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Conserved domains on  [gi|548923870|ref|NP_001271308|]
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COMM domain-containing protein 4 isoform 4 [Homo sapiens]

Protein Classification

COMM domain-containing protein( domain architecture ID 4715)

COMM (copper metabolism gene MURR1) domain-containing protein is involved in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd super family cl06336
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 31-133 4.97e-63

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


The actual alignment was detected with superfamily member cd04752:

Pssm-ID: 471425 [Multi-domain]  Cd Length: 174  Bit Score: 190.72  E-value: 4.97e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923870  31 LSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 110
Cdd:cd04752    1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                         90       100
                 ....*....|....*....|...
gi 548923870 111 SLCRCYEEKQSPLQKHLRVCSLR 133
Cdd:cd04752   81 SLCRSYEEKQSKLQESLRANSLR 103
 
Name Accession Description Interval E-value
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 31-133 4.97e-63

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 190.72  E-value: 4.97e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923870  31 LSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 110
Cdd:cd04752    1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                         90       100
                 ....*....|....*....|...
gi 548923870 111 SLCRCYEEKQSPLQKHLRVCSLR 133
Cdd:cd04752   81 SLCRSYEEKQSKLQESLRANSLR 103
 
Name Accession Description Interval E-value
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 31-133 4.97e-63

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 190.72  E-value: 4.97e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923870  31 LSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 110
Cdd:cd04752    1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                         90       100
                 ....*....|....*....|...
gi 548923870 111 SLCRCYEEKQSPLQKHLRVCSLR 133
Cdd:cd04752   81 SLCRSYEEKQSKLQESLRANSLR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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