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Conserved domains on  [gi|543583715|ref|NP_001269539|]
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protein lifeguard 4 isoform d [Homo sapiens]

Protein Classification

Bax inhibitor 1 family protein( domain architecture ID 1847)

Bax inhibitor 1 family protein similar to Saccharomyces cerevisiae Bax inhibitor 1 that links the unfolded protein response and programmed cell death, and mediates mitochondrial-dependent apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1-like super family cl00473
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 15-205 2.80e-76

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


The actual alignment was detected with superfamily member cd10429:

Pssm-ID: 469783  Cd Length: 233  Bit Score: 229.03  E-value: 2.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  15 VLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIIL 94
Cdd:cd10429   42 LLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGSLILLIALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  95 QAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILC-LSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHK 173
Cdd:cd10429  122 QALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALIlLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKR 201

                        170       180       190
                 ....*....|....*....|....*....|..
gi 543583715 174 LSPEEYVLAAISLYLDIINLFLHLLRFLEAVN 205
Cdd:cd10429  202 LSPDEYILAAISLYLDIINLFLSILRILAAMN 233
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 15-205 2.80e-76

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 229.03  E-value: 2.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  15 VLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIIL 94
Cdd:cd10429   42 LLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGSLILLIALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  95 QAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILC-LSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHK 173
Cdd:cd10429  122 QALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALIlLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKR 201

                        170       180       190
                 ....*....|....*....|....*....|..
gi 543583715 174 LSPEEYVLAAISLYLDIINLFLHLLRFLEAVN 205
Cdd:cd10429  202 LSPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 16-201 1.10e-31

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 114.19  E-value: 1.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715   16 LLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALIL----NRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVY 91
Cdd:pfam01027  15 LLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLlarkRKYSSNVALLLLLAFTLLMGLTLGPLLLVYTGA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715   92 IILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLM 171
Cdd:pfam01027  95 IIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGVLLFSGFILYDTQRII 174

                         170       180       190
                  ....*....|....*....|....*....|...
gi 543583715  172 HK---LSPEEYVLAAISLYLDIINLFLHLLRFL 201
Cdd:pfam01027 175 KRygeYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 15-201 2.38e-31

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 113.74  E-value: 2.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  15 VLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFAL--ILNRHKYPLNLYLLFGFTLLEALTVAVVVTFY---- 88
Cdd:COG0670   34 LLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLskLANRANSAAALALLFAYTALMGLTLSPILLVYtgls 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  89 DVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTH 168
Cdd:COG0670  114 GPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQ 193

                        170       180       190
                 ....*....|....*....|....*....|....
gi 543583715 169 SLMHK-LSPEEYVLAAISLYLDIINLFLHLLRFL 201
Cdd:COG0670  194 RIKHGyETNKQYIMAALSLYLDFINLFLSLLRLL 227
PRK10447 PRK10447
FtsH protease modulator YccA;
38-201 3.10e-03

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 37.51  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  38 SPALILLFAlGSLGLIFaLILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVY----IILQAFILTTTVFFGLTVYTLQ 113
Cdd:PRK10447  49 SPGLILTLV-GMYGLMF-LTYKTANKPTGILSAFAFTGFLGYILGPILNTYLSAgmgdVIALALGGTALVFFCCSAYVLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715 114 SKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHKlSPEEYVLAAISLYLDIINL 193
Cdd:PRK10447 127 TRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILISSGAILFETSNIIHG-GETNYIRATVSLYVSLYNI 205


                 ....*...
gi 543583715 194 FLHLLRFL 201
Cdd:PRK10447 206 FVSLLSIL 213
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 15-205 2.80e-76

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 229.03  E-value: 2.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  15 VLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIIL 94
Cdd:cd10429   42 LLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGSLILLIALYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKIVL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  95 QAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILC-LSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHK 173
Cdd:cd10429  122 QALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALIlLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKR 201

                        170       180       190
                 ....*....|....*....|....*....|..
gi 543583715 174 LSPEEYVLAAISLYLDIINLFLHLLRFLEAVN 205
Cdd:cd10429  202 LSPDEYILAAISLYLDIINLFLSILRILAAMN 233
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 15-202 4.60e-45

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 148.33  E-value: 4.60e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  15 VLLTTVTSTVFLYFESvrtfvhESPALILLFALGS--LGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYI 92
Cdd:cd06181   17 LLLTAATATAFTVCDP------GWYWSPALMGLLTsmLALMATAAMIRAKMPVNLILLFGFTGLMGYVVGPLLFFYGPTI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  93 ILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMH 172
Cdd:cd06181   91 LLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAVGLVLFCGFLLYDTQLIIH 170

                        170       180       190
                 ....*....|....*....|....*....|..
gi 543583715 173 K--LSPEEYVLAAISLYLDIINLFLHLLRFLE 202
Cdd:cd06181  171 KaeVGPEDYINACISLYLDIINIFIRLLTILA 202
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 15-201 1.49e-32

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 116.49  E-value: 1.49e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  15 VLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILN---RHKYPLNLYLLFGFTLLEALTVAVVVTFYDVY 91
Cdd:cd10428   23 LLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCeglRRRFPWNLILLGIFTLAMSYMLGTIASFYDTK 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  92 IILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLM 171
Cdd:cd10428  103 AVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHIVYASLGALLFSLYLAVDTQLLM 182

                        170       180       190
                 ....*....|....*....|....*....|....
gi 543583715 172 ----HKLSPEEYVLAAISLYLDIINLFLHLLRFL 201
Cdd:cd10428  183 ggrkYELSPEEYIFAALNIYVDIVNIFLYILQLI 216
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 16-201 1.10e-31

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 114.19  E-value: 1.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715   16 LLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALIL----NRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVY 91
Cdd:pfam01027  15 LLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLlarkRKYSSNVALLLLLAFTLLMGLTLGPLLLVYTGA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715   92 IILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLM 171
Cdd:pfam01027  95 IIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGVLLFSGFILYDTQRII 174

                         170       180       190
                  ....*....|....*....|....*....|...
gi 543583715  172 HK---LSPEEYVLAAISLYLDIINLFLHLLRFL 201
Cdd:pfam01027 175 KRygeYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 15-201 2.38e-31

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 113.74  E-value: 2.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  15 VLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFAL--ILNRHKYPLNLYLLFGFTLLEALTVAVVVTFY---- 88
Cdd:COG0670   34 LLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLskLANRANSAAALALLFAYTALMGLTLSPILLVYtgls 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  89 DVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTH 168
Cdd:COG0670  114 GPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQ 193

                        170       180       190
                 ....*....|....*....|....*....|....
gi 543583715 169 SLMHK-LSPEEYVLAAISLYLDIINLFLHLLRFL 201
Cdd:COG0670  194 RIKHGyETNKQYIMAALSLYLDFINLFLSLLRLL 227
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 15-201 9.91e-29

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 106.49  E-value: 9.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  15 VLLTTVTSTVFLYFESVRTFVheSPALILLFALGSLGLIFALILNRHKYPL--NLYLLFGFTLLEALTVAVVVTFYDVYI 92
Cdd:cd10432   17 LLLTAVGAYVGASTPALLLIA--GSPLMWVLLIAELALVFGLSFRINKMSVatALPLFFAFAALTGLTLSPILLVYTGAS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  93 ILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMH 172
Cdd:cd10432   95 IAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISAIGVLIFSGLIAYDTQRIKR 174

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 543583715 173 -------KLSPEEYVLAAISLYLDIINLFLHLLRFL 201
Cdd:cd10432  175 myeagggESGYKDAIMGALSLYLDFINLFLFLLRLF 210
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 42-205 2.02e-19

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 82.25  E-value: 2.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  42 ILLFALGSLGLIFALILNRHKyPLNLYLLFGFTLLEALTVAVVVTFYDVY-----IILQAFILTTTVFFGLTVYTLQSKK 116
Cdd:cd10433   38 LLLTLVGAYGLLFLIEKTRNS-AWGIVLVFAFTGFMGYTLGPILNMYLALpnggqIIMTALGGTAAIFFGLSAYALTTKK 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715 117 DFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHKlSPEEYVLAAISLYLDIINLFLH 196
Cdd:cd10433  117 DFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFILYDTSRIIHG-GETNYIMATVSLYVSIYNLFVS 195


                 ....*....
gi 543583715 197 LLRFLEAVN 205
Cdd:cd10433  196 LLNLLGAFS 204
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 43-201 9.58e-12

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 61.47  E-value: 9.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  43 LLFALGSLGLIFALILNRHKY---PLNLYLLFGFTLLEALTVAVVVTFY---DVYIILQAFILTTTVFFGLTVYTLQSKK 116
Cdd:cd10430   41 LLTGLLSLGLSLWLAFTPSTGknePKRLGLLLGFAFLTGASLGPLLDLViaiNPSIIVTAFLGTAVIFACFSLAALLAKR 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715 117 -DFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHK--LSPEEYVLAAISLYLDIINL 193
Cdd:cd10430  121 rEYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELYLGLLVFCGFVLFDTQMIIEKaeNGDRDYIWHALDLFVDFVAL 200


                 ....*...
gi 543583715 194 FLHLLRFL 201
Cdd:cd10430  201 FRRLLIIL 208
PRK10447 PRK10447
FtsH protease modulator YccA;
38-201 3.10e-03

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 37.51  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715  38 SPALILLFAlGSLGLIFaLILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVY----IILQAFILTTTVFFGLTVYTLQ 113
Cdd:PRK10447  49 SPGLILTLV-GMYGLMF-LTYKTANKPTGILSAFAFTGFLGYILGPILNTYLSAgmgdVIALALGGTALVFFCCSAYVLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543583715 114 SKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHKlSPEEYVLAAISLYLDIINL 193
Cdd:PRK10447 127 TRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILISSGAILFETSNIIHG-GETNYIRATVSLYVSLYNI 205


                 ....*...
gi 543583715 194 FLHLLRFL 201
Cdd:PRK10447 206 FVSLLSIL 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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