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Conserved domains on  [gi|534533913|gb|EFE46213|]
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PTS system, glucose subfamily, IIA component [Erysipelotrichaceae bacterium 5_2_54FAA]

Protein Classification

PTS glucose transporter subunit IIA( domain architecture ID 10005511)

PTS glucose transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming glucose substrates concomitantly with their translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
7-155 1.16e-42

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


:

Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 138.72  E-value: 1.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   7 PKNQKIEVYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVD 85
Cdd:COG2190    1 KKSKTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDgLEVLIHIGID 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 534533913  86 TCMYKGEGLQVLTTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIFMDCES-ERIQLYSENLVTQGKTAIA 155
Cdd:COG2190   81 TVKLNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEyKSVELTKSGQVKAGDPLLT 151
 
Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
7-155 1.16e-42

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 138.72  E-value: 1.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   7 PKNQKIEVYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVD 85
Cdd:COG2190    1 KKSKTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDgLEVLIHIGID 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 534533913  86 TCMYKGEGLQVLTTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIFMDCES-ERIQLYSENLVTQGKTAIA 155
Cdd:COG2190   81 TVKLNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEyKSVELTKSGQVKAGDPLLT 151
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
12-131 1.82e-40

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 132.12  E-value: 1.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   12 IEVYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVDTCMYK 90
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDgVEVLIHIGIDTVKLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 534533913   91 GEGLQVLTTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIF 131
Cdd:pfam00358  81 GEGFESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 14-131 4.36e-32

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 110.80  E-value: 4.36e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   14 VYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVDTCMYKGE 92
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNgVEILIHIGIDTVKLNGE 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 534533913   93 GLQVLTTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIF 131
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVV 119
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 19-131 4.68e-30

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 105.83  E-value: 4.68e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913  19 SGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVDTCMYKGEGLQVL 97
Cdd:cd00210    6 TGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSgVEILIHIGIDTVKLNGEGFTSH 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 534533913  98 TTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIF 131
Cdd:cd00210   86 VEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIV 119
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 11-157 5.77e-24

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 91.57  E-value: 5.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913  11 KIEVYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAV-IVKNESVNILVHVGVDTCMY 89
Cdd:PRK09439  20 TIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFsIESDSGVELFVHFGIDTVEL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913  90 KGEGLQVLTTKNAEVKVGDPLIKVDRQFFKEK--NINTDTILIFMDCESERIQLYSEnlVTQGKTAIASI 157
Cdd:PRK09439 100 KGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKakSTLTPVVISNMDEIKELIKLSGS--VTAGETPVIRV 167
 
Name Accession Description Interval E-value
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
7-155 1.16e-42

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 138.72  E-value: 1.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   7 PKNQKIEVYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVD 85
Cdd:COG2190    1 KKSKTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDgLEVLIHIGID 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 534533913  86 TCMYKGEGLQVLTTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIFMDCES-ERIQLYSENLVTQGKTAIA 155
Cdd:COG2190   81 TVKLNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEyKSVELTKSGQVKAGDPLLT 151
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
12-131 1.82e-40

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 132.12  E-value: 1.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   12 IEVYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVDTCMYK 90
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDgVEVLIHIGIDTVKLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 534533913   91 GEGLQVLTTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIF 131
Cdd:pfam00358  81 GEGFESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 14-131 4.36e-32

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 110.80  E-value: 4.36e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   14 VYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVDTCMYKGE 92
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNgVEILIHIGIDTVKLNGE 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 534533913   93 GLQVLTTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIF 131
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVV 119
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 19-131 4.68e-30

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 105.83  E-value: 4.68e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913  19 SGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVDTCMYKGEGLQVL 97
Cdd:cd00210    6 TGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSgVEILIHIGIDTVKLNGEGFTSH 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 534533913  98 TTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIF 131
Cdd:cd00210   86 VEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIV 119
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 11-157 5.77e-24

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 91.57  E-value: 5.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913  11 KIEVYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAV-IVKNESVNILVHVGVDTCMY 89
Cdd:PRK09439  20 TIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFsIESDSGVELFVHFGIDTVEL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913  90 KGEGLQVLTTKNAEVKVGDPLIKVDRQFFKEK--NINTDTILIFMDCESERIQLYSEnlVTQGKTAIASI 157
Cdd:PRK09439 100 KGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKakSTLTPVVISNMDEIKELIKLSGS--VTAGETPVIRV 167
PRK10255 PRK10255
PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional
 7-120 5.03e-20

PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional


Pssm-ID: 182338 [Multi-domain]  Cd Length: 648  Bit Score: 85.69  E-value: 5.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   7 PKNQKIEVYSSN-SGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGV 84
Cdd:PRK10255 493 PNAVSIAELVSPiTGDVVALDQVPDEAFASKAVGDGVAVKPTDKIVVSPAAGTIVKIFNTNHAFCLETEKgAEIVVHMGI 572

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 534533913  85 DTCMYKGEGLQVLTTKNAEVKVGDPLIKVDRQFFKE 120
Cdd:PRK10255 573 DTVALEGKGFKRLVEEGAQVSAGQPILEMDLDYLNA 608
PRK09824 PRK09824
PTS system beta-glucoside-specific transporter subunits IIABC; Provisional
 9-138 1.36e-17

PTS system beta-glucoside-specific transporter subunits IIABC; Provisional


Pssm-ID: 236627 [Multi-domain]  Cd Length: 627  Bit Score: 78.60  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 534533913   9 NQKIEVYSSNSGCLYALEQVKDDIFSTKMMGEGIAIKTDDAYVFSPISGTIEMIADTKHAVIVKNES-VNILVHVGVDTC 87
Cdd:PRK09824 476 PEQGGICSPMTGEVVPLEQVADTTFASGLLGKGIAILPSVGEVRSPVAGRVASLFATLHAIGLESDDgVEVLIHVGIDTV 555

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 534533913  88 MYKGEGLQVLTTKNAEVKVGDPLIKVDRQFFKEKNINTDTILIFMDCESER 138
Cdd:PRK09824 556 KLDGKFFTAHVNVGDKVNTGDLLIEFDIPAIREAGYDLTTPVLISNSDDYT 606
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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