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Conserved domains on  [gi|545193796|ref|XP_005602448|]
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ZW10 interactor isoform X1 [Equus caballus]

Protein Classification

ZW10 interactor( domain architecture ID 12173870)

ZW10 interactor (ZWINT) is involved in kinetochore formation and spindle checkpoint activity. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochore.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zwint pfam15556
ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are ...
 29-280 2.44e-126

ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.


:

Pssm-ID: 464766 [Multi-domain]  Cd Length: 252  Bit Score: 360.06  E-value: 2.44e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   29 QEEAEVPAQILAEFVTDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 108
Cdd:pfam15556   1 QEEAELPAQILAEFVMDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  109 AITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQEKHLQHLAEVSAEVRERQTGMKQELERL 188
Cdd:pfam15556  81 AITSALTQALPKMEEAQRKRAQLQEALEQLQAKKQMAMEKLRTAQKQWQLQQEKHLQHLAEVSAEVRERQTGTQQELERL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  189 YQELGTLKQEAGQEREKLQRHQTFLQLLYTLQGKLLLPEAEAELPQERDLPEPKSQQVTQSWELNTGDTMERVGDVSSKA 268
Cdd:pfam15556 161 YQELGTLKQQAGQERDKLQRHQTFLQLLYTLQGKLLFPEAEAELPQKLDLPEDKSQQLTQPQEQNTGDTMGRDRAVSSKA 240

                         250
                  ....*....|..
gi 545193796  269 SGPPPIADASLP 280
Cdd:pfam15556 241 DGPQPAGDASLP 252
 
Name Accession Description Interval E-value
Zwint pfam15556
ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are ...
 29-280 2.44e-126

ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.


Pssm-ID: 464766 [Multi-domain]  Cd Length: 252  Bit Score: 360.06  E-value: 2.44e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   29 QEEAEVPAQILAEFVTDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 108
Cdd:pfam15556   1 QEEAELPAQILAEFVMDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  109 AITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQEKHLQHLAEVSAEVRERQTGMKQELERL 188
Cdd:pfam15556  81 AITSALTQALPKMEEAQRKRAQLQEALEQLQAKKQMAMEKLRTAQKQWQLQQEKHLQHLAEVSAEVRERQTGTQQELERL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  189 YQELGTLKQEAGQEREKLQRHQTFLQLLYTLQGKLLLPEAEAELPQERDLPEPKSQQVTQSWELNTGDTMERVGDVSSKA 268
Cdd:pfam15556 161 YQELGTLKQQAGQERDKLQRHQTFLQLLYTLQGKLLFPEAEAELPQKLDLPEDKSQQLTQPQEQNTGDTMGRDRAVSSKA 240

                         250
                  ....*....|..
gi 545193796  269 SGPPPIADASLP 280
Cdd:pfam15556 241 DGPQPAGDASLP 252
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
97-238 1.84e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   97 KELKATYQEHVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQ-EKHLQHLAEVSAEVR 175
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAElEAELERLDASSDDLA 688

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545193796  176 ---ERQTGMKQELERLYQELGTLKQEAGQEREKLQRHQtflQLLYTLQGKLLLPEAEAELPQERDL 238
Cdd:COG4913   689 aleEQLEELEAELEELEEELDELKGEIGRLEKELEQAE---EELDELQDRLEAAEDLARLELRALL 751
mukB PRK04863
chromosome partition protein MukB;
91-199 6.84e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.10  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   91 AAKEQWKEL--KATYQEHVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQkQWQLQQEKHLQHLA 168
Cdd:PRK04863  493 EAWDVARELlrRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELE-QLQEELEARLESLS 571

                          90       100       110
                  ....*....|....*....|....*....|.
gi 545193796  169 EVSAEVRERQTGMKQELERLYQELGTLKQEA 199
Cdd:PRK04863  572 ESVSEARERRMALRQQLEQLQARIQRLAARA 602
BAR_Bin3 cd07590
The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3; BAR domains are dimerization, ...
 97-190 1.34e-03

The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Bridging integrator 3 (Bin3) is widely expressed in many tissues except in the brain. It plays roles in regulating filamentous actin localization and in cell division. In humans, the Bin3 gene is located in chromosome 8p21.3, a region that is implicated in cancer suppression. Homozygous inactivation of the Bin3 gene in mice led to the development of cataracts and an increased likelihood of lymphomas during aging, suggesting a role for Bin3 in lens development and cancer suppression. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.


Pssm-ID: 153274  Cd Length: 225  Bit Score: 39.27  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  97 KELKATYQEHVEAITSA-------LTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQEKhlQHLAE 169
Cdd:cd07590   79 TQLDKTVQELVNLIQKTfieplkrLRSVFPSVNAAIKRREQSLQEYERLQAKVEKLAEKEKTGPNLAKLEQAE--KALAA 156

                         90       100
                 ....*....|....*....|.
gi 545193796 170 VSAEVRERQTGMKQELERLYQ 190
Cdd:cd07590  157 ARADFEKQNIKLLEELPKFYN 177
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 76-248 2.12e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796    76 LDPLASEDTSRQKAIAAKEQWKELKAT--------YQEHVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAE 147
Cdd:TIGR02168  202 LKSLERQAEKAERYKELKAELRELELAllvlrleeLREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEE 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   148 KLRVAQKQWQLQQ------EKHLQHLAEVSAEVRERQTGMKQELERLYQELGTLKQEAGQEREKLQRHQTFLQLLytlqg 221
Cdd:TIGR02168  282 EIEELQKELYALAneisrlEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL----- 356

                          170       180
                   ....*....|....*....|....*..
gi 545193796   222 KLLLPEAEAELPQERDLPEPKSQQVTQ 248
Cdd:TIGR02168  357 EAELEELEAELEELESRLEELEEQLET 383
 
Name Accession Description Interval E-value
Zwint pfam15556
ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are ...
 29-280 2.44e-126

ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.


Pssm-ID: 464766 [Multi-domain]  Cd Length: 252  Bit Score: 360.06  E-value: 2.44e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   29 QEEAEVPAQILAEFVTDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 108
Cdd:pfam15556   1 QEEAELPAQILAEFVMDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  109 AITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQEKHLQHLAEVSAEVRERQTGMKQELERL 188
Cdd:pfam15556  81 AITSALTQALPKMEEAQRKRAQLQEALEQLQAKKQMAMEKLRTAQKQWQLQQEKHLQHLAEVSAEVRERQTGTQQELERL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  189 YQELGTLKQEAGQEREKLQRHQTFLQLLYTLQGKLLLPEAEAELPQERDLPEPKSQQVTQSWELNTGDTMERVGDVSSKA 268
Cdd:pfam15556 161 YQELGTLKQQAGQERDKLQRHQTFLQLLYTLQGKLLFPEAEAELPQKLDLPEDKSQQLTQPQEQNTGDTMGRDRAVSSKA 240

                         250
                  ....*....|..
gi 545193796  269 SGPPPIADASLP 280
Cdd:pfam15556 241 DGPQPAGDASLP 252
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
97-238 1.84e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   97 KELKATYQEHVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQ-EKHLQHLAEVSAEVR 175
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAElEAELERLDASSDDLA 688

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545193796  176 ---ERQTGMKQELERLYQELGTLKQEAGQEREKLQRHQtflQLLYTLQGKLLLPEAEAELPQERDL 238
Cdd:COG4913   689 aleEQLEELEAELEELEEELDELKGEIGRLEKELEQAE---EELDELQDRLEAAEDLARLELRALL 751
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 79-238 7.42e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 7.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  79 LASEDTSRQKAIAAKEQWKELKATYQEHVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQL 158
Cdd:COG1196  304 IARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796 159 QQEKHLQHLAEVS------AEVRERQTGMKQELERLYQELGTLKQEAGQEREKLQRHQTFLQLLYTLQGKLLLPEAEAEL 232
Cdd:COG1196  384 LAEELLEALRAAAelaaqlEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463


                 ....*.
gi 545193796 233 PQERDL 238
Cdd:COG1196  464 LLAELL 469
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 87-248 5.58e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.56  E-value: 5.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   87 QKAIAAKEQWKELKATYQEhVEAITSALTQvLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQEKHLQH 166
Cdd:COG3096   495 QTARELLRRYRSQQALAQR-LQQLRAQLAE-LEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQ 572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  167 LaevsAEVRERQTGMKQELERLYQELGTLKQEA-----GQER-EKL--QRHQTFLQLLYTLQGKLLLPEAEAELPQERDL 238
Cdd:COG3096   573 A----AEAVEQRSELRQQLEQLRARIKELAARApawlaAQDAlERLreQSGEALADSQEVTAAMQQLLEREREATVERDE 648

                         170
                  ....*....|
gi 545193796  239 PEPKSQQVTQ 248
Cdd:COG3096   649 LAARKQALES 658
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
58-215 1.02e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  58 QVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQE--HVEAITSALTQVLPKVEEAQRKRAQLQEAL 135
Cdd:COG4717   86 KEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQEleALEAELAELPERLEELEERLEELRELEEEL 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796 136 EQLQAKKQVAAEKLRVAQKQWQLQQEKHLQHLAEVSAEVRERQTGMKQELERLYQELGTLKQEAGQEREKLQRHQTFLQL 215
Cdd:COG4717  166 EELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERL 245
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
80-232 1.55e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   80 ASEDTSRQKAIAAKEQWKELKATYQEH----VEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQ 155
Cdd:COG4913   309 AELERLEARLDALREELDELEAQIRGNggdrLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAE 388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  156 WQLQQEKhlqhLAEVSAEVRERQTGMKQELERLYQELGTLKQE-AGQEREKLQRHQTFLQLLYTLQGKLLLPEAE----A 230
Cdd:COG4913   389 AAALLEA----LEEELEALEEALAEAEAALRDLRRELRELEAEiASLERRKSNIPARLLALRDALAEALGLDEAElpfvG 464


                  ..
gi 545193796  231 EL 232
Cdd:COG4913   465 EL 466
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
86-232 1.62e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   86 RQKAIAAKEQWK---ELKATYQEHVEAITSALTQVLPK----VEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKqwql 158
Cdd:COG4913   241 HEALEDAREQIEllePIRELAERYAAARERLAELEYLRaalrLWFAQRRLELLEAELEELRAELARLEAELERLEA---- 316

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545193796  159 QQEKHLQHLAEVSAEVRERQTgmkQELERLYQELGTLKQEAGQEREKLQRHQTFLQLLytlqgKLLLPEAEAEL 232
Cdd:COG4913   317 RLDALREELDELEAQIRGNGG---DRLEQLEREIERLERELEERERRRARLEALLAAL-----GLPLPASAEEF 382
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
76-210 2.78e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   76 LDPLASEDTSRQKAIAAKEQWKELKATYQehVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQ 155
Cdd:COG4913   254 LEPIRELAERYAAARERLAELEYLRAALR--LWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQ 331

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 545193796  156 WQLQQEKHLQHLAEVSAEVRERQTGMKQELERLYQELGTLKQEAGQEREKLQRHQ 210
Cdd:COG4913   332 IRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALR 386
mukB PRK04863
chromosome partition protein MukB;
91-199 6.84e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.10  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   91 AAKEQWKEL--KATYQEHVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQkQWQLQQEKHLQHLA 168
Cdd:PRK04863  493 EAWDVARELlrRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELE-QLQEELEARLESLS 571

                          90       100       110
                  ....*....|....*....|....*....|.
gi 545193796  169 EVSAEVRERQTGMKQELERLYQELGTLKQEA 199
Cdd:PRK04863  572 ESVSEARERRMALRQQLEQLQARIQRLAARA 602
BAR_Bin3 cd07590
The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3; BAR domains are dimerization, ...
 97-190 1.34e-03

The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Bridging integrator 3 (Bin3) is widely expressed in many tissues except in the brain. It plays roles in regulating filamentous actin localization and in cell division. In humans, the Bin3 gene is located in chromosome 8p21.3, a region that is implicated in cancer suppression. Homozygous inactivation of the Bin3 gene in mice led to the development of cataracts and an increased likelihood of lymphomas during aging, suggesting a role for Bin3 in lens development and cancer suppression. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.


Pssm-ID: 153274  Cd Length: 225  Bit Score: 39.27  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  97 KELKATYQEHVEAITSA-------LTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQEKhlQHLAE 169
Cdd:cd07590   79 TQLDKTVQELVNLIQKTfieplkrLRSVFPSVNAAIKRREQSLQEYERLQAKVEKLAEKEKTGPNLAKLEQAE--KALAA 156

                         90       100
                 ....*....|....*....|.
gi 545193796 170 VSAEVRERQTGMKQELERLYQ 190
Cdd:cd07590  157 ARADFEKQNIKLLEELPKFYN 177
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 91-207 1.59e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796  91 AAKEQWKELKATYQEH---VEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQEKhLQHL 167
Cdd:COG1196  236 ELEAELEELEAELEELeaeLEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER-RREL 314

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 545193796 168 AEVSAEVRERQTGMKQELERLYQELGTLKQEAGQEREKLQ 207
Cdd:COG1196  315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
68-210 1.73e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.90  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   68 AQEDTAQGLDPLASEDTSRQKAIAAKEQ--WKELK-ATYQEHVEAITSALTQVL---PKVEEAQRKRAQLQEALEQLQAK 141
Cdd:COG4913   628 EAEERLEALEAELDALQERREALQRLAEysWDEIDvASAEREIAELEAELERLDassDDLAALEEQLEELEAELEELEEE 707

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545193796  142 KQVAAEKLRVAQKQWQLQQEKHLQHLAEVSAEVRERQTGMKQELERLYQELGTLKQEAgQEREKLQRHQ 210
Cdd:COG4913   708 LDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVER-ELRENLEERI 775
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 76-248 2.12e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796    76 LDPLASEDTSRQKAIAAKEQWKELKAT--------YQEHVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAE 147
Cdd:TIGR02168  202 LKSLERQAEKAERYKELKAELRELELAllvlrleeLREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEE 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796   148 KLRVAQKQWQLQQ------EKHLQHLAEVSAEVRERQTGMKQELERLYQELGTLKQEAGQEREKLQRHQTFLQLLytlqg 221
Cdd:TIGR02168  282 EIEELQKELYALAneisrlEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL----- 356

                          170       180
                   ....*....|....*....|....*..
gi 545193796   222 KLLLPEAEAELPQERDLPEPKSQQVTQ 248
Cdd:TIGR02168  357 EAELEELEAELEELESRLEELEEQLET 383
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 86-223 5.87e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.11  E-value: 5.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545193796    86 RQKAIAAKEQWKELKATYQEHVEAITSALTQVLPKVEEAQRKRAQLQEALEQLQakkQVAAEKLRVAQKQWQLQQEKHLQ 165
Cdd:TIGR02168  357 EAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLE---RLEDRRERLQQEIEELLKKLEEA 433

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 545193796   166 HLAEVSAEVRERQTGMKQELERLYQELGTLKQEAGQEREKLQRHQTFLQLLYTLQGKL 223
Cdd:TIGR02168  434 ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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