|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
38-438 |
7.12e-144 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 416.74 E-value: 7.12e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 38 VAWVLNYLDRVNISFAQVYLKHDLGMSDADLRTRRKLVFHRLHRIGNTQYAYLQKIGARLTITRIMVLWGLISASMAFMT 117
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 118 TPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFVdvmgmknWQWMFIL 197
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFS-------WQWAFII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 198 EGLPAAVMGVMAYFYLVDKPEQAKWLDDEEKSIILDALAADRAGKKPVTDKRHAVLAALKDPRVYVLAAGWATVPLCGTI 277
Cdd:TIGR00893 154 EGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 278 LNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDIRLERRKHFFFSIAFGALG---ACLLPHVVDSAIISI 354
Cdd:TIGR00893 234 FLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAglvLSLLMFATNYVNIPY 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 355 TCLAMIAVSYFG--AAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAPIGLGWINTVTGSLAIGLTIIGALVLAGGM 432
Cdd:TIGR00893 314 AALALVALGFFGlgAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGAL 393
|
....*.
gi 548511 433 AVLIAV 438
Cdd:TIGR00893 394 SYLLLV 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-436 |
3.93e-89 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 275.22 E-value: 3.93e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 29 TLRLMTFIFVAWVLNYLDRVNISFAQVYLKHDLGMSDADLRTRRKLVFHRLHRIGNTQYAYLQKIGARLTITRIMVLWGL 108
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 109 ISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFvdvmgm 188
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 189 kNWQWMFILEGLPAAVMGVMAYFYLvdkpeqakwlddeeksiildalaadragkkpvtdkrhavlaalkdPRVYVLAAGW 268
Cdd:cd17319 155 -GWRWAFIIEGLLGLLLAVLWWFYL---------------------------------------------RQVWGLALGY 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 269 ATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSD--IRLERRKHFFFSIAFGALGACLLPHv 346
Cdd:cd17319 189 FGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrlLRGARRLVIIIGLLLAAVGLLLAYL- 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 347 VDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAPIGLGWINTVTGSLAIGLTIIGAL 426
Cdd:cd17319 268 TTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAV 347
|
410
....*....|
gi 548511 427 VLAGGMAVLI 436
Cdd:cd17319 348 ALLAALLVLL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-439 |
2.24e-46 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 164.27 E-value: 2.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 22 EKVYRKVTLRLMTFIFVAWVLNYLDRVNISFAQVYLKHDLGMSDADLrtrrKLVFhrlhriGNTQYAY----------LQ 91
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL----GLLA------SAFFLGYalgqipagllAD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIG 171
Cdd:COG2271 71 RFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 172 GPLSGWILTHFvdvmgmkNWQWMFILEGLPAAVMGVMayfylvdkpeqakwlddeeksiildalaadragkkpvtdkrha 251
Cdd:COG2271 151 PPLLGWLLAAF-------GWRAAFLILGLPGLLLALL------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 252 vlaalkdpRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDIRLERRKHFFF 331
Cdd:COG2271 181 --------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 332 SIAFGALGACLLPHVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAPIGLGWINT 411
Cdd:COG2271 253 IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
410 420
....*....|....*....|....*...
gi 548511 412 VTGsLAIGLTIIGALVLAGGMAVLIAVP 439
Cdd:COG2271 333 ATG-YQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
27-403 |
6.43e-44 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 158.57 E-value: 6.43e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 27 KVTLRLMTFIFVAWVLNYLDRVNISFAQVY-LKHDLGMSDADLRTRRKlVFHRLHRIGNTQYAYL-QKIGARLTITRIMV 104
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNT-VFYVGYIIFELPGNLLlQRFPPSKWLSVFIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 105 LWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSrFLLAIAAAGIIGGPLSGWILTHFVD 184
Cdd:cd17327 80 LWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIA-FFYAAAGLGSIFGGLLAYGVFKILG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 185 VMGMKNWQWMFILEGLPAAVMGVMAYFYLVDKPEQAKWLDDEEKSIILDALAADRAGKKPVTDKRHAVLAALKDPRVYVL 264
Cdd:cd17327 159 VGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 265 AAGWATVPLCGTILNYWTPTIIRNTGiQDVLHVGLLSTVPYIVGAIAMILIARSSDIRLERRKHFFFSIAFGALGACLLP 344
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPLILKSLG-FYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 548511 345 HVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAP 403
Cdd:cd17327 318 AAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-436 |
4.28e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 136.93 E-value: 4.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 31 RLMTFIFVAWVLNYLDRVNISFAQVYLKHDLGMSDAD--------------LRtrrkLVFHRLhrigntqyayLQKIGAR 96
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQlgllfaipvlvgalLR----IPLGFL----------VDRFGPR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 97 LTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSG 176
Cdd:COG2223 71 RVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 177 WILTHFvdvmgmkNWQWMFILEGLPAAVMGVMAYFYLVDKPEQAkwlddeeksiildalaadragKKPVTDKRHAVLAAL 256
Cdd:COG2223 151 LLIAAF-------GWRNAFLILGILLLVVAVLAWLFLRDPPAGA---------------------AAAAKASLRDQLEAL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 257 KDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDiRLERRKHFFFSIAFG 336
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD-RIGGRRVLLIVFALM 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 337 ALGACLLPHVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAPIGLGWINTVTGSL 416
Cdd:COG2223 282 ALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSY 361
|
410 420
....*....|....*....|
gi 548511 417 AIGLTIIGALVLAGGMAVLI 436
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLL 381
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-435 |
7.15e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 96.73 E-value: 7.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 36 IFVAWVLNYLDRVNISFAQVYLKHDLGMSDADLRTRRkLVFHRLHRIGNTQYAYL-QKIGARLTITRIMVLWGLISASMA 114
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLF-ALFSLGYALLQPLAGLLaDRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 115 FMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFVdvmgmKNWQWM 194
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-----FGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 195 FILEGLPAAVMGVMAYFYLVDKPEQAKWLDDEEKSiildalaadragkkpvTDKRHAVLAALKDPRVYVLAAGWATVPLC 274
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESARAKNEEASS----------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 275 GTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDIRLERRKHFFFSIAFGALGACLLPHvVDSAIISI 354
Cdd:cd06174 219 YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL-APSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 355 TCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAPIGLGWINTVTGSLAIGLTIIGALVLAGGMAV 434
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
.
gi 548511 435 L 435
Cdd:cd06174 378 L 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
91-403 |
5.88e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.86 E-value: 5.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 91 QKIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGII 170
Cdd:pfam07690 57 DRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAAL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 171 GGPLSGWILTHFvdvmgmkNWQWMFILEGLPAAVMGVMAYFYLVDKPEQAKwlddeeksiildalaadrAGKKPVTDKRH 250
Cdd:pfam07690 137 GPLLGGLLASLF-------GWRAAFLILAILSLLAAVLLLLPRPPPESKRP------------------KPAEEARLSLI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 251 AVLAALKDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLhVGLLSTVPYIVGAIAMILIARSSD-IRLERRKHF 329
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALL-AGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLL 270
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 548511 330 FFSIAFGALGACLLPHVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAP 403
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
92-399 |
4.84e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 85.03 E-value: 4.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIG 171
Cdd:COG2814 71 RFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 172 GPLSGWILTHFvdvmgmkNWQWMFILEGLPAAVMGVMAYFYLVDKPEQAKwlddeeksiildalaadragkkpvTDKRHA 251
Cdd:COG2814 151 PLLGGLLADLF-------GWRWVFLVNAVLALLALLLLLRLLPESRPAAR------------------------ARLRGS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 252 VLAALKDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDiRLERRKHFFF 331
Cdd:COG2814 200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD-RFGRRRLLLI 278
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548511 332 SIAFGALGACLLPhVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGA 399
Cdd:COG2814 279 GLLLLALGLLLLA-LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
92-435 |
1.55e-15 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 77.64 E-value: 1.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIG 171
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 172 GPLSGWILTHFVDVMGmknWQWMFILEGLPAAVMGVMAYfylvdkpeqakwlddeeksiildalaadragkkpvtdkrha 251
Cdd:cd17316 142 ALVASLLIPLLSGDWG---WRILFLIGALPALLALLLRR----------------------------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 252 vlaalkdpRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDiRLERRKHFFF 331
Cdd:cd17316 178 --------RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD-RIGRKKTLVI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 332 SIAFGALGACLLP-HVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAPIGLGWIN 410
Cdd:cd17316 249 GLILSGILALPLFyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLL 328
|
330 340
....*....|....*....|....*
gi 548511 411 TVTGSLAIGLTIIGALVLAGGMAVL 435
Cdd:cd17316 329 ASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
26-435 |
9.43e-15 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 75.39 E-value: 9.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 26 RKVTLRLMTFIFVAWvlnYLDRVNISFAQVYLKHDLGMSDADLRTrrklvfhrlhrIGNTQ---YAYLQKI----GARLT 98
Cdd:cd17312 1 RWRIFLGVFLGYAAY---YVCRKNFSVAKPPIVEEIGLSKDDLGI-----------IGSAFliaYAVGKFIsgflSDRSN 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 99 ITRIM----VLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPL 174
Cdd:cd17312 67 IRRFMsaglLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPIL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 175 SGWILTHFvdvmgmkNWQWMFILEGLPAAVMGVMAYFYLVDKPeqakwlddeeksiildalaadragkkpvtdkrhavla 254
Cdd:cd17312 147 AASLASYY-------GWRAAFLVPGIVGLVVAIILFFFLRDSP------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 255 alkdPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSD--IRLERRKHFFFS 332
Cdd:cd17312 183 ----PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDklFGGRRAPIAVIY 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 333 IAFGALGACLLPHVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSL-GQIGAFCAPIGLGWINT 411
Cdd:cd17312 259 MLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLfGYLGASLAGLPLGYIID 338
|
410 420
....*....|....*....|....
gi 548511 412 VTGSLAIGLTIIGALVLAGGMAVL 435
Cdd:cd17312 339 HYGWSTVFYFLISAALLSVLLLLS 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
92-438 |
4.34e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.30 E-value: 4.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIG 171
Cdd:cd17325 57 RFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 172 GPLSGWILTHFVdvmgmknWQWMFILEGLPAAVMGVMAYFYLVDKPEQAKwlddeeksiildalaadrAGKKPVTDKRHA 251
Cdd:cd17325 137 PLLGGLLADALG-------YRAPFLVCAALALLALVLALLLLPEPRPPPN------------------KRAVSAARLRSG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 252 VLAALKDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDiRLERRKHFFF 331
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD-RIGRKPLILI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 332 SIAFGALGACLLPhVVDSAIISITCLAMIAVSYfgaaAIIWSIPPAYLNDESAAGG----ISAISSLGQIGAFCAPIGLG 407
Cdd:cd17325 271 GLLLSAVALLLLP-LATSFWLLLLLLALLGLGL----GLVFPATLALLADIVPPEGrgtaMGLFNTAFSLGMVLGPLLGG 345
|
330 340 350
....*....|....*....|....*....|.
gi 548511 408 WINTvTGSLAIGLTIIGALVLAGGMAVLIAV 438
Cdd:cd17325 346 FLYD-AFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
37-414 |
2.02e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 68.17 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 37 FVAWVLNYLDRVNISFAQVYLKHDLGMSDADLRTRRKLvFHRLHRIGNTQYAYL-QKIGARLTITRIMVLWGLISASMAF 115
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSS-FSIAYGISKFVMGSVsDRSNPRVFLPIGLILCAIVNLFFGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 116 MTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFVDvmgmknWQWMF 195
Cdd:TIGR00881 80 STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYS------WHWVF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 196 ILEGLPAAVMGVMAYFYLVDKPEQAKWLDDEEKSIilDALAADRAGKKPVTDKRHAVLA-ALKDPRVYVLAAGWATVPLC 274
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPN--EEPDGDAEKKEEELTKKQIFLQyVLLNKVLWYISLGYVFVYVV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 275 GTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDIRLERRKH---FFFS--IAFGALGACLLPhvVDS 349
Cdd:TIGR00881 232 RTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGplaVFFMalIIVSLLVYWLNP--AAN 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548511 350 AIISITCLAMIAVSYFGAAAIIWSIpPAYLNDESAAGGISAISSL-GQIGAFCAPIGLGWINTVTG 414
Cdd:TIGR00881 310 PLMDLICLFALGFLVYGPQMLIGVI-ASELAPKKAAGTAAGFVGFfAYLGGILAGLPLGYLADGFG 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
91-437 |
5.89e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.21 E-value: 5.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 91 QKIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPgARRARITSRFLLAIAAAGII 170
Cdd:COG2807 78 RRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAAL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 171 GGPLSGWILTHFvdvmgmkNWQWMFILEGLPAAVMGVMayfylvdkpeqakWLddeeksiildALAADRAGKKPVTDKRH 250
Cdd:COG2807 157 AAGLTVPLAAAL-------GWRGALAVWALLALLALLL-------------WL----------PLLRRRPAAAAAAPAAA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 251 AVLAALKDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIqDVLHVGLLSTVPYIVGAIAMILIARSSDIRLERRKHFF 330
Cdd:COG2807 207 SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGL-SAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 331 FSIAFGALGACLLphVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAIS-SLGQIGAFCAPIGLGWI 409
Cdd:COG2807 286 LLGLLGLAGLLGL--LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAqSVGYLLAALGPLLVGAL 363
|
330 340
....*....|....*....|....*...
gi 548511 410 NTVTGSLAIGLTIIGALVLAGGMAVLIA 437
Cdd:COG2807 364 HDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
92-435 |
5.84e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.83 E-value: 5.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAG-FWPGIILYLTYWYPGARRARITSRFLLAIAAAGII 170
Cdd:cd17355 64 RFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 171 GGPLSGWILTHFvdvmgmkNWQWMFILEGLPAAVMGVMAYFYLVDKPEqakwlddeeksiiLDALAADRAGKKPVTdkRH 250
Cdd:cd17355 144 FLPLGAALIEAF-------GWRTALLVLALLALLVLVPVLLLLRRRPA-------------DLALRAYDDASPASP--GS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 251 AVLAALKDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVpYIVGAIAMILIARSSDiRLERRKHFF 330
Cdd:cd17355 202 TLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALI-GLFNIVGRLLSGWLGD-RYSPRRLLA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 331 FSIAFGALGACLLPHVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAPIGLGWIN 410
Cdd:cd17355 280 ASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359
|
330 340
....*....|....*....|....*
gi 548511 411 TVTGSLAIGLTIIGALVLAGGMAVL 435
Cdd:cd17355 360 DRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
92-439 |
4.85e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 54.62 E-value: 4.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWP-GIILYLTYWyPGARRARITSRFLLAIAAAGII 170
Cdd:cd17371 60 RFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAaGAALMAEYV-PARHRGKALGYVQSGWAVGWLL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 171 GGPLSGWILTHFVDVMGmknWQWMFILEGLPAAVMGVMAYFYlvdkPEQAKWLDdeeksiildalaadrAGKKPVTDKRH 250
Cdd:cd17371 139 ATLLAALLFPLLPPEIA---WRVLFLLGALPALLVLFIRRFV----KEPPQWQA---------------ARAARRHFADR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 251 AVLAALKDPRVYVLAAGWaTVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPY----IVGAIAMILIARSSDIRLERR 326
Cdd:cd17371 197 PSLRELFSPPLLRTTLLA-SLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYlvvtILGGFLGYLAGGFLADRIGRR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 327 khffFSIAFGALGACL-------LPHVVDSAIISITCLAMIAVSYFGAAAIIWS--IPPAYlndesAAGGISAISSLGQI 397
Cdd:cd17371 276 ----NNFALFALGSAIsillyffLPLSPTLILILGFPLGFFASGPFSGMGAYLTelFPTAV-----RATAQGFCYNVGRI 346
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 548511 398 GAFCAPIGLGWINTvTGSLAIGLTIIGALVLAGGMAVLIAVP 439
Cdd:cd17371 347 IGALFPFLVGFLAT-SGSLGTAIAVFAAVYYIAGLVLALLLP 387
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
103-438 |
4.89e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.89 E-value: 4.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 103 MVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRfllaiaaaGIIGGPLSGWILTHF 182
Cdd:cd17473 72 LLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL--------QSAAMSLGGVVFLLL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 183 VDVMGMKNWQWMFILEGLpAAVMGVMAYFYLVDKPEQakwlddeeksiildalaadragKKPVTDKRHAVLAALKDPRVY 262
Cdd:cd17473 144 GGALAEIGWRAPFLVYLL-ALPVLILVLLFLPEPARK----------------------SKSAASPGAATAAALPWKRVL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 263 VLAAgwatVPLCGTILNYWTPT----IIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDiRLERRKHFFFSIAFGAL 338
Cdd:cd17473 201 PIYF----LAFLAMLLFYVIPIqlpfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKR-RLGKRRLLAIGFALMAL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 339 GACLLPHVVDSAIISITC-LAMIAVSYFGAAAIIWSIppAYLNDESAAGGISAISSLGQIGAFCAPIGLGWINTVTGSLA 417
Cdd:cd17473 276 GFLLLALASGLWVVLLGAiLAGLGFGLLLPTLNSWAM--SLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLS 353
|
330 340
....*....|....*....|.
gi 548511 418 igltiiGALVLAGGMAVLIAV 438
Cdd:cd17473 354 ------GAFLILGVLALVLAI 368
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
36-369 |
2.16e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.01 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 36 IFVAWVLNYLDRVNISFAQVYLKHDLGMSDAD---LRTRRKLVFHRLHRIgntqYAYLqkiGARLTITRIMV----LWGL 108
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLaglLQTVFIISYMVLSPI----FGYL---GDRYNRKWILAvgilIWSA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 109 ISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFVDvmgm 188
Cdd:cd17328 77 ATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGG---- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 189 knWQWMFILEGLPAAVMGVMAYFYLVDKPEQAkwlddeeksiildalAADRAGKKPVTDKRHAVLAALKDPRVYVL-AAG 267
Cdd:cd17328 153 --WRWAFRVTGVLGVLLAILLLLFVREPPRGA---------------AEGGVMAKSTATSFLADLKALAKNPSFILsTLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 268 WATVPLCGTILNYWTPT---IIRNTGIQDVLHVGL-LSTVPYIVGAIAMILIARSSD-IRLERRKHFFFSIAFGALGA-- 340
Cdd:cd17328 216 FTAVSFVTGALAFWAPTfflRAFGVGDLSSADVGLiFGAITCIAGVLGVLLGGILADrLRRKTPRADPLVCAVGLLAAap 295
|
330 340
....*....|....*....|....*....
gi 548511 341 CLLPHVVDSAIISITCLAMIAVSYFGAAA 369
Cdd:cd17328 296 FLFLALVLALSNLLLAWVLLFLGEFLLSL 324
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
94-429 |
4.38e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.87 E-value: 4.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 94 GARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIIlYLTYWYPGarraRITSRFLLAIAAAGIIGGP 173
Cdd:cd17341 63 GRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGANFASGQP-WASFWFPK----EKIGGAAGGIAGAGNMGVA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 174 LSG----WILTHFVDVMGMKNWQWMFILEGLPAAVMGVMAYFYLVDKPEqakwlddeeksiildalaadraGKKPVTDKR 249
Cdd:cd17341 138 VSQllapLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPT----------------------GKASALEFL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 250 HAVLAALKDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDIRLERRKHF 329
Cdd:cd17341 196 KVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLW 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 330 F-FSIAFGALGACLLPHVVDSAIISITCLAMIAVSYF---GAAAIIWSIPPAYLNDESAAGGIsaISSLGQIGAFCAPIG 405
Cdd:cd17341 276 WlFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGagaGNGSVFRMVPFIFRRELGAVTGL--VGAIGGLGGFFLPLL 353
|
330 340
....*....|....*....|....
gi 548511 406 LGWINTVTGSLAIGLTIIGALVLA 429
Cdd:cd17341 354 FGSSALMTGSGVGAFSLFGVLAVA 377
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
92-409 |
1.11e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.43 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIG 171
Cdd:TIGR00895 78 RIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 172 GPLSGWILTHFvdvmgmkNWQWMFILEGLPAAVMGVMAYFYLvdkPEQAKWL---DDEEKSIILDALAADR--------A 240
Cdd:TIGR00895 158 GFLAGWLIPVF-------GWRSLFYVGGIAPLLLLLLLMRFL---PESIDFLvskRPETVRRIVNAIAPQMqaeaqsalP 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 241 GKKPVTDKRHAVLAALKDPR----VYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVpYIVGAIAMILIA 316
Cdd:TIGR00895 228 EQKSTQGTKRSVFKALFQGKtariTVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALF-NFGGVIGSIIFG 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 317 RSSDiRLERRKHFFFSIaFGALGACLLPHVVDSAIISITCLAMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQ 396
Cdd:TIGR00895 307 WLAD-RLGPRVTALLLL-LGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGR 384
|
330
....*....|...
gi 548511 397 IGAFCAPIGLGWI 409
Cdd:TIGR00895 385 LGAIIGPILAGYL 397
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
92-429 |
1.74e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIG 171
Cdd:cd17324 60 RIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 172 GPLSGWILTHFvdvmgmkNWQWMFILEGLPAAVMGVMAYFYlvdkpeqakwlddeeksiildaLAADRAGKKPVTDKRHA 251
Cdd:cd17324 140 RPLGGLLGQLL-------GWRAAFLAIAVLALLAALLLWRL----------------------LPSLPPKKPGSLGLLSS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 252 VLAALKDPRVYVLAAGWATVPLCGTIL-NYWTPTIIRNTGIQDVLHVGLLSTVpYIVGAIAMILIARSSDiRLERRKHFF 330
Cdd:cd17324 191 LLLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSAIIGLLLLF-GVAGVVGSPLAGRLAD-RGGRRALLI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 331 FSIAFGALGACL-LPHVVDSAIISITCLAMIAVSYFGAAAIIWSippAYLNDESAAGGISAISSLGQIGAFCAPIGLGWI 409
Cdd:cd17324 269 ALLLLAAALLLLtLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV---LRLAPEARGLASSLYLAAYNLGGALGAALGGLV 345
|
330 340
....*....|....*....|
gi 548511 410 NTVTGSLAIGLTIIGALVLA 429
Cdd:cd17324 346 LDHGGWAGVGWVGAALLLLA 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
92-316 |
1.02e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.11 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 92 KIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSrFLLAIAAAGIIG 171
Cdd:COG0477 75 RYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALG-LWGAAIGLGLAL 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 172 GPLSGWILTHFVDvmgmknWQWMFILEGLPAAVMGVMAYFYLVDKPEQAKWLDDEEKSIILDALAADRAGKKPVTDKRHA 251
Cdd:COG0477 154 GPLLGGLLVAALG------WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLL 227
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548511 252 VLAALKDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIA 316
Cdd:COG0477 228 ALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
100-409 |
1.34e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 47.23 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 100 TRIMVLWGLISASMAFMTTP-------TEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGG 172
Cdd:cd17318 85 AKRVLGYSILITALLTLLTPlaarggyGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAM 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 173 PLSGWILTHFvdvmgmkNWQWMFILEGLpAAVMGVMAYFYLVdkpeqakwlddeeksiildalaadragkkpvtdkrhav 252
Cdd:cd17318 165 PLSGFLCESL-------GWPSIFYIFGG-LGLLWCLLWFFLV-------------------------------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 253 laalkdPRVYVLAAGwatvpLCGTILNYWTPTIIRNTGIQDVLHV-----GLLSTVPYIVGAIAMILIARSSDIrLERRK 327
Cdd:cd17318 199 ------LPVWAIVVA-----HFGHNWGFYTLLTELPTYMSDVLHFniksnGFLSSLPYLAMWICSIVGGYLADW-LRSRG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 328 HF--------FFSIAFGALGACL--LPHVVDSAIISITCL----AMIAVSYFGAAAIIWSIPPAYlndesaAGGISAIS- 392
Cdd:cd17318 267 ILstttvrklFTSIGFLGPGVFLiaLGYLGSNATLAVVFLtlsvGLSGACYSGFLVNHLDLAPNY------AGTLMGITn 340
|
330
....*....|....*..
gi 548511 393 SLGQIGAFCAPIGLGWI 409
Cdd:cd17318 341 TAATIAGIISPLIVGAI 357
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
36-218 |
1.77e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 43.77 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 36 IFVAWVLNYLDRVNISFAQVYLKHDLGMSDADLRTRrKLVFHRLHRIGNTQYAYL-QKIGARLTITRIMVLWGLISASMA 114
Cdd:cd17345 8 IFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLI-GSALSIAYGLSKFVMGNLsDRSNPKRFLAIGLILSAIINILIG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 115 F----MTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFvdvmGMKN 190
Cdd:cd17345 87 FvpsaTSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIF----GDGW 162
|
170 180
....*....|....*....|....*...
gi 548511 191 WQWMFILEGLPAAVMGVMAYFYLVDKPE 218
Cdd:cd17345 163 WRGAFIFPAIIAIIVAVIVLFLGKDTPE 190
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
261-447 |
2.52e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 261 VYVLAAGWATVPLCGTILNYWTPTIIRNTGIqDVLHVGLLSTVPYIVGAIAMILIARSSDiRLERRKHFFFSIAFGALGA 340
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGA-SPAQAGLVVTAYLLGAALGAPLAGRLAD-RFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 341 CLLPhVVDSAIISITCLAMIAVsyfgAAAIIWSIPPAYLND----ESAAGGISAISSLGQIGAFCAPIGLGWINTVTGSL 416
Cdd:COG2814 90 LLCA-LAPSLWLLLAARFLQGL----GAGALFPAALALIADlvppERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190
....*....|....*....|....*....|.
gi 548511 417 AIgLTIIGALVLAGGMAVLIAVPANALSEKP 447
Cdd:COG2814 165 WV-FLVNAVLALLALLLLLRLLPESRPAARA 194
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
126-409 |
3.33e-04 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 42.81 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 126 RALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFVdvmgmkNWQWMFILEGLPAAVM 205
Cdd:TIGR00894 138 RVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWG------GWPMIFYVFGIVGCAW 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 206 GVMAYFYLVDKPEQAKWLDDEEKSIILDALAADRAGKKPVTdkrhAVLAALKDPRVYVLAAGWATVPLCGTILNYWTPTI 285
Cdd:TIGR00894 212 SLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTRQSL----PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTF 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 286 irntgIQDVLHV-----GLLSTVPYIVGAIAMILIARSSDIRLERR-------KHFFFSIAF---GALGACLLphVVDSA 350
Cdd:TIGR00894 288 -----ISWVLRVsgkenGLLSSLPYLFAWLCSIFAGYLADFLKSSKtlsltaaRKIFNGIGGlgpGIFAYALP--YLSAA 360
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548511 351 IISITCLAMIAVS-----YFGAAAIIWSIPPAYLndesaaGGISAISSL-GQIGAFCAPIGLGWI 409
Cdd:TIGR00894 361 FYLTIIILTLANAvssgpLAGVLINSLDLAPRFL------GFIKGITGLpGFIGGLIASTLAGNI 419
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
176-439 |
7.03e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 176 GWILTHFVDVMGMKNWQWMFILEGLPAAVMGVMAYFYLVDKPEQAkwlddEEKSIILDAlaadragkkpvtdkrhavLAA 255
Cdd:COG2211 167 PPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPE-----EEKVSLKES------------------LKA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 256 LKDPRVYVLaagwatvpLCGTILNYWTPTIIRNTG----IQDVLH-----VGLLSTVPYIVGAIAMILIARSSDiRLERR 326
Cdd:COG2211 224 LLKNRPFLL--------LLLAYLLFFLALALVAALllyyFKYVLGlsaalVGLLLALYFLAALLGAPLWPRLAK-RFGKK 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 327 KHFFFSIAFGALGACLLPHVVDSAIISItcLAMIAVSYFGAAAiIWSIPPAYLND----------ESAAGGISAISSLGQ 396
Cdd:COG2211 295 KAFIIGLLLAALGLLLLFFLGPGNLWLL--LVLAALAGIGLGA-ILVLPWAMLADvvdydewktgRRREGLYFGIFTFAI 371
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 548511 397 -----IGAFCAPIGLGWINTVTGS---------LAIGLTIIGALVLAGGMAVLIAVP 439
Cdd:COG2211 372 klgqaLAGALAGLLLALFGYVAGAaqspsaltgIRLLFFLLPAVLLLLAALLLLFYP 428
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
37-427 |
1.13e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 37 FVAWVLNYLDRVNISFAQVYLKHDLGMSDADLRTRRKLVFhrlhrIG--NTQYA--YL-QKIGARLTITRIMVLWGLISA 111
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFF-----WGyaLTQVLggYLaDRFGGKKVLLLAVALWSLATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 112 --SMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRAR----ITSRFLLAIAaagiiggpLSGWILTHFVDv 185
Cdd:cd17380 80 ltPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRavsiVTAGSYLGTL--------LGGLIGPLLLE- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 186 mgMKNWQWMFILEGLPAAVMGVMAYFYLVdkpeqakwlddeeksiildalaadragkkpvtdkrhAVLAALkdprVYVLA 265
Cdd:cd17380 151 --YYGWPSVFYFFGLLGLLWALVWLIYLP------------------------------------PVWAII----VAHFC 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 266 AGWATvplcgTILNYWTPTIIrNTGIQDVLHVGLLSTVPYIVGAIAMI--------LIARSSDIRLERRkhFFFSIAFG- 336
Cdd:cd17380 189 MNWGF-----YILLSWLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNvagwladhLISRGWTVTSVRK--LMQSIGFLg 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 337 -ALGACLLPHvVDSAIISITCLAM-IAVSYFGAAAIIWS---IPPAYlndesaAGGISAIS-SLGQIGAFCAPIGLGWIN 410
Cdd:cd17380 261 pALFLLLLSH-TDSFSLALLCMSVaLGLSAFSSSGVLVNhqdIAPNY------AGIVFGISnTAGTIPGIVGVYLTGYIL 333
|
410 420
....*....|....*....|...
gi 548511 411 TVTGS------LAIGLTIIGALV 427
Cdd:cd17380 334 EATGSwslvfvLAAVVNLVGAVV 356
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
278-436 |
1.58e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.65 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 278 LNYWTPTIIRNTGIQdvLHVGLLSTVPYIVGAIAMILIARSSDIRLERRKHFFFSIAFGALGACLLPHVVDSAIISITCL 357
Cdd:cd17365 190 LNSWLPKLMVEAGYS--LSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLV 267
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 548511 358 AMIAVSYFGAAAIIWSIPPAYLNDESAAGGISAISSLGQIGAFCAPIGLGWINTVTGSLAIGLTIIGALVLAGGMAVLI 436
Cdd:cd17365 268 FLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLL 346
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
90-436 |
4.71e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.07 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 90 LQKIGARLTITRIMVLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGi 169
Cdd:COG0738 67 IDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGAL- 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 170 iggpLSGWILTHFVDVMGMKNWQWMFILEGLPAAVMGVMAYFYLVDKPEQAKwlddeeksiildalaadragkKPVTDKR 249
Cdd:COG0738 146 ----LGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE---------------------EEAAGSA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 250 HAVLAALKDPRVYVLAAGWATVPLCGTILNYWTPTIIRNTGIQDVLHVGLLSTVPYIVGAIAMILIARSSDiRLERRKHF 329
Cdd:COG0738 201 ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK-RFGPVRLL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 330 FFSIAFGALGACLLPhVVDSAIISITCLAMIAvsyFGAAAI---IWSIPPAYLNDESAAGgISAISSLGQIGAFCAPIGL 406
Cdd:COG0738 280 RLSALLAAVGLLLAL-LAPGPWLALIGLALVG---LGLSLMfptIFSLALDGLGKRTAAA-VSAVLIMGIVGGAIGPPLI 354
|
330 340 350
....*....|....*....|....*....|
gi 548511 407 GWINTVTGSLAIGLTIIGALVLAGGMAVLI 436
Cdd:COG0738 355 GFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
190-435 |
8.84e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.37 E-value: 8.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 190 NWQWMFILEGLPAAVMGVMAYFYLVDKPeqakwlddeeksiildalAADRAGKKPVTdKRHAVLAALKDPRVYVLAagWA 269
Cdd:cd17475 148 GWRAAFVVAGLVSILAAVLFWLFYREPP------------------AASAATESAST-LLRSLKEVLRNRDVWLIA--IA 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 270 TVPLCG---TILNYWTPTIIRNTGIqDVLHVGLLSTVPYIVGAIAMILIARSSD-IRLERRKHFFFSIAFGALGACLLPH 345
Cdd:cd17475 207 GALLVApqfALLTFLLLFLHDHLGL-SVVAAGALLAVAQLGGALGRIGLGRVSDrVFGGRRRPVLVITAAIAAAALLVLS 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 346 VVDSAIISItcLAMIAVSYFGAAAIIWSIPPAYLNDESA----AGGISAIS-SLGQIGAFCAPIGLGWINTVTGSLAIGL 420
Cdd:cd17475 286 LLSPGTPLW--LLVLLLILLGLFAIGWNGLYLTLVAESAgpeqAGTALGLAnTINFIGIAIGPPLFGLLVDATHSYAPAW 363
|
250
....*....|....*
gi 548511 421 TIIGALVLAGGMAVL 435
Cdd:cd17475 364 LALALLLVLAALLLL 378
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
104-207 |
9.71e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 37.92 E-value: 9.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 104 VLWGLISASMAFMTTPTEFYIARALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFv 183
Cdd:cd17321 69 ALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF- 147
|
90 100
....*....|....*....|....
gi 548511 184 dvmgmkNWQWMFILeGLPAAVMGV 207
Cdd:cd17321 148 ------GWRWIFLI-NVPIGLVAL 164
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
36-227 |
9.91e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 38.10 E-value: 9.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 36 IFVAWVLNYLDRVNISFAQVYLKHDLGMSDADLRTRrKLVFHRLHRIGNTQYAYL-------QKIGARLTITRIMVLwgL 108
Cdd:PRK09556 34 VFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMI-GLGFSITYGVGKTLVGYYadgkntkQFLPFLLILSAICML--G 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548511 109 ISASMAFMTTPTEFYIA-RALLGAAEAGFWPGIILYLTYWYPGARRARITSRFLLAIAAAGIIGGPLSGWILTHFVD--V 185
Cdd:PRK09556 111 FGASLGSGSVSLGLMIAlWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDghV 190
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 548511 186 MGMknwqwmFILEGLPAAVMGVMAYFYLVDKPEQAKWLDDEE 227
Cdd:PRK09556 191 IGM------FIFPSIIALIIGFIGLRYGSDSPEELGWGKAEE 226
|
|
| |
