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Conserved domains on  [gi|543583768|ref|NP_001269516|]
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GDH/6PGL endoplasmic bifunctional protein isoform 1 precursor [Homo sapiens]

Protein Classification

6-phosphogluconolactonase; glucosamine/galactosamine-6-phosphate isomerase/deaminase family protein( domain architecture ID 13232975)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway; glucosamine/galactosamine-6-phosphate isomerase/deaminase family protein similar to Escherichia coli protein YieK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 567-802 6.74e-99

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 306.22  E-value: 6.74e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  567 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 646
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  647 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 723
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  724 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 802
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 37-515 1.39e-98

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 316.69  E-value: 1.39e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  37 VSIILLGATGDLAKKYLWQGLFQLYLdEAGRGHSFSFHGAALTA-PKQGQ---ELMAKALESLSCPkdmapshcAEHKDQ 112
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYC-EGLLPSEVNIVGYARSKmSDVERwkkETLARFFKRLDDR--------ECHLEQ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 113 FLQLSQYR--QLKTAEDYQALNKDIEAQLQHAGLREAG--RIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVVLEKPFG 188
Cdd:PTZ00309 126 FLKHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 189 HDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEY 268
Cdd:PTZ00309 205 RDLESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSY 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 269 GVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQY-QSYSEQVRRELQKPD-SFHSLTP 346
Cdd:PTZ00309 284 GIIRDVMQNHLLQILALLAMEKPVSL-SAEDIRDEKVKVLKCIEPIKMEECVLGQYtASADGSIPGYLEDEGvPKDSTTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 347 TFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvQSEKHWAAAQSQclPRQLVFHIGhgdlGSPAVLVS 426
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----VDEFRPSGDDTQ--RNELVIRAQ----PSEAMYLK 431

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 427 RNLFRPSLPSSWKEMEgppgLRLfgsplsDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAH 506
Cdd:PTZ00309 432 ITAKVPGLSNDLHQTE----LDL------TYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDR 501

                        490
                 ....*....|.
gi 543583768 507 K--APRLYPGG 515
Cdd:PTZ00309 502 GevKPEPYPFG 512
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 567-802 6.74e-99

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 306.22  E-value: 6.74e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  567 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 646
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  647 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 723
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  724 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 802
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 37-515 1.39e-98

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 316.69  E-value: 1.39e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  37 VSIILLGATGDLAKKYLWQGLFQLYLdEAGRGHSFSFHGAALTA-PKQGQ---ELMAKALESLSCPkdmapshcAEHKDQ 112
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYC-EGLLPSEVNIVGYARSKmSDVERwkkETLARFFKRLDDR--------ECHLEQ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 113 FLQLSQYR--QLKTAEDYQALNKDIEAQLQHAGLREAG--RIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVVLEKPFG 188
Cdd:PTZ00309 126 FLKHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 189 HDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEY 268
Cdd:PTZ00309 205 RDLESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSY 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 269 GVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQY-QSYSEQVRRELQKPD-SFHSLTP 346
Cdd:PTZ00309 284 GIIRDVMQNHLLQILALLAMEKPVSL-SAEDIRDEKVKVLKCIEPIKMEECVLGQYtASADGSIPGYLEDEGvPKDSTTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 347 TFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvQSEKHWAAAQSQclPRQLVFHIGhgdlGSPAVLVS 426
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----VDEFRPSGDDTQ--RNELVIRAQ----PSEAMYLK 431

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 427 RNLFRPSLPSSWKEMEgppgLRLfgsplsDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAH 506
Cdd:PTZ00309 432 ITAKVPGLSNDLHQTE----LDL------TYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDR 501

                        490
                 ....*....|.
gi 543583768 507 K--APRLYPGG 515
Cdd:PTZ00309 502 GevKPEPYPFG 512
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 39-515 3.52e-88

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 287.29  E-value: 3.52e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768   39 IILLGATGDLAKKYLWQGLFQLYldEAGR-GHSFSFHGAALTaPKQGQELMAKALESLScpkDMAPSHCAEHKDQFLQLS 117
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLF--RNGLlPPDFRIVGVARR-DWSVEEFRKVVREAII---KFETDEIDEQWDEFAQRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  118 QYR--QLKTAEDYQALNKDIEaQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQ 195
Cdd:TIGR00871  79 SYVsgDVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  196 QLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVL 275
Cdd:TIGR00871 158 ELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  276 QNHLTEVLTLVAMELPhNVSSAEAVLRHKLQVFQALRGLQRG--SAVVGQY-----QSYSEQVRRELQKPDSfHSLTPTF 348
Cdd:TIGR00871 237 QNHLLQLLALVAMEPP-VSFDADSIRDEKVKVLKALRPIDPDdnNTVRGQYgageiGGVSVPGYLEEEGVDK-DSNTETF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  349 AAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccVQSEKHWAAAQSQCLPRQLVFHIGhgdlGSPAVLVSRN 428
Cdd:TIGR00871 315 AALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRD----VPSLLFKANERDANPRNALVIRIQ----PDEGVYLKFN 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  429 LFRPSLPSSWKEMEgppglrLFGSPLSDYYAYSPvrerDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLA-HK 507
Cdd:TIGR00871 387 AKKPGLNFETRPVK------LDFSYASRFGELLP----EAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAaNK 456

                         490
                  ....*....|
gi 543583768  508 APRL--YPGG 515
Cdd:TIGR00871 457 GPSPpnYPAG 466
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
569-793 2.57e-84

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 267.57  E-value: 2.57e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  569 AWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQ 648
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  649 AHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALVANSS---FDLVLLGMGADGHTASLFPQSPTGLDGEQ 725
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  726 LVV-LTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV-GHEPKKWPISGVLPHSGQLVW 793
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 572-795 1.00e-79

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 255.18  E-value: 1.00e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 572 EELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAhYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHL 651
Cdd:cd01400    1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 652 LQHVRIPYYNIHPMPVHLqqrlcaEEDQGAQIYAREISALVANS-SFDLVLLGMGADGHTASLFPQSP-TGLDGEQLVVL 729
Cdd:cd01400   80 LSHVAIPAANIHPIPTEL------GPEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 543583768 730 TT-SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSGQLVWYM 795
Cdd:cd01400  154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 39-377 3.57e-78

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 260.78  E-value: 3.57e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  39 IILLGATGDLAKKYLWQGLFQLYLDeaGR-GHSFSFHGAALTAPKQGQ--ELMAKALESLScPKDMAPSHCaehkDQFLQ 115
Cdd:COG0364   12 LVIFGATGDLARRKLLPALYNLYRD--GLlPEGFRIIGVARRDWSDEEfrEEVREALEEFS-RKPFDEEVW----ERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 116 LSQYRQL--KTAEDYQALNKDIEAQlqHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFS 193
Cdd:COG0364   85 RLHYVSGdfTDPEGYERLKELLEEL--DEERTPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLAS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 194 AQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRD 273
Cdd:COG0364  163 ARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 274 VLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRG----SAVVGQY---QSYSEQV---RRELQKPDsfHS 343
Cdd:COG0364  242 MVQNHLLQLLCLVAMEPPASL-DADAIRDEKVKVLRALRPITPEdvaeNTVRGQYtagWIGGEPVpgyREEPGVAP--DS 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 543583768 344 LTPTFAAVLVHIDNLRWEGVPFILMSGKALDERV 377
Cdd:COG0364  319 TTETFVALKLEIDNWRWAGVPFYLRTGKRLPERV 352
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
239-515 2.88e-67

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 225.01  E-value: 2.88e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  239 LWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPhnVS-SAEAVLRHKLQVFQALRGLQRG 317
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPP--VSfDAEDIRDEKVKVLRSLRPITPE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  318 S----AVVGQYQSYS---EQV---RRELQKPDsfHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQ 387
Cdd:pfam02781  91 DvednVVRGQYGAGWiggEPVpgyREEEGVPP--DSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFKDV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  388 ACCVQSEKHwaaaqsQCLPRQLVFHIGHGdlgsPAVLVSRNLFRPslpsswkemeGpPGLRLFGSPLS-DYYAYSPVRER 466
Cdd:pfam02781 169 PHNLFRDPG------TLPPNELVIRIQPD----EGIYLKFNAKVP----------G-LGMRLRPVELDfSYSDRFGERIP 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 543583768  467 DAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGG 515
Cdd:pfam02781 228 EAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 571-799 9.83e-56

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.91  E-value: 9.83e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 571 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESNFQGL 647
Cdd:COG0363   10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKegGLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 648 QAHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLV 727
Cdd:COG0363   90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 728 VLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSgQLVW 793
Cdd:COG0363  162 TLDEStrqanarffgsiPKVPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                 ....*.
gi 543583768 794 YMDYDA 799
Cdd:COG0363  238 FLDEAA 243
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 571-799 2.91e-29

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 117.65  E-value: 2.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 571 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSpVALFQQLATAHYG--FPWAHTHLWLVDERCVPLSDPESNFQGLQ 648
Cdd:PLN02360  19 LDELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYNktVDWAKWYIFWADERVVAKNHADSNYKLAK 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 649 AHLLQHVRIPYYNIHPmpvhLQQRLCAEEdqGAQIYAREISALVANSS-----------FDLVLLGMGADGHTASLFPQS 717
Cdd:PLN02360  98 DGLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNH 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 718 PT-GLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTL-VSRVGHEP--KKWPISGVLPHSGQLVW 793
Cdd:PLN02360 172 PAlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVW 251


                 ....*.
gi 543583768 794 YMDYDA 799
Cdd:PLN02360 252 FLDKPA 257
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 567-802 6.74e-99

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 306.22  E-value: 6.74e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  567 VSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHygFPWAHTHLWLVDERCVPLSDPESNFQG 646
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQP--LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  647 LQAHLLQHVRIPYYNIHPMPVHLQqrlcaEEDQGAQIYAREISALVAN---SSFDLVLLGMGADGHTASLFPQSPTGLDG 723
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELS-----DIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  724 EQLV-VLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLpHSGQLVWYMDYDAFLG 802
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARK 232
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 37-515 1.39e-98

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 316.69  E-value: 1.39e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  37 VSIILLGATGDLAKKYLWQGLFQLYLdEAGRGHSFSFHGAALTA-PKQGQ---ELMAKALESLSCPkdmapshcAEHKDQ 112
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYC-EGLLPSEVNIVGYARSKmSDVERwkkETLARFFKRLDDR--------ECHLEQ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 113 FLQLSQYR--QLKTAEDYQALNKDIEAQLQHAGLREAG--RIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVVLEKPFG 188
Cdd:PTZ00309 126 FLKHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 189 HDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEY 268
Cdd:PTZ00309 205 RDLESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSY 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 269 GVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQY-QSYSEQVRRELQKPD-SFHSLTP 346
Cdd:PTZ00309 284 GIIRDVMQNHLLQILALLAMEKPVSL-SAEDIRDEKVKVLKCIEPIKMEECVLGQYtASADGSIPGYLEDEGvPKDSTTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 347 TFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvQSEKHWAAAQSQclPRQLVFHIGhgdlGSPAVLVS 426
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----VDEFRPSGDDTQ--RNELVIRAQ----PSEAMYLK 431

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 427 RNLFRPSLPSSWKEMEgppgLRLfgsplsDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAH 506
Cdd:PTZ00309 432 ITAKVPGLSNDLHQTE----LDL------TYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDR 501

                        490
                 ....*....|.
gi 543583768 507 K--APRLYPGG 515
Cdd:PTZ00309 502 GevKPEPYPFG 512
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 39-515 3.52e-88

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 287.29  E-value: 3.52e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768   39 IILLGATGDLAKKYLWQGLFQLYldEAGR-GHSFSFHGAALTaPKQGQELMAKALESLScpkDMAPSHCAEHKDQFLQLS 117
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLF--RNGLlPPDFRIVGVARR-DWSVEEFRKVVREAII---KFETDEIDEQWDEFAQRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  118 QYR--QLKTAEDYQALNKDIEaQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQ 195
Cdd:TIGR00871  79 SYVsgDVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  196 QLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVL 275
Cdd:TIGR00871 158 ELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  276 QNHLTEVLTLVAMELPhNVSSAEAVLRHKLQVFQALRGLQRG--SAVVGQY-----QSYSEQVRRELQKPDSfHSLTPTF 348
Cdd:TIGR00871 237 QNHLLQLLALVAMEPP-VSFDADSIRDEKVKVLKALRPIDPDdnNTVRGQYgageiGGVSVPGYLEEEGVDK-DSNTETF 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  349 AAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccVQSEKHWAAAQSQCLPRQLVFHIGhgdlGSPAVLVSRN 428
Cdd:TIGR00871 315 AALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRD----VPSLLFKANERDANPRNALVIRIQ----PDEGVYLKFN 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  429 LFRPSLPSSWKEMEgppglrLFGSPLSDYYAYSPvrerDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLA-HK 507
Cdd:TIGR00871 387 AKKPGLNFETRPVK------LDFSYASRFGELLP----EAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAaNK 456

                         490
                  ....*....|
gi 543583768  508 APRL--YPGG 515
Cdd:TIGR00871 457 GPSPpnYPAG 466
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 39-513 9.62e-85

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 278.17  E-value: 9.62e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  39 IILLGATGDLAKKYLWQGLFQLYldEAGRGH-SFSFHGAALTaPKQGQELMAKALESLScpKDMAPSHCAEHKDQFLQLS 117
Cdd:PRK05722  12 LVIFGATGDLARRKLLPALYNLY--KAGLLPeDFRIIGVARR-DWSDEDFREVVREALK--EFARTPFDEEVWERFLSRL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 118 QYRQ--LKTAEDYQALNKDIEAQLQHAGLReAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQ 195
Cdd:PRK05722  87 YYVSgdVTDPESYERLKELLEELDEERGTG-GNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASAR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 196 QLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNrkAL-DGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDV 274
Cdd:PRK05722 166 ELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFAN--ALfEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDM 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 275 LQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRG----SAVVGQYQS---YSEQV---RRELQKPDsfHSL 344
Cdd:PRK05722 244 VQNHLLQLLALVAMEPPASL-DADSIRDEKVKVLRALRPITPEdvkeNTVRGQYTAgwiGGKPVpgyREEEGVNP--DST 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 345 TPTFAAVLVHIDNLRWEGVPFILMSGKALDERVgyARIL--FKNQAccvqsekHW--AAAQSQCLPRQLVFHIghgdlgS 420
Cdd:PRK05722 321 TETFVALKLEIDNWRWAGVPFYLRTGKRLPKKV--TEIVivFKPPP-------HNlfEESAEELGPNKLVIRI------Q 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 421 P--AVLVSRNLFRPSlpsswkemegpPGLRLFGSPLS-DYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFW 497
Cdd:PRK05722 386 PdeGISLRFNAKVPG-----------EGMELRPVKLDfSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWV 454

                        490
                 ....*....|....*.
gi 543583768 498 TPLLESLAHKAPRLYP 513
Cdd:PRK05722 455 DPILEAWEADGGPPPP 470
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
569-793 2.57e-84

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 267.57  E-value: 2.57e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  569 AWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQ 648
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  649 AHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALVANSS---FDLVLLGMGADGHTASLFPQSPTGLDGEQ 725
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  726 LVV-LTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV-GHEPKKWPISGVLPHSGQLVW 793
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 34-386 9.34e-84

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 275.83  E-value: 9.34e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  34 QGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSFSFHGAALTaPKQGQELMAKALESLSCPKDMApshcAEHKDQF 113
Cdd:PLN02539  15 TGCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEVHIFGYARS-KITDEELRDRIRGYLKDEKNAP----AEAVSKF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 114 LQLSQYRQ--LKTAEDYQALNKDI-EAQLQHAGLREAG-RIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGH 189
Cdd:PLN02539  90 LQLIKYVSgaYDSEEGFRRLDKEIsEHEISKNSAEGSSrRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 190 DHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDgLWNRHHVERVEIIMKETVDAEGRTSFYEEYG 269
Cdd:PLN02539 170 DLESAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLP-LWNRDNIANVQIVFREDFGTEGRGGYFDEYG 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 270 VIRDVLQNHLTEVLTLVAMELPhnVS-SAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYseqvRRELQKPDsfHSLTPTF 348
Cdd:PLN02539 249 IIRDIIQNHLLQVLCLVAMEKP--VSlKPEHIRDEKVKVLQSVEPIKDEEVVLGQYEGY----RDDPTVPD--DSNTPTF 320

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 543583768 349 AAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKN 386
Cdd:PLN02539 321 ASVVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKD 358
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 572-795 1.00e-79

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 255.18  E-value: 1.00e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 572 EELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAhYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHL 651
Cdd:cd01400    1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 652 LQHVRIPYYNIHPMPVHLqqrlcaEEDQGAQIYAREISALVANS-SFDLVLLGMGADGHTASLFPQSP-TGLDGEQLVVL 729
Cdd:cd01400   80 LSHVAIPAANIHPIPTEL------GPEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 543583768 730 TT-SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSGQLVWYM 795
Cdd:cd01400  154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 39-377 3.57e-78

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 260.78  E-value: 3.57e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  39 IILLGATGDLAKKYLWQGLFQLYLDeaGR-GHSFSFHGAALTAPKQGQ--ELMAKALESLScPKDMAPSHCaehkDQFLQ 115
Cdd:COG0364   12 LVIFGATGDLARRKLLPALYNLYRD--GLlPEGFRIIGVARRDWSDEEfrEEVREALEEFS-RKPFDEEVW----ERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 116 LSQYRQL--KTAEDYQALNKDIEAQlqHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFS 193
Cdd:COG0364   85 RLHYVSGdfTDPEGYERLKELLEEL--DEERTPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLAS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 194 AQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRD 273
Cdd:COG0364  163 ARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 274 VLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRG----SAVVGQY---QSYSEQV---RRELQKPDsfHS 343
Cdd:COG0364  242 MVQNHLLQLLCLVAMEPPASL-DADAIRDEKVKVLRALRPITPEdvaeNTVRGQYtagWIGGEPVpgyREEPGVAP--DS 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 543583768 344 LTPTFAAVLVHIDNLRWEGVPFILMSGKALDERV 377
Cdd:COG0364  319 TTETFVALKLEIDNWRWAGVPFYLRTGKRLPERV 352
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 37-516 2.34e-77

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 261.83  E-value: 2.34e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  37 VSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHsFSFHGAALTAPKQGqELMAKALESLSCPKDMApSHCAEHKDQFLQL 116
Cdd:PLN02333 118 VSITVVGASGDLAKKKIFPALFALYYEGCLPEH-FTIFGYARSKMTDA-ELRNMVSKTLTCRIDKR-ENCGEKMEEFLKR 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 117 SQYR--QLKTAEDYQALNKDIEaqlQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVVLEKPFGHDHFSA 194
Cdd:PLN02333 195 CFYHsgQYDSQEHFAELDKKLK---EHEGGRVSNRLFYLSIPPNIFVDAVKCASSSASSVNG-WTRVIVEKPFGRDSESS 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 195 QQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDV 274
Cdd:PLN02333 271 AALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNL-IFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDI 349

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 275 LQNHLTEVLTLVAMELPhnVS-SAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSE-QVRRELQKPDSF---HSLTPTFA 349
Cdd:PLN02333 350 MQNHLLQILALFAMETP--VSlDAEDIRNEKVKVLRSMRPIQLEDVVIGQYKSHTKgGVTYPAYTDDKTvpkGSLTPTFA 427

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 350 AVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvqsekhwaaaqsqcLPRQLVFHIGHGDLG-SPAVLVSRn 428
Cdd:PLN02333 428 AAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRH------------------VPGNLYNRNFGTDLDqATNELVIR- 488

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 429 lFRPSLPSSWKEMEGPPGL--RLFGSPLSDYYAYSPVRE-RDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLA 505
Cdd:PLN02333 489 -VQPDEAIYLKINNKVPGLgmRLDRSNLNLLYAARYSKEiPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELE 567

                        490
                 ....*....|...
gi 543583768 506 HKA--PRLYPGGA 516
Cdd:PLN02333 568 EKKiiPEYYPYGS 580
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 29-516 1.00e-76

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 259.18  E-value: 1.00e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  29 QAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLdEAGRGHSFSFHGAALTAPKQgQELMAKALESLSCPKDMApSHCAE 108
Cdd:PLN02640  81 HAEKGESTLSITVVGASGDLAKKKIFPALFALFY-EDWLPENFTVFGYARTKLTD-EELRDMISSTLTCRIDQR-ENCGD 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 109 HKDQFLQLSQYR--QLKTAEDYQALNKDIEAqlqhaglREAG----RIFYFSVPPFAYEDIARNINSSCRPGPGaWLRVV 182
Cdd:PLN02640 158 KMDQFLKRCFYHsgQYDSEEDFAELNKKLKE-------KEAGklsnRLFYLSIPPNIFVDVVRCASLRASSENG-WTRVI 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 183 LEKPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRT 262
Cdd:PLN02640 230 VEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNL-VFEPLWSRNYIRNVQLIFSEDFGTEGRG 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 263 SFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQVRRELQKPDS-- 340
Cdd:PLN02640 309 GYFDNYGIIRDIMQNHLLQILALFAMETPVSL-DAEDIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGKSYPAYTDDpt 387

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 341 --FHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQsEKHWAAAQSQClPRQLVFHIGHGDl 418
Cdd:PLN02640 388 vpKHSLTPTFAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLY-KRNFGTDLDKA-TNELVLRVQPDE- 464

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 419 gspAVLVSRNLFRPSLpsswkemegppGLRLFGSPLSDYYAYSPVRE-RDAHSVLLSHIFHGRKNFFITTENLLASWNFW 497
Cdd:PLN02640 465 ---AIYLKINNKVPGL-----------GMRLDRSDLNLLYRARYPREiPDAYERLLLDAIEGERRLFIRSDELDAAWALF 530

                        490       500
                 ....*....|....*....|.
gi 543583768 498 TPLLESLAHK--APRLYPGGA 516
Cdd:PLN02640 531 TPLLKELEEKkiIPELYPYGS 551
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
39-515 3.64e-75

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 252.51  E-value: 3.64e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  39 IILLGATGDLAKKYLWQGLFQLYLDeaGRGH-SFSFHGAALTAPKQGQ--ELMAKALESLSCPKDMAPSHcaehkDQFLQ 115
Cdd:PRK12853  11 LVIFGATGDLARRKLLPALYRLARA--GLLPeDLRIIGVGRDDWSDEQwrARVRESLRAFGADGFDDAVW-----DRLAA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 116 LSQYRQ--LKTAEDYQALNKDIEAQlqhaglreAGRIFYFSVPPFAYEDIARNINSScrpG-PGAWLRVVLEKPFGHDHF 192
Cdd:PRK12853  84 RLSYVQgdVTDPADYARLAEALGPG--------GNPVFYLAVPPSLFAPVVENLGAA---GlLPEGRRVVLEKPFGHDLA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 193 SAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIR 272
Cdd:PRK12853 153 SARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANA-LLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 273 DVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGL--QRGSAVVGQYQSYS---EQVRRELQKPD-SFHSLTP 346
Cdd:PRK12853 232 DMVQNHLLQLLALVAMEPPASF-DADAVRDEKAKVLRAIRPLdpDDVHTVRGQYTAGTvggEPVPGYREEPGvDPDSRTE 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 347 TFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQSEKHWAAaqsqclPRQLVFHIGhgdlgsPAVLVS 426
Cdd:PRK12853 311 TFVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTGVEP------PNRLVIRLQ------PDEGIS 378

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 427 RNLFRPSlpsswkemegpPGLRLFGSPLSDYYAY-SPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLA 505
Cdd:PRK12853 379 LELNVKR-----------PGPGMRLRPVELDADYaDDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWA 447

                        490
                 ....*....|..
gi 543583768 506 --HKAPRLYPGG 515
Cdd:PRK12853 448 adPVPPHEYPAG 459
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
239-515 2.88e-67

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 225.01  E-value: 2.88e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  239 LWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPhnVS-SAEAVLRHKLQVFQALRGLQRG 317
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPP--VSfDAEDIRDEKVKVLRSLRPITPE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  318 S----AVVGQYQSYS---EQV---RRELQKPDsfHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQ 387
Cdd:pfam02781  91 DvednVVRGQYGAGWiggEPVpgyREEEGVPP--DSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFKDV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  388 ACCVQSEKHwaaaqsQCLPRQLVFHIGHGdlgsPAVLVSRNLFRPslpsswkemeGpPGLRLFGSPLS-DYYAYSPVRER 466
Cdd:pfam02781 169 PHNLFRDPG------TLPPNELVIRIQPD----EGIYLKFNAKVP----------G-LGMRLRPVELDfSYSDRFGERIP 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 543583768  467 DAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGG 515
Cdd:pfam02781 228 EAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 29-525 5.90e-63

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 219.14  E-value: 5.90e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  29 QAQELQGHVSIILLGATGDLAKKYLWQGLFqlYLDEAGRGHS-FSFHGAALtAPKQGQELMAKALESLscpkDMAPSHCA 107
Cdd:PRK12854   4 QGTGPAPPTVFVLFGATGDLAKRKLLPGLF--HLARAGLLPPdWRIVGTGR-GDVSAEAFREHARDAL----DEFGARKL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 108 EHK--DQFLQLSQYRQLK-TAEDYQALnKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSScrpGPGAWLRVVLE 184
Cdd:PRK12854  77 DDGewARFAKRLRYVPGGfLSAGPGAL-AAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGEA---GLAEGSRVVME 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 185 KPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIIMKETVDAEGRTSF 264
Cdd:PRK12854 153 KPFGTDLASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANG-LFEPIWNREFIDHVQIDVPETLGVDTRAAF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 265 YEEYGVIRDVLQNHLTEVLTLVAMELPHNVsSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQ--VRrelqkPDsfh 342
Cdd:PRK12854 232 YDATGAYRDMVVTHLFQVLAFVAMEPPTAL-EPDAISEEKNKVFRSMRPLDPAEVVRGQYSGYRDEpgVA-----PD--- 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 343 SLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNqaccvqsekhwaaaqsqclPRQLVFHIGHGDLGSPA 422
Cdd:PRK12854 303 STTETFVALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFRE-------------------PPYSMFPAGSVGAQGPD 363

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 423 VLVSRNLFRPSLPSSWKEMEGPPGLRLfgSPLSDYYAYSPVRER----DAHSVLLSHIFHGRKNFFITTENLLASWNFWT 498
Cdd:PRK12854 364 HLTFDLADNSKVSLSFYGKRPGPGMRL--DKLSLQFSLKDTGPKgdvlEAYERLILDALRGDHTLFTTADGIESLWEVSQ 441

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 543583768 499 PLLESlaHKAPRLYPGG-----------AENGRLLDFE 525
Cdd:PRK12854 442 PLLED--PPPVKPYAPGswgpnaihqlaAPDAWRLPFE 477
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 571-799 9.83e-56

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.91  E-value: 9.83e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 571 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESNFQGL 647
Cdd:COG0363   10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKegGLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 648 QAHLLQHVRIPYYNIHPMPVHLqqrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLV 727
Cdd:COG0363   90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 728 VLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRV--GHEPKKWPISGVLPHSgQLVW 793
Cdd:COG0363  162 TLDEStrqanarffgsiPKVPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                 ....*.
gi 543583768 794 YMDYDA 799
Cdd:COG0363  238 FLDEAA 243
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
40-222 4.37e-43

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 154.12  E-value: 4.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768   40 ILLGATGDLAKKYLWQGLFQLYLDeaGRGH-SFSFHGAALTaPKQGQELMAKALESLSCPKDmapsHCAEHKDQFLQLSQ 118
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRD--GLLPeGFRIIGVARR-DLSDEEFRERVREALKEFKE----LDEEKWDRFLERLH 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768  119 YRQ--LKTAEDYQALNKDIEaqlQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQQ 196
Cdd:pfam00479  74 YVSgdFDDPESYEKLKERLE---EHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESARE 150

                         170       180
                  ....*....|....*....|....*.
gi 543583768  197 LATELGTFFQEEEMYRVDHYLGKQAV 222
Cdd:pfam00479 151 LNDQLAKVFKEEQIYRIDHYLGKETV 176
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 571-799 2.91e-29

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 117.65  E-value: 2.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 571 SEELISKLANDIEATAVRAVRRFGQFHLALSGGSSpVALFQQLATAHYG--FPWAHTHLWLVDERCVPLSDPESNFQGLQ 648
Cdd:PLN02360  19 LDELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYNktVDWAKWYIFWADERVVAKNHADSNYKLAK 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 649 AHLLQHVRIPYYNIHPmpvhLQQRLCAEEdqGAQIYAREISALVANSS-----------FDLVLLGMGADGHTASLFPQS 717
Cdd:PLN02360  98 DGLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNH 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 718 PT-GLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTL-VSRVGHEP--KKWPISGVLPHSGQLVW 793
Cdd:PLN02360 172 PAlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVW 251


                 ....*.
gi 543583768 794 YMDYDA 799
Cdd:PLN02360 252 FLDKPA 257
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 567-782 3.08e-16

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 78.68  E-value: 3.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 567 VSAWSEELISKLandieatavraVRRFGQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERcVPLS--DPES 642
Cdd:cd01399    3 MSEAAAELIAEL-----------IREKPPAVLGLATGSTPLGVYEELIELHKegGLSFSNVTTFNLDEY-VGLPpdHPQS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 643 NFQGLQAHLLQHVRIPYYNIHPMPVhlqqrLCAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTAslFPQSPTGLD 722
Cdd:cd01399   71 YHYFMRENLFDHIDIKPENIHIPDG-----NAADLEAECRRYEALIAEA---GGIDLQLLGIGENGHIG--FNEPGSSLD 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 543583768 723 GE-QLVVLTTSPSQ------------PHRRMSLSLPLINRAKKVAVLVMGRMKREIttlVSRVGHEP--KKWPIS 782
Cdd:cd01399  141 SRtRVVTLDESTRQanarffdgdedvPTQAITMGIGTIMKAKEILLLATGEGKAEA---VKKALEGPvtEECPAS 212
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 567-799 1.20e-09

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 59.77  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 567 VSAWSEELISKLANDIEATAVRavrrfgQFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDERC-VPLSDPESN 643
Cdd:PTZ00285  12 VADYTSNYIIKRINDFKPTSDR------PFVLGLPTGSTPLPTYQELIRAYRegRVSFSNVVTFNMDEYVgLPRDHPQSY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 644 FQGLQAHLLQHVRIPYYNihpmpVHLQQRLCAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTASLFPQSPtgLDG 723
Cdd:PTZ00285  86 HYFMKENFFDHVDIKEEN-----RHILNGTAPDLEEECRRYEEKIRAV---GGIDLFLAGIGTDGHIAFNEPGSS--LDS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 724 EQLVV-LTTSP------------SQ-PHRRMSLSLPLINRAKKVAVLVMGRMKREITT--LVSRVGHepkKWPISGVLPH 787
Cdd:PTZ00285 156 RTRVKsLNQETidanarffgndiSKvPTMALTVGIRTIMEAREVLLLATGASKAIAVArcVEGGVTH---MCPASALQMH 232

                        250
                 ....*....|..
gi 543583768 788 SgQLVWYMDYDA 799
Cdd:PTZ00285 233 P-AAVLCLDEDA 243
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 596-710 3.52e-09

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 56.59  E-value: 3.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 596 FHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCA 675
Cdd:cd00458   22 MVIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFPTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSLPIEKAC 101

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 543583768 676 EEdqgaqiYAREIsaLVANSSFDLVLLGMGADGHT 710
Cdd:cd00458  102 EK------YEREI--LDQVDAIDLAVDGAGYRAGT 128
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 567-782 9.61e-08

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 54.07  E-value: 9.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 567 VSAWSEELISKLANDIEATAVRAvrrfgqFHLALSGGSSPVALFQQLATAHY--GFPWAHTHLWLVDE-RCVPLSDPES- 642
Cdd:PRK00443  12 VGKWAARHIANRINAFLPTKERP------FVLGLATGSSPLETYKALIELHKagKVDFSRVTTFNLDEyVGLPADHPESy 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 643 -NFqgLQAHLLQHVRIPYYNIHpmpvhLQQRLCAEEDQGAQIYAREIsalVANSSFDLVLLGMGADGHTAslFPQSPTGL 721
Cdd:PRK00443  86 rYF--MRENFFDHVDIPPENIN-----LLNGNAPDPEAECRRYEEKI---KSAGGIDLQILGIGENGHIA--FNEPGSSF 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 543583768 722 DGEQLVV-LTTSPSQ-------------PHRRMSLSLPLINRAKKVAVLVMGRMKREIT--TLVSRVGHEpkkWPIS 782
Cdd:PRK00443 154 ASRTRIKtLTEDTRIansrffdgdieqvPKYALTVGVGTILDAKEIMLLAPGHNKAEAVkaAVEGPVNHM---WPAS 227
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 571-765 1.14e-06

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 52.34  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 571 SEELISKLANDIeATAVRAVRRFGQFH-LALSGGSSPVALFQQLATAH--YGFPWAHTHLWLVDERcVPLS--DPESNFQ 645
Cdd:PRK02122  36 SEEASRAVAQEI-ATLIRERQAEGKPCvLGLATGSSPIGVYAELIRMHreEGLSFKNVITFNLDEY-YPMQpdSLQSYHR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 646 GLQAHLLQHVRIPYYNIHPMPVHLQQrlcAEEDQGAQIYAREISALvanSSFDLVLLGMGADGHTAslFPQSPTGLD-GE 724
Cdd:PRK02122 114 FMKENLFDHVDIPPENIHIPDGTIPK---EEIDEYCRDYEEKIEAA---GGIDFQLLGIGRTGHIG--FNEPGSGRNsRT 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 543583768 725 QLVVLTTS------------PSQPHRRMSLSLPLINRAKKVAVLVMGRMKREI 765
Cdd:PRK02122 186 RLVTLDHItrrdaasdffgeENVPRKAITMGVGTILKARRIVLLAWGEHKAPI 238
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
597-709 9.07e-06

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 47.82  E-value: 9.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583768 597 HLALSGGSSPVALFQQLATAHYGFPW-AHTHLWLVDErcVPLSDPES---NFQGLQAHLLQHVRIPYYNIHPMPVhlqqr 672
Cdd:PRK12358  31 NLAITAGSTPKGMYEYLITLVKGKAWyDNVHYYNFDE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLTI----- 103

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 543583768 673 lcaeedqgaQIYAREISALVANSSFDLVLLGMGADGH 709
Cdd:PRK12358 104 ---------DNYREHDQKLARDGGLDLVVLGLGADGH 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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