geranylgeranyl transferase type-2 subunit alpha [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
RabGGT_insert | pfam07711 | Rab geranylgeranyl transferase alpha-subunit, insert domain; Rab geranylgeranyl transferase ... |
244-346 | 7.88e-54 | |||||
Rab geranylgeranyl transferase alpha-subunit, insert domain; Rab geranylgeranyl transferase (RabGGT) catalyzes the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. This domain is inserted between pfam01239 repeats. This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP. : Pssm-ID: 462239 Cd Length: 101 Bit Score: 177.62 E-value: 7.88e-54
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BET4 super family | cl44255 | Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ... |
1-237 | 4.89e-48 | |||||
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]; The actual alignment was detected with superfamily member COG5536: Pssm-ID: 227823 [Multi-domain] Cd Length: 328 Bit Score: 170.05 E-value: 4.89e-48
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PPP1R42 super family | cl42388 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
444-547 | 8.64e-14 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. The actual alignment was detected with superfamily member cd21340: Pssm-ID: 455733 [Multi-domain] Cd Length: 220 Bit Score: 70.59 E-value: 8.64e-14
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Name | Accession | Description | Interval | E-value | |||||
RabGGT_insert | pfam07711 | Rab geranylgeranyl transferase alpha-subunit, insert domain; Rab geranylgeranyl transferase ... |
244-346 | 7.88e-54 | |||||
Rab geranylgeranyl transferase alpha-subunit, insert domain; Rab geranylgeranyl transferase (RabGGT) catalyzes the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. This domain is inserted between pfam01239 repeats. This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP. Pssm-ID: 462239 Cd Length: 101 Bit Score: 177.62 E-value: 7.88e-54
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BET4 | COG5536 | Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ... |
1-237 | 4.89e-48 | |||||
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 227823 [Multi-domain] Cd Length: 328 Bit Score: 170.05 E-value: 4.89e-48
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PLN02789 | PLN02789 | farnesyltranstransferase |
40-250 | 1.17e-22 | |||||
farnesyltranstransferase Pssm-ID: 215423 [Multi-domain] Cd Length: 320 Bit Score: 99.05 E-value: 1.17e-22
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
444-547 | 8.64e-14 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 70.59 E-value: 8.64e-14
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
444-545 | 3.86e-12 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.42 E-value: 3.86e-12
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
351-558 | 2.81e-11 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 65.73 E-value: 2.81e-11
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LRR_9 | pfam14580 | Leucine-rich repeat; |
468-545 | 1.03e-05 | |||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 46.30 E-value: 1.03e-05
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PPTA | pfam01239 | Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ... |
162-191 | 4.11e-05 | |||||
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family. Pssm-ID: 460128 [Multi-domain] Cd Length: 32 Bit Score: 40.70 E-value: 4.11e-05
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Name | Accession | Description | Interval | E-value | |||||
RabGGT_insert | pfam07711 | Rab geranylgeranyl transferase alpha-subunit, insert domain; Rab geranylgeranyl transferase ... |
244-346 | 7.88e-54 | |||||
Rab geranylgeranyl transferase alpha-subunit, insert domain; Rab geranylgeranyl transferase (RabGGT) catalyzes the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. This domain is inserted between pfam01239 repeats. This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP. Pssm-ID: 462239 Cd Length: 101 Bit Score: 177.62 E-value: 7.88e-54
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BET4 | COG5536 | Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, ... |
1-237 | 4.89e-48 | |||||
Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 227823 [Multi-domain] Cd Length: 328 Bit Score: 170.05 E-value: 4.89e-48
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PLN02789 | PLN02789 | farnesyltranstransferase |
40-250 | 1.17e-22 | |||||
farnesyltranstransferase Pssm-ID: 215423 [Multi-domain] Cd Length: 320 Bit Score: 99.05 E-value: 1.17e-22
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
444-547 | 8.64e-14 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 70.59 E-value: 8.64e-14
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
444-545 | 3.86e-12 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.42 E-value: 3.86e-12
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
351-558 | 2.81e-11 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 65.73 E-value: 2.81e-11
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
446-559 | 3.61e-07 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 51.33 E-value: 3.61e-07
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LRR_9 | pfam14580 | Leucine-rich repeat; |
468-545 | 1.03e-05 | |||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 46.30 E-value: 1.03e-05
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PPTA | pfam01239 | Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ... |
162-191 | 4.11e-05 | |||||
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family. Pssm-ID: 460128 [Multi-domain] Cd Length: 32 Bit Score: 40.70 E-value: 4.11e-05
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PPTA | pfam01239 | Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ... |
89-120 | 3.60e-04 | |||||
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family. Pssm-ID: 460128 [Multi-domain] Cd Length: 32 Bit Score: 38.00 E-value: 3.60e-04
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PPTA | pfam01239 | Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and ... |
208-238 | 6.25e-04 | |||||
Protein prenyltransferase alpha subunit repeat; Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family. Pssm-ID: 460128 [Multi-domain] Cd Length: 32 Bit Score: 37.23 E-value: 6.25e-04
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LRR_8 | pfam13855 | Leucine rich repeat; |
442-498 | 7.74e-04 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 7.74e-04
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LRR_8 | pfam13855 | Leucine rich repeat; |
488-545 | 1.33e-03 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.12 E-value: 1.33e-03
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
508-554 | 4.63e-03 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.30 E-value: 4.63e-03
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Blast search parameters | ||||
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