|
Name |
Accession |
Description |
Interval |
E-value |
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
1-338 |
3.00e-104 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 314.57 E-value: 3.00e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDvfAEIP 79
Cdd:pfam01131 101 EKLKKGT-AVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDD--ATLK 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 80 ALIAFL-HDHPVWGVHARRLTELNA--HSVDGKKVTDHHALLITGKKPIDIF--GEEVVIYDMIAGRMLEAFSARCVKDV 154
Cdd:pfam01131 178 AILEYLtKNYGKYLPYAPRLLKKTKgkLTVGNAKVTAHEAIRPTGDIPVLPElsDDERKLYELIVRRFLASQMPPAVYET 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 155 STVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKP 234
Cdd:pfam01131 258 TTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEE----------------ELPELKEGEELKVTQVEVEEKKTKPPP 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 235 LHTESSLLAAMETagkeledeelraqlkdCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM-KIGNA 313
Cdd:pfam01131 322 RYTEASLIKAMEK----------------AGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEALEKFpDLVDP 385
|
330 340
....*....|....*....|....*
gi 545423095 314 EMTGQWEADLAKIERGELKERDFRK 338
Cdd:pfam01131 386 ELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
9-390 |
3.41e-95 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 299.00 E-value: 3.41e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 9 ATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKA-YITYPRTGSRHIPEDVFAEIPALI-AFLH 86
Cdd:PRK07726 263 AKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYETHkLITYPRTDSRYLPEDMVATLPEVLnAISK 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 87 DHPVWGVHARRL-TELNAHSVDGKKVTDHHALLITGKKPiDIF---GEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCE 162
Cdd:PRK07726 343 VDPYLLLAPPVLdPSIRSRAWNDKKVTAHHAIIPTEQPP-NLSklsEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIA 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 163 GVKFILKGEIIKEEGWRTILKNSRKKDKEQAeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLL 242
Cdd:PRK07726 422 GGTFIAKGKQVVEAGWKALLGKKEEDEEKEQ--------------PLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLL 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 243 AAMETAGKELEDEELRAQLKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVkGMKIGNAEMTGQWEA 321
Cdd:PRK07726 488 SAMENIARFVQDKELKKTLKETdGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLIDAL-PEELTSPDMTAKWEQ 566
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545423095 322 DLAKIERGELKERDFRKGIESYATQITDELLSSKILF----PKKQSdihCPKCGKGSLVFYPR---CAKCSDADCG 390
Cdd:PRK07726 567 ALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYkfdnLTGPK---CPDCGKPMLKVKGKngkMLVCQDRECG 639
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-349 |
1.40e-91 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 286.22 E-value: 1.40e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPA 80
Cdd:COG0550 224 AALKGKT-FTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSEDAVAAARE 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 81 LIA------FLHDHPvwgvharrltelNAHSVDGKKVTDHHALLITG--KKPIDIFGEEVVIYDMIAGRMLEAFSARCVK 152
Cdd:COG0550 303 YIEalygkeYLPEKP------------RVYKTSKNAQEAHEAIRPTGvtRTPESLSGDEFKLYDLIWKRFLASQMPPAEY 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 153 DVSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAekresrengegiIIPQWEEGKQLPLCACSLTQGTTKP 232
Cdd:COG0550 371 ETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEEEEK------------RLPPLKEGEKLKLKKIEPEQHFTKP 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 233 KPLHTESSLLAAMETAgkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KI 310
Cdd:COG0550 439 PPRYTEASLVKAMEEL----------------GIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHfpDL 502
|
330 340 350
....*....|....*....|....*....|....*....
gi 545423095 311 GNAEMTGQWEADLAKIERGELKERDFRKGIESYATQITD 349
Cdd:COG0550 503 VDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
7-336 |
1.14e-80 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 253.30 E-value: 1.14e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 7 SVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEipALIAFLH 86
Cdd:cd00186 67 KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILE--AREYIQA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 87 DHPVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKPIDIF-----GEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVC 161
Cdd:cd00186 145 IYGKEYLYPAPLLGRRNPKRGKKEQGAHEAIRPTKVAPTPELeanlsEDEFKLYELIWRRFLASQMADAKYEETTVTLEI 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 162 EGVKFILKGEIIKEEGWRTILKNSRKKDKEQAeaekresrengegiiiPQWEEGKQLPLCACSLTQGTTKPKPLHTESSL 241
Cdd:cd00186 225 GGEKFKASGKVLLEDGWLEVYPEEKDDEEEEP----------------PPLKEGDELKLEEVELEEKETQPPPRYTEASL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 242 LAAMETAgkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KIGNAEMTGQW 319
Cdd:cd00186 289 IKLMEKR----------------GIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHfpELVDPEFTAKL 352
|
330
....*....|....*..
gi 545423095 320 EADLAKIERGELKERDF 336
Cdd:cd00186 353 EEKLDEIAEGKKDYQEV 369
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
9-382 |
5.80e-75 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 246.29 E-value: 5.80e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 9 ATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDVFAEIPALIAFLHD 87
Cdd:TIGR01056 266 ALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYEThKLITYPRTDSRYLPEDEKEMLLEVLDALKV 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 88 H-PVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKP--IDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGV 164
Cdd:TIGR01056 346 ItPALLPIKKRDELTNNRLWNDKKIEDHHAIIPTGNDFnlSDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKL 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 165 KFILKGEIIKEEGWRTILkNSRKKDKEQaeaekresrengEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAA 244
Cdd:TIGR01056 426 MFEAKGKILQDNGWKALL-GKQEEDEET------------EDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSA 492
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 245 METAGKELEDEELRAQLKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGMkIGNAEMTGQWEADL 323
Cdd:TIGR01056 493 MTNPAAFVQDKGLKKTLKETkGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLLCLLLPEL-LTKPDLTAQWEQYL 571
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 545423095 324 AKIERGELKERDFRKGIESYATQITDELLSSKILFPKKQSdihcPKCGKGSLVFYPRCA 382
Cdd:TIGR01056 572 NGISAGEKDDDDFINTINEMIKQTINEEKKNPETIQKVAK----EPVSCGGIAKCPAKD 626
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
16-301 |
4.53e-68 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 216.34 E-value: 4.53e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 16 RKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPALIAFlHDHPVWGVHA 95
Cdd:smart00437 2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQK-LYGKEYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 96 RRLTELNAHSVDGKKVTDHHALLITGKKP-----IDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGVKFILKG 170
Cdd:smart00437 81 VVLLKPRKPRKGKKAQGAHEAIRPTKPIFtpeleKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 171 EIIKEEGWRTILKNSRKkdkeqaeaekresrenGEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAAMETAgk 250
Cdd:smart00437 161 KTLLFDGWLKVYPEEKK----------------EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKR-- 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 545423095 251 eledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAV 301
Cdd:smart00437 223 --------------GIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
388-416 |
1.54e-03 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 36.69 E-value: 1.54e-03
10 20
....*....|....*....|....*....
gi 545423095 388 DCGLTLFRSVAGKSLTDEQLTQLAVNGET 416
Cdd:pfam13342 1 GCGFSIGKTIAGKKLSEEQVKELLTKGKT 29
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
1-338 |
3.00e-104 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 314.57 E-value: 3.00e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDvfAEIP 79
Cdd:pfam01131 101 EKLKKGT-AVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDD--ATLK 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 80 ALIAFL-HDHPVWGVHARRLTELNA--HSVDGKKVTDHHALLITGKKPIDIF--GEEVVIYDMIAGRMLEAFSARCVKDV 154
Cdd:pfam01131 178 AILEYLtKNYGKYLPYAPRLLKKTKgkLTVGNAKVTAHEAIRPTGDIPVLPElsDDERKLYELIVRRFLASQMPPAVYET 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 155 STVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKP 234
Cdd:pfam01131 258 TTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEE----------------ELPELKEGEELKVTQVEVEEKKTKPPP 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 235 LHTESSLLAAMETagkeledeelraqlkdCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM-KIGNA 313
Cdd:pfam01131 322 RYTEASLIKAMEK----------------AGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEALEKFpDLVDP 385
|
330 340
....*....|....*....|....*
gi 545423095 314 EMTGQWEADLAKIERGELKERDFRK 338
Cdd:pfam01131 386 ELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
9-390 |
3.41e-95 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 299.00 E-value: 3.41e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 9 ATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKA-YITYPRTGSRHIPEDVFAEIPALI-AFLH 86
Cdd:PRK07726 263 AKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYETHkLITYPRTDSRYLPEDMVATLPEVLnAISK 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 87 DHPVWGVHARRL-TELNAHSVDGKKVTDHHALLITGKKPiDIF---GEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCE 162
Cdd:PRK07726 343 VDPYLLLAPPVLdPSIRSRAWNDKKVTAHHAIIPTEQPP-NLSklsEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIA 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 163 GVKFILKGEIIKEEGWRTILKNSRKKDKEQAeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLL 242
Cdd:PRK07726 422 GGTFIAKGKQVVEAGWKALLGKKEEDEEKEQ--------------PLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLL 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 243 AAMETAGKELEDEELRAQLKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVkGMKIGNAEMTGQWEA 321
Cdd:PRK07726 488 SAMENIARFVQDKELKKTLKETdGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLIDAL-PEELTSPDMTAKWEQ 566
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545423095 322 DLAKIERGELKERDFRKGIESYATQITDELLSSKILF----PKKQSdihCPKCGKGSLVFYPR---CAKCSDADCG 390
Cdd:PRK07726 567 ALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYkfdnLTGPK---CPDCGKPMLKVKGKngkMLVCQDRECG 639
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-349 |
1.40e-91 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 286.22 E-value: 1.40e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPA 80
Cdd:COG0550 224 AALKGKT-FTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSEDAVAAARE 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 81 LIA------FLHDHPvwgvharrltelNAHSVDGKKVTDHHALLITG--KKPIDIFGEEVVIYDMIAGRMLEAFSARCVK 152
Cdd:COG0550 303 YIEalygkeYLPEKP------------RVYKTSKNAQEAHEAIRPTGvtRTPESLSGDEFKLYDLIWKRFLASQMPPAEY 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 153 DVSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAekresrengegiIIPQWEEGKQLPLCACSLTQGTTKP 232
Cdd:COG0550 371 ETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEEEEK------------RLPPLKEGEKLKLKKIEPEQHFTKP 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 233 KPLHTESSLLAAMETAgkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KI 310
Cdd:COG0550 439 PPRYTEASLVKAMEEL----------------GIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHfpDL 502
|
330 340 350
....*....|....*....|....*....|....*....
gi 545423095 311 GNAEMTGQWEADLAKIERGELKERDFRKGIESYATQITD 349
Cdd:COG0550 503 VDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
7-336 |
1.14e-80 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 253.30 E-value: 1.14e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 7 SVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEipALIAFLH 86
Cdd:cd00186 67 KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILE--AREYIQA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 87 DHPVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKPIDIF-----GEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVC 161
Cdd:cd00186 145 IYGKEYLYPAPLLGRRNPKRGKKEQGAHEAIRPTKVAPTPELeanlsEDEFKLYELIWRRFLASQMADAKYEETTVTLEI 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 162 EGVKFILKGEIIKEEGWRTILKNSRKKDKEQAeaekresrengegiiiPQWEEGKQLPLCACSLTQGTTKPKPLHTESSL 241
Cdd:cd00186 225 GGEKFKASGKVLLEDGWLEVYPEEKDDEEEEP----------------PPLKEGDELKLEEVELEEKETQPPPRYTEASL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 242 LAAMETAgkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KIGNAEMTGQW 319
Cdd:cd00186 289 IKLMEKR----------------GIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHfpELVDPEFTAKL 352
|
330
....*....|....*..
gi 545423095 320 EADLAKIERGELKERDF 336
Cdd:cd00186 353 EEKLDEIAEGKKDYQEV 369
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
17-415 |
1.92e-77 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 256.52 E-value: 1.92e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 17 KETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDVFAEIPALIAFLHDHPVWGVHA 95
Cdd:PRK08173 281 KPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKQTLEMLKESNNYLPHA 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 96 RRLTE-----LNAHSVDGKKVTDHHALLITGKKPIDIFGEEVVIYDMIAGRMLEAFSARCVKDVST-VTAVcEGVKFILK 169
Cdd:PRK08173 361 KQILDkgwvkPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTrITEV-AGHHFKTE 439
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 170 GEIIKEEGWRTILKnsrkkdkeqaeaeKRESRENGEGIIIPQWEEGKQLPLCACSLTqgtTKPKPLHTESSLLAAMETAG 249
Cdd:PRK08173 440 GKVLVNPGWLAVYG-------------KEAQGADANLVPVQKGEKVKTDKIEAVALT---TKPPARYNEATLLSAMEGAG 503
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 250 KELEDEELRAQLKDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGMKIG---NAEMTGQWEADLAKI 326
Cdd:PRK08173 504 KLVEDDELREAMAEKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVEeltSPELTGEWEYKLSQI 583
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 327 ERGELKERDFRKGIESYATQITD---ELLSSKILFPKKQSDIHCPKCGKGSLVFYPRCAkCSdaDCGLTLFRSVAGKSLT 403
Cdd:PRK08173 584 ERGKLSRDAFMQEIAQMTQQIVKrakEYDSDTIPGDYATLQTPCPNCGGVVKENYRRFA-CT--KCDFSISKIPGGRQFE 660
|
410
....*....|..
gi 545423095 404 DEQLTQLAVNGE 415
Cdd:PRK08173 661 IAEVEELLRKKE 672
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
9-382 |
5.80e-75 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 246.29 E-value: 5.80e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 9 ATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDVFAEIPALIAFLHD 87
Cdd:TIGR01056 266 ALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYEThKLITYPRTDSRYLPEDEKEMLLEVLDALKV 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 88 H-PVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKP--IDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGV 164
Cdd:TIGR01056 346 ItPALLPIKKRDELTNNRLWNDKKIEDHHAIIPTGNDFnlSDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKL 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 165 KFILKGEIIKEEGWRTILkNSRKKDKEQaeaekresrengEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAA 244
Cdd:TIGR01056 426 MFEAKGKILQDNGWKALL-GKQEEDEET------------EDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSA 492
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 245 METAGKELEDEELRAQLKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGMkIGNAEMTGQWEADL 323
Cdd:TIGR01056 493 MTNPAAFVQDKGLKKTLKETkGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLLCLLLPEL-LTKPDLTAQWEQYL 571
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 545423095 324 AKIERGELKERDFRKGIESYATQITDELLSSKILFPKKQSdihcPKCGKGSLVFYPRCA 382
Cdd:TIGR01056 572 NGISAGEKDDDDFINTINEMIKQTINEEKKNPETIQKVAK----EPVSCGGIAKCPAKD 626
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
16-301 |
4.53e-68 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 216.34 E-value: 4.53e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 16 RKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPALIAFlHDHPVWGVHA 95
Cdd:smart00437 2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQK-LYGKEYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 96 RRLTELNAHSVDGKKVTDHHALLITGKKP-----IDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGVKFILKG 170
Cdd:smart00437 81 VVLLKPRKPRKGKKAQGAHEAIRPTKPIFtpeleKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 171 EIIKEEGWRTILKNSRKkdkeqaeaekresrenGEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAAMETAgk 250
Cdd:smart00437 161 KTLLFDGWLKVYPEEKK----------------EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKR-- 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 545423095 251 eledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAV 301
Cdd:smart00437 223 --------------GIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
17-410 |
7.04e-65 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 224.06 E-value: 7.04e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 17 KETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDVFAEIPALIAFLHDHPVWGVHA 95
Cdd:PRK14724 289 KPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDYLPVAKQTFEMLATSGMRHLAP 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 96 RRLTELNAHSV-------DGKKVTDHHALLITGKKPIDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGVKFIL 168
Cdd:PRK14724 369 FAQQALDGNYVrpskrifDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKT 448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 169 KGEIIKEEGWRTILKnsrkkdkEQAEAEKRESRENGEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAAMETA 248
Cdd:PRK14724 449 EGKVLVKPGWLAIYG-------KEAANEVEDAKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMESA 521
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 249 GKELEDEELRAQLKDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM---KIGNAEMTGQWEADLAK 325
Cdd:PRK14724 522 GKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLgveELSRAELTGEWEYKLAQ 601
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 326 IERGELKERDFRKGIESYATQITDELLS-SKILFPKKQSDIH--CPKCGKGSLVFYPRCAkCSDAD-----CGLTLFRSV 397
Cdd:PRK14724 602 MEKGQLSREAFMQQIAAMTEKLVKKAKEyDRDTIPGDYATLStpCPNCGGVVKENYRRYA-CTGANgagegCGFSFTKSP 680
|
410
....*....|...
gi 545423095 398 AGKSLTDEQLTQL 410
Cdd:PRK14724 681 AGRTFETAEAEQL 693
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
1-372 |
1.53e-49 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 179.43 E-value: 1.53e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVfaEIPA 80
Cdd:PRK07219 258 EKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDL--DPKE 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 81 LIAFLHDHPVWGVHARR-LTELNAHSVDGKK-VTDHHALLITGKKPI-DIFGEEVVIYDMIAGRMLEAFSARCVKDVSTV 157
Cdd:PRK07219 336 LLKKLSKKKEYGPYAESiLEQENIKPTEGKKeTTDHPPIHPVDVPKReELSDDEWKVYELIVRRFLATLADPAEWEYLKV 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 158 TAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiiIPQWEEGKQLPLCACSLTQGTTKPKPLHT 237
Cdd:PRK07219 416 ELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKE-----------------LPDLEEGEKLKVNKIEIEAKETQPPKRYT 478
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 238 ESSLLAAMEtagkeledeelraqlkDCGIGTPATRAAIIETLFAREYMVRQkKSLVPTEKGLAVYSIVKGM--KIGNAEM 315
Cdd:PRK07219 479 QSSLIKEME----------------KRGLGTKATRHDIIEKLYKRGYVIEG-DPPRPTDLGIAVIEALEKYapEIVSEEM 541
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545423095 316 TGQWEADLAKIERGE-------------LKE-----RDFRKGIESY-ATQITDELLSSKILFPkkqsdihCPKCGK 372
Cdd:PRK07219 542 TAQLEADMQAIEDGKkkkedvteesremLKEilselKEKRKEIGDHlAGSLKAENRSLKTIGK-------CPECGG 610
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
1-371 |
1.10e-48 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 175.57 E-value: 1.10e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVfaEIPA 80
Cdd:PRK05776 252 EEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKTQSIAEDLYLDGLISYPRTNSQKLPPTL--NIRN 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 81 LIAFLHDHPVWG--VHA-RRLTELNAHSVDGKKvTD--HHALLITGKKPIDIFGEEVVIYDMIAGRMLEAFSARCVKDVS 155
Cdd:PRK05776 330 ILKGLSRSPQYRplVNLlLKETKGVLKPVQGPK-DDpaHPAIYPTGEPPKNLSKDEFKLYDLIVRRFLASFAAPAVLSNT 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 156 TVTAVCEGV--KFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiiIPQWEEGKQLPLCACSLTQGTTKPK 233
Cdd:PRK05776 409 IVTLRVPGFplVFSASGQRIEERGWLKYYPFHKFDEEE-----------------LPLLKKGERVKIVDVKVRKSYTKPP 471
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 234 PLHTESSLLAAMEtagkeledeelraqlkDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KIG 311
Cdd:PRK05776 472 SRYSKASLLKWME----------------SVGIGTEATRARIIETLFKRGYLTSNGKYIEVTPLGFGVAEVLEKYfpDIV 535
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545423095 312 NAEMTGQWEADLAKIERGELKERD--------FRKGIESYAT---QITDELLSS-KILFPKKQsdihCPKCG 371
Cdd:PRK05776 536 SVELTRDFEEKLEMIRTGKATREEvieeaketLNKLLEEFKKnkdEIGEELAKAlGLIKPVGK----CKICG 603
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-376 |
7.82e-40 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 150.78 E-value: 7.82e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYE--------KAYITYPRTGSRHIPE 72
Cdd:PRK06599 236 KALEGQA-YTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEgidlgegtVGLITYMRTDSVRLSN 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 73 DVFAEIPALI------AFLHDHPvwgvharrltelNAHSVDGKKVTD-HHALlitgkKPIDIF-----------GEEVVI 134
Cdd:PRK06599 315 EALDEARKYItkkygkEYLPAKP------------RVYKKKSKNAQEaHEAI-----RPTSINrtpeslkpyltPDQFKL 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 135 YDMI-----AGRMLEAfsarcVKDVSTVTAVCEGVKFILK--GEIIKEEGWRTILKNSRKKDKEQAEAekresrengegi 207
Cdd:PRK06599 378 YELIwkrtvASQMAPA-----ILDQTSVDIASENGKYVFRatGSVILFPGFLKVYGESKDDEEEDDEK------------ 440
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 208 IIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLaametagKELEDEelraqlkdcGIGTPATRAAIIETLFAREYMVR 287
Cdd:PRK06599 441 LLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLV-------KKLEEY---------GIGRPSTYASIISTLQDREYVEL 504
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 288 QKKSLVPTEKGLavysIVKGM------KIGNAEMTGQWEADLAKIERGE------LKE--RDFRKGIESYATQITDELLs 353
Cdd:PRK06599 505 EKKRFIPTDLGR----IVNDFlvehfpKYVDYDFTAGLEDELDEIAEGKkdwkpvLREfwEPFISNLEKVEEDVRTEKV- 579
|
410 420
....*....|....*....|...
gi 545423095 354 skilfPKKQSDIHCPKCGKGSLV 376
Cdd:PRK06599 580 -----TQEETDETCPKCGGGPLV 597
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
1-373 |
8.67e-30 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 121.82 E-value: 8.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNA--SVATVEtivRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEI 78
Cdd:PRK07561 246 AALEGArySVASVE---DKPTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYITYMRTDSTNLSQEAINAA 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 79 PALIA------FLHDHP-VWGVHAR---------RLTELNAHSVDGKKVTdhhallitgkkpidifGEEVVIYDMI---- 138
Cdd:PRK07561 323 RGYIGdnygkkYLPEKPrQYSSKAKnaqeaheaiRPSDVFRTPDQLKGLE----------------GDAQRLYELIwkrf 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 139 -AGRMLEAfsarcVKDVSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAekresrengegiIIPQWEEGKQ 217
Cdd:PRK07561 387 vASQMAPA-----RYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRDDALDDEDR------------RLPALKVGDA 449
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 218 LPLCACSLTQGTTKPKPLHTESSLLaametagKELEDEelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEK 297
Cdd:PRK07561 450 LTLEKLDPTQHFTKPPARYSEASLV-------KELEKL---------GIGRPSTYASIISTIQDRGYVRLENRRFYPEKM 513
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 298 GLAV-------------YSIVKGMkignaemtgqwEADLAKIERGE------LKE--RDFRKGIESyatqiTDELLSSKI 356
Cdd:PRK07561 514 GRIVtdrleeffprlvdYDFTARM-----------EEELDDIANGEadwkpvLDDfyKDFSQQLEK-----AEELREEGG 577
|
410
....*....|....*....
gi 545423095 357 LFP--KKQSDIHCPKCGKG 373
Cdd:PRK07561 578 MRPnqMVITDRDCPTCGRG 596
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-376 |
6.60e-27 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 113.38 E-value: 6.60e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASVaTVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYE---------KAYITYPRTGSRHIP 71
Cdd:PRK06319 246 ELLESATY-TVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYEgvdldsegaTGLITYMRTDSVRTD 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 72 EDVFAEIPALIA------FLHDHPvwGVHARRLTELNAHsvDGKKVTDHHalLITGKKPIDIFGEEVVIYDMIAGRMLEA 145
Cdd:PRK06319 325 PEALKQVRKYIEgtfgkeFLPSSP--NVYTTKKMAQDAH--EAIRPTDIT--LTPEKLRSKLTEDQYKLYSLIWKRFVAS 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 146 FSARCVKDVSTVTaVCEGVKFILK--GEIIKEEGWRTILKnsRKKDKEQAEAEkresrengeGIIIPQWEEGKQLPLCAC 223
Cdd:PRK06319 399 QMIPAIYDTLAIR-ITTNKGIDLRatGSLLKFKGFLAVYE--EKRDDEGDEEE---------NIHLPKLHEQDVLTKEEL 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 224 SLTQGTTKPKPLHTESSLLaametagKELEDEelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYS 303
Cdd:PRK06319 467 SAEQAFTKPLPRFTEASLV-------KELEKS---------GIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIISQ 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 304 IV-----KGMKIGnaeMTGQWEADLAKIERgelKERDFRKGIESYATQI--TDELLSSKILFPKKQSDIHCPKCGKGSLV 376
Cdd:PRK06319 531 FLetnfpRIMDIG---FTALMEDELELIAD---NKKPWKLLLQEFWELFlpVVVTAEKEAFIPRIVTEIDCPKCHKGKLV 604
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
7-372 |
6.09e-26 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 110.23 E-value: 6.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 7 SVATVETIVRKETRQEPPLLYDLTTLQKEANSrFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVfaEIPALIAFLH 86
Cdd:PRK07220 258 KTAEVTEVEKGTKTDKPPTPFNTTEFISAANS-IGFSAANAMRIAESLYTNGYISYPRTDNTVYPESL--DLREQIEIFA 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 87 DHPVwGVHARRLteLNAHSV---DGKK-VTDHHALLITGK-KPIDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVC 161
Cdd:PRK07220 335 EGPF-GEYAQKL--LEKGELvptRGKKeTTDHPPIYPASLaKKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDI 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 162 EGVKFILKGEIIKEEGWRTILKNSRKKDKeqaeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSL 241
Cdd:PRK07220 412 GGEEFRANGSRLTEPGWRWYYPYNAPEDR-----------------LLPELSEGEELKVKKKEMLDKETQPPGRYGQGRL 474
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 242 LAAMEtagkeledeelraqlkDCGIGTPATRAAIIETLFAREYMvrQKKSLVPTEKGLAVysiVKGMK-----IGNAEMT 316
Cdd:PRK07220 475 IKLME----------------DLGLGTKATRHEIISKLYSRAYI--HGNPIQPTNTAFAV---VDALEkyaptITKPDMT 533
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545423095 317 GQWEADLAKIERGELKERDFRKGIESYATQITDELLSSK-----ILFPKKQSDI---HCPKCGK 372
Cdd:PRK07220 534 SRLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDKNRekireSLREGLREDKiigKCPLCGS 597
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
8-330 |
4.97e-25 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 107.54 E-value: 4.97e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 8 VATVEtivRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK---------AYITYPRTGSRHIPEDVFAEI 78
Cdd:PRK08780 248 VTDVE---SKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQKLYEGvdlgdegsvGLITYMRTDSVNLSQDALAEI 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 79 PALIA------FLHDHPvwgvharrltelNAHSVDGKKVTD-HHALLITG--KKPIDIFG----EEVVIYDMI-----AG 140
Cdd:PRK08780 325 RDVIArdygtaSLPDQP------------NTYKTKSKNAQEaHEAVRPTSalRTPAQVARflsdDQRRLYELIwkravAC 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 141 RMLEAfsarCVKDVSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAEKResrengegiIIPQWEEGKQLPL 220
Cdd:PRK08780 393 QMIPA----TLNTVSVDLAAGSEHVFRATGSTVVVPGFLAVYEEGKDDKSAEDEDEGR---------KLPPMKEGDNVPL 459
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 221 CACSLTQGTTKPKPLHTESSLLAAMEtagkeledeelraqlkDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLA 300
Cdd:PRK08780 460 ERIRAEQHFTEPPPRYTEASLVKALE----------------EYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRA 523
|
330 340 350
....*....|....*....|....*....|..
gi 545423095 301 VYSIVKGM--KIGNAEMTGQWEADLAKIERGE 330
Cdd:PRK08780 524 VNKFLTGHftRYVDYDFTARLEDDLDAVSRGE 555
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
6-381 |
5.34e-18 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 86.44 E-value: 5.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 6 ASVATVETIVRKETRQ-----EPPLLYDLTTLQKEAnSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVfaEIPA 80
Cdd:PRK14973 251 AYDATKEPLVVTEVKEghkvdRAPTPFDTTTFIVAA-SRLGFSAANAMRIAEDLYMNGYISYPRTDNTIYPKSL--DLNG 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 81 LIAFLHDHP-----VWGVHARRltelnAHSVDGKK-VTDHHALLITGKKPIDIFGEEV-VIYDMIAGRMLEAFSARCVKD 153
Cdd:PRK14973 328 VLATLAKGAfskdvAWVKDNRR-----PVPTRGKKsSTDHPPIHPTGVATREELGDDRwKLYELVVRRFLATLSPDAEWA 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 154 VSTVTAVCEGVKFILKGEIIKEEGWRTILKNSrkkdkeqaeaekrESRENgegiIIPQWEEGKQLPLCACSLTQGTTKPK 233
Cdd:PRK14973 403 TMKVNFDAGGEPYTATGGRLLEAGWRTVYPYS-------------EAKEN----ILPAFALGEKLPILAVNLEEKETQPP 465
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 234 PLHTESSLLAAMEtagkELedeelraqlkdcGIGTPATRAAIIETLFAREYMvrQKKSLVPTEKGLAVYSIVK--GMKIG 311
Cdd:PRK14973 466 ARYSQSRLIQRME----EL------------GLGTKSTRHEVIGKLVSRKYI--EGNPLRPTLVGRAVTESLEehAGTIT 527
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 312 NAEMTGQWEADLAKIERGELKERDFRKGIESYATQITDELlsskilfPKKQSDI---------------HCPKCGK---- 372
Cdd:PRK14973 528 EPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAFDEL-------EANEAVIgrdimertaeeltigPCPVCGKdlri 600
|
410
....*....|....*..
gi 545423095 373 ---GSLVF-----YPRC 381
Cdd:PRK14973 601 khiGSSQFigcsgYPDC 617
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
2-290 |
1.44e-15 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 78.83 E-value: 1.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 2 KLRNASVATVE-TIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPA 80
Cdd:PTZ00407 297 KLNNCTGFSVPlEPKPQPSVVPPPQPFTMATAIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESALPDIYA 376
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 81 ---------LIAFLHDHPVWGVHARRLTEL----------NAHSVDGKKVTDHHALLITGkkpIDIFGEEVV-------I 134
Cdd:PTZ00407 377 avkkefgkeFLYRLEDRTVSAQEGKGSKKTgkkrstkqkkGADTPVGNVEDAHEAIRPTN---IDTTGESLSlspptraV 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 135 YDMI-----AGRMLEAFSARCVKDVSTVTAVCEGVKFILKGEIIKEEGW-RTILKNSRKKDKEQAEAEKRESRENGEGII 208
Cdd:PTZ00407 454 YDLVrrntlAVFMIPMKTEKIVATVKFTSGSGEKLEFELQGKRVVEPGWtRAFHKGDKGTTGPAEETDEDITAVEEGAPV 533
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 209 IP---------------QWEEGKQ---LPLCACSLTQGTTKPKPLHTESSLLaametagkeledeelrAQLKDCGIGTPA 270
Cdd:PTZ00407 534 VPslsqeefkaimnlrsQLGSGVQkgfFELRSPQVRENRPVPPLPHSEGTLI----------------EELKNNGVGRPS 597
|
330 340
....*....|....*....|
gi 545423095 271 TRAAIIETLFAREYMVRQKK 290
Cdd:PTZ00407 598 TYPMIVKTLLARGYIAVNPK 617
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
1-372 |
7.07e-06 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 48.32 E-value: 7.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 1 EKLRNASVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPA 80
Cdd:COG0551 242 KKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASALAAALLEEEGELLYTGGYIRYTRTPKSSEADA 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 81 LIAFLHDHPVWGVHARRLTELNAHSVDGKKVTDHHALLI-------TGKKPIDIFGEEVVIYDMIAGRMLEAFSARCVKD 153
Cdd:COG0551 322 LAALEALKKIAEEPPDERAKKKKKKAKKKKASEAKETTDhppipptTAAALLELLEDRKLLLELLVRRRFAAAADLAKVE 401
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 154 VSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAEKRESRENGEGIIIPQweegkqlplcacsltQGTTKPK 233
Cdd:COG0551 402 ELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEELLLEK---------------QTTTPPP 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 234 PLHTESSLLAAMETagkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAV---YSIVKGMKI 310
Cdd:COG0551 467 RYTTELLLKKLEEE-----------------GGGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVvllLLLPFPKLE 529
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545423095 311 GNAEMTGQWEADLAKIERGELKE---RDFRKGIESYATQITDELLSSKILFPKKQSDIHCPKCGK 372
Cdd:COG0551 530 DTTETAEEEEALLDKEEGKEDKVveiREEEYPFFKKLLEIAEEEGEEELSEEDEVLGEKCPKCGK 594
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
388-416 |
1.54e-03 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 36.69 E-value: 1.54e-03
10 20
....*....|....*....|....*....
gi 545423095 388 DCGLTLFRSVAGKSLTDEQLTQLAVNGET 416
Cdd:pfam13342 1 GCGFSIGKTIAGKKLSEEQVKELLTKGKT 29
|
|
|