|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-439 |
0e+00 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 560.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 8 GKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEET 87
Cdd:cd13140 1 GPILKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 88 KSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFII 167
Cdd:cd13140 81 RKYARNALQLNLLLGILYGLLLLLFAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 168 NTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLPV 247
Cdd:cd13140 161 NAIGLVLNIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLPV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 248 SLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVI 327
Cdd:cd13140 241 ALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 328 GLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIVFNTLRIPGALLL 407
Cdd:cd13140 321 GLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVFNGLRIPLALLL 400
|
410 420 430
....*....|....*....|....*....|...
gi 543000758 408 SAGLG-LSGVWWSISLSSIMKGIILTSWFIIFL 439
Cdd:cd13140 401 SPTGLgLNGIWWAISISSILKGIILTIWFLLYK 433
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
5-434 |
1.46e-93 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 289.35 E-value: 1.46e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 5 LTEGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDT 84
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 85 EETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTP 164
Cdd:COG0534 81 EEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPE-VLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 165 FIINTIGLVIAITLDPLLILGigpfPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFG 244
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 245 LPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGII 324
Cdd:COG0534 236 LPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 325 SVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIVFNTL-RIPG 403
Cdd:COG0534 316 LGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLvRLPL 395
|
410 420 430
....*....|....*....|....*....|..
gi 543000758 404 ALLLSAGLG-LSGVWWSISLSSIMKGIILTSW 434
Cdd:COG0534 396 AYLLAFLGLgLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-435 |
1.02e-86 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 271.69 E-value: 1.02e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 12 KKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYI 91
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 92 RHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIG 171
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPE-VIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 172 LVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLPVSLQS 251
Cdd:cd13137 160 NVLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 252 GAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVIGLIT 331
Cdd:cd13137 240 LLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 332 SSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSL-NGIVFNTLRIPGALLLSAG 410
Cdd:cd13137 320 GLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIiNLISMWLVRLPLAYLLGFV 399
|
410 420
....*....|....*....|....*..
gi 543000758 411 LGL--SGVWWSISLSSIMKGIILTSWF 435
Cdd:cd13137 400 LGLglTGIWLAMFVDTIVRAILLLYRF 426
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
10-438 |
9.08e-86 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 269.33 E-value: 9.08e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 10 ILKKLIILALPIMGTSFIQMAYNLADMLWVG-ILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETK 88
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGqFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 89 SYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIIN 168
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAE-ILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 169 TIGLVIAITLDPLLILGigpfPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLPVS 248
Cdd:cd13138 160 IIACVLNIILDLLFIAV----FHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 249 LQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVIG 328
Cdd:cd13138 236 LQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 329 LITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIV-FNTLRIPGALLL 407
Cdd:cd13138 316 LIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILrLWLVRIPLAYLL 395
|
410 420 430
....*....|....*....|....*....|...
gi 543000758 408 SAGLGL--SGVWWSISLSSIMKGIILTSWFIIF 438
Cdd:cd13138 396 SRLTGLglFGIWLAMPISNILSAIICIIYYRKG 428
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-436 |
5.28e-82 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 259.82 E-value: 5.28e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 4 NLTEGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKD 83
Cdd:cd13142 3 NILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 84 TEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKT 163
Cdd:cd13142 83 YDKANKVAGQTFSFVIILSLILAVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 164 PFIINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRF 243
Cdd:cd13142 163 PMKIMFGSVLLNVILDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPDWEWLKKIFRI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 244 GLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGI 323
Cdd:cd13142 243 GLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 324 ISVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIV-FNTLRIP 402
Cdd:cd13142 323 IFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILrLWVIRIP 402
|
410 420 430
....*....|....*....|....*....|....*.
gi 543000758 403 GALLLSAGLG--LSGVWWSISLSSIMKGIILTSWFI 436
Cdd:cd13142 403 LAYLLAYVLGlgVTGIWIAMAISNIVAALIALAWFK 438
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
18-436 |
1.32e-63 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 211.41 E-value: 1.32e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 18 ALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYIRHSLQL 97
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 98 TVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGLVIAIT 177
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEE-VIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 178 LDPLLILGIGPfPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLPVSLQSGAFTLI 257
Cdd:cd12082 160 LDPLLIFGLGP-PELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 258 GMVIARILSNW-GPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVIGLITSSLLV 336
Cdd:cd12082 239 LLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 337 FLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIVFN-TLRIPGALLLSAGLG-LS 414
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYwVVRLPLAYVLAYLGLgLY 398
|
410 420
....*....|....*....|..
gi 543000758 415 GVWWSISLSSIMKGIILTSWFI 436
Cdd:cd12082 399 GIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-396 |
3.23e-57 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 195.03 E-value: 3.23e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 12 KKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYI 91
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 92 RHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIG 171
Cdd:cd13134 83 GVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPE-LLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 172 LVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLPVSLQS 251
Cdd:cd13134 162 NILNIVGNYLLIFGWFGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAGEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 252 GAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVIGLIT 331
Cdd:cd13134 242 LSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAV 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 543000758 332 SSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIVF 396
Cdd:cd13134 322 ALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIIS 386
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-430 |
7.14e-56 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 191.29 E-value: 7.14e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 7 EGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEE 86
Cdd:cd13144 3 SGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 87 TKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNlKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFI 166
Cdd:cd13144 83 ANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFT-DDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 167 INTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLP 246
Cdd:cd13144 162 AQLIGAIINIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVGLP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 247 VSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISV 326
Cdd:cd13144 242 SIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 327 IGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIVFN-TLRIPGAL 405
Cdd:cd13144 322 IMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQlVVLLPLAW 401
|
410 420
....*....|....*....|....*
gi 543000758 406 LLSAGLGLSGVWWSISLSSIMKGII 430
Cdd:cd13144 402 LLAKMFGLNGVWWSFPIAEIVSFLL 426
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-386 |
1.22e-52 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 182.73 E-value: 1.22e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSY 90
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 91 IRHSLQLTVILALLYGATIFIFRRQFIGFFNlKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTI 170
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLG-HSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 171 GLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLK-GINFLQKPDWKHMRKIVRFGLPVSL 249
Cdd:cd13133 163 MVVVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRfGLRRAWRFDRELLRRILRLGLPSGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 250 QS----GAFTLIGMVIARIlsnwGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIIS 325
Cdd:cd13133 243 QFfldvGAFTVFFLLIGRL----GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLAL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 543000758 326 VIGLITSSLLVFLPGPIFSIFIREKD---VVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRT 386
Cdd:cd13133 319 AYMLLLGILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDT 382
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
20-364 |
1.01e-48 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 170.12 E-value: 1.01e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 20 PIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYIRHSLQLTV 99
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 100 ILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGLVIAITLD 179
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGE-VAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 180 PLLILGIgpFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLPVSLQSGAFTLIGM 259
Cdd:TIGR00797 160 YILIFGK--FGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 260 VIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVIGLITSSLLVFLP 339
Cdd:TIGR00797 238 LLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 543000758 340 GPIFSIFIREKDVVKEGIVYLRILG 364
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-385 |
3.51e-48 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 170.95 E-value: 3.51e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 4 NLTEGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTwFAFAFITIP-QIGAAVGIAQAVGKK 82
Cdd:cd13149 1 KLTEGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVV-LFLNSLTIGlGIGASAVISRAIGAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 83 DTEETKSYIRHSLQLTVILALLYGATIFIFRRQFigFFNL-KGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDS 161
Cdd:cd13149 80 DRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPL--FSLLgASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 162 KTPFIINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIV 241
Cdd:cd13149 158 KRPSLVMLGAALVNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 242 RFGLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTAL 321
Cdd:cd13149 238 SIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 543000758 322 GIISVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGR 385
Cdd:cd13149 318 KFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGK 381
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-388 |
3.74e-48 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 170.96 E-value: 3.74e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 4 NLTEGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKD 83
Cdd:cd13141 3 DLTQGSIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 84 TEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFfnLKGDD-IINNASSFLG--IISLGMVFFFLppVLTAIFNGHGD 160
Cdd:cd13141 83 QGEANAVFNQSLLLAAVLGLVVLVLGYLFGRLYLET--LAADAaTVEAATTYLYwfIPSLALQFILT--VLGAALRGTGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 161 SKTPFIINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKI 240
Cdd:cd13141 159 VKPFMVIQILAVLLNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRPDLPTWKRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 241 VRFGLPVslqSGAFTLIGMVIARI---LSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGY 317
Cdd:cd13141 239 LKIGLPS---GGEFLLTFVYMAVIywaLRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETF 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 543000758 318 FTALGIISVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVP 388
Cdd:cd13141 316 RITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWP 386
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-391 |
6.40e-44 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 159.21 E-value: 6.40e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 9 KILKKLIILALPIMGTSFIQMAYNLADMLWVG-ILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEET 87
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGhGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 88 KSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNlKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFII 167
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLG-ASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 168 NTIGLVIAITLDPLLILGIGpfprLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLPV 247
Cdd:cd13143 160 MLIGAVLNIILDPLFIFVLG----LGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 248 SLQSGAFTLIGMVIARILSNW-GPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISV 326
Cdd:cd13143 236 FLMQLSSSVVTIVLNLTLLGYgGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALI 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 543000758 327 IGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSL 391
Cdd:cd13143 316 YGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAAL 380
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
11-391 |
6.53e-44 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 159.59 E-value: 6.53e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAV--GTSGFFTWFAFAFITIpqigAAVG--IAQAVGKKDTEE 86
Cdd:cd13131 2 LRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAValGSSLWFPVFTFGMGLL----LAVTplVAQAHGAGDRRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 87 TKSYIRHSLQLTVILALLyGATIFIFRRQFIGFFNLKgDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFI 166
Cdd:cd13131 78 IRRAVRQGLWLALLLSLP-LMLLLWLAPPILPLMGQE-PEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 167 INTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINF--LQKPDWKHMRKIVRFG 244
Cdd:cd13131 156 ITLLALVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFarFWRPDWARLKELLRLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 245 LPVSLQ----SGAFTLIGMVIARIlsnwGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTA 320
Cdd:cd13131 236 LPIGLTiffeVSLFAAVALLMGRL----GTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVG 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 543000758 321 LGIISVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSL 391
Cdd:cd13131 312 LGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFL 382
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
12-442 |
7.02e-43 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 156.93 E-value: 7.02e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 12 KKLII-LALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGtsgFFTWFAFAFITIPQ---IGAAVGIAQAVGKKDTEET 87
Cdd:cd13147 8 KKAIIkLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIG---FVFPLFMIIIGLGNglgAGASSAISRRIGAKDKEGA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 88 KSYIRHSLQLTVILALLYGATIFIFRRQFigFFNLKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFII 167
Cdd:cd13147 85 DNAAVHSILLGLIISIILTIVLLPFLEPI--LVLMGAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 168 NTIGLVIAITLDPLLILGIGpfprLEVAGAAIATIFAQFVATSIYFFVIL-KKTNYLKGINFLQKPDWKHMRKIVRFGLP 246
Cdd:cd13147 163 MVAGSILNIILDPIFIYTLG----LGIAGAAWATVISMLISSLVLLYWFFvKKDTYVSLSLKNFKFDKKIVKDILKVGIP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 247 VSLQSGAFTLIGMVIARILSN-WGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIIS 325
Cdd:cd13147 239 ASLEQLIMSVLMIILNLILVIvAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 326 VIGLITSSLLVFLPGPIFSIFIREKD---VVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRtvppSLNGIVFNTLR-- 400
Cdd:cd13147 319 IIELIIAILIFIFAPQIAYLFTYSEEsahLAPEIVAFLRIMCLFLPFVPFGMMSSSMFQGIGK----GLTSLIITILRel 394
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 543000758 401 -----IPGALLLSAGLGLSGVWWSISLSSIMKGIILTSWFIIFLCRH 442
Cdd:cd13147 395 ifqvlFAYLFAIVLGLGLFGVWWGIVLGNAIGSIVGYLWARLYIKRL 441
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-435 |
3.73e-42 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 155.08 E-value: 3.73e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 2 NTNLTEGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGK 81
Cdd:cd13139 4 EQDFTSGSLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 82 KDTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDS 161
Cdd:cd13139 84 KDPEGAGFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPA-VIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 162 KTPFIINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIV 241
Cdd:cd13139 163 AIAMRSLWLANGLNIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLDWAIIKKII 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 242 RFGLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTAl 321
Cdd:cd13139 243 KIAVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRA- 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 322 GIISVIGLITSSLLVFLPG-PIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSL-NGIVFNTL 399
Cdd:cd13139 322 GKYNMVFLGIVSLVFFLFAePLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLiNLVGFWLF 401
|
410 420 430
....*....|....*....|....*....|....*...
gi 543000758 400 RIPG--ALLLSAGLGLSGVWWSISLSSIMKGIILTSWF 435
Cdd:cd13139 402 QIPLayLLARHLNLGPKGVFIAIPIAETVLAIAAIILF 439
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
4-362 |
8.82e-41 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 151.21 E-value: 8.82e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 4 NLTEGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSG--FFTWFAFAFitipQIGAAVG--IAQAV 79
Cdd:cd13145 1 DLTKGPIPKLIRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFpiFFIIIAIGV----GIGTGTTalIGNAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 80 GKKDTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHG 159
Cdd:cd13145 77 GAGDRRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGD-YLDLALEYMDVIFAGSIFFLLNFGLNGILNAQG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 160 DSKTPFIINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATsIYFFVILKKTNYLKGINF-LQKPDWKHMR 238
Cdd:cd13145 156 DTKSYRNFLIIGFFLNIILDPLFIFGGGGIPAMGVSGIALATIISQFIGM-FYLLYKVRKSGIISGCRLrDFIPRLDVYK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 239 KIVRFGLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYF 318
Cdd:cd13145 235 EILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYK 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 543000758 319 TALGIISVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRI 362
Cdd:cd13145 315 KALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRI 358
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-386 |
6.72e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 134.73 E-value: 6.72e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 12 KKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYI 91
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 92 RHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIG 171
Cdd:cd13135 81 ISSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQ-ILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 172 LVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILK--KTNYLKGINFLQKPDWKHMRKIVRFGLPVSL 249
Cdd:cd13135 160 NLLNVILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILVYLCRKikKLTFKLSNTKVLKANIRPYKFTIKLGLPLGG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 250 QSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVIGL 329
Cdd:cd13135 240 EEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYI 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 543000758 330 ITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRT 386
Cdd:cd13135 320 AAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDT 376
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-395 |
1.16e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 128.54 E-value: 1.16e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 5 LTEGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSgfftwFAFAFITIPQIGAAVG------IAQA 78
Cdd:cd13148 5 LLTAPILPTLLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALV-----FPLLMLTQMMSNGAMGggvssaIARA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 79 VGKKDTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGH 158
Cdd:cd13148 80 LGAGDRERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGE-ALDAALAYSNVLFSGAILIWLVNLLAAALRGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 159 GDSKTPFIINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMR 238
Cdd:cd13148 159 GNMRVPALVTLVGAVVQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLRALRLERRLFR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 239 KIVRFGLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYK--- 315
Cdd:cd13148 239 DILRVGLLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRiaw 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 316 -GYFTALGIISVIGLitssLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGI 394
Cdd:cd13148 319 tGALMAAVLAGAIGL----VLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLGLALYFASQGAGRMLWPVLAGT 394
|
.
gi 543000758 395 V 395
Cdd:cd13148 395 L 395
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
12-435 |
2.10e-28 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 116.12 E-value: 2.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 12 KKLIILALPIMGTSFIQMAYNLADMLWVGILGS-RAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSY 90
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSaAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 91 IRHSLqltvILALLYGATIFIFRRQFIGFF--NLKGDDIINN-ASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFII 167
Cdd:cd13136 83 LVRAL----LLALAIGLLLILLQSPLLALAllLLGASAAVAAlARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 168 NTIGLVIAITLDPLLILGIGpfprLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRFGLPV 247
Cdd:cd13136 159 QIVGNVVNIVLDPLFVFGLG----WGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 248 SLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVI 327
Cdd:cd13136 235 FIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 328 GLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIVFNTLRIPGALLL 407
Cdd:cd13136 315 GVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLL 394
|
410 420
....*....|....*....|....*...
gi 543000758 408 SAGLGLSGVWWSISLSSIMKGIILTSWF 435
Cdd:cd13136 395 VPLWGNHGLWLALILFMLLRGLTLALRL 422
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-388 |
2.73e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 113.27 E-value: 2.73e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 7 EGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIP---QIGAAVGIAQAVGKKD 83
Cdd:cd13146 3 SGPISPLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVGGIGLVFPLGMIFLALGngiQVGVSSLLARAIGAQR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 84 TEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDdIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKT 163
Cdd:cd13146 83 AKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGL-LLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 164 PFIINTIGLVIAITLDPLLILGIgpfpRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHMRKIVRF 243
Cdd:cd13146 162 MMMAMLIGTVVNIVLDPILIFVF----DMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISSSVIVEILRV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 244 GLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGI 323
Cdd:cd13146 238 GLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVIL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 543000758 324 ISVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVP 388
Cdd:cd13146 318 GIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWP 382
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
20-181 |
2.04e-21 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 90.70 E-value: 2.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 20 PIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYIRHSLQLTV 99
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 100 ILALLYGATIFIFRRQFIGFFNLKgDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGLVIAITLD 179
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQD-EEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 543000758 180 PL 181
Cdd:pfam01554 160 YL 161
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
11-385 |
9.23e-21 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 94.18 E-value: 9.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVG-TSGFFTWFAFAFITIpqIGAAVG--IAQAVGKKDteet 87
Cdd:cd13132 2 AKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASlASSFANVTGFSILLG--LASALDtlCGQAFGAKN---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 88 KSYIRHSLQLTVILALL----------YGATIFIFRRQfigffnlkGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNG 157
Cdd:cd13132 76 YKLVGVYLQRALVILLLccvpisllwlNTEPILLLLGQ--------DPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 158 HGDSKTPFIINTIGLVIAITLDPLLILGIGpfprLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINFLQKPDWKHM 237
Cdd:cd13132 148 QGIVLPLVYISLVALLLNILLNYLLVFVLG----LGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 238 RKIVRFGLP----VSLQSGAFTLIgMVIARILSnwGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRI 313
Cdd:cd13132 224 GPFLKLAIPsalmLCLEWWAFEIL-VLLAGLLP--GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRA 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 543000758 314 YKGYFTALGIISVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGR 385
Cdd:cd13132 301 KLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGR 372
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
11-382 |
8.73e-19 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 88.33 E-value: 8.73e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSR--AVTAVGTSGFFTWFAFA---FITIPQIgaavgIAQAVGKKDTE 85
Cdd:PRK01766 11 ARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATdlAAVAIGTSIWLPVILFGhglLLALTPI-----VAQLNGAGRRE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 86 ETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKgDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPF 165
Cdd:PRK01766 86 RIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLE-PEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 166 IINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIAT---IFAQFVAtsiyFFVILKKTNYLKGINFLQK---PDWKHMRK 239
Cdd:PRK01766 165 VIGFLGLLINIPLNYIFIYGKFGFPELGGVGCGVATaivYWVMFLA----MLIYIKRARRFRDFRLFKGlykPDWAVIKR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 240 IVRFGLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFT 319
Cdd:PRK01766 241 LLKLGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543000758 320 ALGIISVIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNG 382
Cdd:PRK01766 321 GLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRG 383
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
246-402 |
4.51e-18 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 81.07 E-value: 4.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 246 PVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIIS 325
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 543000758 326 VIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIVFNTLRIP 402
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIP 157
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
8-232 |
3.07e-16 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 80.98 E-value: 3.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 8 GKILKKLIILALPIMGTSFIQMAYNLADMLWVG----ILGSRAVTAVGTSGFFTWFAFAFITIPQ-IGAAVG------IA 76
Cdd:COG5841 229 KDILKELLRIAIPITLSSLVLPLFQLIDSFTVPrrlqAAGLSASEATSLYGILSGMAQPLVNLPTvLATALAtslvpaIS 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 77 QAVGKKDTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIG-FFNLkgddiiNNASSFLGIISLGMVFFFLPPVLTAIF 155
Cdd:COG5841 309 EAFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTlLFGN------PEGGGILAILAPSAIFLSLQQVTTGIL 382
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 543000758 156 NGHGDSKTPFIINTIGLVIAITLDPLLIlgigpfPRLEVAGAAIATIFAQFVATSIYFFVILKKTNY-LKGINFLQKP 232
Cdd:COG5841 383 QGLGKQKIPVINLLIGLLVKIILNYLLV------PLFGIYGAALATVIGYLVAAILNLAALKKYTGFkLDLRRRLLKP 454
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
8-222 |
2.45e-15 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 77.51 E-value: 2.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 8 GKILKKLIILALPIMGTSFIQMAYNLAD-MLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVG----------IA 76
Cdd:cd13124 220 KEILKELLSYAIPITLSSLILPLLQLIDsFTVPRRLQAAGLSESEATALYGILTGRAQPLVQLPTVIAtalstslvpaIS 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 77 QAVGKKDTEETKSYIRHSLQLTVILALLYGATIFIFRRQ-FIGFFNlkgddiINNASSFLGIISLGMVFFFLPPVLTAIF 155
Cdd:cd13124 300 EAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPiNTLLFG------DSEGGLILQILAPSILFLSLQQVTAAIL 373
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 543000758 156 NGHGDSKTPFIINTIGLVIAITLDPLLIlgigpfPRLEVAGAAIATIFAQFVATSIYFFVILKKTNY 222
Cdd:cd13124 374 QGLGKVKIPVINLLIGLLVKIVLNYVLI------PIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
11-276 |
7.97e-14 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 73.26 E-value: 7.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVgtsgfftWFAFAFITIPQ--IGAAVG------IAQAVGKK 82
Cdd:COG0728 221 VRRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSAL-------YYADRLYQLPLglFGVAIGtallprLSRAAAAG 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 83 DTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKG----DDIINNASSfLGIISLGMVFFFLPPVLTAIFNGH 158
Cdd:COG0728 294 DLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGaftaEDTALTALA-LAAYALGLPAFALVKVLARAFYAR 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 159 GDSKTPFIINTIGLVIAITLDPLLIlgigpfPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLkginflqkpdwkHMR 238
Cdd:COG0728 373 QDTRTPVRIAVIAVVVNIVLNLLLV------PPLGHAGLALATSLSALVNALLLLVLLRRRLGGL------------PLR 434
|
250 260 270
....*....|....*....|....*....|....*...
gi 543000758 239 KIVRFGLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQ 276
Cdd:COG0728 435 GILRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGR 472
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-219 |
8.46e-14 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 72.93 E-value: 8.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 9 KILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTS----GFFTWFAFAFitipQIGAAVGIAQAVGKKDT 84
Cdd:cd13137 223 KIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGlrieSLAFMPGFGF----SMAASTLVGQNLGAGDP 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 85 EETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNlKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTP 164
Cdd:cd13137 299 DEARRYGKRALRLGVLFMGLLGLLLFIFAPPLASLFT-PDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPP 377
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 543000758 165 FIINTIGLVIaITLDPLLILGIgpFPRLEVAGAAIATIFAQFVATSIYFFVILKK 219
Cdd:cd13137 378 LIINLISMWL-VRLPLAYLLGF--VLGLGLTGIWLAMFVDTIVRAILLLYRFRKG 429
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
59-386 |
3.21e-13 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 71.03 E-value: 3.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 59 FAFAFITIPQIGAAVGIAQA----VGKKDTEETKSYIRHSLQLTVILALLYGATIFIFRrqFIGFFNlkgddiINNASSF 134
Cdd:cd13128 40 LALAFVGLFSIFADLGLPTAlvreIARYRKEKIREIISTSLVLKLILGILALLLLFLFA--FLIAFY------DPELVLL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 135 LGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGLVIAITLDPLLIlgigpFPRLEVAGAAIATIFAQFVATSIYFF 214
Cdd:cd13128 112 LYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILV-----LLGGGLIGFALAYLIASVLSAILLLY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 215 VILKKtnylKGINFLQKPDWKHMRKIVRFGLPVSLqSGAFTLIGMVIARIL--SNWGPTPIAVQSVGSQIESLSWMTAGG 292
Cdd:cd13128 187 IYRKK----ILLPKFFSFDLKLAKELLRFSIPLAL-SGIFSLIYTRIDTIMlgYFLGDAAVGIYNAAYRIAELLLFIPSA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 293 FQTALAAFVGQNFgAKKWDRIYKGYFTALGIISVIGLITSSLLVFLPGPIFSIFIREKdvVKEGIVYLRILGVSQFFMCI 372
Cdd:cd13128 262 ISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE--YLPAALVLQILAWGFLFIFL 338
|
330
....*....|....
gi 543000758 373 EITTSGAFNGLGRT 386
Cdd:cd13128 339 NGIFGSILQAIGKQ 352
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
11-351 |
1.89e-10 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 62.84 E-value: 1.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFftwfAFAFITIPQIG--AAVG--IAQAVGKKDTEE 86
Cdd:PRK00187 9 LKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAA----SYSFVSIFCVGviAAVGtlVAIRHGAGDIEG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 87 TKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFnlKGDDIINNASSFLGIISLG----MVFFFLPPVLTAIfnghGDSK 162
Cdd:PRK00187 85 ATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFG--QAPQNVDAAMQFLHLLPFAlpgyLSFMALRGFTSAL----GRAG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 163 TPFIINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIAT-IFAQFVATSIYFFVILKKTNYLKGI-NFLQKPDWKHMRKI 240
Cdd:PRK00187 159 PVMVISLAGAVANLLLNYALIEGWFGLPKLGLMGIGLVTaLVSNGMALALALYIRRHPAYAAYPLrKGLSRPSRAALREL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 241 VRFGLPV----SLQSGAFTligmVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKG 316
Cdd:PRK00187 239 WRLGLPIggtyAVEVGLFT----FAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRA 314
|
330 340 350
....*....|....*....|....*....|....*
gi 543000758 317 YFTALGIISVIGLITSSLLVFLPGPIFSIFIREKD 351
Cdd:PRK00187 315 GRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLDRND 349
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
9-216 |
1.54e-09 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 59.48 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 9 KILKKLIILALPIMGTSFIQMAYNLADMLWVG-ILGSRAVtavgtsGFFTwFAFAFITIPQIGAAVgIAQAV-------G 80
Cdd:cd13128 203 KLAKELLRFSIPLALSGIFSLIYTRIDTIMLGyFLGDAAV------GIYN-AAYRIAELLLFIPSA-ISTALfpriselY 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 81 KKDTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFnlKGDDIINnASSFLGIISLGMVFFFLPPVLTAIFNGHGD 160
Cdd:cd13128 275 KNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLL--FGEEYLP-AALVLQILAWGFLFIFLNGIFGSILQAIGK 351
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 543000758 161 SKTPFIINTIGLVIAITLDPLLIlgigpfPRLEVAGAAIATIFAQFVATSIYFFVI 216
Cdd:cd13128 352 QKLTLKILLIGALLNVILNLLLI------PKYGIIGAAIATLISEFIIFILLLYLL 401
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-218 |
1.54e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 59.78 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 9 KILKKLIILALPIM-GTSFIQMAyNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEET 87
Cdd:cd13138 222 EILKEILKIGLPSAlQQSLVSIS-FLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERA 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 88 KSYIRHSLQLTVILALLYGATIFIFRRQFIGFFnLKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFII 167
Cdd:cd13138 301 KKGLRTGIIISLIIGLIIILLVFFFAPQLLGLF-TSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMII 379
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 543000758 168 NTIGLVIAITldpLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILK 218
Cdd:cd13138 380 SILRLWLVRI---PLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRK 427
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
75-392 |
1.80e-09 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 59.40 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 75 IAQAVGKKDTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFnlkgddiINNASSFLGIISLGMVFFFLPP--VLT 152
Cdd:cd13124 59 VAEYNALGDYKGARRIFRVSLILLLILGLVFFLLLFFGAPFLAQLL-------LGDPRLAPVIRALAPAILIVPLlsVLR 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 153 AIFNGHGDSkTPF----IINTIGLVIAITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTNYLKGINF 228
Cdd:cd13124 132 GYFQGLQNM-TPTavsqVIEQIVRVIVILVLAYLLLPVGGGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLR 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 229 LQKPDWKH----MRKIVRFGLPVSLQSGAFTLIGMV----IARILSNWGPTPIAVQSVGSQIESLSW---MTAGGFQTAL 297
Cdd:cd13124 211 KSPRSKIStkeiLKELLSYAIPITLSSLILPLLQLIdsftVPRRLQAAGLSESEATALYGILTGRAQplvQLPTVIATAL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 298 AA----FVGQNFGAKKWDRIYKGYFTALGIISVIGLITSSLLVFLPGPIFSIFIREKdvvkEGIVYLRILGVSQFFMCIE 373
Cdd:cd13124 291 STslvpAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS----EGGLILQILAPSILFLSLQ 366
|
330
....*....|....*....
gi 543000758 374 ITTSGAFNGLGRTVPPSLN 392
Cdd:cd13124 367 QVTAAILQGLGKVKIPVIN 385
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
11-219 |
2.00e-09 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 59.39 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVgtsgfftWFAFAFITIPQ--IGAAVG------IAQAVGKK 82
Cdd:cd13123 214 VRRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISAL-------YYADRLYQLPLgiFGVAIAtallprLSRLAAAG 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 83 DTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKG----DDIINNASSfLGIISLGMVFFFLPPVLTAIFNGH 158
Cdd:cd13123 287 DLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERGaftaEDTLMTASA-LAAYALGLPAFALVKLLSRAFYAL 365
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 543000758 159 GDSKTPFIINTIGLVIAITLDPLLIlgigpfPRLEVAGAAIATIFAQFVATSIYFFVILKK 219
Cdd:cd13123 366 KDTKTPVKIAVIAVAVNILLNLLLI------KPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
63-296 |
2.05e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 59.09 E-value: 2.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 63 FITIPQIGAAVGIAQAVGK------KDTEETKSYIRHSLQLTVILALLYGATIFIFRrQFIGFFNLKGDDiinnASSFLG 136
Cdd:cd13125 42 FVTILQTIAGGGINNGVVKytaeykDDEEKLARVWSTAFRITLILSILGGLLLLLFS-KPLSSLLFGDID----YSWVFI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 137 IISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGLVIAITLDPLLILGIGpfprleVAGAAIATIFAQFVATsIYFFVI 216
Cdd:cd13125 117 LLGLALPLFALNNLLLAILNGLKEIKRYALINIISSLIGLLVSVLLVYFYG------LKGALLALVLNQSLIF-LVTLIY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 217 LKKTNYLKGINFLQKPDWKHMRKIVRFGLpVSLQSGAFTLIGMVIARILSnwgptpiavqsvgsqIESLSWMTAGGFQTA 296
Cdd:cd13125 190 SRKQPWFKLKYLWGRLDKDIIKKLLKFSL-MALVSALSLPLSQIIVRNIL---------------IRQLGWEAAGYWQAV 253
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
14-213 |
6.81e-09 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 57.27 E-value: 6.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 14 LIILALPIMGTSFIQMAYNLADMLWVG-ILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYIR 92
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGaLLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 93 HSLQLTVILALLYGATIFIFRRQFIGFFnlkGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGL 172
Cdd:COG2244 255 KALRLLLLLGLPLALGLALLAPPLLSLL---FGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGA 331
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 543000758 173 VIAITLDPLLIlgigpfPRLEVAGAAIATIFAQFVATSIYF 213
Cdd:COG2244 332 VLNLVLNLLLI------PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-213 |
5.89e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 54.84 E-value: 5.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 7 EGKILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAvgTSGFFTWFAFAFITIPQIGAAVGI--AQAVGKKDT 84
Cdd:cd13133 226 DRELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAA--TNIVFSINSLAFLPMIGLGIAVSSlvGQALGAGRP 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 85 EETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGD--DIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSK 162
Cdd:cd13133 304 DLAMRVTRRGLKLALAYMLLLGILFLLFPELLLSIFTPGADfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTR 383
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 543000758 163 TPFIINTIGLVIAitLDPLLILGIGPFPRLEVA-GAAIATIFAQFVATSIYF 213
Cdd:cd13133 384 FVMLAELIVAWLY--LLPPAYLLVVLGAGLAGAwTVETVYVIVLALIFLLRF 433
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
47-402 |
6.20e-08 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 54.57 E-value: 6.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 47 VTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNlkgdd 126
Cdd:COG2244 35 PEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRRLLSTALLLRLLLSLLLALLLLLLAPFIAALLG----- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 127 iINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGLVIAITLdpllilgigpfprlevagaAIATIFAQF 206
Cdd:COG2244 110 -EPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLL-------------------ALLLALLGL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 207 VATSIyffvilkktnylkginflqkpdwkhmrkIVRFGLPVSLQSGAFTLIGMVIARILSNW-GPTPIAVQSVGSQIESL 285
Cdd:COG2244 170 GLWGL----------------------------VLKYSLPLLLSGLLGLLLTNLDRLLLGALlGPAAVGIYSAAYRLASL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 286 SWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIISVIGLITSSLLVFLPGPIFSIFIREKDVvkEGIVYLRILGV 365
Cdd:COG2244 222 LLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYA--EAAPVLPILAL 299
|
330 340 350
....*....|....*....|....*....|....*..
gi 543000758 366 SQFFMCIEITTSGAFNGLGRTVPPSLNGIVFNTLRIP 402
Cdd:COG2244 300 GALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLV 336
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
246-402 |
8.70e-08 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 53.79 E-value: 8.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 246 PVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYKGYFTALGIIS 325
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 543000758 326 VIGLITSSLLVFLPGPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPPSLNGIVFNTLRIP 402
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINII 157
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
12-308 |
1.17e-07 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 53.97 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 12 KKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAV---TAVGTSGffTWFAFAFITIPQIGAAVGIAQAVGKKDteetK 88
Cdd:PRK10367 9 KALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYlggVAVGATA--TSFLFMLLLFLRMSTTGLTAQAFGAKN----P 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 89 SYIRHSLQLTVILALLYGATIFIFRRQFIGF-FNLKGDD--IINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPF 165
Cdd:PRK10367 83 QALARALVQPLLLALGAGALIALLRTPLIDLaLHIVGGSeaVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 166 IINTIGLVIAITLDPLLILGIGpfprLEVAGAAIATIFAQFvATSIYFFVILKKTNYLKGINF-LQKPDWK-HMRKIVRF 243
Cdd:PRK10367 163 ILLVVGNILNIVLDLWLVMGLH----MNVQGAALATVIAEY-ATLLIGLLMVRKVLKLRGISLeMLKTAWRgNFRRLLAL 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 543000758 244 GLPVSLQS-------GAFTLIGmviARIlsnwGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAK 308
Cdd:PRK10367 238 NRDIMLRSlllqlcfGAITVLG---ARL----GSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGAR 302
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
17-285 |
1.45e-07 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 53.59 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 17 LALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTEETKSYIRHSLQ 96
Cdd:PRK10189 34 LAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 97 LTVILALLYGATIFIFRRQFIGFFNLKGDDIINN-ASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGLVIA 175
Cdd:PRK10189 114 IMTLFAVLLAVLIHFFGEQIIDLVAGDATPEVKAlALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGGMNILN 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 176 ITLDPLLILGIGPFPRLEVAGAAIATIFAQFVATSIYFFVILKKTN---------YLKGINFlqkpdwKHMRKIVRFGLP 246
Cdd:PRK10189 194 IIISSILIYGLFSWQGLGFVGAGLGLTISRYIGAVAIIWVLMIGFNpalrislksYFKPLNF------AIIWEVMGIGIP 267
|
250 260 270
....*....|....*....|....*....|....*....
gi 543000758 247 VSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESL 285
Cdd:PRK10189 268 ASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAAL 306
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-172 |
3.73e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 52.12 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 9 KILKKLIILALPIMGTsfiQMAYNLADML---WVGILGSRAVTAVGTSGFFTWFAFAFITIPQIGAAVGIAQAVGKKDTE 85
Cdd:cd13134 225 KLLKKILKIGLPSAGE---ELSYNLSQTVitaFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFD 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 86 ETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKgDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPF 165
Cdd:cd13134 302 EAYKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDD-PEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPV 380
|
....*..
gi 543000758 166 IINTIGL 172
Cdd:cd13134 381 LIGIISM 387
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
9-171 |
3.92e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 52.12 E-value: 3.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 9 KILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFafiTIPQ-IGAAVGIA--QAVGKKDTE 85
Cdd:cd13131 226 ARLKELLRLGLPIGLTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLF---MVPLgISMAATVRvgFALGAGDPA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 86 ETKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNlKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPF 165
Cdd:cd13131 303 DARRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYT-NDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPF 381
|
....*.
gi 543000758 166 IINTIG 171
Cdd:cd13131 382 LLALIS 387
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
70-346 |
5.23e-07 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 51.92 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 70 GAAVGIAQavGKKDTEETKSYIRHSLQLTVILALLYGATIFIFRRQFIgffNLKG--DDIINNASSFLGIISLGMVFFFL 147
Cdd:PRK09575 73 GSLLSIKR--GEGDLEKAKRILTTGLLLLLLLGPIVSVILFLFADDFL---RAQGaeGRTLELALQYIQVLIWGCLFTLG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 148 PPVLTAIFNGHGDSKTPFIINTIGLVIAITLDPLLILGIGpfprLEVAGAAIATIFAQFVATSI---YFFVilKKTNYLK 224
Cdd:PRK09575 148 AIALPFLLRNDESPNLATGLMVIGALINIVLDYLFIGWLD----WGLTGAAIATALAQLVVTVLglgYFFS--SRANIRL 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 225 GINFLQKpDWKHMRKIVRFGLPvSLQSGAFTliGMVIA---RILSNWG-PTPIAVQSVGSQIESLSWMTAGGFQTALAAF 300
Cdd:PRK09575 222 TLKELRF-NWSLAPKIVLLGSS-SFFMYLYG--SFVVAlhnRLFMEYGsALTVGAYAIVGYLMVLYYLVAEGIAEGMQPP 297
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 543000758 301 VGQNFGAKKWDRIYKGYFTALGIISVIGLITSSLLVFLPGPIFSIF 346
Cdd:PRK09575 298 VSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLLNLFPETMIALF 343
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
135-232 |
3.39e-06 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 46.41 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 135 LGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIINTIGLVIAITLDPLLIlgigpfPRLEVAGAAIATIFAQFVATSIYFF 214
Cdd:pfam14667 2 LQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLI------PLFGIVGAAIATVISLLVVALLNLY 75
|
90
....*....|....*...
gi 543000758 215 VILKKTNYLKGINFLQKP 232
Cdd:pfam14667 76 YLRRYLGLRLLLRRLLKP 93
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
236-397 |
7.10e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 48.26 E-value: 7.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 236 HMRKIVRFGLPVSLQSGAFTLIGMVIARILSNWGPTPIAVQSVGSQIESLSWMTAGGFQTALAAFVGQNFGAKKWDRIYK 315
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 316 GYFTALGIISVIGLITSSLLVFLPgPIFSIFIREKDVVKEGIVYLRILGVSQFFMCIEITTSGAFNGLGRTVPP---SLN 392
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLLLWLAP-PILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAmviTLL 159
|
....*
gi 543000758 393 GIVFN 397
Cdd:cd13131 160 ALVLN 164
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
11-219 |
1.40e-04 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 44.20 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIpQIGAAV--GIAQAVGKKDTEETK 88
Cdd:pfam03023 196 LKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYADRIYQLPLGIFGV-SISTVLlpRLSRHAADGDWDEFR 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 89 SYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDDIIN---NASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPF 165
Cdd:pfam03023 275 DLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFSPEdvtATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPF 354
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 543000758 166 IINTIGLVIAITLDPLLIlgigpfPRLEVAGAAIATIFAqFVATSIYFFVILKK 219
Cdd:pfam03023 355 KISLISAVLNILLSLLLL------PPLGVAGLALATSLS-SLIGLVFLYYILRK 401
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
11-219 |
1.69e-03 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 40.77 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSGFFTWFAFAFITIpQIGAAV--GIAQAVGKKDTEETK 88
Cdd:TIGR01695 222 LKRFLKLFLPTTLGSSASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIFGI-SLSTVLlpKLSRHASEGNWNELR 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 89 SYIRHSLQLTVILALLYGATIFIFRRQFIGFFNLKGDDIINNA---SSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPF 165
Cdd:TIGR01695 301 DLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGAFSEEDTvmtATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPF 380
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 543000758 166 IINTIGLVIAITLDPLLIlgigpfPRLEVAGAAIATIFAQFVATSIYFFVILKK 219
Cdd:TIGR01695 381 INSVISVVLNALLSLLLI------FPLGLVGIALATSAASMVSSVLLYLMLNRR 428
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-218 |
1.86e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 40.35 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 11 LKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVgtSGFFTWFAFAFITIPQIGAAVG--IAQAVGKKDTEETK 88
Cdd:cd13135 227 YKFTIKLGLPLGGEEFLWNIGNLAVIRILNRIGELALGIY--TLVFGIENIVLMPMYGYSSAALtlVGESIGKKDLKEAL 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 89 SYIRHSLQLTVILALLYGATIFIFRRQFIGFFNlKGDDIINNASSFLGIISLGMVFFFLPPVLTAIFNGHGDSKTPFIIN 168
Cdd:cd13135 305 RIGNICLGLGLLIYIAAAIVFLAFPYKILSLFT-NDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQ 383
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 543000758 169 TIGLVIAITLDPLLILGIGpfprLEVAGAAIATIFAQFVATSIYFFVILK 218
Cdd:cd13135 384 IIGTIIVVSVALLLIFVFK----LGLAGVYITLFIDEIIRAIINFLKYRK 429
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
9-139 |
2.63e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 39.92 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543000758 9 KILKKLIILALPIMGTSFIQMAYNLADMLWVGILGSRAVTAVGTSgfFTWFAFAFITIPQIGAAVGI--AQAVGKKDTEE 86
Cdd:TIGR00797 213 EVLKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIA--LNVESLLFMPAFGFGIAVSIlvGQALGAGDPKR 290
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 543000758 87 TKSYIRHSLQLTVILALLYGATIFIFRRQFIGFFNlKGDDIINNASSFLGIIS 139
Cdd:TIGR00797 291 AKEVARVALKLSLLLGLVLAIILILFREFIARLFT-NDPEVLELAAIYLIFVA 342
|
|
| |
