|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
12-352 |
2.15e-65 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 212.49 E-value: 2.15e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 12 ARLDFDRPIGLFSSLKMELSVLIVIATSIAFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAM 91
Cdd:COG5002 46 LLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 92 SEGDYSVRVHVATNSNDEIGQLARTFNEMAEELQHADQMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPAN---L 168
Cdd:COG5002 126 LLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERreyL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 169 EGILGQTHRLSDLIAFLLDLSRMEAGAASLNIERFCLHDFLDETIEPLEIADAGHAHDIMLHVDSD-IWMEGDQDRLRQL 247
Cdd:COG5002 206 EIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLGDPDRLEQV 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 248 FTNIIANALKHSADGTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIARWAAQ 327
Cdd:COG5002 286 LTNLLDNAIKYTPEGGTITVSLREEDDQVRIS--VRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVE 363
|
330 340
....*....|....*....|....*.
gi 542988465 328 LHGGTVRVVDDP-RGADFEIVLPKYH 352
Cdd:COG5002 364 AHGGRIWVESEPgKGTTFTITLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
29-350 |
1.51e-63 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 205.53 E-value: 1.51e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 29 ELSVLIVIATSIAFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVATNSND 108
Cdd:COG0642 8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 109 EIGQLARTFNEMAEELQHADQMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPANLEGILGQTHRLSDLIAFLLDL 188
Cdd:COG0642 88 LLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLINDLLDL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 189 SRMEAGAASLNIERFCLHDFLDETIEPLEIADAGHAHDIMLHVDSDI-WMEGDQDRLRQLFTNIIANALKHSADGTSVLI 267
Cdd:COG0642 168 SRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 268 EARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVkgRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEI 346
Cdd:COG0642 248 SVRREGDRVRIS--VEDTGPGIPPEDLERIFEPFF--RTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPgKGTTFTV 323
|
....
gi 542988465 347 VLPK 350
Cdd:COG0642 324 TLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
118-350 |
6.09e-63 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 200.90 E-value: 6.09e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 118 NEMAEELQHADQMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPA---NLEGILGQTHRLSDLIAFLLDLSRMEAG 194
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEErreLLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 195 AASLNIERFCLHDFLDETIEPLEIADAGHAHDIMLHVDSD-IWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEARENA 273
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542988465 274 DTGTIVtnVVNFGSQIPVEERSDIFRRFVkgRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLPK 350
Cdd:COG2205 163 DGVRIS--VSDNGPGIPEEELERIFERFY--RGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPgGGTTFTVTLPL 236
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
56-357 |
6.70e-51 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 176.36 E-value: 6.70e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 56 WIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVhvATNSNDEIGQLARTFNEMAEELQHADQMRRDVV 135
Cdd:PRK10549 167 WLIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRV--TPTSRDELGRLAQDFNQLASTLEKNEQMRRDFM 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 136 ANVSHELRTPVSALQAMVENMADGVVEPTPANLEGILGQTHRLSDLIAFLLDLSRMEAGA-----ASLNIerfclhdfld 210
Cdd:PRK10549 245 ADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGAlayrkTPVDL---------- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 211 etIEPLEIADAG-----HAHDIMLHVD--SDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEARENADtgtivTNVV 283
Cdd:PRK10549 315 --VPLLEVAGGAfrerfASRGLTLQLSlpDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDK-----TLRL 387
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542988465 284 NFGSQIP---VEERSDIFRRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDPRGA-DFEIVLPKYHIADDE 357
Cdd:PRK10549 388 TFADSAPgvsDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGvSITVELPLERDLQRE 465
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
56-341 |
9.66e-49 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 170.39 E-value: 9.66e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 56 WIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLARTFNEMAEELQHADQMRRDVV 135
Cdd:NF012163 167 WLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTP--TSNDELGKLAQDFNQLASTLEKNEQMRRDFM 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 136 ANVSHELRTPVSALQAMVENMADGVVEPTPANLEGILGQTHRLSDLIAFLLDLSRMEAGAASLNIERFCLHDFLDETIEP 215
Cdd:NF012163 245 ADISHELRTPLAVLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGA 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 216 LEIADAGHAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEARENADTGTIVTNVVNFGsqIPVEERS 295
Cdd:NF012163 325 FRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPG--VSDEQLA 402
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 542988465 296 DIFRRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDPRG 341
Cdd:NF012163 403 RLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLG 448
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
123-348 |
9.28e-44 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 154.29 E-value: 9.28e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 123 ELQHADQMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPAN---LEGILGQTHRLSDLIAFLLDLSRMEAGAASLN 199
Cdd:TIGR02966 106 RLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWnraLEIMLEQSQRMQSLVEDLLTLSRLESAASPLE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 200 IERFCLHDFLDETIEPLEIADAGHAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEAREnaDTGTIV 279
Cdd:TIGR02966 186 DEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRR--DGGGAE 263
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 542988465 280 TNVVNFGSQIPVEERSDIFRRFV---KGRSgpgTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVL 348
Cdd:TIGR02966 264 FSVTDTGIGIAPEHLPRLTERFYrvdKSRS---RDTGGTGLGLAIVKHVLSRHHARLEIESELgKGSTFSFIF 333
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
57-335 |
1.96e-39 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 147.59 E-value: 1.96e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 57 IAMPLTMIvaLGItyFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVAtnSNDEIGQLARTFNEMAEELQHA--------- 127
Cdd:NF033092 185 IALVITAV--LGI--LLARTITRPIKEMRKQALAMAKGDFSRKVKVY--GNDEIGQLAEAFNNLTKRLQEAqatteserr 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 --------------------------------------------------------------------------------
Cdd:NF033092 259 kldsvlshmtdgviatdrrgrvilindpalemlnvsretvlgqsildvlgleeeytlrdlleeqdsllldfsteeeplil 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 128 ------------------------------DQMRRDVVANVSHELRTPVSALQAMVENMADGVVE-PTPAN--LEGILGQ 174
Cdd:NF033092 339 ranfsviqresgfingliavlhdvteqekiEQERREFVANVSHELRTPLTTMRSYLEALADGAWKdPELAPrfLGVTQNE 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 175 THRLSDLIAFLLDLSRMEAGAASLNIERFCLHDFLDETIEPLEIADAGHAHDIMLHV-DSDIWMEGDQDRLRQLFTNIIA 253
Cdd:NF033092 419 TERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREFpKRDLWVEIDTDKITQVLDNIIS 498
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 254 NALKHSADGTSVLIEARENAdtGTIVTNVVNFGSQIPVEERSDIFRRF--V-KGRSgpgTESGGTGIGLSIARWAAQLHG 330
Cdd:NF033092 499 NAIKYSPEGGTITFRLLETH--NRIIISISDQGLGIPKKDLDKIFDRFyrVdKARS---RKMGGTGLGLAIAKEVVEAHG 573
|
....*
gi 542988465 331 GTVRV 335
Cdd:NF033092 574 GRIWA 578
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
36-350 |
1.14e-38 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 142.79 E-value: 1.14e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 36 IATSIAFVLVWFLLkygwsgwiampLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLAR 115
Cdd:COG5000 3 LQILFLLLLLLIAL-----------LLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPV--TGDDEIGELAR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 116 TFNEMAEEL----QHADQMRR----------------------------------------------------------- 132
Cdd:COG5000 70 AFNRMTDQLkeqrEELEERRRyletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellr 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 133 -----------------------------------------------------DVVANVSHELRTPVSALQAMVENMADG 159
Cdd:COG5000 150 ealergwqeeieltrdgrrtllvrasplrddgyvivfdditellraerlaawgELARRIAHEIKNPLTPIQLSAERLRRK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 160 VVEPTPAN-------LEGILGQTHRLSDLIAFLLDLSRMEAgaasLNIERFCLHDFLDETIEPLEIADAGHAHDIMLHVD 232
Cdd:COG5000 230 LADKLEEDredleraLDTIIRQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDLD 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 233 SDI-WMEGDQDRLRQLFTNIIANALKHSADGTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKgrsgpgTE 311
Cdd:COG5000 306 PDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIE--VSDNGPGIPEEVLERIFEPFFT------TK 377
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 542988465 312 SGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLPK 350
Cdd:COG5000 378 PKGTGLGLAIVKKIVEEHGGTIELESRPgGGTTFTIRLPL 417
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
61-350 |
1.05e-35 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 136.31 E-value: 1.05e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 61 LTMIVALG-ITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLARTFNEMAEELQHA-------DQMRR 132
Cdd:NF040691 195 LALVVLLGlIAWLVTRQVVAPVRSAARTAERFAAGDLSERMPV--KGEDDLARLARSFNQMADSLQRQirqleelSRLQQ 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 133 DVVANVSHELRTPVSALQAMVENMADGVVEPTPA---NLEGILGQTHRLSDLIAFLLDLSRMEAGAASLNIERFCLHDFL 209
Cdd:NF040691 273 RFVSDVSHELRTPLTTIRMAADVIHDSRDDFDPAtarSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLV 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 210 DETIEPLE--IADAGhahdIMLHVD---SDIWMEGDQDRLRQLFTNIIANALKHsADGTSVLIEARENADTGTIVtnVVN 284
Cdd:NF040691 353 RRVVDALRqlAERAG----VELRVDapgTPVVAEVDPRRVERVLRNLVVNAIEH-GEGKPVVVTVAQDDTAVAVT--VRD 425
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 542988465 285 FGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLPK 350
Cdd:NF040691 426 HGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPgQGSQFRLTLPR 492
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
32-349 |
1.06e-35 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 135.21 E-value: 1.06e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 32 VLIVIATSIAFVLVwFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVaTNSNDEIG 111
Cdd:TIGR01386 144 VQITVALDINAHTH-LLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDP-SRAPAELR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 112 QLARTFNEMAEELQHADQMRRDVVANVSHELRTPVSAL--QAMVENMADGVVEPTPANLEGILGQTHRLSDLIAFLLDLS 189
Cdd:TIGR01386 222 ELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLlgQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLA 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 190 RMEAGAASLNIERFCLHDFLDETIEPLE-IADaghAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIE 268
Cdd:TIGR01386 302 RADNGQLALERVRLDLAAELAKVAEYFEpLAE---ERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVR 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 269 ARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDPRGADFEIVL 348
Cdd:TIGR01386 379 IERRSDEVRVS--VSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRF 456
|
.
gi 542988465 349 P 349
Cdd:TIGR01386 457 P 457
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
53-350 |
2.49e-33 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 129.19 E-value: 2.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 53 WSGWIAMPLTMIVALGITYFFSRgliaPLRQLRDAAEAMSEGDysvRVHVATNSNDEIGQLARTFNEMAEEL---QHADQ 129
Cdd:PRK11100 186 WAGALLLGIALLIGAGVVWWLNR----SIRRLTRYADAVTEGK---PVPLPKLGSSELRELAQALESMRVKLegkAYVEQ 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 130 mrrdVVANVSHELRTPVSALQAMVENMADgvvEPTPAN----LEGILGQTHRLSDLIAFLLDLSRMEAGAASLNIERFCL 205
Cdd:PRK11100 259 ----YVQTLTHELKSPLAAIRGAAELLQE---DPPPEDrarfTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVAL 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 206 HDFLDETIEPLEIADAGHAHDIMLHVDsDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEARENADTGTIVtnVVNF 285
Cdd:PRK11100 332 AALLEELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALS--VEDQ 408
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542988465 286 GSQIPVEERSDIFRRFVkgrSGPGTESG--GTGIGLSIARWAAQLHGGTVRVVD-DPRGADFEIVLPK 350
Cdd:PRK11100 409 GPGIPDYALPRIFERFY---SLPRPANGrkSTGLGLAFVREVARLHGGEVTLRNrPEGGVLATLTLPR 473
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
61-349 |
4.45e-32 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 127.55 E-value: 4.45e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 61 LTMIVALGITYFFSRGLIAPLRQLRDAAEAM--SEGDYSVRVhVATNSNDEIGQLARTFNEMAEELQHADQMRRDVVANV 138
Cdd:TIGR03785 414 AIMSIGTLALFGFASWISWRIRRLSDDAEAAidSQGRISGAI-PASRSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRL 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 139 SHELRTPVSALQAMVENMADGVVEPTPAN-LEGILGQTHRLSDLIAFLLDLSRMEAGAASLNIERFCLHDFLDETIEPLE 217
Cdd:TIGR03785 493 SHELRTPVAVVRSSLENLELQALEQEKQKyLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQGYQ 572
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 218 IADAGhaHDIMLHVD-SDIWMEGDQDRLRQLFTNIIANALKHSADGTsvLIEARENADTGTIVTNVVNFGSQIPVEERSD 296
Cdd:TIGR03785 573 MTYPP--QRFELNIPeTPLVMRGSPELIAQMLDKLVDNAREFSPEDG--LIEVGLSQNKSHALLTVSNEGPPLPEDMGEQ 648
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 542988465 297 IFRRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDPR--GADFEIVLP 349
Cdd:TIGR03785 649 LFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQndGVVFRISLP 703
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
64-350 |
6.27e-32 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 123.18 E-value: 6.27e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 64 IVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVATNSNDEIGQLARTFNEMAEELQHADQMRRDVVANVSHELR 143
Cdd:NF012226 71 VISLIIGMKLAQRFIVPINFLADAAKKISQGDLSARAEDSQIHSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELR 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 144 TPVSALQAMVENMADGVVEPTPANLEGILGQTHRLSDLIAFLLDLSRMEAGAASLNIERFCLHDFLDETIEPLE--IADA 221
Cdd:NF012226 151 TPITILQGRLQGILDGVFEPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEdrLEQA 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 222 GhahdimLHVDSDI---WMEGDQDRLRQLFTNIIANALKHSADGTsVLIEARENADTGTIvtNVVNFGSQIPVEERSDIF 298
Cdd:NF012226 231 Q------LTIVLNLtatPVFCDRRRIEQVLIALIDNAIRYANAGK-LKISSSVIQDDWIL--QIEDEGPGIAEEYQQDLF 301
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 542988465 299 RRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDPRGADFEIVLPK 350
Cdd:NF012226 302 NPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVFTIKLPA 353
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
29-350 |
2.99e-29 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 117.96 E-value: 2.99e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 29 ELSVLIVIATSIAFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVATNSND 108
Cdd:COG4251 180 LLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 109 EIGQLARTFNEMAEELQHADQMRRDVVANVSHELRTP----VSALQAMVENMADGVVEPTPANLEGILGQTHRLSDLIAF 184
Cdd:COG4251 260 ELEELEEELEERTAELERSNEELEQFAYVASHDLREPlrkiSGFSQLLEEDYGDKLDEEGREYLERIRDAAERMQALIDD 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 185 LLDLSRMeaGAASLNIERFCLHDFLDETIEPLEIADAghAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADGTS 264
Cdd:COG4251 340 LLAYSRV--GRQELEFEPVDLNELLEEVLEDLEPRIE--ERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEP 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 265 VLIE--ARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVkgRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RG 341
Cdd:COG4251 416 PRIEigAEREGGEWVFS--VRDNGIGIDPEYAEKIFEIFQ--RLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPgEG 491
|
....*....
gi 542988465 342 ADFEIVLPK 350
Cdd:COG4251 492 ATFYFTLPK 500
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
7-349 |
6.07e-27 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 109.50 E-value: 6.07e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 7 RDRKQARLDFDRPIGLFSSLKMELSVLIVIATSIAFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRD 86
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 87 AAEAMSEGDYSVRVHVATNSNDEIGQLARTFNEMAEELQHADQMRRD----------------VVANVSHELRTPVSALQ 150
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRElqeqlvqseklaalgeLAAGIAHEINNPLAAIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 151 AMVENMADGV-----VEPTPANLEGILGQTHRLSDLIAFLLDLSRmeagAASLNIERFCLHDFLDETIEPLEIADAGHAH 225
Cdd:COG4191 162 GNAELLRRRLedepdPEELREALERILEGAERAAEIVRSLRAFSR----RDEEEREPVDLNELIDEALELLRPRLKARGI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 226 DIMLHVDSDIWM-EGDQDRLRQLFTNIIAN---ALKHSADGTsVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRF 301
Cdd:COG4191 238 EVELDLPPDLPPvLGDPGQLEQVLLNLLINaidAMEEGEGGR-ITISTRREGDYVVIS--VRDNGPGIPPEVLERIFEPF 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 542988465 302 V--KGrsgpgtESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:COG4191 315 FttKP------VGKGTGLGLSISYGIVEKHGGRIEVESEPgGGTTFTITLP 359
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
130-354 |
1.74e-25 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 106.63 E-value: 1.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 130 MRRDVVANVSHELRTPVSALQAMVENMADGVVEpTPANlEGILG----QTHRLSDLIAFLLDLSRMEAGAASLnierfcL 205
Cdd:PRK11006 203 ARRNFFANVSHELRTPLTVLQGYLEMMQDQPLE-GALR-EKALHtmreQTQRMEGLVKQLLTLSKIEAAPTID------L 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 206 HDFLD-----ETIEPLEIADAGHAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEARENAdTGTIVT 280
Cdd:PRK11006 275 NEKVDvpmmlRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVP-QGAEFS 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 281 nVVNFGSQIPVE------ERsdiFRRFVKGRSgpgTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLPKYHI 353
Cdd:PRK11006 354 -VEDNGPGIAPEhiprltER---FYRVDKARS---RQTGGSGLGLAIVKHALSHHDSRLEIESEVgKGTRFSFVLPERLI 426
|
.
gi 542988465 354 A 354
Cdd:PRK11006 427 A 427
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
56-352 |
2.08e-25 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 106.23 E-value: 2.08e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 56 WIAMPLTMIVALGI---TYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVATNSNdeIGQLARTFNEMAEELQHADQMRR 132
Cdd:PRK10604 136 LLDIALLALIGLSLafpVFLWMRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSS--LERLGVAFNQMADNINALIASKK 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 133 DVVANVSHELRTPVSALQAMVEnMADGVVEPTPANLEGILGQthrLSDLIAFLLDLSRMEAGAASLNIERFCLHDFLDET 212
Cdd:PRK10604 214 QLIDGIAHELRTPLVRLRYRLE-MSDNLSAAESQALNRDIGQ---LEALIEELLTYARLDRPQNELHLSEPDLPAWLSTH 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 213 IEPLeiaDAGHaHDIMLHVD----SDIWMeGDQDRLRQLFTNIIANALKHSadGTSVLIEARENADTGTIVtnVVNFGSQ 288
Cdd:PRK10604 290 LADI---QAVT-PEKTVRLDtphqGDYGA-LDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLI--VEDDGPG 360
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 542988465 289 IPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLPKYH 352
Cdd:PRK10604 361 IPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESElGGARFSFSWPVWH 425
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
119-357 |
6.18e-25 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 103.77 E-value: 6.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 119 EMAEELQHADQMR--RDVVANVSHELRTPVS----ALQAMVENMADgvvEPTPANLEGILGQTHRLSDLIAFLLDLSRME 192
Cdd:COG3852 121 RLERELRRAEKLAavGELAAGLAHEIRNPLTgirgAAQLLERELPD---DELREYTQLIIEEADRLNNLVDRLLSFSRPR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 193 AgaasLNIERFCLHDFLDETIEPLEiADAGHAHDIMLHVDSDIW-MEGDQDRLRQLFTNIIANALKHSADGTSVLIEAR- 270
Cdd:COG3852 198 P----PEREPVNLHEVLERVLELLR-AEAPKNIRIVRDYDPSLPeVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRv 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 271 -------ENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGpgtesgGTGIGLSIARWAAQLHGGTVRVVDDP-RGA 342
Cdd:COG3852 273 erqvtlgGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK------GTGLGLAIVQKIVEQHGGTIEVESEPgKGT 346
|
250
....*....|....*
gi 542988465 343 DFEIVLPKYHIADDE 357
Cdd:COG3852 347 TFRIYLPLEQAEEEP 361
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
239-350 |
8.49e-25 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 97.33 E-value: 8.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 239 GDQDRLRQLFTNIIANALKHSADGTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRSGPgTESGGTGIG 318
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEIT--VEDNGPGIPPEDLEKIFEPFFRTDKRS-RKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|...
gi 542988465 319 LSIARWAAQLHGGTVRVVDDP-RGADFEIVLPK 350
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPgGGTTFTITLPL 110
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
56-352 |
1.54e-24 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 104.24 E-value: 1.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 56 WIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYsvrvhvATNSNDEIG-----QLARTFNEMAEELQHADQM 130
Cdd:PRK09470 169 LLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNL------RQHPELETGpqefrQAGASFNQMVTALERMMTS 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 131 RRDVVANVSHELRTPVSALQamvenMA---------DGvveptpANLEGILGQTHRLSDLIAFLLDLSRMEAGAAsLNIE 201
Cdd:PRK09470 243 QQRLLSDISHELRTPLTRLQ-----LAtallrrrqgES------KELERIETEAQRLDSMINDLLVLSRNQQKNH-LERE 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 202 RFCLHDFLDETIEPLEIaDAGHAHdIMLHVDSDI--WM-EGDQDRLRQLFTNIIANALKHSADGTSVLIEARENadtgTI 278
Cdd:PRK09470 311 TFKANSLWSEVLEDAKF-EAEQMG-KSLTVSAPPgpWPiNGNPNALASALENIVRNALRYSHTKIEVAFSVDKD----GL 384
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 542988465 279 VTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDPRGA-DFEIVLPKYH 352
Cdd:PRK09470 385 TITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGlRLTIWLPLYK 459
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
61-358 |
1.91e-24 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 105.11 E-value: 1.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 61 LTMIVALGITYFF--SRGLIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLARTFN-------------------- 118
Cdd:PRK15347 303 LLILVLLTSVLFLllRRYLAKPLWRFVDIINKTGPAALEPRLPE--NRLDELGSIAKAYNqlldtlneqydtlenkvaer 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 119 --EMAEELQHADQMRR---DVVANVSHELRTPVSALQAMVEnmadgVVEPTPANLEGI-LGQTHR-----LSDLIAFLLD 187
Cdd:PRK15347 381 tqALAEAKQRAEQANKrksEHLTTISHEIRTPLNGVLGALE-----LLQNTPLTAEQMdLADTARqctlsLLAIINNLLD 455
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 188 LSRMEAGAASLNIERFCLHDFLDETIepLEIADAGHAHDIMLH--VDSDI--WMEGDQDRLRQLFTNIIANALKHSADGT 263
Cdd:PRK15347 456 FSRIESGQMTLSLEETALLPLLDQAM--LTIQGPAQSKSLTLRtfVGAHVplYLHLDSLRLRQILVNLLGNAVKFTETGG 533
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 264 SVLIEARENAdtgTIVTNVVNFGSQIPVEERSDIFRRFVKGrsgpGTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGA 342
Cdd:PRK15347 534 IRLRVKRHEQ---QLCFTVEDTGCGIDIQQQQQIFTPFYQA----DTHSQGTGLGLTIASSLAKMMGGELTLFSTPgVGS 606
|
330
....*....|....*.
gi 542988465 343 DFEIVLPKYHIADDEP 358
Cdd:PRK15347 607 CFSLVLPLNEYAPPEP 622
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
8-368 |
1.46e-23 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 102.55 E-value: 1.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 8 DRKQARLDfDRPIGLFSSLKMELSVLIVIA---TSIAFVLVWFLLKYGWSGWIAMPLTMIVALG-ITY-FFSRGLIAPLR 82
Cdd:TIGR02956 283 LQKQQRLQ-QANLEQFTQLNTTVSQLVNAQnqrTEAAVSDLLMTLSVAQFGLLITGMLGLVILVfIMWrVVYRSVILRLN 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 83 QLRDAAEAMSEGDysVRVHVATNSNDEIGQLART-----------FNEMAEELQHADQMR-------------------- 131
Cdd:TIGR02956 362 QHTQALLRLALGD--LDISLDARGDDELAHMGRAieafrdtaahnLKLQADERQVAQELQehkesleqlvaqrtqelaet 439
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 132 --------------RDV-----------VANVSHELRTPVSALQAMVENMADGVVEPTPAN-LEGILGQTHRLSDLIAFL 185
Cdd:TIGR02956 440 nerlnaevknhakaRAEaeeanraksafLATMSHEIRTPLNGILGTLELLGDTGLTSQQQQyLQVINRSGESLLDILNDI 519
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 186 LDLSRMEAGAASLNIERFCLHDFLDETIEPLEiADAGHAH-DIMLHVDSDI--WMEGDQDRLRQLFTNIIANALKHSADG 262
Cdd:TIGR02956 520 LDYSKIEAGHLSISPRPFDLNALLDDVHHLMV-SRAQLKGiQLRLNIPEQLpnWWQGDGPRIRQVLINLVGNAIKFTDRG 598
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 263 tSVLIEARENADTgTIVTNVVNFGSQIPVEERSDIFRRFVK--GRSgpgtESGGTGIGLSIARWAAQLHGGTVRVVDDP- 339
Cdd:TIGR02956 599 -SVVLRVSLNDDS-SLLFEVEDTGCGIAEEEQATLFDAFTQadGRR----RSGGTGLGLAISQRLVEAMDGELGVESELg 672
|
410 420
....*....|....*....|....*....
gi 542988465 340 RGADFEIVLPkyhIADDEPATDGSARALL 368
Cdd:TIGR02956 673 VGSCFWFTLP---LTRGKPAEDSATLTVI 698
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
64-350 |
1.92e-22 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 96.96 E-value: 1.92e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 64 IVALGITYFFS----RGLIAPLRQLRDAAEAMSEGDYS-VRVHvatNSNDEIGQLARTFNEMAEELQHADQMRRDVVANV 138
Cdd:PRK10755 68 LVMVSLTLLICfqavRWITRPLAELQKELEARTADNLTpIAIH---SSTLEIEAVTSALNQLVSRLTSTLDQERLFTADV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 139 SHELRTPVSALQAMVENMAD-GVVEPTPanlegILGQTHRLSDLIAFLLDLSRMEAGAASLNIERFCLhdfLDETIEPL- 216
Cdd:PRK10755 145 AHELRTPLAGIRLHLELLEKqHHIDVAP-----LIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKL---LEDVILPSq 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 217 ----EIADAGHAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEAREnADTGTIVTnVVNFGSQIP-- 290
Cdd:PRK10755 217 delsEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQ-EDGGAVLA-VEDEGPGIDes 294
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 542988465 291 -VEERSDIFRRFvkgrsgpGTESGGTGIGLSIARWAAQLHGGTVRVVD--DPRGADFEIVLPK 350
Cdd:PRK10755 295 kCGELSKAFVRM-------DSRYGGIGLGLSIVSRITQLHHGQFFLQNrqERSGTRAWVWLPK 350
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
239-349 |
6.54e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 89.35 E-value: 6.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 239 GDQDRLRQLFTNIIANALKHSADGTSVLIEAREnADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRSgpgTESGGTGIG 318
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLT--VEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLG 74
|
90 100 110
....*....|....*....|....*....|..
gi 542988465 319 LSIARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:pfam02518 75 LSIVRKLVELLGGTITVESEPgGGTTVTLTLP 106
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
79-350 |
8.41e-22 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 96.38 E-value: 8.41e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 79 APLRQLRDAAEAMSEGDYSVRVHVATnSNDEIGQLARTFNEMAEELQHADQMRRDVVANVSHELRTPVSAL--------- 149
Cdd:PRK09835 211 APIRSVSRQIQNITSKDLDVRLDPQT-VPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitqteials 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 150 QAMVENMADGVVEptpANLEgilgQTHRLSDLIAFLLDLSrmEAGAASLNIERFCLhDFLDETIEPLEIADA-GHAHDIM 228
Cdd:PRK09835 290 QSRSQKELEDVLY---SNLE----ELTRMAKMVSDMLFLA--QADNNQLIPEKKML-DLADEVGKVFDFFEAwAEERGVE 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 229 LHVDSD-IWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRSG 307
Cdd:PRK09835 360 LRFVGDpCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLV--VENPGTPIAPEHLPRLFDRFYRVDPS 437
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 542988465 308 PGTESGGTGIGLSIARWAAQLHGGTVRVVDDPRGADFEIVLPK 350
Cdd:PRK09835 438 RQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLPR 480
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
119-351 |
9.18e-20 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 90.42 E-value: 9.18e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 119 EMAEELQHADqmRRDVV----ANVSHELRTPVSALQAMVENMADGVVEPTPANLEGILGQTHRLSDLIAFLLDLSRMEAG 194
Cdd:COG5809 256 KLEELLRKSE--KLSVVgelaAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 195 aaslNIERFCLHDFLDETIEPLEiADAGHaHDIMLHVDS-----DIWMEGDQdrLRQLFTNIIANALKHSADGTSVLIEA 269
Cdd:COG5809 334 ----KYEPKDLNTLIEEVIPLLQ-PQALL-KNVQIELELeddipDILGDENQ--LKQVFINLLKNAIEAMPEGGNITIET 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 270 RENADTGTIVTnVVNFGSQIPVEERSDIFRRFVKgrsgpgTESGGTGIGLSIARWAAQLHGGTVRV---VDdpRGADFEI 346
Cdd:COG5809 406 KAEDDDKVVIS-VTDEGCGIPEERLKKLGEPFYT------TKEKGTGLGLMVSYKIIEEHGGKITVeseVG--KGTTFSI 476
|
....*
gi 542988465 347 VLPKY 351
Cdd:COG5809 477 TLPIK 481
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
128-349 |
1.18e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 90.48 E-value: 1.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 128 DQMRRDVVANVSHELRTPVSAL--QA---MVENMADGVVEPTPANleGILGQTHRLSDLIAFLLDLSRMEAGAASLNIER 202
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLfgQAeilTLDLASEGSPHARQAS--EIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEW 738
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 203 FCLHDFLDETIEPLEIADAGH-------AHDIMLHVDSDIwmegdqdrLRQLFTNIIANALKHSADGTSVLIEARENADT 275
Cdd:PRK10490 739 LTLEEVVGSALQMLEPGLSGHpinlslpEPLTLIHVDGPL--------FERVLINLLENAVKYAGAQAEIGIDAHVEGER 810
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 542988465 276 GTIvtNVVNFGSQIPVEERSDIFRRFVKGRSgpgtESG--GTGIGLSIARWAAQLHGGTVRVVDDPR-GADFEIVLP 349
Cdd:PRK10490 811 LQL--DVWDNGPGIPPGQEQLIFDKFARGNK----ESAipGVGLGLAICRAIVEVHGGTIWAENRPEgGACFRVTLP 881
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
108-351 |
7.75e-19 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 86.93 E-value: 7.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 108 DEIGQLARTFNEMAEELQHADQmrrdVVANVSHELRTPVSALQAMVENMA----DGVVEPTPANLEGILGQTHR----LS 179
Cdd:PRK09303 132 DELFVLRQENETLLEQLKFKDR----VLAMLAHDLRTPLTAASLALETLElgqiDEDTELKPALIEQLQDQARRqleeIE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 180 DLIAFLLDLSRMEAGAASLNIERFCLHDFLDETIEPLEiaDAGHAHDIMLHVD--SDI-WMEGDQDRLRQLFTNIIANAL 256
Cdd:PRK09303 208 RLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELE--KRWLAKSLEIQTDipSDLpSVYADQERIRQVLLNLLDNAI 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 257 KHSADGTSVLIEARENADTGTIVTnVVNFGSQIPVEERSDIFR-RFVKGRSGpGTEsgGTGIGLSIARWAAQLHGGTVRV 335
Cdd:PRK09303 286 KYTPEGGTITLSMLHRTTQKVQVS-ICDTGPGIPEEEQERIFEdRVRLPRDE-GTE--GYGIGLSVCRRIVRVHYGQIWV 361
|
250
....*....|....*..
gi 542988465 336 VDDP-RGADFEIVLPKY 351
Cdd:PRK09303 362 DSEPgQGSCFHFTLPVY 378
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
123-367 |
3.83e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.11 E-value: 3.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 123 ELQHADQMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPAN-LEGILGQTHRLSDLIAFLLDLSRMEAGAA--SLN 199
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDdLRAITDSGESLLTILNDILDYSAIEAGGKnvSVS 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 200 IERFCLHDFLDETIEPLEiadaGHAHDIMLHVDSDI------WMEGDQDRLRQLFTNIIANALKHSADGTSVLieaRENA 273
Cdd:PRK11466 516 DEPFEPRPLLESTLQLMS----GRVKGRPIRLATDIaddlptALMGDPRRIRQVITNLLSNALRFTDEGSIVL---RSRT 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 274 DTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSgpgtESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLPKYH 352
Cdd:PRK11466 589 DGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSG----KRGGTGLGLTISSRLAQAMGGELSATSTPeVGSCFCLRLPLRV 664
|
250
....*....|....*
gi 542988465 353 IADDEPATDGSARAL 367
Cdd:PRK11466 665 ATAPVPKTVNQAVRL 679
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
56-341 |
3.97e-18 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 85.35 E-value: 3.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 56 WIAMPLT-----------------MIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYS--VRVHVATnsndEIGQLART 116
Cdd:PRK09467 139 WVRVPLTeihqgdfsplfrytlaiGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPppLREYGAS----EVRSVTRA 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 117 FNEMAEELQHADQMRRDVVANVSHELRTPVS----ALQAMVEN---MADGVVEPTpANLEGILGQthrlsdLIAFLLDLS 189
Cdd:PRK09467 215 FNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTrirlATEMMSEEdgyLAESINKDI-EECNAIIEQ------FIDYLRTGQ 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 190 RMEAGAASLNierfclhDFLDETIEpleiADAGHAHDIMLHV-DSDIWMEGDQDRLRQLFTNIIANALKHSADgtsvLIE 268
Cdd:PRK09467 288 EMPMEMADLN-------ALLGEVIA----AESGYEREIETALqPGPIEVPMNPIAIKRALANLVVNAARYGNG----WIK 352
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 542988465 269 ARENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTEsgGTGIGLSIARWAAQLHGGTVRVVDDPRG 341
Cdd:PRK09467 353 VSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEG 423
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
240-349 |
9.70e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 77.92 E-value: 9.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 240 DQDRLRQLFTNIIANALKHSADGTsvLIEAR-ENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIG 318
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGG--RIRCIlEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 542988465 319 LSIARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:cd16925 79 LSIVKEFVELHGGTVTVSDAPgGGALFQVELP 110
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
78-124 |
1.31e-17 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 75.56 E-value: 1.31e-17
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 542988465 78 IAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLARTFNEMAEEL 124
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPV--RSKDEIGELARAFNQMAERL 45
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
116-356 |
1.98e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 77.70 E-value: 1.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 116 TFNEMAEELQHADQMRR--------DVVANVSHELRTPVSALQAMVENMADGV-VEPTPANLEGILGQTHRLSDLIAFLL 186
Cdd:PRK11360 367 IFSDLTERKRLQRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTsDPPSQEYLSVVLREVDRLNKVIDQLL 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 187 DLSRmeagAASLNIERFCLHDFLDETIEPLEiaDAGHAHDIMLHVDSD-----IWMEGDQdrLRQLFTNIIANALKHSAD 261
Cdd:PRK11360 447 EFSR----PRESQWQPVSLNALVEEVLQLFQ--TAGVQARVDFETELDnelppIWADPEL--LKQVLLNILINAVQAISA 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 262 GTSVLIEARENADTGTIVTnVVNFGSQIPVEERSDIFRRFVKgrsgpgTESGGTGIGLSIARWAAQLHGGTVRVVDDP-R 340
Cdd:PRK11360 519 RGKIRIRTWQYSDGQVAVS-IEDNGCGIDPELLKKIFDPFFT------TKAKGTGLGLALSQRIINAHGGDIEVESEPgV 591
|
250
....*....|....*.
gi 542988465 341 GADFEIVLPKYHIADD 356
Cdd:PRK11360 592 GTTFTLYLPINPQGNQ 607
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
57-348 |
4.30e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 76.23 E-value: 4.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 57 IAMPLTMIValgITYFFSRGLiAPLR----QLR----DAAEAMSEGDY--SVRVHVatnsnDEIGQL-ARTFNEMAEElq 125
Cdd:PRK10337 169 VALPIMLII---LMVLLGREL-APLKklalALRmrdpDSETPLNATGVpsEVRPLV-----EALNQLfARTHAMMVRE-- 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 126 hadqmrRDVVANVSHELRTPVSAL--QAMVENMADGvvepTPANLEGILGQTH----RLSDLIAFLLDLSRMEAGAASLN 199
Cdd:PRK10337 238 ------RRFTSDAAHELRSPLAALkvQTEVAQLSDD----DPQARKKALLQLHagidRATRLVDQLLTLSRLDSLDNLQD 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 200 IERFCLHDFLDETIepLEIADAGHAHDIMLHVD---SDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIeaRENADTG 276
Cdd:PRK10337 308 VAEIPLEDLLQSAV--MDIYHTAQQAGIDVRLTlnaHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDV--TLNARNF 383
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 542988465 277 TIVTNvvnfGSQIPVEERSDIFRRFVKGrsgPGTESGGTGIGLSIARWAAQLHGGTVRVVDDPRGAdFEIVL 348
Cdd:PRK10337 384 TVRDN----GPGVTPEALARIGERFYRP---PGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG-FEAKV 447
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
57-335 |
9.32e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 75.49 E-value: 9.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 57 IAMPLTMIVALGITYFF-SRGLIAPLRQLRDAAEAMSEGDYSVRVhvATNSNDEIGQLART--------------FNEMA 121
Cdd:COG4192 330 AIALLSLLLAVLINYFYvRRRLVKRLNALSDAMAAIAAGDLDVPI--PVDGNDEIGRIARLlrvfrdqaiektqeLETEI 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 122 EELQHADQMRRDV----------------VANVSHELRTPVSALQAMV---------ENMADgvvepTPANLEGILGQTH 176
Cdd:COG4192 408 EERKRIEKNLRQTqdeliqaakmavvgqtMTSLAHELNQPLNAMSMYLfsakkaleqENYAQ-----LPTSLDKIEGLIE 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 177 RLSDLIAFLLDLSRmeAGAASLNIERfcLHDFLDETIEPLEIAdaGHAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANAL 256
Cdd:COG4192 483 RMDKIIKSLRQFSR--KSDTPLQPVD--LRQVIEQAWELVESR--AKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNAL 556
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 542988465 257 KHSADGTSVLIEARENADTGTIVtnVVNFGSQIPVEERsdIFRRFVKgrsgpgTESGGTGIGLSIARWAAQLHGGTVRV 335
Cdd:COG4192 557 DAVATQPQISVDLLSNAENLRVA--ISDNGNGWPLVDK--LFTPFTT------TKEVGLGLGLSICRSIMQQFGGDLYL 625
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-341 |
1.20e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 69.41 E-value: 1.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 240 DQDRLRQLFTNIIANALKHSADGTSVLIEARENADTGTIVTNVVNFGsqIPVEERSDIFRRFVKGRSGPGTESGGTGIGL 319
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPG--VSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100
....*....|....*....|..
gi 542988465 320 SIARWAAQLHGGTVRVVDDPRG 341
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLG 100
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
244-349 |
1.52e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 69.06 E-value: 1.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSADGtSVLIEARENADTGTivTNVVNF-----GSQIPVEERSDIFRRFVKGRSGPGTESGGTGIG 318
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEG-EVTLRVSLEEEEED--GVQLRFsvedtGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLG 77
|
90 100 110
....*....|....*....|....*....|..
gi 542988465 319 LSIARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:cd16922 78 LAISKKLVELMGGDISVESEPgQGSTFTFTLP 109
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
2.04e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 68.57 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSADGTSVLIEARENADTGTIvtNVVNFGSQIPVEERSDIFRRFVKGRSGPGTEsgGTGIGLSIAR 323
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNI--MFKNPSSHPLDFKLEKLFERFYRGDNSRNTE--GAGLGLSIAK 76
|
90 100
....*....|....*....|....*.
gi 542988465 324 WAAQLHGGTVRVVDDPRGADFEIVLP 349
Cdd:cd16923 77 AIIELHGGSASAEYDDNHDLFKVRLP 102
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
234-341 |
4.55e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 67.82 E-value: 4.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 234 DIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIeARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVkgRSgPGTESG 313
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEI-KLSADDGAVIR--VEDNGPGIDEEELEALFERFY--RS-DGQNYG 77
|
90 100
....*....|....*....|....*...
gi 542988465 314 GTGIGLSIARWAAQLHGGTVRVVDDPRG 341
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQGG 105
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
63-182 |
1.13e-13 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 71.98 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 63 MIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLARTFNEMAEELQhadQMRRDvVANVSHEL 142
Cdd:COG0840 192 VALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDV--DSKDEIGQLADAFNRMIENLR---ELVGQ-VRESAEQV 265
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 542988465 143 RTPVSALQAMVENMADGVVEpTPANLEGILGQTHRLSDLI 182
Cdd:COG0840 266 ASASEELAASAEELAAGAEE-QAASLEETAAAMEELSATV 304
|
|
| HAMP |
pfam00672 |
HAMP domain; |
72-126 |
2.87e-13 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 63.80 E-value: 2.87e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 542988465 72 FFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLARTFNEMAEELQH 126
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPV--SGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
75-127 |
4.45e-13 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 63.04 E-value: 4.45e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 542988465 75 RGLIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLARTFNEMAEELQHA 127
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPV--DGRDEIGELARAFNEMADRLEET 51
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
121-349 |
4.47e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 70.35 E-value: 4.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 121 AEELQHADQMRRDVVANVSHELRTPvsalqamvenmadgvveptpanLEGILGQTHRL---------------------- 178
Cdd:PRK11091 273 QDALEKASRDKTTFISTISHELRTP----------------------LNGIVGLSRILldteltaeqrkylktihvsait 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 179 -----SDLIafllDLSRMEAGAASLNIERFCLHDFLD--ETIEPLEIADAGHAHDIMLHVDSDIWMEGDQDRLRQLFTNI 251
Cdd:PRK11091 331 lgnifNDII----DMDKMERRKLQLDNQPIDFTDFLAdlENLSGLQAEQKGLRFDLEPLLPLPHKVITDGTRLRQILWNL 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 252 IANALKHSADGTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRSGPGTESG-GTGIGLSIARWAAQLHG 330
Cdd:PRK11091 407 ISNAVKFTQQGGVTVRVRYEEGDMLTFE--VEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMG 484
|
250 260
....*....|....*....|
gi 542988465 331 GTVRVVDDP-RGADFEIVLP 349
Cdd:PRK11091 485 GDITVTSEEgKGSCFTLTIH 504
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-350 |
4.56e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 64.65 E-value: 4.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSAdgTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIAR 323
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTIT--ITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*...
gi 542988465 324 WAAQLHGGTVRVVD-DPRGADFEIVLPK 350
Cdd:cd16949 77 RAIEQHGGKIKASNrKPGGLRVRIWLPA 104
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
30-350 |
6.99e-13 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 69.11 E-value: 6.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 30 LSVLIVIATSIAFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGL----------IAPLRQLRDAA-EAMSEGDysv 98
Cdd:COG3290 21 LLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLaalllklleeIARLVEEREAVlESIREGV--- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 99 rvhVATNSNDEIgqlaRTFNEMAEELQHADQMRRDVVANVSHELRTPVSAlQAMVENMADGVVEPTPANLEG-------- 170
Cdd:COG3290 98 ---IAVDRDGRI----TLINDAARRLLGLDAIGRPIDEVLAEVLETGERD-EEILLNGRVLVVNRVPIRDDGrvvgavat 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 171 ------ILGQTHRLSDL--------------------IAFLLDLSRME-----AGAASLNIERfcLHDFLDETIEPLEIA 219
Cdd:COG3290 170 frdrteLERLEEELEGVkelaealraqrhdfrnhlhtISGLLQLGEYDealeyIDEISEELQE--LIDSLLSRIGNPVLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 220 -------DAGHAHDIMLHVDSDIWMEGDQDRLRQLFT---NIIANALKHSADGTS----VLIEARENADTGTIVtnVVNF 285
Cdd:COG3290 248 alllgkaARARERGIDLTIDIDSDLPDLPLSDTDLVTilgNLLDNAIEAVEKLPEeerrVELSIRDDGDELVIE--VEDS 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 542988465 286 GSQIPVEERSDIFRRfvkGRSGPgtESGGTGIGLSIARWAAQLHGGTVRV-VDDPRGADFEIVLPK 350
Cdd:COG3290 326 GPGIPEELLEKIFER---GFSTK--LGEGRGLGLALVKQIVEKYGGTIEVeSEEGEGTVFTVRLPK 386
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
1.55e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 63.11 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSADGTSVLIE--ARENADTGTIvtNVVNFGSQIPVEERSDIFRRFvkGRSGPGTESGGTGIGLSI 321
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEvgAEDVGEEWTF--YVRDNGIGIDPEYAEKVFGIF--QRLHSREEYEGTGVGLAI 76
|
90 100
....*....|....*....|....*....
gi 542988465 322 ARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:cd16921 77 VRKIIERHGGRIWLESEPgEGTTFYFTLP 105
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
130-194 |
1.59e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 61.84 E-value: 1.59e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 542988465 130 MRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPAN-LEGILGQTHRLSDLIAFLLDLSRMEAG 194
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREyLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
130-194 |
5.00e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 60.66 E-value: 5.00e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 542988465 130 MRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPAN-LEGILGQTHRLSDLIAFLLDLSRMEAG 194
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREyLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
72-349 |
9.94e-12 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 66.24 E-value: 9.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 72 FFSRGLIAP---LRQLRDAAEAMSegDYSVRVHVatnsNDEIGQLARtfnemaeELQHADQMRR--DVVANVSHELRTPV 146
Cdd:PRK13837 399 RQRYGLRPPageLQLLELALDCLA--HAIERRRL----ETERDALER-------RLEHARRLEAvgTLASGIAHNFNNIL 465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 147 SALQAMVEnMADGVVEPTPA---NLEGILGQTHRLSDLIAFLLDLSRMEAGaaslNIERFCLHDFLDETIEPLEIADAGH 223
Cdd:PRK13837 466 GAILGYAE-MALNKLARHSRaarYIDEIISAGARARLIIDQILAFGRKGER----NTKPFDLSELVTEIAPLLRVSLPPG 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 224 AhDIMLHVDSDIW-MEGDQDRLRQLFTNIIANALKHS------------ADGTSVLIEARENADTGTIVT-NVVNFGSQI 289
Cdd:PRK13837 541 V-ELDFDQDQEPAvVEGNPAELQQVLMNLCSNAAQAMdgagrvdislsrAKLRAPKVLSHGVLPPGRYVLlRVSDTGAGI 619
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 542988465 290 PVEERSDIFRRFVKgrsgpgTESGGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:PRK13837 620 DEAVLPHIFEPFFT------TRAGGTGLGLATVHGIVSAHAGYIDVQSTVgRGTRFDVYLP 674
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
125-321 |
1.25e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 66.03 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 125 QHADQMRRDVVANVSHELRTPvsalqamvenmadgvveptpanLEGILG---QTHR--------------------LSDL 181
Cdd:PRK11107 287 QEAARIKSEFLANMSHELRTP----------------------LNGVIGftrQTLKtpltptqrdylqtiersannLLAI 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 182 IAFLLDLSRMEAGAASL-NIErFCLHDFLDETIEPLeiadAGHAHD----IMLHVDSDI--WMEGDQDRLRQLFTNIIAN 254
Cdd:PRK11107 345 INDILDFSKLEAGKLVLeNIP-FSLRETLDEVVTLL----AHSAHEkgleLTLNIDPDVpdNVIGDPLRLQQIITNLVGN 419
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 542988465 255 ALKHSADGT-SVLIEARENADTG-TIVTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSI 321
Cdd:PRK11107 420 AIKFTESGNiDILVELRALSNTKvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVI 488
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-349 |
6.46e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 58.60 E-value: 6.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 250 NIIANALKHSAdgTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIARWAAQLH 329
Cdd:cd16939 7 NLLRNALRYAH--RTVRIALLVSGGRLTLI--VEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWH 82
|
90 100
....*....|....*....|.
gi 542988465 330 GGTVRVVDDPR-GADFEIVLP 349
Cdd:cd16939 83 GGHVECDDSELgGACFRLTWP 103
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
48-320 |
7.39e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 63.11 E-value: 7.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 48 LLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYsvrVHVATNSNDEIGQLARTFNEMAEELQHA 127
Cdd:COG2972 152 LFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL---VRLEVSGNDEIGILARSFNEMVERIKEL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 128 -DQMRRDVVANVSHELRtpvsALQAMVE-----NMadgvveptpanLEGI-----LGQTHRLSDLIAFLLDLSRM----E 192
Cdd:COG2972 229 iEEVYELELEKKEAELK----ALQAQINphflfNT-----------LNSIrwlaeLEDPEEAEEMLEALSKLLRYslskG 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 193 AGAASLNIERFCLHDFLDetiepLEIADAGHAHDIMLHVDSDIWMEGDqdrLRQLFTNIIANALKH----SADGTSVLIE 268
Cdd:COG2972 294 DELVTLEEELELIKSYLE-----IQKLRFGDRLEVEIEIDEELLDLLI---PKLILQPLVENAIEHgiepKEGGGTIRIS 365
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 542988465 269 ARENADTGTIVtnVVNFGSQIPVEERSDIFRRFvkgrsgpGTESGGTGIGLS 320
Cdd:COG2972 366 IRKEGDRLVIT--VEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLR 408
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
128-190 |
1.25e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 56.45 E-value: 1.25e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 542988465 128 DQMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPA--NLEGILGQTHRLSDLIAFLLDLSR 190
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQreYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-342 |
1.41e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 57.86 E-value: 1.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 240 DQDRLRQLFTNIIANALKHSADGTSVLIEARenADTGTIVTNVVNFGSQIPVEERSDIFRRFVK-GRSGPGTESggTGIG 318
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLE--ADTEGIELLVFDEGSGIPDYALNRVFERFYSlPRPHSGQKS--TGLG 76
|
90 100
....*....|....*....|....
gi 542988465 319 LSIARWAAQLHGGTVRVVDDPRGA 342
Cdd:cd16945 77 LAFVQEVAQLHGGRITLRNRPDGV 100
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
126-349 |
1.70e-10 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 62.83 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 126 HADQMRRDVVANVSHELRTPVSALQAMVEnMADGVVEPTPANLEGI-----LGQThrLSDLIAFLLDLSRMEAGAASLNI 200
Cdd:PRK09959 707 NATVAKSQFLATMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAIslayaTGQS--LLGLIGEILDVDKIESGNYQLQP 783
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 201 ERFCLHDFLDETIEPLEIADAghAHDIMLHVDSDI----WMEGDQDRLRQLFTNIIANALKHSADG----TSVLIEAREN 272
Cdd:PRK09959 784 QWVDIPTLVQNTCHSFGAIAA--SKSIALSCSSTFpdhyLVKIDPQAFKQVLSNLLSNALKFTTEGavkiTTSLGHIDDN 861
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542988465 273 AdtGTIVTNVVNFGSQIPVEERSDIFRRFvkGRSGPGTESGGTGIGLSIARWAAQLHGGTVRVVDDPR-GADFEIVLP 349
Cdd:PRK09959 862 H--AVIKMTIMDSGSGLSQEEQQQLFKRY--SQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGiGTTFTITIP 935
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
110-350 |
1.00e-09 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 59.75 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 110 IGQLARTFNEMA--EELQHADQMrrdvVANVSHELRTPVSALQAMVENMadgvveptPANLEGilgqTHRLSDLIafLLD 187
Cdd:COG5805 268 ITEKKEAEELMArsEKLSIAGQL----AAGIAHEIRNPLTSIKGFLQLL--------QPGIED----KEEYFDIM--LSE 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 188 LSRME---------AGAASLNIERFCLHDFLDETIePLEIADAgHAHDI---MLHVDSDIWMEGDQDRLRQLFTNIIANA 255
Cdd:COG5805 330 LDRIEsiiseflalAKPQAVNKEKENINELIQDVV-TLLETEA-ILHNIqirLELLDEDPFIYCDENQIKQVFINLIKNA 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 256 LKHSADGTSVLIEARENaDTGTIVTnVVNFGSQIPVEERSDIFRRFVKgrsgpgTESGGTGIGLSIARWAAQLHGGTVRV 335
Cdd:COG5805 408 IEAMPNGGTITIHTEEE-DNSVIIR-VIDEGIGIPEERLKKLGEPFFT------TKEKGTGLGLMVSYKIIENHNGTIDI 479
|
250
....*....|....*.
gi 542988465 336 V-DDPRGADFEIVLPK 350
Cdd:COG5805 480 DsKVGKGTTFTITLPL 495
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
33-284 |
1.13e-09 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 59.74 E-value: 1.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 33 LIVIATSIAFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQ 112
Cdd:COG2770 192 LLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPV--SRKDEIGE 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 113 LARTFNEMAEELQHADQMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPANLEGILGQTHRLSDLIAFLLDLSRME 192
Cdd:COG2770 270 LARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAAD 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 193 AGAASLNIERFCLHDFLDETIEPLEIADAGHAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEAREN 272
Cdd:COG2770 350 LLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAA 429
|
250
....*....|..
gi 542988465 273 ADTGTIVTNVVN 284
Cdd:COG2770 430 AAEAAAAALELA 441
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
1.35e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 55.12 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANA-----------LKHSADGTSVLIEARENadtgtivtnvvnfGSQIPVEERSDIFRRFVKGRsgPGTEs 312
Cdd:cd16943 4 LNQVLLNLLVNAaqamegrgritIRTWAHVDQVLIEVEDT-------------GSGIDPEILGRIFDPFFTTK--PVGE- 67
|
90 100 110
....*....|....*....|....*....|....*...
gi 542988465 313 gGTGIGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:cd16943 68 -GTGLGLSLSYRIIQKHGGTIRVASVPgGGTRFTIILP 104
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
20-368 |
1.55e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 59.13 E-value: 1.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 20 IGLFSSLKMELSVLIVIATSIAFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSVR 99
Cdd:COG3850 85 LLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDAR 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 100 VHVatNSNDEIGQLARTFNEMAEELQHA-----DQMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPANLEGILGQ 174
Cdd:COG3850 165 VPV--SGRDELGTLARAFNRMADELQELyaeleEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLL 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 175 THRLSDLIAFLLDLSRMEAGAASLNIERFCLHDFLDETIEPLEIADAGHAHDIMLHVDSDIWMEGDQDRLRQLFTNIIAN 254
Cdd:COG3850 243 LLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQA 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 255 ALKHSADGTSVLIEARENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIARWAAQLHGGTVR 334
Cdd:COG3850 323 IANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAG 402
|
330 340 350
....*....|....*....|....*....|....
gi 542988465 335 VVDDPRGADFEIVLPKYHIADDEPATDGSARALL 368
Cdd:COG3850 403 LVDVEGGVAGEGGLVVLIVSIIAGGEAIARGEAL 436
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
3.96e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 53.73 E-value: 3.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSADGTsVLIEARENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRsgPGTESGGT--GIGLSI 321
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDT-GRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTER--PANEAFGQhsGLGLSI 77
|
90 100 110
....*....|....*....|....*....|...
gi 542988465 322 ARWAAQLHGG--TVRVVDDP---RGADFEIVLP 349
Cdd:cd16953 78 SRQIIEAHGGisVAENHNQPgqvIGARFTVQLP 110
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
3.99e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 53.56 E-value: 3.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSAD-GTSVLIEARenadTGTIVT------------NVVNFGSQIPVEERSDIFRRFVKGRSGpgt 310
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTR----TQRQVTlghprhrlalrvSVIDNGPGIPPDLQDTIFYPMVSGREN--- 73
|
90 100 110
....*....|....*....|....*....|....*....
gi 542988465 311 esgGTGIGLSIARWAAQLHGGTVRVVDDPRGADFEIVLP 349
Cdd:cd16918 74 ---GTGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
53-125 |
4.74e-09 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 57.94 E-value: 4.74e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 542988465 53 WSGWIAMPLTMIVALGITYFFSRGLIAPLRQLRDAAEAMSEGDYSvRVHVATNSNDEIGQLARTFNEMAEELQ 125
Cdd:PRK10935 152 AISLLGLILILTLVFFTVRFTRRQVVAPLNQLVTASQQIEKGQFD-HIPLDTTLPNELGLLAKAFNQMSSELH 223
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
119-352 |
5.16e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 58.06 E-value: 5.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 119 EMAEELQHADQMRRDVVANVSHELRTPvsalqamvenmadgvveptpanLEGILG-----QTHRLSDLIAFLldLSRME- 192
Cdd:PRK10841 435 EMAQAAEQASQSKSMFLATVSHELRTP----------------------LYGIIGnldllQTKELPKGVDRL--VTAMNn 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 193 AGAASLNIerfcLHDFLD----ET----IEPLEIAdaghAHDIMLHV-------------------DSDI--WMEGDQDR 243
Cdd:PRK10841 491 SSSLLLKI----ISDILDfskiESeqlkIEPREFS----PREVINHItanylplvvkkrlglycfiEPDVpvALNGDPMR 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSADGtSVLIEARenADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIAR 323
Cdd:PRK10841 563 LQQVISNLLSNAIKFTDTG-CIVLHVR--VDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICE 639
|
250 260 270
....*....|....*....|....*....|
gi 542988465 324 WAAQLHGGTVRVVDDPR-GADFEIVLPKYH 352
Cdd:PRK10841 640 KLINMMDGDISVDSEPGmGSQFTIRIPLYG 669
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-341 |
5.96e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 52.84 E-value: 5.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSadgtSVLIEARENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTesGGTGIGLSIAR 323
Cdd:cd16950 1 LKRVLSNLVDNALRYG----GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT--SGTGLGLAIVQ 74
|
90
....*....|....*...
gi 542988465 324 WAAQLHGGTVRVVDDPRG 341
Cdd:cd16950 75 RISDAHGGSLTLANRAGG 92
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
122-349 |
9.86e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 56.24 E-value: 9.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 122 EELQHADQMR-RDVVANVSHELRTPVSALQAMVENMADGVvePTPANLEG---ILGQTHRLSDLIAFLLDLSRM-EAGAA 196
Cdd:PRK11073 120 EQLQHAQQVAaRDLVRGLAHEIKNPLGGLRGAAQLLSKAL--PDPALTEYtkvIIEQADRLRNLVDRLLGPQRPgTHVTE 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 197 SLN--IERFClhdfldETIEpLEIADaghahDIMLHVDSD-----IWMEGDQdrLRQLFTNIIANALKHSADGTSVLIEA 269
Cdd:PRK11073 198 SIHkvAERVV------QLVS-LELPD-----NVRLIRDYDpslpeLAHDPDQ--IEQVLLNIVRNALQALGPEGGTITLR 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 270 RENADTGTI---------VTNVVNFGSQIPVEERSDIFRRFVKGRSGpgtesgGTGIGLSIARWAAQLHGGTVRVVDDPR 340
Cdd:PRK11073 264 TRTAFQLTLhgeryrlaaRIDIEDNGPGIPPHLQDTLFYPMVSGREG------GTGLGLSIARNLIDQHSGKIEFTSWPG 337
|
....*....
gi 542988465 341 GADFEIVLP 349
Cdd:PRK11073 338 HTEFSVYLP 346
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
114-349 |
1.84e-08 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 55.95 E-value: 1.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 114 ARTFNEMAEELQhaDQMRR--------DVVANVSHELRTPVSALQAMVENMAdgvvEPTPANLEG------ILGQTHRLS 179
Cdd:PRK10364 214 YRRYLRSRQLLQ--DEMKRkeklvalgHLAAGVAHEIRNPLSSIKGLAKYFA----ERAPAGGEAhqlaqvMAKEADRLN 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 180 DLIAFLLDLSRmeagAASLNIERFCLHDFLDETIEPLEiADAgHAHDIMLHVDSDIWME---GDQDRLRQLFTNIIANAL 256
Cdd:PRK10364 288 RVVSELLELVK----PTHLALQAVDLNDLINHSLQLVS-QDA-NSREIQLRFTANDTLPeiqADPDRLTQVLLNLYLNAI 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 257 KHSADGTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKgrsgpgTESGGTGIGLSIARWAAQLHGGTVRVV 336
Cdd:PRK10364 362 QAIGQHGVISVTASESGAGVKIS--VTDSGKGIAADQLEAIFTPYFT------TKAEGTGLGLAVVHNIVEQHGGTIQVA 433
|
250
....*....|....
gi 542988465 337 DDP-RGADFEIVLP 349
Cdd:PRK10364 434 SQEgKGATFTLWLP 447
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
132-357 |
1.43e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 53.10 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 132 RDVVANVSHELRTPVSALQAMVENMADG----VVEPTPANLEgilgQTHRLSDLIAFLLDLSRMEAGAASLNIERFCLHD 207
Cdd:PRK10815 267 RTTLTDLTHSLKTPLAVLQSTLRSLRSGkqmsVEQAEPIMLE----QISRISQQIGYYLHRASMRSEHNLLSRELHSVAP 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 208 FLDETIEPLEIADAGHAHDIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADgtSVLIEARENADTGTIVtnVVNFGS 287
Cdd:PRK10815 343 LLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIV--VEDDGP 418
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 542988465 288 QIPVEERSDIFRRFVKGrsgpGTESGGTGIGLSIARWAAQLHGGTVRVVDDPR-GADFEIVLPKYHIADDE 357
Cdd:PRK10815 419 GIPESKRELIFDRGQRA----DTLRPGQGLGLSVAREITEQYEGKISAGDSPLgGARMEVIFGRQHSTPKD 485
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
2.01e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 48.93 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSADGTSvliEARE------NADTGTIVTNVVNFGSQIPVEERSDIFRRFVKgrsgpgTESGGTGI 317
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGC---ERREltirtsPADDRAVTISVKDTGPGIAEEVAGQLFDPFYT------TKSEGLGM 71
|
90 100 110
....*....|....*....|....*....|...
gi 542988465 318 GLSIARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:cd16920 72 GLSICRSIIEAHGGRLSVESPAgGGATFQFTLP 104
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-349 |
2.06e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 48.74 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALKHSADGTSVLIeaRENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTESGGTGIGLSIAR 323
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITV--RWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVK 78
|
90 100
....*....|....*....|....*..
gi 542988465 324 WAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:cd16952 79 HVMSRHDARLLIASELgKGSRFTCLFP 105
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-349 |
2.54e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 48.69 E-value: 2.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 240 DQDRLRQLFTNIIANALKHSADGTSVLIEAR---ENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKgrsgpgTESGGTG 316
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRirvEADQDGRIVLIVCDNGKGFPREMRHRATEPYVT------TRPKGTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 542988465 317 IGLSIARWAAQLHGGTVRVVDDP-RGADFEIVLP 349
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREaGGACIRIILP 108
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
232-339 |
5.02e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 48.28 E-value: 5.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 232 DSDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEAREnaDTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGPGTE 311
Cdd:cd16947 9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLRE--DEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSA 86
|
90 100
....*....|....*....|....*...
gi 542988465 312 SGGTGIGLSIARWAAQLHGGTVRVVDDP 339
Cdd:cd16947 87 KQGNGLGLTITKRLAESMGGSIYVNSKP 114
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
226-348 |
1.35e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 47.24 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 226 DIMLHVDSDIWMEGDQDRLRQLFTNIIANALKHSADgtSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGr 305
Cdd:cd16954 20 SISLDISPELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGLHLI--VDDDGPGVPESQRSKIFQRGQRL- 94
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 542988465 306 sgpGTESGGTGIGLSIARWAAQLHGGTVRVVDDPRG-ADFEIVL 348
Cdd:cd16954 95 ---DEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGgARFEVVF 135
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
58-124 |
2.53e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 46.20 E-value: 2.53e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542988465 58 AMPLTMIVALGITYFFSRG-LIAPLRQLRDAAEAMSEGDYSVRVHVatNSNDEIGQLARTFNEMAEEL 124
Cdd:PRK10600 129 VFAVFMALLLVFTIIWLRRrLLQPWRQLLSMANAVSHRDFTQRANI--SGRDEMAMLGTALNNMSAEL 194
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-333 |
7.75e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 41.29 E-value: 7.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 240 DQDRLRQLFTNIIANALKHSADG--TSVLIEARENADTGTIVTNVVNFGSQiPVEERSDIFRRFVKGRsgpgTESGGTGI 317
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGgtVSISIYDEEEYLYFEIWDNGHGFSEQ-DLKKALELFYRDDTSR----RSGGHYGM 75
|
90
....*....|....*.
gi 542988465 318 GLSIARWAAQLHGGTV 333
Cdd:cd16975 76 GLYIAKNLVEKHGGSL 91
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-348 |
1.01e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 40.90 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 244 LRQLFTNIIANALK--HSADGTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRsgpgtESG-GTGIGLS 320
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLV--VRDNGPGIAEEHLSRVFDPFFTTK-----PVGkGTGLGLS 73
|
90 100
....*....|....*....|....*....
gi 542988465 321 IARWAAQLHGGTVRVVDDPR-GADFEIVL 348
Cdd:cd16976 74 ISYGIVEEHGGRLSVANEEGaGARFTFDL 102
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
129-297 |
2.40e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 43.00 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 129 QMRRDVVANVSHELRTPVSALQAMVENMADGVVEPTPAN-LEGILGQTHRLSDLIAFLLDLSRMEAGAASLNIERFCLHD 207
Cdd:PRK10618 448 QARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPeLDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQD 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 208 FLDETIepLEIADAGHAHDIML----HVDSDIWMEGDQDRLRQLFTNIIANALKHSADGTSVLIEARENADTGTIVTNVV 283
Cdd:PRK10618 528 LIDEVL--PEVLPAIKRKGLQLlihnHLKAEQLRIGDRDALRKILLLLLNYAITTTAYGKITLEVDQDESSPDRLTIRIL 605
|
170
....*....|....
gi 542988465 284 NFGSQIPVEERSDI 297
Cdd:PRK10618 606 DTGAGVSIKELDNL 619
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
250-349 |
1.37e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 37.65 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 250 NIIANALKHSAD----GTSVLIEARENADTGTIVtnVVNFGSQIPVEERSDIFRRFVKGRsgpgtESGGTGIGLSIARWA 325
Cdd:cd16915 7 NLIDNALDALAAtgapNKQVEVFLRDEGDDLVIE--VRDTGPGIAPELRDKVFERGVSTK-----GQGERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 542988465 326 AQLHGGTVRVVD-DPRGADFEIVLP 349
Cdd:cd16915 80 VERLGGSITVESePGGGTTFSIRIP 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
240-349 |
1.52e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 37.65 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 240 DQDRLRQLFTNIIANALKHSADGTSVLIEARENADtgTIVTNVVNFGSQIPVEERSDIFRRFVKGRSGpGTESGGTGIGL 319
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQ--GVVLSIKDFGIGIPEEDLPRVFDKGFTGENG-RNFQESTGMGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 542988465 320 SIARWAAQLHGGTVRVVDDPR-GADFEIVLP 349
Cdd:cd16948 79 YLVKKLCDKLGHKIDVESEVGeGTTFTITFP 109
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
240-356 |
2.00e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 40.20 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 240 DQDRLRQLFTNIIANALKHS---ADGTSVlIEARENADTGTIVTNVVNFGSQIPVEERSDIFRRFVKGRSgpgTESGGTG 316
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASlrsDEGNKI-VELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRA---DEPGEHG 504
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 542988465 317 IGLS-IARWAAQLhGGTVRVVD-DPRGADFEIVLPKYHIADD 356
Cdd:PRK15053 505 IGLYlIASYVTRC-GGVITLEDnDPCGTLFSIFIPKVKPNDS 545
|
|
| TM_PBP1_LivH_like |
cd06582 |
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two ... |
41-82 |
3.06e-03 |
|
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.
Pssm-ID: 119324 [Multi-domain] Cd Length: 272 Bit Score: 38.95 E-value: 3.06e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 542988465 41 AFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLR 82
Cdd:cd06582 37 AYVAYTLLVALGLPFWLALLLALLVAALLGVLLERLVLRPLR 78
|
|
| LivH |
COG0559 |
Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport ... |
41-82 |
4.09e-03 |
|
Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport and metabolism];
Pssm-ID: 440325 [Multi-domain] Cd Length: 290 Bit Score: 38.51 E-value: 4.09e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 542988465 41 AFVLVWFLLKYGWSGWIAMPLTMIVALGITYFFSRGLIAPLR 82
Cdd:COG0559 47 AYVAYTLATLLGLPLWLALLLAVLVAALLGVLLERLVIRPLR 88
|
|
| PRK11829 |
PRK11829 |
biofilm formation regulator HmsP; Provisional |
61-149 |
7.98e-03 |
|
biofilm formation regulator HmsP; Provisional
Pssm-ID: 183329 [Multi-domain] Cd Length: 660 Bit Score: 38.38 E-value: 7.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542988465 61 LTMIVALGITYFFSRGLIAPLRQLrdAAEAMSEGDYSVRVH----VATNSNDEIGQLARTFNEMAEELQHAdqmrRDVVA 136
Cdd:PRK11829 156 LALVLSVSIAWCINRLIIHPLRAM--AKELEDIGDHGVLHHqltlPAHHQDDELGVLVRNYNRNQQLLADA----YADMG 229
|
90
....*....|...
gi 542988465 137 NVSHelRTPVSAL 149
Cdd:PRK11829 230 RISH--RFPVTEL 240
|
|
| |
