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Conserved domains on  [gi|54695646|gb|AAV38195|]
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purine-rich element binding protein A [Homo sapiens]

Protein Classification

Pur family transcription activator( domain architecture ID 12058637)

Pur family transcription activator such as Pur-alpha (PurA), Pur-beta (PurB), and Pur-gamma (PurG), which bind preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 58-278 1.56e-127

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


:

Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 363.00  E-value: 1.56e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54695646    58 TQELASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGDKSRLTLSMSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQaqd 137
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGGRKSRITLSMSVAAEFKDELSKFSDHYAQLGPSNGEHLPE--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54695646   138 EPRRALKSEFLVRENRKYYMDLKENQRGRFLRIRQTVNRGPGLGstQGQTIALPAQGLIEFRDALAKLIDDYGV---EEE 214
Cdd:pfam04845  78 DGSSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMRGNPRG--QRQQIALPAQGMIEFRDALTDLIEDYGEgdeNDI 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 54695646   215 PAELPEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKYSEEM 278
Cdd:pfam04845 156 PQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNYRNSITVPEKAWTRFRDIFDKYIEKM 219
 
Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 58-278 1.56e-127

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 363.00  E-value: 1.56e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54695646    58 TQELASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGDKSRLTLSMSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQaqd 137
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGGRKSRITLSMSVAAEFKDELSKFSDHYAQLGPSNGEHLPE--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54695646   138 EPRRALKSEFLVRENRKYYMDLKENQRGRFLRIRQTVNRGPGLGstQGQTIALPAQGLIEFRDALAKLIDDYGV---EEE 214
Cdd:pfam04845  78 DGSSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMRGNPRG--QRQQIALPAQGMIEFRDALTDLIEDYGEgdeNDI 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 54695646   215 PAELPEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKYSEEM 278
Cdd:pfam04845 156 PQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNYRNSITVPEKAWTRFRDIFDKYIEKM 219
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 60-122 2.05e-24

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 93.83  E-value: 2.05e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 54695646     60 ELASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGDKSRLTLSMSVAVEFRDYLGDFIEHYA 122
Cdd:smart00712   1 ELASKKLTVENKRFYFDVKENRRGRFLRISEVKNNGGRSSITVPEQGAAEFRDALTKLIEKYG 63
 
Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 58-278 1.56e-127

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 363.00  E-value: 1.56e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54695646    58 TQELASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGDKSRLTLSMSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQaqd 137
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGGRKSRITLSMSVAAEFKDELSKFSDHYAQLGPSNGEHLPE--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54695646   138 EPRRALKSEFLVRENRKYYMDLKENQRGRFLRIRQTVNRGPGLGstQGQTIALPAQGLIEFRDALAKLIDDYGV---EEE 214
Cdd:pfam04845  78 DGSSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMRGNPRG--QRQQIALPAQGMIEFRDALTDLIEDYGEgdeNDI 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 54695646   215 PAELPEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKYSEEM 278
Cdd:pfam04845 156 PQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNYRNSITVPEKAWTRFRDIFDKYIEKM 219
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 60-122 2.05e-24

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 93.83  E-value: 2.05e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 54695646     60 ELASKRVDIQNKRFYLDVKQNAKGRFLKIAEVGAGGDKSRLTLSMSVAVEFRDYLGDFIEHYA 122
Cdd:smart00712   1 ELASKKLTVENKRFYFDVKENRRGRFLRISEVKNNGGRSSITVPEQGAAEFRDALTKLIEKYG 63
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 218-279 1.11e-22

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 89.20  E-value: 1.11e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 54695646    218 LPEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTY-RNSITVPYKVWAKFGHTFCKYSEEMK 279
Cdd:smart00712   1 ELASKKLTVENKRFYFDVKENRRGRFLRISEVKNNGgRSSITVPEQGAAEFRDALTKLIEKYG 63
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 143-210 7.37e-22

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 86.89  E-value: 7.37e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 54695646    143 LKSEFLVRENRKYYMDLKENQRGRFLRIRQTVNRGpglgstQGQTIALPAQGLIEFRDALAKLIDDYG 210
Cdd:smart00712   2 LASKKLTVENKRFYFDVKENRRGRFLRISEVKNNG------GRSSITVPEQGAAEFRDALTKLIEKYG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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