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Conserved domains on  [gi|544709721|ref|NP_001269835|]
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AN1-type zinc finger protein 4 isoform b [Homo sapiens]

Protein Classification

Ubl1_cv_Nsp3_N-like and ZnF_AN1 domain-containing protein( domain architecture ID 13219323)

Ubl1_cv_Nsp3_N-like and ZnF_AN1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 593-631 1.68e-11

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


:

Pssm-ID: 197545  Cd Length: 39  Bit Score: 58.94  E-value: 1.68e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 544709721   593 CFLCGKKTGLASsYECR-CGNNFCASHRYAETHGCTYDYK 631
Cdd:smart00154   1 CHFCRKKVGLTG-FKCRhCGNLFCGEHRLPEDHDCPGDYK 39
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 1-27 2.87e-11

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd01802:

Pssm-ID: 475130 [Multi-domain]  Cd Length: 74  Bit Score: 59.65  E-value: 2.87e-11
                         10        20
                 ....*....|....*....|....*..
gi 544709721   1 MELENDYCLNDYNISEGCTLKLVLAMR 27
Cdd:cd01802   48 RELEDDYCLHDYNITDGSTLKLVLAMR 74
 
Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 593-631 1.68e-11

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


Pssm-ID: 197545  Cd Length: 39  Bit Score: 58.94  E-value: 1.68e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 544709721   593 CFLCGKKTGLASsYECR-CGNNFCASHRYAETHGCTYDYK 631
Cdd:smart00154   1 CHFCRKKVGLTG-FKCRhCGNLFCGEHRLPEDHDCPGDYK 39
Ubl_ZFAND4 cd01802
ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar ...
 1-27 2.87e-11

ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins; ZFAND4, also termed AN1-type zinc finger and ubiquitin domain-containing protein-like 1 (ANUBL1), may function as an oncogene that promotes proliferation and regulates relevant tumor suppressor genes in gastric cancer, suggesting a role in gastric cancer initiation and progression. ZFAND4contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal AN1-type zinc finger. Unlike ubiquitin polyproteins and most ubiquitin fusion proteins, the N-terminal Ubl domain of ZFAND4 does not undergo proteolytic processing.


Pssm-ID: 340500 [Multi-domain]  Cd Length: 74  Bit Score: 59.65  E-value: 2.87e-11
                         10        20
                 ....*....|....*....|....*..
gi 544709721   1 MELENDYCLNDYNISEGCTLKLVLAMR 27
Cdd:cd01802   48 RELEDDYCLHDYNITDGSTLKLVLAMR 74
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 596-628 4.95e-07

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 46.53  E-value: 4.95e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 544709721  596 CGKKTGLasSYECR-CGNNFCASHRYAETHGCTY 628
Cdd:pfam01428   6 CKKKDFL--PFKCRfCGKNFCLKHRLPEDHDCSG 37
 
Name Accession Description Interval E-value
ZnF_AN1 smart00154
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 593-631 1.68e-11

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis.


Pssm-ID: 197545  Cd Length: 39  Bit Score: 58.94  E-value: 1.68e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 544709721   593 CFLCGKKTGLASsYECR-CGNNFCASHRYAETHGCTYDYK 631
Cdd:smart00154   1 CHFCRKKVGLTG-FKCRhCGNLFCGEHRLPEDHDCPGDYK 39
Ubl_ZFAND4 cd01802
ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar ...
 1-27 2.87e-11

ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins; ZFAND4, also termed AN1-type zinc finger and ubiquitin domain-containing protein-like 1 (ANUBL1), may function as an oncogene that promotes proliferation and regulates relevant tumor suppressor genes in gastric cancer, suggesting a role in gastric cancer initiation and progression. ZFAND4contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal AN1-type zinc finger. Unlike ubiquitin polyproteins and most ubiquitin fusion proteins, the N-terminal Ubl domain of ZFAND4 does not undergo proteolytic processing.


Pssm-ID: 340500 [Multi-domain]  Cd Length: 74  Bit Score: 59.65  E-value: 2.87e-11
                         10        20
                 ....*....|....*....|....*..
gi 544709721   1 MELENDYCLNDYNISEGCTLKLVLAMR 27
Cdd:cd01802   48 RELEDDYCLHDYNITDGSTLKLVLAMR 74
zf-AN1 pfam01428
AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in ...
 596-628 4.95e-07

AN1-like Zinc finger; Zinc finger at the C-terminus of An1, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.


Pssm-ID: 460208  Cd Length: 37  Bit Score: 46.53  E-value: 4.95e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 544709721  596 CGKKTGLasSYECR-CGNNFCASHRYAETHGCTY 628
Cdd:pfam01428   6 CKKKDFL--PFKCRfCGKNFCLKHRLPEDHDCSG 37
Ubl_NEDD8 cd01806
ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally ...
 2-29 1.71e-03

ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins; NEDD8, also termed Neddylin, or RELATED TO UBIQUITIN (RUB/Rub1p) in plant and yeast, is a ubiquitin-like protein that conjugates to nuclear proteins in a manner analogous to ubiquitination and sentrinization. It modifies a family of molecular scaffold proteins called cullins that are responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. NEDD8 deamidation and its inhibition of Cullin-RING ubiquitin ligases (CRLs) activity are responsible for Cycle-inhibiting factor (Cif)/Cif homolog in Burkholderia pseudomallei (CHBP)-induced cytopathic effect. NEDD8 contains a single conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. Polyubiquitination, signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. Ubl NEDD8, contains many of the same lysines (K6, K11, K27, K33, K48) as Ub, where K27 has an role (other than conjugation) in the mechanism of protein neddylation.


Pssm-ID: 340504 [Multi-domain]  Cd Length: 74  Bit Score: 37.37  E-value: 1.71e-03
                         10        20
                 ....*....|....*....|....*...
gi 544709721   2 ELENDYCLNDYNISEGCTLKLVLAMRGG 29
Cdd:cd01806   47 QMNDEKTAADYKIEGGSVLHLVLALRGG 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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