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Conserved domains on  [gi|551100837|gb|ERT32149|]
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CRISPR-associated endonuclease cas1 [Fusobacterium nucleatum CTI-5]

Protein Classification

CRISPR-Cas system spacer integrase Cas1( domain architecture ID 10176711)

CRISPR-Cas system spacer integrase Cas1 similar to those of subtype I-B, acts as a dsDNA endonuclease and is involved in the integration of spacer DNA into the CRISPR cassette

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cas1_I-B cd09722
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 4-326 1.23e-146

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


:

Pssm-ID: 187853  Cd Length: 320  Bit Score: 415.84  E-value: 1.23e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   4 TKYITSMGELSRKDNSLCFRKNGKNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQYNS 83
Cdd:cd09722    1 TYYIFSDGTLKRKENTLYFENEGEKKYIPVENIDEIYVFGEVSLNSKALSFLSKKGIPIHFFNYYGYYSGSFYPRESLNS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  84 GKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLYhYYKHGKSEVRDCIDWIREELyelvDKTESVKELLAYEGEIWM 161
Cdd:cd09722   81 GYLIVKQVEHYLDSekRLELARSFVEGAAHNMRRVLK-YYKDRGDDLDDYLDEIEEQK----ESANSINELMGVEGNIRK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 162 KFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKPI 241
Cdd:cd09722  156 TYYSAFDEILKDEFRFEKRTRRPPKNELNALISFGNSLLYTTVLSEIYKTHLNPTISYLHEPSERRFSLALDIAEIFKPI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 242 IVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKNILEDK 321
Cdd:cd09722  236 IVDRLIFRLVNKKIIK-EKHFEKDLNGVLLNEEGRKKFVKEFEEKLKTTIKHRKLKRKVSYRRLIRLELYKLIKHLLGEE 314


                 ....*
gi 551100837 322 EFIPF 326
Cdd:cd09722  315 EYKPF 319
 
Name Accession Description Interval E-value
Cas1_I-B cd09722
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 4-326 1.23e-146

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187853  Cd Length: 320  Bit Score: 415.84  E-value: 1.23e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   4 TKYITSMGELSRKDNSLCFRKNGKNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQYNS 83
Cdd:cd09722    1 TYYIFSDGTLKRKENTLYFENEGEKKYIPVENIDEIYVFGEVSLNSKALSFLSKKGIPIHFFNYYGYYSGSFYPRESLNS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  84 GKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLYhYYKHGKSEVRDCIDWIREELyelvDKTESVKELLAYEGEIWM 161
Cdd:cd09722   81 GYLIVKQVEHYLDSekRLELARSFVEGAAHNMRRVLK-YYKDRGDDLDDYLDEIEEQK----ESANSINELMGVEGNIRK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 162 KFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKPI 241
Cdd:cd09722  156 TYYSAFDEILKDEFRFEKRTRRPPKNELNALISFGNSLLYTTVLSEIYKTHLNPTISYLHEPSERRFSLALDIAEIFKPI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 242 IVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKNILEDK 321
Cdd:cd09722  236 IVDRLIFRLVNKKIIK-EKHFEKDLNGVLLNEEGRKKFVKEFEEKLKTTIKHRKLKRKVSYRRLIRLELYKLIKHLLGEE 314


                 ....*
gi 551100837 322 EFIPF 326
Cdd:cd09722  315 EYKPF 319
cas1_HMARI TIGR03641
CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP; The CRISPR-associated protein ...
 3-326 1.69e-145

CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.


Pssm-ID: 274695  Cd Length: 320  Bit Score: 412.77  E-value: 1.69e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837    3 STKYITSMGELSRKDNSLCFRKNGKNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQYN 82
Cdd:TIGR03641   1 KTYYIFSDGRLKRKENTLYFENKDEKKYIPVENIDEIYVFGEVSLNSKALSFLSKKGIPIHFFNYYGYYSGSFYPRESLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   83 SGKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLyHYYKHGKSEvrdcIDWIrEELYELVDKTESVKELLAYEGEIW 160
Cdd:TIGR03641  81 SGYLIVKQVEHYLDSekRLELARSFVEGAAHNMRRVL-KYYKKRGKD----LDKI-EAYLESLKEAKSINELMGVEGNIR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  161 MKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKP 240
Cdd:TIGR03641 155 KTYYSAFDEILPKGFRFEKRTRRPPKNELNALISFGNSLLYTTVLSEIYKTHLNPTISYLHEPSERRFSLALDIAEIFKP 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  241 IIVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKNILED 320
Cdd:TIGR03641 235 IIVDRLIFRLVNKKIIK-EKHFEKDLNGVLLNEEGRKKFIKEFEEKLKTTIKHRKLKRKVSYRRLIRLELYKLIKHLLGE 313


                  ....*.
gi 551100837  321 KEFIPF 326
Cdd:TIGR03641 314 EEYKPF 319
Cas1 COG1518
CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated ...
 4-329 1.17e-120

CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated integrase Cas1 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 441127  Cd Length: 329  Bit Score: 350.27  E-value: 1.17e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   4 TKYITSMG-ELSRKDNSLCFRKNGKNI-YIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQY 81
Cdd:COG1518    1 TLYITEPGaYLSRKGNTLVVEKEDEEKkRVPLEDIEQIVLFGEVSLSTALLRFLAENGIPVHFLDYYGRYLGRLLPRESG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  82 NSGKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLYHYYKHGKSEVRDCIDWIrEELYELVDKTESVKELLAYEGEI 159
Cdd:COG1518   81 GNVLLRRAQYQAYLDEekRLALARSIVRGKIRNQRAVLRRYGRRRKEDLEEAIERL-EELLKRLEEADSIDELRGIEGNA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 160 WMKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFK 239
Cdd:COG1518  160 ARIYFSALDGLLPEDFRFEGRSRRPPRDPVNALLSFGYTLLYSDVLSAIYAAGLDPYIGFLHEPRPGRPSLALDLMEEFR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 240 PIIVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKNILE 319
Cdd:COG1518  240 PILVDRLVLSLINRGQIT-PKDFEKELGGVLLTEEGRKKFLEAFEERLQETIKHPFLGRKVSYRRLIRLQARKLAKHLRG 318

                        330
                 ....*....|.
gi 551100837 320 DK-EFIPFSLK 329
Cdd:COG1518  319 ELdEYPPFVLR 329
Cas_Cas1 pfam01867
CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats ...
 6-285 2.16e-109

CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.


Pssm-ID: 460366  Cd Length: 283  Bit Score: 319.79  E-value: 2.16e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837    6 YITSMGE-LSRKDNSLCFRKNGKNI-YIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKnQYNS 83
Cdd:pfam01867   2 YVTTPGAyLSRKGETLVVEKEGEEKkRIPLEDVEQIVIFGNVSISTAALRLLAERGIPVHFLSYYGRYLGRLYPE-VSGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   84 GKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLYHYYK-HGKSEVRDCIDWIREELYELvDKTESVKELLAYEGEIW 160
Cdd:pfam01867  81 VLLRRAQYRAYDDEekRLELARSFVAGKLRNQRTVLRRYNRdRKDEALEEAIEELEELLKKL-ERADSIDELRGIEGNAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  161 MKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKP 240
Cdd:pfam01867 160 RAYFSAFDELLPKEFGFEGRSRRPPLDPVNALLSFGYTLLYSDVLSALEAVGLDPYIGFLHEDRPGRPSLALDLMEEFRP 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 551100837  241 IIVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFEN 285
Cdd:pfam01867 240 VIVDRLVLSLINRGQIT-PKDFEKRENGVLLNDEGRKKFLKAYEE 283
 
Name Accession Description Interval E-value
Cas1_I-B cd09722
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 4-326 1.23e-146

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187853  Cd Length: 320  Bit Score: 415.84  E-value: 1.23e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   4 TKYITSMGELSRKDNSLCFRKNGKNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQYNS 83
Cdd:cd09722    1 TYYIFSDGTLKRKENTLYFENEGEKKYIPVENIDEIYVFGEVSLNSKALSFLSKKGIPIHFFNYYGYYSGSFYPRESLNS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  84 GKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLYhYYKHGKSEVRDCIDWIREELyelvDKTESVKELLAYEGEIWM 161
Cdd:cd09722   81 GYLIVKQVEHYLDSekRLELARSFVEGAAHNMRRVLK-YYKDRGDDLDDYLDEIEEQK----ESANSINELMGVEGNIRK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 162 KFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKPI 241
Cdd:cd09722  156 TYYSAFDEILKDEFRFEKRTRRPPKNELNALISFGNSLLYTTVLSEIYKTHLNPTISYLHEPSERRFSLALDIAEIFKPI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 242 IVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKNILEDK 321
Cdd:cd09722  236 IVDRLIFRLVNKKIIK-EKHFEKDLNGVLLNEEGRKKFVKEFEEKLKTTIKHRKLKRKVSYRRLIRLELYKLIKHLLGEE 314


                 ....*
gi 551100837 322 EFIPF 326
Cdd:cd09722  315 EYKPF 319
cas1_HMARI TIGR03641
CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP; The CRISPR-associated protein ...
 3-326 1.69e-145

CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.


Pssm-ID: 274695  Cd Length: 320  Bit Score: 412.77  E-value: 1.69e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837    3 STKYITSMGELSRKDNSLCFRKNGKNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQYN 82
Cdd:TIGR03641   1 KTYYIFSDGRLKRKENTLYFENKDEKKYIPVENIDEIYVFGEVSLNSKALSFLSKKGIPIHFFNYYGYYSGSFYPRESLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   83 SGKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLyHYYKHGKSEvrdcIDWIrEELYELVDKTESVKELLAYEGEIW 160
Cdd:TIGR03641  81 SGYLIVKQVEHYLDSekRLELARSFVEGAAHNMRRVL-KYYKKRGKD----LDKI-EAYLESLKEAKSINELMGVEGNIR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  161 MKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKP 240
Cdd:TIGR03641 155 KTYYSAFDEILPKGFRFEKRTRRPPKNELNALISFGNSLLYTTVLSEIYKTHLNPTISYLHEPSERRFSLALDIAEIFKP 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  241 IIVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKNILED 320
Cdd:TIGR03641 235 IIVDRLIFRLVNKKIIK-EKHFEKDLNGVLLNEEGRKKFIKEFEEKLKTTIKHRKLKRKVSYRRLIRLELYKLIKHLLGE 313


                  ....*.
gi 551100837  321 KEFIPF 326
Cdd:TIGR03641 314 EEYKPF 319
Cas1 COG1518
CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated ...
 4-329 1.17e-120

CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated integrase Cas1 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 441127  Cd Length: 329  Bit Score: 350.27  E-value: 1.17e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   4 TKYITSMG-ELSRKDNSLCFRKNGKNI-YIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQY 81
Cdd:COG1518    1 TLYITEPGaYLSRKGNTLVVEKEDEEKkRVPLEDIEQIVLFGEVSLSTALLRFLAENGIPVHFLDYYGRYLGRLLPRESG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  82 NSGKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLYHYYKHGKSEVRDCIDWIrEELYELVDKTESVKELLAYEGEI 159
Cdd:COG1518   81 GNVLLRRAQYQAYLDEekRLALARSIVRGKIRNQRAVLRRYGRRRKEDLEEAIERL-EELLKRLEEADSIDELRGIEGNA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 160 WMKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFK 239
Cdd:COG1518  160 ARIYFSALDGLLPEDFRFEGRSRRPPRDPVNALLSFGYTLLYSDVLSAIYAAGLDPYIGFLHEPRPGRPSLALDLMEEFR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 240 PIIVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKNILE 319
Cdd:COG1518  240 PILVDRLVLSLINRGQIT-PKDFEKELGGVLLTEEGRKKFLEAFEERLQETIKHPFLGRKVSYRRLIRLQARKLAKHLRG 318

                        330
                 ....*....|.
gi 551100837 320 DK-EFIPFSLK 329
Cdd:COG1518  319 ELdEYPPFVLR 329
Cas_Cas1 pfam01867
CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats ...
 6-285 2.16e-109

CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.


Pssm-ID: 460366  Cd Length: 283  Bit Score: 319.79  E-value: 2.16e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837    6 YITSMGE-LSRKDNSLCFRKNGKNI-YIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKnQYNS 83
Cdd:pfam01867   2 YVTTPGAyLSRKGETLVVEKEGEEKkRIPLEDVEQIVIFGNVSISTAALRLLAERGIPVHFLSYYGRYLGRLYPE-VSGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   84 GKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLYHYYK-HGKSEVRDCIDWIREELYELvDKTESVKELLAYEGEIW 160
Cdd:pfam01867  81 VLLRRAQYRAYDDEekRLELARSFVAGKLRNQRTVLRRYNRdRKDEALEEAIEELEELLKKL-ERADSIDELRGIEGNAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  161 MKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKP 240
Cdd:pfam01867 160 RAYFSAFDELLPKEFGFEGRSRRPPLDPVNALLSFGYTLLYSDVLSALEAVGLDPYIGFLHEDRPGRPSLALDLMEEFRP 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 551100837  241 IIVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFEN 285
Cdd:pfam01867 240 VIVDRLVLSLINRGQIT-PKDFEKRENGVLLNDEGRKKFLKAYEE 283
Cas1_I-II-III cd09634
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 4-319 6.24e-104

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187766  Cd Length: 317  Bit Score: 307.23  E-value: 6.24e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   4 TKYITS-MGELSRKDNSLCFRKNGKNI-YIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQY 81
Cdd:cd09634    2 TLYITTpGAYLSRKGNRLVVEKEDEKKkRIPLEDIDSIVIFGNVSISTAALRLLAENGIPVHFLDYYGRYLGRLYPPEGG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  82 NSGKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIDEVLYHYYKHGKSEVRDCIdwIREELYELVDKTESVKELLAYEGEI 159
Cdd:cd09634   82 RSVLLRRAQYEAYLDPekRLELAREIVRGKIRNQRRVLKRYARDGKELLLALA--ELEELLEKLDKAKSIEELRGIEGNA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 160 WMKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFK 239
Cdd:cd09634  160 AKIYFEALFQLLPKEFRFEGRSRRPPKDPVNALLSYGYSLLYSAVLSAIVAAGLDPYIGFLHEDRPGRPSLALDLMEEFR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 240 PIIVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYtKLNRKISYRTAIKLDCYKLIKNILE 319
Cdd:cd09634  240 PIIVDRLVLSLINKGQIK-KKDFEKELGGVLLTEEGRKKLIEALEERLKETIKH-YLGRKVSYRRLIRLQAYKLAKHLRG 317
cas1 TIGR00287
CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the ...
 6-325 4.50e-88

CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease.


Pssm-ID: 272998  Cd Length: 323  Bit Score: 267.29  E-value: 4.50e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837    6 YITSMGE-LSRKDNSLCFRK-NGKNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQYNS 83
Cdd:TIGR00287   3 YVLEYGSyLSRKGNTLVVEKeGKKKWNIPVANVDCIVLFGGVSISSAAIRLLAKRGIDIVFFGGDGNYVGRLSPQESGST 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   84 GKLLVKQVEKYKNN--RIDIAKAIVKGIGTNIdEVLYHYYKHGKSEVRDCIDWIREELYELvDKTESVKELLAYEGEIWM 161
Cdd:TIGR00287  83 VELRLAQVKAYLDEekRLKLAKEFVSGKIANQ-AALLKYLTRRREDLRSYLEEYESLMKEL-ASADSIEELMGIEGNAAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  162 KFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKPI 241
Cdd:TIGR00287 161 AYYAALAQLLPDEFGFNGRSKRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDLMEEFKPQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  242 IVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKNILEDK 321
Cdd:TIGR00287 241 IVDRLVFSLINRNIIT-EEDFEKISNGVYLGEEGRKKFLQAFEERLQTTVTHPGLNRRVSYLDIIILQARKLAKALRGEE 319


                  ....
gi 551100837  322 EFIP 325
Cdd:TIGR00287 320 RYRP 323
Cas1_I-II-III cd09636
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 6-262 2.44e-64

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187767  Cd Length: 260  Bit Score: 204.07  E-value: 2.44e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   6 YITSMGE-LSRKDNSLCFRKNGKN-IYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQYNS 83
Cdd:cd09636    2 YVLEYGSyLSRKGNTLVVEKEGELkKNIPVANVDCIVIFGGVSISSAAIRELAKRGIDIVFLGGDGNYLGRLYPPEPGSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  84 GKLLVKQVEKYKN--NRIDIAKAIVKGIGTNIdEVLYHYYKHGKSEVRDCIDWIREELYELVDKTESVKELLAYEGEIWM 161
Cdd:cd09636   82 VFTRRAQYKAYLNpaKRLKLAREFVEGKLANQ-AALLRYLTRRREDLKSELAEYIAELLKELDNANSIEELMGIEGNAAR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 162 KFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKPI 241
Cdd:cd09636  161 AYYAALAQLLPDEFGFNGRSRRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDLMEEFRPQ 240

                        250       260
                 ....*....|....*....|.
gi 551100837 242 IVYKTIFDLVNNKRIKvAKHF 262
Cdd:cd09636  241 IVDRLVFSLINRGIIT-PEDF 260
cas1_CYANO TIGR04093
CRISPR-associated endonuclease Cas1, subtype CYANO; The CRISPR-associated protein Cas1 is ...
 3-329 2.80e-55

CRISPR-associated endonuclease Cas1, subtype CYANO; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.


Pssm-ID: 274976  Cd Length: 323  Bit Score: 183.01  E-value: 2.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837    3 STKYITSMGELSRKDNSLCFRKN----GKNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPK 78
Cdd:TIGR04093   1 STLYITQPDAKISKDDGRIIVVDsdgeEKVASFPLIKVETIVVFGEATLTTPALAHLLERGIVLHYLTRFGKYFGSLVPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   79 NQYNsGKLLVKQVEKY--KNNRIDIAKAIVKGIGTNIDEVLYhyyKHGKSEVRdcidwiREELYELVDKTESVKELLAYE 156
Cdd:TIGR04093  81 LTRN-TILRVAQHQAHisPQQRLAIAREIVRGKLRNSRTMLY---RRGRKQTK------IPELEKPVDDKNSLDSLRGLE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  157 GEIWMKFYSMFQYFINEDFVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISE 236
Cdd:TIGR04093 151 GEAAAIYFGCLSDLLPDEWSFHGRTRRPPTDPVNALLSLGYALLRTQVLSALRIVGLDPYIGFLHVDRHGRPALALDLME 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  237 VFKPIIVYKTIFDLVNNKRIKvAKHFEKSLNYCILNEEGRQIFIEAFENRIETTFLYTKLNRKISYRTAIKLDCYKLIKN 316
Cdd:TIGR04093 231 EFRPIIVDAVVLRLINRKMLK-PKDFQEEPGAVRLKDEAFKLFLGKFEEKMQSEFKHPIFKYKVSYRRAIELQARLLAKA 309

                         330
                  ....*....|....
gi 551100837  317 ILED-KEFIPFSLK 329
Cdd:TIGR04093 310 LMGEiKEYPPLIIR 323
cas1_DVULG TIGR03640
CRISPR-associated endonuclease Cas1, subtype I-C/DVULG; The CRISPR-associated protein Cas1 is ...
 4-302 1.16e-27

CRISPR-associated endonuclease Cas1, subtype I-C/DVULG; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.


Pssm-ID: 188360  Cd Length: 340  Bit Score: 110.41  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837    4 TKYITSMGELSRKDN-SLCFRKNG-KNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNqy 81
Cdd:TIGR03640   5 TLYVTTQGTYLHKDGeTVVVEVEGeKKARVPLHHLGGIVCFGNVGLSPFLMGRCAEDGISLVFLTENGRFLARVEGPV-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   82 nSGKLLVKQvEKYK-----NNRIDIAKAIVKGIGTNIDEVLYHYYK-HGKSEVRDCIDWIREELYELVDK---TESVKEL 152
Cdd:TIGR03640  83 -SGNVLLRR-AQYRaaddpERSLAIARSIVAGKIRNARQVLLRAARdHGEEDDAAALEAAADRLAVALRRlqrADDLDSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  153 LAYEGEIWMKFYSMFQYFINED---FVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFS 229
Cdd:TIGR03640 161 RGIEGEAARLYFAVFDHLLRQDrpaFRFDGRSRRPPLDPVNALLSFLYTLLTHDCRSALEGVGLDPAVGFLHRDRPGRPS 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551100837  230 LSLDISEVFKPIIVYKTIFDLVNNKRIKvAKHFEKSLN-YCILNEEGRQIFIEAFENRIETTFLYTKLNRKISY 302
Cdd:TIGR03640 241 LALDLMEEFRAVLADRLALSLINRGQLT-AKDFEVREGgAVLLTDDARKTVLVAYQERKQEEILHPFLGEKVPL 313
Cas1_I-C cd09721
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 4-302 1.48e-27

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187852  Cd Length: 338  Bit Score: 110.02  E-value: 1.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   4 TKYITSMGELSRKDN-SLCFRKNG-KNIYIPIENTKEIYCLNEIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNqy 81
Cdd:cd09721    4 TLYVTTQGTYLHKDGeTVVVEVEGeKKARVPLHHLGGIVCFGNVGLSPFLMGRCAEDGISLVFLTENGRFLARVEGPV-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  82 nSGKLLVKQvEKYK-----NNRIDIAKAIVKGIGTNIDEVLYHYYK-HGKSEVRDCIDWIREELYELVDK---TESVKEL 152
Cdd:cd09721   82 -SGNVLLRR-AQYRaaddpERSLAIARSIVAGKIRNARQVLLRAARdHGEEDDRAALEAAADRLAVALRRlqrADDLDEL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 153 LAYEGEIWMKFYSMFQYFINED---FVLNKRVKRPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFS 229
Cdd:cd09721  160 RGIEGEAARLYFAVFDHLLRQDapaFRFDGRSRRPPLDPVNALLSFLYTLLTHDCRSALEGVGLDPAVGFLHRDRPGRPS 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551100837 230 LSLDISEVFKPIIVYKTIFDLVNNKRIKvAKHFEKSLN-YCILNEEGRQIFIEAFENRIETTFLYTKLNRKISY 302
Cdd:cd09721  240 LALDLMEEFRAVLADRLALSLINRGQLT-AKDFEVREGgAVLLTDDARKTVLVAYQERKQEEITHPFLGEKVPL 312
Cas1_II cd09720
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
 6-275 2.02e-07

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.


Pssm-ID: 187851  Cd Length: 275  Bit Score: 51.48  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837   6 YITSMGELSRKDNSLCFRKNGKNIYIPIENTKEIYCLN-EIILNSKLLDFLGRNNIIVHFFNYYGGYSGSFYPKNQY-NS 83
Cdd:cd09720    5 EISNHEKLSLKLNQLVVKKDNGRITLPLEDIDVILIENpQVTISAALLNALAENNIALIFCDEKHLPVGQLLPFYGHhRS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837  84 GKLLVKQVEKYKNNRIDIAKAIVKGIGTNIDEVLYHYykHGKSEVRDCIDWIREelYELVDKTEsvKELLAyegeiwMKF 163
Cdd:cd09720   85 LKRLKLQIKWSDPFKKRLWQKIIKQKILNQAFVLEKL--GIFEDAEKLKNLANK--VESGDKTN--REAHA------AKL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551100837 164 YsmFQYFINEDFVLNkrvkrPPDNPINALISFGNTLLYTKTISAIYRTHLDQRISFLHEPSEGRFSLSLDISEVFKPI-- 241
Cdd:cd09720  153 Y--FKTLFGEDFSRD-----DNGDPINAALNYGYSILRSAVARALVKAGLLPRLGIFHKSEYNPFNLADDLMEPFRPLvd 225

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 551100837 242 -IVYKTIFDLVNNKRIKVAKHFEKSLNY-CILNEEG 275
Cdd:cd09720  226 yLVYELLFESREELFKEIKRKLFSILNEkIIYNGKG 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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