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Conserved domains on  [gi|544583314|dbj|BAN84368|]
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cytochrome oxidase subunit I, partial (mitochondrion) [Astrophyton muricatum]

Protein Classification

cytochrome-c oxidase subunit 1( domain architecture ID 10009591)

cytochrome-c oxidase subunit 1 is the catalytic subunit of cytochrome c oxidase, which is the component of the respiratory chain that catalyzes the reduction of oxygen to water

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX1 MTH00153
cytochrome c oxidase subunit I; Provisional
 1-501 0e+00

cytochrome c oxidase subunit I; Provisional


:

Pssm-ID: 177210  Cd Length: 511  Bit Score: 845.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00153  12 DIGTLYFIFGAWSGMVGTSLSLLIRAELGQPGSLIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00153  92 FPRMNNMSFWLLPPSLTLLLSSSMVESGAGTGWTVYPPLSSNIAHSGASVDLAIFSLHLAGISSILGAINFITTIINMRS 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00153 172 KGMTLDRMPLFVWSVLITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGM 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:MTH00153 252 ISHIISQESGKKETFGTLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGSQIN 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INkihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00153 332 YS---PSLLWALGFVFLFTIGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFTGLTMNPKWL 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00153 409 KIQFFIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTSWNVISSIGSTISLISILFFIFIIWESMISKRPVLFSLNLSS 488

                        490       500
                 ....*....|....*....|.
gi 544583314 481 NLEWhYPIFPPQEHTFNETPL 501
Cdd:MTH00153 489 SIEW-LQNLPPAEHSYSELPL 508
 
Name Accession Description Interval E-value
COX1 MTH00153
cytochrome c oxidase subunit I; Provisional
 1-501 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177210  Cd Length: 511  Bit Score: 845.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00153  12 DIGTLYFIFGAWSGMVGTSLSLLIRAELGQPGSLIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00153  92 FPRMNNMSFWLLPPSLTLLLSSSMVESGAGTGWTVYPPLSSNIAHSGASVDLAIFSLHLAGISSILGAINFITTIINMRS 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00153 172 KGMTLDRMPLFVWSVLITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGM 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:MTH00153 252 ISHIISQESGKKETFGTLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGSQIN 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INkihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00153 332 YS---PSLLWALGFVFLFTIGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFTGLTMNPKWL 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00153 409 KIQFFIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTSWNVISSIGSTISLISILFFIFIIWESMISKRPVLFSLNLSS 488

                        490       500
                 ....*....|....*....|.
gi 544583314 481 NLEWhYPIFPPQEHTFNETPL 501
Cdd:MTH00153 489 SIEW-LQNLPPAEHSYSELPL 508
Cyt_c_Oxidase_I cd01663
Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 1-484 0e+00

Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, may play a role in assembly or oxygen delivery to the active site. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme (heme a3) and a copper ion (CuB). It also contains a low-spin heme (heme a), believed to participate in the transfer of electrons to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from cytochrome c on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are transferred from cytochrome c (the electron donor) to heme a via the CuA binuclear site in subunit II, and directly from heme a to the binuclear center.


Pssm-ID: 238833  Cd Length: 488  Bit Score: 799.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:cd01663    5 DIGTLYLIFGLWSGLVGTSLSLLIRLELSQPGSQLGNDQLYNVIVTAHALIMIFFMVMPALIGGFGNWLVPLMIGAPDMA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:cd01663   85 FPRLNNLSFWLLPPSLLLLLLSALVEGGAGTGWTVYPPLSSILAHSGPSVDLAIFSLHLAGISSILGAINFITTIFNMRA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:cd01663  165 PGMTLEKMPLFVWSVLITAFLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGI 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:cd01663  245 ISHIISTFSGKKPVFGYLGMVYAMLSIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKVFSWLATMWGGSI- 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:cd01663  324 --KFETPMLWALGFIFLFTIGGLTGVVLANSSLDIALHDTYYVVAHFHYVLSMGAVFAIFAGFYYWFPKITGLSYNETLG 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNT-NNNYFNNEIS 479
Cdd:cd01663  402 KIHFWLMFIGVNLTFFPQHFLGLAGMPRRYPDYPDAYAGWNMISSIGSLISFVSVLLFLFIVWESFVSGrKVIFNVGEGS 481


                 ....*
gi 544583314 480 NNLEW 484
Cdd:cd01663  482 TSLEW 486
CtaD_CoxA TIGR02891
cytochrome c oxidase, subunit I; This large family represents subunit I's (CtaD, CoxA, CaaA) ...
 1-496 0e+00

cytochrome c oxidase, subunit I; This large family represents subunit I's (CtaD, CoxA, CaaA) of cytochrome c oxidases of bacterial origin. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits I-III form the functional core of the enzyme complex. Subunit I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit II and heme a of subunit I to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. In the bacilli an apparent split (paralogism) has created a sister clade (TIGR02882) encoding subunits (QoxA) of the aa3-type quinone oxidase complex which reacts directly with quinones, bypassing the interaction with soluble cytochrome c. This model attempts to exclude these sequences, placing them between the trusted and noise cutoffs. These families, as well as archaeal and eukaryotic cytochrome c subunit I's are included within the superfamily model, pfam00115. [Energy metabolism, Electron transport]


Pssm-ID: 213748  Cd Length: 499  Bit Score: 517.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314    1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMiGGFGNWLVPLMIGAPDMA 80
Cdd:TIGR02891   8 RIGILYLVTAFAFFLVGGVLALLMRAQLATPGNTFMDAETYNQLFTMHGTIMIFLFAIPIL-AGFGNYLLPLMIGARDMA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:TIGR02891  87 FPRLNAFSYWLYLFGGLLLLASFFTGGAPDTGWTMYPPLSSTSGSPGVGVDLWLLGLHLLGISSILGAVNFIVTILNMRA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:TIGR02891 167 PGMTLMRMPLFVWGILVTSILILLAFPVLIAALILLLLDRLFGTHFFDPARGGDPLLWQHLFWFFGHPEVYIIFLPAFGI 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  241 ISHVVTNRTGKNqPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:TIGR02891 247 ISEILPTFARKP-IFGYRAMVYATVAIGFLSFGVWAHHMFTTGMPPLALAFFSAATMLIAVPTGVKVFNWIATLWGGSIR 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  321 inkIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:TIGR02891 326 ---FTTPMLFALGFIFLFVIGGLTGVMLASVPLDWQLHDTYFVVAHFHYVLVGGSVFAIFAAIYYWFPKVTGRMYNERLG 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDA--FTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEI 478
Cdd:TIGR02891 403 RWHFWLTFVGFNLTFFPMHLLGLLGMPRRYYTYPPQmgFATLNLISTIGAFILAAGFLVFLWNLIWSLRKGPKAGANPWG 482

                         490
                  ....*....|....*...
gi 544583314  479 SNNLEWHYPIfPPQEHTF 496
Cdd:TIGR02891 483 ATTLEWTTSS-PPPAHNF 499
CyoB COG0843
Heme/copper-type cytochrome/quinol oxidase, subunit 1 [Energy production and conversion];
1-501 1.41e-179

Heme/copper-type cytochrome/quinol oxidase, subunit 1 [Energy production and conversion];


Pssm-ID: 440605  Cd Length: 535  Bit Score: 514.68  E-value: 1.41e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPiMIGGFGNWLVPLMIGAPDMA 80
Cdd:COG0843   17 RIGIMYLVTAFVFLLIGGLLALLMRLQLAGPGLGLLSPETYNQLFTMHGTIMIFFFATP-FLAGFGNYLVPLQIGARDMA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:COG0843   96 FPRLNALSFWLYLFGGLLLLISLFVGGAADVGWTFYPPLSGLEASPGVGVDLWLLGLALFGVGSILGGVNFIVTILKMRA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:COG0843  176 PGMTLMRMPLFTWAALVTSILILLAFPVLAAALLLLLLDRSLGTHFFDPAGGGDPLLWQHLFWFFGHPEVYILILPAFGI 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNqPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:COG0843  256 VSEIIPTFSRKP-LFGYKAMVLATVAIAFLSFLVWAHHMFTPGISPLVKAFFSIATMLIAVPTGVKVFNWIATMWRGRIR 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INkihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:COG0843  335 FT---TPMLFALGFIILFVIGGLTGVMLASVPLDYQVHDTYFVVAHFHYVLIGGVVFAFFAGLYYWFPKMTGRMLNERLG 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYP--DAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEI 478
Cdd:COG0843  412 KIHFWLWFIGFNLTFFPMHILGLLGMPRRYATYPpePGWQPLNLISTIGAFILAVGFLLFLINLVVSLRKGPKAGGNPWG 491

                        490       500
                 ....*....|....*....|...
gi 544583314 479 SNNLEWHYPIfPPQEHTFNETPL 501
Cdd:COG0843  492 ARTLEWATPS-PPPLYNFASIPV 513
COX1 pfam00115
Cytochrome C and Quinol oxidase polypeptide I; Cytochrome c oxidase (E.C:7.1.1.9) is a key ...
 1-441 2.62e-128

Cytochrome C and Quinol oxidase polypeptide I; Cytochrome c oxidase (E.C:7.1.1.9) is a key enzyme in aerobic metabolism. Proton pumping haem-copper oxidases represent the terminal, energy-transfer enzymes of respiratory chains in prokaryotes and eukaryotes. The CuB-haem a3 (or haem o) binuclear centre, associated with the largest subunit I of cytochrome c and ubiquinol oxidases (E.C:1.10.3.11), is directly involved in the coupling between dioxygen reduction and proton pumping. Some terminal oxidases generate a transmembrane proton gradient across the plasma membrane (prokaryotes) or the mitochondrial inner membrane (eukaryotes). The enzyme complex consists of 3-4 subunits (prokaryotes) up to 13 polypeptides (mammals) of which only the catalytic subunit (equivalent to mammalian subunit I (COXI) is found in all haem-copper respiratory oxidases. The presence of a bimetallic centre (formed by a high-spin haem and copper B) as well as a low-spin haem, both ligated to six conserved histidine residues near the outer side of four transmembrane spans within CO I is common to all family members.


Pssm-ID: 459678  Cd Length: 432  Bit Score: 379.99  E-value: 2.62e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314    1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPiMIGGFGNWLVPLMIGAPDMA 80
Cdd:pfam00115   1 RIGLLYLVTALVWFLVGGLLGLLIRLQLAFPGLNFLSPLTYNQLRTLHGNLMIFWFATP-FLFGFGNYLVPLMIGARDMA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   81 FPRMNNMSFWLIPPSFLLLLASAGnesGVGTGWTLYPPLSGptahaggcVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:pfam00115  80 FPRLNALSFWLVVLGAVLLLASFG---GATTGWTEYPPLVG--------VDLWYIGLLLAGVSSLLGAINFIVTILKRRA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  161 PGMSLdRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTtffdptGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:pfam00115 149 PGMTL-RMPLFVWAILATAILILLAFPVLAAALLLLLLDRSLGA------GGGDPLLDQHLFWWFGHPEVYILILPAFGI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  241 ISHVVTNRTGKnQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:pfam00115 222 IYYILPKFAGR-PLFGYKLSVLAFWLIAFLGFLVWAHHLFTTGLPPWLQALFSVFSMLIAVPSGVKVFNWLATLWGGWIR 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  321 INKihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:pfam00115 301 FRT--TPMLFFLGFAFLFIIGGLTGVMLALPPVNYYVHDTYFVVAHFHYVLFGGVVFALFGGIYYWLPKLTGRMYSEKLG 378

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 544583314  401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYS----DYPDAFTFWN 441
Cdd:pfam00115 379 KLHFWLLFIGFNLTFFPMHILGLLGMPRRYAppfiETVPAFQPLN 423
 
Name Accession Description Interval E-value
COX1 MTH00153
cytochrome c oxidase subunit I; Provisional
 1-501 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177210  Cd Length: 511  Bit Score: 845.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00153  12 DIGTLYFIFGAWSGMVGTSLSLLIRAELGQPGSLIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00153  92 FPRMNNMSFWLLPPSLTLLLSSSMVESGAGTGWTVYPPLSSNIAHSGASVDLAIFSLHLAGISSILGAINFITTIINMRS 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00153 172 KGMTLDRMPLFVWSVLITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGM 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:MTH00153 252 ISHIISQESGKKETFGTLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGSQIN 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INkihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00153 332 YS---PSLLWALGFVFLFTIGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFTGLTMNPKWL 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00153 409 KIQFFIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTSWNVISSIGSTISLISILFFIFIIWESMISKRPVLFSLNLSS 488

                        490       500
                 ....*....|....*....|.
gi 544583314 481 NLEWhYPIFPPQEHTFNETPL 501
Cdd:MTH00153 489 SIEW-LQNLPPAEHSYSELPL 508
COX1 MTH00037
cytochrome c oxidase subunit I; Provisional
 1-503 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177112  Cd Length: 517  Bit Score: 817.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00037  14 DIGTLYLIFGAWAGMVGTAMSVIIRTELAQPGSLLQDDQIYNVIVTAHALVMIFFMVMPIMIGGFGNWLIPLMIGAPDMA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00037  94 FPRMNNMSFWLIPPSFLLLLASAGVESGAGTGWTIYPPLSSNIAHAGGSVDLAIFSLHLAGASSILASINFITTIINMRT 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00037 174 PGMTFDRLPLFVWSVFITAFLLLLSLPVLAGAITMLLTDRNINTTFFDPAGGGDPILFQHLFWFFGHPEVYILILPGFGM 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:MTH00037 254 ISHVIAHYSGKQEPFGYLGMVYAMIAIGILGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWMATLQGSNLR 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INkihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00037 334 WE---TPLLWALGFVFLFTIGGLTGIVLANSSIDVVLHDTYYVVAHFHYVLSMGAVFAIFAGFTHWFPLFSGVSLHPLWS 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00037 411 KVHFFLMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSTISLVATLFFLFLIWEAFASQREVISPEFSSS 490

                        490       500
                 ....*....|....*....|...
gi 544583314 481 NLEWHYPIFPPQEHTFNETPLSI 503
Cdd:MTH00037 491 SLEWQYSSFPPSHHTFDETPSTV 513
Cyt_c_Oxidase_I cd01663
Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 1-484 0e+00

Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, may play a role in assembly or oxygen delivery to the active site. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme (heme a3) and a copper ion (CuB). It also contains a low-spin heme (heme a), believed to participate in the transfer of electrons to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from cytochrome c on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are transferred from cytochrome c (the electron donor) to heme a via the CuA binuclear site in subunit II, and directly from heme a to the binuclear center.


Pssm-ID: 238833  Cd Length: 488  Bit Score: 799.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:cd01663    5 DIGTLYLIFGLWSGLVGTSLSLLIRLELSQPGSQLGNDQLYNVIVTAHALIMIFFMVMPALIGGFGNWLVPLMIGAPDMA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:cd01663   85 FPRLNNLSFWLLPPSLLLLLLSALVEGGAGTGWTVYPPLSSILAHSGPSVDLAIFSLHLAGISSILGAINFITTIFNMRA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:cd01663  165 PGMTLEKMPLFVWSVLITAFLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGI 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:cd01663  245 ISHIISTFSGKKPVFGYLGMVYAMLSIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKVFSWLATMWGGSI- 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:cd01663  324 --KFETPMLWALGFIFLFTIGGLTGVVLANSSLDIALHDTYYVVAHFHYVLSMGAVFAIFAGFYYWFPKITGLSYNETLG 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNT-NNNYFNNEIS 479
Cdd:cd01663  402 KIHFWLMFIGVNLTFFPQHFLGLAGMPRRYPDYPDAYAGWNMISSIGSLISFVSVLLFLFIVWESFVSGrKVIFNVGEGS 481


                 ....*
gi 544583314 480 NNLEW 484
Cdd:cd01663  482 TSLEW 486
COX1 MTH00167
cytochrome c oxidase subunit I; Provisional
 1-501 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177222  Cd Length: 512  Bit Score: 778.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00167  14 DIGTLYFIFGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00167  94 FPRMNNMSFWLLPPSLLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGSINFITTIINMKP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00167 174 PGITQYQTPLFVWSILVTTILLLLSLPVLAAAITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGM 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00167 254 ISHIVVYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKVFSWLATLHGGKI- 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00167 333 --KWETPMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFTHWFPLFTGLTLNETWT 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00167 411 KIHFFVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNVVSSIGSLISLVAVILFLFIIWEAFSSKRKLLPVELTST 490

                        490       500
                 ....*....|....*....|.
gi 544583314 481 NLEWhYPIFPPQEHTFNETPL 501
Cdd:MTH00167 491 NVEW-LHGCPPPHHTWEEPPF 510
COX1 MTH00223
cytochrome c oxidase subunit I; Provisional
 1-504 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177260  Cd Length: 512  Bit Score: 759.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00223  11 DIGTLYLIFGMWSGLVGTSLSLLIRAELGQPGALLGDDQLYNVIVTAHAFVMIFFLVMPMMIGGFGNWLVPLMLGAPDMA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00223  91 FPRLNNMSFWLLPPSLYLLLSSSAVESGVGTGWTVYPPLSSNLAHAGPSVDLAIFSLHLAGVSSILGAINFITTIINMRS 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00223 171 PGMQLERLPLFVWSVKVTAFLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGM 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00223 251 ISHIVSHYSSKKEVFGTLGMIYAMLSIGVLGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWLATIYGSKI- 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00223 330 --KYEAPMLWALGFIFLFTVGGLTGIILSNSSLDIMLHDTYYVVAHFHYVLSMGAVFALFAGFNHWFPLFTGVTLHRRWA 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00223 408 KAHFFLMFLGVNLTFFPQHFLGLAGMPRRYSDYPDCYTKWNQVSSFGSMISFVSVLFFMFIVWEAFVSQRSVVWSGHLST 487

                        490       500
                 ....*....|....*....|....
gi 544583314 481 NLEWHYpIFPPQEHTFNETPLSIT 504
Cdd:MTH00223 488 SLEWDN-LLPADFHNNSETGALVI 510
COX1 MTH00116
cytochrome c oxidase subunit I; Provisional
 1-504 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177177  Cd Length: 515  Bit Score: 755.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00116  14 DIGTLYLIFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00116  94 FPRMNNMSFWLLPPSFLLLLASSTVEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGAINFITTCINMKP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00116 174 PAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGI 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00116 254 ISHIVTYYAGKKEPFGYMGMVWAMLSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGIKVFSWLATLHGGTI- 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00116 333 --KWDPPMLWALGFIFLFTIGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFTHWFPLFTGYTLHQTWT 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00116 411 KAQFGVMFTGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTISSIGSLISMTAVIMLMFIIWEAFSSKRKVLQPELTTT 490

                        490       500
                 ....*....|....*....|....
gi 544583314 481 NLEWHYPIfPPQEHTFNETPLSIT 504
Cdd:MTH00116 491 NIEWIHGC-PPPYHTFEEPAFVQV 513
COX1 MTH00142
cytochrome c oxidase subunit I; Provisional
 1-503 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 214431  Cd Length: 511  Bit Score: 733.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00142  12 DIGTLYFLFGAWAGMVGTGLSLLIRAELGQPGSLLGDDQLYNVIVTAHAFVMIFFMVMPVMIGGFGNWLVPLMLGAPDMA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00142  92 FPRMNNMSFWLLPPALLLLLSSAAVESGAGTGWTVYPPLSSNLAHSGGSVDLAIFSLHLAGVSSILGAINFITTVINMRA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00142 172 GGMKFERVPLFVWSVKITAILLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGM 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00142 252 ISHIINHYSGKKEVFGTLGMIYAMLSIGLLGFIVWAHHMFTVGMDVDTRAYFTAATMVIAVPTGIKVFSWLATLHGSKV- 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00142 331 --KYEPPMLWALGFIFLFTVGGLTGIVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFALFAGFIHWFPLFTGLTLNPRWL 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00142 409 KAHFYTMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNVVSSLGSMISFIAVLMFVFIVWESFVSQRLVMWSSHLST 488

                        490       500
                 ....*....|....*....|...
gi 544583314 481 NLEWHYpIFPPQEHTFNETPLSI 503
Cdd:MTH00142 489 SLEWSH-RLPPDFHTYDELPILV 510
COX1 MTH00183
cytochrome c oxidase subunit I; Provisional
 1-501 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177234  Cd Length: 516  Bit Score: 683.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00183  14 DIGTLYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00183  94 FPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00183 174 PAISQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGM 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00183 254 ISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSI- 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00183 333 --KWETPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAAFVHWFPLFSGYTLHSTWT 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00183 411 KIHFGVMFVGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSLISLVAVIMFLFILWEAFAAKREVLSVELTST 490

                        490       500
                 ....*....|....*....|.
gi 544583314 481 NLEWHYPIfPPQEHTFNETPL 501
Cdd:MTH00183 491 NVEWLHGC-PPPYHTFEEPAF 510
COX1 MTH00103
cytochrome c oxidase subunit I; Validated
 1-500 0e+00

cytochrome c oxidase subunit I; Validated


Pssm-ID: 177165  Cd Length: 513  Bit Score: 683.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00103  14 DIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00103  94 FPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00103 174 PAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGM 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00103 254 ISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNI- 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00103 333 --KWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWA 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00103 411 KIHFTIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVMLMIFMIWEAFASKREVLTVELTTT 490

                        490       500
                 ....*....|....*....|
gi 544583314 481 NLEWHYPIfPPQEHTFNETP 500
Cdd:MTH00103 491 NLEWLHGC-PPPYHTFEEPT 509
COX1 MTH00077
cytochrome c oxidase subunit I; Provisional
 1-504 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 214419  Cd Length: 514  Bit Score: 679.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00077  14 DIGTLYLVFGAWAGMVGTALSLLIRAELSQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00077  94 FPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTSINMKP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00077 174 PSMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPVLYQHLFWFFGHPEVYILILPGFGM 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGtslT 320
Cdd:MTH00077 254 ISHIVTYYSAKKEPFGYMGMVWAMMSIGLLGFIVWAHHMFTVDLNVDTRAYFTSATMIIAIPTGVKVFSWLATMHG---G 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00077 331 AIKWDAAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLHSTWS 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00077 411 KIHFGVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTVSSIGSLISLVAVIMMMFIIWEAFSSKREVLTTELTST 490

                        490       500
                 ....*....|....*....|....
gi 544583314 481 NLEWHYPiFPPQEHTFNETPLSIT 504
Cdd:MTH00077 491 NIEWLHG-CPPPYHTFEEPSFVQT 513
COX1 MTH00007
cytochrome c oxidase subunit I; Validated
 1-499 0e+00

cytochrome c oxidase subunit I; Validated


Pssm-ID: 133649  Cd Length: 511  Bit Score: 666.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00007  11 DIGTLYFILGVWGGLLGTSMSLLIRIELGQPGAFLGSDQLYNTIVTAHAFLMIFFLVMPVFIGGFGNWLVPLMLGAPDMA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00007  91 FPRLNNMSFWLLPPALILLVSSAAVEKGVGTGWTVYPPLASNLAHAGPSVDLAIFSLHLAGVSSILGAINFITTVINMRW 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00007 171 KGLRLERIPLFVWAVVITVVLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGA 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00007 251 ISHIVTHYAGKLEPFGTLGMIYAMLGIGVLGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWLATIHGSPI- 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00007 330 --KYETPMLWALGFIFLFTTGGLTGIVLSNSSLDIILHDTYYVVAHFHYVLSMGAVFAIFAAFNHWFPLFTGLTLHDRWA 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00007 408 KAHFFLMFLGVNLTFFPQHFLGLSGMPRRYSDYPDAYTKWNVVSSFGSMLSFVALLLFIFILWEAFSAQRGVIASPHMSS 487

                        490
                 ....*....|....*....
gi 544583314 481 NLEWHYPiFPPQEHTFNET 499
Cdd:MTH00007 488 SLEWQDT-LPLDFHNLPET 505
COX1 MTH00182
cytochrome c oxidase subunit I; Provisional
 1-501 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 214451  Cd Length: 525  Bit Score: 636.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00182  16 DIGTLYLVFGAGAGMIGTAFSMLIRLELSAPGAMLGDDHLYNVIVTAHAFIMIFFLVMPVMIGGFGNWLVPLYIGAPDMA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00182  96 FPRLNNISFWLLPPALILLLGSAFVEQGAGTGWTVYPPLSSIQAHSGGAVDMAIFSLHLAGVSSILGAINFITTIFNMRA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00182 176 PGVTFNRLPLFVWSILITAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILFQHLFWFFGHPEVYILILPGFGM 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00182 256 ISQIIPTFVAKKQIFGYLGMVYAMLSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWLATIYGGTL- 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00182 335 --RLDTPMLWAMGFVFLFTLGGLTGVVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWFGKITGYCYNELYG 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEIS- 479
Cdd:MTH00182 413 KIHFWLMFIGVNLTFFPQHFLGLAGFPRRYSDFADAFAGWNLVSSLGSIISIVGVVWFIYIIYDAYVREEKFIGWKEGTg 492

                        490       500
                 ....*....|....*....|....*
gi 544583314 480 ---NNLEWHYPIfPPQEHTFNETPL 501
Cdd:MTH00182 493 eswASLEWVHSS-PPLFHTYNELPF 516
COX1 MTH00184
cytochrome c oxidase subunit I; Provisional
 1-501 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177235  Cd Length: 519  Bit Score: 628.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00184  16 DIGTLYLLFGAFAGMIGTAFSMLIRLELSAPGSMLGDDHLYNVIVTAHAFVMIFFLVMPVMIGGFGNWFVPLYIGAPDMA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00184  96 FPRLNNISFWLLPPALTLLLGSAFVEQGAGTGWTVYPPLSSIQAHSGGSVDMAIFSLHLAGISSILGAMNFITTIFNMRA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00184 176 PGITMDRMPLFVWSILVTTFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGI 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00184 256 ISQIIPTFAAKKQIFGYLGMVYAMVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWIATIFGGSL- 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00184 335 --RLDTPMLWAIGFVFLFTMGGLTGIVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWFGKITGYCYNEVYG 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00184 413 KIHFWLMFIGVNLTFFPQHFLGLAGLPRRYSDFHDSFAGWNQISSLGSVISIVGVVWFIYIVYDAYVREIKFVGWVEDSG 492

                        490       500
                 ....*....|....*....|....
gi 544583314 481 ---NLEWHYPIfPPQEHTFNETPL 501
Cdd:MTH00184 493 hypSLEWAQTS-PPAHHTYNELPY 515
COX1 MTH00079
cytochrome c oxidase subunit I; Provisional
 1-490 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177148  Cd Length: 508  Bit Score: 617.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00079  15 DIGTLYFLFGLWSGMVGTSLSLIIRLELSKPGLLLGNGQLYNSVITAHAILMIFFMVMPSMIGGFGNWMLPLMLGAPDMS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGpTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00079  95 FPRLNNLSFWLLPTSLFLILDSCFVDMGPGTSWTVYPPLST-LGHPGSSVDLAIFSLHCAGISSILGGINFMVTTKNLRS 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00079 174 SSISLEHMSLFVWTVFVTVFLLVLSLPVLAGAITMLLTDRNLNTSFFDPSTGGNPLLYQHLFWFFGHPEVYILILPAFGI 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLt 320
Cdd:MTH00079 254 ISQSTLYLTGKKEVFGSLGMVYAILSIGLIGCVVWAHHMYTVGMDLDSRAYFTAATMVIAVPTGVKVFSWLATLFGMKM- 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 inKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00079 333 --KFQPLLLWVLGFIFLFTIGGLTGVILSNSSLDIILHDTYYVVSHFHYVLSLGAVFGIFTGISLWWPFMTGIVYDKLMM 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEISN 480
Cdd:MTH00079 411 SAVFFLMFVGVNLTFFPLHFAGLHGMPRKYLDYPDVYSVWNVISSYGSMISVFALFLFIYVLLESFFSYRLVLHDNYINS 490

                        490
                 ....*....|
gi 544583314 481 NLEWHYPIFP 490
Cdd:MTH00079 491 SPEYSLSSYV 500
COX1 MTH00026
cytochrome c oxidase subunit I; Provisional
 1-500 0e+00

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 164599  Cd Length: 534  Bit Score: 560.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMA 80
Cdd:MTH00026  15 DIGSLYLVFGALSGAIGTAFSMLIRLELSSPGSMLGDDHLYNVIVTAHAFVMIFFLVMPTMIGGFGNWFVPLMIGAPDMA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:MTH00026  95 FPRLNNISFWLLPPALFLLLGSSLVEQGAGTGWTVYPPLASIQAHSGGSVDMAIFSLHLAGLSSILGAMNFITTVMNMRT 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:MTH00026 175 PGMTMSRIPLFVWSVFITAILLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGI 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:MTH00026 255 ISQILSLFSYKKQIFGYLGMVYAMLAIGVLGFIVWAHHMYVVGMDVDTRAYFTAATMIIAVPTGIKIFSWLATVSGSGRN 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INKIHPsLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:MTH00026 335 LIFTTP-MAWALGFIFLFTIGGLTGIVLSNSSLDILLHDTYYVVAHFHFVLSMGAVFAIFGGFYLWFGKITGYAYKDIYG 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIV-------------ILSLN 467
Cdd:MTH00026 414 LIHFWLMFIGVNITFFPQHFLGLAGLPRRYADYPDNFEDFNQISSFGSIISIIAVIWFIVVIfdayyreepfdinIMAKG 493

                        490       500       510
                 ....*....|....*....|....*....|...
gi 544583314 468 NTNNNYFNNEISNNLEWHYpIFPPQEHTFNETP 500
Cdd:MTH00026 494 PLIPFSCQPAHFDTLEWSL-TSPPEHHTYNELP 525
Heme_Cu_Oxidase_I cd00919
Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in ...
 1-466 0e+00

Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is diverse in terms of electron donors, subunit composition, and heme types. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. It has been proposed that Archaea acquired heme-copper oxidases through gene transfer from Gram-positive bacteria. Membership in the superfamily is defined by subunit I, which contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme and a copper ion. It also contains a low-spin heme, believed to participate in the transfer of electrons to the binuclear center. Only subunit I is common to the entire superfamily. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from the electron donor on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I of cytochrome c oxidase (CcO) and ubiquinol oxidase. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electron transfer occurs in two segments: from the electron donor to the low-spin heme, and from the low-spin heme to the binuclear center. The first segment can be a multi-step process and varies among the different families, while the second segment, a direct transfer, is consistent throughout the superfamily.


Pssm-ID: 238461  Cd Length: 463  Bit Score: 551.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPlMIGAPDMA 80
Cdd:cd00919    3 DIGLLYLIFAFVALLLGGLLALLIRLELATPGSLFLDPQLYNQLVTAHGVIMIFFFVMPAIFGGFGNLLPP-LIGARDLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:cd00919   82 FPRLNNLSFWLFPPGLLLLLSSVLVGGGAGTGWTFYPPLSTLSYSSGVGVDLAILGLHLAGVSSILGAINFITTILNMRA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:cd00919  162 PGMTLDKMPLFVWSVLVTAILLLLALPVLAAALVMLLLDRNFGTSFFDPAGGGDPVLYQHLFWFFGHPEVYILILPAFGA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNqPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:cd00919  242 ISEIIPTFSGKP-LFGYKLMVYAFLAIGFLSFLVWAHHMFTVGLPVDTRAYFTAATMIIAVPTGIKVFNWLATLWGGRIR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INkihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:cd00919  321 FD---PPMLFALGFLFLFTIGGLTGVVLANVPLDIVLHDTYYVVAHFHYVLSGGVVFAIFAGLYYWFPKMTGRMLSEKLG 397

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSL 466
Cdd:cd00919  398 KIHFWLWFIGFNLTFFPMHFLGLLGMPRRYADYPDGFAPWNFISSVGAFILGLGLLLFLGNLFLSL 463
CtaD_CoxA TIGR02891
cytochrome c oxidase, subunit I; This large family represents subunit I's (CtaD, CoxA, CaaA) ...
 1-496 0e+00

cytochrome c oxidase, subunit I; This large family represents subunit I's (CtaD, CoxA, CaaA) of cytochrome c oxidases of bacterial origin. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits I-III form the functional core of the enzyme complex. Subunit I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit II and heme a of subunit I to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. In the bacilli an apparent split (paralogism) has created a sister clade (TIGR02882) encoding subunits (QoxA) of the aa3-type quinone oxidase complex which reacts directly with quinones, bypassing the interaction with soluble cytochrome c. This model attempts to exclude these sequences, placing them between the trusted and noise cutoffs. These families, as well as archaeal and eukaryotic cytochrome c subunit I's are included within the superfamily model, pfam00115. [Energy metabolism, Electron transport]


Pssm-ID: 213748  Cd Length: 499  Bit Score: 517.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314    1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMiGGFGNWLVPLMIGAPDMA 80
Cdd:TIGR02891   8 RIGILYLVTAFAFFLVGGVLALLMRAQLATPGNTFMDAETYNQLFTMHGTIMIFLFAIPIL-AGFGNYLLPLMIGARDMA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:TIGR02891  87 FPRLNAFSYWLYLFGGLLLLASFFTGGAPDTGWTMYPPLSSTSGSPGVGVDLWLLGLHLLGISSILGAVNFIVTILNMRA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:TIGR02891 167 PGMTLMRMPLFVWGILVTSILILLAFPVLIAALILLLLDRLFGTHFFDPARGGDPLLWQHLFWFFGHPEVYIIFLPAFGI 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  241 ISHVVTNRTGKNqPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:TIGR02891 247 ISEILPTFARKP-IFGYRAMVYATVAIGFLSFGVWAHHMFTTGMPPLALAFFSAATMLIAVPTGVKVFNWIATLWGGSIR 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  321 inkIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:TIGR02891 326 ---FTTPMLFALGFIFLFVIGGLTGVMLASVPLDWQLHDTYFVVAHFHYVLVGGSVFAIFAAIYYWFPKVTGRMYNERLG 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDA--FTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEI 478
Cdd:TIGR02891 403 RWHFWLTFVGFNLTFFPMHLLGLLGMPRRYYTYPPQmgFATLNLISTIGAFILAAGFLVFLWNLIWSLRKGPKAGANPWG 482

                         490
                  ....*....|....*...
gi 544583314  479 SNNLEWHYPIfPPQEHTF 496
Cdd:TIGR02891 483 ATTLEWTTSS-PPPAHNF 499
CyoB COG0843
Heme/copper-type cytochrome/quinol oxidase, subunit 1 [Energy production and conversion];
1-501 1.41e-179

Heme/copper-type cytochrome/quinol oxidase, subunit 1 [Energy production and conversion];


Pssm-ID: 440605  Cd Length: 535  Bit Score: 514.68  E-value: 1.41e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPiMIGGFGNWLVPLMIGAPDMA 80
Cdd:COG0843   17 RIGIMYLVTAFVFLLIGGLLALLMRLQLAGPGLGLLSPETYNQLFTMHGTIMIFFFATP-FLAGFGNYLVPLQIGARDMA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  81 FPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:COG0843   96 FPRLNALSFWLYLFGGLLLLISLFVGGAADVGWTFYPPLSGLEASPGVGVDLWLLGLALFGVGSILGGVNFIVTILKMRA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 161 PGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:COG0843  176 PGMTLMRMPLFTWAALVTSILILLAFPVLAAALLLLLLDRSLGTHFFDPAGGGDPLLWQHLFWFFGHPEVYILILPAFGI 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 241 ISHVVTNRTGKNqPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:COG0843  256 VSEIIPTFSRKP-LFGYKAMVLATVAIAFLSFLVWAHHMFTPGISPLVKAFFSIATMLIAVPTGVKVFNWIATMWRGRIR 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 321 INkihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:COG0843  335 FT---TPMLFALGFIILFVIGGLTGVMLASVPLDYQVHDTYFVVAHFHYVLIGGVVFAFFAGLYYWFPKMTGRMLNERLG 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYP--DAFTFWNTLSSLGSLLSFIGTIGFLTIVILSLNNTNNNYFNNEI 478
Cdd:COG0843  412 KIHFWLWFIGFNLTFFPMHILGLLGMPRRYATYPpePGWQPLNLISTIGAFILAVGFLLFLINLVVSLRKGPKAGGNPWG 491

                        490       500
                 ....*....|....*....|...
gi 544583314 479 SNNLEWHYPIfPPQEHTFNETPL 501
Cdd:COG0843  492 ARTLEWATPS-PPPLYNFASIPV 513
COX1 MTH00048
cytochrome c oxidase subunit I; Provisional
 2-442 3.12e-161

cytochrome c oxidase subunit I; Provisional


Pssm-ID: 177123  Cd Length: 511  Bit Score: 467.23  E-value: 3.12e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   2 IGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGGFGNWLVPLMIGAPDMAF 81
Cdd:MTH00048  16 IGVIYTLLGVWSGFVGLSLSLLIRLNFLDPYYNVISLDVYNFLITNHGIIMIFFFLMPVLIGGFGNYLLPLLLGLSDLNL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  82 PRMNNMSFWLIPPSFLLLLASAgnESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRAP 161
Cdd:MTH00048  96 PRLNALSAWLLVPSIVFLLLSM--CLGAGVGWTFYPPLSSSLFSSSWGVDFLMFSLHLAGVSSLFGSINFICTIYSAFMT 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 162 GMSLdRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGII 241
Cdd:MTH00048 174 NVFS-RTSIILWSYLFTSILLLLSLPVLAAAITMLLFDRNFGSAFFDPLGGGDPVLFQHMFWFFGHPEVYVLILPGFGII 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 242 SHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLti 321
Cdd:MTH00048 253 SHICLSLSNNDDPFGYYGLVFAMFSIVCLGSVVWAHHMFTVGLDVKTAVFFSSVTMIIGVPTGIKVFSWLYMLLNSRV-- 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 322 NKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGAT 401
Cdd:MTH00048 331 RKSDPVVWWVVSFIVLFTIGGVTGIVLSASVLDNVLHDTWFVVAHFHYVLSLGSYSSVVIMFIWWWPLITGLSLNKYLLQ 410

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 544583314 402 AHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAFTFWNT 442
Cdd:MTH00048 411 CHCIISMIGFNLCFFPMHYFGLCGLPRRVCVYEPSYYWINV 451
Ubiquinol_Oxidase_I cd01662
Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory ...
 2-463 1.72e-149

Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits in ubiquinol oxidase varies from two to five. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme and a copper ion. It also contains a low-spin heme, believed to participate in the transfer of electrons from ubiquinol to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from ubiquinol on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. It is generally believed that the channels contain water molecules that act as 'proton wires' to transfer the protons. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are believed to be transferred directly from ubiquinol (the electron donor) to the low-spin heme, and directly from the low-spin heme to the binuclear center.


Pssm-ID: 238832  Cd Length: 501  Bit Score: 436.63  E-value: 1.72e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   2 IGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPIMIGgFGNWLVPLMIGAPDMAF 81
Cdd:cd01662   10 IGIMYIITAFVFFLRGGVDALLMRTQLALPGNDFLSPEHYNQIFTMHGTIMIFLFAMPLVFG-LMNYLVPLQIGARDVAF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  82 PRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLSGPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRAP 161
Cdd:cd01662   89 PRLNALSFWLFLFGGLLLNASLLIGGFPDAGWFAYPPLSGLEYSPGVGVDYWILGLQFSGIGTLLGAINFIVTILKMRAP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 162 GMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGII 241
Cdd:cd01662  169 GMTLMRMPIFTWTTLVTSILILFAFPVLTAALALLELDRYFGTHFFTNALGGNPMLWQHLFWIFGHPEVYILILPAFGIF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 242 SHVVTNRTGKNQpFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLTi 321
Cdd:cd01662  249 SEIVPTFSRKPL-FGYRSMVYATVAIGFLSFGVWVHHMFTTGAGALVNAFFSIATMIIAVPTGVKIFNWLFTMWRGRIR- 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 322 nkIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGAT 401
Cdd:cd01662  327 --FETPMLWAIGFLVTFVIGGLTGVMLASPPADFQVHDTYFVVAHFHYVLIGGVVFPLFAGFYYWFPKMFGRMLNERLGK 404

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544583314 402 AHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAfTFWNTLSSLGSLLSFIGTIGFLTIVI 463
Cdd:cd01662  405 WSFWLWFIGFNLTFFPMHILGLMGMPRRVYTYLPG-PGWDPLNLISTIGAFLIAAGVLLFLI 465
COX1 pfam00115
Cytochrome C and Quinol oxidase polypeptide I; Cytochrome c oxidase (E.C:7.1.1.9) is a key ...
 1-441 2.62e-128

Cytochrome C and Quinol oxidase polypeptide I; Cytochrome c oxidase (E.C:7.1.1.9) is a key enzyme in aerobic metabolism. Proton pumping haem-copper oxidases represent the terminal, energy-transfer enzymes of respiratory chains in prokaryotes and eukaryotes. The CuB-haem a3 (or haem o) binuclear centre, associated with the largest subunit I of cytochrome c and ubiquinol oxidases (E.C:1.10.3.11), is directly involved in the coupling between dioxygen reduction and proton pumping. Some terminal oxidases generate a transmembrane proton gradient across the plasma membrane (prokaryotes) or the mitochondrial inner membrane (eukaryotes). The enzyme complex consists of 3-4 subunits (prokaryotes) up to 13 polypeptides (mammals) of which only the catalytic subunit (equivalent to mammalian subunit I (COXI) is found in all haem-copper respiratory oxidases. The presence of a bimetallic centre (formed by a high-spin haem and copper B) as well as a low-spin haem, both ligated to six conserved histidine residues near the outer side of four transmembrane spans within CO I is common to all family members.


Pssm-ID: 459678  Cd Length: 432  Bit Score: 379.99  E-value: 2.62e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314    1 DIGTLYLIFGAWAGTVGTAMSNIIRVELSQPGSLIQNDQIYNVMVTSHALIMIFFMVMPiMIGGFGNWLVPLMIGAPDMA 80
Cdd:pfam00115   1 RIGLLYLVTALVWFLVGGLLGLLIRLQLAFPGLNFLSPLTYNQLRTLHGNLMIFWFATP-FLFGFGNYLVPLMIGARDMA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314   81 FPRMNNMSFWLIPPSFLLLLASAGnesGVGTGWTLYPPLSGptahaggcVDLAIFSLHLAGASSIMASINFISTIINMRA 160
Cdd:pfam00115  80 FPRLNALSFWLVVLGAVLLLASFG---GATTGWTEYPPLVG--------VDLWYIGLLLAGVSSLLGAINFIVTILKRRA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  161 PGMSLdRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDRNINTtffdptGGGDPILFQHLFWFFGHPEVYILILPGFGI 240
Cdd:pfam00115 149 PGMTL-RMPLFVWAILATAILILLAFPVLAAALLLLLLDRSLGA------GGGDPLLDQHLFWWFGHPEVYILILPAFGI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  241 ISHVVTNRTGKnQPFGFLGMMYAMIAIGILGFIVWAHHMFTVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLT 320
Cdd:pfam00115 222 IYYILPKFAGR-PLFGYKLSVLAFWLIAFLGFLVWAHHLFTTGLPPWLQALFSVFSMLIAVPSGVKVFNWLATLWGGWIR 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  321 INKihPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDTYYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGA 400
Cdd:pfam00115 301 FRT--TPMLFFLGFAFLFIIGGLTGVMLALPPVNYYVHDTYFVVAHFHYVLFGGVVFALFGGIYYWLPKLTGRMYSEKLG 378

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 544583314  401 TAHFILMFIGVNLTFFPQHFLGLAGMPRRYS----DYPDAFTFWN 441
Cdd:pfam00115 379 KLHFWLLFIGFNLTFFPMHILGLLGMPRRYAppfiETVPAFQPLN 423
PRK15017 PRK15017
cytochrome o ubiquinol oxidase subunit I; Provisional
 41-435 6.72e-92

cytochrome o ubiquinol oxidase subunit I; Provisional


Pssm-ID: 184978  Cd Length: 663  Bit Score: 293.77  E-value: 6.72e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314  41 YNVMVTSHALIMIFFMVMPIMIGgFGNWLVPLMIGAPDMAFPRMNNMSFWLIPPSFLLLLASAGNESGVGTGWTLYPPLS 120
Cdd:PRK15017  99 YDQIFTAHGVIMIFFVAMPFVIG-LMNLVVPLQIGARDVAFPFLNNLSFWFTVVGVILVNVSLGVGEFAQTGWLAYPPLS 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 121 GPTAHAGGCVDLAIFSLHLAGASSIMASINFISTIINMRAPGMSLDRTPLFVWSILITTFLLLLSLPVLAGAITMLLTDR 200
Cdd:PRK15017 178 GIEYSPGVGVDYWIWSLQLSGIGTTLTGINFFVTILKMRAPGMTMFKMPVFTWASLCANVLIIASFPILTVTVALLTLDR 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 201 NINTTFFDPTGGGDPILFQHLFWFFGHPEVYILILPGFGIISHVVTNRTgKNQPFGFLGMMYAMIAIGILGFIVWAHHMF 280
Cdd:PRK15017 258 YLGTHFFTNDMGGNMMMYINLIWAWGHPEVYILILPVFGVFSEIAATFS-RKRLFGYTSLVWATVCITVLSFIVWLHHFF 336

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 281 TVGLDVDTRAYFTAATMIIAIPTGVKVFSWLATLQGTSLtinKIHPSLMWALGFIFLFTIGGLTGIILSNSSLNIALHDT 360
Cdd:PRK15017 337 TMGAGANVNAFFGITTMIIAIPTGVKIFNWLFTMYQGRI---VFHSAMLWTIGFIVTFSVGGMTGVLLAVPGADFVLHNS 413

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544583314 361 YYVTAHFHYVLSMGAVFAIFSGFNHWFSLFTGCHLDESGATAHFILMFIGVNLTFFPQHFLGLAGMPRRYSDYPD 435
Cdd:PRK15017 414 LFLIAHFHNVIIGGVVFGCFAGMTYWWPKAFGFKLNETWGKRAFWFWIIGFFVAFMPLYALGFMGMTRRLSQQID 488
ba3-like_Oxidase_I cd01660
ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are ...
 214-466 2.74e-14

ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the membrane. It has been proposed that Archaea acquired heme-copper oxidases through gene transfer from Gram-positive bacteria. The ba3 family contains oxidases that lack the conserved residues that form the D- and K-pathways in CcO and ubiquinol oxidase. Instead they contain a potential alternative K-pathway. Additional proton channels have been proposed for this family of oxidases but none have been identified definitively. For general information on the heme-copper oxidase superfamily, please see cd00919.


Pssm-ID: 238830  Cd Length: 473  Bit Score: 75.02  E-value: 2.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 214 DPILFQHLFWFFGHPEVYILILPGFgIISHVVTNRTGKNQPFGFLGMMYAMIAIGILGFIVWAHHMFT-VGLDVDTRAYF 292
Cdd:cd01660  200 DVLLSRTLFWWFGHPLVYFWLLPAY-IAWYTILPKIAGGKLFSDPLARLAFILFLLFSTPVGFHHQFAdPGIGPGWKFIH 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 293 TAATMIIAIPTGVKVFSWLATL------QGTSLTINKIHpSLMW--------ALGFIFlFTIGGLTGIILSNSSLNIALH 358
Cdd:cd01660  279 MVLTFMVALPSLLTAFTVFASLeiagrlRGGKGLFGWIR-ALPWgdpmflalFLAMLM-FIPGGAGGIINASYQLNYVVH 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583314 359 DTYYVTAHFHyvLSMGAVFAI-FSGFNHWF-SLFTGCHLDESG-ATAHFILMFIGVNLTFFPQHFLGLAGMPRR------ 429
Cdd:cd01660  357 NTAWVPGHFH--LTVGGAVALtFMAVAYWLvPHLTGRELAAKRlALAQPWLWFVGMTIMSTAMHVAGLLGAPRRtaeaqy 434

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 544583314 430 -YSDYPDAFTFWNTLSSLGSLLSFIGTIGFLTIVILSL 466
Cdd:cd01660  435 gGLPAAGEWAPYQQLMAIGGTILFVSGALFLYILFRTL 472
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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