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Conserved domains on  [gi|545478627|ref|NP_001269896|]
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ETS domain-containing protein Elk-3 isoform Elk3d [Mus musculus]

Protein Classification

ETS domain-containing protein( domain architecture ID 10648030)

ETS (erythroblast transformation specific) domain-containing protein may function as a transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 5-69 2.07e-33

erythroblast transformation specific domain; variation of the helix-turn-helix motif


:

Pssm-ID: 197710  Cd Length: 87  Bit Score: 112.36  E-value: 2.07e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545478627     5 ITLWQFLLHLLLDQKHEHLICWTSND-GEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDK 69
Cdd:smart00413   2 IQLWQFLLDLLLDPENSDIIKWTDRDeGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKK 67
 
Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 5-69 2.07e-33

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 112.36  E-value: 2.07e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545478627     5 ITLWQFLLHLLLDQKHEHLICWTSND-GEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDK 69
Cdd:smart00413   2 IQLWQFLLDLLLDPENSDIIKWTDRDeGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKK 67
Ets pfam00178
Ets-domain;
6-69 1.67e-29

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 102.19  E-value: 1.67e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545478627    6 TLWQFLLHLLLDQKHEHLICWTSND-GEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDK 69
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKEeGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKK 65
HKU9-like_Nsp3_betaSM cd21813
betacoronavirus-specific marker of non-structural protein 3 from Rousettus bat coronavirus ...
 33-79 7.60e-03

betacoronavirus-specific marker of non-structural protein 3 from Rousettus bat coronavirus HKU9 and betacoronavirus in the D lineage; This model represents the betacoronavirus-specific marker (betaSM), also called group 2-specific marker (G2M), of non-structural protein 3 (Nsp3) from betacoronavirus in the nobecovirus subgenus (D lineage), including Rousettus bat coronavirus HKU9. The betaSM/G2M is located C-terminal to the nucleic acid-binding (NAB) domain. This region is absent in alpha- and deltacoronavirus Nsp3; there is a gammacoronavirus-specific marker (gammaSM) at this position in gammacoronavirus Nsp3. Nsp3 is a large multi-functional multi-domain protein that is an essential component of the replication/transcription complex (RTC), which carries out RNA synthesis, RNA processing, and interference with the host cell innate immune system. Little is known about the betaSM/G2M domain; it is predicted to be non-enzymatic and may be an intrinsically disordered region. The betaSM/G2M domain is part of the predicted PLnc domain (made up of 385 amino acids) of the related SARS-CoV Nsp3 that may function as a replication/transcription scaffold, with interactions to Nsp5, Nsp12, Nsp13, Nsp14, and Nsp16.


Pssm-ID: 409628  Cd Length: 135  Bit Score: 34.32  E-value: 7.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 545478627  33 FKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDKTPSGLFLASS 79
Cdd:cd21813   64 FVLLKASHLSKLLGLRVSDTTLRVNKLSKSLVYAYAATKFTTRVTKS 110
 
Name Accession Description Interval E-value
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 5-69 2.07e-33

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 112.36  E-value: 2.07e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545478627     5 ITLWQFLLHLLLDQKHEHLICWTSND-GEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDK 69
Cdd:smart00413   2 IQLWQFLLDLLLDPENSDIIKWTDRDeGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKK 67
Ets pfam00178
Ets-domain;
6-69 1.67e-29

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 102.19  E-value: 1.67e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545478627    6 TLWQFLLHLLLDQKHEHLICWTSND-GEFKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDK 69
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKEeGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKK 65
HKU9-like_Nsp3_betaSM cd21813
betacoronavirus-specific marker of non-structural protein 3 from Rousettus bat coronavirus ...
 33-79 7.60e-03

betacoronavirus-specific marker of non-structural protein 3 from Rousettus bat coronavirus HKU9 and betacoronavirus in the D lineage; This model represents the betacoronavirus-specific marker (betaSM), also called group 2-specific marker (G2M), of non-structural protein 3 (Nsp3) from betacoronavirus in the nobecovirus subgenus (D lineage), including Rousettus bat coronavirus HKU9. The betaSM/G2M is located C-terminal to the nucleic acid-binding (NAB) domain. This region is absent in alpha- and deltacoronavirus Nsp3; there is a gammacoronavirus-specific marker (gammaSM) at this position in gammacoronavirus Nsp3. Nsp3 is a large multi-functional multi-domain protein that is an essential component of the replication/transcription complex (RTC), which carries out RNA synthesis, RNA processing, and interference with the host cell innate immune system. Little is known about the betaSM/G2M domain; it is predicted to be non-enzymatic and may be an intrinsically disordered region. The betaSM/G2M domain is part of the predicted PLnc domain (made up of 385 amino acids) of the related SARS-CoV Nsp3 that may function as a replication/transcription scaffold, with interactions to Nsp5, Nsp12, Nsp13, Nsp14, and Nsp16.


Pssm-ID: 409628  Cd Length: 135  Bit Score: 34.32  E-value: 7.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 545478627  33 FKLLKAEEVAKLWGLRKNKTNMNYDKLSRALRYYYDKTPSGLFLASS 79
Cdd:cd21813   64 FVLLKASHLSKLLGLRVSDTTLRVNKLSKSLVYAYAATKFTTRVTKS 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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