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Conserved domains on  [gi|542192289|ref|XP_003441890|]
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kelch-like protein 11 [Oreochromis niloticus]

Protein Classification

kelch-like protein( domain architecture ID 13605437)

kelch-like protein may act as a substrate adaptor for Cullin 3 ubiquitin ligases

Gene Ontology:  GO:0005515
PubMed:  17120193|10603472|23676014|15544948

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 73-210 4.02e-68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18241:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 135  Bit Score: 219.73  E-value: 4.02e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  73 FTCSAYCSELSRRQNEQRKAGLFCDVTLIFSSGavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSGT 152
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGA---GGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEP 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 542192289 153 RPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18241   78 GPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 205-292 1.22e-47

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18451:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 88  Bit Score: 162.82  E-value: 1.22e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 542192289 285 EREKHFED 292
Cdd:cd18451   81 ERERYFEE 88
PHA03098 super family cl33709
kelch-like protein; Provisional
 95-546 3.48e-43

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 163.79  E-value: 3.48e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGavpgVQTVSAHRSVLSAASQYFMLLLSGQFSE---SLSGrvelkewssgtrpDPDTVESVVQFMYTGEV 171
Cdd:PHA03098   9 FCDESIIIVNG----GGIIKVHKIILSSSSEYFKKMFKNNFKEneiNLNI-------------DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 172 RVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPF 251
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 252 HLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREKHFEDLFRLLRLAQIAPTYLTR-------------VVRKEPLVA 318
Cdd:PHA03098 152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKlkrwklrikkkkiVFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 319 ------NSAACLELVSSALEVHAVRYESPKKADSDLG-----DSYEATIQPRYGQNM------DVIMVVGGVSEGGDYLS 381
Cdd:PHA03098 232 iyskkyNLNKILPRSSTFGSIIYIHITMSIFTYNYITnysplSEINTIIDIHYVYCFgsvvlnNVIYFIGGMNKNNLSVN 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 382 ECVGYFVAEDRWVSLPHIHNHLDGHAIAVTENHLYVAGSMEPSFA-KTVERYNPNLNCWESVSSLTTRKHSFGLTCVRDT 460
Cdd:PHA03098 312 SVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 461 LYIIGGHGNFSPGFKDVSIYEPEQDMWLNLEPAPKILRDVKTVSvEDRYVYVMARTPVdIDSDDGLSTVtTCYDTESCKW 540
Cdd:PHA03098 392 IYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISY-IDNIKVYNIV-ESYNPVTNKW 468


                 ....*.
gi 542192289 541 QEVDSL 546
Cdd:PHA03098 469 TELSSL 474
Kelch smart00612
Kelch domain;
617-663 2.30e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.16  E-value: 2.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 542192289   617 IFIIGGWKNSNHVekqyrKEAYRYCAKRKRWMLLPPLPQPRCRAAAC 663
Cdd:smart00612   2 IYVVGGFDGGQRL-----KSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
 
Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-210 4.02e-68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 219.73  E-value: 4.02e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  73 FTCSAYCSELSRRQNEQRKAGLFCDVTLIFSSGavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSGT 152
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGA---GGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEP 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 542192289 153 RPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18241   78 GPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 205-292 1.22e-47

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 162.82  E-value: 1.22e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 542192289 285 EREKHFED 292
Cdd:cd18451   81 ERERYFEE 88
PHA03098 PHA03098
kelch-like protein; Provisional
 95-546 3.48e-43

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 163.79  E-value: 3.48e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGavpgVQTVSAHRSVLSAASQYFMLLLSGQFSE---SLSGrvelkewssgtrpDPDTVESVVQFMYTGEV 171
Cdd:PHA03098   9 FCDESIIIVNG----GGIIKVHKIILSSSSEYFKKMFKNNFKEneiNLNI-------------DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 172 RVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPF 251
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 252 HLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREKHFEDLFRLLRLAQIAPTYLTR-------------VVRKEPLVA 318
Cdd:PHA03098 152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKlkrwklrikkkkiVFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 319 ------NSAACLELVSSALEVHAVRYESPKKADSDLG-----DSYEATIQPRYGQNM------DVIMVVGGVSEGGDYLS 381
Cdd:PHA03098 232 iyskkyNLNKILPRSSTFGSIIYIHITMSIFTYNYITnysplSEINTIIDIHYVYCFgsvvlnNVIYFIGGMNKNNLSVN 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 382 ECVGYFVAEDRWVSLPHIHNHLDGHAIAVTENHLYVAGSMEPSFA-KTVERYNPNLNCWESVSSLTTRKHSFGLTCVRDT 460
Cdd:PHA03098 312 SVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 461 LYIIGGHGNFSPGFKDVSIYEPEQDMWLNLEPAPKILRDVKTVSvEDRYVYVMARTPVdIDSDDGLSTVtTCYDTESCKW 540
Cdd:PHA03098 392 IYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISY-IDNIKVYNIV-ESYNPVTNKW 468


                 ....*.
gi 542192289 541 QEVDSL 546
Cdd:PHA03098 469 TELSSL 474
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 210-312 1.02e-30

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 116.11  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  210 CVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREKH 289
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 542192289  290 FEDLFRLLRLAQIAPTYLTRVVR 312
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 210-310 6.04e-27

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 105.12  E-value: 6.04e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289   210 CVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREKH 289
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 542192289   290 FEDLFRLLRLAQIAPTYLTRV 310
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 87-201 1.23e-22

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 93.09  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289   87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFM 166
Cdd:pfam00651   2 NELREQGELCDVTLVV------GDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD------VSPEDFEALLEFM 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 542192289  167 YTGEVrVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:pfam00651  70 YTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFL 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 97-205 1.45e-19

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 83.89  E-value: 1.45e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289    97 DVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVTTA 176
Cdd:smart00225   1 DVTLVV------GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD------VSPEDFRALLNFLYTGKLDLPEE 68

                           90       100
                   ....*....|....*....|....*....
gi 542192289   177 NVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:smart00225  69 NVEELLELADYLQIPGLVELCEEFLLKLL 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
365-663 8.13e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.41  E-value: 8.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 365 DVIMVVGGVSeGGDYLSECVGYFVAEDRWVSLPHIHNHLDGHAIAVT-ENHLYVAG-----SMEPSFAKTVERYNPNLNC 438
Cdd:COG3055   23 GKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGgftgaNPSSTPLNDVYVYDPATNT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 439 WESVSSLTTRKHSFGLTCVRDTLYIIGGHGNfSPGFKDVSIYEPEQDMWLNLEPAPKILRDVKTVSVEDRYVYVMartpv 518
Cdd:COG3055  102 WTKLAPMPTPRGGATALLLDGKIYVVGGWDD-GGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDGKILVI----- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 519 didsdDGLStvttcYDTESCKWQEVDSLPlidtycsfqmavaSSNFYHTASccpknytvtheaaqqkisrnisedildsl 598
Cdd:COG3055  176 -----GGRN-----GSGFSNTWTTLAPLP-------------TARAGHAAA----------------------------- 203

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 542192289 599 psevlslegaaicYLGEDIFIIGGwknsnhvEKQYRKEAYRYCAKRKRWMLLPPLPQPRCRAAAC 663
Cdd:COG3055  204 -------------VLGGKILVFGG-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
Kelch smart00612
Kelch domain;
617-663 2.30e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.16  E-value: 2.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 542192289   617 IFIIGGWKNSNHVekqyrKEAYRYCAKRKRWMLLPPLPQPRCRAAAC 663
Cdd:smart00612   2 IYVVGGFDGGQRL-----KSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 405-446 1.05e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 1.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 542192289  405 GHAIAVTENHLYVA-GSMEPSFAKTVERYNPNLNCWESVSSLT 446
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
414-455 3.71e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.69  E-value: 3.71e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 542192289   414 HLYVAGSMEPS-FAKTVERYNPNLNCWESVSSLTTRKHSFGLT 455
Cdd:smart00612   1 KIYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
 
Name Accession Description Interval E-value
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-210 4.02e-68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 219.73  E-value: 4.02e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  73 FTCSAYCSELSRRQNEQRKAGLFCDVTLIFSSGavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSGT 152
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGA---GGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEP 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 542192289 153 RPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18241   78 GPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 205-292 1.22e-47

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 162.82  E-value: 1.22e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 542192289 285 EREKHFED 292
Cdd:cd18451   81 ERERYFEE 88
PHA03098 PHA03098
kelch-like protein; Provisional
 95-546 3.48e-43

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 163.79  E-value: 3.48e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGavpgVQTVSAHRSVLSAASQYFMLLLSGQFSE---SLSGrvelkewssgtrpDPDTVESVVQFMYTGEV 171
Cdd:PHA03098   9 FCDESIIIVNG----GGIIKVHKIILSSSSEYFKKMFKNNFKEneiNLNI-------------DYDSFNEVIKYIYTGKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 172 RVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPF 251
Cdd:PHA03098  72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 252 HLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREKHFEDLFRLLRLAQIAPTYLTR-------------VVRKEPLVA 318
Cdd:PHA03098 152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKlkrwklrikkkkiVFNKRCIKI 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 319 ------NSAACLELVSSALEVHAVRYESPKKADSDLG-----DSYEATIQPRYGQNM------DVIMVVGGVSEGGDYLS 381
Cdd:PHA03098 232 iyskkyNLNKILPRSSTFGSIIYIHITMSIFTYNYITnysplSEINTIIDIHYVYCFgsvvlnNVIYFIGGMNKNNLSVN 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 382 ECVGYFVAEDRWVSLPHIHNHLDGHAIAVTENHLYVAGSMEPSFA-KTVERYNPNLNCWESVSSLTTRKHSFGLTCVRDT 460
Cdd:PHA03098 312 SVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISlNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 461 LYIIGGHGNFSPGFKDVSIYEPEQDMWLNLEPAPKILRDVKTVSvEDRYVYVMARTPVdIDSDDGLSTVtTCYDTESCKW 540
Cdd:PHA03098 392 IYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIY-HDGKIYVIGGISY-IDNIKVYNIV-ESYNPVTNKW 468


                 ....*.
gi 542192289 541 QEVDSL 546
Cdd:PHA03098 469 TELSSL 474
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 210-312 1.02e-30

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 116.11  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  210 CVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREKH 289
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 542192289  290 FEDLFRLLRLAQIAPTYLTRVVR 312
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 210-310 6.04e-27

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 105.12  E-value: 6.04e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289   210 CVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREKH 289
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 542192289   290 FEDLFRLLRLAQIAPTYLTRV 310
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-211 1.86e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 101.80  E-value: 1.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  80 SELSRRQNEQRKAGLFCDVTLIfssgaVPGVQtVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTV 159
Cdd:cd18237    6 ADFMGVMNNMRKQKTLCDVILI-----VEGRE-IKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD------AEPDII 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 542192289 160 ESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18237   74 ELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 205-334 6.29e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 97.85  E-value: 6.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 542192289 285 EREKHFEDLFRLLRLAQIAPTYLTRVVRKEPLVANSAACLELVSSALEVH 334
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFH 130
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-211 1.36e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 96.32  E-value: 1.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWssgtrpDPDTVESVVQFM 166
Cdd:cd18256   12 NKLRGQHEFCDVQLQV------GMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGV------EPDIFHILLDFI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18256   80 YTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-188 3.36e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 93.77  E-value: 3.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTVESVVQFMYTGEVRVT 174
Cdd:cd18186    1 LCDVTLVV------GGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVS------PEAFEALLDYIYTGELELS 68

                         90
                 ....*....|....
gi 542192289 175 TANVHEVLELADRF 188
Cdd:cd18186   69 EENVEELLAAADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 87-201 1.23e-22

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 93.09  E-value: 1.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289   87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFM 166
Cdd:pfam00651   2 NELREQGELCDVTLVV------GDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD------VSPEDFEALLEFM 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 542192289  167 YTGEVrVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:pfam00651  70 YTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFL 103
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-210 1.12e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 88.27  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPD 157
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFP------AHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLT------AS 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 542192289 158 TVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18242   72 TMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 205-334 3.11e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 87.01  E-value: 3.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 542192289 285 EREKHFEDLFRLLRLAQIAPTYLTRVVRKEPLVANSAACLELVSSALEVH 334
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 208-317 8.97e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 85.36  E-value: 8.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEERE 287
Cdd:cd18445    4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 542192289 288 KHFEDLFRLLRLAQIAPTYLTRVVRKEPLV 317
Cdd:cd18445   84 EHLAELLEHVRLPLLSPEYLVQRVEEEELI 113
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 205-334 1.18e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 85.50  E-value: 1.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 542192289 285 EREKHFEDLFRLLRLAQIAPTYLTRVVRKEPLVANSAACLELVSSALEVH 334
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-212 1.25e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 85.03  E-value: 1.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLifssgaVPGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWssgtrpDPDTVESVVQFM 166
Cdd:cd18238    7 HQFYENGELCDVTL------KVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI------DEEAVELLVDFA 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVA 212
Cdd:cd18238   75 YTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 97-205 1.45e-19

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 83.89  E-value: 1.45e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289    97 DVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVTTA 176
Cdd:smart00225   1 DVTLVV------GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD------VSPEDFRALLNFLYTGKLDLPEE 68

                           90       100
                   ....*....|....*....|....*....
gi 542192289   177 NVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:smart00225  69 NVEELLELADYLQIPGLVELCEEFLLKLL 97
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 205-300 2.18e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 83.51  E-value: 2.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPF-HLVRdWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18448    2 LHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAqHLEK-LISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 542192289 284 EEREKHFEDLFRLLRLA 300
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-204 2.72e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 83.87  E-value: 2.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWssgtrpDPDTVESVVQFM 166
Cdd:cd18247   11 EEIRRQGKLCDVTLKV------GDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGI------EPSALEALINFA 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRK 204
Cdd:cd18247   79 YSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-205 3.27e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 84.02  E-value: 3.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIfssgaVPGVQtVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFM 166
Cdd:cd18235   13 NELRKQNLLCDVILV-----ADGVE-IPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQD------VDGKALLLLIDYV 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:cd18235   81 YTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-210 3.71e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 83.66  E-value: 3.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  82 LSRRQNEQRKAGLFCDVTLifssgaVPGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTVES 161
Cdd:cd18250    8 LLRGLSELRAERKFFDVTL------CAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVS------AEILGL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 542192289 162 VVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18250   76 LLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 209-311 1.34e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 81.58  E-value: 1.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 209 NCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREK 288
Cdd:cd18457    5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREE 84

                         90       100
                 ....*....|....*....|...
gi 542192289 289 HFEDLFRLLRLAQIAPTYLTRVV 311
Cdd:cd18457   85 YLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-213 2.30e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 82.18  E-value: 2.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  67 PEEAEEftcSAYCSELSRRQNEQRKAGLFCDVTL-IFSSGAVPGV-QTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVE 144
Cdd:cd18273    1 PEELED---AAHARALLAQLKSFYDARLLTDVTIeVNGPGSGPGSgRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVT 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 542192289 145 LKEwssgtrPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18273   78 IHD------VDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-213 4.21e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 80.77  E-value: 4.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLifssgaVPGVQTVSAHRSVLSAASQYFMLLLS------GQFSESLSGRvelkewssgtrpDPDTVE 160
Cdd:cd18306   10 NALRKNRQFCDVIL------QVGGHEIPAHRAVLACASPYLFELFSsdsdgeSILTVKLDGL------------DPDAVE 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 542192289 161 SVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18306   72 VLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 208-307 5.41e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 79.68  E-value: 5.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEERE 287
Cdd:cd18444    5 SNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERK 84

                         90       100
                 ....*....|....*....|
gi 542192289 288 KHFEDLFRLLRLAQIAPTYL 307
Cdd:cd18444   85 KHLAKLLALIRLPLLTPQFL 104
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-210 6.71e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 80.06  E-value: 6.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTVESVVQFM 166
Cdd:cd18240    9 NELRLEGKLCDVVIRVNGVEFP------AHRNILCACSPYFRALFTNGWNETEKKVYKIPGVS------PEMMELIIEYA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18240   77 YTRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-211 5.78e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 77.95  E-value: 5.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVT 174
Cdd:cd18259   32 LSDVTLLVGGREFP------CHRSVLALCSHYFNAMFTGDFVESISARVEIKD------VDPAVMESLIDFAYTGKLTIN 99

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 542192289 175 TANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18259  100 QGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 96-211 6.06e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 76.64  E-value: 6.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  96 CDVTLIfssgavPGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVTT 175
Cdd:cd18234    2 CDVILI------AGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKD------VDPDALWTLVQYCYTGRLELKE 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 542192289 176 ANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18234   70 DNVESLLATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-205 1.27e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 76.65  E-value: 1.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  84 RRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVV 163
Cdd:cd18338   10 KVMNELRSQNLLCDVTIVAED------VEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE------VDGWTLKMLI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 542192289 164 QFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:cd18338   78 DYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-201 2.73e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 75.07  E-value: 2.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  82 LSRRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpDPDTVES 161
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIP------VQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGI----SVEVMEE 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 542192289 162 VVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18245   71 ILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-213 2.87e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 75.59  E-value: 2.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  80 SELSRRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKewssGTrpDPDTV 159
Cdd:cd18268    8 SELLRQLNSLRQERILTDVILCTGDKEIP------CHRNVLASSSPYFRAMFCNNFRESSQAKVDLK----GI--DSDVL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 542192289 160 ESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18268   76 DQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 206-301 6.88e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 73.51  E-value: 6.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 206 SMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEE 285
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                         90
                 ....*....|....*.
gi 542192289 286 REKHFEDLFRLLRLAQ 301
Cdd:cd18455   81 RKVHLKDLMSSCWRSG 96
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-205 1.82e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 73.22  E-value: 1.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFM 166
Cdd:cd18339   13 NELRSKQLLCDVTIVAED------VEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD------VDGQTLSKLIDYI 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:cd18339   81 YTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-211 2.19e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 73.32  E-value: 2.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  93 GLFCDVTLIFSSGavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELkewsSGTrpDPDTVESVVQFMYTGEVR 172
Cdd:cd18252   19 GLFTDITLQCASG-----QIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKL----SGI--DHDILEALVNYVYTSQIC 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 173 VTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18252   88 ITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-212 3.87e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 72.50  E-value: 3.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  75 CSAYCSELSRRQ--NEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSGT 152
Cdd:cd18265    1 CSGPCHAERILQvlNAYRRSGTFTDVVLLVDGKDFP------CHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAA 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 153 rpdpdtVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVA 212
Cdd:cd18265   75 ------MEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-199 4.93e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 71.74  E-value: 4.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  81 ELSRRQNeqrkAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRV-ELKEWSSGTrpdpdtV 159
Cdd:cd18293    5 QLHRQQN----SGVFCDVLLQAEGESVP------AHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHT------L 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 542192289 160 ESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGE 199
Cdd:cd18293   69 LKLVDFLYTSELEVSSEEAQDVLAAARRLQISELESLCLE 108
PHA02713 PHA02713
hypothetical protein; Provisional
 94-546 5.16e-15

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 78.51  E-value: 5.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFSSGavpgvQTVSAHRSVLSAASQYF-MLLLSGQFSESLSGRVELKEWssgtrpDPDTVESVVQFMYTGEvr 172
Cdd:PHA02713  24 ILCDVIITIGDG-----EEIKAHKTILAAGSKYFrTLFTTPMIIRDLVTRVNLQMF------DKDAVKNIVQYLYNRH-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 173 VTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV-HSLAHMYTLnQLAQRAAETIRRNFHKVIHNEEFFTLPF 251
Cdd:PHA02713  91 ISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMyHRLYEMSHI-PIVKYIKRMLMSNIPTLITTDAFKKTVF 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 252 HLVRDWLCDAE-ITVESEQELFEAIMKWIHHNPEEREKhfedLFRLLRLAQIaptylTRVVRKEPLVANSAACLELVSSA 330
Cdd:PHA02713 170 EILFDIISTNDnVYLYREGYKVTILLKWLEYNYITEEQ----LLCILSCIDI-----QNLDKKSRLLLYSNKTINMYPSC 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 331 LEVHAVRYESPKKADSDLGDSYEATiqpRYGQNMDVIMVvggvseggdylsecvgYFVAEDRWVSLPHIHNHLDGHAIAV 410
Cdd:PHA02713 241 IQFLLDNKQNRNIIPRQLCLVCHDT---KYNVCNPCILV----------------YNINTMEYSVISTIPNHIINYASAI 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 411 TENHLYVAGSM---EPSFAKTVERYNPNLNCWESVSSLTTRKHsFGLTCVRDTLYIIGGHgNFSPGFKDVSIYEPEQDMW 487
Cdd:PHA02713 302 VDNEIIIAGGYnfnNPSLNKVYKINIENKIHVELPPMIKNRCR-FSLAVIDDTIYAIGGQ-NGTNVERTIECYTMGDDKW 379

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 542192289 488 LNLEPAPKILRDVKtVSVEDRYVYVM-ART------------PVDIDSDDGLSTVTTCYDTESCKWQEVDSL 546
Cdd:PHA02713 380 KMLPDMPIALSSYG-MCVLDQYIYIIgGRTehidytsvhhmnSIDMEEDTHSSNKVIRYDTVNNIWETLPNF 450
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-213 5.46e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 72.05  E-value: 5.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 116 HRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKT 195
Cdd:cd18269   42 HRLVLAACSPYFRAMFLSDLEESKKKEVVLED------VDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFT 115

                         90
                 ....*....|....*...
gi 542192289 196 FCGEFLMRKLSMSNCVAV 213
Cdd:cd18269  116 VCVSYLQKRLSLSNCLAI 133
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 205-304 2.02e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 69.38  E-value: 2.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQeLFEAIMKWIHHNPE 284
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGEEEQ-VFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 542192289 285 EREKHFEDLFRLLRLAQIAP 304
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 205-283 2.40e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 68.69  E-value: 2.40e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 206-282 2.78e-14

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 68.20  E-value: 2.78e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 542192289 206 SMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHN 282
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-217 4.80e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 69.53  E-value: 4.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  80 SELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTV 159
Cdd:cd18266   10 NLVLQGLNEQRQRGLFCDVVLVADE------QRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASY------IGL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 542192289 160 ESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAVHSLA 217
Cdd:cd18266   78 KAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-213 5.01e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 69.48  E-value: 5.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 116 HRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKT 195
Cdd:cd18340   42 HRLVLAACSPYFRAMFLSDLEESKKREIVLED------VDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFT 115

                         90
                 ....*....|....*...
gi 542192289 196 FCGEFLMRKLSMSNCVAV 213
Cdd:cd18340  116 VCVSFLQKRLCLSNCLAI 133
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-201 7.95e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 68.04  E-value: 7.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFSsgavPGVQTVSAHRSVLSAASQYF--MLLLSGQfSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEV 171
Cdd:cd18294   13 EFSDVKFLVG----PERQEIFAHKCILAARCEVFraMFLTGPQ-KESTQSPLVLSD------IEPEVFRAVLEFIYTNCV 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 542192289 172 RVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18294   82 TLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-213 1.16e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 68.33  E-value: 1.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVT 174
Cdd:cd18341   27 FVDCTLKAGDKSLP------CHRLILAACSPYFREYFLSEESEEKKKEVVLDN------VDPNIMDMILKYLYSAEIDLN 94

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 175 TANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18341   95 DGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-210 1.90e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 67.55  E-value: 1.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTVESVVQFM 166
Cdd:cd18253   10 NEFRDSRLFTDVIICVEGREFP------CHRAILSACSSYFRAMFCNDHRESREMLVEINGIL------AEAMDCFLQYV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18253   78 YTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-205 2.69e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 67.02  E-value: 2.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSGAVPgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTVESVVQFM 166
Cdd:cd18248   13 NELRLSQQLCDVTLKVKYQDPK--EEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVH------PCVMSRLIEFA 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:cd18248   85 YTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 115-197 3.90e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 65.83  E-value: 3.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 115 AHRSVLSAASQYFMLLLSGQFSESLSGRVELkewssgTRPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLK 194
Cdd:cd18314   20 AHRIVLCARSPVFRSMLTGSMIESNLKEVTL------EDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLE 93


                 ...
gi 542192289 195 TFC 197
Cdd:cd18314   94 KLC 96
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
365-663 8.13e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.41  E-value: 8.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 365 DVIMVVGGVSeGGDYLSECVGYFVAEDRWVSLPHIHNHLDGHAIAVT-ENHLYVAG-----SMEPSFAKTVERYNPNLNC 438
Cdd:COG3055   23 GKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGgftgaNPSSTPLNDVYVYDPATNT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 439 WESVSSLTTRKHSFGLTCVRDTLYIIGGHGNfSPGFKDVSIYEPEQDMWLNLEPAPKILRDVKTVSVEDRYVYVMartpv 518
Cdd:COG3055  102 WTKLAPMPTPRGGATALLLDGKIYVVGGWDD-GGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDGKILVI----- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 519 didsdDGLStvttcYDTESCKWQEVDSLPlidtycsfqmavaSSNFYHTASccpknytvtheaaqqkisrnisedildsl 598
Cdd:COG3055  176 -----GGRN-----GSGFSNTWTTLAPLP-------------TARAGHAAA----------------------------- 203

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 542192289 599 psevlslegaaicYLGEDIFIIGGwknsnhvEKQYRKEAYRYCAKRKRWMLLPPLPQPRCRAAAC 663
Cdd:COG3055  204 -------------VLGGKILVFGG-------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 209-311 8.43e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 65.18  E-value: 8.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 209 NCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREK 288
Cdd:cd18446    5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLP 84

                         90       100
                 ....*....|....*....|...
gi 542192289 289 HFEDLFRLLRLAQIAPTYLTRVV 311
Cdd:cd18446   85 LLPRVLENVRLPLLDPWYFVETV 107
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 205-293 1.06e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 64.24  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTL-PFHLV----RDwlcdaEITVESEQELFEAIMKWI 279
Cdd:cd18458    2 LDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLsPCQLValisRD-----ELNVRCESEVYNAVIRWV 76

                         90
                 ....*....|....
gi 542192289 280 HHNPEEREKHFEDL 293
Cdd:cd18458   77 KYDEENRRQYLEAL 90
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 205-286 1.69e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 63.50  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                 ..
gi 542192289 285 ER 286
Cdd:cd18480   81 AR 82
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-211 2.02e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 64.78  E-value: 2.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWssgtrpDPDTVESVVQFM 166
Cdd:cd18249   15 NLLRKHRELCDVVLVV------GAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDI------DERAMELLIDFA 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18249   83 YTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 204-299 2.34e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 63.60  E-value: 2.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 204 KLSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*.
gi 542192289 284 EEREKHFEDLFRLLRL 299
Cdd:cd18459   81 QERRPHLPQVLQHVRL 96
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-213 2.54e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 64.30  E-value: 2.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIfssgavPGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKewssGTrpDPDTVESVVQFMYTGEVRVT 174
Cdd:cd18336   19 LCDVLLI------AGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKME----GV--DPDALKALVHYAYTGVLELK 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 175 TANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18336   87 EDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 209-281 2.57e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 62.80  E-value: 2.57e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 542192289 209 NCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHH 281
Cdd:cd18463    6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-213 2.79e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 65.01  E-value: 2.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  73 FTCSAYCSELSRRQNEQRKAGLFCDVTLIfssgavPGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgt 152
Cdd:cd18267   18 FHKSSYADSVLTHLNLLRQQRLFTDVLLH------AGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHD----- 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 542192289 153 RPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18267   87 SIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-211 3.01e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 64.26  E-value: 3.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtRPDPDTVESVVQFM 166
Cdd:cd18254   14 NTLRKQCMFTDVTLWAGNRSFP------CHRAVLAACSRYFEAMFSNGLRESLDSTVNFHD-----SLHPEVLELLLDFA 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18254   83 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-211 3.41e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 63.84  E-value: 3.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  81 ELSRRQNEQRKAGLFCDVTLIfssgaVPGvQTVSAHRSVLSAASQYFMLLLSGQFSESLSG-RVELkewsSGTRPDPDTV 159
Cdd:cd18258    3 EMLKELNQQRRAKEFTDLKII-----VEG-KEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeKLEL----TMSNINADVL 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 542192289 160 ESVVQFMYTGEVRVTTANVHEVLELADRFllgQLKTFCG---EFLMRKLSMSNCV 211
Cdd:cd18258   73 ELLLEFVYTGSLIIDSANAKTLLEAANKF---QFHTFCKvcvSFLEKQLTASNCL 124
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 204-307 3.66e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 63.16  E-value: 3.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 204 KLSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....
gi 542192289 284 EEREKHFEDLFRLLRLAQIAPTYL 307
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 204-307 4.38e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 63.01  E-value: 4.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 204 KLSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....
gi 542192289 284 EEREKHFEDLFRLLRLAQIAPTYL 307
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-205 5.37e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 63.33  E-value: 5.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPD 157
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRV------GDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQC------IDET 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 542192289 158 TVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:cd18257   69 ALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 95-188 6.11e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 61.80  E-value: 6.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGavpgvqTVSAHRSVLSAASQYFMLLlsgqfseslsgrveLKEWSSGTRP-------DPDTVESVVQFMY 167
Cdd:cd18315    1 LVDVTLACEGG------SLKAHKLVLAAASPYFAAL--------------LKETPPDEHPviilpdvPYSELKALLDFIY 60

                         90       100
                 ....*....|....*....|.
gi 542192289 168 TGEVRVTTANVHEVLELADRF 188
Cdd:cd18315   61 TGEVNVSQEQLESLLKLAELL 81
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-213 1.41e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 62.67  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  69 EAEEFTCSAYCSELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEW 148
Cdd:cd18244    4 DVEVYNSSIHDTSVSAGFRALYEEGLLLDVTLVIED------HQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 542192289 149 SsgtrpdPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18244   78 T------ATGFSHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 205-294 1.71e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 61.03  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFtlpfHLVRDWLCDA----EITVESEQELFEAIMKWIH 280
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFL----HLTKDQLISIlnsdDLNVEKEEHVYESIIHWFE 76

                         90
                 ....*....|....
gi 542192289 281 HNPEEREKHFEDLF 294
Cdd:cd18483   77 HEQSKREMHLPEIF 90
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 205-299 1.75e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 60.84  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 542192289 285 EREKHFEDLFRLLRL 299
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 205-299 1.75e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 60.93  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTL-PFHLVRDWLCDAeITVESEQELFEAIMKWIHHNP 283
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLsPDELIAIISSDS-LNVEKEEDVFEAVMKWVGKDQ 79

                         90
                 ....*....|....*.
gi 542192289 284 EEREKHFEDLFRLLRL 299
Cdd:cd18516   80 EERTKALPVLLESIRF 95
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-210 1.79e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 61.64  E-value: 1.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVESVVQFM 166
Cdd:cd18255   10 NALRAKGQLLDVTLIADG------QRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSA------KGLKHILDFA 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18255   78 YTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-206 1.87e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 61.90  E-value: 1.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  76 SAYCSELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESlsgrvelKEWSSGTRPD 155
Cdd:cd18201    2 NSYCYQLLQELNEQRKKGILCDVNIVVSG------KVFRAHKNILVAGSRFFKTLYCFTNKES-------CDQTTVTHLD 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 542192289 156 PDTVES---VVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLS 206
Cdd:cd18201   69 VVAVQGfsvILDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 208-307 1.91e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 60.89  E-value: 1.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEERE 287
Cdd:cd18468    3 SNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRK 82

                         90       100
                 ....*....|....*....|
gi 542192289 288 KHFEDLFRLLRLAQIAPTYL 307
Cdd:cd18468   83 QHIAELLAVVRLPFIHPSYL 102
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-201 2.86e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 61.12  E-value: 2.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  73 FTCSAYCSELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSgrVELKEWSSGT 152
Cdd:cd18278    9 YESTVHCTNILLCLNDQRKQDILCDVTLIVEG------KEFRAHRAVLAACSEYFLQALVGQTENDLV--VSLPEEVTAR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 542192289 153 RPDPdtvesVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18278   81 GFGP-----LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-205 3.01e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 61.58  E-value: 3.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWssgtrpDPDTVESVVQFM 166
Cdd:cd18246   31 NRMRQRGLLCDIVLHVGT------KEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDI------DPQALEQLVQYA 98

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:cd18246   99 YTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 205-298 3.54e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 60.17  E-value: 3.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTL-PFHLVRDWLCDAeITVESEQELFEAIMKWIHHNP 283
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLaPHELIAIISSDS-LNVEKEELVFEAVMKWVRTDK 79

                         90
                 ....*....|....*
gi 542192289 284 EEREKHFEDLFRLLR 298
Cdd:cd18517   80 ENRVKSLGEIFDCIR 94
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 116-202 4.42e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 60.77  E-value: 4.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 116 HRSVLSAASQYFMLLLSGQFSESLSGRVELkewSSGTRPD--PDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQL 193
Cdd:cd18296   32 HKAFFCGRSDYFKALLRDHFAESEENNGSI---PVVTLHDvsPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGL 108


                 ....*....
gi 542192289 194 KTFCGEFLM 202
Cdd:cd18296  109 KRLCGTVLA 117
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-201 5.33e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 60.22  E-value: 5.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  76 SAYCSELSRRQNEQRKAGLFCDVTLIfssgaVPGvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpd 155
Cdd:cd18329    2 SSHQSRLLQQLDEQRKQELFCDCSIL-----VEG-QVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFS----- 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 542192289 156 PDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18329   71 PDTFTIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
393-662 6.54e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 63.64  E-value: 6.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 393 WVSLPHIHNHLDGHAIAVTENHLYVAGSMEPSFA-KTVERYNPNLNCWESVSSL-TTRKHSFGLTCVRDTLYIIGGHGNF 470
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAsNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 471 SPG---FKDVSIYEPEQDMWLNLEPAPKIlRDVKTVSVEDRYVYVMARTpvdidSDDGLSTVTTCYDTESCKWQEVDSLP 547
Cdd:COG3055   83 NPSstpLNDVYVYDPATNTWTKLAPMPTP-RGGATALLLDGKIYVVGGW-----DDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 548 lidtycsfqmavaSSNFYHTASCCPKNytvtheaaqqkisrnisedildslpsevlslegaaicylgeDIFIIGGWKNSN 627
Cdd:COG3055  157 -------------TPRDHLAAAVLPDG-----------------------------------------KILVIGGRNGSG 182

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 542192289 628 HVekqyrkeayrycakrKRWMLLPPLPQPRCRAAA 662
Cdd:COG3055  183 FS---------------NTWTTLAPLPTARAGHAA 202
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 205-282 9.55e-11

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 58.13  E-value: 9.55e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHN 282
Cdd:cd18503    1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 205-283 1.26e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 58.01  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIH-NEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
365-480 1.38e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.87  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 365 DVIMVVGGVSEGGDYlsecvgyfvaeDRWVSLPHIHNHLDGHAIAVTENHLYVAGSmEPSFAKTVERYNPNLNCWESVSS 444
Cdd:COG3055  170 GKILVIGGRNGSGFS-----------NTWTTLAPLPTARAGHAAAVLGGKILVFGG-ESGFSDEVEAYDPATNTWTALGE 237

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 445 LTTRKHSFGLTCVRDTLYIIGGH---GNFSPGFKDVSIY 480
Cdd:COG3055  238 LPTPRHGHAAVLTDGKVYVIGGEtkpGVRTPLVTSAEVY 276
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-201 1.40e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 59.17  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIfssgaVPGVQtVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSGtrpdpdTVESVVQFMYTGEVRVT 174
Cdd:cd18287   22 YSDVTFV-----VEEKR-FPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAE------AFKALLKYIYTGRLTLT 89

                         90       100       110
                 ....*....|....*....|....*....|
gi 542192289 175 T---ANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18287   90 DlkeDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-209 1.51e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 59.59  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLifssgaVPGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVESVVQFM 166
Cdd:cd18261   20 NQQRNDGILCDITL------VAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTS------LGLKQALDFA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18261   88 YTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-200 2.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 58.45  E-value: 2.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  93 GLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYF-MLLLSGQFSESLSGRVELKEwssgtrpDPDTV---ESVVQFMYT 168
Cdd:cd18292   15 EELSDIVLRV------GGKVFHAHRLILAKSSDVFrVMLSNDWWSESKQSEIELVE-------DPECAavfEKFLRYLYT 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 542192289 169 GEVRVTTANVHEVLELADRFLLGQLKTFCGEF 200
Cdd:cd18292   82 GQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-185 2.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 58.35  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSgqfSESLSGRVELKEWSSGTrpdPD 157
Cdd:cd18328    8 HSSEVLCSLNEQRHDGLLCDVVLIVQD------QEYRTHRSVLAACSKYFKKLFT---AGTLADQPYVYEIDFVT---PE 75

                         90       100
                 ....*....|....*....|....*...
gi 542192289 158 TVESVVQFMYTGEVRVTTANVHEVLELA 185
Cdd:cd18328   76 ALSAILEFAYTSTLTITTSNVKHILNAA 103
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-185 3.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 58.32  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  80 SELSRRQNEQRKAGLFCDVTLIfSSGAvpgvqTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVelkewssGTRPD---- 155
Cdd:cd18327   10 SELLSCLNEQRRAGLLCDLTIK-TRGL-----EYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA-------GGGQDvcel 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 542192289 156 ----PDTVESVVQFMYTGEVRVTTANVHEVLELA 185
Cdd:cd18327   77 dfvgPEALGALLEFAYTATLTISSSNMREVLRAA 110
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 205-299 3.37e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 57.26  E-value: 3.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*
gi 542192289 285 EREKHFEDLFRLLRL 299
Cdd:cd18467   81 ERQKYLAQLLHCVRL 95
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-201 3.62e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 58.02  E-value: 3.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVESVVQFM 166
Cdd:cd18326   17 NEQRTQGLLCDVVILVEGREFP------THRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSA------EALTALLDFA 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18326   85 YTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 205-298 3.70e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 57.16  E-value: 3.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTL-PFHLVRDWLCDAeITVESEQELFEAIMKWIHHNP 283
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLsADELIAIISSDG-LNVEKEEAVFEAVMKWVREAK 79

                         90
                 ....*....|....*
gi 542192289 284 EEREKHFEDLFRLLR 298
Cdd:cd18477   80 ENRQKALPTVFESIR 94
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-201 4.05e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 57.77  E-value: 4.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLsgrvelkewsSGTRPDPDTV---ESVV 163
Cdd:cd18277   19 NDQRKKDVLCDVTILVEG------QRFRAHRSVLAACSSYFHSRIVGQADAEL----------NITLPEEVTVkgfEPLI 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 542192289 164 QFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18277   83 QFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-210 4.53e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 57.89  E-value: 4.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  73 FTCSAYCSELSRRQNEQRKAGLFCDVTLifssgaVPG--VQTVSAHRSVLSAASQYFMLLLSGQFSESlsgrvELKEWS- 149
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTL------VPGdgDETFPVHRAMMASASDYFKAMFTGGMKEQ-----ELMCIKl 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 542192289 150 ---SGTrpdpdTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18239   70 hgvSKI-----GLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 208-300 4.80e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 57.12  E-value: 4.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEERE 287
Cdd:cd18464    3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                         90
                 ....*....|...
gi 542192289 288 KHFEDLFRLLRLA 300
Cdd:cd18464   83 EVLPELLRSVRLA 95
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 208-306 4.92e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 57.07  E-value: 4.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEERE 287
Cdd:cd18469    6 TNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQARA 85

                         90
                 ....*....|....*....
gi 542192289 288 KHFEDLFRLLRLAQIAPTY 306
Cdd:cd18469   86 AHLPELLSLVHLSLLTDQY 104
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-213 7.93e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 57.36  E-value: 7.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  84 RRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWssgtrpDPDTVESVV 163
Cdd:cd18335    8 RKMESYLKQQQLCDVILIAGNRKIP------AHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGI------DPNALWDLV 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 542192289 164 QFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18335   76 QFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 208-260 8.90e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 54.59  E-value: 8.90e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCD 260
Cdd:cd14733    3 ENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-209 9.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 56.77  E-value: 9.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELkewssgTRPDPDTVESVVQFMYTGEVRV 173
Cdd:cd18279   17 RFTDCCLCV------GGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEI------NDVDPEVFKEMMRFIYTGKAPN 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 542192289 174 TTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18279   85 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-189 1.01e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 56.73  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  88 EQRKAGLFCDVTLIfssgaVPGVQtVSAHRSVLSAASQYFMLLLS--GQFSES---LSGRVelkewssgtrpdPDTVESV 162
Cdd:cd18212   16 EQRKKDFLCDITLI-----VENVQ-FRAHKALLAASSEYFSMMFAdeGEVGQSiymLEGMV------------AETFGAL 77

                         90       100
                 ....*....|....*....|....*..
gi 542192289 163 VQFMYTGEVRVTTANVHEVLELAdRFL 189
Cdd:cd18212   78 LEFIYTGCLQVGEKSLEQILATA-QFL 103
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 205-299 1.06e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 56.16  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90
                 ....*....|....*
gi 542192289 285 EREKHFEDLFRLLRL 299
Cdd:cd18456   81 GRRQHVPRLMKCVRL 95
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 109-209 1.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 56.17  E-value: 1.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 109 GVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRF 188
Cdd:cd18343   29 GGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND------VDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKY 102

                         90       100
                 ....*....|....*....|.
gi 542192289 189 LLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18343  103 ALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-201 2.07e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 55.51  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIfssgaVPGvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdPD 157
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSII-----VEG-RIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFS-----SD 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 542192289 158 TVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18199   70 AFSIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 217-279 2.16e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 54.12  E-value: 2.16e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 542192289 217 AHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWI 279
Cdd:cd18493   12 AKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-201 2.91e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 55.26  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  80 SELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTV 159
Cdd:cd18198   10 SEILSGLNEQRTQGLLCDVVILVQG------REYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVS------PEAL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 542192289 160 ESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18198   78 TALLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 111-211 3.05e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 55.63  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 111 QTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKewssGTrpDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLL 190
Cdd:cd18236   34 QEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIK----GV--DAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQF 107

                         90       100
                 ....*....|....*....|.
gi 542192289 191 GQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18236  108 LRMVDACASFLTEALHPENCV 128
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-210 3.39e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 55.42  E-value: 3.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIfssgaVPGvQTVSAHRSVLSAASQYFMLLLSGQFSESLsgrvELkewsSGTRPdPDTVESVVQFM 166
Cdd:cd18289   21 NEQRLMGLYCDVSIV-----VKG-QAFKAHRAVLAASSLYFRDLFSGNSKSAF----EL----PATVP-PACFQQILSFC 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 542192289 167 YTGEVRVTTANVHEVLELADrFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18289   86 YTGKLTMAASEQLVVMYTAG-FLQIQHIVERGTDLMFKVSSPHC 128
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 111-213 3.40e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 55.38  E-value: 3.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 111 QTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELkewssgTRPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLL 190
Cdd:cd18274   33 KTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI------VGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQI 106

                         90       100
                 ....*....|....*....|...
gi 542192289 191 GQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18274  107 PSLQDQCAQFMISRLDPQNSIGV 129
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 93-197 3.55e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 54.94  E-value: 3.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  93 GLFCDVTLIFSSGavpgvqTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVESVVQFMYTGEVR 172
Cdd:cd18300    7 GLFSDVTFIVEDG------TIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSK------ETFLALLEYLYTDQAP 74

                         90       100
                 ....*....|....*....|....*.
gi 542192289 173 VTTAN-VHEVLELADRFLLGQLKTFC 197
Cdd:cd18300   75 ILEDGdCVGLIVLANRLCLPRLVALC 100
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-211 3.66e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 55.02  E-value: 3.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLllsgqfsESLSGRVELkEWssgTRPDPDTVESVVQFMYTGEVRV 173
Cdd:cd18303   17 LYSDITIKLAD------KSIPAHKFVLAARSEKWSN-------ENLASTNEL-DL---SDISYEVVLALLRWLYTDELDL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 542192289 174 TTANVH--EVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18303   80 TLDDEFllELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 205-307 4.19e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 54.64  E-value: 4.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|...
gi 542192289 285 EREKHFEDLFRLLRLAQIAPTYL 307
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLL 104
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-173 4.36e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 54.90  E-value: 4.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSgqfSESLSGRVELKEWSSGTRPDPD 157
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFR------AHRSVLAASSPYFRELLS---SPLPLGAAAVAAAPGATQSPER 71

                         90       100
                 ....*....|....*....|....*.
gi 542192289 158 TVE----------SVVQFMYTGEVRV 173
Cdd:cd18195   72 VLElpgvkagvfsDVLNFIYSSRVAL 97
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 205-300 4.82e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 54.08  E-value: 4.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*.
gi 542192289 285 EREKHFEDLFRLLRLA 300
Cdd:cd18514   81 KRKDYLPELLRNVRLA 96
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-211 4.93e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 55.22  E-value: 4.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  90 RKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTVESVVQFMYTG 169
Cdd:cd18271   19 REQNAFFDFNIIVKDETIP------CHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLS------PKAVKAFLDYAYTG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 542192289 170 EVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18271   87 KAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 208-304 5.32e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 53.96  E-value: 5.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEERE 287
Cdd:cd18485    4 SNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRV 83

                         90
                 ....*....|....*..
gi 542192289 288 KHFEDLFRLLRLAQIAP 304
Cdd:cd18485   84 QHLVELLKQVRLELVSP 100
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 97-209 5.41e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 54.59  E-value: 5.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  97 DVTLIfssgaVPGVqTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELkewssgtrPDP--DTVESVVQFMYTGEVRVT 174
Cdd:cd18297   14 DVTFL-----VEGR-PFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEI--------PDIryDIFQLMMQYLYTGGVESL 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 542192289 175 TANVHEVLEL---ADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18297   80 DVAQDDALELlraASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-185 5.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 54.38  E-value: 5.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLifssgaVPGVQTVSAHRSVLSAASQYFmlllSGQFSESLSGRVELKEWSSGTrpdpdtVESVVQFM 166
Cdd:cd18232   10 NKQREEGQYCDATL------DVGGRVFKAHWSVLACCSHFF----QSLYGDGTSGSVVLPESFAEV------FGLLLDFF 73

                         90
                 ....*....|....*....
gi 542192289 167 YTGEVRVTTANVHEVLELA 185
Cdd:cd18232   74 YTGELALTRENRDRVLLAA 92
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-213 5.52e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 55.07  E-value: 5.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVT 174
Cdd:cd18337   23 LCDVVLVAGDRRIP------AHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEG------VEPNALWALVQYAYTGRLELK 90

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 175 TANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18337   91 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 208-300 8.42e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 53.44  E-value: 8.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEERE 287
Cdd:cd18515    3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                         90
                 ....*....|...
gi 542192289 288 KHFEDLFRLLRLA 300
Cdd:cd18515   83 CYLSELLQTVRLA 95
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-200 8.50e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 53.78  E-value: 8.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIfssgaVPGVQtVSAHRSVLSAASQYFMLLLsgqfseslsgrVELKEWSSGTRPDPDTVESVVQFM 166
Cdd:cd18206   14 NQQRQLGLLCDCTFV-----VDGVD-FKAHKAVLAACSEYFRMLF-----------VDQKDVVHLDISNAAGLGQVLEFM 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEF 200
Cdd:cd18206   77 YTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-190 8.79e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 54.27  E-value: 8.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIfssgaVPGvQTVSAHRSVLSAASQYFMLLlsgqFSESLSGRVELKewssgTRPDPDTVESVVQFM 166
Cdd:cd18290   19 NEQRLQGLYCDVSVV-----VKG-HAFKAHRAVLAASSSYFRDL----FNSSRSAVVELP-----AAVQPQSFQQILSFC 83

                         90       100
                 ....*....|....*....|....
gi 542192289 167 YTGEVRvttanvhevLELADRFLL 190
Cdd:cd18290   84 YTGRLS---------MNVGDQFLL 98
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-201 8.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 54.10  E-value: 8.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  80 SELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGR-------VELKEWS-SG 151
Cdd:cd18228    4 QELLGKLNSLRNEGHFCDVTIRVQD------KIFRAHKVVLAACSDFFRSKLVGQASPRLVLVspagkcvLDLHHVTvTG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 542192289 152 TRPdpdtvesVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18228   78 FAP-------LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-201 1.27e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 53.39  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  85 RQNEQRkagLF----CDVTLIFssgaVPGVQTVSAHRSVLSAASQYFMLLLSGqfSESLSgRVELkewsSGTRPDPDTVE 160
Cdd:cd18231    3 RLNEQR---LFqpdlCDVDIVL----VRQRSTFPAHKGVLAAYSQFFHSLFTQ--NKQLQ-RVEL----SLEALTSQGLQ 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 542192289 161 SVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18231   69 QILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELI 109
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-211 1.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 53.85  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRV 173
Cdd:cd18270   25 LLTDIVLIVEGTEFP------CHKMVLATCSSYFRAMFMSGLSESKQTHVHLRN------VDAATLQIIITYAYTGNLAI 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 542192289 174 TTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18270   93 NDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 94-197 1.79e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 52.60  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFssgavPGVQTVSAHRSVLSAASQYFMLLLSGQFSeslsgrVELKEWSSgtrpdPDTVESVVQFMYTGEVRV 173
Cdd:cd18299   11 SCADVVFIL-----QGGVRIFAHRIVLAAASSVFADLFLMMTV------VTLDSDIT-----PEAFRRVLEFLYTGVLDE 74

                         90       100
                 ....*....|....*....|....
gi 542192289 174 TTANVHEVLELADRFLLGQLKTFC 197
Cdd:cd18299   75 NEDDLKELKDAAELLELFDLVMMC 98
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-208 2.18e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 53.14  E-value: 2.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  81 ELSRRQNEQRKAGLFCDVTLIfssgaVPGvQTVSAHRSVLSAASQYFmlllsgqfsESLSGRVE-LKEWSSGTRPDPDTV 159
Cdd:cd18230    7 HLLRELNEQRQHGILCDVCII-----VEG-KIFKAHKNVLLGSSRYF---------KTLYCQVQkTSDQATVTHLDIVTA 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 542192289 160 E---SVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMS 208
Cdd:cd18230   72 QgfkAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-201 2.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 52.62  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIfssgaVPGvQTVSAHRSVLSAASQYFMLLLSGQFSEslSGRVELKEWSSGTrpdPD 157
Cdd:cd18330    1 YYTKLLGELNEQRKRDFFCDCSII-----VEG-RIFKAHRNILFANSGYFRALLIHYIQD--SGRHSTASLDIVT---SE 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 542192289 158 TVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18330   70 AFSIILDFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-209 2.59e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 53.14  E-value: 2.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFSSG----AVPGVQTVSAHRSVLSAASQYFMLLLSGQFSESlSGRVELkewssgtrPD--PDTVESVVQFMY 167
Cdd:cd18346   21 LLSDVRFVVGKGrprgPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIEL--------PDvePAAFLALLRFLY 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 542192289 168 TGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18346   92 SDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 111-209 3.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 52.80  E-value: 3.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 111 QTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLL 190
Cdd:cd18342   32 QEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND------VEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYAL 105

                         90
                 ....*....|....*....
gi 542192289 191 GQLKTFCGEFLMRKLSMSN 209
Cdd:cd18342  106 ERLKVMCEDALCSNLSVEN 124
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 205-303 3.26e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 51.80  E-value: 3.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNpE 284
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                         90
                 ....*....|....*....
gi 542192289 285 EREKHFEDLFRLLRLAQIA 303
Cdd:cd18470   80 KRVKYAADLLSNIRFGTIS 98
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-210 3.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 52.88  E-value: 3.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  75 CSAYCSELSRRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrP 154
Cdd:cd18264    8 SKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFP------AHRSLLACSSDYFRALFKDYTQESKARVIHLPV------V 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 542192289 155 DPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNC 210
Cdd:cd18264   76 SAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-197 3.95e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 52.06  E-value: 3.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLifssgaVPGVQTVSAHRSVLSAASQYFmlllSGQFSESLSGRVELKEwssgTRPDPD 157
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTI------VIGQFQFKAHRNVLAAFSEYF----GAQYKDTEDNIVFLDQ----SQVSAD 66

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 542192289 158 TVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFC 197
Cdd:cd18217   67 GFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-201 4.25e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 52.27  E-value: 4.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  73 FTCSAYCSELSRRQNEQRK-AGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGR-VELKEWSS 150
Cdd:cd18207    4 YQVSQHSADMLHNLNQQRKsGGRFCDVLLRVGEESFP------AHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISS 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 542192289 151 GTRPDpdtvesVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18207   78 KVFGD------ILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVI 122
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 205-307 4.61e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 51.27  E-value: 4.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90       100
                 ....*....|....*....|...
gi 542192289 285 EREKHFEDLFRLLRLaQIAPTYL 307
Cdd:cd18462   81 KRIECAYDLLSSIKL-DLDEIYL 102
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-200 4.62e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 51.34  E-value: 4.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSG---QFSESLSGRVELKEWSsgtrpdPDTVESVVQFMYTGEV 171
Cdd:cd18307    1 FCDVVISVDN------HSFAAHRNVLAAVSPFVKSLISSndmKATDELSITIDCDYLS------PETVEQLLDYFYTGKI 68

                         90       100
                 ....*....|....*....|....*....
gi 542192289 172 RVTTANVHEVLELADRFLLGQLKTFCGEF 200
Cdd:cd18307   69 VISEKNVEDLLKGAKYFNIPRLKDHCVDF 97
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-213 7.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 51.82  E-value: 7.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  93 GLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSGTrpdpdtVESVVQFMYTGEVR 172
Cdd:cd18272   30 GLFADVTISVEG------KEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESV------FQLLVDYIYHGTVK 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 542192289 173 VTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18272   98 LRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-184 8.50e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 51.03  E-value: 8.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSG-RVELKEwssgtrpdPDTVESVVQF 165
Cdd:cd18209   10 NEERLKGQLCDVLLIV------GDQKFRAHKNVLAASSEYFQSLFTEKENESQSVfQLDFCE--------PDAFENVLNY 75

                         90
                 ....*....|....*....
gi 542192289 166 MYTGEVRVTTANVHEVLEL 184
Cdd:cd18209   76 IYSSSLFVEKSSLAAVQEL 94
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 95-209 8.82e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 50.83  E-value: 8.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGAVpgvqtVSAHRSVLSAASQYFMLLLSgqfseslSGRVELKEWSSGTRPDP-DTVESVVQFMYTGEVRV 173
Cdd:cd18302    5 LYDVTIVSEDGKE-----FPCHKCVLVARLEYFHSMLS-------SSWIEASSCSALTMPIPsDILEIILDYLYTDEASA 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 542192289 174 TTAN-----VHEVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18302   73 VKESqnvefLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-209 9.27e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 51.50  E-value: 9.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWssgtrpDPDTVESVVQFMYTGevRV 173
Cdd:cd18344   22 LFTDCCLLVAG------HEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDL------DPQVFKEMMGFIYTG--KA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 542192289 174 TTANVH----EVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18344   88 PHLHSHsmacDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 96-201 9.33e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 50.16  E-value: 9.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  96 CDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESLsgrvelkewsSGTRPDPDTV---ESVVQFMYTGEVR 172
Cdd:cd18955    2 CDVTIVVED------QRFRAHRAVLAACSDYFLSRVVGQTDGDL----------VITLPEEVTVkgfEPLLQFAYTAKLL 65

                         90       100
                 ....*....|....*....|....*....
gi 542192289 173 VTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18955   66 LSKENVLEVCRCAEFLGVHNIEKACFDFL 94
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 205-278 1.17e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 49.31  E-value: 1.17e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKW 278
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 205-299 1.37e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 49.92  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFH-----LVRDWLCDAEItveseqELFEAIMKWI 279
Cdd:cd14822    1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSalkelLSRDSFCAPEV------DIFNAVRRWC 74

                         90       100
                 ....*....|....*....|
gi 542192289 280 HHNPEEREKHfEDLFRLLRL 299
Cdd:cd14822   75 EHNPDSKEDA-KEILEAVRL 93
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 89-209 1.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 50.90  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  89 QRKAGLFC-----DVTLIFSSGAVPgvQTVSAHRSVLSAASQYFMLLLSGQFSESlSGRVELkewssgtrPD--PDTVES 161
Cdd:cd18281   11 ERFAFLFNnetlsDVHFIVGKGDNE--QRIPAHKFVLSIGSAVFDAMFNGGMATT-SAEIEL--------PDvePAAFLA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 542192289 162 VVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18281   80 LLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-201 1.73e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 50.24  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQfseslsGRVELKEWSSGTRPDPDTVESVVQFM 166
Cdd:cd18332   11 NELRKRDILTDVTLLV------GGTPLRAHKAVLIACSGFFYSIFSGR------VGEGVSVLTLPSGLEARGFQLLLDFM 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18332   79 YTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 97-220 2.17e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 49.95  E-value: 2.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  97 DVTLIFSSGavpgvqTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTVESVVQFMYTGEVRV-TT 175
Cdd:cd18286   19 DITIKVDGK------TFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVS------HAAVSFVLLFIYGGVLDLpDD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 542192289 176 ANVHEVLELADRFLLGQLKTfcgeflmrklsmsncVAVHSLAHMY 220
Cdd:cd18286   87 VNLGELLSLADMYGLDGLKD---------------VVAYTLRRDY 116
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 205-283 3.12e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 48.96  E-value: 3.12e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHED 79
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 205-299 3.26e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 49.03  E-value: 3.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*
gi 542192289 285 EREKHFEDLFRLLRL 299
Cdd:cd18460   81 HRQHFWPELLQHVRL 95
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-201 3.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 49.07  E-value: 3.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  80 SELSRRQNEQRKAGLFCDVTlIFSSGavpgvQTVSAHRSVLSAASQYF--MLLLSGQFSESLSGRVelkewssgtrpDPD 157
Cdd:cd18210    6 SSLLESLNQQRMEGKLCDIS-IHVQG-----RVFRAHRAVLAASSPYFhdQVLLKNMSSISLPGVM-----------DPG 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 542192289 158 TVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18210   69 AFESVLASAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-209 4.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 49.08  E-value: 4.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLifssgAVPGvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELkewssgTRPDPDTVESVVQFMYTGEVRVT 174
Cdd:cd18345   18 FSDVTL-----CVGG-REFQAHKAILAARSPVFNAMFEHEMEERKQNRVEI------TDVDHEVMREMLRFIYTGKAPNL 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 542192289 175 TANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18345   86 DKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 82-186 7.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 48.35  E-value: 7.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  82 LSRRQNEQRKaGLFCDVTLIFSSGavpgvQTVSAHRSVLSAASQYFMlllsgqfseSLSGRVELKEwSSGTRP---DPDT 158
Cdd:cd18311    2 LQRLQNLFNK-TEYCDLTLQFRDN-----EQLKVHRLVLSACTDYFN---------VLEQTCEIVD-DTLIMPnelQADA 65

                         90       100
                 ....*....|....*....|....*...
gi 542192289 159 VESVVQFMYTGEVRVTTANVHEVLELAD 186
Cdd:cd18311   66 VVPVINFMYTGQLEFEEKSYGKLLRTAK 93
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-211 8.49e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 48.27  E-value: 8.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSESlsgRVELKEWSsgtrpdPDTVESVVQFM 166
Cdd:cd18260   10 NRMRQERFLCDLTIATKT------KSFDVHKVVMASCSEYFRNILKKDPSLQ---RVELNDIS------PLGLATVITYA 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCV 211
Cdd:cd18260   75 YTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-173 9.99e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 47.86  E-value: 9.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIfssgavpgVQTVS--AHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVESVVQ 164
Cdd:cd18223   10 NEQRIQGILCDVTIV--------VEDTKfkAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKA------EVFAEILN 75


                 ....*....
gi 542192289 165 FMYTGEVRV 173
Cdd:cd18223   76 FIYSSKVVV 84
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-137 1.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 47.52  E-value: 1.26e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLS--GQFSE 137
Cdd:cd18219    4 YSGSLLKSLNEQRGHGLFCDVTVIVED------RKFRAHKNILSASSTYFHQLFSvaGQVVE 59
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 115-209 1.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 47.47  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 115 AHRSVLSAASQYFMLLLSGQFSESLSGRVELK--EWssgtrpdpDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQ 192
Cdd:cd18352   27 AHRIALLASSDAFRAMFDGGYREKEARDIEIPniRW--------EVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEG 98

                         90
                 ....*....|....*..
gi 542192289 193 LKTFCGEFLMRKLSMSN 209
Cdd:cd18352   99 LKRLCEYTIAQDLTLEN 115
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-209 1.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 47.76  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  81 ELSRRQNEQRKAGLF-----CDVTLIFSSGAvpGVQTVSAHRSVLSAASQYFMLLLSGQFSESlSGRVELKEwssgtrPD 155
Cdd:cd18347    3 QATKPTVQERFAFLFnnevlSDVHFLVGKGL--GSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPD------VE 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 542192289 156 PDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18347   74 PAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 91-212 1.55e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 47.50  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  91 KAGLFCDVTLIFSSGavpgvqTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSsgtrpdPDTVESVVQFMYTGE 170
Cdd:cd18263    9 EKGVGCDVQLEADGS------IFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIP------AKDLRLLISFAYSGI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 542192289 171 VRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVA 212
Cdd:cd18263   77 LHLSWENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 209-295 1.84e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 46.42  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 209 NCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAeitVESEQELFEAIMKWIHHNPEEREk 288
Cdd:cd18481    5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDG---VPCSQNPTAAIEAWINHNKEERE- 80


                 ....*..
gi 542192289 289 HFEDLFR 295
Cdd:cd18481   81 GFSETLT 87
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 209-288 1.88e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 47.06  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 209 NCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWiHHNPEEREK 288
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQVEK 83
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 208-307 2.13e-06

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 46.70  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 208 SNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEERE 287
Cdd:cd18466    4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                         90       100
                 ....*....|....*....|
gi 542192289 288 KHFEDLFRLLRLAQIAPTYL 307
Cdd:cd18466   84 KHVVEVLEPVRFPLLPPQRL 103
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-201 3.45e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 46.42  E-value: 3.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  82 LSRRQNEQRKAGLFCDVTLIfssgaVPGVqTVSAHRSVLSAASQYFMLLL---SGQFSESLsgRVELKEWSSgtrpdpdt 158
Cdd:cd18233    5 LLQQLHEQRIQGLLCDCMLV-----VKGV-CFKAHKNVLAAFSQYFRSLFqnsSSQKNDVF--HLDIKNVGG-------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 542192289 159 VESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18233   69 IGQILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 204-299 3.60e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 45.81  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 204 KLSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*.
gi 542192289 284 EEREKHFEDLFRLLRL 299
Cdd:cd18447   81 PNRQPYMVDILAKVRF 96
PHA02790 PHA02790
Kelch-like protein; Provisional
 155-487 4.00e-06

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 50.04  E-value: 4.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 155 DPDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAVHSLAHMYTLNQLAQRAAETIR 234
Cdd:PHA02790  70 DIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIA 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 235 RNF----HKVIHNEEFFTLPFHLVRDwlcdaEITVESEQELFEAIMKWIHhnpeEREKHFEDLFRLLRLAqIAPTYLT-R 309
Cdd:PHA02790 150 KHFleleDDIIDNFDYLSMKLILESD-----ELNVPDEDYVVDFVIKWYM----KRRNRLGNLLLLIKNV-IRSNYLSpR 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 310 VVRKEPLVANSAACLELVSSALEVHAVRY-ESPKKADSDLgDSYEATIQPRYGQnmdVIMVVGGVSEgGDYLSECVGYFV 388
Cdd:PHA02790 220 GINNVKWILDCTKIFHCDKQPRKSYKYPFiEYPMNMDQII-DIFHMCTSTHVGE---VVYLIGGWMN-NEIHNNAIAVNY 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 389 AEDRWVSLPHIHNHLDGHAIAVTENHLYVAGSM-EPSfakTVERYNPNLNCWESVSSLTTRKHSFGLTCVRDTLYIIGGH 467
Cdd:PHA02790 295 ISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLpNPT---SVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGH 371

                        330       340
                 ....*....|....*....|
gi 542192289 468 gnfSPGFKDVSIYEPEQDMW 487
Cdd:PHA02790 372 ---SETDTTTEYLLPNHDQW 388
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 88-186 6.33e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 45.28  E-value: 6.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  88 EQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFM--LLLSGQFSESLSGRVelkewssgtrpDPDTVESVVQF 165
Cdd:cd18262   11 RLREQRLLLDETVSV------GGRSYGVHSVILAAVSSLFRerLLGSNGPLPPLSLEV-----------TPVGWEAVLTF 73

                         90       100
                 ....*....|....*....|.
gi 542192289 166 MYTGEVRVTTANVHEVLELAD 186
Cdd:cd18262   74 AYTGVLGRNPATVGDILVAAE 94
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-199 8.14e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 45.24  E-value: 8.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSGavpgvqTVSAHRSVLSAASQYFMLLLSGQFSEslsgrVELKEWSSgtrpdPDTVESVVQFM 166
Cdd:cd18229   10 NAQRLGGHFCDVTVRIHDA------SLRAHRCVLAAGSPFFHDKLLLGHSE-----IEVPPVVP-----AQTVRQLVEFM 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 542192289 167 YTGEVRVTTANVHEVLELADrflLGQLKTFCGE 199
Cdd:cd18229   74 YSGSLVVAQSEALQILTAAS---ILQIKTVIDE 103
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 95-172 1.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 45.76  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FCDVTLIFSSGAvpgvqTVSAHRSVLSAASQYFMLLLS--GQFSESLSGRVELKEWSSGTRPDPDTVESVVQFMYTGEVR 172
Cdd:cd18310   18 YSDAEIIVEGGR-----PVPVHRCILAARSPFFRDIFAsaKAEGANTKPKLELRELIPGGIVGYDAFMLVLSYLYSGRLR 92
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-205 1.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 44.69  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTliFSSGAVPGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSgRVELkewssgtrPD--PDTVESVVQFMYTGEV 171
Cdd:cd18282    6 LMADVH--FIVGPPGGTQRIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEI--------PDvePAAFLNLLRYLYCDEI 74

                         90       100       110
                 ....*....|....*....|....*....|....
gi 542192289 172 RVTTANVHEVLELADRFLLGQLKTFCGEFLMRKL 205
Cdd:cd18282   75 DLEPDTVLATLYAAKKYLVPHLARACVQFLETSL 108
Kelch smart00612
Kelch domain;
617-663 2.30e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.16  E-value: 2.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 542192289   617 IFIIGGWKNSNHVekqyrKEAYRYCAKRKRWMLLPPLPQPRCRAAAC 663
Cdd:smart00612   2 IYVVGGFDGGQRL-----KSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-201 2.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 44.07  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYF--MLLLSGQFSESLSGRVElkewssgtrpd 155
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQG------RVFRAHKAVLAASSPYFhdKLLLNDTNCLVLPSVIE----------- 63

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 542192289 156 PDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18200   64 AAAFENLLQLIYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 109-188 2.79e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 42.89  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 109 GVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgTRPDPDTVESVVQFMYTGEVRVTTA-NVHEVLELADR 187
Cdd:cd18190    7 GGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEE----NGISIEAMRAVIDFSVTGRLDLFSVeNVHEVLELASK 82


                 .
gi 542192289 188 F 188
Cdd:cd18190   83 F 83
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-197 3.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 43.69  E-value: 3.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFM-LLLSGQFSESLSGRVELKEWSSGtrpdpdTVESVVQF 165
Cdd:cd18202   11 NQQRLNNQFCDVTLLIEG------EEYKAHKSVLAANSEYFReLFIEKGAVSSHEAVVDLSGFCKS------SFLPLLEF 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 542192289 166 MYTGEVRVTTANVHEVLELADRFLLGQLKTFC 197
Cdd:cd18202   79 AYTSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-197 3.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 44.05  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  76 SAYCSELSRRQNEQRKAGLFCDVTLifssgaVPGVQTVSAHRSVLSAASQYFMLLLSGqfSESLSGRVELKEWSSgtrpd 155
Cdd:cd18224    7 SDHPNNLLKELNKCRLSETMCDVTI------VVGNRSFAAHKAVLACAAGYFQKLFLS--TELDVARTYVVDFIT----- 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 542192289 156 PDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFC 197
Cdd:cd18224   74 PANFEKVLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-185 5.11e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 42.94  E-value: 5.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLifssgaVPGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSgRVELKEWssgtrPDPDTVESVVQFM 166
Cdd:cd18215   11 NRLRSRDILTDVVL------VVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVS-VINLDPE-----IEPEGFRILLDFM 78

                         90
                 ....*....|....*....
gi 542192289 167 YTGEVRVTTANVHEVLELA 185
Cdd:cd18215   79 YTSRLNLREGNIMAVMATA 97
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 205-298 6.87e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 42.20  E-value: 6.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVI--HNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHN 282
Cdd:cd18471    1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLksHPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                         90
                 ....*....|....*.
gi 542192289 283 PeeREKHFEDLFRLLR 298
Cdd:cd18471   81 C--RYQYMDELLQYVR 94
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-189 7.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 42.72  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIfssgaVPGVQtVSAHRSVLSAASQYFMLLLSGQFSESlSGRVELKEWSSgtrpdpDTVESVVQFM 166
Cdd:cd18204   10 NEQRLEGEFCDIAIV-----VEDVK-FRAHRCVLAACSTYFKKLFKKLEVDS-SSVIEIDFLRS------DIFEEVLNYM 76

                         90       100
                 ....*....|....*....|....*..
gi 542192289 167 YTGEVRVTTANVHEVLE----LADRFL 189
Cdd:cd18204   77 YTAKISVKKEDVNLMMSsgqiLGIRFL 103
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 244-310 7.37e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 42.31  E-value: 7.37e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542192289 244 EEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPEEREKHFEDLFRLLRLAQI-APTYLTRV 310
Cdd:cd18453   31 EDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIpAPELVERV 98
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-199 7.60e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 42.74  E-value: 7.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSGQFSEslsgrVELKEWSSgtrpdPDTVESVVQFM 166
Cdd:cd18208   17 NEQRNRGHFCDVTVRIHG------SMLRAHRCVLAAGSPFFQDKLLLGYSD-----IEIPSVVS-----VQSVQKLIDFM 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 542192289 167 YTGEVRVTTANVHEVLELADrflLGQLKTFCGE 199
Cdd:cd18208   81 YSGVLRVSQSEALQILTAAS---ILQIKTVIDE 110
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 405-446 1.05e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 1.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 542192289  405 GHAIAVTENHLYVA-GSMEPSFAKTVERYNPNLNCWESVSSLT 446
Cdd:pfam01344   4 GAGVVVVGGKIYVIgGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-185 1.32e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 42.12  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  81 ELSRRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQfseslSGRVELKEWSSGTRPDPdTVE 160
Cdd:cd18194    9 QLLQCLREQRSQGFLCDCTVLVGSAQFP------AHRAVLASCSMYFHLFYRDR-----LDKRDLVRLNSDIVTAP-AFG 76

                         90       100
                 ....*....|....*....|....*
gi 542192289 161 SVVQFMYTGEVRVTTANVHEVLELA 185
Cdd:cd18194   77 LLLDFMYEGRLALRDLPVEDVLAAA 101
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-185 1.79e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 41.94  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESlsgrvELKEWSSGTRPDPdTVESVVQFM 166
Cdd:cd18325   15 SQQRHQGFLCDCTVLV------GEAQFRAHRAVLASCSMYFHLFYRDQLDKR-----DIVHLNSDIVTAP-AFSLLLEFM 82

                         90
                 ....*....|....*....
gi 542192289 167 YTGEVRVTTANVHEVLELA 185
Cdd:cd18325   83 YEGKLEFSSLPVEDVLAAA 101
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-180 1.82e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 41.34  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  76 SAYCSELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYF-MLLLSGQfseSLSGRVELkewsSGTRP 154
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDD------IYFQAHKAVLAACSSYFrMMFINHQ---HTTAQLNL----SNMKI 68

                         90       100
                 ....*....|....*....|....*.
gi 542192289 155 DPDTVESVVQFMYTGEVRVTTANVHE 180
Cdd:cd18192   69 SAECFDLILQFMYLGKIMTAPSDFEQ 94
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 111-188 1.84e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 40.34  E-value: 1.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542192289 111 QTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEwssgtrPDPDTVESVVQFMYTGEVRVTTANVHEVLELADRF 188
Cdd:cd01165    8 EKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRD------ISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-202 2.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 41.73  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  90 RKAGLFCDVTLIfssgaVPGvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVESVVQFMYTG 169
Cdd:cd18251   18 RDSGILFDVVLV-----VEG-KPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSY------NAMCKILDFIYTS 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 542192289 170 EVRVTTANVHEVLELADRFLLGQLKTFCGEFLM 202
Cdd:cd18251   86 ELELSLDNVQETLTAACQLQIPEVIGFCCDFLM 118
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-213 2.38e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 41.33  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  82 LSRRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVES 161
Cdd:cd18276    8 LLDQLNRMKELAELTDVVLVAEGEKFP------CHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITA------ESVSI 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 542192289 162 VVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSNCVAV 213
Cdd:cd18276   76 ILNYMYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-197 2.44e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 41.38  E-value: 2.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  90 RKAGLFCDVTLifsSGAVPGVQT-VSAHRSVLSAASQYFM-LLLSGQFSESLSGRVELKEWSSgtrpdpDTVESVVQFMY 167
Cdd:cd18211   20 RLLGHLCDVTV---QVEHQGSKEeFSAHKAVLAASSKYFKeVFLNEKISDGKNTNVMLNEIYT------ADFASFLEFVY 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 542192289 168 TGEVRVTTANVHEVLELADRFLLGQLKTFC 197
Cdd:cd18211   91 TAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-206 3.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 41.56  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESlsgrvELKEWSSGTRPDPdTVESVVQFM 166
Cdd:cd18324   15 SEQRHQGFLCDCTVLV------GDAQFRAHRAVLASCSMYFHLFYKDQLDKR-----DIVHLNSDIVTAP-AFALLLEFM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 542192289 167 YTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFLMRKLS 206
Cdd:cd18324   83 YEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKAT 122
Kelch smart00612
Kelch domain;
414-455 3.71e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.69  E-value: 3.71e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 542192289   414 HLYVAGSMEPS-FAKTVERYNPNLNCWESVSSLTTRKHSFGLT 455
Cdd:smart00612   1 KIYVVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-189 4.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 40.65  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  82 LSRRQNEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSgrvelkewSSGTRPDPDTVES 161
Cdd:cd18213    8 LLQQLNMQREFGFLCDCTVAI------GDVYFKAHRAVLAAFSNYFKMIFIHQSSECIK--------IQPTDIQPDIFSY 73

                         90       100
                 ....*....|....*....|....*...
gi 542192289 162 VVQFMYTGEVRVTTANvHEVLELADRFL 189
Cdd:cd18213   74 LLHIMYTGKGPKQSVD-HSRLEEGIRFL 100
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 83-193 4.88e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 40.72  E-value: 4.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  83 SRRQNEQRKAGLFCDVTLIFSSGavpgvqTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSGtrpdpdTVESV 162
Cdd:cd18358    8 ANRIKECLSKGTFSDVTFKLDDG------TINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKV------SMQAV 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 542192289 163 VQFMYTGEVRVTTA-NVHEVLELADRFLLGQL 193
Cdd:cd18358   76 LDYLYTKQLSPTADlDPLELIALANRFCLPHL 107
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 94-209 4.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 40.79  E-value: 4.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  94 LFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLSgqfseslSGRVELKEWSSgtrpdpDTVESVVQFMYTGEVRV 173
Cdd:cd18243   31 LFCDVTLTAQG------QQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSS------IGLRLVLEYLYTANVTL 91

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 542192289 174 TTANVHEVLELADRFLLGQLKTFCGEFLMRKLSMSN 209
Cdd:cd18243   92 SLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 205-286 7.28e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 39.51  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHKVIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNPE 284
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80


                 ..
gi 542192289 285 ER 286
Cdd:cd18465   81 RR 82
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 82-171 7.53e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 39.98  E-value: 7.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  82 LSRRQNEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESlsgrVELKEwssgTRPDPDTVES 161
Cdd:cd18193    8 LLQQLNAQREFGFLCDCTVAI------GDVYFKAHKSVLASFSNYFKMLFVHQTSEC----VRLKP----TDIQPDIFSY 73

                         90
                 ....*....|
gi 542192289 162 VVQFMYTGEV 171
Cdd:cd18193   74 LLHLMYTGKM 83
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 78-194 8.48e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 39.54  E-value: 8.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQrkaGLFCDVTLIfssgaVPGVqTVSAHRSVLSAASQYFMLLLSGQFseslSGR--VELKEwssgTRPD 155
Cdd:cd18295    5 YYDEFLRRLLEQ---GSYSDVTFN-----VHGE-SFPAHRCILSARSPYFAEMFETKW----KDKreINLKH----PLVN 67

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 542192289 156 PDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLK 194
Cdd:cd18295   68 PDAFRALLQYLYTGRLEIHVDDVEDCKRLAKQCRLEELI 106
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 97-151 8.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 39.41  E-value: 8.49e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 542192289  97 DVTLIFSSGAvpgvqTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSG 151
Cdd:cd18191    3 DLRFLLDGGT-----QLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSG 52
PLN02193 PLN02193
nitrile-specifier protein
 406-546 8.61e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 42.64  E-value: 8.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 406 HAIAVTENHLYVAGSMEPSFA-KTVERYNPNLNCWESVS----SLTTRKHSfGLTCVRDTLYIIGGHGNFSpgFKDVSIY 480
Cdd:PLN02193 272 HSMAADEENVYVFGGVSATARlKTLDSYNIVDKKWFHCStpgdSFSIRGGA-GLEVVQGKVWVVYGFNGCE--VDDVHYY 348

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 542192289 481 EPEQDMWLNLE-----PAPkilRDVKTVSVEDRYVYV----MARTPVDIDSDDGLSTVTTCYDTESCKWQEVDSL 546
Cdd:PLN02193 349 DPVQDKWTQVEtfgvrPSE---RSVFASAAVGKHIVIfggeIAMDPLAHVGPGQLTDGTFALDTETLQWERLDKF 420
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-201 1.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 39.15  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  69 EAEEFTCSaycseLSRRQNEQRKAGLFCDVTLIfssgaVPGVQtVSAHRSVLSAASQYF--MLLLSGqfseslSGRVELk 146
Cdd:cd18227    4 EFPDFSST-----ILQKLNQQRQQGQLCDISVV-----VQGHL-FRAHKAVLAASSPYFcdQVLLKN------SRRIVL- 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 542192289 147 ewssgtrPD---PDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL 201
Cdd:cd18227   66 -------PDvmnPRVFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 95-188 1.37e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.47  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  95 FC-DVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGqfSESLSGRVELKEWSSGTrpDPDTVESVVQFMYTGEVRV 173
Cdd:cd18283    1 YCtDVDLVFQGTCFP------VHRAILSARCPFFRDLLSS--SPGYGAEIPVDLPTAGI--DVPMFSALLRYLYTGEFGS 70

                         90
                 ....*....|....*...
gi 542192289 174 ---TTANVHEVLELADRF 188
Cdd:cd18283   71 edsRSQNLDVLIQLSEEF 88
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-203 1.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 39.18  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  87 NEQRKAGLFCDVTLIFSSGavpgvqTVSAHRSVLSAASQYFM-LLLSGQFSESLSGRVelkewssgtrpDPDTVESVVQF 165
Cdd:cd18334   13 NQQRAKGFLCDVIIVVENA------LFRAHKNILAASSMYFKsLVLHDNLINLDTDMV-----------NPTVFRQILDF 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 542192289 166 MYTGEVRVTTA----NVHEVLELADRFLLGQLKTFCGEFLMR 203
Cdd:cd18334   76 IYTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALCRKKLKR 117
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 96-197 1.66e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 38.85  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  96 CDVTLifssgAVPGvQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELkewsSGTRpdPDTVESVVQFMYTGEV---- 171
Cdd:cd18280   15 ADVTF-----NVDG-EKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVI----EDVE--PPVFKALLHFIYKDELpddv 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 542192289 172 --------RVTTANVHEVLELADRFLLGQLKTFC 197
Cdd:cd18280   83 epagsdssSLDTTMAQHLLAAADRYALERLRLLC 116
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-186 1.71e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 38.65  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  78 YCSELSRRQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSESLSGRVelkewssgtrPDPD 157
Cdd:cd18225    6 YSRQLLQQLHTLRKEQQFCDCTIFIGTFHFR------AHKLVLAASSLLFKSLLDSTDTISIDASV----------VSPE 69

                         90       100
                 ....*....|....*....|....*....
gi 542192289 158 TVESVVQFMYTGEVRVTTANVHEVLELAD 186
Cdd:cd18225   70 EFALLLEMVYTGKLPPGKHNFTKIISVAD 98
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 84-193 1.83e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 38.83  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  84 RRQNEQRKA---GLFCDVTLIFSSGavpgvqTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVE 160
Cdd:cd18359    6 RRTNRVKEClakGTFSDVTFMLDDG------TISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSR------SSMR 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 542192289 161 SVVQFMYTGEVRVTT-ANVHEVLELADRFLLGQL 193
Cdd:cd18359   74 AVLEYLYTGQFSSSPdLDDMKLIILANRLCLPHL 107
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 115-203 1.89e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 38.39  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 115 AHRSVLSAASQYFMLLLSGQFSESLSGRVELKEWSSgtrpdpDTVESVVQFMYTGEVRVTTANVHEVLELADRFLLGQLK 194
Cdd:cd18298   26 VHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSY------PVYYAFLRYLYTDQVDLPPEDAIGLLDLANSYCEERLK 99


                 ....*....
gi 542192289 195 TFCGEFLMR 203
Cdd:cd18298  100 KLCEDIIKQ 108
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-185 2.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 38.64  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  85 RQNEQRKAGLFCDVTLIFSSGAVPgvqtvsAHRSVLSAASQYFMLLLSGQFSeslSGRvelkewsSGTRPDPDTVES--- 161
Cdd:cd18956   13 RLRQQRELGFLCDCTVLVGDARFP------AHRAVLAACSVYFHLFYRDRPA---GGR-------DTVRLNGDIVTApaf 76

                         90       100
                 ....*....|....*....|....*.
gi 542192289 162 --VVQFMYTGEVRVTTANVHEVLELA 185
Cdd:cd18956   77 grLLDFMYEGRLDLRSLPVEDVLAAA 102
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 81-208 2.27e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 38.88  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  81 ELSRRQNEQRKAGLFCDVTLIFssgavpGVQTVSAHRSVLSAASQYFMLLLSGQFSESLSGRVELkewsSGTRPDPDTVE 160
Cdd:cd18196    7 QIFQQLNYQRLHGQLCDCVIVV------GNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQL----DSEVVTAEAFA 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 542192289 161 SVVQFMYTGEVRVTTANVHEVLELADRFLLGQLKTFCGEFL-MRKLSMS 208
Cdd:cd18196   77 ALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLtTRTLPMS 125
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-127 2.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 38.44  E-value: 2.48e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 542192289  85 RQNEQRKAGLFCDVTLIfssgaVPGVQtVSAHRSVLSAASQYF 127
Cdd:cd18221    8 RLNEQRELDQFTDITLI-----VDGHQ-FKAHKAVLAACSQFF 44
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-203 2.88e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 38.28  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289  76 SAYCSELSRRQNEQRKAGLFCDVTLIFSSgavpgvQTVSAHRSVLSAASQYFMLLLsgqFSESLsgrVELkewssgtrpD 155
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVEN------SLFRAHKNVLAASSGYFKSLV---LHDNL---IHL---------D 59

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 542192289 156 PDTVESVV-----QFMYTGEVRVTT---ANVHEVLELADRFLLGQLKTFCGEFLMR 203
Cdd:cd18216   60 QDMVSPTVfqqilDFIYTGKLLDSLfeePNLSEVLAAANYLQLPDLAALCRSKLKR 115
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 209-293 2.98e-03

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 37.60  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 209 NCVAVHSLA-HMYTLNqLAQRAAETIRRNFHKVIHNEEFFTLPFHLVrdwlcdaEITVESEQE--------LFEAIMKWI 279
Cdd:cd18502    5 NCIGIRSFAgRMNDSE-LLQKVDSYIQENIEEVAESKEFLKLPRLQI-------EVILESNQElesinerkLCQLVLEWV 76

                         90
                 ....*....|....
gi 542192289 280 HHNPEEREKHFEDL 293
Cdd:cd18502   77 QRSIEEGGLDLDDL 90
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 205-298 4.36e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 37.10  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542192289 205 LSMSNCVAVHSLAHMYTLNQLAQRAAETIRRNFHK-VIHNEEFFTLPFHLVRDWLCDAEITVESEQELFEAIMKWIHHNP 283
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*
gi 542192289 284 EEREKHFEDLFRLLR 298
Cdd:cd18482   81 KERAASAAEVLKCVR 95
Kelch_6 pfam13964
Kelch motif;
450-495 6.27e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.39  E-value: 6.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 542192289  450 HSFGLTCVRDTLYIIGGHGNFSPGFKDVSIYEPEQDMWLNLEPAPK 495
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPT 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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