phage associated protein [Klebsiella phage 0507-KN2-1]
Protein Classification
ParB N-terminal domain-containing protein( domain architecture ID 706361)
ParB N-terminal domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| ParB_N_Srx super family | cl28891 | ParB N-terminal domain and sulfiredoxin protein-related families; The ParB N-terminal domain ... |
57-123 | 1.34e-03 | ||
ParB N-terminal domain and sulfiredoxin protein-related families; The ParB N-terminal domain/Sulfiredoxin (Srx) superfamily contains proteins with diverse activities. Many of the families are involved in segregation and competition between plasmids and chromosomes. Several families share similar activities with the N-terminal domain of ParB (Spo0J in Bacillus subtilis), a DNA-binding component of the prokaryotic parABS partitioning system. Also within this superfamily is sulfiredoxin (Srx; reactivator of oxidatively inactivated 2-cys peroxiredoxins), RepB N-terminal domain (plasmid segregation replication protein B like protein), nucleoid occlusion protein, KorB N-terminal domain partition protein of low copy number plasmid RK2, irbB (immunoglobulin-binding regulator that activates eib genes), N-terminal domain of sopB protein (promotes proper partitioning of F1 plasmid), fertility inhibition factors OSA and FiwA,DNA sulfur modification protein DndB, and a ParB-like toxin domain. Other activities includes a StrR (regulator in the streptomycin biosynthetic gene cluster), and a family containing a Pyrococcus furiosus nuclease and putative transcriptional regulators sbnI (Staphylococcus aureus siderophore biosynthetic gene cluster ). Nuclease activity has also been reported in Arabidopsis Srx. The actual alignment was detected with superfamily member cd16400: Pssm-ID: 452888 [Multi-domain] Cd Length: 72 Bit Score: 35.60 E-value: 1.34e-03
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| Name | Accession | Description | Interval | E-value | ||
| ParB_Srx_like_nuclease | cd16400 | ParB/Srx_like nuclease and putative transcriptional regulators related to SbnI; This family ... |
57-123 | 1.34e-03 | ||
ParB/Srx_like nuclease and putative transcriptional regulators related to SbnI; This family contains a Pyrococcus Furiosus enzyme reported to have DNA nuclease activity and resembles the N-terminal domain of ParB proteins of the parABS bacterial chromosome partitioning system. This sub-family also includes siderophore staphylobactin biosynthesis protein SbnI. 60% of the P. furiosus nuclease activity was retained at 90 degree C, suggesting a physiological role in the organism, which can grow in temperatures as high as 100 degrees Celsius. The protein has endo- and exo-nuclease activity vs. single- and double-stranded DNA, and nuclease activity was lost in methylated proteins prepared for structure solution. This family has a fairly well-conserved DGHHR motif that corresponds to the same structural position as the phosphorylation site (a portion of the ATP-Mg-binding site) of sulfiredoxin and the arginine-rich ParB BoxII of ParB. Pssm-ID: 319257 [Multi-domain] Cd Length: 72 Bit Score: 35.60 E-value: 1.34e-03
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| Name | Accession | Description | Interval | E-value | ||
| ParB_Srx_like_nuclease | cd16400 | ParB/Srx_like nuclease and putative transcriptional regulators related to SbnI; This family ... |
57-123 | 1.34e-03 | ||
ParB/Srx_like nuclease and putative transcriptional regulators related to SbnI; This family contains a Pyrococcus Furiosus enzyme reported to have DNA nuclease activity and resembles the N-terminal domain of ParB proteins of the parABS bacterial chromosome partitioning system. This sub-family also includes siderophore staphylobactin biosynthesis protein SbnI. 60% of the P. furiosus nuclease activity was retained at 90 degree C, suggesting a physiological role in the organism, which can grow in temperatures as high as 100 degrees Celsius. The protein has endo- and exo-nuclease activity vs. single- and double-stranded DNA, and nuclease activity was lost in methylated proteins prepared for structure solution. This family has a fairly well-conserved DGHHR motif that corresponds to the same structural position as the phosphorylation site (a portion of the ATP-Mg-binding site) of sulfiredoxin and the arginine-rich ParB BoxII of ParB. Pssm-ID: 319257 [Multi-domain] Cd Length: 72 Bit Score: 35.60 E-value: 1.34e-03
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