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MULTISPECIES: GntR family transcriptional regulator [Lactiplantibacillus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
42-271 1.28e-42

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 145.39  E-value: 1.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  42 VPLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEDIDLGIHYLD 121
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489 122 VRKAIENMNAVPEIRLEAFKLIVDGSEsdVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRIFNSEIVNND 201
Cdd:COG2188   84 FTEELRARGREPSTRVLSAERVPADEE--VAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGS 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544949489 202 LMPFLVKKYGLKASFFSHT-QPALITKSNRKEFDLNVGDPMIYMQTRGI-EEKEIIYYRKAAVVGNLIMYIV 271
Cdd:COG2188  162 LYELLEERYGLRITRAEQRiEAVLADAEEAELLGVPPGAPVLVIERVTYdADGRPVEYSRSYYRGDRYRFVV 233
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
42-271 1.28e-42

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 145.39  E-value: 1.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  42 VPLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEDIDLGIHYLD 121
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489 122 VRKAIENMNAVPEIRLEAFKLIVDGSEsdVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRIFNSEIVNND 201
Cdd:COG2188   84 FTEELRARGREPSTRVLSAERVPADEE--VAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGS 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544949489 202 LMPFLVKKYGLKASFFSHT-QPALITKSNRKEFDLNVGDPMIYMQTRGI-EEKEIIYYRKAAVVGNLIMYIV 271
Cdd:COG2188  162 LYELLEERYGLRITRAEQRiEAVLADAEEAELLGVPPGAPVLVIERVTYdADGRPVEYSRSYYRGDRYRFVV 233
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 43-108 8.47e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 88.66  E-value: 8.47e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544949489  43 PLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVK 108
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 44-107 2.13e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 66.10  E-value: 2.13e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544949489   44 LYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFV 107
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK11402 PRK11402
transcriptional regulator PhoB;
43-192 2.76e-14

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 70.25  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  43 PLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEdidlgihyldV 122
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQK----------V 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544949489 123 RKAIENMNAVPEIRLEAFK-----LIVDGSES--DVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRI 192
Cdd:PRK11402  79 ENALLTVSGFTDFGVSQGKatkekVIEQERVSaaPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDF 155
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
50-107 5.82e-14

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 64.90  E-value: 5.82e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 544949489    50 NDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFV 107
Cdd:smart00345   3 ERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 51-242 3.62e-13

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 67.00  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489   51 DLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEDIDLGI------HYLDVRK 124
Cdd:TIGR02404   8 DLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPIsgitsfKELNETL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  125 AIENMNAVPEIRLEAfklIVDGSESDVRKVMEINSDVYLYYLRYMvyaDHRPVFHEQVYLPFERFPRIFNsEIVNNDLMP 204
Cdd:TIGR02404  88 GLDSKTEVVELDKED---PLPETLAQLTGLEEGSLIWRIKRVRVI---DGEAVILDIDYLLKELVPGLTK-EIAEDSIYQ 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 544949489  205 FLVKKYGLKASFFSHTQPAL-ITKSNRKEFDLNVGDPMI 242
Cdd:TIGR02404 161 YLENELGLAISYAQKEITVEpCTDEDKKLLDLDGDDHVV 199
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
42-271 1.28e-42

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 145.39  E-value: 1.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  42 VPLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEDIDLGIHYLD 121
Cdd:COG2188    4 VPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489 122 VRKAIENMNAVPEIRLEAFKLIVDGSEsdVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRIFNSEIVNND 201
Cdd:COG2188   84 FTEELRARGREPSTRVLSAERVPADEE--VAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETGS 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544949489 202 LMPFLVKKYGLKASFFSHT-QPALITKSNRKEFDLNVGDPMIYMQTRGI-EEKEIIYYRKAAVVGNLIMYIV 271
Cdd:COG2188  162 LYELLEERYGLRITRAEQRiEAVLADAEEAELLGVPPGAPVLVIERVTYdADGRPVEYSRSYYRGDRYRFVV 233
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 43-108 8.47e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 88.66  E-value: 8.47e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544949489  43 PLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVK 108
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
44-127 6.91e-17

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 77.28  E-value: 6.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  44 LYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEDIDLG------- 116
Cdd:COG2186    8 LAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLdplalll 87

                         90
                 ....*....|....*...
gi 544949489 117 -------IHYLDVRKAIE 127
Cdd:COG2186   88 alddaslRDLLEARLALE 105
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
42-108 1.33e-15

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 70.98  E-value: 1.33e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544949489  42 VPLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVK 108
Cdd:COG1725    9 VPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVA 75
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 44-107 2.13e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 66.10  E-value: 2.13e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544949489   44 LYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFV 107
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK11402 PRK11402
transcriptional regulator PhoB;
43-192 2.76e-14

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 70.25  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  43 PLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEdidlgihyldV 122
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQK----------V 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544949489 123 RKAIENMNAVPEIRLEAFK-----LIVDGSES--DVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRI 192
Cdd:PRK11402  79 ENALLTVSGFTDFGVSQGKatkekVIEQERVSaaPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDF 155
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 43-107 4.47e-14

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 71.40  E-value: 4.47e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544949489  43 PLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFV 107
Cdd:COG1167   12 PLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFV 76
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
50-107 5.82e-14

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 64.90  E-value: 5.82e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 544949489    50 NDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFV 107
Cdd:smart00345   3 ERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 51-242 3.62e-13

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 67.00  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489   51 DLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEDIDLGI------HYLDVRK 124
Cdd:TIGR02404   8 DLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPIsgitsfKELNETL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  125 AIENMNAVPEIRLEAfklIVDGSESDVRKVMEINSDVYLYYLRYMvyaDHRPVFHEQVYLPFERFPRIFNsEIVNNDLMP 204
Cdd:TIGR02404  88 GLDSKTEVVELDKED---PLPETLAQLTGLEEGSLIWRIKRVRVI---DGEAVILDIDYLLKELVPGLTK-EIAEDSIYQ 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 544949489  205 FLVKKYGLKASFFSHTQPAL-ITKSNRKEFDLNVGDPMI 242
Cdd:TIGR02404 161 YLENELGLAISYAQKEITVEpCTDEDKKLLDLDGDDHVV 199
PRK09764 PRK09764
GntR family transcriptional regulator;
43-190 1.20e-12

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 65.62  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  43 PLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKnKEDIDLGIHYL-D 121
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK-EERVNYDIFQLtS 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544949489 122 VRKAIENMNAVPEIRLEAFKLIVdgSESDVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFP 190
Cdd:PRK09764  84 FDEKLSDRHVDTHSEVLIFEVIP--ADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFP 150
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 42-192 4.40e-12

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 64.03  E-value: 4.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489   42 VPLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKnKEDIDlgiHYLD 121
Cdd:TIGR02325   7 VALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVA-ARRID---YPLS 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544949489  122 VRKAI-ENMNA-VPEIRLEAFKLIVDGSESDVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRI 192
Cdd:TIGR02325  83 ARTRFsQNLADqGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGI 155
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
36-110 1.13e-10

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 60.42  E-value: 1.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  36 MASSKIvplYQSMLNDLIRQ-----IESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNK 110
Cdd:PRK09464   1 MAYSKI---RQPKLSDVIEQqleflILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 129-260 2.26e-10

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 57.30  E-value: 2.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489   129 MNAVPEIRLEAFKLIVDGSEsdVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRIfNSEIVNNDLMPFLVK 208
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEE--LAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGL-LEEDLSGSLYEYLEE 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 544949489   209 KYGLKASFFSHTQ----PALITKSNRKEFDLNVGDPMIYMQTRGI-EEKEIIYYRKA 260
Cdd:smart00866  79 RLGLKIVRSTRAEqtitAVLADEEEAELLGLPPGAPLLVVERVTYdDDGRPVEYSRS 135
PRK11523 PRK11523
transcriptional regulator ExuR;
36-157 1.86e-08

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 53.70  E-value: 1.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  36 MASSKIVPLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKEdidl 115
Cdd:PRK11523   1 MEITEPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQ---- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 544949489 116 GIHYLDVRKAIENMNAVPEIRLEAFKLIVDG---------SESDVRKVMEI 157
Cdd:PRK11523  77 PRHQQAADNNMEFANYGPFELLQARQLIESNiaefaatqvTKQDIMKLMAI 127
PRK14999 PRK14999
histidine utilization repressor; Provisional
 38-107 4.91e-08

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 52.63  E-value: 4.91e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  38 SSKIVPLYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFV 107
Cdd:PRK14999   7 RSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 44-94 6.20e-08

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 52.33  E-value: 6.20e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 544949489  44 LYQSMLNDLIRQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENK 94
Cdd:PRK03837  14 LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRK 64
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
34-127 7.99e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 51.46  E-value: 7.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  34 NKMASSKIVPLYQSMLNDLIRQIESGELVENAKLpSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVK--NKE 111
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAplSPE 80

                         90
                 ....*....|....*.
gi 544949489 112 DIDlgiHYLDVRKAIE 127
Cdd:COG1802   81 EIR---ELYEVRAALE 93
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 67-107 3.58e-07

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 49.77  E-value: 3.58e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 544949489  67 LPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFV 107
Cdd:PRK10079  35 LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 129-259 1.37e-06

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 46.82  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544949489  129 MNAVPEIRLEAFKLIVDGSEsdVRKVMEINSDVYLYYLRYMVYADHRPVFHEQVYLPFERFPRIFNSEIVNNDLMPFLVK 208
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAE--IAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 544949489  209 KYGLKASFFSHT-QPALITKSNRKEFDLNVGDPMIYMQTRGI-EEKEIIYYRK 259
Cdd:pfam07702  80 RYGLPITRAEQTiEAVLADAEEAELLGISPGAPVLLIERVTYdQDGRPVEYSR 132
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 48-108 5.19e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.60  E-value: 5.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544949489  48 MLNDLIRQ-----IESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVK 108
Cdd:PRK10421   2 RLSDEVADrvralIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIR 67
PRK10225 PRK10225
Uxu operon transcriptional regulator;
45-112 1.06e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 42.70  E-value: 1.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544949489  45 YQ---SMLNDLIRQI--ESGElvenaKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKNKED 112
Cdd:PRK10225  11 YQevgAMIRDLIIKTpyNPGE-----RLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSG 78
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 54-109 1.60e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 42.06  E-value: 1.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 544949489  54 RQIESGELVENAKLPSEQKLGEKYDVSRITVRRALAELENKDYIYKKQGQGSFVKN 109
Cdd:PRK09990  18 RLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR 73
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 71-104 3.91e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 34.72  E-value: 3.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 544949489   71 QKLGEKYDVSRITVRRALAELENK-DYIYKKQGQG 104
Cdd:pfam08279  17 QELAEKLGVSRRTIRRDIKILEELgVPIEAEPGRG 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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