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Conserved domains on  [gi|550822324|ref|NP_001272452|]
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mu-type opioid receptor isoform MOR-1A2 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606795)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
71-349 0e+00

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


:

Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 526.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd15090   81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 310
Cdd:cd15090  161 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 311 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15090  241 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
 
Name Accession Description Interval E-value
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
71-349 0e+00

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 526.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd15090   81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 310
Cdd:cd15090  161 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 311 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15090  241 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
87-338 1.06e-68

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 217.94  E-value: 1.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324   87 GNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYNMFTSIFTLCTMS 164
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  165 VDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYR--QGSIDCTLTFSHPTWYWEnLLKICVFIFA 242
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpeGNVTVCFIDFPEDLSKPV-SYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  243 FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE-TTFQTVSWH 321
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElSRLLDKALS 239
                         250
                  ....*....|....*..
gi 550822324  322 FCIALGYTNSCLNPVLY 338
Cdd:pfam00001 240 VTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
69-351 1.47e-41

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 149.54  E-value: 1.47e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  69 TAITIMALYSIVCVVGLFGNFLVMYVIvRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIYVL-TKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW 228
Cdd:PHA03087 118 YYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTM 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsGSKEKDRNLRRItRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:PHA03087 198 NWKLFINFEINIIGMLIPLTILLYCYSKILITLK------GINKSKKNKKAI-KLVLIIVILFVIFWLPFNVSVFVYSLH 270
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 309 TIPETT------FQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE 351
Cdd:PHA03087 271 ILHFKSgckavkYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK 319
 
Name Accession Description Interval E-value
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
71-349 0e+00

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 526.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd15090   81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 310
Cdd:cd15090  161 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 311 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15090  241 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
71-349 1.84e-154

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 437.46  E-value: 1.84e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15089    1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY-RQGSIDCTLTFSHPTWY 229
Cdd:cd15089   81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTpRDGAVVCMLQFPSPSWY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15089  161 WDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVD 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 310 IPETTFQTV-SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15089  241 IDRRNPLVVaALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
71-349 1.01e-147

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 420.55  E-value: 1.01e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATT-KYRQGSIDCTLTFSHPTWY 229
Cdd:cd14970   81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTlQEEGGTISCNLQWPDPPDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS--GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd14970  161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLStsGAREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 308 VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14970  241 IDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
71-349 1.50e-143

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 410.11  E-value: 1.50e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15091    1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ--GSIDCTLTF-SHPT 227
Cdd:cd15091   81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREdvDSTECSLQFpDDDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15091  161 SWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEAL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 308 VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15091  241 GSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
71-349 4.81e-136

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 390.77  E-value: 4.81e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15092    1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd15092   81 YNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQDYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 310
Cdd:cd15092  161 DPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQ 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 311 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15092  241 PSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
71-349 3.62e-89

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 271.26  E-value: 3.62e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15093    1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ-GSIDCTLTFSHPTWY 229
Cdd:cd15093   81 INMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQdGSSACNMQWPEPAAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15093  161 WSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQ 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15093  241 LPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
71-349 6.06e-79

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 245.21  E-value: 6.06e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15970    1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15970   81 INMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPiIIFSNTAPNSDGSVACNMQMPEPSQR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15970  161 WLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 IPETTFQTVSwhfcIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15970  241 QHDATVSQLS----VILGYANSCANPILYGFLSDNFKRSF 276
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
71-349 1.26e-77

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 241.68  E-value: 1.26e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15973    1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQG-SIDCTLTFSHPTwy 229
Cdd:cd15973   81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGqAVACNLIWPHPA-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15973  159 WSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLP 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 IPETTFQtvswHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15973  239 RLDATVN----HASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
73-349 1.37e-74

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 233.97  E-value: 1.37e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 152
Cdd:cd15971    3 LTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWEN 232
Cdd:cd15971   83 QFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPGESSAWYT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE 312
Cdd:cd15971  163 GFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISP 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 313 TTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15971  243 TPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
71-349 1.33e-71

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 226.54  E-value: 1.33e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15087    1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPV--KALDFRTPRNAKIINVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHPT 227
Cdd:cd15087   81 YNIFSSIYFLTVMSVDRYLVVLATVrsRRMPYRTYRAAKIVSLCVWLLVTIIVLPfTVFAGVYSNELGRKSCVLSFPSPE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15087  161 SLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALT 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 308 VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15087  241 TDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
73-349 8.91e-70

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 221.60  E-value: 8.91e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 152
Cdd:cd15974    3 IPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSidCTLTFSHPTWYWEN 232
Cdd:cd15974   83 QFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLNT--CNISWPEPVSVWST 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE 312
Cdd:cd15974  161 AFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVILPE 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 313 TTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15974  241 EPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
76-349 8.48e-69

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 219.27  E-value: 8.48e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15094    6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHP--------- 226
Cdd:cd15094   86 SSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSsavngqkaf 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TWYwenllkicVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIikA 306
Cdd:cd15094  166 TLY--------TFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQV--H 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 307 LVTIPETTfQTVSWHFCI-----ALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15094  236 LIFLPPGT-DMPKWEILMfllltVLSYANSMVNPLLYAFLSENFRKSF 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
87-338 1.06e-68

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 217.94  E-value: 1.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324   87 GNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYNMFTSIFTLCTMS 164
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  165 VDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYR--QGSIDCTLTFSHPTWYWEnLLKICVFIFA 242
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpeGNVTVCFIDFPEDLSKPV-SYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  243 FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE-TTFQTVSWH 321
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElSRLLDKALS 239
                         250
                  ....*....|....*..
gi 550822324  322 FCIALGYTNSCLNPVLY 338
Cdd:pfam00001 240 VTLWLAYVNSCLNPIIY 256
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
71-349 8.95e-66

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 211.20  E-value: 8.95e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15972    1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSidCTLTFSHPTWYW 230
Cdd:cd15972   81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGT--CHIAWPEPAQVW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSV--RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15972  159 RAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSgrRVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVC 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 309 TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15972  239 PLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
71-347 2.85e-65

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 210.00  E-value: 2.85e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISID 149
Cdd:cd15088    1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIdGQWYFGEVMCKIITALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTFSHPT- 227
Cdd:cd15088   81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVwVYSSLIYFPDGTTFCYVSLPSPDd 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWenlLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15088  161 LYW---FTIYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLA 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 308 VTIPETTFQtVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15088  238 MNRPTLAFE-VAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
71-349 9.41e-63

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 203.68  E-value: 9.41e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15096    1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADlLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSID--CTLTFSHPT 227
Cdd:cd15096   81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEaySYCTFLTEV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSG--SKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd15096  161 GTAAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGrrSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLK 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 306 ALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15096  241 YYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
73-341 3.41e-62

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 201.75  E-value: 3.41e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLvGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCtlTFSHPTWYWE 231
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCC--CLCWPDLTLS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFIMPVLIITVCYGLMILRLK-------SVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd00637  159 KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRrhrrrirSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 305 KALVTIPETTFQTVsWHFCIALGYTNSCLNPVLYAFL 341
Cdd:cd00637  239 DVFGPDPSPLPRIL-YFLALLLAYLNSAINPIIYAFF 274
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
75-349 2.72e-60

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 197.30  E-value: 2.72e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADlTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSidcTLTFSHPTW---YW 230
Cdd:cd14971   85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPG---NRTVCSEAWpsrAH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd14971  162 RRAFALCTFLFGYLLPLLLICVCYAAMLRHLwRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGP 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14971  242 FPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
71-349 1.51e-59

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 195.51  E-value: 1.51e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd14993    1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTF-----S 224
Cdd:cd14993   81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGTITIyicteD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSV-------RMLSGSKEK-DRNLRRITRMVLVVVAVFIVCWT 296
Cdd:cd14993  161 WPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRkppgdrgSANSTSSRRiLRSKKKVARMLIVVVVLFALSWL 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 297 PIHIYVIIKAL-VTIPETTFQTVS-WHFCIA-LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14993  241 PYYVLSILLDFgPLSSEESDENFLlILPFAQlLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
75-349 1.82e-56

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 187.49  E-value: 1.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVisidYYNM 153
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDlAFLVCCVPFTAALYATPSWVFGDFMCKFV----NYMM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSI----FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKyrQGSIDCTLTFSHPTW- 228
Cdd:cd15095   81 QVTVqatcLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLE--EGYWYGPQTYCREVWp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 --YWENLLKICVFIFAFIMPVLIITVCYGLMILRL---KSVRMLSGSKEKDRNL---RRITRMVLVVVAVFIVCWTPIHI 300
Cdd:cd15095  159 skAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLwrrSVDGNNQSEQLSERALrqkRKVTRMVIVVVVLFAICWLPNHV 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 550822324 301 YVIIKALVTIPETTFQTVSWH-FCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15095  239 LNLWQRFDPNFPETYATYALKiAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
71-349 1.24e-55

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 184.93  E-value: 1.24e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMK--TATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVIS 147
Cdd:cd15098    1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADlFFLLFCVPFQATIYSLPEWVFGAFMCKFVHY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDctLTFSHPT 227
Cdd:cd15098   81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASN--QTFCWEN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WY---WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVrMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHiyvII 304
Cdd:cd15098  159 WPekqQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKK-LKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHH---II 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 305 KALVTIPETTFQTVSWHFCIA---LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15098  235 HLWVEFGDFPLTQASFVLRITahcLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
75-347 2.38e-55

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 184.34  E-value: 2.38e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 154
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADG-WVFGSFLCKLVSALYTINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY-WENL 233
Cdd:cd14984   84 SGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTATtWKTL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGLMILRLKSvrmlSGSKEKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIKAL----VT 309
Cdd:cd14984  164 LRLLQNILGFLLPLLVMLFCYSRIIRTLLR----ARNHKKHRALRVI----FAVVVVFFLCWLPYNIVLLLDTLqllgII 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 310 IPETTFQT---VSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd14984  236 SRSCELSKsldYALQVTESLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
74-347 1.32e-54

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 182.46  E-value: 1.32e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYN 152
Cdd:cd14982    4 PIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGwWPFGDFLCRLTGLLFYIN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWEN 232
Cdd:cd14982   84 MYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASAA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMIlrlKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPihiYVIIKALVTIPE 312
Cdd:cd14982  164 PIVLIALVVGFLIPLLIILVCYSLII---RALRRRSKQSQKSVRKRKALRMILIVLAVFLVCFLP---YHVTRILYLLVR 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 313 TTFQT---------VSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd14982  238 LSFIAdcsarnslyKAYRITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
72-349 2.81e-54

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 180.84  E-value: 2.81e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLvALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 enllkICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALV-- 308
Cdd:cd14967  161 -----LVSSVISFFIPLLIMIVLYARIFRVAR--------RE-----LKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCpp 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 309 -TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14967  223 dCVPPILYAVFFW-----LGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
71-349 3.17e-53

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 178.65  E-value: 3.17e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYViVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID 149
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVIWV-AGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHhWPFGSVLCKLNSFVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLT-FSHPTW 228
Cdd:cd14974   80 SLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTcVEDYDL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 --YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSkekdRNLRRITRMvlvvVAVFIVCWTPIHIYVIIKA 306
Cdd:cd14974  160 rrSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAKSS----KPLRVLLAV----VVAFFLCWLPYHVFALLEL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 307 LVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14974  232 VAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
73-347 1.35e-52

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 177.19  E-value: 1.35e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYY 151
Cdd:cd14985    3 IPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANqYDWPFGAFLCKVSSYVISV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd14985   83 NMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACIMLYPHEAWH 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFIMPVLIITVCYGLMILRLKsvRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI- 310
Cdd:cd14985  163 FGLSLELNILGFVLPLLIILTCYFHIARSLR--KRYERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLg 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 311 -----PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd14985  241 airpcFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQ 282
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
71-349 1.59e-50

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 172.02  E-value: 1.59e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15203    1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLvSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIINVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTF---SH 225
Cdd:cd15203   81 GVSIFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLaIFQELSDVPIEILPYCGYFcteSW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKS-VRMLSGSKEKD--------RNLRRITRMVLVVVAVFIVCWT 296
Cdd:cd15203  159 PSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKrVKKKRGKRTLSsrrrrselRRKRRTNRLLIAMVVVFAVCWL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 297 PIHIYVII---KALVTIPETTFQTVSWhFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15203  239 PLNLFNLLrdfEPLPQIDGRHFYLIFL-ICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
75-349 1.65e-47

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 164.03  E-value: 1.65e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 153
Cdd:cd15168    5 IVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH---PTWYW 230
Cdd:cd15168   85 YGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPeelNDYVI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENllkICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHI----YVIIK 305
Cdd:cd15168  165 YS---MVLTGLGFLLPLLIILACYGLIVRALiRKLGEGVTSALR----RKSIRLVIIVLALFAVCFLPFHVtrtiNLAAR 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 306 AL-VTIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15168  238 LLsGTASCATLNGIYVAYKVTrpLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
77-349 1.25e-45

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 158.21  E-value: 1.25e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15001    6 YVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFcVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFIC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFmaTTKYRQGSIDCTLTFSH-----PTWYW 230
Cdd:cd15001   86 SVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLF--GQGLVRYESENGVTVYHcqkawPSTLY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLmilrlksvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 310
Cdd:cd15001  164 SRLYVVYLAIVIFFIPLIVMTFAYAR------------------DTRKQVIKMLISVVVLFAVCWGPLLIDNLLVSFDVI 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 311 PETTFQTV-SWHFCI-ALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15001  226 STLHTQALkYMRIAFhLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
71-349 3.48e-45

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 158.05  E-value: 3.48e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA--TNIYIFNLALADALATSTLPFQSVNY-LMGTWPFGTILCKIVIS 147
Cdd:cd14976    1 NLVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYaLDFVWPFGTAMCKVVRY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSID-CTLTF--- 223
Cdd:cd14976   81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTlCLLRFpkn 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 224 -SHPTWY-WENLLKICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGSkekdRNLRRITRMVLVVVAVFIVCWTPIHIY 301
Cdd:cd14976  161 sSVTRWYnWLGMYQLQKVVLGFFLPLGIITLSY-LLLLRFLQRKRGGSK----RRKSRVTKSVFIVVLSFFICWLPNQAL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 302 VIIKALV---TIPET----TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14976  236 SLWSALIkfdDVPFSdaffAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
71-349 4.46e-44

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 154.97  E-value: 4.46e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLfNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW- 228
Cdd:cd15202   81 YCSVHVSAYTLTAIAVDRYQAIMHPLKPR--ISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDWp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 ----YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSK-----EKDRNLRRITRMVLVVVAVFIVCWTPIH 299
Cdd:cd15202  159 eradLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATteryfALRRKKKKVIKMLMVVVVLFALCWLPFN 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 300 IYVIIKALVTIPETTFQTVSWhFCIA-LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15202  239 IYVLLLSSKPDYLIKTINAVY-FAFHwLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
71-349 5.19e-44

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 154.90  E-value: 5.19e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 149
Cdd:cd15192    1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEyHWPFGNFLCKIASALV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW- 228
Cdd:cd15192   81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVCAFHYPSQn 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 -YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNlrrITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15192  161 sTLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPRNDE---IFKMIMAVVLFFFFCWIPHQIFTFLDVL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 550822324 308 VT--------IPETTFQTVSWHFCIAlgYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15192  238 IQlkviqdchIADIVDTAMPFTICIA--YFNSCLNPILYGFVGKNFRKKF 285
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
73-348 6.60e-44

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 154.92  E-value: 6.60e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRY-TKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15190   13 IPVIYMLVFVLGLSGNGLVLWTVFRSkRKRRRSADTFIANLALADLTFVVTLPLWAVyTALGYHWPFGSFLCKLSSYLVF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGS--IDCTLTFSHPT- 227
Cdd:cd15190   93 VNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTnkVICDMDYSGVVs 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 ----WYWENLLKICVFIFAFIMPVLIITVCYGLmILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVI 303
Cdd:cd15190  173 neseWAWIAGLGLSSTVLGFLLPFLIMLTCYFF-IGRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVKT 251
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 304 IKALVTIPETTFQTVSWHF-------CIALGYTNSCLNPVLYAFLDENF-KRC 348
Cdd:cd15190  252 LYALMYLGILPFSCGFDLFlmnahpyATCLAYVNSCLNPFLYAFFDPRFrQQC 304
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
71-346 7.31e-44

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 153.77  E-value: 7.31e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIvrYTKMKTATN-IYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISI 148
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVA--GLKMKRTVNtIWFLNLAVADLLCCLSLPFSIAHLLLnGHWPYGRFLCKLLPSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFShptw 228
Cdd:cd15115   79 IVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDFL---- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 yweNLLKICVFIFAFIMPVLIITVCYGLMILrlksvRMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIkALV 308
Cdd:cd15115  155 ---VAITITRAVFGFLLPLLIIAACYSFIAF-----RMQRGRFAKSQS--KTFRVIIAVVVAFFVCWAPYHIIGIL-SLY 223
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 309 TIPETTFQTVSW-HFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15115  224 GDPPLSKVLMSWdHLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
71-349 3.24e-43

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 152.43  E-value: 3.24e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDY 150
Cdd:cd15178    1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKG-WIFGTFMCKLVSLLQE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIINVCN--WILSSAIGLPVMFM--ATTKYRQGSIDCTLTFSHP 226
Cdd:cd15178   80 ANFYSGILLLACISVDRYLAI---VHATRALTQKRHLVKFVCAgvWLLSLLLSLPALLNrdAFKPPNSGRTVCYENLGNE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TWY-WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLsgskEKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd15178  157 SADkWRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSF----QKHRAMRVI----FAVVLAFLLCWLPYNVTVLID 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 306 ALV---TIPETTFQ----TVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15178  229 TLMrtkLITETCELrnhvDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
73-349 4.40e-43

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 152.51  E-value: 4.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSV-NYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15392    3 IILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILmAVFCVPFSFIaLLILQYWPFGEFMCPVVNYLQA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPVMFMATTkYRQGSIDCTLTF---SHPT 227
Cdd:cd15392   83 VSVFVSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATALPIAITSRL-FEDSNASCGQYIcteSWPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlSGSKEKDR------NLRRITRMVLVVVAVFIVCWTPIHIY 301
Cdd:cd15392  160 DTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRT-PGEAENNRdqrmaeSKRKLVKMMITVVAIFALCWLPLNIL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 302 VIIKALV-TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15392  239 NLVGDHDeSIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
76-349 1.65e-42

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 151.02  E-value: 1.65e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15393    6 LYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIiGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKAldFRTPRNAKIINVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTFSHPTWY---W 230
Cdd:cd15393   86 VSVFTLTVIAVDRYRAVIHPLKA--RCSKKSAKIIILIIWILALLVALPVaLALRVEELTDKTNNGVKPFCLPVGPsddW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR-----MLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd15393  164 WKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKapgnaQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYNLLN 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 306 ALV-TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15393  244 EIKpEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
71-347 1.89e-42

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 150.68  E-value: 1.89e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVryTKMKTATN-IYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISI 148
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIFITG--FKMKKTVNtVWFLNLAVADFLFTFFLPFSIAYTAMDFhWPFGRFMCKLNSFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ--GSIDCTLTFSHP 226
Cdd:cd15116   79 LFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQnnNKIICFNNFSLS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TWY---WENLLK--------ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAVFIVCW 295
Cdd:cd15116  159 GDNsspEVNQLRnmrhqvmtITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKP--------FKIIAAVIVTFFLCW 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 296 TPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15116  231 APYHILNLLEMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKK 282
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
75-347 4.16e-42

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 149.58  E-value: 4.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRyTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNM 153
Cdd:cd15339    5 SFIGILCSTGLVGNILVLFTIIR-SRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLDTCNQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATT-KYRQGSIDCTLTFSHPT-WYWE 231
Cdd:cd15339   84 FACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKViKFRDGLESCAFNLTSPDdVLWY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKIcvfIFAFIMPVLIITVCYGL-------MILRLKSVRMLSGSKEKDRnLRRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15339  164 TLYQT---ITTFFFPLPLILICYILilcytweMYRKNKKAGRYNTSIPRQR-VMRLTKMVLVLVGVFLVSAAPYHVIQLV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 305 KALVTIPETTFqTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15339  240 NLSVSQPTLAF-YVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
75-349 4.66e-42

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 149.58  E-value: 4.66e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMK---TATNIYIFNLALADALATSTLPFQsVNYLMGT--WPFGTILCKIVISID 149
Cdd:cd15338    5 SVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFL-IHQLLGNgvWHFGETMCTLITALD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTFSHPT- 227
Cdd:cd15338   84 TNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVwMYAGLMPLPDGSVGCALLLPNPEt 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 -WYWENLLKicvFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA 306
Cdd:cd15338  164 dTYWFTLYQ---FFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAHL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 307 LVTIPETTFqTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15338  241 SIDRPSLAF-LYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
70-349 9.06e-42

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 148.92  E-value: 9.06e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  70 AITIMAlYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:cd15207    1 VLFIVS-YSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLvGVFCMPFTLVDNILTGWPFGDVMCKLSPLV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW 228
Cdd:cd15207   80 QGVSVAASVFTLVAIAVDRYRAVVHPTE--PKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKI---CVFIFAFIMPVLIITVCYGLMILRL---KSVRMLSGSKEKD----RNLRRITRMVLVVVAVFIVCWTPI 298
Cdd:cd15207  158 PSDEYRKAyttSLFVLCYVAPLLIIAVLYVRIGYRLwfkPVPGGGSASREAQaavsKKKVRVIKMLIVVVVLFALSWLPL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822324 299 HIYVIIKALVTIPETTFQTV-SWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15207  238 HTVTMLDDFGNLSPNQREVLyVYIYPIAhwLAYFNSCVNPIVYGYFNRNFRKGF 291
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
69-351 1.47e-41

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 149.54  E-value: 1.47e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  69 TAITIMALYSIVCVVGLFGNFLVMYVIvRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:PHA03087  39 NSTILIVVYSTIFFFGLVGNIIVIYVL-TKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW 228
Cdd:PHA03087 118 YYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTM 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsGSKEKDRNLRRItRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:PHA03087 198 NWKLFINFEINIIGMLIPLTILLYCYSKILITLK------GINKSKKNKKAI-KLVLIIVILFVIFWLPFNVSVFVYSLH 270
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 309 TIPETT------FQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE 351
Cdd:PHA03087 271 ILHFKSgckavkYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK 319
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
71-349 3.14e-41

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 147.58  E-value: 3.14e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd14992    1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLmALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKyRQGS------IDCTLTF 223
Cdd:cd14992   81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTE-VLFSvknqekIFCCQIP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 224 SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSvRMLSGSKEKDRNL------RRITRMVLVVVAVFIVCWTP 297
Cdd:cd14992  160 PVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWF-RKVPGFSIKEVERkrlkckRRVIKMLVCVVVLFVICWLP 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 298 IHIYVIIKALVTIPETTFQTVSWH-FCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14992  239 FHLFFLLRDFFPLIMKEKHTLQVYyFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
73-347 4.38e-41

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 146.76  E-value: 4.38e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYN 152
Cdd:cd15180    3 LPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHG-WIFGTGLCKLAGAVFKIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVM-FMATTK-YRQGSIDCTLTFSHPTWYW 230
Cdd:cd15180   82 FYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFiFLEATKdPRQNKTECVHNFPQSDTYW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLksvrmLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 310
Cdd:cd15180  162 WLALRLLYHIVGFLLPLAVMVYCYTSILLRL-----LRSSQGFQK--QRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 311 -------PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15180  235 svldrncGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRR 278
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
74-346 5.15e-41

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 146.80  E-value: 5.15e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYN 152
Cdd:cd15117    4 LVIYSSAFVLGTLGNGLVIWVTG-FRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGfHWPFGWFLCKLYSTLVVFN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY--- 229
Cdd:cd15117   83 LFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFDPWNETaed 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICV----------FIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnlrritRMVLVVVAVFIVCWTPIH 299
Cdd:cd15117  163 PVLWLETVVqrlsaqvitrFVLGFLVPLVIIGGCYGLIAARLWREGWVHSSRPF--------RVLTAVVAAFFLCWFPFH 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 300 IyVIIKALVTIPET-----TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15117  235 L-VSLLELVVILNQkedlnPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFR 285
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
71-347 5.34e-40

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 144.03  E-value: 5.34e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 149
Cdd:cd15159    1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGfDWPFGDWLCRLTALLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCT------LTF 223
Cdd:cd15159   81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCMeypnfeKIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 224 SHPTWywenLLKICVfiFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITrMVLVVVAVFIVCWTPIHIYV 302
Cdd:cd15159  161 RLPLI----LLGACV--IGFGVPVGIILFCYSQITLKLcRTAKENPLTEKSGHHKKACN-VILLVLLVFVVCFSPYHLNI 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 303 I---IKALVTIP----ETTFQtVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15159  234 IqfmIRKLLYQPscseLKAFK-ISLQITVCLMNLNCCLDPFIYFFACKGYKK 284
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
73-349 5.91e-40

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 143.70  E-value: 5.91e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIV--RYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15002    2 VPILLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLlLLFSVPFRAAAYSKGSWPLGWFVCKTADWFG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15002   82 HACMAAKSFTIAVLAKACYMYVVNPTKQVT-IKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLAHE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI---YVI-IK 305
Cdd:cd15002  161 FMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVawlWLIhIK 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 306 ALVTIPETTFQTVSWhfciALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15002  241 SSGSSPPQLFNVLAQ----LLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
75-347 1.60e-39

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 142.50  E-value: 1.60e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 154
Cdd:cd15182    5 VFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQgSIDCTLTFSHPTWYWENLL 234
Cdd:cd15182   84 SSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSD-EDGSLCEYSSIKWKLGYYY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFifaFIMPVLIITVCYGLMILRLKSVRMlsgsKEKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIKALVTIPETT 314
Cdd:cd15182  163 QQNLF---FLIPLGIIVYCYVRILQTLMRTRT----MRKHRTVKLI----FVIVLVFFLSWAPYNIVIFLRSLKDLTIPI 231
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822324 315 FQTVS-----WHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15182  232 CECSKqldyaFYICRNIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
72-346 3.43e-39

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 141.81  E-value: 3.43e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd14999    1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYwE 231
Cdd:cd14999   81 TMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLPTWS-E 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICV---FIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd14999  159 ESYKVYLtllFSTSIVIPGLVIGYLYIRLARKYwLSQAAASNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIWQLLYLY 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 308 VTIPETTFQTVSW-HFCIA-LGYTNSCLNPVLYAFLDENFK 346
Cdd:cd14999  239 SPSLSLSPRTTTYvNYLLTcLTYSNSCINPFLYTLLTKNYK 279
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
71-349 4.92e-39

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 141.50  E-value: 4.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKM-KTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:cd15097    1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADlCFILFCVPFQATIYSLEGWVFGSFLCKAVHFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMfmatTKYRQGSIDcTLTFSHPTW 228
Cdd:cd15097   81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYL----SYYDLIDYA-NSTVCMPGW 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWEN--LLKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd15097  156 EEARrkAMDTCTFAFGYLIPVLVVSLSYTRTIKYLwTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCY 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 306 ALVTIP--ETTFQTVSWHFCIAlgYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15097  236 LYGDFPfnQATYAFRLLSHCMA--YANSCLNPIVYALVSKHFRKGF 279
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
73-347 5.54e-39

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 141.32  E-value: 5.54e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15389    3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLlNTPFTLVRFVNSTWVFGKIMCHLSRFAQYC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKAldfR-TPRNAKIINVCNWILSSAIGLP------VMFMATTKYRQGSIdCTLTFS 224
Cdd:cd15389   83 SVYVSTLTLTAIALDRHRVILHPLKP---RiTPCQGVVVIAIIWIMASCLSLPhaiyqkLVEFEYSNERTRSR-CLPSFP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEK-----DRNLRRITRMVLVVVAVFIVCWTPIH 299
Cdd:cd15389  159 EPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIGDVTTEqyvaqRRKKKKTIKMLMLVVLLFAICWLPLN 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 300 IYVIIkalvtipeTTFQTVSWH-----FCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15389  239 CYHVL--------LSSHPIRSNsalffAFHWLAMSSTCYNPFIYCWLNDSFRS 283
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
73-346 5.96e-39

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 141.43  E-value: 5.96e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYY 151
Cdd:cd15191    3 IPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGyNWLFGSVMCKICGSLLTL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ--GSIDCTLTF-SHPTW 228
Cdd:cd15191   83 NLFASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEelGVNACIMAFpNEKYA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15191  162 QWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNK---QRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALA 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 309 TIPETTFQTVSWH------FCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15191  239 RMGVINNCWVITVidkalpFAICLGFSNSCINPFLYCFVGNHFR 282
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
79-347 4.08e-38

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 139.14  E-value: 4.08e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSI 157
Cdd:cd15189    9 SLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQfNWPFGELLCRVVNGVIKVNLYTSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 158 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY--RQGSIDCTLTFSHPTWYWENLLK 235
Cdd:cd15189   89 YLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAipDLNITACVLLYPHEAWHFAHIVL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICvfIFAFIMPVLIITVCyGLMILRLKSVRMLSGSKEkDRNLRRITRMVLVVVAVFIVCWTPIHIYVI------IKALVT 309
Cdd:cd15189  169 LN--IVGFLLPLLVITFC-NYNILQALRTREESTRCE-DRNDSKATALVLAVTLLFLVCWGPYHFFTFldflfdVGVLDE 244
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822324 310 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15189  245 CFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
77-347 8.54e-38

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 138.35  E-value: 8.54e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFT 155
Cdd:cd15373    7 YGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENdWPFSEALCKIVRFLFYTNLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 235
Cdd:cd15373   87 SILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFDQFVVYS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHI-----YVIIKALVTI 310
Cdd:cd15373  167 SVMLVLLFCVPFVVILVCYALMVRKLLKPSAGTSTNSRSK--KKSVKMIIIVLAVFILCFLPFHVtrtlyYSFRSMDLSC 244
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 311 PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15373  245 GTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRS 281
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
76-348 1.02e-37

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 137.95  E-value: 1.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15158    6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVhKGQWLFGDFLCRISSYALYVNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCtltFSHP--TWYWEN 232
Cdd:cd15158   86 CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKC---FEPPqsNQQLTK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVF--IFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTP------IHIYVII 304
Cdd:cd15158  163 LLVLNYIslVVGFIIPFLVILICYAMIIRTLLKNTMKARKQQSSR--KKAIRMIIIVLLAFLVSFMPyhiqrtIHLHFLS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 305 KALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15158  241 RKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRR 284
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
73-349 1.74e-37

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 137.78  E-value: 1.74e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15927    3 VPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLlLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTF--SHPTWY 229
Cdd:cd15927   83 SIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQIcyPYPQEL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICV---FIFAFIMPVLIITVCYGLMILRL-KSVRML-----SGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI 300
Cdd:cd15927  163 GPNYPKIMVllrFLVYYLIPLLIIGVFYVLMARHLiRSTRNIgsgqnQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHV 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 301 YVIIKALVTIPETTFQTVsWH------FCiaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15927  243 FMLWFHFAPNGLVDYNAF-WHvlkivgFC--LSFINSCVNPVALYLLSGSFRRHF 294
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
74-346 2.73e-37

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 136.80  E-value: 2.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYN 152
Cdd:cd15119    4 IVIYIVAFVLGVPGNAIVIWVTGFKWK-KTVNTLWFLNLAIADFVFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVM-FMATTKYRQGSIDCTLTF----SHPT 227
Cdd:cd15119   83 MFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALyFRDTMELSINVTICFNNFhkhdGDLI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdrnlrrITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15119  163 VMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSK--------FFWTISAVIVAFFVCWTPYHIFSILELS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 308 VTIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15119  235 IHHSSYLHNVLRAGIPLAtsLAFINSCLNPILYVLIGKKFK 275
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
77-346 2.82e-37

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 136.76  E-value: 2.82e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFT 155
Cdd:cd15157    7 YLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGShWVFGDIACRIMSYSLYVNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYrqGSIDCTLTFSHPTWYWENLLK 235
Cdd:cd15157   87 SIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSKGTSKY--NSQTKCLDLHPSKIDKLLILN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSgSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIP---- 311
Cdd:cd15157  165 YIVLVVGFILPFCTLSICYILIIKALLKPRVPQ-SKLRVSH-KKALLTIIITLILFLLCFLPYHILRTVHLMQWSEgqcn 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 550822324 312 ETTFQTVSWHFCIALgyTNSCLNPVLYAFLDENFK 346
Cdd:cd15157  243 LRLHKAVVITLCLAA--ANSCLDPLLYYFAGENFK 275
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
71-347 3.15e-37

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 136.54  E-value: 3.15e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVI-VRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISI 148
Cdd:cd15925    1 ILVALAYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDfHWPFGGAMCKMVLTA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFshPTW 228
Cdd:cd15925   81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKF--PSN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVFIFAFIMPVLIITVCYglmILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15925  159 YWLGAYHLQRVVVAFVVPLGVITTSY---LLLLSFLQQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 309 TIPET-------TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15925  236 KFRAVpwnstfyFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
73-349 4.85e-37

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 136.75  E-value: 4.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15208    3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIIcLPATLLVDVTETWFFGQVLCKIIPYLQTV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIINVCNWILSSAIGLP---VMFMATTKYRQGSIDcTLTFSHPTW 228
Cdd:cd15208   83 SVSVSVLTLSCIALDRWYAICHPLM--FKSTAKRARVSILIIWIVSLLIMIPqaiVMECSRVVPLANKTI-LLTVCDERW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLK---ICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGSKEKD-------------------RNLRRITRMVLV 286
Cdd:cd15208  160 SDSIYQKvyhICFFLVTYLLPLCLMILAY-FQIFRKLWCRQIPGTSSVVqrkwnkprksavaaeekqlRSRRKTAKMLIV 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 287 VVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15208  239 VVIMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFShwLVYANSAINPIIYNFMSGKFREEF 303
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
76-349 1.94e-36

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 134.55  E-value: 1.94e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMF 154
Cdd:cd15921    6 AYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNShWPFGDIACRIILYVLYVNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCtLTFSHPTWYWENLL 234
Cdd:cd15921   86 SSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRC-LELAHDAVDKLLLI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIY--VIIKALVTIPE 312
Cdd:cd15921  165 NYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRPSR--RKACALIIISLGIFLVCFLPYHIVrtIHLITERQIKE 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 313 TTFQTVSWH----FCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15921  243 SCGYILRVRkaavITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
76-347 4.94e-36

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 133.46  E-value: 4.94e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15183    6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY-WENLL 234
Cdd:cd15183   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIrWKRFQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRLksVRMLSGSKEKdrnlrrITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETT 314
Cdd:cd15183  166 ALKLNLLGLILPLLVMIICYTGIINIL--LRRPNEKKAK------AVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTP 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 315 FQTVSWHFCIA------LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15183  238 SCEQSQQLDLAlqvtevIAYTHCCVNPVIYVFVGERFRK 276
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
76-347 5.54e-36

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 133.00  E-value: 5.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSvNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15187    6 LYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQA-YYLLDQWVFGNAMCKIVSGAYYIGFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 235
Cdd:cd15187   85 SMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGNSWKVFTN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTI----- 310
Cdd:cd15187  165 FEVNILGLLIPFSILIFCYHNILRNLR--------RCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLhiidg 236
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822324 311 -PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15187  237 cQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKK 274
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
71-349 6.32e-36

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 133.57  E-value: 6.32e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA------TSTLPFQSVNylmgTWPFGTILCKI 144
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVllvcmpVALVETWARE----PWLLGEFMCKL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 145 VISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY----RQGSIDCT 220
Cdd:cd14997   77 VPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEedfnDGTPVAVC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 221 LTFSHPTwyWENLLKICVFIFAFIMPVLIITVCYGLMILRL------KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVC 294
Cdd:cd14997  157 RTPADTF--WKVAYILSTIVVFFVVPLAILSGLYSVICRRLvghpalESRRADAANRHTLRSRRQVVYMLITVVVLFFVC 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550822324 295 WTPI---HIYVIIKALVTI----PETTFQTVSwhFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14997  235 LLPFrvvTLWIIFAPDEDLqalgLEGYLNLLV--FCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
75-347 9.24e-36

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 132.57  E-value: 9.24e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 154
Cdd:cd15174    5 PLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSG-WVFGTFLCKVVNSMYKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPR--NAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwYWEN 232
Cdd:cd15174   84 SCMLLLTCISVDRYIAIVQATKAHNSKNKRllYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMV------YPSN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 L---LKICVF----IFAFIMPVLIITVCYGLMILRLKSVRmlsgSKEKDRNLRRITRMVLVVVAVFIvcwtPIHIYVIIK 305
Cdd:cd15174  158 EsnrFKVAVLalkvTVGFFLPFVVMVICYTLIIHTLLQAK----RFQKHKALKVIIAVVTVFVLSQL----PYNSILLIK 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 306 ALVTIPETTFQ-TVSWHFCIA------LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15174  230 TINAYNITITDcATSQNLDIAgqvtqsIAFLHSCLNPFLYVFVGVRFRK 278
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
71-349 1.22e-35

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 132.33  E-value: 1.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd14969    1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLmSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGS-IDCTltfshPTW 228
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGgTSCS-----VDW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLK----ICVFIFAFIMPVLIITVCYGLMILRLKSV-------RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTP 297
Cdd:cd14969  155 YSKDPNSlsyiVSLFVFCFFLPLAIIIFCYYKIYRTLRKMskraarrKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTP 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 298 ---IHIYVIIKALVTIPeTTFQTVSWHFcialGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14969  235 yavVSLYVSFGGESTIP-PLLATIPALF----AKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
71-349 1.34e-35

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 132.86  E-value: 1.34e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYL-MGTWPFGTILCKIVISI 148
Cdd:cd14979    1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLIlLVGLPVELYNFWwQYPWAFGDGGCKLYYFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSID--------CT 220
Cdd:cd14979   81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPgpvpdsavCT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 221 LTFSHPTwywENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRML-----------SGSKEKDRNLRRITRMVLVVVA 289
Cdd:cd14979  161 LVVDRST---FKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIkkgtraqgtrnVELSLSQQARRQVVKMLGAVVI 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550822324 290 VFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCI---ALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14979  238 AFFVCWLPFHAQRLMFSYASKEDTFLFDFYQYLYPisgILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
71-349 1.61e-35

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 132.21  E-value: 1.61e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIvRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID 149
Cdd:cd15120    1 VLIAVALFVTFLVGLVVNGLYLWVL-GFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNhWAFGTVLCKVLNSTL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVM-FMATTKYRQGSIDCTLTF----- 223
Cdd:cd15120   80 SVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLaFRETRLDEKGKTICQNNYalstn 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 224 --------SHPTWYWenLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAVFIVCW 295
Cdd:cd15120  160 wesaevqaSRQWIHV--AMFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKP--------FKVMFTAVVSFFVCW 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822324 296 TPIHIYVIIKALVTIPETTFQtVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15120  230 LPYHLHSGLVLTRGRPPSLTD-ITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
71-347 2.17e-35

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 131.80  E-value: 2.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID 149
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNnWIFGEALCRLVTVAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTkYRQGSIDCTLTFSHPTW- 228
Cdd:cd15162   81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQT-IFLPALDITTCHDVLPEq 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 ----YWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15162  160 llvgDWFYYF-LSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKKKKRAI----KLAATVLAIFIICFAPSNLLLLA 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 305 KALVTIPETTFQTV-SWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15162  235 HYSLISSSGTGHLYfAYLLALCLSTLNSCIDPFIYYFVSKEFRD 278
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
71-347 3.45e-35

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 131.56  E-value: 3.45e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVI-VRYTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISI 148
Cdd:cd15926    1 IIISIVYSVVCALGLVGNLLVLYLMkSKQGWKKSSINLFVTSLAVTDFQFVLTLPFWAVeNALDFTWLFGKAMCKIVSYV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTF---SH 225
Cdd:cd15926   81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFpdnRG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWENLLKICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTP---IHIYV 302
Cdd:cd15926  161 NAQFWLGLYHAQKVLLGFLIPLGIISLCY-LLLVRFITDKNITGSSTKRRS--KVTKSVTIVVLSFFLCWLPnqaLTTWG 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 303 IIKALVTIPETT--FQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15926  238 ILIKLNVVHFSYeyFTTQVYIFPITvcLAHSNSCLNPILYCLMRREFRK 286
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
71-347 5.44e-35

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 130.64  E-value: 5.44e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNY-LMGTWPFGTILCKIVISID 149
Cdd:cd15193    1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTaLGGQWLFGEGLCKLSSFII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVchpVKALD---FRTPRNAKIINVCNWILSSAIGLPVMFmattkYR--QGSIDCTLTFS 224
Cdd:cd15193   81 AVNRCSSILFLTGMSVDRYLAV---VKLLDsrpLRTRRCALITCCIIWAVSLVLGIPSLV-----YRnlINESVCVEDSS 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWENLLKICVfifAFIMPVLIITVCYGLMILRLKsvRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTP------I 298
Cdd:cd15193  153 SRFFQGISLATLFL---TFVLPLIVILFCYCSILVRLR--RHFHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPfntlkaV 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 299 HIYVIIKALVtIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15193  228 RLLLELGGGV-LPCHTTVAIRQGLTITacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
76-347 1.04e-34

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 129.95  E-value: 1.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15185    6 LYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY-WENLL 234
Cdd:cd15185   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDsWKRFH 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRLksvrMLSGSKEKDRNLRRITRMVLVVVAVfivcWTPIHIYVIIKALVTIPETT 314
Cdd:cd15185  166 ALRMNIFGLALPLLIMVICYTGIIKTL----LRCPSKKKYKAIRLIFVIMVVFFIF----WTPYNLVLLLSAFQSIFFET 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 315 FQTVSWHFCIA------LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15185  238 DCERSKHLDLAmqvtevIAYTHCCINPVIYAFVGERFRK 276
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
76-347 1.46e-34

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 129.49  E-value: 1.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSvNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15184    6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWA-HYAANEWVFGNAMCKLLTGLYHIGFFS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW-YWENLL 234
Cdd:cd15184   85 GIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQYqFWKNFQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgsKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIkalvtipeTT 314
Cdd:cd15184  165 TLKMNILGLVLPLLVMIICYSGILKTLLRCR-----NEKKRH--KAVRLIFTIMIVYFLFWAPYNIVLLL--------NT 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 315 FQT--------------VSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15184  230 FQEffglnncsssnrldQAMQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
80-346 3.84e-34

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 128.38  E-value: 3.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  80 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSIF 158
Cdd:cd15380   10 ICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQfNWPFGNFLCRVISGVIKANLFISIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 159 TLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY--RQGSIDCTLTFSHPTWYWENLLKI 236
Cdd:cd15380   90 LVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHvpDLNISACILLFPHEAWHFARRVEL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 237 CvfIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETT-- 314
Cdd:cd15380  170 N--IVGFLLPLAAIVFFNFHIIASLRERTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVIQgc 247
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 550822324 315 ----FQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15380  248 fweeFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
71-347 4.21e-34

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 127.91  E-value: 4.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISID 149
Cdd:cd15114    1 VVALVLYAVVFLVGVPGNALVAWVTGFEAK-RSVNAVWFLNLAVADLLCCLSLPILAVPIAQdGHWPFGAAACKLLPSLI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP-VMFMAT-TKYRQGSIDCTLTFSHPT 227
Cdd:cd15114   80 LLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPsFIYRRIhQEHFPEKTVCVVDYGGST 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYwENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGskekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15114  160 GV-EWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKS--------RRTLKVVTAVVVGFFLCWTPYHVVGLIIAA 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 308 VTIPETTFQTV--SWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15114  231 SAPNSRLLANAlkADPLTVSLAYINSCLNPIIYVVAGRGFRK 272
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
71-349 5.28e-34

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 127.46  E-value: 5.28e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15059    1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADiLVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMatTKYRQGSID----CTLtfSH 225
Cdd:cd15059   81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFG--WKDEQPWHGaepqCEL--SD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYwenLLKICvfIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKDrnlRRITRMVLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd15059  157 DPGY---VLFSS--IGSFYIPLLIMIIVY---------ARIYRAAKRKE---RRFTLVLGVVMGAFVLCWLPFFFTYPLV 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 306 ALVT---IPETTFQtvswhFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15059  220 VVCKtcgVPELLFK-----FFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
76-343 6.37e-34

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 128.05  E-value: 6.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15156    6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATT--KYRQGSIDCTLTFSHPTWYwENL 233
Cdd:cd15156   86 SILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTnnQLNNNSETCFENFSSKTWK-TYL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFI--FAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIP 311
Cdd:cd15156  165 SKIVIFIeiVGFFIPLILNVTCSTMVLKTLRRPNTLSRSK---LNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTQ 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 312 -------ETTFQTV-SWHFCIALgyTNSCLNPVLYAFLDE 343
Cdd:cd15156  242 tfkncsvVAAVRTMyPITLCIAV--SNCCFDPIVYYFTSE 279
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
72-349 9.06e-34

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 127.12  E-value: 9.06e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15206    2 LIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLlAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNA-KIINVCnWILSSAIGLPVMFMATTKY--RQGSIDCTLTFshPT 227
Cdd:cd15206   82 VSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAyKVIAGI-WLLSFLIMSPILVFSNLIPmsRPGGHKCREVW--PN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgskekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15206  159 EIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLLEAK------------KRVIRMLFVIVVEFFICWTPLYVINTWKAF 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 308 vtIPETTFQTVSW---HFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15206  227 --DPPSAARYVSSttiSLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
79-347 1.25e-33

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 127.19  E-value: 1.25e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSI 157
Cdd:cd15381    9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 158 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKIC 237
Cdd:cd15381   89 YFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLDYPSEGWHVALNIL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 238 VFIFAFIMPVLIITVCYGLMILRLKSVRMlsgSKEKD-RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT---IPET 313
Cdd:cd15381  169 LNVVGFLIPLSIITFCSTQIIQVLRNNKM---QKFKEiQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKlglISGC 245
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 314 TFQTV---SWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15381  246 RWEDIldiGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
73-349 1.31e-33

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 126.32  E-value: 1.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMG-TWPFGTILCKIVISIDY 150
Cdd:cd15067    2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSiVMPFSILHEMTGgYWLFGRDWCDVWHSFDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP--VMFMATTKYRQGSIDCTLTfSHPTW 228
Cdd:cd15067   82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPaiAWWRAVDPGPSPPNQCLFT-DDSGY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YwenLLKICVfifAFIMPVLIITVCYGlMILRlksvrmlSGSKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL- 307
Cdd:cd15067  161 L---IFSSCV---SFYIPLVVMLFTYY-RIYR-------AAAKE-----QKAAKTLGIVMGVFILCWLPFFVTNILIGFc 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 308 ----VTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15067  222 psncVSNPDILFPLVTW-----LGYINSGMNPIIYACSSRDFRRAF 262
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
75-349 1.69e-33

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 126.57  E-value: 1.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15155    5 AVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYwENLL 234
Cdd:cd15155   85 GSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWK-TYLS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFI--FAFIMPVLIITVCYGLMILRLKSVRMLSgskEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE 312
Cdd:cd15155  164 KITIFIevVGFIIPLLLNLTCSSLVLRTLRKPATLS---QIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQA 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 313 TT------FQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15155  241 IAncgverFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
77-347 1.75e-33

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 126.81  E-value: 1.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFT 155
Cdd:cd15968    7 YSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDrWLFGDFMCRLVRFLFYFNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY---RQGSIDCTLTFSHPTWYwen 232
Cdd:cd15968   87 SILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIirnRTVCYDLAPPALFPHYV--- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMILRLksVRMLSGSKEKDRNLRRIT-RMVLVVVAVFIVCWTPIH----IYVIIKAL 307
Cdd:cd15968  164 PYGMALTVSGFLLPFSIILWCYCLVVRTL--CRTLGPAEPPAQARRRKSiRTIVTVTLLFALCFLPFHitrtIYLAVRVT 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 308 VTIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15968  242 PGVPCHVLEAVAACYKITrpLASANSVLNPLLYFLTKKKFGR 283
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
75-349 1.99e-33

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 126.64  E-value: 1.99e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15390    5 IVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLiSAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPVMFMATT--KYRQGSIDCTLTF----SHPT 227
Cdd:cd15390   85 AASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQLLYSTTetYYYYTGSERTVCFiawpDGPN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSK----EKDRNLRRITRMVLVVVAVFIVCWTPIHIYVI 303
Cdd:cd15390  163 SLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTprqlESVRAKRKVVKMMIVVVVIFAICWLPYHLYFI 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 304 IKALVtipettFQTVSWHF-------CIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15390  243 LTYLY------PDINSWKYiqqiylaIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
71-349 3.06e-33

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 126.29  E-value: 3.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMG-TWPFGTILCKIVISI 148
Cdd:cd15134    1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLlILGLPFELYTIWQQyPWVFGEVFCKLRAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT-PRNAKIInVCNWILSSAIGLPVMFMATTKYRQ----------GSI 217
Cdd:cd15134   81 SEMSSYASVLTITAFSVERYLAICHPLRSHTMSKlSRAIRII-IAIWIIAFVCALPFAIQTRIVYLEypptsgealeESA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 218 DCtlTFSHPTWYWENLLKICVFIFaFIMPVLIITVCYGLMILRLKS---VRMLSGSKEKDRN----LRRITRMVLVVVAV 290
Cdd:cd15134  160 FC--AMLNEIPPITPVFQLSTFLF-FIIPMIAIIVLYVLIGLQLRRstlLRRGQRSVSGGRRssqsRRTVLRMLVAVVVA 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 291 FIVCWTPIH----IYVIIKALVTIPETTFQTVswhFCIA--LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15134  237 FFICWAPFHaqrlLTVYAKNMTPPYLFINRIL---FYISgvLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
77-346 9.48e-33

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 124.44  E-value: 9.48e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFT 155
Cdd:cd15161    7 YILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNhWPFGEVPCRLAGFLFYLNMYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwYWEN--- 232
Cdd:cd15161   87 SLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQL------YREKasr 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 --LLKICVfifAFIMPVLIITVCYGLMILRLKsvrmlSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI----YVIIKA 306
Cdd:cd15161  161 gaLVSLAV---AFTIPFVTTVTCYLLIIRSLR-----TGKREEKPLKDKAIKMIILVLTIFLICFVPYHIsryiYILSHN 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 307 LVTIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15161  233 GAGASCSSRRGLALanRITSCLTCLNGALDPVMYFFVAEKFR 274
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
73-346 1.33e-32

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 124.52  E-value: 1.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15928    3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRlWRYRPWRFGDLLCRLMYFFSET 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd15928   83 CTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFA--FIMPVLIITVCYGLMILRLKSVRMLS---GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA 306
Cdd:cd15928  163 GLLSVMLWVSTsfFFVPMVCLSLLYGLIGRALWDRRQRSrtaGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVGRVIFN 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 307 LVTIPETTFQTVSWHFCI---ALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15928  243 HSRASTKHLHYVSQYFNLvsfVLFYLSAAINPILYNLMSKRYR 285
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
76-345 1.46e-32

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 124.14  E-value: 1.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYViVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMF 154
Cdd:cd15118    6 LHGIVSTLGIVENLLILWV-VGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGhTWELGTTFCRIHSSIFFLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFS--------- 224
Cdd:cd15118   85 VSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPyFVFRDVIERKDGRKLCYYNFAlfspspdnn 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTW-YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgskekDRNLRRITRMVLVVVAVFIVCWTPIHIYVI 303
Cdd:cd15118  165 HPICkQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRC--------RRRPGRFVRLVVSVVVSFALCWAPYHIFSI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 304 IKALVTIPETTFQTV--SWHFCIALGYTNSCLNPVLYAFLDENF 345
Cdd:cd15118  237 IEVMAHNQHSLRPLViqGLPFATTLAFLNSVLNPVLYVFSCPDF 280
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
61-349 2.25e-32

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 123.11  E-value: 2.25e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  61 PTGSPSMITAITIMALYSIvcvvglFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGT 139
Cdd:cd15321    3 VQATAAIAAAITFLILFTI------FGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILvATLIIPFSLANELMGYWYFRK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 140 ILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGL-PVMFMATTKYRQGSI- 217
Cdd:cd15321   77 TWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLpPLIYKGKQKDEQGGLp 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 218 DCTLtfSHPTWYWenllkICVFIFAFIMPVLIitvcyglMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTP 297
Cdd:cd15321  157 QCKL--NEEAWYI-----LSSSIGSFFAPCLI-------MILVYLRIYLIAKNREK-----RFTFVLAVVIGVFVLCWFP 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 298 IHIYVIIKALVT----IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15321  218 FFFSYSLGAICPelckVPHSLFQFFFW-----IGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
75-346 2.62e-32

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 123.36  E-value: 2.62e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYT-KMKTATNIYIFNLALADALATSTLPFQSVnYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15188    5 VFYTLVFLLGLAGNLLLFVVLLLYVpKKKKMTEVYLLNLAVSDLLFLVTLPFWAM-YVAWHWVFGSFLCKFVSTLYTINF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVM-FMATTKYRQGSIDCTLTFSHPTWYWEN 232
Cdd:cd15188   84 YSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMvFVQTHHTNNGVWVCHADYGGHHTIWKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE 312
Cdd:cd15188  164 VFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRP--------PGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 313 TTFQTVSWHFCIALGYTNS------CLNPVLYAFLDENFK 346
Cdd:cd15188  236 IGNCERSRHLDYALQVTESlafvhcCLNPLLYAFVSKRFR 275
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
72-349 2.96e-32

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 122.47  E-value: 2.96e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLvGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPtwyw 230
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYYTYDKG---- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 enlLKICVFIFAFIMPVLIITVCYglmiLRLKSVRMlsgsKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALV-- 308
Cdd:cd15061  157 ---YRIYSSMGSFFLPLLLMLFVY----LRIFRVIA----KE-----RKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCdc 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 309 TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15061  221 QFSEALSTAFTW-----LGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
77-347 3.32e-32

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 122.93  E-value: 3.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15181    7 YSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLNFYCS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP-VMFMATTKYRQGSI-DCTLTFSH-PTWYWENL 233
Cdd:cd15181   86 SLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPnLVFLEVETSTNANRtSCSFHQYGiHESNWWLT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGLMILRLksvRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIpET 313
Cdd:cd15181  166 SRFLYHVVGFFLPLLIMGYCYATIVVTL---CQSSRRLQK----QKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDL-KA 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 314 TFQTVSWH--------FCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15181  238 VVKNCKLNdlldaaitVTESLGFSHCCLNPILYAFIGVKFRN 279
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
71-349 6.31e-32

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 121.67  E-value: 6.31e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15064    1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLvAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfSHPTWy 229
Cdd:cd15064   81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECLIS-QDIGY- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenllKICVFIFAFIMPVLIITVCYGlMILRlksvrmlSGSKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL-- 307
Cdd:cd15064  159 -----TIFSTFGAFYIPLLLMLILYW-KIYR-------AAARE-----RKAAKTLGIILGAFIVCWLPFFLVALIVPLcs 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 308 -VTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15064  221 hCWIPLALKSFFLW-----LGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
76-347 9.48e-32

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 121.72  E-value: 9.48e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMF 154
Cdd:cd15160    6 VYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHhNWTFGPLSCKVVGFFFYTNIY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILssAIGLPVMFMATTKYRQGSIDCTLTFSH---PTWY-W 230
Cdd:cd15160   86 ASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVL--ELGTHSVFLGHDELFRDEPNHTLCYEKypmEGWQaS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVfifAFIMPVLIITVCYgLMILRlkSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKA---L 307
Cdd:cd15160  164 YNYARFLV---GFLIPLSLILFFY-RRVLR--AVRQSPSLEREEK--RKIIGLLLSIVVIFLLCFLPYHVVLLVRSvieL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 308 VTIPETTFQT---VSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15160  236 VQNGLCGFEKrvfTAYQISLCLTSLNCVADPILYIFVTEDVRQ 278
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
76-349 1.80e-31

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 120.65  E-value: 1.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15173    6 MYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHE-WIFGTVMCKITNGLYTINLYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRN--AKIINVCNWILSSAIGLPvMFMATTKYRQGSIDCTLTFshPTWYWENL 233
Cdd:cd15173   85 SMLILTCITVDRFIVIVQATKAHNCHAKKMrwGKVVCTLVWVISLLLSLP-QFIYSEVRNLSSKICSMVY--PPDAIEVV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGLMILRLksvrMLSGSKEKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIKALVTIPET 313
Cdd:cd15173  162 VNIIQMTVGFFLPLLAMIICYSVIIKTL----LHAKGFQKHKSLKII----FVVVAVFILTQLPYNIMKLIRTLHIENTD 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 314 tfqTVSWHFCI----ALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15173  234 ---STNFKYAIliteAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
71-349 2.13e-31

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 120.43  E-value: 2.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15323    1 AGLAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILvATLVMPFSLANELMGYWYFGQVWCNIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMfMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15323   81 VLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPL-ISMYRDPEGDVYPQCKLNDETWY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenLLKICvfIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKDrnlRRITRMVLVVVAVFIVCWTPI----HIYVIIK 305
Cdd:cd15323  160 ---ILSSC--IGSFFAPCLIMILVY---------IRIYRVAKARE---KRFTFVLAVVMGVFVVCWFPFffsySLYGICR 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 306 ALVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15323  223 EACEVPEPLFKFFFW-----IGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
77-347 3.11e-31

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 120.68  E-value: 3.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15374    7 YGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYAdHNHWPFGVVACKIVRFLFYANLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 235
Cdd:cd15374   87 SILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPEEFDHYVHYS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTF 315
Cdd:cd15374  167 SAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARLLKADC 246
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 316 QT-----VSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15374  247 DTlniinVTYKVTRPLASANSCLDPILYFLAGDKYRR 283
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
71-346 3.31e-31

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 120.26  E-value: 3.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDY 150
Cdd:cd15179    1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN-WYFGNFLCKAVHVIYT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY- 229
Cdd:cd15179   80 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFEl 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMILRLksvrmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15179  160 WVVAFRFQHILVGLVLPGLVILTCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFML 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 310 IPETTF-----QTVSWHFCI--ALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15179  232 LEIIKQscemeQTVHKWISIteALAFFHCCLNPILYAFLGAKFK 275
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
76-347 6.47e-31

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 119.58  E-value: 6.47e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLP-FQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15194    6 LYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPlWVDKEVVLGPWRSGSFLCKGSSYIISVNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTwywENLL 234
Cdd:cd15194   86 CSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPS---KVIF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGskEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVI------IKALV 308
Cdd:cd15194  163 SLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQKSG--KHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKAlaiasgLQVEV 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 309 TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15194  241 TCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRR 279
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
73-346 1.06e-30

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 118.70  E-value: 1.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATnIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYY 151
Cdd:cd15372    3 VPSLYTLVFLVGLPANGLALWVLATQVKRLPST-IFLINLAVADLLLILVLPFKISYHFLGNnWPFGEGLCRVVTAFFYG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTkYRQGSIDCT-----LTFSHP 226
Cdd:cd15372   82 NMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQS-YPLERLNITlchdvLPLDEQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TWYWENLLkICVFIFAFIMPVLIITVCYGLMIlrlksvRMLSGSKEKDRNLRRITRMvlvVVAVFIVCWTPIHIYVIIKA 306
Cdd:cd15372  161 DTYLFYYF-ACLAVLGFLLPLVVILFCYGSVL------HTLLRSGQRYGHAMKLTVL---VLVSFVLCFTPSNLLLLLHY 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 307 LVTIPETTFQTVSWHF-CIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15372  231 SDPTLDDGGNLYIVYMvSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
75-346 1.10e-30

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 119.10  E-value: 1.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYlMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15175    5 AMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASA-AKKWVFGEEMCKAVYCLYKMSFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRtPRN---AKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWe 231
Cdd:cd15175   84 SGMLLLMCISIDRYFAIVQAASAHRHR-SRAvfiSKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTNNKQTLS- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFIMPVLIITVCYGLMILRLksvrMLSGSKEKDRNLRRITRMVLVVVAVFIvcwtPIHIYVIIKALVTIP 311
Cdd:cd15175  162 VKIQISQMVLGFLVPLVVMSFCYSVIIKTL----LQARNFEKNKAIKVIIAVVVVFVVFQL----PYNSVMLVSTLSSFK 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 312 ETTFQ-TVSWHFCIALGYTNS------CLNPVLYAFLDENFK 346
Cdd:cd15175  234 GNTTDcDYSKNLDFALDVTYSlacfrcCLNPFLYAFIGVKFR 275
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
71-349 1.23e-30

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 118.14  E-value: 1.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15329    1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLvALLVMPLAIIYELSGYWPFGEILCDVWISFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYrqgSIDCTLTFSHPTWY 229
Cdd:cd15329   81 VLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKV---NDPGVCQVSQDFGY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenllKICVFIFAFIMPVLIITVCYGlmilrlksvRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALV- 308
Cdd:cd15329  158 -----QIYATFGAFYIPLIVMLVLYY---------KIYRAAKSE----RKAIKTLGIIMGAFTLCWLPFFILALLRPFLk 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 309 -----TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15329  220 pikcsCIPLWLSRLFLW-----LGYANSFLNPIIYAKFNREFRTPF 260
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
76-349 1.40e-30

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 118.70  E-value: 1.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYlMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15172    6 IYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYE-AHQWIFGNFSCKLLRGIYAINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNA--KIINVCNWILSSAIGLPVmFMATTKYRQGSIDCTL-TFSHPTWYWEN 232
Cdd:cd15172   85 GMLLLACISVDRYIAIVQATKSFRLRSRTLAysKLICAAVWLLAILISLPT-FIFSEVYDFGLEEQYVcEPKYPKNSTAI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFI----FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15172  164 MWKLLVLSlqvsLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKA--------VRVVVAVVLVFLVCQVPYNIVLLIEAIN 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 309 TIPETTFQT---VSWHFCI--ALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15172  236 LGEQQSCSSekaVAYAKTIteCLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
75-347 1.47e-30

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 118.72  E-value: 1.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 154
Cdd:cd15177    5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQG-WIFGNAMCKLIQGLYAINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFR--TPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW-E 231
Cdd:cd15177   84 SGFLFLTCISVDRYVVIVRATSAHRLRpkTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSRTvK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgSKEKDRNLRRITRMVLVVVAVFivcwTPIHIYVIIKALVTIP 311
Cdd:cd15177  164 GATALTQVVLGFAIPLIVMAVCYAAIGRTLLAAR----GWERHRALRVIAALVVAFVLFQ----LPYSVVLLLDTADLLA 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 312 ETTFQTVSW---HFCI----ALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15177  236 TLELSCSQSkrkDIALlvtsGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
77-347 1.92e-30

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 118.32  E-value: 1.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd16001    7 YSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMrDRWPFGDFLCKLVRFLFYTNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 235
Cdd:cd16001   87 SILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYDLTSPDNFGNYFPYG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIH----IYVIIKALVTIP 311
Cdd:cd16001  167 MVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAAR--AKSIRTILLVCGLFALCFVPFHitrtIYLFVRVYLVQD 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 312 ETTFQTVS-----WHFCIALgytNSCLNPVLYAFLDENFKR 347
Cdd:cd16001  245 CPLLQFVSlaykiWRPLVSF---NSCINPLLYFLSGDSNRL 282
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
68-340 2.27e-30

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 117.97  E-value: 2.27e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  68 ITAITIMalySIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVIS 147
Cdd:cd14975    1 VLGCTLL---SLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCtlTFSHPT 227
Cdd:cd14975   78 VCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMC--KYRHYS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGskekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd14975  156 DGQLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRR--------RRTGRLIASVVVAFAACWLPYHVGNLLEVV 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 308 VTIPETTFQTVSW--------HFCIALGYTNSCLNPVLYAF 340
Cdd:cd14975  228 SELIGGSKMAGTLgkvaeagrPIAGALAFLSSSINPLLYAF 268
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
71-349 3.12e-30

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 118.34  E-value: 3.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15205    1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITfFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTK------YRQGSIDCTLTF 223
Cdd:cd15205   81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEvkydflYEKRHVCCLERW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 224 SHPTwyWENLLKICVFIFAFIMPVLIITVCYGLMILRL---------KSVRMLSGSKEKD--RNLRRITRMVLVVVAVFI 292
Cdd:cd15205  161 YSPT--QQKIYTTFILVILFLLPLTTMLFLYSRIGYELwikkrvgdaSVLQTIHGIEMSKisRKKKRAVKMMVTVVLLFA 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550822324 293 VCWTPIHIYVIIKALvTIPETTFQTVSWHFCIA----LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15205  239 VCWAPFHVVHMMIEY-SNLENKYDGVTIKLIFAivqlIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
75-347 8.07e-30

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 116.93  E-value: 8.07e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 153
Cdd:cd15377    5 AVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQG-SIDCTLTFSHPTWYWEN 232
Cdd:cd15377   85 YGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNkTITCYDTTSDEYLRSYF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGlMILRLKSVRMLSGSKEKDRNLRRIT-RMVLVVVAVFIVCWTPIHiyvIIKALVTIP 311
Cdd:cd15377  165 IYSMCTTVAMFCVPFILILGCYG-LIVRALIYKDMKYTEENNAPLRRKSiYLVIIVLTVFAVSYLPFH---VMKTLNLRA 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 312 ETTFQT-----------VSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15377  241 RLDFQTpamcafndrvyATYQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
75-349 1.13e-29

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 116.02  E-value: 1.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15923    5 AIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFK-MHSYRRESAGLQKLCNFVLSLYYINMY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAttkyrqGSIDCTLTFSHPTWYWENLL 234
Cdd:cd15923   84 VSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLD------SSNEKTMCFQRTKQTESLKV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV--TIPE 312
Cdd:cd15923  158 FLLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVGSRSE---TKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVgkSYSC 234
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 313 TTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15923  235 DSKLIIHFflQSAFCLSDMNCCLDAFCYYFATKEFREAY 273
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
76-346 2.09e-29

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 115.69  E-value: 2.09e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15391    6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDlIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPVMFMATTK----YRQGSIDCTLTFSHPTwYW 230
Cdd:cd15391   86 ASVLTNTAIGIDRFFAVIFPLRSR--HTKSRTKCIIASIWAISFSLSSVQLFAGRTQrygqYSEGRVLCGESWPGPD-TS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSvRMLSGSKEKDRNL------RRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15391  163 RSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWN-RTAPGNADKGRDDmqikskRKVIKMLVFVVLMFGICWLPLHLFNLV 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 305 KALVTI----PETTFQTVsWHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15391  242 QDFSTVfrnmPQHTTRLI-YGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
71-347 2.12e-29

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 115.64  E-value: 2.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID 149
Cdd:cd15368    1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNhWIFGKPLCNVVTVLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTkYRQGSIDCTLTFSHPTW- 228
Cdd:cd15368   81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLT-YYVKELNITTCFDVLKWt 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 ------YWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYV 302
Cdd:cd15368  160 mlpniaAWAAFL-FTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQK----RRAIYLALIVLLVFITCFAPNNFIL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 303 IIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15368  235 LAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRK 279
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
75-346 2.19e-29

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 115.56  E-value: 2.19e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 153
Cdd:cd15967    5 PVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRkWIFGQVFCKITRFCFNLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMatTKYRQGSIDCTLTFSHPtwYWENL 233
Cdd:cd15967   85 YGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFF--SKTNSNGTKCFDTTFND--YLESY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LK--ICVFIFAFIMPVLIITVCYGLMILrlksvrMLSGSKEKDRNLR-RITRMVLVVVAVFIVCWTPIHIYVIIKALVTI 310
Cdd:cd15967  161 LTysLGWTVTGFVIPLLIILGCYGHVVV------VLCRNNNVDKGLKqRCLKLVIILIVLFSVCYIPYHVFRNLNLLSRI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 311 PETTFQTVSWHFCIALGYT--------NSCLNPVLYAFLDENFK 346
Cdd:cd15967  235 LQKQGSCTQWFRGIYIAHQvsrglvclNSALNPLVYLMGSEDIL 278
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
71-347 2.31e-29

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 114.67  E-value: 2.31e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15210    1 YFAAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFnLPLAASTFLHQAWIHGETLCRVFPLLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15210   81 YGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPKVCSCSILRDKKG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENllKICVFIFAFIMPVLIITVCYGLmilrlksvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15210  161 RSP--KTFLFVFGFVLPCLVIIICYAR------------------REDRRLTRMMLVIFLCFLVCYLPITLVNVFDDEVA 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 IPettfqtvsWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15210  221 PP--------VLHIIAyvLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
71-349 6.31e-29

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 114.02  E-value: 6.31e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA--LATSTLPFQSVNYL-MGTWPFGTILCKIVIS 147
Cdd:cd14995    1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLmvLVAAGLPNEIESLLgPDSWIYGYAGCLLITY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATT--KYRQGSIDCTLTFSH 225
Cdd:cd14995   81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLsiKHYGDDIVVRCGYKV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWENLLKICVFIFaFIMPVLIITVCYGLMilrlksVRMLSGSKekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd14995  161 SRHYYLPIYLADFVLF-YVIPLLLAIVLYGLI------GRILFSSR------KQVTKMLAVVVVLFALLWMPYRTLVVYN 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 306 ALVTIPETTfqtvSWH--FCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14995  228 SFASPPYLD----LWFllFCRTCIYLNSAINPILYNLMSQKFRAAF 269
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
73-346 7.12e-29

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 117.04  E-value: 7.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMyVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLmGTWPFGTILCKiVISIDYY- 151
Cdd:PHA02638 101 IKIFYIIIFILGLFGNAAII-MILFCKKIKTITDIYIFNLAISDLIFVIDFPFIIYNEF-DQWIFGDFMCK-VISASYYi 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFM---ATTKYRQGSIDCTLTFSHPTW 228
Cdd:PHA02638 178 GFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIfeaSNIIFSAQDSNETISNYQCTL 257
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWEN----------LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlrriTRMVLVVVAVFIVCWTPI 298
Cdd:PHA02638 258 IEDNeknnisflgrILQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKS--------IIIVSIIIICSLICWIPL 329
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 299 HIYVIIKALVTIpETTFQTVSWHFC--IALGY----------TNSCLNPVLYAFLDENFK 346
Cdd:PHA02638 330 NIVILFATMYSF-KGFNSIISEHICgfIKLGYammlaeaislTHCCINPLIYTLIGENFR 388
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
78-349 7.98e-29

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 113.29  E-value: 7.98e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  78 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15050    8 STISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIvGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPV----MFMATTKYRQGSIDCTLTFSHPTWYwen 232
Cdd:cd15050   88 IFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPIlgwhHFARGGERVVLEDKCETDFHDVTWF--- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 llKICVFIFAFIMPVLIITVCYGLMIlrlksvrmlsgsKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVtipE 312
Cdd:cd15050  165 --KVLTAILNFYIPSLLMLWFYAKIF------------KAVNRE-RKAAKQLGFIMAAFILCWIPYFILFMVIAFC---K 226
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 313 TTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15050  227 NCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
76-349 8.71e-29

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 113.21  E-value: 8.71e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYNM 153
Cdd:cd15053    6 FLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLvAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVMCS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF-MATTKYRqgsidctltfshptwywen 232
Cdd:cd15053   86 TASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFgLNNVPYR------------------- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVF----------IFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEkdrnlRRITRMVLVVVAVFIVCWTP---IH 299
Cdd:cd15053  147 DPEECRFynpdfiiyssISSFYIPCIVMLLLYYRIFRALR--------RE-----KKATKTLAIVLGVFLFCWLPfftLN 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 300 I-----YVIIKALVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15053  214 IlnaicPKLQNQSCHVGPALFSLTTW-----LGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
82-349 8.92e-29

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 113.45  E-value: 8.92e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTL 160
Cdd:cd15326   12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 161 CTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwyWENLLKICVFI 240
Cdd:cd15326   92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEIT-------EEPFYALFSSL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 241 FAFIMPVLIITVCY-GLMILRLKsvrmLSGSKEKDRNLRRITRMvlvvvavFIVCWTPIHIYVIIKAL---VTIPETTFQ 316
Cdd:cd15326  165 GSFYIPLIVILVMYcRVYIVALK----FSREKKAAKTLGIVVGM-------FILCWLPFFIALPLGSLfshLKPPETLFK 233
                        250       260       270
                 ....*....|....*....|....*....|...
gi 550822324 317 TVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15326  234 IIFW-----LGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
72-346 1.19e-28

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 113.31  E-value: 1.19e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDY 150
Cdd:cd14987    2 TLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVqHNQWPMGEFTCKITHLIFS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP-VMFMAT-TKYRQGSIDCTLTF-SHPT 227
Cdd:cd14987   82 INLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPdTYFLKTvTSPSNNETYCRSFYpEESF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMilrlksVRMLSGSKEKDRNLRRitRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd14987  162 KEWLIGMELVSIVLGFVIPFPIIAVFYFLL------ARAISASSDQERKSSR--KIIFSYVVVFLVCWLPYHTVVLLDIL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 308 VT---IPET----TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd14987  234 SFlhlIPFScqleNFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
75-340 2.72e-28

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 112.55  E-value: 2.72e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 153
Cdd:cd15369    5 SVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNdWLFGEAMCRVVTAAFYCNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY--RQGSIDC--TLTFSHPTWY 229
Cdd:cd15369   85 YCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQipDLGITTChdVLNEQLLMGY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFaFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHIYVIIK--AL 307
Cdd:cd15369  165 YVYYFSIFSCLF-FFVPLIITTVCYVSIIRCLSSSSDVANSSKKTRAL----FMAVAVFCVFVICFGPTNVLLLAHyvRF 239
                        250       260       270
                 ....*....|....*....|....*....|...
gi 550822324 308 VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 340
Cdd:cd15369  240 AYTSTNDASYFAYLLCVCVGSISCCLDPLIYYY 272
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
76-349 6.18e-28

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 111.44  E-value: 6.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15979    6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDlMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY-----RQGSIDCTLTFSHP--- 226
Cdd:cd15979   86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPvpvgdRPRGHQCRHAWPSAqvr 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 -TWYwenllkICVFIFAFIMPVLIITVCYGLMilrlksvrmlsgSKEKDRNL---RRITRMVLVVVAVFIVCWTPIHIYV 302
Cdd:cd15979  166 qAWY------VLLLLILFFIPGVVMIVAYGLI------------SRELYRGLlakKRVIRMLVVIVAMFFLCWLPIFSAN 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 550822324 303 IIKALVtiPETTFQTVSW---HFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15979  228 TWRAFD--PLSAHRALSGapiSFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
71-349 6.80e-28

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 111.66  E-value: 6.80e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLlGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMF-MATTKYRQGSIDctltfsHPT 227
Cdd:cd15051   81 VMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSfLPIHLgWNTPDGRVQNGD------TPN 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 ---WYWENLLKICVFIFAFIMPVLIITVCYgLMIL--------RLKSVRMLSGSKEKDRNL----RRITRMVLVVVAVFI 292
Cdd:cd15051  155 qcrFELNPPYVLLVAIGTFYLPLLIMCGVY-LRIFriareqakRINALTPASTANSSKSAAtareHKATVTLAAVLGAFI 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 550822324 293 VCWTPIHIYVIIKALV--TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15051  234 ICWFPYFTYFTYRGLCgdNINETALSVVLW-----LGYANSALNPILYAFLNRDFRRAF 287
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
82-345 9.07e-28

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 110.89  E-value: 9.07e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMgTWPFGTILCKIVISIDYYNMFTSIFTLC 161
Cdd:cd15165   12 VLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKK-QWPLGRTLCSFLESLYFVNMYGSILIIV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 162 TMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKyrQGSIDCTLTFSHPTwyWENLLKICVFIF 241
Cdd:cd15165   91 CISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKP--TNNTRCFHGFSNKT--WSKKVIVVVEEF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 242 AFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRItrmVLVVVAVFIVCWTPIHI----YVIIKALVTIPETTFQT 317
Cdd:cd15165  167 GFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKSVKI---VLSNLVVFLVCFTPYHLgiflQFLVKNDIINDCSTKQS 243
                        250       260       270
                 ....*....|....*....|....*....|
gi 550822324 318 VSW--HFCIALGYTNSCLNPVLYAFLDENF 345
Cdd:cd15165  244 IRLfvQVSMCLANVNCCLDAICYYFILKEF 273
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
73-346 2.33e-27

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 109.83  E-value: 2.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFqSVNYLM--GTWPFGTILCKIVISID 149
Cdd:cd15394    3 IIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPL-TLAYAFepRGWVFGRFMCYFVFLMQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPVmfMATTKYrqgsIDCT-LTFSHPTW 228
Cdd:cd15394   82 PVTVYVSVFTLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPA--AAHTYY----VEFKgLDFSICEE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YW-----ENLLKICVFIF-AFIMPVLIITVCYGLMILRLKSvRMLSGS-----KEKDRNLRRIT-RMVLVVVAVFIVCWT 296
Cdd:cd15394  154 FWfgqekQRLAYACSTLLiTYVLPLLAISLSYLRISVKLRN-RVVPGSmtqsqAEWDRARRRKTfRLLVVVVVAFAICWL 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 297 PIHIYVIIKALVT--IPETTFQTVSWhFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15394  233 PLHIFNVIRDIDIdlIDKQYFNLIQL-LCHWLAMSSACYNPFLYAWLHDSFR 283
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
71-349 2.40e-27

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 109.26  E-value: 2.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15322    1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILvATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDcTLTFSHPTWY 229
Cdd:cd15322   81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGP-ICKINDEKWY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenllKICVFIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKDrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALV- 308
Cdd:cd15322  160 -----IISSCIGSFFAPCLIMVLVY---------IRIYQIAKNRE---KRFTFVLAVVIGVFVICWFPFFFTYTLTAVCd 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 309 -TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15322  223 cSVPETLFKFFFW-----FGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
71-344 3.33e-27

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 109.67  E-value: 3.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM--GTWPFGTILCKIVIS 147
Cdd:cd15204    1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLvAVFCLPFEMDYYVVrqRSWTHGDVLCAVVNY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPV-MFMATTKY-RQGSIDCTLTFS- 224
Cdd:cd15204   81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPR--MKRRTACVVIALVWVVSLLLAIPSaVYSKTTPYaNQGKIFCGQIWPv 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWENLLkICVFIFAFIMPVLIITVCYgLMILRLKSVRMLSGS-----KEKDRNLRRITRMVLVVVAVFIVCWTPIH 299
Cdd:cd15204  159 DQQAYYKAYY-LFLFVLEFVLPVLIMTLCY-LRIVRKVWFRRVPGQqteqiRRRLRRRRRKVRLLVVILTAFVLCWAPYY 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 300 IYVIIK-------ALVTIPETTFQTVSwhfCIALGytNSCLNPVLYAFLDEN 344
Cdd:cd15204  237 GYAIVRdffptllSKEKLNTTIFYIVE---ALAMS--NSMINTVVYVAFNNN 283
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
76-349 3.90e-27

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 109.57  E-value: 3.90e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQsVNYLMGTWP--FGTILCKIVISIDYYN 152
Cdd:cd15357    6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVlLFGMPLE-VYEMWSNYPflFGPVGCYFKTALFETV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP--------VMFMATTKYRQGSIDCTLTfs 224
Cdd:cd15357   85 CFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPntsihgikLQYFPNGTLIPDSATCTVV-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWENLLKICVFIFaFIMPVLIITVCYGLMILRLKSVRMLSgSKEKDRNLRR-----ITRMVLVVVAVFIVCWTPIH 299
Cdd:cd15357  163 KPLWIYNLIIQITSLLF-YVLPMGVISVLYYLMGLKLRGDKSLE-ADEMNVNIQRpsrksVTKMLFVLVLVFAICWAPFH 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 300 IYVIIKALVTIPETTFQTVSWHFCIALG---YTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15357  241 VDRLFFSFVVEWTEPLANVFNLIHVVSGvffYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
71-349 3.93e-27

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 108.83  E-value: 3.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfSHPTWY 229
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETICQIT-EEPGYA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKicvfifAFIMPVLIITVCYGLMIlrlksVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKAL-- 307
Cdd:cd15325  160 LFSALG------SFYLPLAIILVMYCRVY-----VVALKFSREK-----KAAKTLGIVVGCFVLCWLPFFLVMPIGSIfp 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 308 -VTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15325  224 aYKPSDTVFKITFW-----LGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
70-349 6.77e-27

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 109.06  E-value: 6.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  70 AITIMALYSIVcVVGLFGNFLVMYVIVRYTKMK-TATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTiLCKIVIS 147
Cdd:cd15057    1 IITGCILYLLV-LLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLvAILVMPWAAVNEVAGYWPFGS-FCDVWVS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMfmaTTKYRQGSIDCTLTFSHP 226
Cdd:cd15057   79 FDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfIPVQ---LGWHRADDTSEALALYAD 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 ---------TWYwenllKICVFIFAFIMPVLIITVCYGLM-------ILRLKSV-RMLSGSKEKDRNLR-------RITR 282
Cdd:cd15057  156 pcqcdsslnRTY-----AISSSLISFYIPVAIMIVTYTRIyriarrqIRRIAALeRAAQESTNPDSSLRsslrretKALK 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 283 MVLVVVAVFIVCWTPIHIYVII--------KALVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFlDENFKRCF 349
Cdd:cd15057  231 TLSIIMGVFVCCWLPFFILNCVlpfcdlrtAQFPCVPDTTFIVFVW-----LGWANSSLNPIIYAF-NADFRKAF 299
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
71-349 7.19e-27

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 108.41  E-value: 7.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTL-PFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15055    1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVmPFSMIRSIETCWYFGDTFCKLHSSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAI-GLPVMFMATTKYRQGSI----DCTLTFS 224
Cdd:cd15055   81 YILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYsSVLLYDNLNQPGLIRYNscygECVVVVN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWywenllkICVFIFAFIMPVLIITVCYG-LMILRLKSVRMLSGSKEKDRNLRRITRMVL-----------VVVAVFI 292
Cdd:cd15055  161 FIWG-------VVDLVLTFILPCTVMIVLYMrIFVVARSQARAIRSHTAQVSLEGSSKKVSKkserkaaktlgIVVGVFL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 550822324 293 VCWTPIHIYVIIKALVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15055  234 LCWLPYYIVSLVDPYISTPSSVFDVLIW-----LGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
77-349 1.04e-26

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 108.31  E-value: 1.04e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15154    7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFM---ATTKYRQGSID-CTLTFShpTWYWEN 232
Cdd:cd15154   87 CLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVhssSDCLLHGEKVYrCFESFS--DNDWKG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVF--IFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlRRITRMVLVVVAVFIVCWTP----IHIYVIIKA 306
Cdd:cd15154  165 LLPLVVLaeILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRR-----RKTVRLLLVNLVIFLICFVPynttLAVYGLLRA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 307 -LVTIPETTFQTVS--WHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15154  240 nLVEDTWNIKDTLRkvLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
70-349 1.09e-26

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 107.41  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  70 AITIMALYSIVCVVGlfGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:cd15049    2 LICIATGSLSLVTVG--GNILVILSFRVNRQLRTVNNYFLLSLACADLIiGLVSMNLYTVYLVMGYWPLGPLLCDLWLAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATT--KYRQGSID-CTLTF-S 224
Cdd:cd15049   80 DYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQYfvGERTVPDGqCYIQFlD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTwywenlLKICVFIFAFIMPVLIITVCYGLMilrlksvrmlsgSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15049  160 DPA------ITFGTAIAAFYLPVLVMTILYWRI------------YRETARE-RKAARTLSAILLAFIITWTPYNILVLV 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 305 KALVT--IPETtfqtvSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15049  221 STFCAkcIPDT-----LWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
71-351 1.13e-26

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 108.10  E-value: 1.13e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15314    1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGlVMPPSMVRSVETCWYFGDLFCKIHSSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFM---ATTKYRQGSI---DCTLTF 223
Cdd:cd15314   81 ITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLelnIKGIYYNHVAcegGCLVFF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 224 SHPTwywenllKICVFIFAFIMPVLIITVCYG-LMILRLKSVRMLSGSKEKDRNL-----RRITRMVLVVVAVFIVCWTP 297
Cdd:cd15314  161 SKVS-------SVVGSVFSFYIPAVIMLCIYLkIFLVAQRQARSIQSARTKSGASsskmeRKATKTLAIVMGVFLLCWTP 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 298 IHIYVIIKALV--TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFldenFKRCFRE 351
Cdd:cd15314  234 FFLCNIIDPFInySIPPVLIEVLNW-----LGYSNSTLNPFIYAF----FYSWFRK 280
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
75-346 1.42e-26

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 107.52  E-value: 1.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGTILCKIVISIDYYNMF 154
Cdd:cd15176    5 VFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNG-WVLGTAMCKITSALYTMNFS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVchpVKALDF-RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPT-WYWEN 232
Cdd:cd15176   84 CGMQFLACISVDRYVAI---TKATSRqFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLvTSAKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMilrlksVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE 312
Cdd:cd15176  161 TIQILEVLLGFVLPFLVMVFCYSRV------ARALSRTPNVKK--SRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 313 -TTFQTVSWHFCIALGYTNS------CLNPVLYAFLDENFK 346
Cdd:cd15176  233 lITDCSMSKTLDIAIQVTESialfhsCLNPVLYVFMGASFK 273
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
75-349 2.26e-26

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 107.08  E-value: 2.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVryTKMK--TATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYY 151
Cdd:cd15375    5 VMYSIIFIVGFPGNIIAIFVYL--FKMRpwKSSTIIMLNLALTDLLYVTSLPFLIYYYINGeSWIFGEFMCKFIRFIFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCT-LTFSHP--TW 228
Cdd:cd15375   83 NLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLdFTSSDNlnTI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLkicVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRnlrritRMVLVVVAVFIVCWTPIHIYVIIK-- 305
Cdd:cd15375  163 WWYNWI---LTVLGFLLPLVIVTLCYTRIIYTLaKGPHTGSASKQKAR------RLIILILLVFYVCFLPFHILRVVRie 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 306 -ALVTIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15375  234 tRLPPVSCCLKHQVHAIYIITrpLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
71-349 2.60e-26

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 106.36  E-value: 2.60e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADlAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVM---------FMATTKyrqgsidCT 220
Cdd:cd15060   81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLigwndwpenFTETTP-------CT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 221 LTFshptwywENLLKICVFIFAFIMPVLIITVCYgLMILRlksvrmlSGSKEkdrnlRRITRMVLVVVAVFIVCWTPIHI 300
Cdd:cd15060  154 LTE-------EKGYVIYSSSGSFFIPLLIMTIVY-VKIFI-------ATSKE-----RRAARTLGIIMGVFVVCWLPFFL 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 301 YVIIKALVTIPETTFQTVSwhFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15060  214 MYVILPFCETCSPSAKVVN--FITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
79-349 3.78e-26

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 106.24  E-value: 3.78e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15052    9 LLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLvGLLVMPLSILTELFGGvWPLPLVLCLLWVTLDVLFCTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRTPRNA--KIINVcnWILSSAIGLPVMFMattkyrqGSIDCTLTFSHPTWYWEN-L 233
Cdd:cd15052   89 IMHLCTISLDRYMAIRYPLRTRRNKSRTTVflKIAIV--WLISIGISSPIPVL-------GIIDTTNVLNNGTCVLFNpN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGLmilrlkSVRMLsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL-----V 308
Cdd:cd15052  160 FVIYGSIVAFFIPLLIMVVTYAL------TIRLL-------SNEQKASKVLGIVFAVFVICWCPFFITNILTGLceecnC 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 309 TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15052  227 RISPWLLSVFVW-----LGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
72-349 8.47e-26

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 105.77  E-value: 8.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15123    2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKaldfRTPRNAKIIN----VCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSH 225
Cdd:cd15123   82 TSVGVSVFTLTVLSADRYRAIVKPLE----LQTSDAVLKTcckaGCVWIVSMLFAIPeAVFSDLYSFRDPEKNTTFEACA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWENLLK-----ICVFIFaFIMPVLIITVCYGLMILRL-KSVRML-----SGSKEKDRNLRRITRMVLVVVAVFIVC 294
Cdd:cd15123  158 PYPVSEKILQeihslLCFLVF-YIIPLSIISVYYFLIARTLyKSTFNMpaeehSHARKQIESRKRVAKTVLVLVALFAFC 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 550822324 295 WTPIHIYVIIKALV---TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15123  237 WLPNHILYLYRSFTyhtSVDSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
73-368 9.92e-26

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 106.14  E-value: 9.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTaTNIYIFNLALADALATSTLPFQSVNYLmGTWPFGTILCKIVISIDYYN 152
Cdd:PHA02834  31 VIVFYILLFIFGLIGNVLVIAVLIVKRFMFV-VDVYLFNIAMSDLMLVFSFPFIIHNDL-NEWIFGEFMCKLVLGVYFVG 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKaLDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWEN 232
Cdd:PHA02834 109 FFSNMFFVTLISIDRYILVVNATK-IKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWSA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgskekDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT--- 309
Cdd:PHA02834 188 FFNFEINIFGIVIPLIILIYCYSKILYTLKNCK--------NKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSvgl 259
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550822324 310 --IPETTFQTV--SWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRI 368
Cdd:PHA02834 260 idIGCYHFKKIvySIDIAELISFVHCCVNPIIYAFVGKNFKKVFKNMFCRTNNIFIRQSSNNV 322
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
73-349 1.07e-25

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 105.69  E-value: 1.07e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSV----NYlmgTWPFGTILCKIVIS 147
Cdd:cd15133    3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYelwqNY---PFLLGSGGCYFKTF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH-- 225
Cdd:cd15133   80 LFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGVPASAQCTVrk 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWENLLKICVFIFaFIMPVLIITVCYGLMILRLKSVRMLS-------------GSKEKDRNLRRITRMVLVVVAVFI 292
Cdd:cd15133  160 PQAIYNMIPQHTGHLF-FVLPMAVISVLYLLMALRLARERGLDatgagskigtrtgQLLQHPRTRAQVTKMLFILVVVFA 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 293 VCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALG---YTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15133  239 ICWAPFHIDRLMWSFISDWTDNLHEVFQYVHIISGvffYLSSAVNPILYNLMSTRFREMF 298
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
74-340 1.28e-25

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 104.90  E-value: 1.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15121    4 IAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIdcTLTF-SHPTWYWEN 232
Cdd:cd15121   84 YASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINM--KLCIpYHPSVGHEA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlsgskekdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK---ALVT 309
Cdd:cd15121  162 FQYLFETITGFLLPFTAIVTCYSTIGRRLRSARF--------RRKRRTNRLVVLIIATFALFWLPYHVVNLIQvagALQN 233
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 550822324 310 IPETTF----QTVSWHFCIALGYTNSCLNPVLYAF 340
Cdd:cd15121  234 QAGNASvlkaAKLARPNVTALAFLSSSVNPVLYAF 268
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
69-347 1.33e-25

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 104.99  E-value: 1.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  69 TAITIMALYSIVcvVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVIS 147
Cdd:cd15402    1 TALACILIFTIV--VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADlVVAIYPYPLVLTSIFHNGWNLGYLHCQISGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPT 227
Cdd:cd15402   79 LMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYwenllKICVFIFAFIMPVLIITVCY----GLMILRLKSVRMLSGSKEKDRNLRRITRMvLVVVAVFIVCWTPIHIyvI 303
Cdd:cd15402  159 AY-----TIAVVFFHFILPIIIVTFCYlriwILVIQVRRRVKPDNKPKLKPHDFRNFVTM-FVVFVLFAVCWAPLNF--I 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 304 IKALVTIPETTFQTV-SWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15402  231 GLAVAVDPETIVPRIpEWLFVASyyMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
73-348 1.53e-25

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 104.83  E-value: 1.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQS-VNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15012    2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNlSIYLIPSWPFGEVLCRMYQFVHSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd15012   82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDREM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKI---CVFIFAFIMPVLIITVCYGLMilrlkSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15012  162 FNSKLydtINFIVWYLIPLLIMTVLYSKI-----SIVLWKSSSIEAR--RKVVRLLVAVVVSFALCNLPYHARKMWQYWS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 309 --TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15012  235 epYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
71-347 1.57e-25

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 105.21  E-value: 1.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15397    1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILvCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDfrTPRNAKIINVCNWILSSAIGLPvmFMATT-----KYRQGSIDCTLTFS 224
Cdd:cd15397   81 CMSVTVSILSLVLIALERHQLIINPTGWKP--SVSQAYLAVVVIWMLACFISLP--FLAFHiltdePYKNLSHFFAPLAD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 H----PTWYWENLLKI---CVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDR---NLRRITRMVLVVVAVFIV 293
Cdd:cd15397  157 KavctESWPSEHHKLAyttWLLLFQYCLPLLFILVCYLRIYLRLrRRKDMLERRGEYNRragHSKRINVMLVSLVAAFAL 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 294 CWTPIHIY-VIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15397  237 CWLPLNVFnAIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
76-347 1.68e-25

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 105.02  E-value: 1.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRyTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMgtWPFGTILCKIVISIDYYNMF 154
Cdd:cd14978    6 VLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDiLVLLSALPLFLLPYIA--DYSSSFLSYFYAYFLPYIYP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 -------TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPT 227
Cdd:cd14978   83 lantfqtASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 ------WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLK--------SVRMLSGSKEKDRNLRRITRMVLVVVAVFIV 293
Cdd:cd14978  163 llrqneTYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRkskkrrrlLRRRRRLLSRSQRRERRTTIMLIAVVIVFLI 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 294 CWTPIHIYVIIKALVTIPET--TFQTVSwHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd14978  243 CNLPAGILNILEAIFGESFLspIYQLLG-DISNLLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
71-349 1.79e-25

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 104.11  E-value: 1.79e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTvLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwy 229
Cdd:cd15062   81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGVN------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMIlrlksVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15062  154 EEPGYVLFSSLGSFYLPLAIILVMYCRVY-----VVAFKFSREK-----KAAKTLGIVVGAFVLCWFPFFVVLPLGSLFS 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 310 ---IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15062  224 tlkPPEPVFKVVFW-----LGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
71-349 1.87e-25

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 105.08  E-value: 1.87e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15048    1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLvGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFmATTKYRQGSI----DCTLTFsH 225
Cdd:cd15048   81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAII-GWDLWTGYSIvptgDCEVEF-F 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWenllKICVFIFAFIMPVLIITVCYGLMIL---------RLKSVRMLSGSKEKDRNL-----------RRITRMVL 285
Cdd:cd15048  159 DHFYF----TFITSVLEFFIPFISVSFFNLLIYLnirkrsrrrPLRSVPILPASQNPSRARsqreqvklrrdRKAAKSLA 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550822324 286 VVVAVFIVCWTPIHIYVIIKALVTipETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15048  235 ILVLVFLICWAPYTILTIIRSFCS--GSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
68-340 2.20e-25

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 104.50  E-value: 2.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  68 ITAITIMALYSIVcvvGLFGNFLVMYVIV--RYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIV 145
Cdd:cd15122    1 ATGTIFLLLAALL---GLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 146 ISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH 225
Cdd:cd15122   78 YYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPCH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTwyweNLLKICVFIF----AFIMPVLIITVCYGLMILRLKSVRMLSGSkekdrnlrRITRMVLVVVAVFIVCWTPIHIY 301
Cdd:cd15122  158 AS----RGHAIFHYTFetlvAFVLPFGVILFSYSVILVRLKGARFRRRA--------RVEKLIAAIVVAFALLWVPYHVV 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 302 VIIKALVTIPETTFQTVSWHF-------CIALGYTNSCLNPVLYAF 340
Cdd:cd15122  226 NLLQVVANLAPGEVLEKLGGAakaaragATALAFFSSSVNPLLYVF 271
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
76-347 2.74e-25

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 104.14  E-value: 2.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSvNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15186    6 FYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWT-HYLINEWGLHNAMCKLTTAFFFIGFFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPvMFMATtkyRQGSIDCTLTFSHPTW-YWENLL 234
Cdd:cd15186   85 GIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVP-QFMFT---KMKENECLGDYPEVLQeIWPVLR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRLKSVrmlsgskeKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL----VTI 310
Cdd:cd15186  161 NVELNFLGFLLPLLIMSYCYFRIIQTLFSC--------KNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLklydFFP 232
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 311 PETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15186  233 SCDMKKDLRLalSVTETIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
71-349 2.79e-25

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 104.43  E-value: 2.79e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd14977    1 YVIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLLTKDWLFGDVMCKLVPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTK----YRQGSID-CTLTFS 224
Cdd:cd14977   81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVAressLDNSSLTvCIMKPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 ------HPTW--YWenllkicVFIFAFIMPVLIITVCYGLM--ILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVC 294
Cdd:cd14977  161 tpfaetYPKArsWW-------LFGCYFCLPLAFTAVCYLLMarTLIRAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFC 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 550822324 295 WTPIHIYVIIKAL----VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14977  234 WLPEHISNILRATlyneVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
73-349 3.39e-25

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 104.36  E-value: 3.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15065    2 IGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLvALLVMTFAVVNDLLGYWLFGETFCNIWISFDVM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFS-HPTWY 229
Cdd:cd15065   82 CSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISfLPIHLGWHRLSQDEIKGLNHASNpKPSCA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVF--IFAFIMPVLIITVCYGLMIL-------RLKSVRMLSGSKEKDRNLRRITRMVLVVVA----------- 289
Cdd:cd15065  162 LDLNPTYAVVssLISFYIPCLVMLLIYSRLYLyarkhvvNIKSQKLPSESGSKFQVPSLSSKHNNQGVSdhkaavtlgii 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550822324 290 --VFIVCWTPIHIYVIIKAL--VTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15065  242 mgVFLICWLPFFIINIIAAFckTCIPPKCFKILTW-----LGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-349 3.66e-25

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 103.86  E-value: 3.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAlatSTLPFQS-VNY---LMGTWPFGTILCKIVISIDYYN 152
Cdd:cd16003    7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDA---SMAAFNTlINFiyaLHSEWYFGEAYCRFHNFFPITS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKaldfrtPR----NAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFshPTW 228
Cdd:cd16003   84 VFASIYSMTAIAVDRYMAIIDPLK------PRlsatATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAW--PGG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLL-KICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKD----RNLRRITRMVLVVVAVFIVCWTPIHIYVI 303
Cdd:cd16003  156 PDQHFTyHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYheqlRAKRKVVKMMIIVVLTFAICWLPYHIYFI 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 304 IKALV------TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd16003  236 VTGLYqqlnrwKYIQQVYLASFW-----LAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
75-346 5.99e-25

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 103.33  E-value: 5.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15153    5 TTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTpRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDC--TLTFSHPTWYWEN 232
Cdd:cd15153   85 ASICFLTCISIQRCFFLLHPFKARDWKR-RYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCfaDLGMKKLNFGAAI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRM-LSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHI-----YVIIKA 306
Cdd:cd15153  164 AMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKqQQSTSEKQKAL----RMVRMCAAVFFICFAPYHInflfyLMVSES 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 307 LVTIPETTFQTVSWH-FCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15153  240 IITNCEVSQVILQFHpISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-349 7.15e-25

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 103.02  E-value: 7.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAlatSTLPFQSV-NYLMGT---WPFGTILCKIVISIDYYN 152
Cdd:cd16002    7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEA---SMSAFNTViNFTYAIhneWYYGLEYCKFHNFFPIAA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKAldfRTPRNAKIINVCN-WILSSAIGLPVMFMATTKYRQGSIDCTLTF-SHPTWYW 230
Cdd:cd16002   84 VFASIYSMTAIALDRYMAIIHPLQP---RLSATATKVVICViWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWpEHEERKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSK----EKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA 306
Cdd:cd16002  161 ETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSdryhEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQY 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 307 LVtiPETTFQTVSWHFCIA---LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd16002  241 FH--PELYEQKFIQQVYLAimwLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
82-346 7.20e-25

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 103.43  E-value: 7.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWPFGTILCKIVISIDYYNMFTSIFTL 160
Cdd:cd15131   12 VVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRlWQYRPWNFGDLLCKLFQFVSESCTYSTILNI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 161 CTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW--ENLLKICV 238
Cdd:cd15131   92 TALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAvrSGLLTIMV 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 239 FIFA--FIMPVLIITVCYGLM---ILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPET 313
Cdd:cd15131  172 WVSSvfFFLPVFCLTVLYSLIgrkLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEAGS 251
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 314 TFQTVSWHFC----IALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15131  252 LEIALISQYCnlvsFVLFYLSAAINPILYNIMSKKYR 288
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
84-349 9.94e-25

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 101.98  E-value: 9.94e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  84 GLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCT 162
Cdd:cd15330   14 AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVlVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 163 MSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF-MATTKYRQGSIDCTLTFSHPTWYWENLlkicvfiF 241
Cdd:cd15330   94 IALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLgWRTPEDRSDPDACTISKDPGYTIYSTF-------G 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 242 AFIMPVLIITVCYGlmilrlksvRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVII----KALVTIPETTFQT 317
Cdd:cd15330  167 AFYIPLILMLVLYG---------RIFKAAARE----RKTVKTLGIIMGTFILCWLPFFIVALVlpfcESTCHMPELLGAI 233
                        250       260       270
                 ....*....|....*....|....*....|..
gi 550822324 318 VSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15330  234 INW-----LGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
76-349 1.13e-24

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 102.26  E-value: 1.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15978    6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDlMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAT----TKYRQGSID-CTLTF----SH 225
Cdd:cd15978   86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNlvpfTRINNSTGNmCRLLWpndvTQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYwenllkICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKekdrnlrRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15978  166 QSWY------IFLLLILFLIPGIVMMTAYGLISLELyRGIKFLMAKK-------RVIRMLIVIVILFFLCWTPIFSANAW 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 305 KALVTI-PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15978  233 RAFDTRsADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
71-349 1.31e-24

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 101.87  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15324    1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILvATLVIPFSLANEVMGYWYFGSTWCAFYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQgsidCTLTfsHPTWY 229
Cdd:cd15324   81 VLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEWE----CLLN--DETWY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenLLKICvfIFAFIMPVLIITVCYgLMILRLKSVRMlsgskekdrnlRRITRMVLVVVAVFIVCWTPI----HIYVIIK 305
Cdd:cd15324  155 ---ILSSC--TVSFFAPGLIMILVY-CKIYRVAKMRE-----------KRFTFVLAVVMGVFVLCWFPFfftySLHAVCR 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 306 ALVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15324  218 KRCGIPDALFNLFFW-----IGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
77-349 1.66e-24

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 101.76  E-value: 1.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15367    7 YILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHdNWTYSELLCKICGILLYENIYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWIlsSAIGLPVMFMATTKYRQGSIDCTLTFSH-PTWYWENLL 234
Cdd:cd15367   87 SIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWL--KELMTCVFFFLHGEISKDKENHSVCFEHyPIKAWEHNI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMilrLKSVRMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETT 314
Cdd:cd15367  165 NYYRFYAGFLFPIFLLSFSYCRI---LRAVRKSHGTQKSQKI--QIKRLVLSTVVIFLVCFGPYHILLLVRSVFERDCNF 239
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 315 FQTV--SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15367  240 AEGIfnYYHFSLLLTSFNCVADPVLYCFASESTYHDF 276
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
78-349 2.29e-24

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 101.14  E-value: 2.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  78 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15327    8 AIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLlSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwyWENLLKI 236
Cdd:cd15327   88 ILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPDESICSIT-------EEPGYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 237 CVFIFAFIMPVLIITVCYglmiLRLKSVrMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKAL---VTIPET 313
Cdd:cd15327  161 FSSLFSFYLPLMVILVMY----FRVYVV-ALKFSREK-----KAAKTLAIVVGVFILCWFPFFFVLPLGSFfpaLKPSEM 230
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 550822324 314 TFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15327  231 VFKVIFW-----LGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
71-349 2.96e-24

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 101.03  E-value: 2.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVgLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15063    2 ISLLVLTFLNVLV-VLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLvGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTkyRQGSIDCTLTFSHPTWY 229
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWND--GKDGIMDYSGSSSLPCT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFA----FIMPVLIITVCYGlmilrlKSVRMLSGSKEKDRNLRRITRMvlvvvavFIVCWTPIHIYVIIK 305
Cdd:cd15063  159 CELTNGRGYVIYSalgsFYIPMLVMLFFYF------RIYRAARMETKAAKTVAIIVGC-------FIFCWLPFFTVYLVR 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 306 ALVT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15063  226 AFCEdcIPPLLFSVFFW-----LGYCNSALNPCIYALFSRDFRFAF 266
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
78-346 3.54e-24

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 101.30  E-value: 3.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  78 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd14986    8 GVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADlVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI-DCTLTFSHPtWYWEnLLK 235
Cdd:cd14986   88 TYILVSMSLDRYQAIVKPMSSLKPR--KRARLMIVVAWVLSFLFSIPQLVIFVERELGDGVhQCWSSFYTP-WQRK-VYI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFAFIMPVLIITVCYGLMI------LRLKSVRMLSGSKEKDRNLR--------------RITRMVLVVVAVFIVCW 295
Cdd:cd14986  164 TWLATYVFVIPLIILSYCYGRILrtiwirSRQKTDRPIAPTAMSCRSVScvssrvslisrakiKTIKMTLVIILAFILCW 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 296 TPIHIYVIIKALVTIPETTFQTVSWHFCIALgyTNSCLNPVLYAFLDENFK 346
Cdd:cd14986  244 TPYFIVQLLDVYAGMQQLENDAYVVSETLAS--LNSALNPLIYGFFSSHLS 292
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
81-346 8.02e-24

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 100.21  E-value: 8.02e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  81 CVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSIFT 159
Cdd:cd14991   11 FVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGeHWIFGEAWCRVNLFMLSVNRSASIAF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 160 LCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVF 239
Cdd:cd14991   91 LTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIRWHNALF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 240 IFAFIMPVLIITVCyglmILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIY----VIIKALVTIPETTF 315
Cdd:cd14991  171 LLEFFLPLGLIVFC----SVRIACNLRIRQSLGKQARVQRAIRLVFLVVIVFVLCFLPSIIAgllaLVFKNLGSCRCLNS 246
                        250       260       270
                 ....*....|....*....|....*....|.
gi 550822324 316 QTVSWHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd14991  247 VAQLFHISLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
74-349 9.59e-24

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 100.16  E-value: 9.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSV-NYLMgTWPFGTILCKIVISIDYY 151
Cdd:cd15195    4 VLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADlMVTFFNMPMDAVwNYTV-EWLAGDLMCRVMMFLKQF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIINVCNWILSSAIGLP--VMFMATTK-YRQGSIDCTLTFSHPTW 228
Cdd:cd15195   83 GMYLSSFMLVVIALDRVFAILSPLSANQAR--KRVKIMLTVAWVLSALCSIPqsFIFSVLRKmPEQPGFHQCVDFGSAPT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YW-ENLLKICVFIFAFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNLRRITR-------MVLVVVAVFIVCWT 296
Cdd:cd15195  161 KKqERLYYFFTMILSFVIPLIITVTCYLLILFeiskMAKRARDTPISNRRRSRTNSLERarmrtlrMTALIVLTFIVCWG 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 297 PIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15195  241 PYYVLGLWYWFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
73-349 1.03e-23

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 99.79  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYY 151
Cdd:cd15922    3 IPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLGsHWPFGQFLCQLKVFLLST 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd15922   83 HMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELSLLY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFIMPVLIITVCYGLM---ILRLKSvRMLSGSKEKDRNLRRITrmvlVVVAVFIVCWTPIHIY----VII 304
Cdd:cd15922  163 FVWNFVLLILGFLLPFGVSLTCYALLgasIAKMNS-NNARGRAMKAKSLQMIG----ISLVIFIICFVPLHVTrtvgVVV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 305 KALVTIPETTFQTV--SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15922  238 KLFYPESCTLLHKVevAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
75-338 1.09e-23

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 100.22  E-value: 1.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15058    5 LLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADlVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMFMATTKYRQGSIDCtltFSHPTwywen 232
Cdd:cd15058   85 TASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPIMNQWWRANDPEANDC---YQDPT----- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 llkICVF-----------IFAFIMPVLIITVCYG---------LMILRLKSVRMLSGSKE--------KDRNLRRITRMV 284
Cdd:cd15058  157 ---CCDFrtnmayaiassVVSFYIPLLIMIFVYArvfliatrqLQLIDKRRLRFQSECPApqttspegKRSSGRRPSRLT 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550822324 285 LV-----------VVAVFIVCWTPIHIYVIIKALVT--IPETTFQTVSWhfciaLGYTNSCLNPVLY 338
Cdd:cd15058  234 VVkehkalktlgiIMGTFTLCWLPFFIANIINVFNRnlPPGEVFLLLNW-----LGYINSGLNPIIY 295
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
79-349 1.21e-23

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 99.83  E-value: 1.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVG----LFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15317    5 IVLVLAmlitVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLlGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI--------DCTLTFSH 225
Cdd:cd15317   85 TTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLEEYsseiscvgGCQLLFNK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 pTWYWENLLkicvfifAFIMPVLIITVCYG-LMILRLKSVRMLSG------------SKEKDRNLRRITRMVLVVVAVFI 292
Cdd:cd15317  165 -IWVLLDFL-------TFFIPCLIMIGLYAkIFLVARRQARKIQNmedkfrsseensSKASASRERKAAKTLAIVMGIFL 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 550822324 293 VCWTPIHIYVIIKAL--VTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15317  237 FCWLPYFIDTIVDEYsnFITPAIVFDAVIW-----LGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
79-347 1.21e-23

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 99.47  E-value: 1.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSI 157
Cdd:cd15209    9 VTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVvAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 158 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYwenllKIC 237
Cdd:cd15209   89 FNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTVSTVY-----TIT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 238 VFIFAFIMPVLIITVCY----GLMILRLKSVRMLSGSKEKDRNLRRITRMvLVVVAVFIVCWTPIHIYVIIKAlVTIPET 313
Cdd:cd15209  164 VVVIHFLLPLLIVSFCYlriwVLVLQVRQRVKPDQRPKLKPADVRNFLTM-FVVFVLFAVCWAPLNFIGLAVA-INPKEM 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 550822324 314 TFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15209  242 APKIPEWLFVASyfMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
71-349 1.22e-23

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 99.87  E-value: 1.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15056    1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLvAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCnWILSSAIG-LPVM---------FMATTKYRQGSIDC 219
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGC-WVIPTFISfLPIMqgwnhigieDLIAFNCASGSTSC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 220 TLTFSHPtwywenLLKICVFIfAFIMPVLIITVCYGLMIL----RLKSVRML--SGSKEKDRNLRRITRMVLVVVAVFI- 292
Cdd:cd15056  160 VFMVNKP------FAIICSTV-AFYIPALLMVLAYYRIYVaareQAHQIRSLqrAGSSNHEADQHRNSRMRTETKAAKTl 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 293 --------VCWTPIHIYVIIKALVtipETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15056  233 giimgcfcVCWAPFFVTNIVDPFI---GYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
75-351 1.29e-23

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 99.64  E-value: 1.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVG-LFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 152
Cdd:cd15307    4 ALLALVLVLGtAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMvAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPtwywen 232
Cdd:cd15307   84 CTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIPDP------ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIITVCYGLmilrlkSVRMLSGSKEKD-RNLR---RITRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15307  158 VYKLVGSIVCFYIPLGVMLLTYCL------TVRLLARQRSRHgRIIRleqKATKVLGVVFFTFVILWSPFFVLNLLPTVC 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 309 TIPET-----TFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCFRE 351
Cdd:cd15307  232 AECEErishwVFDVVTW-----LGYASSMVNPIFYTIFNKVFRQAFKK 274
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
73-349 1.88e-23

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 99.25  E-value: 1.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15125    3 IPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPvkaLDFRTprNAKIINVCN-----WILSSAIGLPVMFMATTKYRQGSIDCTLTFSHP 226
Cdd:cd15125   83 SVGVSVFTLTALSADRYKAIVNP---MDIQT--SSAVLRTCLkaiaiWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TWYWENLL----KICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSG-----SKEKDRNLRRITRMVLVVVAVFIVCWT 296
Cdd:cd15125  158 YPQTDEMHpkihSVLIFLVYFLIPLAIISIYYYHIAKTLiKSAHNIPGeysehSKRQMETRKRLAKIVLVFVGLFAFCWF 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 297 PIHIYVIIKAL--VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15125  238 PNHVLYMYRSFnyNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
71-349 1.92e-23

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 99.46  E-value: 1.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQsVNYLMGTWPF--GTILCKIVIS 147
Cdd:cd15358    1 TPVCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLgMPLE-LYEMWSNYPFllGAGGCYFKTL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPV-----MFMATTKYRQ---GSIDC 219
Cdd:cd15358   80 LFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNtslhgIFQLTVPCRGpvpDSATC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 220 TLTfsHPTWYWENLLKICVFIFaFIMPVLIITVCYGLMILRLKSVRMLS-----GSKE-----------KDRNLRRITRM 283
Cdd:cd15358  160 MLV--KPRWMYNLIIQITTLLF-FFLPMGTISVLYLLIGLQLKREKMLLvleakGSKAgdsyqhrriqqEKRRRRQVTKM 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550822324 284 VLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALG---YTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15358  237 LFVLVVVFGICWAPFHTDRLMWSFISQWTGELHLAFQYVHIISGvffYLSSAANPVLYNLMSTRFREMF 305
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-349 1.97e-23

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 99.15  E-value: 1.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA-LATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd16004    7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLsMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKaldfrtPR----NAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd16004   87 SIYSMTAIAADRYMAIIHPFK------PRlsagSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLL-KICVFIFAFIMPVLIITVCYGLMILRLKSvRMLSGSKEKDRNL------RRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd16004  161 QLTyHLAVIVLIYLLPLAVMFVTYSIIGITLWR-SAVPGHQAHGAYHrqlqakKKFVKTMVVVVVTFAICWLPYHLYFIL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 305 KAL-VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd16004  240 GSFnEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
78-347 2.08e-23

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 99.32  E-value: 2.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  78 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL--ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15337    8 AIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGfsAVNGFPLKTISSFNKKWIWGKVACELYGFAGGIFGFM 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVmFMATTKYRQGSIDCTLTFSHPTWYWENLLK 235
Cdd:cd15337   88 SITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPP-FFGWGRYVPEGFQTSCTFDYLSRDLNNRLF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 I-CVFIFAFIMPVLIITVCYG--LMILRLKSVRML----------SGSKEKDRNLR-RITRMVLVVVAVFIVCWTPihiY 301
Cdd:cd15337  167 IlGLFIFGFLCPLLIIIFCYVniIRAVRNHEKEMTqtaksgmgkdTEKNDARKKAEiRIAKVAIILISLFLLSWTP---Y 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 302 VIIkALVTI--PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15337  244 AVV-ALLGQfgPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRA 290
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
76-343 3.65e-23

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 98.33  E-value: 3.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLM--GTWPFGTILCKIVISIDYYNM 153
Cdd:cd15366    6 LYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLW-IDYFLhrDNWIHGPESCKLFGFIFYTNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILS-SAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY-WE 231
Cdd:cd15366   85 YISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEiGANSAPLFHDELFRDRYNHTFCFEKYPMEDWVaWM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVfifAFIMPVLIITVCY-GLmilrLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALV-- 308
Cdd:cd15366  165 NLYRVFV---GFLFPWVLMLFSYrGI----LRAVRGNVSTEQQEK--AKIKRLALSLIAIVLLCFAPYHVLLLSRSVVyl 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 309 ------TIPETTFqtVSWHFCIALGYTNSCLNPVLYAFLDE 343
Cdd:cd15366  236 gkpcdcGFEERVF--TAYHVSLALTSLNCVADPILYCLVNE 274
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
71-349 5.66e-23

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 97.51  E-value: 5.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGT-WPFGTILCKIVISI 148
Cdd:cd15302    1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLiGLESMPFYTVYVLNGDyWPLGWVLCDLWLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI----DCTLTFS 224
Cdd:cd15302   81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQGRSlpegECYVQFM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 hptwywENLLKICVFIFAFIMPVLIITVCYGLMILRLksvrmlsgSKEKDRNLRRITrmvlVVVAVFIVCWTPIHIYVII 304
Cdd:cd15302  161 ------TDPYFNMGMYIGYYWTTLIVMLILYAGIYRA--------ANRARKALRTIT----FILGAFVICWTPYHILATI 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 305 KALVTIPE---TTFQTVSWHFCialgYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15302  223 YGFCEAPPcvnETLYTISYYLC----YMNSPINPFCYALANQQFKKTF 266
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
74-343 6.07e-23

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 97.54  E-value: 6.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLMG--TWPFGTILCKIVISIDYY 151
Cdd:cd15365    4 PFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLW-IDYLWNgdNWTLSGFVCIFSAFLLYT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGlPVMFMATTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd15365   83 NFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFN-AVILTWEDSFHESSSHTLCYDKFPLEDWQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFIMPVLIITVCYGLMilrLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIP 311
Cdd:cd15365  162 ARLNLFRICLGYLLPLLIILFCYWKI---YQAVRSNQATEDQEK--KKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPC 236
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 550822324 312 ETTFQT---VSWHFCIALGYTNSCLNPVLYAFLDE 343
Cdd:cd15365  237 DCRNAKwlyTLYKITVALTSLNCIADPFLYCFVTE 271
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
75-349 1.18e-22

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 97.29  E-value: 1.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15959    5 ALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADlVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMfmaTTKYRQGS-IDCTLTFSHPtwywe 231
Cdd:cd15959   85 TASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISfLPIM---NQWWRDGAdEEAQRCYDNP----- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 nllKICVFI-----------FAFIMPVLIITVCYG-LMILRLKSVRMLSG------------SKEKDRNLRRITRMVL-- 285
Cdd:cd15959  157 ---RCCDFVtnmpyaivsstVSFYVPLLVMIFVYVrVFVVATRQVRLIRKdkvrfppeesppAESRPACGRRPSRLLAik 233
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 286 ---------VVVAVFIVCWTPIHIYVIIKALVT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAfLDENFKRCF 349
Cdd:cd15959  234 ehkalktlgIIMGTFTLCWLPFFVANIIKVFCRslVPDPAFLFLNW-----LGYANSAFNPIIYC-RSPDFRSAF 302
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
71-346 1.26e-22

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 96.78  E-value: 1.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 149
Cdd:cd15199    1 IAYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGnRWSLGGGTCKALLFML 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKyrqGSIDCTLTFSHPTWY 229
Cdd:cd15199   81 SLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPK---NFTECNSFSPKDDED 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15199  158 FSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQPK---LQRAMALVTSVVVVFGFCFLPCFLARVLMLIFQ 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 310 IPETtfqtvSWHFCIA---------LGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15199  235 NKES-----CNALNIAvhtydvtmcLTYLNSVLDPIVYCFSSPTFR 275
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
78-338 1.58e-22

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 96.74  E-value: 1.58e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  78 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15384    8 AVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFfCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLP--VMFMATTKYRQGSIDCTLTFSHPTWYW-ENL 233
Cdd:cd15384   88 TYITVLISLDRCVAILYPMKRN--QAPERVRRMVTVAWILSPIFSIPqaVIFHVERGPFVEDFHQCVTYGFYTAEWqEQL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNL------------RRITRMVLVVVAVFIVCWTPIHI 300
Cdd:cd15384  166 YNMLSLVFMFPIPLVIMVTCYVLIFITLsKSSRDFQGLEIYTRNRgpnrqrlfhkakVKSLRMSAVIVTAFILCWTPYYV 245
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822324 301 YVIIKALVTIPETTFQTVSWHFciALGYTNSCLNPVLY 338
Cdd:cd15384  246 IMIWFLFFNPYPLNDILFDVIF--FFGMSNSCVNPLIY 281
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
80-349 1.84e-22

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 96.34  E-value: 1.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  80 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLP-FQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIF 158
Cdd:cd15000    9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPwMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 159 TLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGS----IDCTLTFSHPTWYWENLL 234
Cdd:cd15000   89 ALCAVSYDRLTAIVLPSEAR--LTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQWKnfleTYCAENTQVLPIYWHVII 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIfafimPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR---RITRMVLVVVAVFIVCWTPIHIYVIIKALVTIP 311
Cdd:cd15000  167 TVLVWL-----PLGIMLICYSAIFWKLDKYERRVLRREHPSVVRykkKAAKTLFIVLITFVVCRIPFTALIFYRYKLVPN 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 312 ETTFQTVS------WHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15000  242 DNTQNSVSgsfhilWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
71-347 2.43e-22

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 96.25  E-value: 2.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15083    1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILnCPLMVISSFSGRWIFGKTGCDMYGFSG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQG-----SIDCTLTFS 224
Cdd:cd15083   81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGlltscSFDYLSRDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWenllkICVFIFAFIMPVLIITVCYGLMILRL------------KSVRMLSGSKEKDRNLR-RITRMVLVVVAVF 291
Cdd:cd15083  161 ANRSYV-----ICLLIFGFVLPLLIIIYCYSFIFRAVrrhekamkemakRFSKSELSSPKARRQAEvKTAKIALLLVLLF 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 292 IVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIAlgYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15083  236 CLAWTPYAVVALIGQFGYLEVLTPLATAIPAAFA--KTSAIYNPVIYAFSHPKFRR 289
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
74-349 2.66e-22

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 96.11  E-value: 2.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 152
Cdd:cd15980    4 IASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLvGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPVMFMATTK--------YRQGSIDCTLTFS 224
Cdd:cd15980   84 VSASVFTLVAIAVDRFRCIVYPFKQK--LTISTAVVIIVIIWVLAIAIMCPSAVMLHVQeeknyrvvLGSQNKTSPVYWC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWENLLKI---CVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEK-------DRNLRRITRMVLVVVAVFIVC 294
Cdd:cd15980  162 REDWPNQEMRKIyttVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNqeqrhvvSRKKQKVIKMLLIVALLFILS 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 550822324 295 WTPIHIYVIIKALVTIPETTFQTVS---WHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15980  242 WLPLWTLMMLSDYANLSPNQLQIINiyiYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
79-349 3.00e-22

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 95.50  E-value: 3.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNMFTSI 157
Cdd:cd15201    9 LEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKhWKFGDIPCRIVLFMLAMNRAGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 158 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDC----TLTFSHPTWYWENL 233
Cdd:cd15201   89 FFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQCesfnICTGTDSSSNWHEA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LkicvFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdrnLRRITRMVLVVVAVFIVCWTP-----IHIYVIIKALV 308
Cdd:cd15201  169 M----FLLEFFLPLAIILYCSVRIIWQLRGRQLDRHAK-----IKRAVQFIMVVAIVFIICFLPsnvtrIAIWILKHTSN 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 309 TI-PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15201  240 EDcQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
82-349 4.38e-22

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 95.50  E-value: 4.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTL 160
Cdd:cd15312   12 LLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLvMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 161 CTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFmaTTKYRQG------SIDCT----LTFSHptwYW 230
Cdd:cd15312   92 CFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVF--SEVNLEGiedyvaLVSCTgscvLIFNK---LW 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLkicvFIFAFIMPVLIITVCYG-LMILRLKSVRMLS--------GSKEK--DRNLRRITRMVLVVVAVFIVCWTPIH 299
Cdd:cd15312  167 GVIA----SLIAFFIPGTVMIGIYIkIFFVARKHAKVINnrpsvtkgDSKNKlsKKKERKAAKTLSIVMGVFLLCWLPFF 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 300 IYVIIKALV--TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15312  243 VATLIDPFLnfSTPVDLFDALVW-----LGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
71-347 1.07e-21

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 94.21  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15401    1 SVLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADlVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15401   81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenllKICVFIFAFIMPVLIITVCY---GLMILRLK-SVRMLSGSKEKDRNLRRITRMvLVVVAVFIVCWTP---IHIYV 302
Cdd:cd15401  161 -----TITVVVVHFIVPLSIVTFCYlriWVLVIQVKhRVRQDSKQKLKANDIRNFLTM-FVVFVLFAVCWGPlnfIGLAV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 303 IIKALVTIPETTfqtvSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15401  235 AINPLKVAPKIP----EWLFVLSyfMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
73-349 1.43e-21

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 93.49  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd17790    3 IVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADlIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMatTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd17790   83 ASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILF--WQYLVGERTVLAGQCYIQFLSQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFIMPVLIitvcygLMILRLKSVRMLSGSKEKDRNLRRItrmvlvvVAVFIVCWTPIHIYVIIKALVT-- 309
Cdd:cd17790  161 PIITFGTAIAAFYLPVTI------MIILYWRIYRETIKEKKAARTLSAI-------LLAFILTWTPYNIMVLVSTFCKdc 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd17790  228 VPKTLWELGYW-----LCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
76-349 1.92e-21

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 93.71  E-value: 1.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISID----Y 150
Cdd:cd14996    6 IYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFyWKYQSTQCRIANFFGtlviH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRY-IAVCH--------------PVKALD-FRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ 214
Cdd:cd14996   86 VSMCVSILILSWIAISRYaTLMKHdsatqkqscyekifYGHFLKrFRQPKFARYLCIYIWGVVLCIIIPVVVYYSVREAD 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 215 GSIDcTLTFSHPTWYWENLLKICVFI---FAFIMPVLIITVCYGLmILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVF 291
Cdd:cd14996  166 EDGE-SLCYNRQVELGAKGSQIAGLIattFFFLFFLVVLLSYYSF-VNHLRRIQKNTCISEKDLIYRSVKRNILIIQALL 243
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550822324 292 IVCWTPIHIYVIIKALVTIPETTFQTVSW----HFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14996  244 VVCFLPYHIFKPVFYVLHQREDCQQLNYLietkNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
71-346 1.98e-21

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 92.93  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTwpfGTILCKIVISIDY 150
Cdd:cd15163    1 LALMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAG---NCLTCSFVHIFSY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 Y-NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMfmaTTKYRQGSIDCTLTFShptwy 229
Cdd:cd15163   78 FvNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSIL---TTAIKFASCCLSKLFA----- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenllkicVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRnlrRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15163  150 --------LTVFEFFLPLLIITFFTIRIMCALSRPGLMHQSRERRM---RAVQLLITVLIIFMICFTPFHVRQVAVAFNP 218
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 310 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15163  219 DIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
71-349 2.02e-21

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 92.96  E-value: 2.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADfAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPvmFMATTKYRQGSID-----CTLTFS 224
Cdd:cd15301   81 YLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPP--WIYSWPYIEGKRTvpagtCYIQFL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYwenlLKICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15301  159 ETNPY----VTFGTALAAFYVPVTIMCILYWRIWRETK--------KRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLI 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 305 KALVTIPETTfQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15301  227 KAFFPCSDTI-PTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
76-339 2.28e-21

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 93.41  E-value: 2.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15079    6 IYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCnWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLK 235
Cdd:cd15079   86 SIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFI-WLYALPWALLPLLFGWGRYVPEGFLTSCSFDYLTRDWNTRSF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 I-CVFIFAFIMPVLIITVCYGLMI---------LRLKSVRMLSGSKEKDRNLR------RITRMVLVVVAVFIVCWTPIH 299
Cdd:cd15079  165 VaTIFVFAYVIPLIIIIYCYSFIVkavfahekaLREQAKKMNVVSLRSNADANkqsaeiRIAKVALTNVFLWFIAWTPYA 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 300 IYVII-----KALVTiPETTfqtvSWHFCIAlgYTNSCLNPVLYA 339
Cdd:cd15079  245 VVALIgafgnQSLLT-PLVS----MIPALFA--KTAACYNPIVYA 282
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
76-338 2.56e-21

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 93.39  E-value: 2.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15957    6 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADlVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFSHPTWYWENL 233
Cdd:cd15957   86 ASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSfLPIQMHWYRATHQEAINCYAEETCCDFFTNQA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNLRRITRMVLVVVAVF------------------ 291
Cdd:cd15957  166 YAIASSIVSFYVPLVIMVFVYSRVFQeakrQLQKIDKSEGRFHNQNIDQNGSGGGGGNRRRSkfclkehkalktlgiimg 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 292 --IVCWTPIHIYVIIKAL--VTIPETTFQTVSWhfciaLGYTNSCLNPVLY 338
Cdd:cd15957  246 tfTLCWLPFFIVNIVHVIqdNLIRKEVYILLNW-----IGYVNSGFNPLIY 291
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
77-347 4.14e-21

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 92.48  E-value: 4.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15152    7 YTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI--------DCTLTFShptw 228
Cdd:cd15152   87 IYFLVCISVRRCLYLIYPFRYND-CKRKCDVYISIAGWLVVCVGCLPFPLLRQSQDTNPTCcfadlplrNVGLTTS---- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 yweNLLKICVFIFAFIMPVLIITVCYGLMILRLK-SVRMLSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15152  162 ---VIMLTIAELTGFVTPLLIVLYCSWKTVMSLReKTPVLQDLGEKKKAL----KMILTCAVVFLICFAPYHISFPLDFL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 308 VT---IPETTFQTVSWHF---CIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15152  235 VKsnkIKSCTARKVILIFhpvALCLASLNSCLDPVIYYFTTDEFKR 280
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
71-347 4.34e-21

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 92.17  E-value: 4.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLMGTWPFgtILCKIVISIDY 150
Cdd:cd15920    1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFR-VAYQNTAGPL--SFCKIVGAFFY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFmatTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd15920   78 LNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLF---ESRNEGPCDNKCFHFRSKGLT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIItVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI----YVI--I 304
Cdd:cd15920  155 AGGINLTAVVIFYILSLLFL-YFYAKISHKLYKVSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHIvrvpYVLaqI 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 305 KALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15920  234 DVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
75-346 5.31e-21

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 92.17  E-value: 5.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 153
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNnWIYGEALCKVLIGFFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVkALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQgsiDCTLTFSHPTWYwENL 233
Cdd:cd15370   85 YCSILFMTCLSVQRYWVIVNPM-SHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIP---ALDITTCHDVLP-EQL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIF-------AFIMPVLIITVCYGLMILRLKSVrMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTPIHIYVIIK- 305
Cdd:cd15370  160 LVGDMFNYflslaigVFLFPAFLTAVAYVLMIRALKSS-INDESIEKKRK--RAIKLIVTVLVMYLICFTPSNLLLVVHy 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 306 ALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15370  237 FLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
72-348 6.33e-21

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 91.95  E-value: 6.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALY-SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTL-PFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15074    1 IIIGIYlTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIISAFAHRWLFGDIGCVFYGFCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIInVCNWILSS--AIgLPVMFMATTKYRQGSIDCTLTFSHPT 227
Cdd:cd15074   81 FLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVI-VAIWLYALfwAV-APLVGWGSYGPEPFGTSCSIDWTGAS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLL-KICVFIFAFIMPVLIITVCYGLMILRLKSVRML---SGSKEKDRNL--RRITRMVLVVVAVFIVCWTPihiY 301
Cdd:cd15074  159 ASVGGMSyIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRvagFDSRSKRQHKieRKVTKVAVLICAGFLIAWTP---Y 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 302 VIIKALVT------IPETTFQTVSwhfciALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15074  236 AVVSMWSAfgspdsVPILASILPA-----LFAKSSCMYNPIIYLLFSSKFRQD 283
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
76-347 6.96e-21

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 91.74  E-value: 6.96e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15924    6 LYTVIFFAGILLNGLAMWIFF-HIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAgLGPWQLRTFVCRVTSVLFYFTMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLL 234
Cdd:cd15924   85 TSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKKCSFLKSELGLKWHEI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIyviikalVTIPET 313
Cdd:cd15924  165 VNYICQVIFWIVFLLMIVCYTAITKKVyRSYRRVFRSSSSRR--KKSNVKIFIIVAVFFVCFVPYHF-------ARIPYT 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 314 TFQTVSWHFCIA-------------LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15924  236 LSQTRDVFDCTAenilfyvkeatlfLSALNVCLDPIIYFFLCKSFRE 282
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
71-349 7.23e-21

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 91.40  E-value: 7.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15333    5 ISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSIlVMPISIVYTVTGTWTLGQVVCDIWLSSD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWy 229
Cdd:cd15333   85 ITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTDHILY- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenllKICVFIFAFIMPVLIITVCYGlmilrlksvRMLSGSKEKDrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15333  164 -----TVYSTVGAFYIPTLLLIALYG---------RIYVEARARE---RKATKTLGIILGAFIVCWLPFFIISLVLPICK 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 iPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15333  227 -DACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
79-340 7.39e-21

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 92.10  E-value: 7.39e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA--TSTLPFQSVNYlMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15197    9 VLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVglINVLTDIIWRI-TVEWRAGDFACKVIRYLQVVVTYAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALdfRTPRNAKIINVCNWILSSAIGLPVMFMA-TTKYRQGSIDCTLTFSHPtWYWENLLK 235
Cdd:cd15197   88 TYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSALFSIPMLIIFeKTGLSNGEVQCWILWPEP-WYWKVYMT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFaFIMPVLIITVCYGLMI--------LRLKSVRMLSGSKEKDRNLRR--ITR-------MVLVVVAVFIVCWTPI 298
Cdd:cd15197  165 IVAFLV-FFIPATIISICYIIIVrtiwkkskIQVTINKAGLHDGSSRRSSSRgiIPRakiktikMTFVIVTVFIICWSPY 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 299 HIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 340
Cdd:cd15197  244 FVFDLLDVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCL 285
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
76-342 7.73e-21

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 91.34  E-value: 7.73e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPF-GTILCKIVISIDYYNMF 154
Cdd:cd14964    4 ILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGANL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKyrqgSIDCTLTFSHPTWYWENLL 234
Cdd:cd14964   84 ASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAI----PRYNTLTGSCYLICTTIYL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVCYGLMILRLKS---VRMLSGSKEKDRNLRRiTRMVLVVVAVFIVCWTPIHIYVIIKALVTIP 311
Cdd:cd14964  160 TWGFLLVSFLLPLVAFLVIFSRIVLRLRRrvrAIRSAASLNTDKNLKA-TKSLLILVITFLLCWLPFSIVFILHALVAAG 238
                        250       260       270
                 ....*....|....*....|....*....|.
gi 550822324 312 ETTFQTVSWHFciALGYTNSCLNPVLYAFLD 342
Cdd:cd14964  239 QGLNLLSILAN--LLAVLASTLNPFIYCLGN 267
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
71-349 9.24e-21

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 91.24  E-value: 9.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15300    1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADlIIGIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFmaTTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15300   81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPIL--CWQYFVGKRTVPERECQIQFL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15300  159 SEPTITFGTAIAAFYIPVSVMTILY---------CRIYKETIKE----RKAAQTLSAILLAFIITWTPYNIMVLVSTFCS 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 310 --IPETTfqtvsWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15300  226 dcIPLTL-----WHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
71-346 9.35e-21

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 91.78  E-value: 9.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWPFGTILCKIVISID 149
Cdd:cd15132    1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRlWKSRPWIFGEFLCRLYHYIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFS-HPTW 228
Cdd:cd15132   81 EGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSREcKHTP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVFIFA----FIMPVLIITVCYGLMILRL-KSVRMLSG--SKEKDRNLRRITRMVLVVVAVFIVCWTPIHIY 301
Cdd:cd15132  161 YAVSSGLLGIMIWVtttyFFLPMLCLSFLYGFIGRKLwKSKNDLRGpnAAARERSHRQTVRILAVVVLAFIICWLPFHIG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 302 VIIKALVTIPETTFqtVSWHFCIA---LGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15132  241 RILFANTEDYRTMM--FSQYFNIVamqLFYLSASINPILYNLISRKYR 286
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
71-349 1.03e-20

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 91.42  E-value: 1.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15399    1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKAlDFRTPRNAKIINVcNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15399   81 ALAVHVSTVTLTVIALDRHRCIVYHLES-KISKKISFLIIGL-TWAASALLASPLAIFREYSVIEISPDFKIQACSEKWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WEN-----LLKICVFIFAFIMPVLIITVCYGLMILRLKS-VRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV- 302
Cdd:cd15399  159 NGTlndgtIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNhVSPGGGNDHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQl 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 550822324 303 ---IIKALVTIPETTFQTVSWHFcIALGYTNSclNPVLYAFLDENFKRCF 349
Cdd:cd15399  239 asdIDSKVLDLKEYKLIYTIFHV-IAMCSTFA--NPLLYGWMNNNYRTAF 285
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
79-347 1.12e-20

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 91.66  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVR-YTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15383    9 VLFVLSACSNLAVLWSATRnRRRKLSHVRILILHLAAADLLVTfVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSID---CTLTFSHPTWYWENL 233
Cdd:cd15383   89 AFVTVVISLDRHAAILNPLAIGSAR--RRNRIMLCAAWGLSALLALPQLFLFHTVTATPPVNftqCATHGSFPAHWQETL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLR-----------RITRMVLVVVAVFIVCWTPihIY 301
Cdd:cd15383  167 YNMFTFFCLFLLPLLIMIFCYTRILLEIsRRMKEKKDSAKNEVALRsssdnipkarmRTLKMTIVIVSSFIVCWTP--YY 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 302 VIIKALVTIPETTFQTVS---WHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15383  245 LLGLWYWFSPEMLEQTVPeslSHILFLFGLLNACLDPLIYGLFTISFRR 293
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
76-349 1.13e-20

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 90.80  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFqsVNYLM---GTWPFGTILCKIVISIDYY 151
Cdd:cd15310    6 SYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLvATLVMPW--VVYLEvtgGVWNFSRICCDVFVTLDVM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVK---ALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKyrqgSIDCTLTFSHPTW 228
Cdd:cd15310   84 MCTASILNLCAISIDRYTAVVMPVHyqhGTGQSSCRRVSLMITAVWVLAFAVSCPLLFGFNTT----GDPTVCSISNPDF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YwenllkICVFIFAFIMPVLIITVCYGLMILRLksvrmlsgSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKA-- 306
Cdd:cd15310  160 V------IYSSVVSFYLPFGVTLLVYVRIYVVL--------LREK-----KATQMLAIVLGAFIVCWLPFFLTHILNThc 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 307 -LVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15310  221 qACHVPPELYSATTW-----LGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
71-349 1.14e-20

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 90.80  E-value: 1.14e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA-LATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15297    1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLiIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMatTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15297   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILF--WQFIVGGRTVPEGECYIQFF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYGLMilrlksvrmlsgSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15297  159 SNAAVTFGTAIAAFYLPVIIMTVLYWQI------------SRASSRE-KKVTRTILAILLAFIITWTPYNVMVLINTFCA 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 310 --IPETTfqtvsWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15297  226 scIPNTV-----WTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
71-346 1.20e-20

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 91.04  E-value: 1.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15166    1 IAALVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd15166   81 FYPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNFTTCLKMLDIIHLK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 E-NLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15166  161 EvNVLNFTRLIFFFLIPLFIMIGCYLVIIHNLVHGRT---SKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAFLMLQN 237
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 310 iPETTFQTVSwHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15166  238 -GDNSYNPWA-AFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
79-349 2.16e-20

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 90.69  E-value: 2.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPF-----GTILCKIVISIDYYN 152
Cdd:cd15975    9 IIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIyIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPFLQKAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP---VMFMATTKYRQGSI-DCTLTFSHP-T 227
Cdd:cd15975   89 VGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPeaiGFVMVPFEYNGEQYrTCMLNATTKfM 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMIL-----RLKSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYV 302
Cdd:cd15975  169 NFYVDAKDWWLFGFYFCVPLACTAIFYTLMTCemlnrRKGSLRIALSEHLKQR--REVAKTVFCLVVIFALCWFPLHLSR 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822324 303 IIKALVTIPET-------TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15975  247 ILKKTVYNENDprrcellSFLLVMDYISINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
79-349 2.43e-20

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 90.68  E-value: 2.43e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSI 157
Cdd:cd15976    9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIdIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 158 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF---MATTKYRQGSIDCTLTfsHPTW------ 228
Cdd:cd15976   89 LSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIgfdMITMDYKGELLRICLL--HPIQktafmq 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVFIFAFIMPVLIITVCYGLM---ILRLKSvRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd15976  167 FYKTAKDWWLFSFYFCLPLACTAVFYTLMtceMLRKKN-GMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILK 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 306 ALVTIPETTFQTVSWHFCIALGYT-------NSCLNPVLYAFLDENFKRCF 349
Cdd:cd15976  246 LTIYDEKDPNRCELLSFFLVLDYIginmaslNSCINPIALYLVSKRFKNCF 296
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
76-349 4.28e-20

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 89.36  E-value: 4.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15066    5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLvALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVM--FMATTKYRQGSIdctltfSHPTwywe 231
Cdd:cd15066   85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISfLPIFlgWYTTEEHLQYRK------THPD---- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 nllkICVFI-----------FAFIMPVLIITVCYglmilrlksVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHI 300
Cdd:cd15066  155 ----QCEFVvnkiyalisssVSFWIPCIVMIFTY---------YRIYLEAKRE----HKAAKTLGIIMGAFILCWLPFFL 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 301 YVIIKAL----VTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15066  218 WYVTTTLcgdaCPYPPILVSILFW-----IGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
71-353 4.51e-20

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 88.96  E-value: 4.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15213    1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDiMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIINVCNWILSSAIGLPVMFmATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15213   81 WFFVLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLV-GWGKYEFPPRAPQCVLGYTESP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYgLMILRlkSVRMLsgskeKDRNLRRItrmvLVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15213  157 ADRIYVVLLLVAVFFIPFLIMLYSY-FCILN--TVRSF-----KTRAFTTI----LILFIGFSVCWLPYTVYSLLSVFSR 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 310 IPETTFQTVSWhfCIALGYTNSCLNPVLYAFldenFKRCFREFC 353
Cdd:cd15213  225 YSSSFYVISTC--LLWLSYLKSAFNPVIYCW----RIKKFREAC 262
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
79-349 4.93e-20

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 88.74  E-value: 4.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGlfGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLP-FQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15308   11 ILAIIA--GNVLVCLSVCTERALKTTTNYFIVSLAVADLLlALLVLPlYVYSEFQGGVWTLSPVLCDALMTMDVMLCTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTfshptwywENLLKI 236
Cdd:cd15308   89 IFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVCKLE--------DNNYVV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 237 CVFIFAFIMPVLIITVCYGLMILRLksvrmlsgSKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL---VTIPET 313
Cdd:cd15308  161 YSSVCSFFIPCPVMLVLYCAMFRGL--------GRE-----RKAMRVLPVVVGAFLFCWTPFFVVHITRALcesCSIPPQ 227
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 550822324 314 TFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15308  228 LISIVTW-----LGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
72-263 5.18e-20

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 89.39  E-value: 5.18e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15336    2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHKRWIFGEKGCELYAFCGA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQG-SIDCT---LTFSHP 226
Cdd:cd15336   82 LFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGlLTSCTwdyMTFTPS 161
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 550822324 227 TWYWENLLkicvFIFAFIMPVLIITVCYGLMILRLKS 263
Cdd:cd15336  162 VRAYTMLL----FCFVFFIPLGIIIYCYLFIFLAIRS 194
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
82-347 5.26e-20

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 89.14  E-value: 5.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTL 160
Cdd:cd15400   12 VVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADlVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 161 CTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYwenllKICVFI 240
Cdd:cd15400   92 TGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQTASSSY-----TIAVVV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 241 FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDR----NLRRITRMvLVVVAVFIVCWTPIHIYVIIKAlVTIPETTFQ 316
Cdd:cd15400  167 IHFIVPITVVSFCYLRIWVLVIQVRRKVKSESKPRlkpsDFRNFLTM-FVVFVIFAICWAPLNLIGLAVA-INPQEMAPK 244
                        250       260       270
                 ....*....|....*....|....*....|...
gi 550822324 317 TVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15400  245 VPEWLFVVSyfMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
74-349 6.42e-20

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 89.24  E-value: 6.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATstlpfqsvnyLMGtwpfgtILCKIVISIDYYNM 153
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVG----------ALA------IPLAILISLGLPTN 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 F---------------TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF------MATTKY 212
Cdd:cd14968   68 FhgclfmaclvlvltqSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFgwnngaPLESGC 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 213 RQGSIDCTLTFSHPTWYwenllkICVFIF-AFIM-PVLIITVCYGLMILR----LKSVRMLSGSKEKDRNLRR---ITRM 283
Cdd:cd14968  148 GEGGIQCLFEEVIPMDY------MVYFNFfACVLvPLLIMLVIYLRIFRVirkqLRQIESLLRSRRSRSTLQKevkAAKS 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550822324 284 VLVVVAVFIVCWTPIHiyvIIKALVTIPETTFQTVSW-HFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14968  222 LAIILFLFALCWLPLH---IINCITLFCPECKVPKILtYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
74-340 7.91e-20

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 89.09  E-value: 7.91e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATStlpFQSVNYLMG--TWPF-GT-ILCKIVISID 149
Cdd:cd15386    4 IGVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVAL---FQVLPQLIWeiTYRFqGPdLLCRAVKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDfRTPRNAKIINVCNWILSSAIGLPVMFM-ATTKYRQGS--IDCTLTFSHP 226
Cdd:cd15386   81 VLSMFASTYMLIMMTVDRYIAVCHPLRTLQ-QPSRQAYLMIGATWLLSCILSLPQVFIfSLREVDQGSgvLDCWADFGFP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 -------TWyweNLLKIcvfifaFIMPVLIITVCYGLMIL---------------------------RLKSVRMLSGSKe 272
Cdd:cd15386  160 wgakayiTW---TTLSI------FVLPVAILIVCYSLICYeicknlkgktqtsrsegggwrtqgmpsRVSSVRTISRAK- 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550822324 273 kdrnlRRITRMVLVVVAVFIVCWTP---IHIYVIIKalVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 340
Cdd:cd15386  230 -----IRTVKMTFVIVLAYIACWAPffsVQMWSVWD--ENAPDEDSSDFAFTITMLLASLSSCCNPWIYMF 293
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
77-347 8.27e-20

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 89.04  E-value: 8.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIF--NLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15147    7 YSIIFVLGLIANCYVLWVFARLYPSKKLNEIKIFmvNLTIADLLFLITLPFWIVYYHnEGNWILPKFLCNVAGCLFFINT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFM-ATTKYRQGSIDCTLTFSHPTWYWEN 232
Cdd:cd15147   87 YCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMdSTNTVKIDSGNFTRCFEGYEKDNSK 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVF--IFAFIMPVLIITVCyGLMILRLKSVRMLSGSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIyviikalVTI 310
Cdd:cd15147  167 PVLIIHFiiIGLFFLVFLLILVC-NLVIARTLLSQPVQGQRNAGVK-RRALWMVCTVLAVFVICFVPHHV-------VQG 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 311 PETTFQTVSWHF---------------CIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15147  238 PWTLAVLQQWRYwdcqfrqalndahqiTLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
71-346 8.75e-20

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 88.47  E-value: 8.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFqsVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15164    1 LIQLIIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPF--VLYFLKHSWPDDELCLVLQSIYF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILssaiglpVMFMATTKYRQGSIDCTLTFsHPTWYW 230
Cdd:cd15164   79 INRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVL-------VIISVSLRLAWEEQEENFCF-GKTSTR 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrNLRRITRMVLVVVAVFIVCWTPIHIYVIIK---AL 307
Cdd:cd15164  151 PSKRTLIFSLLGFFIPLIILSFCSIQVIRSLKKKKKTNPHEEK--LIQKAIYIVSANLIVFIVCFLPLHIGLLVRfvmES 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 308 VTIPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15164  229 NKASCSLIQNIRNFIYVAscLANANCCLDAICYYFVAKEFQ 269
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
73-347 9.70e-20

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 88.72  E-value: 9.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMAL-YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15395    2 TLALaYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTiMCLPFTFVYTLMDHWVFGEAMCKLNSMVQC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPvkaLDFR-TPRNAKIINVCNWILSSAIGLPVM---------FMATTKYRQGSIDCT 220
Cdd:cd15395   82 ISITVSIFSLVLIAIERHQLIINP---RGWRpNNRHAYVGIAVIWVLAVLTSLPFLifqvltdepFKNVNVSLDAYKGKY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 221 LTFSH-PTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKS----VRMLSGSKEKDRNLRRITRMVLVVVAVFIVCW 295
Cdd:cd15395  159 VCLDQfPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRrnnmMDKMRDNKYRSSETKRINIMLISIVVAFAVCW 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 296 TPIHIY-VIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15395  239 LPLNIFnAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQR 291
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
72-349 1.49e-19

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 87.77  E-value: 1.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGlfgNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15298    5 TVTGSLSLVTVVG---NILVMLSIKVNRQLQTVNNYFLFSLACADlIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI---DCTLTF-SHP 226
Cdd:cd15298   82 VVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVpdnQCFIQFlSNP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TwywenlLKICVFIFAFIMPVLIITVCYglMILRLKSVRMlsgskekdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKA 306
Cdd:cd15298  162 A------VTFGTAIAAFYLPVVIMTVLY--IHISLASARE-----------RKVTRTIFAILLAFILTWTPYNVMVLVNT 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 307 LVT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15298  223 FCQscIPDTVWSIGYW-----LCYVNSTINPACYALCNATFKKTF 262
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
73-349 5.50e-19

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 86.49  E-value: 5.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15124    3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIINV---CNWILSSAIGLP-VMFMATTKYRQGSIDCTLT----F 223
Cdd:cd15124   83 SVGVSVFTLTALSADRYKAI---VRPMDIQASNALMKICLkaaLIWILSMLLAIPeAVFSDLHPFYDKSTNKTFVscapY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 224 SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLM---ILRLKSVRMLSG---SKEKDRNLRRITRMVLVVVAVFIVCWTP 297
Cdd:cd15124  160 PHSNELHPKIHSMASFLIFYVIPLSIISVYYYFIaknLIRSAYNLPVEGnvhVRRQIESRKRLAKTVLVFVGLFAFCWLP 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 550822324 298 IHIYVIIKALvtiPETTFQTVSWHFCIA-----LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15124  240 NHIIYLYRSY---HYSEVDTSMLHFVSSicariLAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
75-347 6.07e-19

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 86.47  E-value: 6.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYYNM 153
Cdd:cd15379    5 LVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDyWPFGDFTCRLVRFQFYTNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAK-IINVCNWILSSAIGLPVMFMATTKYRQGSIDCtLTFSHP---TWY 229
Cdd:cd15379   85 HGSILFLTCISVQRYLGICHPLASWHKKKGKKLTwLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVC-YDLSPParsTAY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WEnlLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLR-RITRMVLVVVAVFIVCWTPIHI----YVII 304
Cdd:cd15379  164 FP--YGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPGEKRgKAARMIIVVAAVFLISFLPFHYtktrYLQV 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 305 KALVTIPETTFQ--TVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15379  242 RSWDGGPCTTRQafAEAYKRTRPFASMNSVLDPILFYFTQSKFRP 286
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
71-347 6.28e-19

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 86.60  E-value: 6.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTA-TNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:cd15382    1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTfIMMPLEIGWAATVAWLAGDFLCRLMLFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRtpRNAKIINVCNWILSSAIGLPVMFM-------ATTKYRQgsidCTL 221
Cdd:cd15382   81 RAFGLYLSSFVLVCISLDRYFAILKPLRLSDAR--RRGRIMLAVAWVISFLCSIPQSFIfhveshpCVTWFSQ----CVT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 222 TFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRL----KSVRMLSGSKEKDRNLRRIT------------RMVL 285
Cdd:cd15382  155 FNFFPSHDHELAYNIFNMITMYALPLIIIVFCYSLILCEIsrksKEKKEDVSEKSSSVRLRRSSvgllerarsrtlKMTI 234
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550822324 286 VVVAVFIVCWTPIHIYVIikalvtipettfqtvsWHFCI----------------ALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15382  235 VIVLVFIICWTPYFIMSL----------------WYWFDresaskvdpriqkglfLFAVSNSCMNPIVYGYFSIDLRR 296
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
75-346 1.41e-18

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 85.15  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15378    5 TMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCtLTFSHPTWYWENLL 234
Cdd:cd15378   85 SSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKC-KDYASSGDATNSLI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 -KICVFIFAFIMPVLIITVCYGLMILRLKSvrmLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPET 313
Cdd:cd15378  164 ySLFLTVTGFLIPLCVMCFFYYKIALFLKN---RNRQLANATSFEKPLTLVILAVVIFSVLFTPYHVMRNVRIASRLDSI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 314 TFQTVSWHFCIA-------LGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15378  241 GVSECTLIIIKSlyivtrpIAFLNSVINPVFYFLMGDHFR 280
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
79-349 1.49e-18

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 85.34  E-value: 1.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSI 157
Cdd:cd15977    9 VIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLyILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 158 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP--VMF-MATTKYRQGSIDCTLTFSHPT----WYW 230
Cdd:cd15977   89 LSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPeaIAFdMVEIDYRGQTLLVCMLPMEQTssfmRFY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR--MLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15977  169 QDVKDWWLFGFYFCLPLACTGVFYTLMSCEMLSIKngMRIALNDHMKQRREVAKTVFCLVVIFALCWLPLHLSRILKKTI 248
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 309 TIPETTFQTVSWHFCIALGYT-------NSCLNPVLYAFLDENFKRCF 349
Cdd:cd15977  249 YDVKDPQRCELLSFLLVMDYTginmaslNSCINPVALYFVSRKFKNCF 296
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
79-352 1.90e-18

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 84.57  E-value: 1.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15305    9 IIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLvGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHptwywENLLKI 236
Cdd:cd15305   89 IMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQDDEKVFVNGTCVLND-----ENFVLI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 237 CVFIfAFIMPVLIITVCYGLMILRLKsvrmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV------TI 310
Cdd:cd15305  164 GSFV-AFFIPLIIMVITYCLTIQVLQ-------RQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCkeacdqKL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 311 PETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCFREF 352
Cdd:cd15305  236 MEELLNVFVW-----VGYVSSGINPLVYTLFNKTYRRAFSNY 272
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
75-347 3.73e-18

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 83.97  E-value: 3.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNM 153
Cdd:cd15148    5 VFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNnQWTLGPLLCKVVGNLFYMNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATtkyrqGSIDCTLTFSHPTWY---W 230
Cdd:cd15148   85 YISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVLTE-----KNEESTKCFQYKDRKnakG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENllkicvfIFAFIMpVLIITVCYGLMILRLKSV--RMLSGSKEKDR-----NLRRITRMVLVVVAVFIVCWTPIH---I 300
Cdd:cd15148  160 KA-------IFNFLI-VAMFWLVFLLLILSYGKIakKLLRISRDKPDfpnaaKYNRTARKSFFVLFIFTVCFVPYHafrI 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 301 YVIIKALVTIPETTFQTVswHFC----IALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15148  232 FYITSQLQNNSCYWKEIL--HKTneimLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
71-350 4.57e-18

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 83.46  E-value: 4.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15299    4 VLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADlIIGVISMNLFTTYIIMNRWALGNLACDLWLSID 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMatTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15299   84 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILF--WQYFVGKRTVPPDECFIQFL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYglmilrLKSVRMLSGSKEKDRNLRRItrmvlvvVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15299  162 SEPIITFGTAIAAFYLPVTIMTILY------WRIYKETIKEKKAAQTLSAI-------LLAFIITWTPYNIMVLVNTFCD 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 310 --IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCFR 350
Cdd:cd15299  229 scIPKTYWNLGYW-----LCYINSTVNPVCYALCNKTFRTTFK 266
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
79-347 5.02e-18

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 83.76  E-value: 5.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLF----GNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15318    5 LACAIGMLiivlGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTvLPFSTIRSVESCWYFGDSFCRLHTCLDTLFC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI--------DCTLTFSH 225
Cdd:cd15318   85 LTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAELltsvpcvgSCQLLYNK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 pTWYWENLLkicvfifAFIMPVLIITVCYG-LMILRLKSVRM----LSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI 300
Cdd:cd15318  165 -LWGWLNFP-------VFFIPCLIMIGLYVkIFIVAKRQARAiaslLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 301 YVIIKALVTI--PETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15318  237 DTMVDSLLNFitPPLLFDIIIW-----FAYFNSACNPLIYVFSYPWFRK 280
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
76-348 5.95e-18

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 83.34  E-value: 5.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPfGTILCKIVISIDYYNMFT 155
Cdd:cd15171    6 LCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSL-GNPTCKVLVALSSVGLHS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKII-NVCNWILSSAIGLP-VMFMATTKYRQGSiDCtlTFSHPTW----- 228
Cdd:cd15171   85 EALFNVLLTVQASRVFFHGRLASSARRVAPCGIIaSVLAWLTAFLVTLPeFVFYKPQMDSQKS-KC--AFSRPHFlpaee 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 -YWENLLKICVFIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKDRNlRRITRMVLVVVAVFIVCWTPIHIYVIIKA- 306
Cdd:cd15171  162 tFWKYFLTLKMNIVVLVFPLLVFIICC---------VQLRKTQRFRERQ-RDLSKLVFAIMVVFLLMWAPYNIALFLSAf 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 307 -----LVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15171  232 kehfsLRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRR 278
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
79-349 8.06e-18

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 83.34  E-value: 8.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPF-----GTILCKIVISIDYYN 152
Cdd:cd15128    9 LIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLyIVIDLPINVYKLLAMDWPFgdqpfGQFLCKLVPFIQKAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF---MATTKYRQGSIDCTLTFSHPTW- 228
Cdd:cd15128   89 VGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIgfdMVRFNYKGVTLRTCLLRPETSFm 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 -YWENLLKICVFIFAFIMPVLIITVCYGLM---ILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15128  169 kFYIDVKDWWLFGFYFCLPLVCTAIFYTLMtceMLRKRNGMLRIALNEHLKQRREVAKTVFCLVVIFALCWLPLHLSRIL 248
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 305 KALVTIPET-------TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15128  249 KLTVYDQNDpnrcellSFLLVLDYFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
71-349 8.46e-18

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 83.36  E-value: 8.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMK---TATNIYIFNLALADALATS-TLPFQSVNYLM--GTWPFGTILCKi 144
Cdd:cd15355    1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLQhlqSTVHYHLASLALSDLLILLlAMPVELYNFIWvhHPWAFGDAACR- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 145 visiDYYNM-----FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ----G 215
Cdd:cd15355   80 ----GYYFLrdactYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTMGEQNRSgthpG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 216 SIDCTLTFSHPTwyWENLLKICVFIfAFIMPVLIITVCYGLMILRLKSV-----------------RMLSGSKEKDR--N 276
Cdd:cd15355  156 GLICTPIVDTST--LKVVIQVNAFL-SFLFPMLVISVLNTLIANQLTVMvnqaeqenqvctiggqrTVLSVSMEPGRvqS 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550822324 277 LRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE-TTFQTVSWHFCI----ALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15355  233 LRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYVSDEQwTTFLYDFYHYFYmltnVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
75-349 8.62e-18

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 83.47  E-value: 8.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKT-ATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTiLCKIVISIDYYN 152
Cdd:cd15319    5 CLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFvALLVMPWKAVAEVAGYWPFGA-FCDVWVAFDIMC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVM--FMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15319   84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISfIPVQlnWHKDSGDDWVGLHNSSISRQVEEN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLK----ICVFIFAFIMPVLIITVCYG-------LMILRLKSVRMLSGSKEKDRNLR-----------------RIT 281
Cdd:cd15319  164 CDSSLNrtyaISSSLISFYIPVAIMIVTYTriyriaqIQIRRISSLERAAEHAQSCRSNRidchhhtslrtsikketKVL 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 282 RMVLVVVAVFIVCWTPIHIYVII------------KALVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFlDENFKRCF 349
Cdd:cd15319  244 KTLSVIMGVFVCCWLPFFILNCMvpfcdrppadpdAGLPCVSETTFDVFVW-----FGWANSSLNPIIYAF-NADFRKVF 317
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
71-347 8.87e-18

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 82.90  E-value: 8.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVnYLMGT--WPFGTILCKIVISI 148
Cdd:cd15364    1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTI-YVSNNhkWPWGSLACKITGYI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIINVCNWILSSAIGL---PVmFMATTKYRQGSIDCTLTFSH 225
Cdd:cd15364   80 FFCNIYISILLLCCISIDRFVAV---VYALESRGRRRQRIAAFISFLIFIVVGLvhsPV-FIMREGQTEGSHTCFETLQM 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTwywenllKICVFIFAfimpVLIITVCYGLMILRLKSVRMLSGSKEKD----RNLRRITRMVLVVVAVFIVCWTPIHIY 301
Cdd:cd15364  156 DT-------QVAGFYYA----RFCIGFAIPLAILIFTNYRIFRSIQTSTsltpHQKAKVKYLAIAVIVIFLICFAPYHLV 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822324 302 VIIKALVTIP--------ETTFQTVSWHFcIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15364  225 LLVRAIAFSLypngmcgfEERIYTPSVIF-LCLSTVNSVADPIIYVLVSENVRQ 277
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
74-347 9.33e-18

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 82.67  E-value: 9.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT--STLP---------FQSvnylmgtwpfGTILC 142
Cdd:cd15196    4 IAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlfNVLPqliwdityrFYG----------GDLLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 143 KIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIINVCNWILSSAIGLPVMFMAT-TKYRQGSIDCTL 221
Cdd:cd15196   74 RLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLFIFSyQEVGSGVYDCWA 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 222 TFSHPtwyWENLLKICVFIFA-FIMPVLIITVCYGLMIL-----RLKSVrmlsgskekdrnlrritRMVLVVVAVFIVCW 295
Cdd:cd15196  153 TFEPP---WGLRAYITWFTVAvFVVPLIILAFCYGRICYvvwraKIKTV-----------------KLTLVVVACYIVCW 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 296 TPIHIYVIIKALVtiPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15196  213 TPFFVVQMWAAWD--PTAPIEGPAFVIIMLLASLNSCTNPWIYLAFSGNLRR 262
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
76-349 9.96e-18

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 82.67  E-value: 9.96e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYNM 153
Cdd:cd15304    6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLlGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDF--RTPRNAKIINVcnWILSSAIGLPVMFMA----TTKYRQGSidCTLTFshpt 227
Cdd:cd15304   86 TASIMHLCAISLDRYIAIRNPIHHSRFnsRTKAFLKIIAV--WTISVGISMPIPVFGlqddSKVFKEGS--CLLAD---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 wywENLLKICVFIfAFIMPVLIITVCYGLMILRLksvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIkAL 307
Cdd:cd15304  158 ---ENFVLIGSFV-AFFIPLTIMVITYFLTIKSL---------QQSISNEQKASKVLGIVFFLFVVMWCPFFITNVM-AV 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 308 VTIPETTFQTVS--WHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15304  224 ICKESCNEVVIGglLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
73-349 1.23e-17

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 81.89  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15335    3 IVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLvAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWywe 231
Cdd:cd15335   83 CCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQHDHVIY--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 nllKICVFIFAFIMPVLIITVCYglmilrlksVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTPihiYVIIKALVTIP 311
Cdd:cd15335  160 ---TIYSTFGAFYIPLTLILILY---------YRIYHAASRE----RKAARILGLILGAFILSWLP---FFIKELIVGLS 220
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822324 312 ETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15335  221 VMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
75-349 1.31e-17

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 82.54  E-value: 1.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSV------NYLMGTWpfGTILCKIVISi 148
Cdd:cd15082   18 ALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFltnargYFFLGVW--ACVLEGFAVT- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 dyYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCnWILSSAIGLPVMfMATTKYRQGSIDCTltfSHPTW 228
Cdd:cd15082   95 --FFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFV-WTFSFIWTIPPV-LGWSSYTVSKIGTT---CEPNW 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENL----LKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNL-RRITRMVLVVVAVFIVCWTPIHIY-V 302
Cdd:cd15082  168 YSGNMhdhtYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGRLGNARKPeRQVTRMVVVMIVAFMVCWTPYAAFsI 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 303 IIKALVTIP-ETTFQTVSWHFcialGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15082  248 LVTAHPTIHlDPRLAAIPAFF----SKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
78-349 1.32e-17

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 83.13  E-value: 1.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  78 SIVCVVGLFGNFLVMYVIVRYTKMKT-ATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTiLCKIVISIDYYNMFT 155
Cdd:cd15320    9 SVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLvAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMF----MATTKYRQGSIDC-TLTFSHPTWY 229
Cdd:cd15320   88 SILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfIPVQLnwhkAKPTSFLDLNASLrDLTMDNCDSS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITVCYgLMILRL--KSVRMLSG----------------------SKEKDRNLR------- 278
Cdd:cd15320  168 LNRTYAISSSLISFYIPVAIMIVTY-TRIYRIaqKQIRRISAleraavhakncqnstgnrgsgdCQQPESSFKmsfkret 246
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550822324 279 RITRMVLVVVAVFIVCWTPIHIYVII--------KALVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFlDENFKRCF 349
Cdd:cd15320  247 KVLKTLSVIMGVFVCCWLPFFILNCMvpfckptsTEPFCISSTTFDVFVW-----FGWANSSLNPIIYAF-NADFRKAF 319
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
73-349 1.41e-17

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 82.56  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15981    3 FILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLvGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPvkaldFR---TPRNAKIINVCNWILSSAIGLPVMFMAT-TKYRQGSIDCTLTFSHPT 227
Cdd:cd15981   83 SVSASVFTLVAIAVERFRCIVHP-----FRqklTLRKAIVTIVIIWVLALIIMCPSAVTLTvTREEHHFMVDDYNNSYPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WY-WEN--------LLKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITR-------MVLVVVAV 290
Cdd:cd15981  158 YScWEAwpdtemrkIYTTVLFSHIYLAPLTLIVIMYARIAFKLfKSSAPIRGSQGEEEEGRRVSKrkikvinMLIIVALF 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550822324 291 FIVCWTPIHIYVIIKALVTIPETTFQTVSWH---FCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15981  238 FTLSWLPLWTLMLLTDYGHLSEDQLNLVTVYvfpFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
73-338 1.48e-17

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 82.64  E-value: 1.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVvglFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15958    6 LMALIVLLIV---AGNVLVIVAIGRTQRLQTLTNLFITSLACADlVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd15958   83 CVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSfLPIMMHWWRDEDDQALKCYEDPGCCDFVT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVFIFAFIMPVLIITVCYGLMIL--------------RLKSVRMLSGSKEKDRNLR-------RITRMVLVVVA 289
Cdd:cd15958  163 NRAYAIASSIISFYIPLLIMIFVYLRVYReakkqikkidkcegRFHNTLTGLGRKCKRRPSRilalreqKALKTLGIIMG 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 290 VFIVCWTPIHIYVIIKALVT--IPETTFQTVSWhfciaLGYTNSCLNPVLY 338
Cdd:cd15958  243 VFTLCWLPFFLVNVVNVFNRelVPDWLFVFFNW-----LGYANSAFNPIIY 288
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
71-350 1.58e-17

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 81.92  E-value: 1.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15334    1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLvAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSiDCTLTFSHPTWy 229
Cdd:cd15334   81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSRED-ECIIKHDHIVF- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 wenllKICVFIFAFIMPVLIItvcyglMILRLKSVRMLSGSKEKDRNLRRItrmvlvvVAVFIVCWTPihiYVIIKALVT 309
Cdd:cd15334  159 -----TIYSTFGAFYIPLALI------LILYYKIYRAATRERKAATTLGLI-------LGAFVICWLP---FFVKEVIVN 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 550822324 310 IPETTFQTVSW-HFCIALGYTNSCLNPVLYAFLDENFKRCFR 350
Cdd:cd15334  218 TCDSCYISEEMsNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
69-349 1.69e-17

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 82.22  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  69 TAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT---STLPFqsVNYLMGTWPFGTILCKIV 145
Cdd:cd15084    9 TYLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTlfgSSVSF--SNNIVGFFVFGKTMCEFE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 146 ISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTpRNAKIINVCNWILSSAIGLPVMFMATTKYRQGsidcTLTFSH 225
Cdd:cd15084   87 GFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQ-RHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEG----LRTSCG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYW----ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKE-KDRNLRRITRMVLVVVAVFIVCWTPIHI 300
Cdd:cd15084  162 PNWYTggtnNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESEtTQRAEKEVTRMVIAMVMAFLICWLPYAT 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 301 YVIIKAlvTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15084  242 FAMVVA--TNKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCL 288
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
72-347 1.96e-17

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 81.71  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVC-VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15073    1 NIVAAYLIVAgIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDlGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPvKALDFRTPRNAKIINVCNWILSSA-IGLPVMFMATTKYRQGSIDCTLTFSHPTW 228
Cdd:cd15073   81 IFFGMASIGLLTVVAVDRYLTICRP-DLGRKMTTNTYTVMILLAWTNAFFwAAMPLVGWASYALDPTGATCTINWRKNDS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSV---RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd15073  160 SFVSYT-MSVIVVNFIVPLAVMFYCYYNVSRFVKKVlasDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWA 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 306 AL---VTIPettfqtvSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15073  239 SFgepKKIP-------PWMAIIPplFAKSSTFYNPCIYVIANKKFRR 278
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
75-348 2.21e-17

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 81.67  E-value: 2.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIV-RYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDYYN 152
Cdd:cd15376    5 PILGVEFLVAVLGNGLALWLFVtRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPkNWRFGEAACKLERFLFTCN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGS-IDCTLTFSHPTWYwe 231
Cdd:cd15376   85 LYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVERHNkTECLGTAVDSRLP-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAF--IMPVLIITVCYGLMI---LRLKSVRMLsgskEKdrnlRRITRMvlvvvavfivcwtpIHIYVIIKA 306
Cdd:cd15376  163 TYLPYSLFLAVVgcGLPFLLTLASYLAIVwavLRSPGITTL----EK----RKVAAL--------------VAVVVALYA 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550822324 307 LVTIPETTFQTV------SWHFC-----IALGYT--------NSCLNPVLYAFLDENFKRC 348
Cdd:cd15376  221 VSFVPYHILRNLnlyrrlQWLKAaaslrIYFAYQvtkglvtlNMCIHPLLYMAVADSIRLC 281
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
76-346 2.43e-17

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 81.41  E-value: 2.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCV-VGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNyLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd14989    5 LYTIFLFpIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFN-LNEKYYDIAVLCTFMSLFLQINMY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILS-SAIGLPVmfmaTTKYRQGSIDCTLTFSH-PTWYWen 232
Cdd:cd14989   84 SSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASiSATLLPF----TAVQAQHTGEVHFCFADvREIQW-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 lLKICVfifAFIMPVLIITVCYGLMilrlksVRMLSGSkEKDRNLR----RITRMVLVVVAVFIVCWTPIHIYVIIKAL- 307
Cdd:cd14989  158 -LEVTL---GFIIPFSIIGLCYSLI------VRVLVRA-QKHRRLRprrqKALRMILVVVLVFFICWLPENVFISIQLLq 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 308 -VTIPETTFQTVSWHFCIALG-------YTNSCLNPVLYAFLDENFK 346
Cdd:cd14989  227 gTQEPSESYDESFRHNHPLTGhivnlaaFSNSCLNPLIYSFLGETFR 273
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
76-347 3.12e-17

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 81.40  E-value: 3.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRyTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15150    6 LYTVLFIVGLTMNGLAMRVFFQ-IPSKSNFIIFLKNTVISDLLMILTFPFKILsDAKLGSWPLRGFVCQVTSVIFYFTMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI-DCTLTFSHPTWYWENL 233
Cdd:cd15150   85 ISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQPTPKNVkKCSLLKSEFGLVWHEI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LK-ICVFIFAFIMpvLIITVCYGLMILRL-KSVRMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHiyviikaLVTIP 311
Cdd:cd15150  165 VNyICQVIFWVNF--LIVIVCYTLITKELyKSYKRTRGVGKVSR--KKVNVKVFIIIAVFFICFVPFH-------FARIP 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 312 ETTFQTVSWHFCIA-------------LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15150  234 YTLSQTRDVFDCTAkntlfyvkestlwLTSLNACLDPFIYFFLCKSFRN 282
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
77-347 3.15e-17

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 81.42  E-value: 3.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15396    7 YSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMcIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVcnWILSSAIGLPVMF---MATTKYRQGSIDCTLTFSH------- 225
Cdd:cd15396   87 SIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLI--WLFSLMISIPFLIfhqLTDEPFRNLSSHSDFYKDKvvcieaw 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR-MLSGSKEKDRNL---RRITRMVLVVVAVFIVCWTPIHIY 301
Cdd:cd15396  165 PSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNsKIDRMRENESRLsenKRINTMLISIVVTFAACWLPLNIF 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 302 -VIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15396  245 nVVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
71-349 3.32e-17

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 81.15  E-value: 3.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNI---YIFNLALADALAT-STLPFQSVNYLM--GTWPFGTILCKI 144
Cdd:cd15130    1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTvryHLGSLALSDLLILlLAMPVELYNFIWvhHPWAFGDAGCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 145 VISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ------GSID 218
Cdd:cd15130   81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESddgthpGGLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 219 CTLTFSHPTwyWENLLKICVFIfAFIMPVLIITVCYGLMILRLKsvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPI 298
Cdd:cd15130  161 CTPIVDTAT--LKVVIQVNTFM-SFLFPMLVTSILNTVIANKLV------------QALRRGVLVLRAVVIAFVVCWLPY 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 299 HIYVIIKALV-----TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15130  226 HVRRLMFCYIsdeqwTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
74-348 3.33e-17

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 81.36  E-value: 3.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATStlpFQSVNYLM----GTWPFGTILCKIVISID 149
Cdd:cd15388    4 IAVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAF---FQVLPQLVwditDRFRGPDVLCRLVKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKAldFRTPRNAKIINVC-NWILSSAIGLPVMFM-ATTKYRQGSIDCTLTFSHP- 226
Cdd:cd15388   81 VVGMFASSYMIVAMTFDRHQAICRPMVT--FQKGRARWNGPVCvAWAISLILSLPQVFIfSKVEVAPGVYECWACFIEPw 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 ------TWywenllkicVFIFAFIMPVLIITVCYGL------MILRLKSVRMLSGSKEKDRNLRRIT------------- 281
Cdd:cd15388  159 glkayvTW---------ITLVVFVLPTLIITVCQVLifkeihINIYLKSQIIVAVVKKKQLLSSRASsvaevskamiktv 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550822324 282 RMVLVVVAVFIVCWTPihIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15388  230 KMTLVIVLVYVLCWAP--FFLVQLWSVWDPKAPTEGATFTILMLLASLNSCTNPWIYMAFSSSVSKE 294
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
71-348 3.46e-17

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 80.98  E-value: 3.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADalatstlpfqsvnylMGTWPFGTILCKIVISIDY 150
Cdd:cd15075    1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVAD---------------LGTTVFGGLLSVVTNAVGY 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNM-------------FTSIFTLCT---MSVDRYIAVCHPVKALDFrTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ 214
Cdd:cd15075   66 FNLgrvgcvlegfavaFFGIAALCTvavIAVDRLFVVCKPLGTLTF-QTRHALAGIASSWLWSLIWNTPPLFGWGSYQLE 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 215 GsidcTLTFSHPTWYWENLLK----ICVFIFAFIMPVLIITVCYGLMILRLKSVRML----SGSKEKDRNlrRITRMVLV 286
Cdd:cd15075  145 G----VMTSCAPDWYSRDPVNvsyiLCYFSFCFAIPFAIILVSYGYLLWTLRQVAKLgvaeGGSTAKAEV--QVARMVVV 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550822324 287 VVAVFIVCWTPIHIYVIIkaLVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15075  219 MVMAFLLCWLPYAAFALT--VVSKPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFRDC 278
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
71-347 4.43e-17

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 81.06  E-value: 4.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15316    1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTvMPFSTVRSVESCWYFGESFCTFHTCCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHP-VKALDFRTPRNAKIINVcNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTW 228
Cdd:cd15316   81 VSFCYASLFHLCFISVDRYIAVTDPlVYPTKFTVSVSGICISV-SWIFSLTYSFSVFYTGVNDDGLEELVNALNCVGGCQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLK-SVRML---------SGSKEKDRNLRR---ITRMVLVVVAVFIVCW 295
Cdd:cd15316  160 IILNQNWVLVDFLLFFIPTFAMIILYGKIFLVAKqQARKIemtsskaesSSESYKDRVARRerkAAKTLGITVIAFLVSW 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822324 296 TPIHIYVIIKALVT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15316  240 LPYLIDVLIDAFMNfiTPPYIYEICCW-----CAYYNSAMNPLIYALFYPWFRK 288
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
74-257 6.97e-17

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 79.89  E-value: 6.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYYN 152
Cdd:cd15215    3 SVLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVlVMPWVIATSVPLFWPLDSHLCTALVVLMHLF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF-MATTKYRQGSIDCTLTFSHPTWYwe 231
Cdd:cd15215   83 AFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYgWGQAAFDERNALCSVIWGSSYSY-- 160
                        170       180
                 ....*....|....*....|....*.
gi 550822324 232 nllKICVFIFAFIMPVLIITVCYGLM 257
Cdd:cd15215  161 ---TILSVVSSFVLPVIIMLACYSMV 183
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
76-349 7.88e-17

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 79.69  E-value: 7.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15309    6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLvATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHP-VKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFShptwywenl 233
Cdd:cd15309   86 ASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQNECIIANPAFV--------- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 lkICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKALVT--IP 311
Cdd:cd15309  157 --VYSSIVSFYVPFIVTLLVYVQIYIVLQ--------KEK-----KATQMLAIVLGVFIICWLPFFITHILNMHCDcnIP 221
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822324 312 ETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15309  222 PALYSAFTW-----LGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
72-347 2.20e-16

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 78.66  E-value: 2.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISIDY 150
Cdd:cd15200    2 FLAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNeVWRFGATACQVNLFMLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMfmaTTKYRQGSIDCtLTFSHPT--- 227
Cdd:cd15200   82 MNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLL---LLDHVQSNSTC-LSYDHGTdps 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 --WYWENLLkicvFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKekdrnLRRITRMVLVVVAVFIVCWTPIHIY---V 302
Cdd:cd15200  158 asDRWHRIL----FFLEFFLPLGIILFCIFSIILTLKQRKLAKQAG-----PQRAVKVLAVIVLVYTVCFLPSILFalaS 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 303 IIKALVTIPET-TFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15200  229 LVAFKVSQCRSlDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLN 274
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
71-346 2.41e-16

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 78.66  E-value: 2.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISID 149
Cdd:cd14988    1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDyTWLWGSFLCKFTHYFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP-VMFMATTKYRQ-GSIDCTLTFSHPT 227
Cdd:cd14988   81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPeVVHMQLLDGVEpMCLFLAPFETYDE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWEnlLKICVFIFAFIMPVLIITVCYGLMILRLKSvrmlSGSKEKdrnlRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd14988  161 WALA--VSLLTLIIGFLIPFSIIAVFNVLTARYIRT----AGRPES----RRHCLLIYAYILVFVVCWLPYHVTLLLLTL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 308 VTIPeTTFQTVSWHF---------CIALgyTNSCLNPVLYAFLDENFK 346
Cdd:cd14988  231 HGSH-ISLHCNLVHFlyffydvidCFSL--LHCVANPILYNFLSKSFR 275
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
73-352 4.08e-16

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 77.95  E-value: 4.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGlfGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLM-GTWPFGTILCKIVISIDY 150
Cdd:cd15306    5 LLILMVIIPTIG--GNILVILAVSLEKKLQYATNYFLMSLAVADLLvGLFVMPIALLTILFeAMWPLPLVLCPIWLFLDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYW 230
Cdd:cd15306   83 LFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLKICVfifAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV-T 309
Cdd:cd15306  163 FILFGSLA---AFFTPLAIMIVTYFLTIHALR--------KQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCdS 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 310 IPETTFQTVSWHFcIALGYTNSCLNPVLYAFLDENFKRCFREF 352
Cdd:cd15306  232 CNQTTLQMLMEIF-VWIGYVSSGVNPLVYTLFNKTFRDAFGRY 273
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
88-348 4.43e-16

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 77.95  E-value: 4.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  88 NFLVMYVIVRYTKMKTATNIYIFNLALADALAT---STLPFQSVNYLMGTWpfGTILCKIVISIDYYNMFTSIFTLCTMS 164
Cdd:cd15077   18 NVLTIICTIKYKKLRSHLNYILVNLAVANLIVVcfgSTTAFYSFSQMYFVL--GPLACKIEGFTATLGGMVSLWSLAVVA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 165 VDRYIAVCHPVKALDFRTPrNAKIINVCNWILSSAIGLPVMFmATTKYRQGSIDCTLTfshPTWY-----WEN-LLKICV 238
Cdd:cd15077   96 FERFLVICKPLGNFTFRGT-HAIIGCIATWVFGLAASLPPLF-GWSRYIPEGLQCSCG---PDWYttnnkWNNeSYVMFL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 239 FIFAFIMPVLIITVCYGLMILRLKSV-RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIikALVTIPETTFQT 317
Cdd:cd15077  171 FCFCFGVPLSIIVFSYGRLLLTLRAVaKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFAL--WVVTNRGEPFDL 248
                        250       260       270
                 ....*....|....*....|....*....|.
gi 550822324 318 VSWHFCIALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15077  249 RLASIPSVFSKASTVYNPVIYVFMNKQFRSC 279
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
73-338 4.50e-16

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 77.91  E-value: 4.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMGT-WPFGTILCKIVISIDYY 151
Cdd:cd15371    3 IPAVYIIVVVLGVPSNAIILWMLFFRLR-SVCTAIFYANLAISDLLFCITLPFKIVYHLNGNnWVFGETMCRIITITFYG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPT---- 227
Cdd:cd15371   82 NMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYYLKELNITTCHDVLPEceqn 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WYWENLLKICVFIFAFIMPVLIITVCYGLMIlrlksvRMLSGSKEKDRNLRRITRMvlvVVAVFIVCWTPIHIYVIIKAl 307
Cdd:cd15371  162 SNFQFYYFISMAVFGFLIPLVITIFCYISII------RTLNAYEHKWFWYVKITAL---VLIIFTICFAPSNVILIIHH- 231
                        250       260       270
                 ....*....|....*....|....*....|...
gi 550822324 308 VTIPETTFQTVSWHFCIA--LGYTNSCLNPVLY 338
Cdd:cd15371  232 FNYYYFNNDNLYSIYLIAlcLGSLNSCLDPFLY 264
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
82-348 1.82e-15

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 76.04  E-value: 1.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD---ALATSTLpFQSVNYlMGTWPFGTILCKIV-ISIDYYNMfTSI 157
Cdd:cd15085   12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDlmmALCGTTI-VTVTNY-EGYFYLGDAFCIFQgFAVNYFGI-VSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 158 FTLCTMSVDRYIAVCHPVKALDFRTPRNAKIInVCNWILSSAIGLPVMFMATTKYRQG-SIDCTLTFSHPTWYWENLLkI 236
Cdd:cd15085   89 WSLTLLAYERYNVVCKPMGGLKLSTKRGYQGL-LFIWLFCLFWAVAPLFGWSSYGPEGvQTSCSIGWEERSWSNYSYL-I 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 237 CVFIFAFIMPVLIITVCYGLMILRL----KSVRMLSGsKEKDRNLRRITRMVLVVVAVFIVCWTPihiYVIIKALVTI-P 311
Cdd:cd15085  167 LYFLMCFVIPVAIIGFSYGNVLRSLhklnKKIEQQGG-KNCPEEEERAVIMVLAMVIAFLICWLP---YTVFALIVVVnP 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 550822324 312 ETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15085  243 ELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFRES 279
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
71-353 2.01e-15

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 75.63  E-value: 2.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15295    1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAiSIPLYIPYTLTNRWDFGRGLCVFWLVID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHpvkALDFRTPRNAK----IINVCNWILSSAIGLPvMFMATTKYRQGSIDCTltfsh 225
Cdd:cd15295   81 YLLCTASVYNIVLISYDRYQSVSN---AVSYRNQQTATlrivTQMVAVWVLAFLVHGP-AILVSDSWKTEDGECE----- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWENLLKICVFIFAFIMPVLIITVcYGLMILRlksvrmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIK 305
Cdd:cd15295  152 PEFFSNWYILAITSVLEFLVPVILVAY-FNTQIYW---------SLWKRLRDRKLAKSLAIILGTFAICWAPYSLFTIIR 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 306 ALVtipETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE-FC 353
Cdd:cd15295  222 AAC---EKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKiFC 267
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
76-346 2.34e-15

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 75.95  E-value: 2.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-MGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15167    6 FYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLgIAPWKLKIFHCQVTACLIYINMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ----GSIDCTLTFSHptwYW 230
Cdd:cd15167   86 LSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEkpgvGCADFKTEFGR---HW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLK-ICVFIFAFIMPVLIITVCygLMILRLKSVRmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIyviikalVT 309
Cdd:cd15167  163 HVLTNfICMAIFLNFSAIILISNF--LVIRKLYRNK----DSEEYRNARQALVNILLVTAGYVICFVPYHI-------VR 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 550822324 310 IPETTFQTVSWHFC-------------IALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15167  230 IPYTLSQSEVITDCslkrslflakestLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
74-340 3.90e-15

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 75.63  E-value: 3.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 152
Cdd:cd15385    4 IAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADlVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIInVCNWILSSAIGLPVMFMATTKYRQ---GSIDCTLTFSHPTWY 229
Cdd:cd15385   84 MFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMI-GSAWALSFILSTPQYFIFSLSEIEngsGVYDCWANFIVPWGI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIfaFIMPVLIITVCYGLMI------LRLKSVRMLSGSKEKDRNLR--------------RITRMVLVVVA 289
Cdd:cd15385  163 KAYITWITISI--FVVPVIILLTCYGFICyniwrnIKCKTRRGLSDNALKNILLAvcvssvktisrakiRTVKMTFVIVL 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 290 VFIVCWTPihiYVIIKALVTIPETTFQTVSWHFCIA----LGYTNSCLNPVLYAF 340
Cdd:cd15385  241 AYIVCWAP---FFTIQMWSVWDQNFPWDESENTAVTitalLASLNSCCNPWIYMF 292
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
82-348 5.37e-15

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 74.87  E-value: 5.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-----TSTLpFQSVNylmGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15080   12 LLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMvfggfTTTM-YTSMH---GYFVFGPTGCNLEGFFATLGGEIA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIINVC-NWILSSAIGLPVMFmATTKYRQGSIDCTLTFS----HPTWYWE 231
Cdd:cd15080   88 LWSLVVLAIERYVVVCKPMS--NFRFGENHAIMGVAfTWVMALACAAPPLV-GWSRYIPEGMQCSCGIDyytlKPEVNNE 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLkICVFIFAFIMPVLIITVCYGLMILRLK-SVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPihiYVIIKALVTI 310
Cdd:cd15080  165 SFV-IYMFVVHFTIPLIVIFFCYGRLVCTVKeAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVP---YASVAFYIFT 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 311 PE-----TTFQTVSWHFcialGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15080  241 HQgsdfgPIFMTIPAFF----AKSSAVYNPVIYILMNKQFRNC 279
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
75-349 1.02e-14

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 74.13  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYT---KMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWP--FGTILCKIVISI 148
Cdd:cd15356    5 AVYALIWALGAAGNALTIHLVLKKRslrGLQGTVHYHLVSLALSDLLIlLISVPIELYNFVWFHYPwvFGDLVCRGYYFV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSID---------C 219
Cdd:cd15356   85 RDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFIMGQKYELETADgepepssrvC 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 220 TLTFSHPTwyWENLLKICVFIfAFIMPVLIITVCYGLMILRLKSvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPIH 299
Cdd:cd15356  165 TVLVSRAT--LKVFIQVNAFV-SFVLPLALIAFLNGVTVSHLRI-----------QSLQHSVQVLRAIVIAYVICWLPYH 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 300 IYVIIKALV-----TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15356  231 ARRLMFCYVpddawTDSLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
79-349 1.20e-14

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 73.81  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIY-IFNLALADAL--------ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd14980    9 IIGILALIGNILVIIWHISSKKKKKKVPKLlIINLAIADFLmgiylliiAIADQYYRGRYAQYSEEWLRSPPCLLACFLV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIINVCNWILSSA-IGLPVMFmattKYRQGSIDCTLTFSH--- 225
Cdd:cd14980   89 SLSSLMSVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIfAAIPILY----SINQPGDNRLYGYSSicm 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 PTWYWENLLKICVFIFAFIMPV--LIITVCYGLMILRLKSVRMLSGSKEKDRNlRRITRMVLVVVAVFIVCWTPIhIYVI 303
Cdd:cd14980  164 PSNVSNPYYRGWLIAYLLLTFIawIIICILYILIFISVRKSRKSARRSSSKRD-KRIAIRLALILITDLICWLPY-YIVI 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 550822324 304 IKALVTIPETTFQTVSWHFCIALGyTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14980  242 FSGLLTSTEIDIHVLQFIAILALP-LNSAINPYLYTLTTPTFKRDF 286
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
71-347 1.81e-14

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 73.29  E-value: 1.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYvIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTWPFGTILCKIVISID 149
Cdd:cd15969    1 IVFPVLYLIIFIGSILLNGLAVW-IFFHIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQdSGLGPWNFNFFLCRYTSVLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHPTW 228
Cdd:cd15969   80 YASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPnIILTNGQPTEDNIHDCSKLKSPLGV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLK-ICVFIFAFIMPVLIitVCYgLMILRL--KSVRMLSGSKEKDRNLRRITRmvlVVVAVFIVCWTPIH---IYV 302
Cdd:cd15969  160 KWHTAVSyINICIFVAVLVILI--VCY-ISISRYiyKSSKQFISSSSRTRKHNQSIR---VVVAVFFVCFLPYHlcrIPF 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 303 IIKALVTIPETTFQTVSWhFC----IALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15969  234 TFSQLDKILDCTIKTILY-YCkeatLFLSACNVCLDPIIYFFMCRSFSQ 281
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
76-347 1.87e-14

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 72.94  E-value: 1.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15008    5 VFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLlSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPvkaLDFRTPR-NAKIINVCNWILSSAIGLPVMFMattkYRQGSIDCTLTFSHPTWYwENL 233
Cdd:cd15008   85 VQIYVLLSICVDRFYTIVYP---LSFKVSReKAKKMIAASWLFDAAFVSPALFF----YGSNWGPHCNFFLPDSWD-GAA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGlmilrlKSVRMLSGSKEKDRNLRRIT-----------RMVLVVVAVFIVCWTPIHIYV 302
Cdd:cd15008  157 YAIIHLLVGFLVPSILIILFYQ------KVIKYIWRIGTDGRTVRRTMnivprtkvktiKMFLMLNSMFLLSWLPFYVVQ 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 303 IIKALVTIPETT---FQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15008  231 LWHPRESDYRQSslvFLAVTW-----ISFSSSASKPTLYSVYNANFRR 273
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
79-349 2.97e-14

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 72.46  E-value: 2.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGTILCKivisidYYNMFTSI 157
Cdd:cd15086    9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVcVLGTPFSFAASTQGRWLIGEHGCR------WYGFANSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 158 F------TLCTMSVDRYIAVCHPVKAlDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQG-----SIDCTLTFSHP 226
Cdd:cd15086   83 FgivsliSLAVLSYERYCTLLRPTEA-DVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGpgttcSVQWTSRSANS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TWYwenllKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNlRRITRMVLVVVAVFIVCWTPihiYVIIKA 306
Cdd:cd15086  162 ISY-----IICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKINKSTARKRE-QHVLLMVVTMVICYLLCWLP---YGVMAL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 307 LVTIPETTFQTVSWHFCIA-LGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15086  233 LATFGKPGLVTPVASIVPSiLAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
73-346 3.06e-14

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 72.57  E-value: 3.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15149    3 IPVFYSLVFIVGILLNGVNFWIFF-YVPSNKSFIVYLKNIVFADLLMSLTFPFKILsDVELGPWQLNVIVCRYSAVIFYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ-GSIDCTLTFSHPTWYW 230
Cdd:cd15149   82 NMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHEaNYTKCARLKSELGIQW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ENLLK-ICVFIFAFIMPVLII---TVCYGLMILRLKSVRMLSGSKEKdrnlrrITRMVLVVVAVFIVCWTPIHIyviika 306
Cdd:cd15149  162 HKASNyICVSIFWVVFLLLIIfyvAISRKIYKSNQKFRRNSTNMKAK------SSRNIFSILFVFFVCFVPYHA------ 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822324 307 lVTIPETTFQTVSWHFC-------------IALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15149  230 -LRIPYTLSQTGADYSCqsktilyymkeftLLLSAANVCLDPIIYFFLCQPFR 281
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
71-254 5.23e-14

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 71.91  E-value: 5.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMK-TATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVISI 148
Cdd:cd15170    1 WLVLAVYIITFLIGLPANLLAFYTFIRKVRRKpTPIDILLLNLTVSDLIFLLFLPFKMAEAASGmIWPLPYFLCPLSSFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSA---IGLPVMFMATTKYRQG--SIDCTLTF 223
Cdd:cd15170   81 FFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFShcsIVYIVEYHIDSENTSVtnNSRCYDNF 160
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 550822324 224 ShptwywENLLKIC------VFIFAFIMPVLIITVCY 254
Cdd:cd15170  161 T------PEQLKILlpvrleLFLVLFCIPFLITCFCY 191
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
74-340 6.26e-14

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 71.77  E-value: 6.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIvrYTKMKTATNIYIF--NLALADALATStlpFQSVNYLMGTWPF----GTILCKIVIS 147
Cdd:cd15387    4 VTVLALILFLALTGNICVLLAI--HTTRHKHSRMYFFmkHLSIADLVVAV---FQVLPQLIWDITFrfygPDFLCRLVKY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIInvcNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHP 226
Cdd:cd15387   79 LQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLF---SWLLSLVFSIPqVHIFSLREVGNGVYDCWADFIQP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 -------TWywenllkicVFIFAFIMPVLIITVCYGL-----------------------------MILRLKSVRMLSGS 270
Cdd:cd15387  156 wgpkayiTW---------ITLSVYIIPVLILSVCYGLisfkiwqnvklktrretktplssaasggaALARVSSVKLISKA 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 271 KekdrnlRRITRMVLVVVAVFIVCWTPihIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 340
Cdd:cd15387  227 K------IRTVKMTFVIVLAYIVCWTP--FFFVQMWSVWDPNAPKEASPFIIAMLLASLNSCCNPWIYMF 288
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
71-349 1.00e-13

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 70.98  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15296    1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGfCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRT----PRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI---DCTLT 222
Cdd:cd15296   81 YLLCTASVFNIVLISYDRFLSV---TRAVSYRAqkgmTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSIIpegECYAE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 223 FSHpTWYWenllKICVFIFAFIMPVLIITVcYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYV 302
Cdd:cd15296  158 FFY-NWYF----LMTASTLEFFTPFISVTY-FNLSIYLNIQKRRFRLSRDK-----KVAKSLAIIVCVFGLCWAPYTLLM 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 550822324 303 IIKALV---TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15296  227 IIRAAChghCVPDYWYETSFW-----LLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
72-349 1.52e-13

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 70.73  E-value: 1.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTIL---CKIVIS 147
Cdd:cd15069    2 TYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADvAVGLFAIPFAITISLGFCTDFHSCLflaCFVLVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDyynmfTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLpVMFMATTKYRQGSIDCTLTFSHPT 227
Cdd:cd15069   82 TQ-----SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGL-TPFLGWNKAMSATNNSTNPADHGT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WY--------WENLLKICVFIF-----AFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRNLRRITRMVLVVVAV 290
Cdd:cd15069  156 NHscclisclFENVVPMSYMVYfnffgCVLPPLLIMLVIYIKIFLvacrQLQRTELMDHSRTTLQREIHAAKSLAIIVGI 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550822324 291 FIVCWTPIHIYVIIKALVtiPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15069  236 FALCWLPVHILNCITLFQ--PEFSKSKPKWamNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
75-348 2.52e-13

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 69.85  E-value: 2.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQS-VNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15076    5 AFMGFVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVfVASAQGYFFFGRTVCALEAFVGSLAG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTpRNAKIINVCNWILSSAIGLPVmFMATTKYRQGSIDCTLTfshPTWYW--- 230
Cdd:cd15076   85 LVTGWSLAFLAFERYIVICKPFGNFRFGS-KHALGAVVATWIIGIGVSLPP-FFGWSRYIPEGLQCSCG---PDWYTvgt 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 ---ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSV---RMLSGSKEKDRnlRRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15076  160 kyrSEYYTWFLFIFCFIVPLSIIIFSYSQLLGALRAVaaqQQESASTQKAE--REVSRMVVVMVGSFCLCYVPYAALAMY 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 305 KA----------LVTIPettfqtvswhfciALGYTNSCL-NPVLYAFLDENFKRC 348
Cdd:cd15076  238 MVnnrdhgldlrLVTIP-------------AFFSKSSCVyNPIIYCFMNKQFRAC 279
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
73-349 3.44e-13

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 69.24  E-value: 3.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYL-------MGTWPFgtILCKIV 145
Cdd:cd14972    1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLlvsltpsPATWLL--RKGSLV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 146 ISidyynMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMFMATTKYRQGSidCTLTFS 224
Cdd:cd14972   79 LS-----LLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAlLPVLGWNCVLCDQES--CSPLGP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HptwYWENLLkICVFIFaFIMPVLIITVCYGLMILRLKS--VRMLSGSKEKDRNLRRITRMVLVVVAVFI----VCWTPI 298
Cdd:cd14972  152 G---LPKSYL-VLILVF-FFIALVIIVFLYVRIFWCLWRhaNAIAARQEAAVPAQPSTSRKLAKTVVIVLgvflVCWLPL 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 299 HIYVIIkaLVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14972  227 LILLVL--DVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
73-346 6.31e-13

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 68.64  E-value: 6.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15398    3 LIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVvLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKalDFRTPRNAKIINVCNWILSSAIGLPV-MFMATTKYRQGSIDCTLTF------S 224
Cdd:cd15398   83 SVMVSTLMLMSIAIVRYHMIKHPLS--NHLTANHGYFLLGTVWTLGFTICSPLpVFHKIVDLSETFNLESLKNkylcieS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRmlsgskekdRNLRRITRMVLVVVAVfivcWTPIHIYVII 304
Cdd:cd15398  161 WPSDSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSVKRSR---------SVFYRLTIVILAFAVS----WMPLHLFHLV 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 305 KALVT--IPETTFQTVsWHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15398  228 TDFNAnlISNRHFKLV-YCICHLLGMLSCCLNPILYGFLNNGIK 270
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
79-347 1.02e-12

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 68.00  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL--------ATSTLPFQSV-NYLMGTWpFGTILCKIVISID 149
Cdd:cd15137    9 VVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLmgvylliiASVDLYYRGVyIKHDEEW-RSSWLCTFAGFLA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFrTPRNAKIINVCNWILSSAI-GLPVMFMATTKYRQG-SIDC-TLTFSHP 226
Cdd:cd15137   88 TLSSEVSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLaVLPLLPWDYFGNFYGrSGVClPLHITDE 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 T---WYWENLLKICVFIFAFimpvLIITVCYGLMILRLKSVRmLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIhiyVI 303
Cdd:cd15137  167 RpagWEYSVFVFLGLNFLAF----VFILLSYIAMFISIRRTR-KAAASRKSKRDMAVAKRFFLIVLTDFLCWIPI---IV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 550822324 304 IKAL----VTIPETTFqtvSWHFCIALGyTNSCLNPVLYAFLDENFKR 347
Cdd:cd15137  239 IGILalsgVPIPGEVY---AWVAVFVLP-INSALNPILYTLSTPKFRK 282
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
73-349 1.22e-12

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 67.84  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATN-IYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd14983    3 SLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSsaiGLPVMFMATTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd14983   83 TLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALV---IFHVTLVFILETSGGTLDINTPVGNSSTCYE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NL------------LKICVFIfaFIMPVLIITVCYglmilrLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIH 299
Cdd:cd14983  160 NFtpeqlallapvrLELSLVL--FFLPLAITAFCY------VRCIRILVRSRLHERRKRRAVRVAVSTLLTFVVCFGPYN 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550822324 300 IYVIIKALVTipettfQTVSWHfCIAL--GYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd14983  232 ISHVVGFVRH------ESVWWR-KLALltSTCNAFLDPLIFYFLSSSMERGF 276
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
74-346 1.70e-12

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 67.00  E-value: 1.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCV---VGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd15072    1 FAVGSILLVealVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPvkalDFRTPRNAKIINVCNWILSSA-IGLPVMFMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15072   81 FTALASICSSAAIAWDRYHHYCTR----SKLQWSTAISLVLFVWLFSAFwAAMPLLGWGEYDYEPLGTCCTLDYSKGDRN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLkICVFIFAFIMPVLIITVCYGLMILRLKsvrmlsgsKEKdrnlrRITRMVLVVVAVFIVCWTPihiYVIIKALVT 309
Cdd:cd15072  157 YVSYL-FTMAFFNFILPLFILLTSYSSIEQKLK--------KEG-----HLRFNTGLPLLTLLICWGP---YAILALYAA 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 IPETTFqtVS---WHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15072  220 ITDVTS--ISpklRMVPALLAKTSPTINAILYALGNENYR 257
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
79-347 1.72e-12

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 67.24  E-value: 1.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVI-VRYTKMkTATNIYIFNLALAD--------ALATSTLPFQSVNYLMGT-WPFGTiLCKIVISI 148
Cdd:cd15136    9 FVFLLALVGNIIVLLVLlTSRTKL-TVPRFLMCNLAFADfcmgiylgLLAIVDAKTLGEYYNYAIdWQTGA-GCKTAGFL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKaLDFR-TPRNAKIINVCNWILSSAIG-LPVMFMATtkYRQGSIdCtLTFSHP 226
Cdd:cd15136   87 AVFSSELSVFTLTVITLERWYAITHAMH-LNKRlSLRQAAIIMLGGWIFALIMAlLPLVGVSS--YSKTSI-C-LPFETE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TwyweNLLKICV-FIFAF-IMPVLIITVCYGLMILRLKSVRMLSGSKEkdrnlRRITRMVLVVVAVFIVCWTPIHIYVII 304
Cdd:cd15136  162 T----PVSKAYViFLLLFnGLAFLIICGCYIKIYLSVRGSGRAANSND-----TRIAKRMALLVFTDFLCWAPIAFFGLT 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 305 KA----LVTIPETTFQTVswhFCIALgytNSCLNPVLYAFLDENFKR 347
Cdd:cd15136  233 AAfglpLISVSNAKILLV---FFYPL---NSCANPFLYAIFTKQFRR 273
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
74-349 4.86e-12

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 66.11  E-value: 4.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQ---SVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15068    4 ITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADiAVGVLAIPFAitiSTGFCAACHGCLFIACFVLVLTQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 yynmfTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAK-IINVCnWILSSAIGLPVMF------------MATTKYRQGS 216
Cdd:cd15068   84 -----SSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKgIIAIC-WVLSFAIGLTPMLgwnncgqpkegkNHSQGCGEGQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 217 IDCTLTFSHPTWYwenlLKICVFIFAFIMPVLIITVCYGLMIL----RLKSVRMLSGSKEKDRN-LRR---ITRMVLVVV 288
Cdd:cd15068  158 VACLFEDVVPMNY----MVYFNFFACVLVPLLLMLGVYLRIFLaarrQLKQMESQPLPGERARStLQKevhAAKSLAIIV 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550822324 289 AVFIVCWTPIHiyvIIKALVTIPETTFQTVSW--HFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15068  234 GLFALCWLPLH---IINCFTFFCPDCSHAPLWlmYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
71-349 6.97e-12

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 65.36  E-value: 6.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGT-WPFGTILCKIVISI 148
Cdd:cd15328    1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLvAALVMPLSLVHELSGRrWQLGRSLCQVWISF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGL-PVMFMATTKYRQGSIDCTLTfSHPT 227
Cdd:cd15328   81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLaPLLFGWGETYSEDSEECQVS-QEPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 228 WywenllKICVFIFAFIMPVLIITVCYGLMilrlksvrMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKAL 307
Cdd:cd15328  160 Y------TVFSTFGAFYLPLCVVLFVYWKI--------YKAAQKEK-----RAALMVGILIGVFVLCWIPFFLTELISPL 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 550822324 308 VT--IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15328  221 CScdIPPIWKSIFLW-----LGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
76-347 7.54e-12

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 65.57  E-value: 7.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATnIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15151    6 LYTVLFLVGLILNSVAAWIFFHIPSTSTFI-VYLKNTLVADLIMTLMLPFKILsDSGLGPWQLRAFVCRFSAVVFYITMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI-DCTLTFSHPTWYW-EN 232
Cdd:cd15151   85 ISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPISVkKCASLKSPLGLKWhEV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 LLKICVFIFAFIMPVLIitVCYglMILRLKSVRMLSGSKEKDRNLRRITRMVL-VVVAVFIVCWTPIHiyviikaLVTIP 311
Cdd:cd15151  165 VNYICQFIFWGVFALMV--LFY--TIISKKVYESYKKSRSKDNKASKKTKAKVfIIVAVFFVCFAPFH-------FVRVP 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 312 ETTFQTVSWHFCIA-------------LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15151  234 YTLSQTGKITDCQLqnllyiakeitlwLAATNVCLDPLIYIFLCKSFRQ 282
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
71-349 2.06e-11

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 64.43  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFL---VMYVIVRYTKMKTATNIYIFNLALADALATST-LP--FQSVNYLMGTWPFGTILCKI 144
Cdd:cd15135    1 ITLTLLYSLILVAGILGNSAtikVTQVLQKKGYLQKSVTDHMVSLACSDLLVLLLgMPveLYSAIWDPFATPSGNIACKI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 145 visidYYNMF-----TSIFTLCTMSVDRYIAVCHPVKALDFRtPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDC 219
Cdd:cd15135   81 -----YNFLFeacsyATILNVATLSFERYIAICHPFKYKALS-GSRVRLLICFVWLTSALVALPLLFAMGTEDPLEAFPS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 220 TLTFSHPTWYWENLLKIC--------VF---IFAFIMPVLIITVCYGLMILRLKSVRMLSG------------------- 269
Cdd:cd15135  155 YRGTRHHCQDQKSNLTICtslsskwtVFqasIFSAFVLYLLVLASVAFMCRRMMRALMGSKkgavavkgpggsvqllrkh 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 270 -SKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETT---------FQTVSWHFCialgYTNSCLNPVLYA 339
Cdd:cd15135  235 eSAEGKTARKQTILFLGLIVGTLAVCWMPNQIRRIMAAAKPKDDWTrsyfrayiiLLPIADTFF----YLSSVLNPLLYN 310
                        330
                 ....*....|
gi 550822324 340 FLDENFKRCF 349
Cdd:cd15135  311 LSSQQFRSVF 320
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
71-349 2.22e-11

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 63.91  E-value: 2.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15331    1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMvAVLVMPLSAVYEVSQHWFLGPEVCDMWISMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHpVKALDFRTPRNAKIINVCNWILSSAIGLPVMFmattkyrqgsidctlTFSHPT-W 228
Cdd:cd15331   81 VLCCTASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLF---------------GWKDEDdL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVF-------IF----AFIMPVLIITVCYglmilrlksVRMLSGSKEKdrnlRRITRMVLVVVAVFIVCWTP 297
Cdd:cd15331  145 DRVLKTGVCLIsqdygytIFstvgAFYVPLLLMIIIY---------WKIYQAAKRE----RKAARTLAIITGAFVVCWLP 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 298 IHIYVIIKALV---TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15331  212 FFLVALVMPFCgawQISRFLESFFLW-----LGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
80-348 5.13e-11

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 62.92  E-value: 5.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  80 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCkiVISIDYYNMF--TS 156
Cdd:cd15078   10 IGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLgVTFTFMSCVRGRWVFDVAGC--VWDGFSNSLFgiVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHpVKALDFRTPRNAkIINVcnWILSSA-IGLPVMFMATTKYRQGSIDCTLTFShPTWYWENLLK 235
Cdd:cd15078   88 IMTLTVLAYERYIRVVH-AKVVNFSWSWRA-ITYI--WLYSLAwTGAPLLGWNRYTLEVHGLGCSFDWK-SKDPNDTSFV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFAFIMPVLIITVCYGLM---ILRLKSVRMLSGSKEKD--RNLRRITRMVLVVVAVFIVCWTPihiYVIIKALVTI 310
Cdd:cd15078  163 LLFFLGCLVVPLGIMAYCYGHIlyeIRMLRSVEDLQTFQVIKilKYEKKVAKMCLLMISTFLICWMP---YAVVSLLVTS 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 311 PETTFQTVSWHFCIAL-GYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15078  240 GYSKLVTPTIAIIPSLfAKSSTAYNPVIYIFMIRKFRQC 278
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
79-347 7.41e-11

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 62.09  E-value: 7.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKT-ATNIYIFNLALADALAT-STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTS 156
Cdd:cd15219    8 VVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTvLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 157 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPtwywENLLKI 236
Cdd:cd15219   88 MLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGYSSLYASCTLHLPRE----EERRRF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 237 CVF-----IFAFIMPVLIITVCYgLMILRLksvrmlsgskekdRNLRRITRMVLVVVAVFIVCWTPihiYVIIKALVTIP 311
Cdd:cd15219  164 AVFtaffhAFTFLLSLLVLCVTY-LKVLKV-------------RRRQRATKKISIFIGTFVLCFAP---YVITRLVELLP 226
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 550822324 312 ettFQTVSWHFCI---ALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15219  227 ---FVTINRYWGIvskCLTYSKAASDPFVYSLLRQQYRK 262
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
71-349 7.65e-11

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 62.13  E-value: 7.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15054    1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMvGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWY 229
Cdd:cd15054   81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTVEGQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFA----FIMPVLIITVCYGLMILRLKsvRMLSGSkekdRNLRRITRMVLVVvavfivcWTPIHIYVIIK 305
Cdd:cd15054  161 CRLLVSLPYALVAscltFFLPSGAICFTYCRILLAAR--KALKAS----LTLGILLGMFFVT-------WLPFFVANVVQ 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 306 ALV-TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15054  228 AVCdCVSPGLFDVLTW-----LGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
71-203 1.19e-10

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 62.17  E-value: 1.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15403    1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDiMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLY 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIINVCNWILSSAIGLP 203
Cdd:cd15403   81 WFFVLEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFP 131
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
70-344 1.31e-10

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 61.71  E-value: 1.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  70 AITIMALYSIVCVVGLfGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMG-TWPFGTILCKIVIS 147
Cdd:cd15212    1 AAQALVLLAIFLLSSL-GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPFAFLTLFSRpGWLFGDRLCLANGF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRtPRNAKIINVCnWILSSAIGLPVMFMAT---TKYRQGSIDCTLTFS 224
Cdd:cd15212   80 FNACFGIVSTLTMTLISFDRYYAIVRQPQGKIGR-RRALQLLAAA-WLTALGFSLPWYLLASapeYYEKLGFYHCLYVLH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 HPTWYWENLLKICVFIFAFIMPVLIITVC-YGL-MILRLKSVRMLSGSKEKdRNLR-----RITRMVLVVVAVFIVCWTP 297
Cdd:cd15212  158 SGPSRLGAAYSSVLIVLCYLLPFALMCFChYNIcKTVRLSESRVRPVTTYA-HLLRfysemRTATTVLIMIVFIICCWGP 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 298 IHIYVIIKAL--VTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDEN 344
Cdd:cd15212  237 YCLLGLVAAAggYQFPPLMDTVAIW-----MAWANGAINPLIYAIRNPN 280
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
70-206 9.03e-10

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 59.78  E-value: 9.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  70 AITIMALYSIVCVvGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPF--QSVNYLMGtWPFGTILCKIVI 146
Cdd:cd15005    1 ALKLTTLGLILCV-SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLrSLACFPFvmASVRHGSG-WIYGALSCKVIA 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550822324 147 SIDYYNMFTSIFTLCTMSVDRYIAVCHP-VKALDFRTPRNAKIINVCnWILSSAIGLPVMF 206
Cdd:cd15005   79 FLAVLFCFHSAFTLFCIAVTRYMAIAHHrFYAKRMTFWTCLAVICMA-WTLSVAMAFPPVF 138
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
71-346 1.03e-09

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 58.70  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADA-LATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15404    1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMmLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIINVCNWILSSAIGLPVMF-MATTKYRQGSIDCTLTFSHPTW 228
Cdd:cd15404   81 WLFVMEGVAILLIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVgSPDLQIPSRAPQCVFGYTTNPG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YweNLLKICVFIFAFIMPVLIITvcYGLMILrLKSVRMLsgskeKDRNLRRITRMVLVvvavFIVCWTPIHIYVIIKALV 308
Cdd:cd15404  158 Y--QAYVILIMLIFFFIPFMVML--YSFMGI-LNTVRSF-----KTRAFTTILILFIV----FTVCWAPFTTYSLVATFN 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 309 T---IPETTFQTVSWhfCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15404  224 ShfyHKHNFFEISTW--LLWLCYLKSALNPLIYYWRIKKFR 262
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
79-348 1.89e-09

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 58.38  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD---ALATSTLPFqsVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd15081   21 FVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADlgeTVIASTISV--VNQIFGYFILGHPMCVLEGFTVSVCGIT 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIInVCNWILSSAIGLPVMFMATTKYRQG-SIDCTL-TFSHPTWYWENL 233
Cdd:cd15081   99 GLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGI-IFSWVWSAVWCAPPIFGWSRYWPHGlKTSCGPdVFSGSSDPGVQS 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFIFAFIMPVLIITVCYGLMILRLKSV-RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAlvTIPE 312
Cdd:cd15081  178 YMIVLMITCCIIPLAIIILCYLQVWLAIRAVaQQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPYTFFACFAA--ANPG 255
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 550822324 313 TTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRC 348
Cdd:cd15081  256 YAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNC 291
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
74-349 4.35e-09

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 57.16  E-value: 4.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTilCKIVISIDYYN 152
Cdd:cd15071    4 IGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLIL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYR-QGSIDCTLTFSHP--TWY 229
Cdd:cd15071   82 TQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAvERAWAANSSMGELviKCQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFI----FAFIMPVLIITVCYGLMILRL--KSVRMLSGSKEKDRNLR-----RITRMVLVVVAVFIVCWTPI 298
Cdd:cd15071  162 FETVISMEYMVyfnfFVWVLPPLLLMLLIYLEVFYLirKQLNKKVSSSSSDPQKYygkelKIAKSLALILFLFALSWLPL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 299 HIYVIIKALVtiPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15071  242 HILNCITLFC--PSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
74-304 6.19e-09

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 56.87  E-value: 6.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIF--NLALADALAT-STLPFQSVNYLMG-TWPFGTILCKivisid 149
Cdd:cd14981    4 PAPPALMFVFGVLGNLLALIVLARSSKSHKWSVFYRLvaGLAITDLLGIlLTSPVVLAVYASNfEWDGGQPLCD------ 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 yYNMFTSIFT-------LCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVM-FMATTKYRQGSIdCT 220
Cdd:cd14981   78 -YFGFMMSFFglsslliVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAsLPLLgLGSYVLQYPGTW-CF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 221 LTFSHPTWywenLLKICVFIFAFIMPVLI-------ITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMV---LVVVAV 290
Cdd:cd14981  156 LDFYSKNT----GDAAYAYLYSILGLLILlvtllcnLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVvllLAITVV 231
                        250
                 ....*....|....
gi 550822324 291 FIVCWTPIHIYVII 304
Cdd:cd14981  232 FSVCWLPLMIRVLI 245
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
78-346 8.81e-09

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 56.32  E-value: 8.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  78 SIVCVVGL---FGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTIL---CKIVisidy 150
Cdd:cd15070    5 SIEILIGLcavVGNVLVIWVVKLNPSLRTTTFYFIVSLALADiAVGVLVIPLAIVVSLGVTIHFYSCLfmsCLLV----- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 ynMFT--SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF---MATTKYRQGS--IDCTLT- 222
Cdd:cd15070   80 --VFThaSIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFgwnRKPSLESVNTtpLQCQFTs 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 223 ---------FSHPTWywenllkicVFIFAFIMPVLIITVCYglmILRLKSVRMLSGSKEKDRNLRR---ITRMVLVVVAV 290
Cdd:cd15070  158 vmrmdymvyFSFFTW---------ILIPLVIMCALYVDIFY---IIRNKLSQNATGFRETGAFYGRefkTAKSLALVLFL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 550822324 291 FIVCWTPIHIY-VIIKALVTIPETTFqtvswHFCIALGYTNSCLNPVLYAFLDENFK 346
Cdd:cd15070  226 FAVCWLPLSIInCVVYFNPKVPKIAL-----YLGILLSHANSMMNPIVYACKIKKFK 277
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
79-283 2.48e-08

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 54.53  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324   79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-----LPFQSVNYLMGTWPFGTILCKIVISIDYYNm 153
Cdd:pfam10328   2 LISLIGLVANLLVFIAFLKLPSLKNSFGILCLSQAIGNAIICLIflfyvVPMTLFQNSFLPEWLNSHIIGLIAMGLYEI- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  154 ftSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFmattkyrqgSIDCTLTFSHPTWYWENL 233
Cdd:pfam10328  81 --SPLSHLLIALNRFCAVFFPLKYEKIFSIKNTKIIIIFIWIVSIIFCTVFYE---------PEGCHFYYNPETLTWSFE 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 550822324  234 L-KICVFI-----FAFIMPVLIITVCYGLMI---LRLKSVRMLSGSKEKDRNLRRITRM 283
Cdd:pfam10328 150 DtPCCDFItwyldFYKNLSLVIITLFLNLLTaikLRVSKKKSNTSSSESKRRRKREINF 208
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
82-342 4.71e-08

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 53.99  E-value: 4.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTAtnIYIFNLALADALATSTL-PFQ--SVNYLMGTWPFGTILCKIVISIDYYNMFTSIF 158
Cdd:cd15220   11 LTALVGNTAVMVVIAKTPHLRKF--AFVCHLCVVDLLAALLLmPLGilSSSPFFLGVVFGEAECRVYIFLSVCLVSASIL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 159 TLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSI---DCTLTFSHptwywENLLK 235
Cdd:cd15220   89 TISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIaarHCSLHWSH-----SGHRG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 236 ICVFIFA---FIMPVLIITVCYGLMIlrlksvRMLSGSKEkdrnlrriTRMVLVVVAVFIVCWTPIHIYVIIKALVTIPE 312
Cdd:cd15220  164 VFVVLFAlvcFLLPLLLILVVYCGVF------KVFGGGKA--------ALTLAAIVGQFLCCWLPYFAFHLYSALAASPV 229
                        250       260       270
                 ....*....|....*....|....*....|...
gi 550822324 313 TTFQ---TVSWhfciaLGYTNSCLNPVLYAFLD 342
Cdd:cd15220  230 SGGEaeeVVTW-----LAYSCFAVNPFFYGLLN 257
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
74-349 9.60e-08

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 53.41  E-value: 9.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGT-WPFGTILCKIVISIDYY 151
Cdd:cd15217    4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVcFPFVLVSIRNGSaWTYSVLSCKIVAFMAVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHP---VKALDFRTPrnakIINVCN-WILSSAIGLPVMF-MATTKYRQGSIDCtlTFSHP 226
Cdd:cd15217   84 FCFHAAFMLFCISVTRYMAIAHHrfySKRMTFWTC----IAVICMvWTLSVAMAFPPVFdVGTYKFIREEDQC--IFEHR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 TWYWENLLKicvfiFAFIMPVLIIT--VCYGLMIL------RLKSVRMLSGSKE-------------------------- 272
Cdd:cd15217  158 YFKANDTLG-----FMLMLAVLIVAthIVYGKLLLfeyrhrKMKPVQMVPAISQnwtfhgpgatgqaaanwiagfgrgpm 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 273 -------------KDRNL---------RRITRMVLVVVAVFIVCWTPIHI----YVIIKAlVTIPETTFQTVSWhfciaL 326
Cdd:cd15217  233 pptllgirqnahtANRRLlgmeefkaeKRLGRMFYVITLSFLVLWSPYIVacywRVFVKA-CSIPHRYLSTAVW-----M 306
                        330       340
                 ....*....|....*....|...
gi 550822324 327 GYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15217  307 SFAQAGVNPIVCFLLNKDLKKCL 329
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
70-257 3.04e-07

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 51.48  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  70 AITIMALYSIVCVvglfGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:cd15214    3 SIAIIIIAILICL----GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNlLLSVLVLPFVVTSSIRREWIFGVVWCNFSALL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF-MATTKYRQGSIDCTLTFSHP- 226
Cdd:cd15214   79 YLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFgWSSLEFDRFKWMCVAAWHKEa 158
                        170       180       190
                 ....*....|....*....|....*....|...
gi 550822324 227 --TWYWEnllkicvfIFAFIMPVLIITVCYGLM 257
Cdd:cd15214  159 gyTAFWQ--------VWCALLPFVVMLVCYGFI 183
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
72-174 3.26e-07

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 51.73  E-value: 3.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIY--IFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:cd15142    2 TPPTIPAVMFIFGVVGNLIAIVVLCKSRKEQKETTFYtlVCGLAVTDLLGTClASPVTIATYLKGRWPGGQPLCEYFSFI 81
                         90       100
                 ....*....|....*....|....*.
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHP 174
Cdd:cd15142   82 LLFFSLSGLSIICAMSIERYLAINHA 107
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
70-349 1.16e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 49.68  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  70 AITIMALYSIVCVVGlfgNFLVMYVIVRYTKMK-TATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGTILCKIVIS 147
Cdd:cd15104    2 AGVILAVLSPLIITG---NLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSdGENTQKVLCLLRMC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMFMATTKYRQGSIDCTLTFSHP 226
Cdd:cd15104   79 FVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGfLPLISPQFQQTSYKGKCSFFAAFHP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 twywENLLKICVFIFAFIMPVLIITVCYGLMILRLKS--VRMLSGSKEKDRNLRRIT------RMVLVVVAVFIVCWTPI 298
Cdd:cd15104  159 ----RVLLVLSCMVFFPALLLFVFCYCDILKIARVHSraIYKVEHALARQIHPRRTLsdfkaaRTVAVLIGCFLLSWLPF 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 299 HIYVIIKALVTIPETTFQTVSWHFciALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15104  235 QITGLVQALCDECKLYDVLEDYLW--LLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
73-170 1.53e-06

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 49.47  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15127    3 VMCLSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFfCLPLVIFHELTKKWLLGDFSCKIVPYIEVA 82
                         90
                 ....*....|....*....
gi 550822324 152 NMFTSIFTLCTMSVDRYIA 170
Cdd:cd15127   83 SLGVTTFTLCALCIDRFRA 101
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
59-352 1.63e-06

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 49.81  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  59 CPPTGSPSMITaITIMALYSIVCVVGLFGNFLVMYVIV---RYTKMKTATnIYIFNLALADALATSTLPF--QSVNYLMG 133
Cdd:PHA03235  22 CVPTEGLSAAR-TTETFINLLIISVGGPLNLIVLVTQLlanRVHGFSTPT-LYMTNLYLANLLTVFVLPFimLSNQGLLS 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 134 TWPFGtilCKIViSIDYYNMFTSIF-TLCTMSVDRYiAVCHPVKALDFRTPRNAKIINVCNW----ILSSAIGLPVMFMA 208
Cdd:PHA03235 100 GSVAG---CKFA-SLLYYASCTVGFaTVALIAADRY-RVIHQRTRARSSAYRSTYKILGLTWfaslICSGPAPVYTTVVA 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 209 TTKYRQGSID---CTLTFSHPTWYweNLL---KICVFIFAFIMPVLIITVCYGLMILRLKsvrmLSGSKEKDRNLRRITR 282
Cdd:PHA03235 175 HDDVDPEAPGyetCVIYFRADQVK--TVLstfKVLLTLVWGIAPVVMMTWFYTFFYRTLK----RASYKKRSRTLTFVCI 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 283 MVLVVVAVFivcwTPihiYVIIKALvtipeTTFQTVSWHF-CIALGYTNS------------CL-NPVLYAFLDENFKRC 348
Cdd:PHA03235 249 LLLSFLCLQ----TP---FVAIMIF-----DSYATLIWPSdCEHINLRDAvstlsrlvpnlhCLlNPILYAFLGNDFLKR 316

                 ....
gi 550822324 349 FREF 352
Cdd:PHA03235 317 FRQC 320
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
75-196 1.78e-06

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 49.24  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMK-TATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGTILCKIVISIDYYN 152
Cdd:cd15169    5 GLYVAAFALGFPLNVLAIRGATAHARLRlTPSLVYALNLGCSDLLLTVSLPLKAVEALAsGAWPLPASLCPVFAVAHFAP 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWIL 196
Cdd:cd15169   85 LYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWAL 128
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
76-270 2.41e-06

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 48.64  E-value: 2.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFT 155
Cdd:cd14994    7 LYSVVLIGGVIGVILMSFLLVKMNT-RSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMHL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFsHPTWYWENLLK 235
Cdd:cd14994   86 TFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFVKEYGSSSSYNSDQCFKF-HKELEVHYVKV 164
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 550822324 236 ICVFIFAFIMPVLIITVCYGLMILrLKSVRMLSGS 270
Cdd:cd14994  165 LNYIIICIVLIVTLALLGFQVFIL-GHVYRKLRAS 198
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
71-347 5.63e-06

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 47.88  E-value: 5.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVcVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMG-TWPFGTILCKIVISI 148
Cdd:cd15198    2 TRLIFLGVIL-VAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGgTALSQIIWELLGdRWMAGDVACRLLKLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPvkaldFRTPRNAKIINVCNWILSSAIGLPVMFM-------ATTKYRQGSIDCTL 221
Cdd:cd15198   81 QASARGASANLVVLLALDRHQAIRAP-----LGQPLRAWKLAALGWLLALLLALPQAYVfrvdfpdDPASAWPGHTLCRG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 222 TFS-HPTWYWENLLkICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRIT------------------R 282
Cdd:cd15198  156 IFApLPRWHLQVYA-TYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKShlratapsalprakvktlK 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550822324 283 MVLVVVAVFIVCWTPIHIYVIIKALVT---IPETTFQTVSwhfciALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15198  235 MTLVIALLFVGCSLPYFIAELAAAFGSgdwEPEKVAAALG-----VMAVANSATNPFVFLFFNAGDCR 297
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
77-195 6.00e-06

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 47.58  E-value: 6.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRYT--KMKTATNiYIFNLALADALATSTLPFqsVNYLMGTW----PFGTILCKIVISIDY 150
Cdd:cd15919    7 YSLLLCLGLPANILTVIILSQLVarRQKSSYN-YLLALAAADILVLFFIVF--VDFLLEDFilnkQMPQVLDKIIEVLEF 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWI 195
Cdd:cd15919   84 SSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYI 128
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
71-174 1.44e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 46.45  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGtwpFGTI---LCKIVI 146
Cdd:cd15431    1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDiCYTTSSVPQMLVNCLSD---RPTIsysRCLAQM 77
                         90       100
                 ....*....|....*....|....*...
gi 550822324 147 SIDYYNMFTSIFTLCTMSVDRYIAVCHP 174
Cdd:cd15431   78 YISLFLGITECLLLAVMAYDRFVAICNP 105
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
76-349 2.00e-05

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 46.00  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCkIVISIDYYNMF 154
Cdd:cd15211    5 VYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFwMPQEAVLGSTGTLLVLGYRL-FREGLLFLGLT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCH-PVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATtkYRQGSIDCTLTFSHPTWYWENL 233
Cdd:cd15211   84 VSLLSHSLIALNRYVLITKlPAVYQALYQKRNTEWMIALSWALALGLLLPWLTSFR--YPTKSCHDSADGSFAVVSVLSS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 234 LKICVFI-FAFIMPVLIITVCYgLMILR-----LKSVRMLSGSKEKD-----RNLRRITRMVLVVVAVFIVCWTPIHIYV 302
Cdd:cd15211  162 RYPALLLaFTVLGQTALVLHCY-FGIFRrvqisVKRVSVLNFQIVNNlpysrPRKDKRLGLYVLLVCCVFLLTTEPLVWV 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 303 IIKALVTIPETTFQTVSWHFCIALgytnSCLNPVLYAFLDENFKRCF 349
Cdd:cd15211  241 SLAGLFVPVPVALQTASWLLFCTL----FVLNPFLYTWKNEEFRRSF 283
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
71-341 2.27e-05

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 45.71  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKmKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY 150
Cdd:cd14973    1 LVIFSLTVLLSLCGLVGNGLVLWLLGFRIK-RNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPvmfmattkyrqGSIDCTLTFSHPTWYW 230
Cdd:cd14973   80 FSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVL-----------ESYFCGFLFWKFNESA 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 231 -ENLLKICVFIFAFIMPVLIITvcyGLMILrlksVRMLSGSKEkdRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALvt 309
Cdd:cd14973  149 cRTFNFLSALLFLLLFLVMCVS---SLTLL----IRVQCSSQR--RPPTRLYVVILLTVLVFLLCGLPLGIYWFLLLW-- 217
                        250       260       270
                 ....*....|....*....|....*....|....
gi 550822324 310 IPETTFQTVSW--HFCIALgytNSCLNPVLYAFL 341
Cdd:cd14973  218 FSNYLFHTFHPisDLLSCV---NSSANPIIYFFV 248
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
83-221 3.54e-05

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 45.41  E-value: 3.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  83 VGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMG-TWPFGTILCKIVISIDYYNMFTSIFTL 160
Cdd:cd15218   13 VSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAIcFPFVFTSVKNGsTWTYGTLTCKVIAFLGVLSCFHTAFML 92
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 161 CTMSVDRYIAVCHP---VKALDFRTPrnakIINVCN-WILSSAIGL-PVMFMATTKYRQGSIDCTL 221
Cdd:cd15218   93 FCISVTRYLAIAHHrfyTKRLTFWTC----LAVICMvWTLSVAMAFpPVLDVGTYSFIREEDQCTF 154
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
76-206 3.90e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 45.16  E-value: 3.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-------LPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:cd15350    6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYktlenilIILADMGYLNRRGPFETKLDDIMDSL 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMF 206
Cdd:cd15350   86 FCLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGiLMILF 144
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
76-349 4.21e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 44.90  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSV------NYLMGTWPFGTILCKIVISID 149
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVvitllnGNDTDAQSFTVNIDNVIDSVI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGlpVMFMattkyrqgsidctltfshpTWY 229
Cdd:cd15353   86 CSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSG--VLFI-------------------IYS 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMPVLIITV---CYGLMILRLKSVRMLSGSKekdrNLRRITRMVLVVVAVF-----IVCWTPIHIY 301
Cdd:cd15353  145 DSSVVIICLISMFFTMLALMASLyvhMFLLARLHIKRIAVLPGTG----PIRQGANMKGAITLTIllgvfVVCWAPFFLH 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 302 VIIkaLVTIPETTFQTV---SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15353  221 LIF--YISCPRNPYCVCfmsHFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
75-176 4.32e-05

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 45.08  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMG--TWPFGTILCKIVISIDYY 151
Cdd:cd15429    5 VLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDiCYTTSVVPQMLAHFLAEhkTISFASCVAQLFISLALG 84
                         90       100
                 ....*....|....*....|....*
gi 550822324 152 NmfTSIFTLCTMSVDRYIAVCHPVK 176
Cdd:cd15429   85 G--TEFILLAVMAYDRYVAVCHPLR 107
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
82-349 5.38e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 44.40  E-value: 5.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-------ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15103   12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADmlvsvsnALETIVIILLNNGYLVPRDSFEQHIDNVIDSMICSSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGlpVMFMAttkyrqgsidctltFSHPTwywenLL 234
Cdd:cd15103   92 ASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCG--ILFII--------------YSDSV-----PV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVLIITVcYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVF-----IVCWTPIHIYVIIkaLVT 309
Cdd:cd15103  151 IICLISMFFAMLVLMASL-YVHMFLLARSHVKKIAALPGQRSTRQRANMKGAVTLTIllgvfIFCWAPFFLHLTL--MIS 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 310 IPETTF---QTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15103  228 CPSNPYcacYMSHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
76-347 7.51e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 44.01  E-value: 7.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-------TSTLPFQSVNYLMGTWPFGTILCKIVISI 148
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVsvsnlieTLFMLLLEHGVLVCRAPMLQHMDNVIDTM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAiglpvmfmattkyrqgsidCTLTFShpTW 228
Cdd:cd15351   86 ICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTV-------------------SSTLFI--VY 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVF-----IVCWTPIHIYVI 303
Cdd:cd15351  145 YNSNAVILCLIVFFLFMLVLMLVLYIHMFILACRHSQSISSQQRRQCPHQQTASLKGAITLTIllgifFLCWGPFFLHLT 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 304 IkaLVTIPETTFQTVSW-HFCI--ALGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15351  225 L--IVTCPTHPFCLCYFkYFNLflILIICNSIIDPLIYAFRSQELRK 269
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
82-202 8.08e-05

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 44.14  E-value: 8.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMG--TWPFGTILCKIVISIDYYNMftSIF 158
Cdd:cd15918   12 LVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTStTVPKMLVNIQTQskSISYAGCLTQMYFFLLFGDL--DNF 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 550822324 159 TLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGL 202
Cdd:cd15918   90 LLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSL 133
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
77-347 1.03e-04

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 43.61  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  77 YSIVCVVGLFGNFLVMYVIVRY-TKMKTATNIYIFNLALADALATSTLPFqsVNYLMGTWPFG----TILCKIVISIDYY 151
Cdd:cd15129    7 YSVLLCLGLPVNILTAVALSRLaVRTKKSSYYYLLALTASDILTQVFIIF--VGFILQTAILArevpHALIHTVSVLEFA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMF---MATTKYRQGSIDCTLTFSHptw 228
Cdd:cd15129   85 ANHASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIPFYWwsdMWRDSHPPTTLDKVLKWTH--- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 ywenllkicVFIFAFImPVLIITVCYGLMILRLksvRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15129  162 ---------CFIIYFI-PCTIFLVTNSVIIHKL---RRRKGRSGPQRRSGKTTAILLAITTVFAVLWAPRTVVIIYHLYV 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 550822324 309 TiPETTFQTVSWHFCIA--LGYTNSCLNPVLYAFLDENFKR 347
Cdd:cd15129  229 S-SVNRDWRVHLALDLAnmLAMLNTAVNFFLYCFVSKRFRR 268
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
75-208 1.05e-04

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 43.86  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNM 153
Cdd:cd15420    5 GLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDiCYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALA 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550822324 154 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMA 208
Cdd:cd15420   85 HTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLL 139
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
76-349 1.51e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 43.33  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLpfqSVNYLMG---TWPFGTILCKIVISIDYYN 152
Cdd:cd15346    6 VFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAY---TANLLLSgatTYKLTPTQWFLREGSMFVA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCnWILSSAIG-LPVMFMATTKYRQgsiDCTLTFShptWYWE 231
Cdd:cd15346   83 LSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISAC-WVISLILGgLPIMGWNCISALS---SCSTVLP---LYHK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRM-----LSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKA 306
Cdd:cd15346  156 HYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLtfrknIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 550822324 307 LVTIPETTFQTVSWHFcIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15346  236 GCKVKTCSILFKAEYF-LVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
76-349 1.53e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 43.00  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVN-YLMGTW------PFGTILCKIVISI 148
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITiYLLNNRhlviedAFVRHIDNVFDSL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 149 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYrqgsidctltfshptw 228
Cdd:cd15354   86 ICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSESTY---------------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 ywenlLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSgSKEKDRNLRRITRMVLVVVAVF-----IVCWTPIHIYVI 303
Cdd:cd15354  150 -----VIICLITMFFAMLFLMVSLYIHMFLLARTHVKRIA-ALPGYNSVRQRTSMKGAVTLTIllgifIVCWAPFFLHLI 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 550822324 304 IkaLVTIPETTFQTV---SWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15354  224 L--MISCPQNLYCVCfmsHFNMYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
72-340 1.55e-04

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 43.16  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  72 TIMALYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALatsTLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15107    2 TMNFLSIIIALVGLAGNAIVLWLLG-FHMHRNAFSVYILNLAGADFL---FLCTQIVFSLEIVLQFHSIDIHIPLFLLTV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLC---TMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMfmattkyrqgsIDCTLTFSHPTW 228
Cdd:cd15107   78 TMFAYLAGLSmitAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLLSLLEG-----------KGCGFLFSTYDY 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 229 YWenlLKICVFIFAFIMPVLIITVCYGLMILRlksVRMLSGSKEKDrnLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 308
Cdd:cd15107  147 YW---CWTLDLITTAWLIVLFVVLSGSSLALL---VRIFCGSHRIP--VTRLYVTIALTVLVFLIFGLPFGIYWFLLKWI 218
                        250       260       270
                 ....*....|....*....|....*....|..
gi 550822324 309 TIPETTFQTVSWHFCIALGYTNSCLNPVLYAF 340
Cdd:cd15107  219 EEFYIVPCCGFYEVILFLSCVNSCANPIIYFL 250
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
74-339 1.72e-04

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 42.90  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  74 MALYSIVCVVGLFG---NFLVMYVIVRYTKMK-TATNIYIFNLALADALATS--TLPFQSVNYLMGTWPFGTILCKIVis 147
Cdd:cd15099    1 KAIAVLCFLAGPVTfleNILVLLTILSSTALRrRPSYLFIGSLALADMLASVifTISFLDFHVFHQRDSRNLFLFKLG-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 iDYYNMFT-SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMFMATTKYRQgsiDCTLTFSH 225
Cdd:cd15099   79 -GVTMAFTaSVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISfLPLMGWRCKTWDS---PCSRLFPY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 226 -PTWYWENLLKICVFIFAFIMpvliitVCYGLMILRLKS-VRMLSGSKEKDRNLRRITRM---------VLVVVAVFIVC 294
Cdd:cd15099  155 iDRHYLASWTGLQLVLLFLII------YAYPYILWKAHRhEANMGGPKLGRQQVKGQARMrmdirlaktLSLILLVLAIC 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 295 WTPIHIYVIIKALVTIpeTTFQTVSWHFCIALGYTNSCLNPVLYA 339
Cdd:cd15099  229 WLPVLAFMLVDVRVTL--TNKQKRMFAFCSMLCLVNSCVNPIIYA 271
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
76-174 2.46e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 42.63  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMG--TWPFGTILCKIVISIdyYN 152
Cdd:cd15232    6 LFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTvVPKLLQNLLTErkTISFGGCMAQLYFFT--WS 83
                         90       100
                 ....*....|....*....|..
gi 550822324 153 MFTSIFTLCTMSVDRYIAVCHP 174
Cdd:cd15232   84 LGSELLLLTAMAYDRYVAICHP 105
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
71-340 2.68e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 42.52  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKM-KTATNIYIFNLALADALATSTLPFQSVNY--LMGTWPFGTILCKIvis 147
Cdd:cd15341    1 IAIAVLCTLCGLLCILENVAVLYLILSSPKLrRKPSYLFIGSLALADFLASVVFACSFVDFhvFHGVDSSAIFLLKL--- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 148 iDYYNM-FT-SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIG-LPVMFMATTkyrQGSIDCTLTFs 224
Cdd:cd15341   78 -GGVTMsFTaSLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAyLPLMGWNCC---PLNSPCSELF- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 225 hPTWYWENLLKICVFIfAFIMPVLIITVCYGLMILRLKSVRMlsgSKEKDRNLRRITRM---------VLVVVAVFIVCW 295
Cdd:cd15341  153 -PLIPNDYLLSWLLLV-AILLSGIIYTYGHVLWKAHKHVVYM---EKHQDQQGPGNARMrldvrlaktLGLVLAVLLICW 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 550822324 296 TPIHIYVIIKALVTIPETTFQTVSwhFCIALGYTNSCLNPVLYAF 340
Cdd:cd15341  228 SPVLALMMHSLFTSLSDHIKKAFA--FCSTLCLVNSMVNPIIYAL 270
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
73-174 3.11e-04

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 42.54  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWPFGTILCKIVISIDYY 151
Cdd:cd15126    3 ILLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFfCLPVVVFNEITKKRLLGDVSCRVVPYMEVT 82
                         90       100
                 ....*....|....*....|...
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHP 174
Cdd:cd15126   83 SLGVTTFSLCALGIDRFHAATSP 105
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
75-202 4.64e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 41.82  E-value: 4.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTW--PFGTILCKIVISIDYY 151
Cdd:cd15235    6 LLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDiCFTSTTVPKMLANLLSGSKtiSYAGCLAQMYFFIAFG 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822324 152 NMFTsiFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGL 202
Cdd:cd15235   86 NTDS--FLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSL 134
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
79-176 5.08e-04

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 41.56  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCkiVISIDYYNMFTSI 157
Cdd:cd15951    9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDlVLSTSTLPKMLSIFWFNSREIDFSAC--LTQMFFIHSFSTM 86
                         90       100
                 ....*....|....*....|.
gi 550822324 158 FT--LCTMSVDRYIAVCHPVK 176
Cdd:cd15951   87 ESgiFVAMALDRYVAICNPLR 107
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
156-349 6.48e-04

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 41.38  E-value: 6.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 156 SIFTLCTMSVDRYIAVCHPVKaLDFRTP-RNAKIINVCNWILSSAIGLPVMFmATTKYRQGSIDCTLTFSHPtwywenlL 234
Cdd:cd15360   94 SVYTLTVITLERWHTITYAMQ-LDRKVRlRHAAVIMVGGWIFAFTVALLPIF-GISSYMKVSICLPMDIESP-------L 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 235 KICVFIFAFIMPVL---IITVCYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKA----L 307
Cdd:cd15360  165 SQAYIIFILVLNVLaflIICACYIKIYLTVRNPNFVSSNSDT-----KIAKRMAVLIFTDFLCMAPISFFAISASlkvpL 239
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 550822324 308 VTIPETTFQTVSWHfcialgYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15360  240 ITVSKSKILLVLFY------PINSCANPFLYAIFTKTFRRDF 275
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
75-349 7.61e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 40.92  E-value: 7.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAtstlpfqSVNYLMGTWPFGTILCKIVISIDYY--- 151
Cdd:cd15102    5 VVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLA-------GAAYLANILLSGARTLRLSPAQWFLreg 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFT----SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCnWILSSAIG-LPVMfmattkyrqgSIDCTLTFSHP 226
Cdd:cd15102   78 SMFValsaSVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGAC-WLISLLLGgLPIL----------GWNCLGALDAC 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 227 T----WYWENLLKICVFIFAFIMpvLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV 302
Cdd:cd15102  147 StvlpLYSKHYVLFCVTIFAGIL--AAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIACWGPLFILL 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 550822324 303 IIKALVTIPETTFqTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15102  225 LLDVACPVKTCPI-LYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
71-341 8.69e-04

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 40.89  E-value: 8.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIvRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtwPFGTI-LCKIVISID 149
Cdd:cd15106    1 LSLTFLTCIISLVGLTGNAVVLWLL-GFRMRRNAFSVYILNLAAADFLFLCCHIIDSLLRLIN--IFHIIsIPKILTNVM 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAttkyrqgsiDCTLTFSHPTWy 229
Cdd:cd15106   78 TFPYFAGLSMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSILEWKFC---------GFLFSGADSHW- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLlkicVFIFAFIMPVLIITVCYGLMILRlksVRMLSGSKEKDrnLRRITRMVLVVVAVFIVCWTPIHIYViikALVT 309
Cdd:cd15106  148 CQTF----DFITTAWLIFLFVVLCGSSLALL---VRILCGSRKMP--LTRLYVTILLTVLVFLLCGLPFGIQW---FLLL 215
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 550822324 310 IPETTFQTVSWHFCIA---LGYTNSCLNPVLYAFL 341
Cdd:cd15106  216 WIHIDLEVLFCHVYLVsvvLSCLNSSANPIIYFFV 250
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
82-349 1.23e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 40.23  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  82 VVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD----------ALATSTLPFQSVNYLMgTWPFGTiLCKIVISIDYY 151
Cdd:cd15359   12 ILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADfcmglyllliASVDSQTKSQYYNHAI-DWQTGS-GCSTAGFFTVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 152 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLpVMFMATTKYRQGSIDCTLTFSHPTWYWE 231
Cdd:cd15359   90 ASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAV-LPLVGVSNYMKVSICLPMDIETLLSQAY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 232 NLLKICVFIFAFimpvLIITVCYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIiKALVTIP 311
Cdd:cd15359  169 ILLILVLNVIAF----LVICACYIKIYLAVQNPELVAKNKDT-----KIAKRMAILIFTDFTCMAPISFFAI-SAAFKVP 238
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822324 312 ETTFqTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15359  239 LITV-TNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
88-340 1.28e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 40.15  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  88 NFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLpfqsVNYLMG---TWPFGTILCKIVISIDYYNMFTSIFTLCTM 163
Cdd:cd15349   18 NLLVLLAILRRVRLRRWVYICLANIALSDLLTgTSYL----VNICLSgerTFRLTPALWFLREGLLFTALAASTFSLLVT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 164 SVDRYIAVCHPV-KALDFRTPRNAKIINVCnWILSSAIG-LPVM-FMATTKYRQGSIDCTLtfshptwYWENLLKICVFI 240
Cdd:cd15349   94 AVERYATMVRPVaENTATKTYRVYGMIVLC-WILAFLIGfLPLLgWNCLCDFRSCSSLLPL-------YSKSYILFCLVI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 241 FAFIMpvLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTiPETTFQTVSW 320
Cdd:cd15349  166 FFIIL--LTIIGLYFAIYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCS-SRSCKPLFGM 242
                        250       260
                 ....*....|....*....|
gi 550822324 321 HFCIALGYTNSCLNPVLYAF 340
Cdd:cd15349  243 EWVLALAVLNSAINPLIYSF 262
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
71-176 2.13e-03

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 39.66  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15430    1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSsVPLMLVNFLSERKTISFSGCAVQMYLS 80
                         90       100
                 ....*....|....*....|....*..
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHPVK 176
Cdd:cd15430   81 LAMGSTECVLLAVMAYDRYVAICNPLR 107
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
71-176 2.46e-03

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 39.39  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG---TWPFgtILCKIVIS 147
Cdd:cd15428    1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSerkIISF--IRCAAQLY 78
                         90       100
                 ....*....|....*....|....*....
gi 550822324 148 IDYYNMFTSIFTLCTMSVDRYIAVCHPVK 176
Cdd:cd15428   79 FFLSFGITECALLSVMSYDRYVAICLPLR 107
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
75-174 2.75e-03

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 39.36  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  75 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATS-TLPFQSVNYLMGTWpfgtilckiviSIDYYN- 152
Cdd:cd15227    5 VLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISvTVPKSIANSLTNTR-----------SISFLGc 73
                         90       100       110
                 ....*....|....*....|....*....|..
gi 550822324 153 ----------MFTSIFTLCTMSVDRYIAVCHP 174
Cdd:cd15227   74 vaqvflfiffAASELALLTVMAYDRYVAICHP 105
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
71-174 3.70e-03

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 38.89  E-value: 3.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISID 149
Cdd:cd15416    1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDiCYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                         90       100
                 ....*....|....*....|....*
gi 550822324 150 YYNMFTSIFTLCTMSVDRYIAVCHP 174
Cdd:cd15416   81 ATFGTVECFLLAAMAYDRYVAICNP 105
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
79-348 3.87e-03

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 39.09  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  79 IVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQ---SVNYLMGTWPFGTILCKIVISIDYYNMF 154
Cdd:cd15006    8 VIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVcVPFDivlSASPHCCWWIYTLLFCKVIKFLHKVFCS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 155 TSIFTLCTMSVDRYIAVCHPVKaldfRTPRNAKIINVCNWILSSAI--GLPVMFMATTKYRQGSIDCTLTFSHPTWYWen 232
Cdd:cd15006   88 VTVLSFAAIALDRYYSVLYPLE----RKISDAKSRDLVIYIWAHAVvaSVPVFAVTNVTDIYAMSTCTESWGYSLGHL-- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 233 llkICVFIFAFIMPVLIITVCYGLMILrlkSVRMLSGSKEK-------------------DRNLRRITRMVLVVVAVFIV 293
Cdd:cd15006  162 ---VYVIIYNITTVILPVAVVFLFMIL---IRRALSASQKKkviiaalrtpqntisipyvSQREAELHAMLLSMVLVFIL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 550822324 294 CWTPIHIYVIIKALVTIPETT---FQTVSWHFCIALgytnsCLNPVLYAFLDENFKRC 348
Cdd:cd15006  236 CSVPYATLVIYRTILNISDISvflLLTAIWLPKVSL-----LANPLLFLTVNKSVRKC 288
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
71-174 5.46e-03

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 38.41  E-value: 5.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  71 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMG--TWPFGTILCKIVIS 147
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDiCYTTSTVPQMLVHLLSEhkTISFVGCAAQMFFF 80
                         90       100
                 ....*....|....*....|....*..
gi 550822324 148 IDYynMFTSIFTLCTMSVDRYIAVCHP 174
Cdd:cd15237   81 LAL--GVTECVLLAVMAYDRYVAICNP 105
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
88-349 6.58e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 38.08  E-value: 6.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  88 NFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSV-NYLMGTWPFGTILCKIVISidyyNMFTSIFTLCTMSVD 166
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLILNFIfAYLLQSEAAKLVTVGLIVA----SFSASVCSLLAITVD 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 167 RYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGL-PVMFMATTKYrqgsiDCTLTFSHPTWYWENLLKICVFIFAF-I 244
Cdd:cd15961   94 RYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLlPVMGWNCLAD-----ESTCSVVRPLTKNNAAILSVSFLLMFaL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 245 MPVLIITVCYglMILRLKSVRMLSG---SKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVswh 321
Cdd:cd15961  169 MLQLYIQICK--IVMRHAHQIALQHhflATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATL--- 243
                        250       260
                 ....*....|....*....|....*...
gi 550822324 322 fcIALGYtNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15961  244 --LPATY-NSIINPVIYAFRNQEIQKAL 268
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
76-209 8.18e-03

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 37.78  E-value: 8.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  76 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPfqsvnYLMGTWPFGTIlckiviSIDYYNMF 154
Cdd:cd15950    6 PFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDlVMSTSIVP-----KMLSIFWLGSA------EISFEACF 74
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550822324 155 TSIF-----------TLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAT 209
Cdd:cd15950   75 TQMFfvhsftavesgVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVT 140
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
73-349 9.39e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 37.48  E-value: 9.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324  73 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTlpFQSVNYLMGTWPFGTILCKIVI--SIDY 150
Cdd:cd15347    3 ASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVA--FIANILLSGSVTFRLTPVQWFIreGTAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 151 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCnWILSSAI-GLPVMFMATTKYRQgsiDCTLTFShptWY 229
Cdd:cd15347   81 ITLSASVFSLLAIAIERHVAITKVKLYGSDKNCRMVLLIGAC-WVISIVLgGLPILGWNCIGNLE---DCSTVLP---LY 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822324 230 WENLLKICVFIFAFIMpvLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITrmvlVVVAVFIVCWTPIHIYVIIKALVT 309
Cdd:cd15347  154 SKHYILFVVTIFSIIL--LSIVILYVRIYCIVRSSHAEMAAPQTLALLKTVT----IVLGVFIVCWLPAFIILLLDTSCK 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 550822324 310 IPETTFQTVSwHFCIALGYTNSCLNPVLYAFLDENFKRCF 349
Cdd:cd15347  228 VKSCPILYKA-DYFFSVATLNSALNPVIYTLRSKDMRKEF 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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