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Conserved domains on  [gi|538283534|gb|AGU99283|]
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DBY protein, partial [Mesoplodon carlhubbsi]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
1-24 6.44e-11

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd18051:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 249  Bit Score: 52.73  E-value: 6.44e-11
                         10        20
                 ....*....|....*....|....
gi 538283534   1 ENGRYGRRKQYPVSLVLAPTRELA 24
Cdd:cd18051   95 ESGYYGRRKQYPLALVLAPTRELA 118
 
Name Accession Description Interval E-value
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
1-24 6.44e-11

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 52.73  E-value: 6.44e-11
                         10        20
                 ....*....|....*....|....
gi 538283534   1 ENGRYGRRKQYPVSLVLAPTRELA 24
Cdd:cd18051   95 ESGYYGRRKQYPLALVLAPTRELA 118
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
8-24 5.52e-03

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 30.50  E-value: 5.52e-03
                         10
                 ....*....|....*..
gi 538283534   8 RKQYPVSLVLAPTRELA 24
Cdd:COG0513   68 RPRAPQALILAPTRELA 84
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
6-24 7.22e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 30.32  E-value: 7.22e-03
                         10
                 ....*....|....*....
gi 538283534   6 GRRKQYPVSLVLAPTRELA 24
Cdd:PRK04837  78 DRKVNQPRALIMAPTRELA 96
 
Name Accession Description Interval E-value
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
1-24 6.44e-11

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 52.73  E-value: 6.44e-11
                         10        20
                 ....*....|....*....|....
gi 538283534   1 ENGRYGRRKQYPVSLVLAPTRELA 24
Cdd:cd18051   95 ESGYYGRRKQYPLALVLAPTRELA 118
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
1-24 1.95e-07

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 43.24  E-value: 1.95e-07
                         10        20
                 ....*....|....*....|....
gi 538283534   1 ENGRYGRRKQYPVSLVLAPTRELA 24
Cdd:cd17967   68 PSVGRGRRKAYPSALILAPTRELA 91
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
1-24 1.91e-03

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 31.83  E-value: 1.91e-03
                         10        20
                 ....*....|....*....|....
gi 538283534   1 ENGRYGRRKqYPVSLVLAPTRELA 24
Cdd:cd17946   59 SNGVGGKQK-PLRALILTPTRELA 81
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
7-24 2.40e-03

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 31.64  E-value: 2.40e-03
                         10
                 ....*....|....*...
gi 538283534   7 RRKQYPVSLVLAPTRELA 24
Cdd:cd00268   58 KKGRGPQALVLAPTRELA 75
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
8-24 5.52e-03

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 30.50  E-value: 5.52e-03
                         10
                 ....*....|....*..
gi 538283534   8 RKQYPVSLVLAPTRELA 24
Cdd:COG0513   68 RPRAPQALILAPTRELA 84
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
6-24 7.22e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 30.32  E-value: 7.22e-03
                         10
                 ....*....|....*....
gi 538283534   6 GRRKQYPVSLVLAPTRELA 24
Cdd:PRK04837  78 DRKVNQPRALIMAPTRELA 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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