NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|542188290|ref|XP_005470305|]
View 

protein FAM3C isoform X3 [Oreochromis niloticus]

Protein Classification

FAM3C domain-containing protein( domain architecture ID 10195373)

FAM3C (FAM3 Metabolism Regulating Signaling Molecule C) domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 59-229 3.84e-110

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


:

Pssm-ID: 260114  Cd Length: 171  Bit Score: 313.44  E-value: 3.84e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290  59 RSAGVCGTPRECPAHEISFYIHSGAANVVPPAICVQNKLVLGTALNNAGGGINIVILNGKTGEVLKTDHYNMYSGDVKPF 138
Cdd:cd13940    1 KPKYKCGLSKPCPEDHFAFRIISGAANVVGPKICFEGKIIMSSVLNNVGRGLNIALVNGETGEVLKTGFFDMYSGDVKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290 139 IELLKSIERGSIVIMASYDEPSTKLNDELKNLIAELGSSHIHSLGYRDNWVFVGGKGVTGKSTFEKHIKSDSATNKYDGW 218
Cdd:cd13940   81 LEFLKSIKPGSIVLVASFDDPATKLNDEARKLFAELGSSSIKSLGFRDNWVFVGGKGIKTKSPFEKHIKNDKDTNKYEGW 160

                        170
                 ....*....|.
gi 542188290 219 PELIGLEGCVP 229
Cdd:cd13940  161 PEMIEMEGCIP 171
 
Name Accession Description Interval E-value
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 59-229 3.84e-110

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


Pssm-ID: 260114  Cd Length: 171  Bit Score: 313.44  E-value: 3.84e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290  59 RSAGVCGTPRECPAHEISFYIHSGAANVVPPAICVQNKLVLGTALNNAGGGINIVILNGKTGEVLKTDHYNMYSGDVKPF 138
Cdd:cd13940    1 KPKYKCGLSKPCPEDHFAFRIISGAANVVGPKICFEGKIIMSSVLNNVGRGLNIALVNGETGEVLKTGFFDMYSGDVKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290 139 IELLKSIERGSIVIMASYDEPSTKLNDELKNLIAELGSSHIHSLGYRDNWVFVGGKGVTGKSTFEKHIKSDSATNKYDGW 218
Cdd:cd13940   81 LEFLKSIKPGSIVLVASFDDPATKLNDEARKLFAELGSSSIKSLGFRDNWVFVGGKGIKTKSPFEKHIKNDKDTNKYEGW 160

                        170
                 ....*....|.
gi 542188290 219 PELIGLEGCVP 229
Cdd:cd13940  161 PEMIEMEGCIP 171
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 109-195 3.08e-37

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 125.45  E-value: 3.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290  109 GINIVILNGKTGEVLKTDHYNMYS-GDVKPFIELLKSIERGSIVIMASYDEPSTKLNDELKNLIAELGSSHIHSLGYRDN 187
Cdd:pfam15711   2 GINVVVVDACTGKVLDSKSFDTYSySDSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALESLGSSKIDNLGFRDS 81


                  ....*...
gi 542188290  188 WVFVGGKG 195
Cdd:pfam15711  82 WAFIGFKG 89
 
Name Accession Description Interval E-value
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 59-229 3.84e-110

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


Pssm-ID: 260114  Cd Length: 171  Bit Score: 313.44  E-value: 3.84e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290  59 RSAGVCGTPRECPAHEISFYIHSGAANVVPPAICVQNKLVLGTALNNAGGGINIVILNGKTGEVLKTDHYNMYSGDVKPF 138
Cdd:cd13940    1 KPKYKCGLSKPCPEDHFAFRIISGAANVVGPKICFEGKIIMSSVLNNVGRGLNIALVNGETGEVLKTGFFDMYSGDVKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290 139 IELLKSIERGSIVIMASYDEPSTKLNDELKNLIAELGSSHIHSLGYRDNWVFVGGKGVTGKSTFEKHIKSDSATNKYDGW 218
Cdd:cd13940   81 LEFLKSIKPGSIVLVASFDDPATKLNDEARKLFAELGSSSIKSLGFRDNWVFVGGKGIKTKSPFEKHIKNDKDTNKYEGW 160

                        170
                 ....*....|.
gi 542188290 219 PELIGLEGCVP 229
Cdd:cd13940  161 PEMIEMEGCIP 171
PANDER_FAM3B cd13939
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ...
 70-230 1.26e-44

Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver.


Pssm-ID: 260113  Cd Length: 175  Bit Score: 147.37  E-value: 1.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290  70 CPAHEISFYIHSGAANVVPPAICVQNKLVLGTALNNAGGGINIVILNGKTGEVLKTDHYNMYSGDV-KPFIELLKSIERG 148
Cdd:cd13939   11 CAPNQYAYRIRSGGGKDIMPEICFEDNMLITGKEGNSNRGINIAVVSYETGKVVATKYFDMYEGDFsGPMIEFINKIPKK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290 149 SIVIMASYDEPSTKLNDELKNLIAELGSSHIHSLGYRDNWVFVGGKGVTGKSTFEKH--IKSDSATNKYDGWPELIGLEG 226
Cdd:cd13939   91 SLVFVVTHDDGSTKLKDPAKKAIEDLGSKEIRNLKFRSAWVFIAAKGFQLPDNIEKEkiNHSDGSKNRYSGWPAEIQIEG 170


                 ....
gi 542188290 227 CVPK 230
Cdd:cd13939  171 CIPK 174
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 109-195 3.08e-37

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 125.45  E-value: 3.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290  109 GINIVILNGKTGEVLKTDHYNMYS-GDVKPFIELLKSIERGSIVIMASYDEPSTKLNDELKNLIAELGSSHIHSLGYRDN 187
Cdd:pfam15711   2 GINVVVVDACTGKVLDSKSFDTYSySDSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALESLGSSKIDNLGFRDS 81


                  ....*...
gi 542188290  188 WVFVGGKG 195
Cdd:pfam15711  82 WAFIGFKG 89
PANDER_like cd13936
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 104-228 7.37e-34

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


Pssm-ID: 260110  Cd Length: 149  Bit Score: 118.98  E-value: 7.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290 104 NNAGGGINIVILNGKTGEVLKTDHYNMYS-GDVKPFIELLKSIERGSIVIMASYDEPSTKLNDELKNLIAELGSSHIHSL 182
Cdd:cd13936   27 DKSGRGINVVVINGDTGKVIATKTFDTYGaGASNDMIDFLNSVPPGSIVLIATKDDASKSLKDEARRALESLGSSLIQNL 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 542188290 183 GYRDNWVFVGGKGVTGKSTfEKHIKSDSatNKYDGWPELIGLEGCV 228
Cdd:cd13936  107 GFRDSWAFVGQKGIKRPST-EQHEISPK--NSSWGGPALIQTCFPL 149
PANDER_GnT-1_2_like cd13937
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ...
 91-229 7.98e-25

PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined.


Pssm-ID: 260111  Cd Length: 148  Bit Score: 95.44  E-value: 7.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290  91 ICVQNKLVLGTALNNAGGGINIVILNGKTGEVLKTDHYNMYS-GDVKPFIELLKSIERGSIVIMASYDEPSTKLNDELKN 169
Cdd:cd13937   14 VSVDGTTVLEDEEAEAGRGIHVVVLNQATGSVMAQRVFDTYSpGEDEAMILFLNMVSDGRILIFTIKDEGSFHLKDEARS 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290 170 LIAELGSSHIHSLGYRDNWVFVGGKGvtGKSTFEKHIKSDSatnkYDGWPELIGLEGCVP 229
Cdd:cd13937   94 LLKKLGSQKVSKLGWRDMWAMVTRKG--GPVYGEKHSKSPD----LSSWGEPVLLKAEVP 147
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 109-206 4.80e-20

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


Pssm-ID: 260112  Cd Length: 168  Bit Score: 83.53  E-value: 4.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542188290 109 GINIVILNGKTGEVLKTDHYNMYSG--DVKPFIELLKSIERGSIVIMASYDEPSTKLNDELKNLIAELGSSHIHSLGYRD 186
Cdd:cd13938   49 GINVRVIDEDTGEVLESDRFDTYESedESKRLAEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRELGSKEIDHLGYRQ 128

                         90       100
                 ....*....|....*....|
gi 542188290 187 NWVFVGGKGvTGKSTFEKHI 206
Cdd:cd13938  129 PWAFVGVKG-GPSSAVEDRR 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH