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Conserved domains on  [gi|545423095|ref|WP_021661814|]
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DNA topoisomerase, partial [Porphyromonas gingivalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Topoisom_bac super family cl38027
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 1-338 3.00e-104

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


The actual alignment was detected with superfamily member pfam01131:

Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 314.57  E-value: 3.00e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDvfAEIP 79
Cdd:pfam01131 101 EKLKKGT-AVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDD--ATLK 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   80 ALIAFL-HDHPVWGVHARRLTELNA--HSVDGKKVTDHHALLITGKKPIDIF--GEEVVIYDMIAGRMLEAFSARCVKDV 154
Cdd:pfam01131 178 AILEYLtKNYGKYLPYAPRLLKKTKgkLTVGNAKVTAHEAIRPTGDIPVLPElsDDERKLYELIVRRFLASQMPPAVYET 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  155 STVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKP 234
Cdd:pfam01131 258 TTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEE----------------ELPELKEGEELKVTQVEVEEKKTKPPP 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  235 LHTESSLLAAMETagkeledeelraqlkdCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM-KIGNA 313
Cdd:pfam01131 322 RYTEASLIKAMEK----------------AGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEALEKFpDLVDP 385

                         330       340
                  ....*....|....*....|....*
gi 545423095  314 EMTGQWEADLAKIERGELKERDFRK 338
Cdd:pfam01131 386 ELTAELEEKLDEIAEGKLDWKDVLA 410
Toprim_Crpt super family cl16247
C-terminal repeat of topoisomerase;
388-416 1.54e-03

C-terminal repeat of topoisomerase;


The actual alignment was detected with superfamily member pfam13342:

Pssm-ID: 463851 [Multi-domain]  Cd Length: 60  Bit Score: 36.69  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*....
gi 545423095  388 DCGLTLFRSVAGKSLTDEQLTQLAVNGET 416
Cdd:pfam13342   1 GCGFSIGKTIAGKKLSEEQVKELLTKGKT 29
 
Name Accession Description Interval E-value
Topoisom_bac pfam01131
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 1-338 3.00e-104

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 314.57  E-value: 3.00e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDvfAEIP 79
Cdd:pfam01131 101 EKLKKGT-AVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDD--ATLK 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   80 ALIAFL-HDHPVWGVHARRLTELNA--HSVDGKKVTDHHALLITGKKPIDIF--GEEVVIYDMIAGRMLEAFSARCVKDV 154
Cdd:pfam01131 178 AILEYLtKNYGKYLPYAPRLLKKTKgkLTVGNAKVTAHEAIRPTGDIPVLPElsDDERKLYELIVRRFLASQMPPAVYET 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  155 STVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKP 234
Cdd:pfam01131 258 TTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEE----------------ELPELKEGEELKVTQVEVEEKKTKPPP 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  235 LHTESSLLAAMETagkeledeelraqlkdCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM-KIGNA 313
Cdd:pfam01131 322 RYTEASLIKAMEK----------------AGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEALEKFpDLVDP 385

                         330       340
                  ....*....|....*....|....*
gi 545423095  314 EMTGQWEADLAKIERGELKERDFRK 338
Cdd:pfam01131 386 ELTAELEEKLDEIAEGKLDWKDVLA 410
PRK07726 PRK07726
DNA topoisomerase 3;
9-390 3.41e-95

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 299.00  E-value: 3.41e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   9 ATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKA-YITYPRTGSRHIPEDVFAEIPALI-AFLH 86
Cdd:PRK07726 263 AKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYETHkLITYPRTDSRYLPEDMVATLPEVLnAISK 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  87 DHPVWGVHARRL-TELNAHSVDGKKVTDHHALLITGKKPiDIF---GEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCE 162
Cdd:PRK07726 343 VDPYLLLAPPVLdPSIRSRAWNDKKVTAHHAIIPTEQPP-NLSklsEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIA 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 163 GVKFILKGEIIKEEGWRTILKNSRKKDKEQAeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLL 242
Cdd:PRK07726 422 GGTFIAKGKQVVEAGWKALLGKKEEDEEKEQ--------------PLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLL 487

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 243 AAMETAGKELEDEELRAQLKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVkGMKIGNAEMTGQWEA 321
Cdd:PRK07726 488 SAMENIARFVQDKELKKTLKETdGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLIDAL-PEELTSPDMTAKWEQ 566

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545423095 322 DLAKIERGELKERDFRKGIESYATQITDELLSSKILF----PKKQSdihCPKCGKGSLVFYPR---CAKCSDADCG 390
Cdd:PRK07726 567 ALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYkfdnLTGPK---CPDCGKPMLKVKGKngkMLVCQDRECG 639
TopA COG0550
DNA topoisomerase IA [Replication, recombination and repair];
1-349 1.40e-91

DNA topoisomerase IA [Replication, recombination and repair];


Pssm-ID: 440316 [Multi-domain]  Cd Length: 541  Bit Score: 286.22  E-value: 1.40e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPA 80
Cdd:COG0550  224 AALKGKT-FTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSEDAVAAARE 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  81 LIA------FLHDHPvwgvharrltelNAHSVDGKKVTDHHALLITG--KKPIDIFGEEVVIYDMIAGRMLEAFSARCVK 152
Cdd:COG0550  303 YIEalygkeYLPEKP------------RVYKTSKNAQEAHEAIRPTGvtRTPESLSGDEFKLYDLIWKRFLASQMPPAEY 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 153 DVSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAekresrengegiIIPQWEEGKQLPLCACSLTQGTTKP 232
Cdd:COG0550  371 ETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEEEEK------------RLPPLKEGEKLKLKKIEPEQHFTKP 438

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 233 KPLHTESSLLAAMETAgkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KI 310
Cdd:COG0550  439 PPRYTEASLVKAMEEL----------------GIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHfpDL 502

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 545423095 311 GNAEMTGQWEADLAKIERGELKERDFRKGIESYATQITD 349
Cdd:COG0550  503 VDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 7-336 1.14e-80

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 253.30  E-value: 1.14e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   7 SVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEipALIAFLH 86
Cdd:cd00186   67 KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILE--AREYIQA 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  87 DHPVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKPIDIF-----GEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVC 161
Cdd:cd00186  145 IYGKEYLYPAPLLGRRNPKRGKKEQGAHEAIRPTKVAPTPELeanlsEDEFKLYELIWRRFLASQMADAKYEETTVTLEI 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 162 EGVKFILKGEIIKEEGWRTILKNSRKKDKEQAeaekresrengegiiiPQWEEGKQLPLCACSLTQGTTKPKPLHTESSL 241
Cdd:cd00186  225 GGEKFKASGKVLLEDGWLEVYPEEKDDEEEEP----------------PPLKEGDELKLEEVELEEKETQPPPRYTEASL 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 242 LAAMETAgkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KIGNAEMTGQW 319
Cdd:cd00186  289 IKLMEKR----------------GIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHfpELVDPEFTAKL 352

                        330
                 ....*....|....*..
gi 545423095 320 EADLAKIERGELKERDF 336
Cdd:cd00186  353 EEKLDEIAEGKKDYQEV 369
topB TIGR01056
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ...
 9-382 5.80e-75

DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273419 [Multi-domain]  Cd Length: 660  Bit Score: 246.29  E-value: 5.80e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    9 ATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDVFAEIPALIAFLHD 87
Cdd:TIGR01056 266 ALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYEThKLITYPRTDSRYLPEDEKEMLLEVLDALKV 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   88 H-PVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKP--IDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGV 164
Cdd:TIGR01056 346 ItPALLPIKKRDELTNNRLWNDKKIEDHHAIIPTGNDFnlSDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKL 425

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  165 KFILKGEIIKEEGWRTILkNSRKKDKEQaeaekresrengEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAA 244
Cdd:TIGR01056 426 MFEAKGKILQDNGWKALL-GKQEEDEET------------EDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSA 492

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  245 METAGKELEDEELRAQLKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGMkIGNAEMTGQWEADL 323
Cdd:TIGR01056 493 MTNPAAFVQDKGLKKTLKETkGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLLCLLLPEL-LTKPDLTAQWEQYL 571

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 545423095  324 AKIERGELKERDFRKGIESYATQITDELLSSKILFPKKQSdihcPKCGKGSLVFYPRCA 382
Cdd:TIGR01056 572 NGISAGEKDDDDFINTINEMIKQTINEEKKNPETIQKVAK----EPVSCGGIAKCPAKD 626
TOP1Ac smart00437
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ...
 16-301 4.53e-68

Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit


Pssm-ID: 214663 [Multi-domain]  Cd Length: 259  Bit Score: 216.34  E-value: 4.53e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    16 RKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPALIAFlHDHPVWGVHA 95
Cdd:smart00437   2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQK-LYGKEYLDLA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    96 RRLTELNAHSVDGKKVTDHHALLITGKKP-----IDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGVKFILKG 170
Cdd:smart00437  81 VVLLKPRKPRKGKKAQGAHEAIRPTKPIFtpeleKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   171 EIIKEEGWRTILKNSRKkdkeqaeaekresrenGEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAAMETAgk 250
Cdd:smart00437 161 KTLLFDGWLKVYPEEKK----------------EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKR-- 222

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 545423095   251 eledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAV 301
Cdd:smart00437 223 --------------GIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
Toprim_Crpt pfam13342
C-terminal repeat of topoisomerase;
388-416 1.54e-03

C-terminal repeat of topoisomerase;


Pssm-ID: 463851 [Multi-domain]  Cd Length: 60  Bit Score: 36.69  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*....
gi 545423095  388 DCGLTLFRSVAGKSLTDEQLTQLAVNGET 416
Cdd:pfam13342   1 GCGFSIGKTIAGKKLSEEQVKELLTKGKT 29
 
Name Accession Description Interval E-value
Topoisom_bac pfam01131
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 1-338 3.00e-104

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 314.57  E-value: 3.00e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDvfAEIP 79
Cdd:pfam01131 101 EKLKKGT-AVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGLITYPRTDSTYLSDD--ATLK 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   80 ALIAFL-HDHPVWGVHARRLTELNA--HSVDGKKVTDHHALLITGKKPIDIF--GEEVVIYDMIAGRMLEAFSARCVKDV 154
Cdd:pfam01131 178 AILEYLtKNYGKYLPYAPRLLKKTKgkLTVGNAKVTAHEAIRPTGDIPVLPElsDDERKLYELIVRRFLASQMPPAVYET 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  155 STVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKP 234
Cdd:pfam01131 258 TTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEE----------------ELPELKEGEELKVTQVEVEEKKTKPPP 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  235 LHTESSLLAAMETagkeledeelraqlkdCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM-KIGNA 313
Cdd:pfam01131 322 RYTEASLIKAMEK----------------AGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEALEKFpDLVDP 385

                         330       340
                  ....*....|....*....|....*
gi 545423095  314 EMTGQWEADLAKIERGELKERDFRK 338
Cdd:pfam01131 386 ELTAELEEKLDEIAEGKLDWKDVLA 410
PRK07726 PRK07726
DNA topoisomerase 3;
9-390 3.41e-95

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 299.00  E-value: 3.41e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   9 ATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKA-YITYPRTGSRHIPEDVFAEIPALI-AFLH 86
Cdd:PRK07726 263 AKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYETHkLITYPRTDSRYLPEDMVATLPEVLnAISK 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  87 DHPVWGVHARRL-TELNAHSVDGKKVTDHHALLITGKKPiDIF---GEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCE 162
Cdd:PRK07726 343 VDPYLLLAPPVLdPSIRSRAWNDKKVTAHHAIIPTEQPP-NLSklsEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIA 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 163 GVKFILKGEIIKEEGWRTILKNSRKKDKEQAeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLL 242
Cdd:PRK07726 422 GGTFIAKGKQVVEAGWKALLGKKEEDEEKEQ--------------PLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLL 487

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 243 AAMETAGKELEDEELRAQLKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVkGMKIGNAEMTGQWEA 321
Cdd:PRK07726 488 SAMENIARFVQDKELKKTLKETdGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLIDAL-PEELTSPDMTAKWEQ 566

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545423095 322 DLAKIERGELKERDFRKGIESYATQITDELLSSKILF----PKKQSdihCPKCGKGSLVFYPR---CAKCSDADCG 390
Cdd:PRK07726 567 ALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYkfdnLTGPK---CPDCGKPMLKVKGKngkMLVCQDRECG 639
TopA COG0550
DNA topoisomerase IA [Replication, recombination and repair];
1-349 1.40e-91

DNA topoisomerase IA [Replication, recombination and repair];


Pssm-ID: 440316 [Multi-domain]  Cd Length: 541  Bit Score: 286.22  E-value: 1.40e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPA 80
Cdd:COG0550  224 AALKGKT-FTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSEDAVAAARE 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  81 LIA------FLHDHPvwgvharrltelNAHSVDGKKVTDHHALLITG--KKPIDIFGEEVVIYDMIAGRMLEAFSARCVK 152
Cdd:COG0550  303 YIEalygkeYLPEKP------------RVYKTSKNAQEAHEAIRPTGvtRTPESLSGDEFKLYDLIWKRFLASQMPPAEY 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 153 DVSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAekresrengegiIIPQWEEGKQLPLCACSLTQGTTKP 232
Cdd:COG0550  371 ETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEEEEK------------RLPPLKEGEKLKLKKIEPEQHFTKP 438

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 233 KPLHTESSLLAAMETAgkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KI 310
Cdd:COG0550  439 PPRYTEASLVKAMEEL----------------GIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHfpDL 502

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 545423095 311 GNAEMTGQWEADLAKIERGELKERDFRKGIESYATQITD 349
Cdd:COG0550  503 VDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 7-336 1.14e-80

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 253.30  E-value: 1.14e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   7 SVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEipALIAFLH 86
Cdd:cd00186   67 KEAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRTDSTRLSEEAILE--AREYIQA 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  87 DHPVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKPIDIF-----GEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVC 161
Cdd:cd00186  145 IYGKEYLYPAPLLGRRNPKRGKKEQGAHEAIRPTKVAPTPELeanlsEDEFKLYELIWRRFLASQMADAKYEETTVTLEI 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 162 EGVKFILKGEIIKEEGWRTILKNSRKKDKEQAeaekresrengegiiiPQWEEGKQLPLCACSLTQGTTKPKPLHTESSL 241
Cdd:cd00186  225 GGEKFKASGKVLLEDGWLEVYPEEKDDEEEEP----------------PPLKEGDELKLEEVELEEKETQPPPRYTEASL 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 242 LAAMETAgkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KIGNAEMTGQW 319
Cdd:cd00186  289 IKLMEKR----------------GIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHfpELVDPEFTAKL 352

                        330
                 ....*....|....*..
gi 545423095 320 EADLAKIERGELKERDF 336
Cdd:cd00186  353 EEKLDEIAEGKKDYQEV 369
PRK08173 PRK08173
DNA topoisomerase III; Validated
 17-415 1.92e-77

DNA topoisomerase III; Validated


Pssm-ID: 236172 [Multi-domain]  Cd Length: 862  Bit Score: 256.52  E-value: 1.92e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  17 KETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDVFAEIPALIAFLHDHPVWGVHA 95
Cdd:PRK08173 281 KPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKQTLEMLKESNNYLPHA 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  96 RRLTE-----LNAHSVDGKKVTDHHALLITGKKPIDIFGEEVVIYDMIAGRMLEAFSARCVKDVST-VTAVcEGVKFILK 169
Cdd:PRK08173 361 KQILDkgwvkPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTrITEV-AGHHFKTE 439

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 170 GEIIKEEGWRTILKnsrkkdkeqaeaeKRESRENGEGIIIPQWEEGKQLPLCACSLTqgtTKPKPLHTESSLLAAMETAG 249
Cdd:PRK08173 440 GKVLVNPGWLAVYG-------------KEAQGADANLVPVQKGEKVKTDKIEAVALT---TKPPARYNEATLLSAMEGAG 503

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 250 KELEDEELRAQLKDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGMKIG---NAEMTGQWEADLAKI 326
Cdd:PRK08173 504 KLVEDDELREAMAEKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVEeltSPELTGEWEYKLSQI 583

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 327 ERGELKERDFRKGIESYATQITD---ELLSSKILFPKKQSDIHCPKCGKGSLVFYPRCAkCSdaDCGLTLFRSVAGKSLT 403
Cdd:PRK08173 584 ERGKLSRDAFMQEIAQMTQQIVKrakEYDSDTIPGDYATLQTPCPNCGGVVKENYRRFA-CT--KCDFSISKIPGGRQFE 660

                        410
                 ....*....|..
gi 545423095 404 DEQLTQLAVNGE 415
Cdd:PRK08173 661 IAEVEELLRKKE 672
topB TIGR01056
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ...
 9-382 5.80e-75

DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273419 [Multi-domain]  Cd Length: 660  Bit Score: 246.29  E-value: 5.80e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    9 ATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDVFAEIPALIAFLHD 87
Cdd:TIGR01056 266 ALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYEThKLITYPRTDSRYLPEDEKEMLLEVLDALKV 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   88 H-PVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKP--IDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGV 164
Cdd:TIGR01056 346 ItPALLPIKKRDELTNNRLWNDKKIEDHHAIIPTGNDFnlSDLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKL 425

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  165 KFILKGEIIKEEGWRTILkNSRKKDKEQaeaekresrengEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAA 244
Cdd:TIGR01056 426 MFEAKGKILQDNGWKALL-GKQEEDEET------------EDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSA 492

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  245 METAGKELEDEELRAQLKDC-GIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGMkIGNAEMTGQWEADL 323
Cdd:TIGR01056 493 MTNPAAFVQDKGLKKTLKETkGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLLCLLLPEL-LTKPDLTAQWEQYL 571

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 545423095  324 AKIERGELKERDFRKGIESYATQITDELLSSKILFPKKQSdihcPKCGKGSLVFYPRCA 382
Cdd:TIGR01056 572 NGISAGEKDDDDFINTINEMIKQTINEEKKNPETIQKVAK----EPVSCGGIAKCPAKD 626
TOP1Ac smart00437
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ...
 16-301 4.53e-68

Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit


Pssm-ID: 214663 [Multi-domain]  Cd Length: 259  Bit Score: 216.34  E-value: 4.53e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    16 RKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPALIAFlHDHPVWGVHA 95
Cdd:smart00437   2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQK-LYGKEYLDLA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095    96 RRLTELNAHSVDGKKVTDHHALLITGKKP-----IDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGVKFILKG 170
Cdd:smart00437  81 VVLLKPRKPRKGKKAQGAHEAIRPTKPIFtpeleKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   171 EIIKEEGWRTILKNSRKkdkeqaeaekresrenGEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAAMETAgk 250
Cdd:smart00437 161 KTLLFDGWLKVYPEEKK----------------EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKR-- 222

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 545423095   251 eledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAV 301
Cdd:smart00437 223 --------------GIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
PRK14724 PRK14724
DNA topoisomerase III; Provisional
 17-410 7.04e-65

DNA topoisomerase III; Provisional


Pssm-ID: 237803 [Multi-domain]  Cd Length: 987  Bit Score: 224.06  E-value: 7.04e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  17 KETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK-AYITYPRTGSRHIPEDVFAEIPALIAFLHDHPVWGVHA 95
Cdd:PRK14724 289 KPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDYLPVAKQTFEMLATSGMRHLAP 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  96 RRLTELNAHSV-------DGKKVTDHHALLITGKKPIDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVCEGVKFIL 168
Cdd:PRK14724 369 FAQQALDGNYVrpskrifDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKT 448

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 169 KGEIIKEEGWRTILKnsrkkdkEQAEAEKRESRENGEGIIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLAAMETA 248
Cdd:PRK14724 449 EGKVLVKPGWLAIYG-------KEAANEVEDAKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMESA 521

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 249 GKELEDEELRAQLKDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM---KIGNAEMTGQWEADLAK 325
Cdd:PRK14724 522 GKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLgveELSRAELTGEWEYKLAQ 601

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 326 IERGELKERDFRKGIESYATQITDELLS-SKILFPKKQSDIH--CPKCGKGSLVFYPRCAkCSDAD-----CGLTLFRSV 397
Cdd:PRK14724 602 MEKGQLSREAFMQQIAAMTEKLVKKAKEyDRDTIPGDYATLStpCPNCGGVVKENYRRYA-CTGANgagegCGFSFTKSP 680

                        410
                 ....*....|...
gi 545423095 398 AGKSLTDEQLTQL 410
Cdd:PRK14724 681 AGRTFETAEAEQL 693
PRK07219 PRK07219
DNA topoisomerase I; Validated
 1-372 1.53e-49

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 179.43  E-value: 1.53e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   1 EKLRNASVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVfaEIPA 80
Cdd:PRK07219 258 EKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDL--DPKE 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  81 LIAFLHDHPVWGVHARR-LTELNAHSVDGKK-VTDHHALLITGKKPI-DIFGEEVVIYDMIAGRMLEAFSARCVKDVSTV 157
Cdd:PRK07219 336 LLKKLSKKKEYGPYAESiLEQENIKPTEGKKeTTDHPPIHPVDVPKReELSDDEWKVYELIVRRFLATLADPAEWEYLKV 415

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 158 TAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiiIPQWEEGKQLPLCACSLTQGTTKPKPLHT 237
Cdd:PRK07219 416 ELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKE-----------------LPDLEEGEKLKVNKIEIEAKETQPPKRYT 478

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 238 ESSLLAAMEtagkeledeelraqlkDCGIGTPATRAAIIETLFAREYMVRQkKSLVPTEKGLAVYSIVKGM--KIGNAEM 315
Cdd:PRK07219 479 QSSLIKEME----------------KRGLGTKATRHDIIEKLYKRGYVIEG-DPPRPTDLGIAVIEALEKYapEIVSEEM 541

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545423095 316 TGQWEADLAKIERGE-------------LKE-----RDFRKGIESY-ATQITDELLSSKILFPkkqsdihCPKCGK 372
Cdd:PRK07219 542 TAQLEADMQAIEDGKkkkedvteesremLKEilselKEKRKEIGDHlAGSLKAENRSLKTIGK-------CPECGG 610
PRK05776 PRK05776
DNA topoisomerase I; Provisional
 1-371 1.10e-48

DNA topoisomerase I; Provisional


Pssm-ID: 235602 [Multi-domain]  Cd Length: 670  Bit Score: 175.57  E-value: 1.10e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   1 EKLRNASVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVfaEIPA 80
Cdd:PRK05776 252 EEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKTQSIAEDLYLDGLISYPRTNSQKLPPTL--NIRN 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  81 LIAFLHDHPVWG--VHA-RRLTELNAHSVDGKKvTD--HHALLITGKKPIDIFGEEVVIYDMIAGRMLEAFSARCVKDVS 155
Cdd:PRK05776 330 ILKGLSRSPQYRplVNLlLKETKGVLKPVQGPK-DDpaHPAIYPTGEPPKNLSKDEFKLYDLIVRRFLASFAAPAVLSNT 408

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 156 TVTAVCEGV--KFILKGEIIKEEGWRTILKNSRKKDKEqaeaekresrengegiiIPQWEEGKQLPLCACSLTQGTTKPK 233
Cdd:PRK05776 409 IVTLRVPGFplVFSASGQRIEERGWLKYYPFHKFDEEE-----------------LPLLKKGERVKIVDVKVRKSYTKPP 471

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 234 PLHTESSLLAAMEtagkeledeelraqlkDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGM--KIG 311
Cdd:PRK05776 472 SRYSKASLLKWME----------------SVGIGTEATRARIIETLFKRGYLTSNGKYIEVTPLGFGVAEVLEKYfpDIV 535

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545423095 312 NAEMTGQWEADLAKIERGELKERD--------FRKGIESYAT---QITDELLSS-KILFPKKQsdihCPKCG 371
Cdd:PRK05776 536 SVELTRDFEEKLEMIRTGKATREEvieeaketLNKLLEEFKKnkdEIGEELAKAlGLIKPVGK----CKICG 603
PRK06599 PRK06599
DNA topoisomerase I; Validated
 1-376 7.82e-40

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 150.78  E-value: 7.82e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   1 EKLRNASvATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYE--------KAYITYPRTGSRHIPE 72
Cdd:PRK06599 236 KALEGQA-YTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEgidlgegtVGLITYMRTDSVRLSN 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  73 DVFAEIPALI------AFLHDHPvwgvharrltelNAHSVDGKKVTD-HHALlitgkKPIDIF-----------GEEVVI 134
Cdd:PRK06599 315 EALDEARKYItkkygkEYLPAKP------------RVYKKKSKNAQEaHEAI-----RPTSINrtpeslkpyltPDQFKL 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 135 YDMI-----AGRMLEAfsarcVKDVSTVTAVCEGVKFILK--GEIIKEEGWRTILKNSRKKDKEQAEAekresrengegi 207
Cdd:PRK06599 378 YELIwkrtvASQMAPA-----ILDQTSVDIASENGKYVFRatGSVILFPGFLKVYGESKDDEEEDDEK------------ 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 208 IIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSLLaametagKELEDEelraqlkdcGIGTPATRAAIIETLFAREYMVR 287
Cdd:PRK06599 441 LLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLV-------KKLEEY---------GIGRPSTYASIISTLQDREYVEL 504

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 288 QKKSLVPTEKGLavysIVKGM------KIGNAEMTGQWEADLAKIERGE------LKE--RDFRKGIESYATQITDELLs 353
Cdd:PRK06599 505 EKKRFIPTDLGR----IVNDFlvehfpKYVDYDFTAGLEDELDEIAEGKkdwkpvLREfwEPFISNLEKVEEDVRTEKV- 579

                        410       420
                 ....*....|....*....|...
gi 545423095 354 skilfPKKQSDIHCPKCGKGSLV 376
Cdd:PRK06599 580 -----TQEETDETCPKCGGGPLV 597
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 1-373 8.67e-30

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 121.82  E-value: 8.67e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   1 EKLRNA--SVATVEtivRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEI 78
Cdd:PRK07561 246 AALEGArySVASVE---DKPTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYITYMRTDSTNLSQEAINAA 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  79 PALIA------FLHDHP-VWGVHAR---------RLTELNAHSVDGKKVTdhhallitgkkpidifGEEVVIYDMI---- 138
Cdd:PRK07561 323 RGYIGdnygkkYLPEKPrQYSSKAKnaqeaheaiRPSDVFRTPDQLKGLE----------------GDAQRLYELIwkrf 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 139 -AGRMLEAfsarcVKDVSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAekresrengegiIIPQWEEGKQ 217
Cdd:PRK07561 387 vASQMAPA-----RYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRDDALDDEDR------------RLPALKVGDA 449

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 218 LPLCACSLTQGTTKPKPLHTESSLLaametagKELEDEelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEK 297
Cdd:PRK07561 450 LTLEKLDPTQHFTKPPARYSEASLV-------KELEKL---------GIGRPSTYASIISTIQDRGYVRLENRRFYPEKM 513

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 298 GLAV-------------YSIVKGMkignaemtgqwEADLAKIERGE------LKE--RDFRKGIESyatqiTDELLSSKI 356
Cdd:PRK07561 514 GRIVtdrleeffprlvdYDFTARM-----------EEELDDIANGEadwkpvLDDfyKDFSQQLEK-----AEELREEGG 577

                        410
                 ....*....|....*....
gi 545423095 357 LFP--KKQSDIHCPKCGKG 373
Cdd:PRK07561 578 MRPnqMVITDRDCPTCGRG 596
PRK06319 PRK06319
DNA topoisomerase I/SWI domain fusion protein; Validated
 1-376 6.60e-27

DNA topoisomerase I/SWI domain fusion protein; Validated


Pssm-ID: 235778 [Multi-domain]  Cd Length: 860  Bit Score: 113.38  E-value: 6.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   1 EKLRNASVaTVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYE---------KAYITYPRTGSRHIP 71
Cdd:PRK06319 246 ELLESATY-TVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYEgvdldsegaTGLITYMRTDSVRTD 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  72 EDVFAEIPALIA------FLHDHPvwGVHARRLTELNAHsvDGKKVTDHHalLITGKKPIDIFGEEVVIYDMIAGRMLEA 145
Cdd:PRK06319 325 PEALKQVRKYIEgtfgkeFLPSSP--NVYTTKKMAQDAH--EAIRPTDIT--LTPEKLRSKLTEDQYKLYSLIWKRFVAS 398

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 146 FSARCVKDVSTVTaVCEGVKFILK--GEIIKEEGWRTILKnsRKKDKEQAEAEkresrengeGIIIPQWEEGKQLPLCAC 223
Cdd:PRK06319 399 QMIPAIYDTLAIR-ITTNKGIDLRatGSLLKFKGFLAVYE--EKRDDEGDEEE---------NIHLPKLHEQDVLTKEEL 466

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 224 SLTQGTTKPKPLHTESSLLaametagKELEDEelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYS 303
Cdd:PRK06319 467 SAEQAFTKPLPRFTEASLV-------KELEKS---------GIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIISQ 530

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 304 IV-----KGMKIGnaeMTGQWEADLAKIERgelKERDFRKGIESYATQI--TDELLSSKILFPKKQSDIHCPKCGKGSLV 376
Cdd:PRK06319 531 FLetnfpRIMDIG---FTALMEDELELIAD---NKKPWKLLLQEFWELFlpVVVTAEKEAFIPRIVTEIDCPKCHKGKLV 604
PRK07220 PRK07220
DNA topoisomerase I; Validated
 7-372 6.09e-26

DNA topoisomerase I; Validated


Pssm-ID: 180892 [Multi-domain]  Cd Length: 740  Bit Score: 110.23  E-value: 6.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   7 SVATVETIVRKETRQEPPLLYDLTTLQKEANSrFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVfaEIPALIAFLH 86
Cdd:PRK07220 258 KTAEVTEVEKGTKTDKPPTPFNTTEFISAANS-IGFSAANAMRIAESLYTNGYISYPRTDNTVYPESL--DLREQIEIFA 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  87 DHPVwGVHARRLteLNAHSV---DGKK-VTDHHALLITGK-KPIDIFGEEVVIYDMIAGRMLEAFSARCVKDVSTVTAVC 161
Cdd:PRK07220 335 EGPF-GEYAQKL--LEKGELvptRGKKeTTDHPPIYPASLaKKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDI 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 162 EGVKFILKGEIIKEEGWRTILKNSRKKDKeqaeaekresrengegiIIPQWEEGKQLPLCACSLTQGTTKPKPLHTESSL 241
Cdd:PRK07220 412 GGEEFRANGSRLTEPGWRWYYPYNAPEDR-----------------LLPELSEGEELKVKKKEMLDKETQPPGRYGQGRL 474

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 242 LAAMEtagkeledeelraqlkDCGIGTPATRAAIIETLFAREYMvrQKKSLVPTEKGLAVysiVKGMK-----IGNAEMT 316
Cdd:PRK07220 475 IKLME----------------DLGLGTKATRHEIISKLYSRAYI--HGNPIQPTNTAFAV---VDALEkyaptITKPDMT 533

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545423095 317 GQWEADLAKIERGELKERDFRKGIESYATQITDELLSSK-----ILFPKKQSDI---HCPKCGK 372
Cdd:PRK07220 534 SRLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDKNRekireSLREGLREDKiigKCPLCGS 597
PRK08780 PRK08780
DNA topoisomerase I; Provisional
 8-330 4.97e-25

DNA topoisomerase I; Provisional


Pssm-ID: 181555 [Multi-domain]  Cd Length: 780  Bit Score: 107.54  E-value: 4.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   8 VATVEtivRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEK---------AYITYPRTGSRHIPEDVFAEI 78
Cdd:PRK08780 248 VTDVE---SKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQKLYEGvdlgdegsvGLITYMRTDSVNLSQDALAEI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  79 PALIA------FLHDHPvwgvharrltelNAHSVDGKKVTD-HHALLITG--KKPIDIFG----EEVVIYDMI-----AG 140
Cdd:PRK08780 325 RDVIArdygtaSLPDQP------------NTYKTKSKNAQEaHEAVRPTSalRTPAQVARflsdDQRRLYELIwkravAC 392

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 141 RMLEAfsarCVKDVSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAEKResrengegiIIPQWEEGKQLPL 220
Cdd:PRK08780 393 QMIPA----TLNTVSVDLAAGSEHVFRATGSTVVVPGFLAVYEEGKDDKSAEDEDEGR---------KLPPMKEGDNVPL 459

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 221 CACSLTQGTTKPKPLHTESSLLAAMEtagkeledeelraqlkDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLA 300
Cdd:PRK08780 460 ERIRAEQHFTEPPPRYTEASLVKALE----------------EYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRA 523

                        330       340       350
                 ....*....|....*....|....*....|..
gi 545423095 301 VYSIVKGM--KIGNAEMTGQWEADLAKIERGE 330
Cdd:PRK08780 524 VNKFLTGHftRYVDYDFTARLEDDLDAVSRGE 555
PRK14973 PRK14973
DNA topoisomerase I; Provisional
 6-381 5.34e-18

DNA topoisomerase I; Provisional


Pssm-ID: 184936 [Multi-domain]  Cd Length: 936  Bit Score: 86.44  E-value: 5.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   6 ASVATVETIVRKETRQ-----EPPLLYDLTTLQKEAnSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVfaEIPA 80
Cdd:PRK14973 251 AYDATKEPLVVTEVKEghkvdRAPTPFDTTTFIVAA-SRLGFSAANAMRIAEDLYMNGYISYPRTDNTIYPKSL--DLNG 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  81 LIAFLHDHP-----VWGVHARRltelnAHSVDGKK-VTDHHALLITGKKPIDIFGEEV-VIYDMIAGRMLEAFSARCVKD 153
Cdd:PRK14973 328 VLATLAKGAfskdvAWVKDNRR-----PVPTRGKKsSTDHPPIHPTGVATREELGDDRwKLYELVVRRFLATLSPDAEWA 402

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 154 VSTVTAVCEGVKFILKGEIIKEEGWRTILKNSrkkdkeqaeaekrESRENgegiIIPQWEEGKQLPLCACSLTQGTTKPK 233
Cdd:PRK14973 403 TMKVNFDAGGEPYTATGGRLLEAGWRTVYPYS-------------EAKEN----ILPAFALGEKLPILAVNLEEKETQPP 465

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 234 PLHTESSLLAAMEtagkELedeelraqlkdcGIGTPATRAAIIETLFAREYMvrQKKSLVPTEKGLAVYSIVK--GMKIG 311
Cdd:PRK14973 466 ARYSQSRLIQRME----EL------------GLGTKSTRHEVIGKLVSRKYI--EGNPLRPTLVGRAVTESLEehAGTIT 527

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 312 NAEMTGQWEADLAKIERGELKERDFRKGIESYATQITDELlsskilfPKKQSDI---------------HCPKCGK---- 372
Cdd:PRK14973 528 EPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAFDEL-------EANEAVIgrdimertaeeltigPCPVCGKdlri 600

                        410
                 ....*....|....*..
gi 545423095 373 ---GSLVF-----YPRC 381
Cdd:PRK14973 601 khiGSSQFigcsgYPDC 617
PTZ00407 PTZ00407
DNA topoisomerase IA; Provisional
 2-290 1.44e-15

DNA topoisomerase IA; Provisional


Pssm-ID: 173597 [Multi-domain]  Cd Length: 805  Bit Score: 78.83  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   2 KLRNASVATVE-TIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPA 80
Cdd:PTZ00407 297 KLNNCTGFSVPlEPKPQPSVVPPPQPFTMATAIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESALPDIYA 376

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  81 ---------LIAFLHDHPVWGVHARRLTEL----------NAHSVDGKKVTDHHALLITGkkpIDIFGEEVV-------I 134
Cdd:PTZ00407 377 avkkefgkeFLYRLEDRTVSAQEGKGSKKTgkkrstkqkkGADTPVGNVEDAHEAIRPTN---IDTTGESLSlspptraV 453

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 135 YDMI-----AGRMLEAFSARCVKDVSTVTAVCEGVKFILKGEIIKEEGW-RTILKNSRKKDKEQAEAEKRESRENGEGII 208
Cdd:PTZ00407 454 YDLVrrntlAVFMIPMKTEKIVATVKFTSGSGEKLEFELQGKRVVEPGWtRAFHKGDKGTTGPAEETDEDITAVEEGAPV 533

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 209 IP---------------QWEEGKQ---LPLCACSLTQGTTKPKPLHTESSLLaametagkeledeelrAQLKDCGIGTPA 270
Cdd:PTZ00407 534 VPslsqeefkaimnlrsQLGSGVQkgfFELRSPQVRENRPVPPLPHSEGTLI----------------EELKNNGVGRPS 597

                        330       340
                 ....*....|....*....|
gi 545423095 271 TRAAIIETLFAREYMVRQKK 290
Cdd:PTZ00407 598 TYPMIVKTLLARGYIAVNPK 617
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 1-372 7.07e-06

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 48.32  E-value: 7.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095   1 EKLRNASVATVETIVRKETRQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPA 80
Cdd:COG0551  242 KKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASALAAALLEEEGELLYTGGYIRYTRTPKSSEADA 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095  81 LIAFLHDHPVWGVHARRLTELNAHSVDGKKVTDHHALLI-------TGKKPIDIFGEEVVIYDMIAGRMLEAFSARCVKD 153
Cdd:COG0551  322 LAALEALKKIAEEPPDERAKKKKKKAKKKKASEAKETTDhppipptTAAALLELLEDRKLLLELLVRRRFAAAADLAKVE 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 154 VSTVTAVCEGVKFILKGEIIKEEGWRTILKNSRKKDKEQAEAEKRESRENGEGIIIPQweegkqlplcacsltQGTTKPK 233
Cdd:COG0551  402 ELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEELLLEK---------------QTTTPPP 466

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545423095 234 PLHTESSLLAAMETagkeledeelraqlkdcGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAV---YSIVKGMKI 310
Cdd:COG0551  467 RYTTELLLKKLEEE-----------------GGGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVvllLLLPFPKLE 529

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545423095 311 GNAEMTGQWEADLAKIERGELKE---RDFRKGIESYATQITDELLSSKILFPKKQSDIHCPKCGK 372
Cdd:COG0551  530 DTTETAEEEEALLDKEEGKEDKVveiREEEYPFFKKLLEIAEEEGEEELSEEDEVLGEKCPKCGK 594
Toprim_Crpt pfam13342
C-terminal repeat of topoisomerase;
388-416 1.54e-03

C-terminal repeat of topoisomerase;


Pssm-ID: 463851 [Multi-domain]  Cd Length: 60  Bit Score: 36.69  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*....
gi 545423095  388 DCGLTLFRSVAGKSLTDEQLTQLAVNGET 416
Cdd:pfam13342   1 GCGFSIGKTIAGKKLSEEQVKELLTKGKT 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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