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Conserved domains on  [gi|537544587|ref|NP_001269289|]
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zinc finger protein 107 isoform c [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 1.16e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.16e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 537544587    3 PLTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-787 7.00e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 7.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 475 KPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKC--EECGKAFNRFSTLTKHKRIHTGEKPYKCEECGKAFNQ--SYQLTR 550
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 551 HKIVHTKEKLNkceEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFS 630
Cdd:COG5048  112 SSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 631 NITNHkiiyTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGKAF 710
Cdd:COG5048  189 SSNVS----TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 711 NLSSTLTAHKKIHTGE-------KPYKCEECGKAFNQSSNLTTHK--KIHTSE--KPYKCEE--CGKSFNQFSSLNIHKI 777
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 537544587 778 IHTGEKPYKC 787
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-545 4.09e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 167 NSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKC--EECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQA------- 237
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 238 -----------------SHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHK 300
Cdd:COG5048  112 ssssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 301 RIHAGEKPYKCKECGRA--FNISSNLNKQEKIHTGGKLNKC-EECDKAFNRSLKLTAHKKILMEEKPykceECGKVFNQF 377
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysIPSSSSDQNLENSSSSLPLTTNsQLSPKSLLSQSPSSLSSSDSSSSAS----ESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 378 STLTRHKIIHTGE-------KPYKCKECGKAFNQSSNLTEHK--KIHTAE--KSYKCEE--CGKAFNQHSNLINHRKIYS 444
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 445 GEKPYKC--EECGKAFNRSST-----LTRHKKIHTGEKPYKCE--ECDRAFSQSSNLTEHKKIHTGEKP--YKCEECGKA 513
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430
                 ....*....|....*....|....*....|..
gi 537544587 514 FNRFSTLTKHKRIHTGEKPYKCEECGKAFNQS 545
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 1.16e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.16e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 537544587    3 PLTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
4-43 2.29e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 2.29e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 537544587     4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL 40
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.01e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 2.01e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 537544587   4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-787 7.00e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 7.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 475 KPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKC--EECGKAFNRFSTLTKHKRIHTGEKPYKCEECGKAFNQ--SYQLTR 550
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 551 HKIVHTKEKLNkceEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFS 630
Cdd:COG5048  112 SSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 631 NITNHkiiyTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGKAF 710
Cdd:COG5048  189 SSNVS----TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 711 NLSSTLTAHKKIHTGE-------KPYKCEECGKAFNQSSNLTTHK--KIHTSE--KPYKCEE--CGKSFNQFSSLNIHKI 777
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 537544587 778 IHTGEKPYKC 787
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-545 4.09e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 167 NSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKC--EECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQA------- 237
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 238 -----------------SHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHK 300
Cdd:COG5048  112 ssssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 301 RIHAGEKPYKCKECGRA--FNISSNLNKQEKIHTGGKLNKC-EECDKAFNRSLKLTAHKKILMEEKPykceECGKVFNQF 377
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysIPSSSSDQNLENSSSSLPLTTNsQLSPKSLLSQSPSSLSSSDSSSSAS----ESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 378 STLTRHKIIHTGE-------KPYKCKECGKAFNQSSNLTEHK--KIHTAE--KSYKCEE--CGKAFNQHSNLINHRKIYS 444
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 445 GEKPYKC--EECGKAFNRSST-----LTRHKKIHTGEKPYKCE--ECDRAFSQSSNLTEHKKIHTGEKP--YKCEECGKA 513
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430
                 ....*....|....*....|....*....|..
gi 537544587 514 FNRFSTLTKHKRIHTGEKPYKCEECGKAFNQS 545
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
491-516 3.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 537544587  491 NLTEHKKIHTGEKPYKCEECGKAFNR 516
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
184-208 4.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.43e-04
                          10        20
                  ....*....|....*....|....*
gi 537544587  184 LTKHKRIHTGEKPYKCEECGKAFNQ 208
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 1.16e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 1.16e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 537544587    3 PLTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
4-43 2.29e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 2.29e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 537544587     4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL 40
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.01e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 2.01e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 537544587   4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-787 7.00e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 7.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 475 KPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKC--EECGKAFNRFSTLTKHKRIHTGEKPYKCEECGKAFNQ--SYQLTR 550
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 551 HKIVHTKEKLNkceEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFS 630
Cdd:COG5048  112 SSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 631 NITNHkiiyTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGKAF 710
Cdd:COG5048  189 SSNVS----TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 711 NLSSTLTAHKKIHTGE-------KPYKCEECGKAFNQSSNLTTHK--KIHTSE--KPYKCEE--CGKSFNQFSSLNIHKI 777
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 537544587 778 IHTGEKPYKC 787
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-692 2.54e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 2.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 223 KPNKCEECGKAFKQASHLTIHKIIHTGEKPY--KYEECGKVFSQSSHLTTQKILHTGENLYKC-KECGKAFNLFSNLTNH 299
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 300 KRIHAGEKPYKCKECGrafnISSNLNKQEKIHTGGKLNKCEECDKAFNRSLKltAHKKILMEEKPYKCEECGKVFNQFST 379
Cdd:COG5048  112 SSSSNSNDNNLLSSHS----LPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV--NTPQSNSLHPPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 380 LTRHKIIHTGEKPYKCKECGKAFNQSSNLTEHKKIHTAEKSYKCEECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFN 459
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 460 RSSTLTRHKKIHTGE-------KPYKCEECDRAFSQSSNLTEHK--KIHTGE--KPYKCEE--CGKAFNRFSTLTKHKRI 526
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 527 HTGEKPYKCeecgkafnqsyqltrhKIVHTKEKLNKCEEfGKAFKQSSHRTIHKIIHTGEKPYKCEEhgKVFNQSSNLTT 606
Cdd:COG5048  346 HTSISPAKE----------------KLLNSSSKFSPLLN-NEPPQSLQQYKDLKNDKKSETLSNSCI--RNFKRDSNLSL 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 607 QKIIHTGENLYKFeehgkafnlfsnitnhkiiytgekphKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSS 686
Cdd:COG5048  407 HIITHLSFRPYNC--------------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460


                 ....*.
gi 537544587 687 TLNRHK 692
Cdd:COG5048  461 LSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-798 4.72e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 4.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 348 RSLKLTAHKKILMEEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPYKC--KECGKAFNQSSNLTEHKKIHTAEKSYKCE- 424
Cdd:COG5048   17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSk 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 425 ECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHKKIHTGEKPYKCEECDRAFSQSSNLTEHKKIHTGEkp 504
Cdd:COG5048   97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 505 ykcEECGKAFNRFSTLTKHKRIHTGEKPYKCEECgkafNQSYQLTRHKIVHTKEklnkceefgkafKQSSHRTIHKIIHT 584
Cdd:COG5048  175 ---SLSKDPSSNLSLLISSNVSTSIPSSSENSPL----SSSYSIPSSSSDQNLE------------NSSSSLPLTTNSQL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 585 GEKPYKCEEHGKVFNQSSNLTTQKiihTGENLYKFEEHGKAFNLFSNITNHKIIYTgekPHKCEECGKAYNRFSNLTIHK 664
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASE---SPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 665 R--IHTGE--KPYQCAE--CGKAFNCSSTLNRHKIIHTGEKPYKCKEC-------GKAFNLSSTLTAHKKIHTGEKPYKC 731
Cdd:COG5048  310 RsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSET 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 537544587 732 E--ECGKAFNQSSNLTTHKKIHTSEKP--YKCEECGKSFNQFSSLNIHKIIHTGEKPYKCGDYGRAFNLSS 798
Cdd:COG5048  390 LsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-545 4.09e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 167 NSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKC--EECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQA------- 237
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 238 -----------------SHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHK 300
Cdd:COG5048  112 ssssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 301 RIHAGEKPYKCKECGRA--FNISSNLNKQEKIHTGGKLNKC-EECDKAFNRSLKLTAHKKILMEEKPykceECGKVFNQF 377
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysIPSSSSDQNLENSSSSLPLTTNsQLSPKSLLSQSPSSLSSSDSSSSAS----ESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 378 STLTRHKIIHTGE-------KPYKCKECGKAFNQSSNLTEHK--KIHTAE--KSYKCEE--CGKAFNQHSNLINHRKIYS 444
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 445 GEKPYKC--EECGKAFNRSST-----LTRHKKIHTGEKPYKCE--ECDRAFSQSSNLTEHKKIHTGEKP--YKCEECGKA 513
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430
                 ....*....|....*....|....*....|..
gi 537544587 514 FNRFSTLTKHKRIHTGEKPYKCEECGKAFNQS 545
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
447-816 3.09e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 447 KPYKCEECGKAFNRSSTLTRHKKIHTGEKPYKC--EECDRAFSQSSNLTEHKKIHTGEKPYkcEECGKAFNRFSTLTKHK 524
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 525 RIHTGE---KPYKCEECGKAFNQSYQLTRHKIVHTKEKLNKCEEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQS 601
Cdd:COG5048  110 LSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 602 SNLTT----------------QKIIHTGENLYKFEEHGKA--FNLFSNITNHKIIYTGEKPH----KCEECGKAYNRFSN 659
Cdd:COG5048  190 SNVSTsipsssensplsssysIPSSSSDQNLENSSSSLPLttNSQLSPKSLLSQSPSSLSSSdsssSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 660 LTIHKRIHTGE-------KPYQCAECGKAFNCSSTLNRHK--IIHTGE--KPYKCKE--CGKAFNLSSTLTAHKKIHTGE 726
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 727 KPYKC--EECGKAFNQSSNL---------TTHKKIHTSEKPYKCEECGKSFNQFSSLNIHKIIHTGEKPYKCGDYGRAFN 795
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNNeppqslqqyKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFN 429

                        410       420
                 ....*....|....*....|.
gi 537544587 796 LSSNLTTHKKIHTGEKPYKCE 816
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
491-516 3.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 537544587  491 NLTEHKKIHTGEKPYKCEECGKAFNR 516
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
520-544 4.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.43e-04
                          10        20
                  ....*....|....*....|....*
gi 537544587  520 LTKHKRIHTGEKPYKCEECGKAFNQ 544
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
184-208 4.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.43e-04
                          10        20
                  ....*....|....*....|....*
gi 537544587  184 LTKHKRIHTGEKPYKCEECGKAFNQ 208
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-404 5.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.95e-04
                          10        20
                  ....*....|....*....|....*
gi 537544587  380 LTRHKIIHTGEKPYKCKECGKAFNQ 404
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
688-711 6.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.96e-04
                          10        20
                  ....*....|....*....|....
gi 537544587  688 LNRHKIIHTGEKPYKCKECGKAFN 711
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-488 7.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.03e-04
                          10        20
                  ....*....|....*....|....*
gi 537544587  464 LTRHKKIHTGEKPYKCEECDRAFSQ 488
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
743-768 9.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 537544587  743 NLTTHKKIHTSEKPYKCEECGKSFNQ 768
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
659-684 1.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 537544587  659 NLTIHKRIHTGEKPYQCAECGKAFNC 684
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 389-469 1.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 389 GEKPYKCK--ECGKAFNQSSNLTEHKKiHTaeksykceECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTR 466
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 537544587 467 HKK 469
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
716-740 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*
gi 537544587  716 LTAHKKIHTGEKPYKCEECGKAFNQ 740
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 473-552 2.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 473 GEKPYKCE--ECDRAFSQSSNLTEHKKiHTGEKPYKCEECGKafnrfstlTKHKRIHTGEKPYKCEECGKAFNQSYQLTR 550
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 537544587 551 HK 552
Cdd:COG5189  417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
741-819 2.37e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 741 SSNLTTHKKIHTSEKPYKCEECGKSFNQFSSLNIHKIIHTGEKPYKCGDYGRAFNLS--SNLTTHKKIHTGEKPYKCEYG 818
Cdd:COG5048   18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKS 97


                 .
gi 537544587 819 K 819
Cdd:COG5048   98 L 98
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 725-776 2.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 537544587 725 GEKPYKCE--ECGKAFNQSSNLTTHKK-------------------IHTSEKPYKCEECGKSFNQFSSLNIHK 776
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 445-524 2.50e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 445 GEKPYKCE--ECGKAFNRSSTLTRHKKiHTGEKPYKCEECDRafsqssnlTEHKKIHTGEKPYKCEECGKAFNRFSTLTK 522
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 537544587 523 HK 524
Cdd:COG5189  417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
139-303 3.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 139 KHFKCKECSKSFCVLSQLTQHRR--IHTRVNSYKCEE----CGKAFNWFSTLTKHKRIHTGEKPYKCEecgkafnqssqL 212
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEK-----------L 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544587 213 TRHKIIHTEEKPNkceecgkafKQASHLTIHKIIHTGEKPYK-YEECGKVFSQSSHLTTQKILHTGEN--LYKCKECGKA 289
Cdd:COG5048  357 LNSSSKFSPLLNN---------EPPQSLQQYKDLKNDKKSETlSNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKS 427

                        170
                 ....*....|....
gi 537544587 290 FNLFSNLTNHKRIH 303
Cdd:COG5048  428 FNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 5.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 537544587  407 NLTEHKKIHTAEKSYKCEECGKAFNQ 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-319 7.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.88e-03
                          10        20
                  ....*....|....*....|....*
gi 537544587  295 NLTNHKRIHAGEKPYKCKECGRAFN 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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