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Conserved domains on  [gi|548853196|gb|ERN11202|]
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hypothetical protein AMTR_s00024p00216120 [Amborella trichopoda]

Protein Classification

WDR46/Utp7 family WD40 repeat domain-containing protein( domain architecture ID 13236815)

WDR46/Utp7 family WD40 repeat domain-containing protein similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 7 that is involved in nucleolar processing of pre-18S ribosomal RNA, and Canis lupus familiaris WD repeat-containing protein 46, a scaffold component of the nucleolar structure

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042274|GO:0030490|GO:0003723
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 337-416 1.24e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


:

Pssm-ID: 462375  Cd Length: 79  Bit Score: 159.54  E-value: 1.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196  337 LYMSHrMLKGYQVGEVRFRPYEDVLGFGHSTGISSILVPGSGEPNFDTFVANPFETSKQRREKEVHALLDKLQPEMIMMD 416
Cdd:pfam08149   1 PYLTH-LLPGSTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-339 8.96e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 8.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 102 YVLDYTSNGHYMLVGGRRGHLAMMDVMSMNLIKEFQV-RETIRDVKFLHNDQFFAAAQK-KYSYIYN-KVGTEIHCLKEN 178
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSSdKTIRLWDlETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 179 LFP-LSLQFLQNYFLLVSINKYGQLLYQDTTTGEIV----GHhrtglgRCDVMNA--NPFNSVIALGHNSGKVTLWKPTS 251
Cdd:cd00200   93 TSYvSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttlrGH------TDWVNSVafSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 252 ANPLVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWDLRKFEAVHTFKGHAK---TLDFSQRGLLaMASGSL---IKI 325
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvnSVAFSPDGYL-LASGSEdgtIRV 245

                        250
                 ....*....|....
gi 548853196 326 WRDDSGNSDYQLYM 339
Cdd:cd00200  246 WDLRTGECVQTLSG 259
 
Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 337-416 1.24e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 159.54  E-value: 1.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196  337 LYMSHrMLKGYQVGEVRFRPYEDVLGFGHSTGISSILVPGSGEPNFDTFVANPFETSKQRREKEVHALLDKLQPEMIMMD 416
Cdd:pfam08149   1 PYLTH-LLPGSTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 337-416 1.08e-44

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 151.61  E-value: 1.08e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196   337 LYMSHRMlKGYQVGEVRFRPYEDVLGFGHSTGISSILVPGSGEPNFDTFVANPFETSKQRREKEVHALLDKLQPEMIMMD 416
Cdd:smart01033   1 PYMTHGL-PGSRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLD 79
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-339 8.96e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 8.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 102 YVLDYTSNGHYMLVGGRRGHLAMMDVMSMNLIKEFQV-RETIRDVKFLHNDQFFAAAQK-KYSYIYN-KVGTEIHCLKEN 178
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSSdKTIRLWDlETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 179 LFP-LSLQFLQNYFLLVSINKYGQLLYQDTTTGEIV----GHhrtglgRCDVMNA--NPFNSVIALGHNSGKVTLWKPTS 251
Cdd:cd00200   93 TSYvSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttlrGH------TDWVNSVafSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 252 ANPLVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWDLRKFEAVHTFKGHAK---TLDFSQRGLLaMASGSL---IKI 325
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvnSVAFSPDGYL-LASGSEdgtIRV 245

                        250
                 ....*....|....
gi 548853196 326 WRDDSGNSDYQLYM 339
Cdd:cd00200  246 WDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
104-327 7.25e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 7.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 104 LDYTSNGHYMLVGGRRGHLAMMDVMSMNLIKEFQV-RETIRDVKFLHNDQFFAAAqkkySY-----IYN-KVGTEIHCLK 176
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASG----SAdgtvrLWDlATGKLLRTLT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 177 -ENLFPLSLQFLQNYFLLVSINKYGQL-LYqDTTTGEIVGHHRTGLGRCDVMNANPFNSVIALGHNSGKVTLWKPTSANP 254
Cdd:COG2319  244 gHSGSVRSVAFSPDGRLLASGSADGTVrLW-DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 548853196 255 LVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWDLRKFEAVHTFKGHAK---TLDFSQRGLLAmASGSL---IKIWR 327
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGavtSVAFSPDGRTL-ASGSAdgtVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 251-290 2.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 548853196   251 SANPLVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWD 290
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
253-290 5.00e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 548853196  253 NPLVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWD 290
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 337-416 1.24e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 159.54  E-value: 1.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196  337 LYMSHrMLKGYQVGEVRFRPYEDVLGFGHSTGISSILVPGSGEPNFDTFVANPFETSKQRREKEVHALLDKLQPEMIMMD 416
Cdd:pfam08149   1 PYLTH-LLPGSTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 337-416 1.08e-44

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 151.61  E-value: 1.08e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196   337 LYMSHRMlKGYQVGEVRFRPYEDVLGFGHSTGISSILVPGSGEPNFDTFVANPFETSKQRREKEVHALLDKLQPEMIMMD 416
Cdd:smart01033   1 PYMTHGL-PGSRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLD 79
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-339 8.96e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 8.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 102 YVLDYTSNGHYMLVGGRRGHLAMMDVMSMNLIKEFQV-RETIRDVKFLHNDQFFAAAQK-KYSYIYN-KVGTEIHCLKEN 178
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSSdKTIRLWDlETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 179 LFP-LSLQFLQNYFLLVSINKYGQLLYQDTTTGEIV----GHhrtglgRCDVMNA--NPFNSVIALGHNSGKVTLWKPTS 251
Cdd:cd00200   93 TSYvSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttlrGH------TDWVNSVafSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 252 ANPLVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWDLRKFEAVHTFKGHAK---TLDFSQRGLLaMASGSL---IKI 325
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvnSVAFSPDGYL-LASGSEdgtIRV 245

                        250
                 ....*....|....
gi 548853196 326 WRDDSGNSDYQLYM 339
Cdd:cd00200  246 WDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
104-327 7.25e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 7.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 104 LDYTSNGHYMLVGGRRGHLAMMDVMSMNLIKEFQV-RETIRDVKFLHNDQFFAAAqkkySY-----IYN-KVGTEIHCLK 176
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASG----SAdgtvrLWDlATGKLLRTLT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 177 -ENLFPLSLQFLQNYFLLVSINKYGQL-LYqDTTTGEIVGHHRTGLGRCDVMNANPFNSVIALGHNSGKVTLWKPTSANP 254
Cdd:COG2319  244 gHSGSVRSVAFSPDGRLLASGSADGTVrLW-DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 548853196 255 LVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWDLRKFEAVHTFKGHAK---TLDFSQRGLLAmASGSL---IKIWR 327
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGavtSVAFSPDGRTL-ASGSAdgtVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
181-331 3.16e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 3.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 181 PLSLQFLQNYFLLVSINKYGQLLYQDTTTGEIVGHHRTGLGRCDVMNANPFNSVIALGHNSGKVTLWKPTSANPLVKMLC 260
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548853196 261 HHGPIAALAFHNNGHLMATAGMDHKIKLWDLRKFEAVHTFKGHAKT---LDFSQRG-LLAMASG-SLIKIWRDDSG 331
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvrsVAFSPDGkLLASGSAdGTVRLWDLATG 236
WD40 COG2319
WD40 repeat [General function prediction only];
182-331 5.28e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 5.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 182 LSLQFLQNYFLLVSINKYGQLLYQDTTTGEIVGHHRTGLGRCDVMNANPFNSVIALGHNSGKVTLWKPTSANPLVKMLCH 261
Cdd:COG2319   40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548853196 262 HGPIAALAFHNNGHLMATAGMDHKIKLWDLRKFEAVHTFKGHAK---TLDFSQRGLLaMASGSL---IKIWRDDSG 331
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGavtSVAFSPDGKL-LASGSDdgtVRLWDLATG 194
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 261-361 4.34e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 4.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 261 HHGPIAALAFHNNGHLMATAGMDHKIKLWDLRKFEAVHTFKGHA---KTLDFSQRGLLaMASGSL---IKIWRDDSGNsd 334
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvRDVAASADGTY-LASGSSdktIRLWDLETGE-- 84

                         90       100
                 ....*....|....*....|....*....
gi 548853196 335 yqlymSHRMLKGYQ--VGEVRFRPYEDVL 361
Cdd:cd00200   85 -----CVRTLTGHTsyVSSVAFSPDGRIL 108
WD40 COG2319
WD40 repeat [General function prediction only];
104-292 1.11e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 104 LDYTSNGHYMLVGGRRGHLAMMDVMSMNLIKEFQVRE-TIRDVKFLHNDQFFAAA-QKKYSYIYN-KVGTEIHCLKENLF 180
Cdd:COG2319  210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSgSVRSVAFSPDGRLLASGsADGTVRLWDlATGELLRTLTGHSG 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 181 P-LSLQFLQNYFLLVSINKYGQLLYQDTTTGEIVGHHRTGLGRCDVMNANPFNSVIALGHNSGKVTLWKPTSANPLVKML 259
Cdd:COG2319  290 GvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                        170       180       190
                 ....*....|....*....|....*....|...
gi 548853196 260 CHHGPIAALAFHNNGHLMATAGMDHKIKLWDLR 292
Cdd:COG2319  370 GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
206-331 1.56e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 206 DTTTGEIVGHHRTGLGRCDVMNANPFNSVIALGHNSGKVTLWKPTSANPLVKMLCHHGPIAALAFHNNGHLMATAGMDHK 285
Cdd:COG2319   22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 548853196 286 IKLWDLRKFEAVHTFKGHAK---TLDFSQRG-LLAMASG-SLIKIWRDDSG 331
Cdd:COG2319  102 VRLWDLATGLLLRTLTGHTGavrSVAFSPDGkTLASGSAdGTVRLWDLATG 152
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 251-290 2.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 548853196   251 SANPLVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWD 290
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
253-290 5.00e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 548853196  253 NPLVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWD 290
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 104-290 1.26e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 104 LDYTSNGHYMLVGGRRGHLAMMDVMSMNLIKEFQ-VRETIRDVKFLHNDQF-FAAAQKKYSYIYNkvGTEIHCLKENLFP 181
Cdd:cd00200   99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFvASSSQDGTIKLWD--LRTGKCVATLTGH 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548853196 182 ----LSLQFLQNYFLLVS------INKYGqlLYQDTTTGEIVGHhrtgLGRCDVMNANPFNSVIALGHNSGKVTLWKPTS 251
Cdd:cd00200  177 tgevNSVAFSPDGEKLLSsssdgtIKLWD--LSTGKCLGTLRGH----ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 548853196 252 ANPLVKMLCHHGPIAALAFHNNGHLMATAGMDHKIKLWD 290
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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