMVGKWHLGINENnhsdgaHLPSHHGFD-FVGtnLPFTNSWACDDTGrhvdF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 178 PHPTRCFpsplplLSCATGSVakveEQPTNLATLTQRYADFGAAFIanHSAADRPWFLFASFNHVHVTdanyskanpppg 257
Cdd:cd16160 153 PDRSACF------LYYNDTIV----EQPIQHEHLTETLVGDAKSFI--EDNQENPFFLYFSFPQTHTP------------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 258 ysdwQFSSVEFCGSSGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNG-NPEYGDMLGNL-PLRGYKASNWE 335
Cdd:cd16160 209 ----LFASKRFKGKSKRGRYGDNINEMSWAVGEVLDTLVDTGLDQNTLVFFLSDHGpHVEYCLEGGSTgGLKGGKGNSWE 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 336 GGVREPAIVRWPGRIAAGVTSwALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLLSGASTPHACLFHWHDSElgqgg 415
Cdd:cd16160 285 GGIRVPFIAYWPGTIKPRVSH-EVVSTMDIFPTFVDLAGGTLPTDRIYDGLSITDLLLGEADSPHDDILYYCCSR----- 358
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 551540866 416 rgLSAVRCGDYKAHFYTQNDYATEANRSKSWPAG-----------------KQDPPLLF 457
Cdd:cd16160 359 --LMAVRYGSYKIHFKTQPLPSQESLDPNCDGGGplsdyivcydcedecvtKHNPPLIF 415
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
31-461 |
7.19e-112 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 341.35 E-value: 7.19e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDLGINQANIPGQPLSytgvsgaiKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDGV 110
Cdd:cd16158 1 PPNIVLLFADDLGYGDLGCYGHPSS--------STPNLDRLAANGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYPGV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 111 LAPDATGGLQLNETTMAETLRRLGYATAMFGKWHL--GQREQYLPHNRGFDIYFGIPFSCDMG-CgawhgpHPTRCFPSP 187
Cdd:cd16158 73 FYPGSRGGLPLNETTIAEVLKTVGYQTAMVGKWHLgvGLNGTYLPTHQGFDHYLGIPYSHDQGpC------QNLTCFPPN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 188 LPLL-SCATGSVA-------KVEEQPTNLATLTQRYADFGAAFIANHSAADRPWFLFASFNHVHVTdanyskanpppgys 259
Cdd:cd16158 147 IPCFgGCDQGEVPcplfyneSIVQQPVDLLTLEERYAKFAKDFIADNAKEGKPFFLYYASHHTHYP-------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 260 dwQFSSVEFCGSSGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGnPEYGDML--GNLPL-RGYKASNWEG 336
Cdd:cd16158 213 --QFAGQKFAGRSSRGPFGDALAELDGSVGELLQTLKENGIDNNTLVFFTSDNG-PSTMRKSrgGNAGLlKCGKGTTYEG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 337 GVREPAIVRWPGRIAAGVTSwALATTYDIYPTVMRLAGGSMpPGRVYDGKDLSAVLLSGASTPHACLFHWHDSElgQGGR 416
Cdd:cd16158 290 GVREPAIAYWPGRIKPGVTH-ELASTLDILPTIAKLAGAPL-PNVTLDGVDMSPILFEQGKSPRQTFFYYPTSP--DPDK 365
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 551540866 417 GLSAVRCGDYKAHFYTQNDYATEANRSK----SWPAGKQDPPLLFLLTQ 461
Cdd:cd16158 366 GVFAVRWGKYKAHFYTQGAAHSGTTPDKdchpSAELTSHDPPLLFDLSQ 414
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
31-501 |
7.02e-99 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 309.22 E-value: 7.02e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDLGInqanipGQPLSYTGVSgaIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGL---- 106
Cdd:cd16159 1 KPNIVLFMADDLGI------GDVGCFGNDT--IRTPNIDRLAKEGVKLTHHLAAAPLCTPSRAAFLTGRYPIRSGMassh 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 107 GDGV-LAPDATGGLQLNETTMAETLRRLGYATAMFGKWHLG------QREQYLPHNRGFDIYFGIPFSCDMGCGAWHGPH 179
Cdd:cd16159 73 GMRViLFTASSGGLPPNETTFAEVLKQQGYSTALIGKWHLGlhcesrNDFCHHPLNHGFDYFYGLPLTNLKDCGDGSNGE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 180 PTRCFPSPLPLLSCATGSVA-------------------------------------------------KVEEQPTNLAT 210
Cdd:cd16159 153 YDLSFDPLFPLLTAFVLITAltiflllylgavskrffvfllilsllfislfflllitnryfncilmrnhEVVEQPMSLEN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 211 LTQRYADFGAAFIANHSaaDRPWFLFASFNHVHVTdanyskanpppgysdwQFSSVEFCGSSGRGGTGDAVQELDDAVGQ 290
Cdd:cd16159 233 LTQRLTKEAISFLERNK--ERPFLLVMSFLHVHTA----------------LFTSKKFKGRSKHGRYGDNVEEMDWSVGQ 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 291 LLASVKRAGAERKTITFFTSDNG--------NPEYGDmlGNLPLR-GYKASNWEGGVREPAIVRWPGRIAAGvTSWALAT 361
Cdd:cd16159 295 ILDALDELGLKDNTFVYFTSDNGghleeisvGGEYGG--GNGGIYgGKKMGGWEGGIRVPTIVRWPGVIPPG-SVIDEPT 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 362 TY-DIYPTVMRLAGGSMPPGRVYDGKDLSAvLLSGAS--TPHACLFHWHDSElgqggrgLSAVRCGD------YKAHFYT 432
Cdd:cd16159 372 SLmDIFPTVAALAGAPLPSDRIIDGRDLMP-LLTGQEkrSPHEFLFHYCGAE-------LHAVRYRPrdggavWKAHYFT 443
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551540866 433 QNDYATEANRSKSWPAG-------KQDPPLLFLLTqTEQSETVQVDPASEEYASHMKVIGRARDAHLASIAPVCSQ 501
Cdd:cd16159 444 PNFYPGTEGCCGTLLCRcfgdsvtHHDPPLLFDLS-ADPSESNPLDPTDEPYQEIIKKILEAVAEHQSSIEPVESQ 518
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
32-431 |
1.02e-96 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 300.23 E-value: 1.02e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANIPGQPLsytgvsgaIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGD--- 108
Cdd:cd16144 1 PNIVLILVDDLGWADLGCYGSKF--------YETPNIDRLAKEGMRFTQAYAAAPVCSPSRASILTGQYPARLGITDvip 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 109 ---------GVLAPDATGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLPHNRGFDIYFgipfscdmgcGAWHGPH 179
Cdd:cd16144 73 grrgppdntKLIPPPSTTRLPLEEVTIAEALKDAGYATAHFGKWHLGGEGGYGPEDQGFDVNI----------GGTGNGG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 180 PTRCFPSPlpllscatGSVAKVEEQPTNLATLTQRYADFGAAFIANHsaADRPWFLFASFNHVHV-------TDANYSKA 252
Cdd:cd16144 143 PPSYYFPP--------GKPNPDLEDGPEGEYLTDRLTDEAIDFIEQN--KDKPFFLYLSHYAVHTpiqarpeLIEKYEKK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 253 NPPPGYSDWQfssVEFCGssgrggtgdAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGNPEYGDMLG--NLPLRGYK 330
Cdd:cd16144 213 KKGLRKGQKN---PVYAA---------MIESLDESVGRILDALEELGLADNTLVIFTSDNGGLSTRGGPPtsNAPLRGGK 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 331 ASNWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLLSGASTPHACLFHWH-DS 409
Cdd:cd16144 281 GSLYEGGIRVPLIVRWPGVIKPGSVSDVPVIGTDLYPTFLELAGGPLPPPQHLDGVSLVPLLKGGEADLPRRALFWHfPH 360
|
410 420
....*....|....*....|..
gi 551540866 410 ELGQGGRGLSAVRCGDYKAHFY 431
Cdd:cd16144 361 YHGQGGRPASAIRKGDWKLIEF 382
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
32-461 |
2.47e-94 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 292.13 E-value: 2.47e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGInqanipGQPLSYTG--VSGAiKTPNLAKMASEGTTFMQWYSAfHVCTPSRASLMTARLPVRLGLGDg 109
Cdd:cd16142 1 PNILVILGDDIGW------GDLGCYGGgiGRGA-PTPNIDRLAKEGLRFTSFYVE-PSCTPGRAAFITGRHPIRTGLTT- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 110 VLAPDATGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLPHNRGFDIYFGIPfscdmgcgawhgphptrcfpsplp 189
Cdd:cd16142 72 VGLPGSPGGLPPWEPTLAELLKDAGYATAQFGKWHLGDEDGRLPTDHGFDEFYGNL------------------------ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 190 llscatgsvakveeqptnLATLTQRYADFGAAFIANHSAADRPWFLFASFNHVHVTdanyskANPPPgysdwqfssvEFC 269
Cdd:cd16142 128 ------------------YHTIDEEIVDKAIDFIKRNAKADKPFFLYVNFTKMHFP------TLPSP----------EFE 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 270 GSSGRGGT-GDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGnPEY--GDMLGNLPLRGYKASNWEGGVREPAIVRW 346
Cdd:cd16142 174 GKSSGKGKyADSMVELDDHVGQILDALDELGIADNTIVIFTTDNG-PEQdvWPDGGYTPFRGEKGTTWEGGVRVPAIVRW 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 347 PGRIAAGVTSWALATTYDIYPTVMRLAGGSMPP------GRVYDGKDLSAVLL-SGASTPHACLFHWHDSELGqggrgls 419
Cdd:cd16142 253 PGKIKPGRVSNEIVSHLDWFPTLAALAGAPDPKdkllgkDRHIDGVDQSPFLLgKSEKSRRSEFFYFGEGELG------- 325
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 551540866 420 AVRCGDYKAHFYTQNDYATEANRSKSWPAGkqdpPLLFLLTQ 461
Cdd:cd16142 326 AVRWKNWKVHFKAQEDTGGPTGEPFYVLTF----PLIFNLRR 363
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
1-439 |
3.51e-90 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 282.15 E-value: 3.51e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 1 MRALLTSLLIAAqqraaafeSTTMVETPAPPPNVLLLFADDLGINQanipgqpLSYTGvSGAIKTPNLAKMASEGTTFMQ 80
Cdd:COG3119 1 MKRLLLLLLALL--------AAAAAAAAAKRPNILFILADDLGYGD-------LGCYG-NPLIKTPNIDRLAAEGVRFTN 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 81 WYSAFHVCTPSRASLMTARLPVRLGLGDgvLAPDATGGLQLNETTMAETLRRLGYATAMFGKWHLgqreqylphnrgfdi 160
Cdd:COG3119 65 AYVTSPVCSPSRASLLTGRYPHRTGVTD--NGEGYNGGLPPDEPTLAELLKEAGYRTALFGKWHL--------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 161 yfgipfscdmgcgawhgphptrcfpsplpllscatgsvakveeqptnlaTLTQRYADFGAAFIANHSAADRPWFLFASFN 240
Cdd:COG3119 128 -------------------------------------------------YLTDLLTDKAIDFLERQADKDKPFFLYLAFN 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 241 HVHV-------TDANYSKANPPPGYSDWQFSSVEFCGSSGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNG 313
Cdd:COG3119 159 APHApyqapeeYLDKYDGKDIPLPPNLAPRDLTEEELRRARAAYAAMIEEVDDQVGRLLDALEELGLADNTIVVFTSDNG 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 314 npeygDMLGNLPLRGYKASNWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGrvYDGKDLSAVLL 393
Cdd:COG3119 239 -----PSLGEHGLRGGKGTLYEGGIRVPLIVRWPGKIKAGSVSDALVSLIDLLPTLLDLAGVPIPED--LDGRSLLPLLT 311
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 551540866 394 SGASTPHACLFHWHDSELGQggrglSAVRCGDYKAHFYTQNDYATE 439
Cdd:COG3119 312 GEKAEWRDYLYWEYPRGGGN-----RAIRTGRWKLIRYYDDDGPWE 352
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
31-497 |
7.25e-90 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 283.97 E-value: 7.25e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDLGINQANIPGQPlsytgvsgAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGL---- 106
Cdd:cd16157 1 KPNIILMLMDDMGWGDLGVFGEP--------SRETPNLDRMAAEGMLFTDFYSANPLCSPSRAALLTGRLPIRNGFyttn 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 107 ---GDGVLAPDATGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLPHNRGFDIYFGIPfSCDMGcgawhgPHPTRC 183
Cdd:cd16157 73 ahaRNAYTPQNIVGGIPDSEILLPELLKKAGYRNKIVGKWHLGHRPQYHPLKHGFDEWFGAP-NCHFG------PYDNKA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 184 FPSpLPLLSCATGSVAKVEEQPTNLAT----LTQRYADFGAAFIANHSAADRPWFLFASFNHVHVtdanyskanppPGYS 259
Cdd:cd16157 146 YPN-IPVYRDWEMIGRYYEEFKIDKKTgesnLTQIYLQEALEFIEKQHDAQKPFFLYWAPDATHA-----------PVYA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 260 dwqfsSVEFCGSSGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNG-----NPEYGDmlGNLPLRGYKASNW 334
Cdd:cd16157 214 -----SKPFLGTSQRGLYGDAVMELDSSVGKILESLKSLGIENNTFVFFSSDNGaalisAPEQGG--SNGPFLCGKQTTF 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 335 EGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLLSGASTPHAcLFHWHDSELGqg 414
Cdd:cd16157 287 EGGMREPAIAWWPGHIKPGQVSHQLGSLMDLFTTSLALAGLPIPSDRAIDGIDLLPVLLNGKEKDRP-IFYYRGDELM-- 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 415 grglsAVRCGDYKAHFYTQNDYATEANRSKSWPAGKQDP-------------PLLFLLTQtEQSETVQVDPASEEYASHM 481
Cdd:cd16157 364 -----AVRLGQYKAHFWTWSNSWEEFRKGINFCPGQNVPgvtthnqtdhtklPLLFHLGR-DPGEKYPISFKSAEYKQAM 437
|
490
....*....|....*.
gi 551540866 482 KVIGRARDAHLASIAP 497
Cdd:cd16157 438 PRISKVVQQHQKTLVP 453
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
32-427 |
1.55e-80 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 257.09 E-value: 1.55e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQanipgqpLSYTGvSGAIKTPNLAKMASEGTTFMQWYSAfHVCTPSRASLMTARLPVRLGLGDGVL 111
Cdd:cd16029 1 PHIVFILADDLGWND-------VGFHG-SDQIKTPNLDALAADGVILNNYYVQ-PICTPSRAALMTGRYPIHTGMQHGVI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDATGGLQLNETTMAETLRRLGYATAMFGKWHLGQ-REQYLPHNRGFDIYFGiPFSCD------MGCGAWHGPHPTRCF 184
Cdd:cd16029 72 LAGEPYGLPLNETLLPQYLKELGYATHLVGKWHLGFyTWEYTPTNRGFDSFYG-YYGGAedyythTSGGANDYGNDDLRD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 185 psplpllscatgsvakvEEQPTNLAT---LTQRYADFGAAFIANHsAADRPWFLFASFNHVHV---TDANYSKANPPPGY 258
Cdd:cd16029 151 -----------------NEEPAWDYNgtySTDLFTDRAVDIIENH-DPSKPLFLYLAFQAVHAplqVPPEYADPYEDKFA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 259 SDWQFSSVEFCGssgrggtgdAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGNPEYGDMLG-NLPLRGYKASNWEGG 337
Cdd:cd16029 213 HIKDEDRRTYAA---------MVSALDESVGNVVDALKAKGMLDNTLIVFTSDNGGPTGGGDGGsNYPLRGGKNTLWEGG 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 338 VREPAIVRWPGRIA-AGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLLSGASTPHACLFHwHDSELGQGGR 416
Cdd:cd16029 284 VRVPAFVWSPLLPPkRGTVSDGLMHVTDWLPTLLSLAGGDPDDLPPLDGVDQWDALSGGAPSPRTEILL-NIDDITRTTG 362
|
410
....*....|.
gi 551540866 417 GlSAVRCGDYK 427
Cdd:cd16029 363 G-AAIRVGDWK 372
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
32-464 |
7.45e-79 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 252.89 E-value: 7.45e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGInqanipGQpLSYTGVSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDGVL 111
Cdd:cd16143 1 PNIVIILADDLGY------GD-ISCYNPDSKIPTPNIDRLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSRLKGGVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDATGGLQLNETTMAETLRRLGYATAMFGKWHLG-----------QREQYL-----------PHNRGFDIYFGIPfscd 169
Cdd:cd16143 74 GGFSPPLIEPDRVTLAKMLKQAGYRTAMVGKWHLGldwkkkdgkkaATGTGKdvdyskpikggPLDHGFDYYFGIP---- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 170 mgcgawhgphptrcfpsplpllscaTGSVakveeqptnLATLTQRyadfGAAFIANHSAADRPWFLFASF--NHVHVTda 247
Cdd:cd16143 150 -------------------------ASEV---------LPTLTDK----AVEFIDQHAKKDKPFFLYFALpaPHTPIV-- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 248 nyskanPPPgysdwqfssvEFCGSSGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNG---NPEYGDML--- 321
Cdd:cd16143 190 ------PSP----------EFQGKSGAGPYGDFVYELDWVVGRILDALKELGLAENTLVIFTSDNGpspYADYKELEkfg 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 322 --GNLPLRGYKASNWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLL-SGAST 398
Cdd:cd16143 254 hdPSGPLRGMKADIYEGGHRVPFIVRWPGKIPAGSVSDQLVSLTDLFATLAAIVGQKLPDNAAEDSFSFLPALLgPKKQE 333
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 551540866 399 PHACLFHwhdselgQGGRGLSAVRCGDYKAHFYTQNDYATEANRSkswPAGKQDPPLLFLLTQ--TEQ 464
Cdd:cd16143 334 VRESLVH-------HSGNGSFAIRKGDWKLIDGTGSGGFSYPRGK---EKLGLPPGQLYNLSTdpGES 391
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
32-427 |
3.05e-72 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 236.29 E-value: 3.05e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQanipgqpLSYTGvSGAIKTPNLAKMASEGTTFMQwysaFHV---CTPSRASLMTARLPVRLG--- 105
Cdd:cd16146 1 PNVILILTDDQGYGD-------LGFHG-NPILKTPNLDRLAAESVRFTN----FHVspvCAPTRAALLTGRYPFRTGvwh 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 106 --LGDGVLAPDatgglqlnETTMAETLRRLGYATAMFGKWHLGQREQYLPHNRGFDIYFGIpfscdmgCGAWHGPHPTrc 183
Cdd:cd16146 69 tiLGRERMRLD--------ETTLAEVFKDAGYRTGIFGKWHLGDNYPYRPQDRGFDEVLGH-------GGGGIGQYPD-- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 184 fpsplPLLSCATGSVAKVEEQPTNlatlTQRYAD---FGAA--FIANHSaaDRPWFLFASFNHVHvtdanyskaNP---P 255
Cdd:cd16146 132 -----YWGNDYFDDTYYHNGKFVK----TEGYCTdvfFDEAidFIEENK--DKPFFAYLATNAPH---------GPlqvP 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 256 PGYSDwQFSSVEFcgssgrgGTGDA-----VQELDDAVGQLLASVKRAGAERKTITFFTSDNGNPEYGDMLGNLPLRGYK 330
Cdd:cd16146 192 DKYLD-PYKDMGL-------DDKLAafygmIENIDDNVGRLLAKLKELGLEENTIVIFMSDNGPAGGVPKRFNAGMRGKK 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 331 ASNWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLLSG-ASTPHACLF-HWHD 408
Cdd:cd16146 264 GSVYEGGHRVPFFIRWPGKILAGKDVDTLTAHIDLLPTLLDLCGVKLPEGIKLDGRSLLPLLKGEsDPWPERTLFtHSGR 343
|
410
....*....|....*....
gi 551540866 409 SELGQGGRGLSAVRCGDYK 427
Cdd:cd16146 344 WPPPPKKKRNAAVRTGRWR 362
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
32-428 |
6.11e-72 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 235.57 E-value: 6.11e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANIPGQPLsytgvsgaIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMT----ARLPVRLGLG 107
Cdd:cd16145 1 PNIIFILADDLGYGDLGCYGQKK--------IKTPNLDRLAAEGMRFTQHYAGAPVCAPSRASLLTglhtGHTRVRGNSE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 108 DGVLAPdatggLQLNETTMAETLRRLGYATAMFGKWHLGQREQY-LPHNRGFDIYFGIpfscdMGCGAWHGPHPT----- 181
Cdd:cd16145 73 PGGQDP-----LPPDDVTLAEVLKKAGYATAAFGKWGLGGPGTPgHPTKQGFDYFYGY-----LDQVHAHNYYPEylwrn 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 182 -RCFPSPLPLLSCATGSVAKVEEQPTNLATLtqrYADFGAAFIANHsaADRPWFLFASFN----HVHVTDANYSKANPPP 256
Cdd:cd16145 143 gEKVPLPNNVIPPLDEGNNAGGGGGTYSHDL---FTDEALDFIREN--KDKPFFLYLAYTlphaPLQVPDDGPYKYKPKD 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 257 ----GYSDWQFSSVEFCGSSGRggtgdavqeLDDAVGQLLASVKRAGAERKTITFFTSDNGNPEYGDML-------GNLP 325
Cdd:cd16145 218 pgiyAYLPWPQPEKAYAAMVTR---------LDRDVGRILALLKELGIDENTLVVFTSDNGPHSEGGSEhdpdffdSNGP 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 326 LRGYKASNWEGGVREPAIVRWPGRIAAGVTS---WALattYDIYPTVMRLAGGSmPPGRVyDGKDLSAVLLS-GASTPHA 401
Cdd:cd16145 289 LRGYKRSLYEGGIRVPFIARWPGKIPAGSVSdhpSAF---WDFMPTLADLAGAE-PPEDI-DGISLLPTLLGkPQQQQHD 363
|
410 420
....*....|....*....|....*..
gi 551540866 402 CLFhWHDSELGQGgrglSAVRCGDYKA 428
Cdd:cd16145 364 YLY-WEFYEGGGA----QAVRMGGWKA 385
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
32-387 |
2.47e-68 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 220.00 E-value: 2.47e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGinqanipGQPLSYTGvSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDgvl 111
Cdd:cd16022 1 PNILLIMTDDLG-------YDDLGCYG-NPDIKTPNLDRLAAEGVRFTNAYVASPVCSPSRASLLTGRYPHRHGVRG--- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDATGGLQLNETTMAETLRRLGYATAMFGKWHlgqreqylphnrgfdiyfgipfscdmgcgawhgphptrcfpsplpll 191
Cdd:cd16022 70 NVGNGGGLPPDEPTLAELLKEAGYRTALIGKWH----------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 192 scatgsvakveeqptnlatltqryaDFGAAFIANHsAADRPWFLFASFNHVHvtdanyskanPPPGYsdwqfssvefCGs 271
Cdd:cd16022 103 -------------------------DEAIDFIERR-DKDKPFFLYVSFNAPH----------PPFAY----------YA- 135
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 272 sgrggtgdAVQELDDAVGQLLASVKRAGAERKTITFFTSDNgnpeyGDMLGNLPLRGYKASNWEGGVREPAIVRWPGRIA 351
Cdd:cd16022 136 --------MVSAIDDQIGRILDALEELGLLDNTLIVFTSDH-----GDMLGDHGLRGKKGSLYEGGIRVPFIVRWPGKIP 202
|
330 340 350
....*....|....*....|....*....|....*.
gi 551540866 352 AGVTSWALATTYDIYPTVMRLAGGSMPPGrvYDGKD 387
Cdd:cd16022 203 AGQVSDALVSLLDLLPTLLDLAGIEPPEG--LDGRS 236
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-441 |
2.25e-59 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 201.29 E-value: 2.25e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANipgqplSYTGVSgaIKTPNLAKMASEGTTFMQWYsAFHVCTPSRASLMTARLPVRLGLGDGVL 111
Cdd:cd16151 1 PNIILIMADDLGYECIG------CYGGES--YKTPNIDALAAEGVRFNNAY-AQPLCTPSRVQLMTGKYNFRNYVVFGYL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APdatgglqlNETTMAETLRRLGYATAMFGKWHLGQREQYL--PHNRGFDIYFgipfscdmgcgAWHGPH-PTRCFPSPL 188
Cdd:cd16151 72 DP--------KQKTFGHLLKDAGYATAIAGKWQLGGGRGDGdyPHEFGFDEYC-----------LWQLTEtGEKYSRPAT 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 189 PLLSCATGSVAKVEEQ---PtnlatltQRYADFGAAFIANHsaADRPWFLFASFNHVHvtdanySKANPPPGYSDWQFSS 265
Cdd:cd16151 133 PTFNIRNGKLLETTEGdygP-------DLFADFLIDFIERN--KDQPFFAYYPMVLVH------DPFVPTPDSPDWDPDD 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 266 VEFCGSSGRggTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNG-NPEYGDMLGNLPLRGYKASNWEGGVREPAIV 344
Cdd:cd16151 198 KRKKDDPEY--FPDMVAYMDKLVGKLVDKLEELGLRENTIIIFTGDNGtHRPITSRTNGREVRGGKGKTTDAGTHVPLIV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 345 RWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLSAVLLSGASTPHACLFHWHDSELGQGGRGlSAVRCG 424
Cdd:cd16151 276 NWPGLIPAGGVSDDLVDFSDFLPTLAELAGAPLPEDYPLDGRSFAPQLLGKTGSPRREWIYWYYRNPHKKFGS-RFVRTK 354
|
410 420
....*....|....*....|..
gi 551540866 425 DYK----AHFY-TQNDYATEAN 441
Cdd:cd16151 355 RYKlyadGRFFdLREDPLEKNP 376
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
32-374 |
1.03e-52 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 181.08 E-value: 1.03e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANIPGQPLSYTgvsgaiktPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDGVL 111
Cdd:pfam00884 1 PNVVLVLGESLRAPDLGLYGYPRPTT--------PFLDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVSTP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 apdatGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLPHNRGFDIYFGipfscdmgcgawhgphptrcfpspLPLL 191
Cdd:pfam00884 73 -----VGLPRTEPSLPDLLKRAGYNTGAIGKWHLGWYNNQSPCNLGFDKFFG------------------------RNTG 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 192 SCATGSVAKVEEQPTNLATLTQRYADFGAAFIANHsaaDRPWFLFASFNHVHvtDANYSKANPPPGYSDWQFSSVEFCGS 271
Cdd:pfam00884 124 SDLYADPPDVPYNCSGGGVSDEALLDEALEFLDNN---DKPFFLVLHTLGSH--GPPYYPDRYPEKYATFKPSSCSEEQL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 272 sgRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGNPEYGdmlGNLPLRGYKASN-WEGGVREPAIVRWPGRI 350
Cdd:pfam00884 199 --LNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTSDHGESLGE---GGGYLHGGKYDNaPEGGYRVPLLIWSPGGK 273
|
330 340
....*....|....*....|....
gi 551540866 351 AAGVTSWALATTYDIYPTVMRLAG 374
Cdd:pfam00884 274 AKGQKSEALVSHVDLFPTILDLAG 297
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
32-439 |
1.66e-50 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 177.70 E-value: 1.66e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQanipgqpLSYTGvsGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLgdgvl 111
Cdd:cd16027 1 PNILWIIADDLSPDL-------GGYGG--NVVKTPNLDRLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGA----- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDATGGLQLNE--TTMAETLRRLGYATAMFGKWHLGQREQYlphnrgfdiyfgiPFSCDMGCGAWHGPHPTRcfpsplp 189
Cdd:cd16027 67 HGLRSRGFPLPDgvKTLPELLREAGYYTGLIGKTHYNPDAVF-------------PFDDEMRGPDDGGRNAWD------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 190 llscatgsvakveeqptnlatltqrYADFGAAFIaNHSAADRPWFLFASFNHVH----VTDANYSKANP----PPGY--- 258
Cdd:cd16027 127 -------------------------YASNAADFL-NRAKKGQPFFLWFGFHDPHrpypPGDGEEPGYDPekvkVPPYlpd 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 259 -----SDW-QFSsvefcgssgrggtgDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGNPeygdmlgnLPlRGyKAS 332
Cdd:cd16027 181 tpevrEDLaDYY--------------DEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHGMP--------FP-RA-KGT 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 333 NWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGrvYDGKDLSAVLLSGASTPHACLF---HWHDs 409
Cdd:cd16027 237 LYDSGLRVPLIVRWPGKIKPGSVSDALVSFIDLAPTLLDLAGIEPPEY--LQGRSFLPLLKGEKDPGRDYVFaerDRHD- 313
|
410 420 430
....*....|....*....|....*....|
gi 551540866 410 ELGQGGRglsAVRCGDYKahfYTQNdYATE 439
Cdd:cd16027 314 ETYDPIR---SVRTGRYK---YIRN-YMPE 336
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-457 |
6.51e-48 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 171.21 E-value: 6.51e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLginqaniPGQPLSYTGVSgAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPvrlgLGDGVL 111
Cdd:cd16034 2 PNILFIFADQH-------RAQALGCAGDD-PVKTPNLDRLAKEGVVFTNAVSNYPVCSPYRASLLTGQYP----LTNGVF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDATggLQLNETTMAETLRRLGYATAMFGKWHL--------GQREQYLPHNR--GFDIYFGipfscdMGCGAWHG-PH- 179
Cdd:cd16034 70 GNDVP--LPPDAPTIADVLKDAGYRTGYIGKWHLdgperndgRADDYTPPPERrhGFDYWKG------YECNHDHNnPHy 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 180 ----PTRCFP---SPLPLlscatgsvakveeqpTNLAtltqryadfgAAFIANHSAADRPWFLFASFNHVHvtdANYSKA 252
Cdd:cd16034 142 ydddGKRIYIkgySPDAE---------------TDLA----------IEYLENQADKDKPFALVLSWNPPH---DPYTTA 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 253 nPPPGYSDWQFSSVEF-----CGSSGRGGTGDAVQE-------LDDAVGQLLASVKRAGAERKTITFFTSDngnpeYGDM 320
Cdd:cd16034 194 -PEEYLDMYDPKKLLLrpnvpEDKKEEAGLREDLRGyyamitaLDDNIGRLLDALKELGLLENTIVVFTSD-----HGDM 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 321 LGNLPLRGyKASNWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGrvYDGKDLSAVLLSGASTPH 400
Cdd:cd16034 268 LGSHGLMN-KQVPYEESIRVPFIIRYPGKIKAGRVVDLLINTVDIMPTLLGLCGLPIPDT--VEGRDLSPLLLGGKDDEP 344
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551540866 401 A-----CL--FHWHDSELGQGGRGlsaVRCGDYKahfytqndYATEANrskswpagkqDPPLLF 457
Cdd:cd16034 345 DsvllqCFvpFGGGSARDGGEWRG---VRTDRYT--------YVRDKN----------GPWLLF 387
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
31-428 |
8.95e-48 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 171.09 E-value: 8.95e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDLGinqaniPGQPLSYtGvsGAIKTPNLAKMASEGTTfmqwYSAFHV---CTPSRASLMTARLPVRLGLG 107
Cdd:cd16025 2 RPNILLILADDLG------FSDLGCF-G--GEIPTPNLDALAAEGLR----FTNFHTtalCSPTRAALLTGRNHHQVGMG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 108 dgVLAPDATG----GLQLNE--TTMAETLRRLGYATAMFGKWHLGQREQYlphnrgfdiyfgipfscdmgcgawhgphpt 181
Cdd:cd16025 69 --TMAELATGkpgyEGYLPDsaATIAEVLKDAGYHTYMSGKWHLGPDDYY------------------------------ 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 182 rcfpsplpllscatgsvakveeqptnlatLTQRYADFGAAFIANHSAADRPWFLFASFNHVH------------------ 243
Cdd:cd16025 117 -----------------------------STDDLTDKAIEYIDEQKAPDKPFFLYLAFGAPHaplqapkewidkykgkyd 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 244 ------------------VTDANYSKANPPPGYSDW-QFSSVE----------FCGssgrggtgdAVQELDDAVGQLLAS 294
Cdd:cd16025 168 agwdalreerlerqkelgLIPADTKLTPRPPGVPAWdSLSPEEkklearrmevYAA---------MVEHMDQQIGRLIDY 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 295 VKRAGAERKTITFFTSDNG-NPEYG-DMLGNLPLRGYKASNWEGGVREPAIVRWPGRIAA-GVTSWALATTYDIYPTVMR 371
Cdd:cd16025 239 LKELGELDNTLIIFLSDNGaSAEPGwANASNTPFRLYKQASHEGGIRTPLIVSWPKGIKAkGGIRHQFAHVIDIAPTILE 318
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551540866 372 LAGGSmPPGRVY-------DGKDLsAVLLSGASTPHaclfhwHDSELG---QGGRglsAVRCGDYKA 428
Cdd:cd16025 319 LAGVE-YPKTVNgvpqlplDGVSL-LPTLDGAAAPS------RRRTQYfelFGNR---AIRKGGWKA 374
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
31-436 |
1.60e-43 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 160.00 E-value: 1.60e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDlginQANipgQPLSYTGvSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDGv 110
Cdd:cd16031 2 RPNIIFILTDD----HRY---DALGCYG-NPIVKTPNIDRLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGVTDN- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 111 lapdATGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLPhnRGFDIYFGIPfscdmgcgAWHGPHPTRcFPSPlpl 190
Cdd:cd16031 73 ----NGPLFDASQPTYPKLLRKAGYQTAFIGKWHLGSGGDLPP--PGFDYWVSFP--------GQGSYYDPE-FIEN--- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 191 lscatGSVAKVEEQPTNLatltqrYADFGAAFIaNHSAADRPWFLFASFNHVHVTD-------ANYSKAN-PPP------ 256
Cdd:cd16031 135 -----GKRVGQKGYVTDI------ITDKALDFL-KERDKDKPFCLSLSFKAPHRPFtpaprhrGLYEDVTiPEPetfddd 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 257 -----------------GYSDWQFSSVE--------FCGssgrggtgdAVQELDDAVGQLLASVKRAGAERKTITFFTSD 311
Cdd:cd16031 203 dyagrpewareqrnrirGVLDGRFDTPEkyqrymkdYLR---------TVTGVDDNVGRILDYLEEQGLADNTIIIYTSD 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 312 NGNpeygdMLGNlplRGY--KASNWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGrvYDGKDLs 389
Cdd:cd16031 274 NGF-----FLGE---HGLfdKRLMYEESIRVPLIIRDPRLIKAGTVVDALVLNIDFAPTILDLAGVPIPED--MQGRSL- 342
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 551540866 390 AVLLSG---ASTPHACLFHWHDSELGQGGRGLSAVRCGDYK-AHFYTQNDY 436
Cdd:cd16031 343 LPLLEGekpVDWRKEFYYEYYEEPNFHNVPTHEGVRTERYKyIYYYGVWDE 393
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
32-459 |
1.90e-36 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 138.10 E-value: 1.90e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGinqanipGQPLSYTGvSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGlgdgvl 111
Cdd:cd16032 1 PNILLIMADQLT-------AAALPAYG-NTVVKTPNLDRLAARGVVFDNAYCNSPLCAPSRASMMTGRLPSRIG------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDATGGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYlpHnrGFDiyfgipFSCDMgcgawhgphptrcfpsplpll 191
Cdd:cd16032 67 AYDNAAEFPADIPTFAHYLRAAGYRTALSGKMHFVGPDQL--H--GFD------YDEEV--------------------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 192 scatgsVAKVEEQPTNLAtltqRYADfgaafianhsaaDRPWFLFASFNHVHvtdanySKANPPPGYSDWqfssveFCGS 271
Cdd:cd16032 116 ------AFKAVQKLYDLA----RGED------------GRPFFLTVSFTHPH------DPYVIPQEYWDL------YVRR 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 272 SGRGGTGdAVQELDDAVGQLLASVKRAGAERKTITFFTSDngnpeYGDMLGNlplRG--YKASNWEGGVREPAIVRWPGR 349
Cdd:cd16032 162 ARRAYYG-MVSYVDDKVGQLLDTLERTGLADDTIVIFTSD-----HGDMLGE---RGlwYKMSFFEGSARVPLIISAPGR 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 350 IAAGVTSwALATTYDIYPTVMRLAGGSMPPGRV-YDGKDLSAVLLSGASTPHACLFhwhdSE-LGQGGRG-LSAVRCGDY 426
Cdd:cd16032 233 FAPRRVA-EPVSLVDLLPTLVDLAGGGTAPHVPpLDGRSLLPLLEGGDSGGEDEVI----SEyLAEGAVApCVMIRRGRW 307
|
410 420 430
....*....|....*....|....*....|...
gi 551540866 427 KaHFYTQNdyateanrskswpagkqDPPLLFLL 459
Cdd:cd16032 308 K-FIYCPG-----------------DPDQLFDL 322
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-436 |
4.59e-36 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 138.89 E-value: 4.59e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADdlginQANipGQPLSYTGvSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDGVL 111
Cdd:cd16033 1 PNILFIMTD-----QQR--YDTLGCYG-NPIVKTPNIDRLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDAT-GGLQLNETTMAETLRRLGYATAMFGKWHLGQREqyLPHNRGFDiyfgipfscdmgcgAWHGPHPTRcfpsplpl 190
Cdd:cd16033 73 NAGAYsRGLPPGVETFSEDLREAGYRNGYVGKWHVGPEE--TPLDYGFD--------------EYLPVETTI-------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 191 lscatgsvakveeqptnlatlTQRYADFGAAFIANHSAADRPWFLFASFNHVH----VTDANYSKANP-----PPGYSD- 260
Cdd:cd16033 129 ---------------------EYFLADRAIEMLEELAADDKPFFLRVNFWGPHdpyiPPEPYLDMYDPediplPESFADd 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 261 --------------WQFSSVefcgssgrggTGDAVQE-----------LDDAVGQLLASVKRAGAERKTITFFTSDngnp 315
Cdd:cd16033 188 fedkpyiyrrerkrWGVDTE----------DEEDWKEiiahywgyitlIDDAIGRILDALEELGLADDTLVIFTSD---- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 316 eYGDMLGNLPLRGYKASNWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGgsMPPGRVYDGKDLSAVLLSG 395
Cdd:cd16033 254 -HGDALGAHRLWDKGPFMYEETYRIPLIIKWPGVIAAGQVVDEFVSLLDLAPTILDLAG--VDVPPKVDGRSLLPLLRGE 330
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 551540866 396 ASTP----HACLFHWHDSELGQggrglSAVRCGDYKahfYTQNDY 436
Cdd:cd16033 331 QPEDwrdeVVTEYNGHEFYLPQ-----RMVRTDRYK---YVFNGF 367
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-432 |
1.42e-34 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 133.84 E-value: 1.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANIPGQPlsytgvsgAIKTPNLAKMASEGTTFMQWY--SAFH--VCTPSRASLMTARLPVRLGLG 107
Cdd:cd16155 3 PNILFILADDQRADTIGALGNP--------EIQTPNLDRLARRGTSFTNAYnmGGWSgaVCVPSRAMLMTGRTLFHAPEG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 108 DGVLAPdatgglqLNETTMAETLRRLGYATAMFGKWHLGqreqylphnrgfdiyfgipfscdmgcgawhgphptrcfpsp 187
Cdd:cd16155 75 GKAAIP-------SDDKTWPETFKKAGYRTFATGKWHNG----------------------------------------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 188 lpllscatgsvakveeqptnlatltqrYADFGAAFIANHSAADRPWFLFASFNHVHVT-------DANYS------KANP 254
Cdd:cd16155 107 ---------------------------FADAAIEFLEEYKDGDKPFFMYVAFTAPHDPrqappeyLDMYPpetiplPENF 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 255 PPGYsdwQFSSVEFCGSSGRG----GTGDAVQE-----------LDDAVGQLLASVKRAGAERKTITFFTSDNGnpeygd 319
Cdd:cd16155 160 LPQH---PFDNGEGTVRDEQLapfpRTPEAVRQhlaeyyamithLDAQIGRILDALEASGELDNTIIVFTSDHG------ 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 320 M-LGNLPLRGyKASNWEGGVREPAIVRWPGrIAAGVTSWALATTYDIYPTVMRLAGGSMPPGrvYDGKDLSAVLLSGAST 398
Cdd:cd16155 231 LaVGSHGLMG-KQNLYEHSMRVPLIISGPG-IPKGKRRDALVYLQDVFPTLCELAGIEIPES--VEGKSLLPVIRGEKKA 306
|
410 420 430
....*....|....*....|....*....|....*
gi 551540866 399 PHACLFHWHdselgqggRGLS-AVRCGDYKAHFYT 432
Cdd:cd16155 307 VRDTLYGAY--------RDGQrAIRDDRWKLIIYV 333
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-431 |
1.43e-33 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 129.97 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADdlginQANIpgqplSYTGVSG--AIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGD- 108
Cdd:cd16037 1 PNILIIMSD-----EHNP-----DAMGCYGhpVVRTPNLDRLAARGTRFENAYTPSPICVPSRASFLTGRYVHETGVWDn 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 109 -GVLAPDATgglqlnetTMAETLRRLGYATAMFGKWHLGQREQYLphnrGFDiyfgipfscdmgcgawhgphptrcfpsp 187
Cdd:cd16037 71 aDPYDGDVP--------SWGHALRAAGYETVLIGKLHFRGEDQRH----GFR---------------------------- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 188 lpllscatgsvakVEEQPTNLAtltqryadfgAAFIANHSAADRPWFLFASFNHVH----VTDANYSKanpppgYsdwqf 263
Cdd:cd16037 111 -------------YDRDVTEAA----------VDWLREEAADDKPWFLFVGFVAPHfpliAPQEFYDL------Y----- 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 264 ssVEFCgssgRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDngnpeYGDMLGNlplRG--YKASNWEGGVREP 341
Cdd:cd16037 157 --VRRA----RAAYYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSD-----HGDMLGE---RGlwGKSTMYEESVRVP 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 342 AIVRWPGrIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRvyDGKDLSAVLLSGASTPHA--CLFHWHDSElgQGGRgls 419
Cdd:cd16037 223 MIISGPG-IPAGKRVKTPVSLVDLAPTILEAAGAPPPPDL--DGRSLLPLAEGPDDPDRVvfSEYHAHGSP--SGAF--- 294
|
410
....*....|..
gi 551540866 420 AVRCGDYKAHFY 431
Cdd:cd16037 295 MLRKGRWKYIYY 306
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-389 |
3.58e-33 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 126.97 E-value: 3.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGinqanipgqP--LSYTGVSGAIkTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGDG 109
Cdd:cd16149 1 PNILFILTDDQG---------PwaLGCYGNSEAV-TPNLDRLAAEGVRFENFFCTSPVCSPARASLLTGRMPSQHGIHDW 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 110 V------LAPDATGGLQlNETTMAETLRRLGYATAMFGKWHLGqreqylphnrgfdiyfgipfscdmgcgawhgphptrc 183
Cdd:cd16149 71 IvegshgKTKKPEGYLE-GQTTLPEVLQDAGYRCGLSGKWHLG------------------------------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 184 fpsplpllscatgsvakveeqptnlatltqryaDFGAAFIANHSAADRPWFLFASFNHVHvtdanyskanpppgySDWQF 263
Cdd:cd16149 113 ---------------------------------DDAADFLRRRAEAEKPFFLSVNYTAPH---------------SPWGY 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 264 SSvefcgssgrggtgdAVQELDDAVGQLLASVKRAGAERKTITFFTSDNG-----NPEYGDmlGNlplrGYKASN-WEGG 337
Cdd:cd16149 145 FA--------------AVTGVDRNVGRLLDELEELGLTENTLVIFTSDNGfnmghHGIWGK--GN----GTFPLNmYDNS 204
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 551540866 338 VREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYDGKDLS 389
Cdd:cd16149 205 VKVPFIIRWPGVVPAGRVVDSLVSAYDFFPTLLELAGVDPPADPRLPGRSFA 256
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-437 |
9.27e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 125.93 E-value: 9.27e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANipgqplSYTGVSGAIKTPNLAKMASEGTTFMQWYsAFHVCTPSRASLMTARLPVRlglgDGVL 111
Cdd:cd16154 1 PNILLIIADDQGLDSSA------QYSLSSDLPVTPTLDSLANSGIVFDNLW-ATPACSPTRATILTGKYGFR----TGVL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDatGGLQLNETTMAETL----RRLGYATAMFGKWHLGQREQYLPHNRGFDIYFGIpfscdmgcgawhgphptrcFPSP 187
Cdd:cd16154 70 AVP--DELLLSEETLLQLLikdaTTAGYSSAVIGKWHLGGNDNSPNNPGGIPYYAGI-------------------LGGG 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 188 LPLLSCATGSVAKVEEQPTNLAT--LTqryaDFGAAFIANHSaadRPWFLFASFN--HV--HVTDANYSKANPPPGYSDW 261
Cdd:cd16154 129 VQDYYNWNLTNNGQTTNSTEYATtkLT----NLAIDWIDQQT---KPWFLWLAYNapHTpfHLPPAELHSRSLLGDSADI 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 262 QFSSVEFCGSsgrggtgdAVQELDDAVGQLLASVKRAGAERkTITFFTSDNGNPeyGDMLgNLP--LRGYKASNWEGGVR 339
Cdd:cd16154 202 EANPRPYYLA--------AIEAMDTEIGRLLASIDEEEREN-TIIIFIGDNGTP--GQVV-DLPytRNHAKGSLYEGGIN 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 340 EPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPpgRVYDGKDLSAVLLSGASTPHACLFhwhdSELGQGGRGLS 419
Cdd:cd16154 270 VPLIVSGAGVERANERESALVNATDLYATIAELAGVDAA--EIHDSVSFKPLLSDVNASTRQYNY----TEYESPTTTGW 343
|
410
....*....|....*...
gi 551540866 420 AVRCGDYKAHFYTQNDYA 437
Cdd:cd16154 344 ATRNQYYKLIESENGQEE 361
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
32-398 |
3.00e-30 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 123.63 E-value: 3.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADD-----LGINqanipGQPlsytgvsgAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPV---R 103
Cdd:PRK13759 7 PNIILIMVDQmrgdcLGCN-----GNK--------AVETPNLDMLASEGYNFENAYSAVPSCTPARAALLTGLSQWhhgR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 104 LGLGDGVlapdatggLQLNETTMAETLRRLGYATAMFGKWHL-GQR-----------EQYLPHNR--------------- 156
Cdd:PRK13759 74 VGYGDVV--------PWNYKNTLPQEFRDAGYYTQCIGKMHVfPQRnllgfhnvllhDGYLHSGRnedksqfdfvsdyla 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 157 -------GFDI-YFGIPFSC-DMGCGAWHGP---HPTRCfpsplpllscaTGSVAkveeqptnlATLTQRYADfgaafia 224
Cdd:PRK13759 146 wlrekapGKDPdLTDIGWDCnSWVARPWDLEerlHPTNW-----------VGSES---------IEFLRRRDP------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 225 nhsaaDRPWFLFASFNHVHvtdanySKANPP--------------PGYSDWQFSSVEFCGS----SGRGGTGDAVQE--- 283
Cdd:PRK13759 199 -----TKPFFLKMSFARPH------SPYDPPkryfdmykdadipdPHIGDWEYAEDQDPEGgsidALRGNLGEEYARrar 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 284 ---------LDDAVGQLLASVKRAGAERKTITFFTSDngnpeYGDMLG--NLPLRGYKasnWEGGVREPAIVRWPG---R 349
Cdd:PRK13759 268 aayyglithIDHQIGRFLQALKEFGLLDNTIILFVSD-----HGDMLGdhYLFRKGYP---YEGSAHIPFIIYDPGgllA 339
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 551540866 350 IAAGVTSWALATTYDIYPTVMRLAGGSMPpgRVYDGKDLSAvLLSGAST 398
Cdd:PRK13759 340 GNRGTVIDQVVELRDIMPTLLDLAGGTIP--DDVDGRSLKN-LIFGQYE 385
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
31-407 |
3.65e-30 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 122.68 E-value: 3.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDLginqaNipgqplSYTGVSGA--IKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGD 108
Cdd:cd16030 2 KPNVLFIAVDDL-----R------PWLGCYGGhpAKTPNIDRLAARGVLFTNAYCQQPVCGPSRASLLTGRRPDTTGVYD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 109 G-----VLAPDAtgglqlneTTMAETLRRLGYATAMFGK-WHlGQREQYLPHNRGFDIYFGIPfscdmgcGAWHGPHPTR 182
Cdd:cd16030 71 NnsyfrKVAPDA--------VTLPQYFKENGYTTAGVGKiFH-PGIPDGDDDPASWDEPPNPP-------GPEKYPPGKL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 183 CFPSPLPL---LSCATGSVAKVEEQPTNLATltqryADFGAAFIANHSAADRPWFLFASFN--HV--------------- 242
Cdd:cd16030 135 CPGKKGGKgggGGPAWEAADVPDEAYPDGKV-----ADEAIEQLRKLKDSDKPFFLAVGFYkpHLpfvapkkyfdlyple 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 243 --HVTDANYSKANPPPGYSDW----QFSSVEFCGSSGRGGTGD-------------AVQELDDAVGQLLASVKRAGAERK 303
Cdd:cd16030 210 siPLPNPFDPIDLPEVAWNDLddlpKYGDIPALNPGDPKGPLPdeqarelrqayyaSVSYVDAQVGRVLDALEELGLADN 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 304 TITFFTSDNG--NPEYGdMLGnlplrgyKASNWEGGVREPAIVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGR 381
Cdd:cd16030 290 TIVVLWSDHGwhLGEHG-HWG-------KHTLFEEATRVPLIIRAPGVTKPGKVTDALVELVDIYPTLAELAGLPAPPCL 361
|
410 420
....*....|....*....|....*.
gi 551540866 382 vyDGKDLSAVLLSGASTPHACLFHWH 407
Cdd:cd16030 362 --EGKSLVPLLKNPSAKWKDAAFSQY 385
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-388 |
5.78e-30 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 118.42 E-value: 5.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLF-----ADDLGInqanipgqplsytGVSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGL 106
Cdd:cd16148 1 MNVILIVidslrADHLGC-------------YGYDRVTTPNLDRLAAEGVVFDNHYSGSNPTLPSRFSLFTGLYPFYHGV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 107 GDGVLAPDatgglqlnETTMAETLRRLGYATAMFGKW-HLGQREQYlphNRGFDIYFgipfscdmgcgaWHGPHPTRCfp 185
Cdd:cd16148 68 WGGPLEPD--------DPTLAEILRKAGYYTAAVSSNpHLFGGPGF---DRGFDTFE------------DFRGQEGDP-- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 186 splpllscatgsvakVEEQPTNLATLTQRyadfGAAFIANHsAADRPWFLFASFNHVHvtdANYskanpppGYSdwqfSS 265
Cdd:cd16148 123 ---------------GEEGDERAERVTDR----ALEWLDRN-ADDDPFFLFLHYFDPH---EPY-------LYD----AE 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 266 VEFCgssgrggtgdavqelDDAVGQLLASVKRAGAERKTITFFTSDNGNpEYGDmLGNLPLRGYKASNWEggVREPAIVR 345
Cdd:cd16148 169 VRYV---------------DEQIGRLLDKLKELGLLEDTLVIVTSDHGE-EFGE-HGLYWGHGSNLYDEQ--LHVPLIIR 229
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 551540866 346 WPGRIAAGVTSwALATTYDIYPTVMRLAGGSMPPGrvYDGKDL 388
Cdd:cd16148 230 WPGKEPGKRVD-ALVSHIDIAPTLLDLLGVEPPDY--SDGRSL 269
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
31-386 |
5.27e-27 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 113.03 E-value: 5.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADDlginqanipgQPLSYTGVSGAIKTPNLakMASEGTTFMQWYSAFHVCTPSRASLMTARLP----VRlgl 106
Cdd:cd16147 1 RPNIVLILTDD----------QDVELGSMDPMPKTKKL--LADQGTTFTNAFVTTPLCCPSRASILTGQYAhnhgVT--- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 107 gdGVLAPDatGG------LQLNETTMAETLRRLGYATAMFGK----WHLGQREQYLPhnRGFDIYFGipfscdMGCGAWH 176
Cdd:cd16147 66 --NNSPPG--GGypkfwqNGLERSTLPVWLQEAGYRTAYAGKylngYGVPGGVSYVP--PGWDEWDG------LVGNSTY 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 177 GPHptrcfpsplpllscaTGSVAKVEEQPTNLAT--LTQRYADFGAAFIANHSAADRPWFLFASFN--HVHVTDA----- 247
Cdd:cd16147 134 YNY---------------TLSNGGNGKHGVSYPGdyLTDVIANKALDFLRRAAADDKPFFLVVAPPapHGPFTPApryan 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 248 ---NYSKANPPPGYSDWQFSSVEFCGSSGRGGTGD-------------AVQELDDAVGQLLASVKRAGAERKTITFFTSD 311
Cdd:cd16147 199 lfpNVTAPPRPPPNNPDVSDKPHWLRRLPPLNPTQiayidelyrkrlrTLQSVDDLVERLVNTLEATGQLDNTYIIYTSD 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 551540866 312 NGnpeYgdMLGNLPLRGYKASNWEGGVREPAIVRWPGrIAAGVTSWALATTYDIYPTVMRLAGGsmPPGRVYDGK 386
Cdd:cd16147 279 NG---Y--HLGQHRLPPGKRTPYEEDIRVPLLVRGPG-IPAGVTVDQLVSNIDLAPTILDLAGA--PPPSDMDGR 345
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
31-392 |
1.05e-26 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 111.55 E-value: 1.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 31 PPNVLLLFADD-----LGINqanipGQPLSYTgvsgaiktPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLG 105
Cdd:cd16152 1 KPNVIVFFTDQqrwdtLGCY-----GQPLDLT--------PNLDALAEEGVLFENAFTPQPVCGPARACLQTGLYPTETG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 106 L--GDGVLAPDatgglqlnETTMAETLRRLGYATAMFGKWHL-GQREQYLphnrgfdiyfgipfscdmgcgawhgphptr 182
Cdd:cd16152 68 CfrNGIPLPAD--------EKTLAHYFRDAGYETGYVGKWHLaGYRVDAL------------------------------ 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 183 cfpsplpllscatgsvakveeqptnlatltqryADFGAAFIANHSaADRPWFLFASFNHVHvtDANYSKANPPPGYSDWQ 262
Cdd:cd16152 110 ---------------------------------TDFAIDYLDNRQ-KDKPFFLFLSYLEPH--HQNDRDRYVAPEGSAER 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 263 FSSVEFCGS-SGRGGT-----GD---AVQELDDAVGQLLASVKRAGAERKTITFFTSDNG------NPEygdmlgnlplr 327
Cdd:cd16152 154 FANFWVPPDlAALPGDwaeelPDylgCCERLDENVGRIRDALKELGLYDNTIIVFTSDHGchfrtrNAE----------- 222
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 551540866 328 gYKASNWEGGVREPAIVRWPGrIAAGVTSWALATTYDIYPTVMRLAGGSMPPGrvYDGKDLSAVL 392
Cdd:cd16152 223 -YKRSCHESSIRVPLVIYGPG-FNGGGRVEELVSLIDLPPTLLDAAGIDVPEE--MQGRSLLPLV 283
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
32-373 |
4.53e-24 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 100.96 E-value: 4.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGInqANIPGqplsytGVSGAIKTPNLAKMASEGTTF-MQWYSAFHVCTPSRASLMTARLPVRLGLG--- 107
Cdd:cd00016 1 KHVVLIVLDGLGA--DDLGK------AGNPAPTTPNLKRLASEGATFnFRSVSPPTSSAPNHAALLTGAYPTLHGYTgng 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 108 -DGVLAPDATGGLQLNETTMAETLRRLGYATAMFGKWhlgqreqylphnrgfdiyfgipfscdmgcgawhgphptrcfps 186
Cdd:cd00016 73 sADPELPSRAAGKDEDGPTIPELLKQAGYRTGVIGLL------------------------------------------- 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 187 plpllscatgsvAKVEEQptnlatltqryadfgaafianhsAADRPWFLFASFNHVHVTDanYSKANPPPGYsdwqfssv 266
Cdd:cd00016 110 ------------KAIDET-----------------------SKEKPFVLFLHFDGPDGPG--HAYGPNTPEY-------- 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 267 efcgssgrggtGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGNPEYGdmLGNLPLRGYKASNWEGGVREPAIVRW 346
Cdd:cd00016 145 -----------YDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHGGIDKG--HGGDPKADGKADKSHTGMRVPFIAYG 211
|
330 340
....*....|....*....|....*..
gi 551540866 347 PGRIAAGVTSwALATTYDIYPTVMRLA 373
Cdd:cd00016 212 PGVKKGGVKH-ELISQYDIAPTLADLL 237
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
32-430 |
2.36e-23 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 102.72 E-value: 2.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLginqaniPGQPLSYTGvSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLP-----VRLGl 106
Cdd:cd16028 1 RNVLFITADQW-------RADCLSCLG-HPLVKTPNLDRLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLmnhrsVWNG- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 107 gdgvlAPdatggLQLNETTMAETLRRLGYATAMFGKWHlgqreqYLPHNRGFDiyfgipfscdmgcgawhgphptRCFPS 186
Cdd:cd16028 72 -----TP-----LDARHLTLALELRKAGYDPALFGYTD------TSPDPRGLA----------------------PLDPR 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 187 PLPLLSCATG--SVAKVEEQPTNL---ATLTQRYADfgaaFIANHSaaDRPWFLFASFNHVH---VTDANYSK------- 251
Cdd:cd16028 114 LLSYELAMPGfdPVDRLDEYPAEDsdtAFLTDRAIE----YLDERQ--DEPWFLHLSYIRPHppfVAPAPYHAlydpadv 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 252 ------------ANPPPGYSDWQ-------FSSVEFCGSSGRGGTGDAVQ--------ELDDAVGQLLASVKRAGAERKT 304
Cdd:cd16028 188 pppiraeslaaeAAQHPLLAAFLerieslsFSPGAANAADLDDEEVAQMRatylgliaEVDDHLGRLFDYLKETGQWDDT 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 305 ITFFTSDngnpeYGDMLGNLPLRGyKASNWEGGVREPAIVRWPGRiAAGVTSW----ALATTYDIYPTVMRLAGGSMPPg 380
Cdd:cd16028 268 LIVFTSD-----HGEQLGDHWLWG-KDGFFDQAYRVPLIVRDPRR-EADATRGqvvdAFTESVDVMPTILDWLGGEIPH- 339
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 551540866 381 rVYDGKDLSAvLLSGA--STPHACLFHWHDSELGQGGR-----GLS-------AVRCGDYK-AHF 430
Cdd:cd16028 340 -QCDGRSLLP-LLAGAqpSDWRDAVHYEYDFRDVSTRRpqealGLSpdecslaVIRDERWKyVHF 402
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-406 |
1.91e-22 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 98.05 E-value: 1.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADdlginqanipgQ---PLSYTGVSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRLGLGD 108
Cdd:cd16035 1 PNILLILTD-----------QeryPPPWPAGWAALNLPARERLAANGLSFENHYTAACMCSPSRSTLYTGLHPQQTGVTD 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 109 gvlAPDATGGLQLNET--TMAETLRRLGYATAMFGKWHLGQreqylphnrgfdiyfgipfscdmgcGAWHGPHptrcfps 186
Cdd:cd16035 70 ---TLGSPMQPLLSPDvpTLGHMLRAAGYYTAYKGKWHLSG-------------------------AAGGGYK------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 187 plpllscatgsvakveeqptnlatLTQRYADFGAAFIANH---SAADRPWFLFASFNHVHvtDANYskanPPPGYSDWQF 263
Cdd:cd16035 115 ------------------------RDPGIAAQAVEWLRERgakNADGKPWFLVVSLVNPH--DIMF----PPDDEERWRR 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 264 ssvefcgssGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDngnpeYGDMLGNLPLRGyKASN-WEGGVREPA 342
Cdd:cd16035 165 ---------FRNFYYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSD-----HGEMGGAHGLRG-KGFNaYEEALHVPL 229
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 343 IVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPGRVYD----GKDLSAVLLSGASTP--HACLFHW 406
Cdd:cd16035 230 IISHPDLFGTGQTTDALTSHIDLLPTLLGLAGVDAEARATEApplpGRDLSPLLTDADADAvrDGILFTY 299
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-388 |
3.66e-22 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 96.68 E-value: 3.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANIPGQPLSYTGVS--GAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVRlglgDG 109
Cdd:cd16153 2 PNILWIITDDQRVDSLSCYNNAHTGKSESrlGYVESPNIDALAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHR----TG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 110 VLAPDAT-GGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLphnrgfdiyfgipfscdmgcgawhgphptrcfpspl 188
Cdd:cd16153 78 VYGFEAAhPALDHGLPTFPEVLKKAGYQTASFGKSHLEAFQRYL------------------------------------ 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 189 pllscatgsvakveEQPTNLATLTQRYADFGAafianhsAADRPWFLFASFNHVHvtdanySKANPPPGYSDwQFSSVEF 268
Cdd:cd16153 122 --------------KNANQSYKSFWGKIAKGA-------DSDKPFFVRLSFLQPH------TPVLPPKEFRD-RFDYYAF 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 269 CGSsgrggtgdavqeLDDAVGQLLASVKRAGAERK---TITFFTSDngnpeYGDMLGNLPLRGyKASNWEGGVREPAIVR 345
Cdd:cd16153 174 CAY------------GDAQVGRAVEAFKAYSLKQDrdyTIVYVTGD-----HGWHLGEQGILA-KFTFWPQSHRVPLIVV 235
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 551540866 346 WPGRIAAGVTSWA--LATTYDIYPTVMRLAGGSMPPGRVYDGKDL 388
Cdd:cd16153 236 SSDKLKAPAGKVRhdFVEFVDLAPTLLAAAGVDVDAPDYLDGRDL 280
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
32-433 |
2.24e-21 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 96.53 E-value: 2.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGINQANIPGQPlsytgvsgAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLP-VRlglG--- 107
Cdd:cd16150 1 PNIVIFVADQLRADSLGHLGNP--------AAVTPNLDALAAEGVRFSNAYCQNPVCSPSRCSFLTGWYPhVN---Ghrt 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 108 -DGVLAPDatgglqlnETTMAETLRRLGYATAMFGKWHlgqreqylphnrgfdiyfgipfscdmgcgawhgphptrCFPS 186
Cdd:cd16150 70 lHHLLRPD--------EPNLLKTLKDAGYHVAWAGKND--------------------------------------DLPG 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 187 PlpllsCATGSVAKVEEqptnlatLTQRYAdfgAAFIANHSaADRPWFLFASFNHVH----VTDANYS----KANPP--P 256
Cdd:cd16150 104 E-----FAAEAYCDSDE-------ACVRTA---IDWLRNRR-PDKPFCLYLPLIFPHppygVEEPWFSmidrEKLPPrrP 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 257 GYSDWQ--FSSVEFCGSSGRGGTGDA------------VQELDDAVGQLLASVKRAGAERKTITFFTSDngnpeYGDMLG 322
Cdd:cd16150 168 PGLRAKgkPSMLEGIEKQGLDRWSEErwrelratylgmVSRLDHQFGRLLEALKETGLYDDTAVFFFSD-----HGDYTG 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 323 NLPLrgykASNWEGG-----VREPAIVRWPGRIAAGVTSwALATTYDIYPTVMRLAGgsMPPGRVYDGKDLSAVLLSGAS 397
Cdd:cd16150 243 DYGL----VEKWPNTfedclTRVPLIIKPPGGPAGGVSD-ALVELVDIPPTLLDLAG--IPLSHTHFGRSLLPVLAGETE 315
|
410 420 430
....*....|....*....|....*....|....*....
gi 551540866 398 TPHACLFhwhdSElgqGGRGLSAVRC---GDYKAHFYTQ 433
Cdd:cd16150 316 EHRDAVF----SE---GGRLHGEEQAmegGHGPYDLKWP 347
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
62-427 |
7.34e-21 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 95.53 E-value: 7.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 62 AIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTARLPVR-------LGLGDGVLapdatgglqlnetTMAETLRRLG 134
Cdd:cd16156 23 AMKTPNLDRLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTngswtncMALGDNVK-------------TIGQRLSDNG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 135 YATAMFGKWHLGqreqylphnrGFDiYFGIPFsCDMGcgaWHGPH--PTRCFPSPLP----LLSCATGSVAKVEEQPTNL 208
Cdd:cd16156 90 IHTAYIGKWHLD----------GGD-YFGNGI-CPQG---WDPDYwyDMRNYLDELTeeerRKSRRGLTSLEAEGIKEEF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 209 aTLTQRYADFGAAFIANHSaaDRPWFLFASFNHVH------------VTDANYSK--------ANPPPGYSDWqfsSVEF 268
Cdd:cd16156 155 -TYGHRCTNRALDFIEKHK--DEDFFLVVSYDEPHhpflcpkpyasmYKDFEFPKgenayddlENKPLHQRLW---AGAK 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 269 CGSSGRGGTGDAVQEL------DDAVGQLLASVKRAGAErkTITFFTSDngnpeYGDMLGNLPLRGYKASNWEGGVREPA 342
Cdd:cd16156 229 PHEDGDKGTIKHPLYFgcnsfvDYEIGRVLDAADEIAED--AWVIYTSD-----HGDMLGAHKLWAKGPAVYDEITNIPL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 343 IVRWPGRIAAGVTSWALATTYDIYPTVMRLAGGSMPPgrVYDGKDLSAVLLSGASTPHACLFhwhdSELGQ------GGR 416
Cdd:cd16156 302 IIRGKGGEKAGTVTDTPVSHIDLAPTILDYAGIPQPK--VLEGESILATIEDPEIPENRGVF----VEFGRyevdhdGFG 375
|
410
....*....|....
gi 551540866 417 GLSAVRC---GDYK 427
Cdd:cd16156 376 GFQPVRCvvdGRYK 389
|
|
| Sulfatase_C |
pfam14707 |
C-terminal region of aryl-sulfatase; |
399-533 |
8.02e-20 |
|
C-terminal region of aryl-sulfatase;
Pssm-ID: 405407 [Multi-domain] Cd Length: 122 Bit Score: 85.06 E-value: 8.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 399 PHACLFHWHDSELgqggrglSAVRCGDYKAHFYTQN--DYATEANRSKSWPAGKQDPPLLFLLTqTEQSETVQVDPASEE 476
Cdd:pfam14707 2 PHEFLFHYCGAAL-------HAVRWGPYKAHFFTPSfdPPGAEGCYGSKVPVTHHDPPLLFDLE-RDPSEKYPLSPDSPE 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 551540866 477 YASHMKVIGRARDAHLASIAPVCSQNKASECGGTNWSYAVCadhdskskfPQWPLCT 533
Cdd:pfam14707 74 YPEVLAEIKAAVEEHKATLVPVPNQLSKGNYLWDPWLQPCC---------PTFPACT 121
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
32-380 |
1.54e-12 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 69.11 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 32 PNVLLLFADDLGinqanipGQpLSYTGVSGAIKTPNLAKMASEGTTFMQWYSAFHVCTPSRASLMTArlpvrlglgdgvL 111
Cdd:cd16171 1 PNVVMVMSDSFD-------GR-LTFRPGNQVVDLPYINFMKQHGSVFLNAYTNSPICCPSRAAMWSG------------L 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 112 APDAT------GGLQLNETTMAETLRRLGYATAMFGKWHLGQREQYLPhNRgfdiyfgipfscdmgCGAWhgphpTRCFP 185
Cdd:cd16171 61 FTHLTeswnnyKGLDPNYPTWMDRLEKHGYHTQKYGKLDYTSGHHSVS-NR---------------VEAW-----TRDVP 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 186 -------SPLPLL--SCATGSVAKVEEQPTNLATLTQRYAdfgaafIANHSaadRPWFLFASFNHVHVTDANYSKANppp 256
Cdd:cd16171 120 fllrqegRPTVNLvgDRSTVRVMLKDWQNTDKAVHWIRKE------APNLT---QPFALYLGLNLPHPYPSPSMGEN--- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 257 gysdwqFSSVEfcgsSGRGGTGDAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGNpeygdmLGNLPLRGYKASNWEG 336
Cdd:cd16171 188 ------FGSIR----NIRAFYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSDHGE------LAMEHRQFYKMSMYEG 251
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 551540866 337 GVREPAIVRWPGrIAAGVTSWALATTYDIYPTVMRLAGGSMPPG 380
Cdd:cd16171 252 SSHVPLLIMGPG-IKAGQQVSDVVSLVDIYPTMLDIAGVPQPQN 294
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
28-388 |
5.93e-07 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 52.35 E-value: 5.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 28 PAPPPNVLLL----FADDLgINqANIPGQPLsytgvsgaikTPNLAKMASEGTTFMQWYSafHVCTPSRA--SLMTARLP 101
Cdd:COG1368 231 PAKKPNVVVIllesFSDFF-IG-ALGNGKDV----------TPFLDSLAKESLYFGNFYS--QGGRTSRGefAVLTGLPP 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 102 VRlglGDGVLAPDATGGLQlnetTMAETLRRLGYATAMF--GKWHLGQREQYLPHNrGFDIYFGIPFSCDMGCGAWHgph 179
Cdd:COG1368 297 LP---GGSPYKRPGQNNFP----SLPSILKKQGYETSFFhgGDGSFWNRDSFYKNL-GFDEFYDREDFDDPFDGGWG--- 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 180 ptrcfpsplpllscatgsvakveeqptnlatltqrYAD--FGAAFIANHSAADRPWFLFA--SFNHV--HVTDANYSKAN 253
Cdd:COG1368 366 -----------------------------------VSDedLFDKALEELEKLKKPFFAFLitLSNHGpyTLPEEDKKIPD 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 254 PPPGYSDWQFSsvefcgssgrggtgdAVQELDDAVGQLLASVKRAGAERKTITFFTSDNGNPEYGDMLGNLPLRGYKAsn 333
Cdd:COG1368 411 YGKTTLNNYLN---------------AVRYADQALGEFIEKLKKSGWYDNTIFVIYGDHGPRSPGKTDYENPLERYRV-- 473
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 551540866 334 weggvrePAIVRWPGRIAAGVTSwALATTYDIYPTVMRLAGGSMPPGRVYdGKDL 388
Cdd:COG1368 474 -------PLLIYSPGLKKPKVID-TVGSQIDIAPTLLDLLGIDYPSYYAF-GRDL 519
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
65-374 |
1.42e-05 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 46.91 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 65 TPNLAKMASEGTTFMQWYSAFHVCTPSRA--SLMTARLPVRLGLGDGVLAPDAtgglqlNETTMAETLRRLGYATAMFgk 142
Cdd:cd16015 26 TPNLNKLAKEGLYFGNFYSPGFGGGTANGefEVLTGLPPLPLGSGSYTLYKLN------PLPSLPSILKEQGYETIFI-- 97
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 143 wHLGQ-----REQYLPHNrGFDIYFGIPfscDMgcgawhgPHPTRCFPSP-----------LPLLScatgsvaKVEEQPT 206
Cdd:cd16015 98 -HGGDasfynRDSVYPNL-GFDEFYDLE---DF-------PDDEKETNGWgvsdeslfdqaLEELE-------ELKKKPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 207 NLATLTqryadfgaafIANHSaadrPWflfasfnhvhvtDANYSKANPPPGYSDWQFSSVEFCGssgrggtgdAVQELDD 286
Cdd:cd16015 159 FIFLVT----------MSNHG----PY------------DLPEEKKDEPLKVEEDKTELENYLN---------AIHYTDK 203
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250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551540866 287 AVGQLLASVKRAGAERKTITFFtsdngnpeYGDMLGNLPLRGYKASNWEGGVRE-PAIVRWPGRIAAGVTSwALATTYDI 365
Cdd:cd16015 204 ALGEFIEKLKKSGLYENTIIVI--------YGDHLPSLGSDYDETDEDPLDLYRtPLLIYSPGLKKPKKID-RVGSQIDI 274
|
....*....
gi 551540866 366 YPTVMRLAG 374
Cdd:cd16015 275 APTLLDLLG 283
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