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Conserved domains on  [gi|533240834|ref|YP_008475644|]
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hypothetical protein lmo2644a [Listeria monocytogenes EGD-e]

Protein Classification

SIS domain-containing protein( domain architecture ID 10011877)

SIS (sugar isomerase) domain-containing protein may regulate the expression of genes involved in synthesis of phosphosugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK02947 PRK02947
sugar isomerase domain-containing protein;
1-244 2.15e-137

sugar isomerase domain-containing protein;


:

Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 385.76  E-value: 2.15e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834   1 MINNYVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAAIHPILHEPLMLHEGA 80
Cdd:PRK02947   3 MIDEYFDAVIELLERVRETQAEAIEKAADLIADSIRNGGLIYVFGTGHSHILAEEVFYRAGGLAPVNPILEPSLMLHEGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  81 AASSVLERKNDYAKTFMVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSASQKSRHKSGKRLSDTG 160
Cdd:PRK02947  83 VASSYLERVEGYAKAILDRYDIRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTSLAYSASVASRHSSGKRLAEVA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834 161 DIVIDNGAVKGDAVLKSANFDIAFAPTSTVTGAVILQSIFAEAIEKMVNDNFTPPVFISGNVENADAHNQALVDKYKERI 240
Cdd:PRK02947 163 DVVLDNGAPKGDAVLEIPGLEAPVGPVSTVVGAAILNAIFAEVAERLVERGITPPVFLSANVDGGDEHNQALVEKYRDRI 242


                 ....
gi 533240834 241 PLLG 244
Cdd:PRK02947 243 PRLA 246
 
Name Accession Description Interval E-value
PRK02947 PRK02947
sugar isomerase domain-containing protein;
1-244 2.15e-137

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 385.76  E-value: 2.15e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834   1 MINNYVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAAIHPILHEPLMLHEGA 80
Cdd:PRK02947   3 MIDEYFDAVIELLERVRETQAEAIEKAADLIADSIRNGGLIYVFGTGHSHILAEEVFYRAGGLAPVNPILEPSLMLHEGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  81 AASSVLERKNDYAKTFMVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSASQKSRHKSGKRLSDTG 160
Cdd:PRK02947  83 VASSYLERVEGYAKAILDRYDIRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTSLAYSASVASRHSSGKRLAEVA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834 161 DIVIDNGAVKGDAVLKSANFDIAFAPTSTVTGAVILQSIFAEAIEKMVNDNFTPPVFISGNVENADAHNQALVDKYKERI 240
Cdd:PRK02947 163 DVVLDNGAPKGDAVLEIPGLEAPVGPVSTVVGAAILNAIFAEVAERLVERGITPPVFLSANVDGGDEHNQALVEKYRDRI 242


                 ....
gi 533240834 241 PLLG 244
Cdd:PRK02947 243 PRLA 246
COG4821 COG4821
Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain ...
 1-244 1.34e-121

Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain [General function prediction only];


Pssm-ID: 443849 [Multi-domain]  Cd Length: 250  Bit Score: 346.03  E-value: 1.34e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834   1 MINNYVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAAIHPILHEPLMLHEGA 80
Cdd:COG4821    4 LASQYLDEVRELLDRIEETQAEAIEKAADLIADSIAAGGLVHLFGTGHSHLLAEEVFYRAGGLVGFNPILDPSLMLHNGA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  81 AA---SSVLERKNDYAKTFMVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSASQKSRHKSGKRLS 157
Cdd:COG4821   84 PGvlqSSFLERVEGYAEIILENYPIRPGDVLIVISNSGRNAVPIEMALEAKERGLKVIAITSLEHSKAVPSRHSSGKRLF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834 158 DTGDIVIDNGAVKGDAVLKSANFDIAFAPTSTVTGAVILQSIFAEAIEKMVNDNFTPPVFISGNVENADAHNQALVDKYK 237
Cdd:COG4821  164 ELADVVIDNCVPYGDAVLPLEGLDTKVGPVSTVAGAFILNSLVAEVAELLAERGIEPPVFRSANVPGGDEHNEALLEKYR 243


                 ....*..
gi 533240834 238 ERIPLLG 244
Cdd:COG4821  244 GRIRRLA 250
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 5-139 2.59e-45

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 148.13  E-value: 2.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834    5 YVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAAIHPILHEPLMLHEGAAA-- 82
Cdd:pfam13580   2 YLDEVRALLERVVETQADAIEKAADLIAASLANGGKVYAFGTGHSAAPAEELFARAGGLAGFEPILLPALALHTDASAti 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 533240834   83 SSVLERKNDYAKTFMVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITS 139
Cdd:pfam13580  82 STALERDEGYARQILALYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALTS 138
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 26-202 2.38e-18

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 78.42  E-value: 2.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  26 EAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAaIHPILHeplmlhegaaassvlerkNDYAKTFMVEEDIRPG 105
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLG-KPVVLL------------------SDPHLQLMSAANLTPG 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834 106 DIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSasqksrhksgkRLSDTGDIVIDNGAVKGDavlksanfDIAFA 185
Cdd:cd05013   62 DVVIAISFSGETKETVEAAEIAKERGAKVIAITDSANS-----------PLAKLADIVLLVSSEEGD--------FRSSA 122

                        170
                 ....*....|....*..
gi 533240834 186 PTSTVTGAVILQSIFAE 202
Cdd:cd05013  123 FSSRIAQLALIDALFLA 139
 
Name Accession Description Interval E-value
PRK02947 PRK02947
sugar isomerase domain-containing protein;
1-244 2.15e-137

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 385.76  E-value: 2.15e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834   1 MINNYVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAAIHPILHEPLMLHEGA 80
Cdd:PRK02947   3 MIDEYFDAVIELLERVRETQAEAIEKAADLIADSIRNGGLIYVFGTGHSHILAEEVFYRAGGLAPVNPILEPSLMLHEGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  81 AASSVLERKNDYAKTFMVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSASQKSRHKSGKRLSDTG 160
Cdd:PRK02947  83 VASSYLERVEGYAKAILDRYDIRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTSLAYSASVASRHSSGKRLAEVA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834 161 DIVIDNGAVKGDAVLKSANFDIAFAPTSTVTGAVILQSIFAEAIEKMVNDNFTPPVFISGNVENADAHNQALVDKYKERI 240
Cdd:PRK02947 163 DVVLDNGAPKGDAVLEIPGLEAPVGPVSTVVGAAILNAIFAEVAERLVERGITPPVFLSANVDGGDEHNQALVEKYRDRI 242


                 ....
gi 533240834 241 PLLG 244
Cdd:PRK02947 243 PRLA 246
COG4821 COG4821
Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain ...
 1-244 1.34e-121

Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain [General function prediction only];


Pssm-ID: 443849 [Multi-domain]  Cd Length: 250  Bit Score: 346.03  E-value: 1.34e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834   1 MINNYVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAAIHPILHEPLMLHEGA 80
Cdd:COG4821    4 LASQYLDEVRELLDRIEETQAEAIEKAADLIADSIAAGGLVHLFGTGHSHLLAEEVFYRAGGLVGFNPILDPSLMLHNGA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  81 AA---SSVLERKNDYAKTFMVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSASQKSRHKSGKRLS 157
Cdd:COG4821   84 PGvlqSSFLERVEGYAEIILENYPIRPGDVLIVISNSGRNAVPIEMALEAKERGLKVIAITSLEHSKAVPSRHSSGKRLF 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834 158 DTGDIVIDNGAVKGDAVLKSANFDIAFAPTSTVTGAVILQSIFAEAIEKMVNDNFTPPVFISGNVENADAHNQALVDKYK 237
Cdd:COG4821  164 ELADVVIDNCVPYGDAVLPLEGLDTKVGPVSTVAGAFILNSLVAEVAELLAERGIEPPVFRSANVPGGDEHNEALLEKYR 243


                 ....*..
gi 533240834 238 ERIPLLG 244
Cdd:COG4821  244 GRIRRLA 250
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 5-139 2.59e-45

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 148.13  E-value: 2.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834    5 YVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAAIHPILHEPLMLHEGAAA-- 82
Cdd:pfam13580   2 YLDEVRALLERVVETQADAIEKAADLIAASLANGGKVYAFGTGHSAAPAEELFARAGGLAGFEPILLPALALHTDASAti 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 533240834   83 SSVLERKNDYAKTFMVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITS 139
Cdd:pfam13580  82 STALERDEGYARQILALYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALTS 138
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 26-202 2.38e-18

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 78.42  E-value: 2.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  26 EAGAKVAKSIENDGVIHLFGCGHSHILTEEVFYRAGGLAaIHPILHeplmlhegaaassvlerkNDYAKTFMVEEDIRPG 105
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLG-KPVVLL------------------SDPHLQLMSAANLTPG 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834 106 DIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSasqksrhksgkRLSDTGDIVIDNGAVKGDavlksanfDIAFA 185
Cdd:cd05013   62 DVVIAISFSGETKETVEAAEIAKERGAKVIAITDSANS-----------PLAKLADIVLLVSSEEGD--------FRSSA 122

                        170
                 ....*....|....*..
gi 533240834 186 PTSTVTGAVILQSIFAE 202
Cdd:cd05013  123 FSSRIAQLALIDALFLA 139
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 11-164 8.64e-10

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 56.36  E-value: 8.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  11 RLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHSHI----LTEEVFYRAG----GLAAIhpilheplMLHEGAAA 82
Cdd:cd05006    6 QLKEALLELLAEAIEQAAQLLAEALLNGGKILICGNGGSAAdaqhFAAELVKRFEkerpGLPAI--------ALTTDTSI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  83 SSVLERKNDYAKTF--MVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSlqysasqksrhKSGKRLSDTG 160
Cdd:cd05006   78 LTAIANDYGYEEVFsrQVEALGQPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTG-----------RDGGKLLELA 146


                 ....
gi 533240834 161 DIVI 164
Cdd:cd05006  147 DIEI 150
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 12-143 4.14e-08

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 52.62  E-value: 4.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  12 LLENILDNEADYVKEAGA--------KVAKSIENDGVIHLFGCGHSHILTEEVFYRAgglaaihpilhepLMLHEGAAAS 83
Cdd:COG1737  100 ILAKVLEAEIANLEETLElldeealeRAVDLLAKARRIYIFGVGASAPVAEDLAYKL-------------LRLGKNVVLL 166

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  84 SvlerkNDYAKTFMVEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYS 143
Cdd:COG1737  167 D-----GDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLS 221
GmhA COG0279
Phosphoheptose isomerase [Carbohydrate transport and metabolism];
2-164 2.46e-07

Phosphoheptose isomerase [Carbohydrate transport and metabolism];


Pssm-ID: 440048 [Multi-domain]  Cd Length: 189  Bit Score: 49.34  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834   2 INNYVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHS-----HILTEEV--FYRAG-GLAAIhpilhep 73
Cdd:COG0279    5 IKQYFEESIEALQALAEALAEAIEAAAELLAEALLNGGKILVCGNGGSaadaqHFAAELVgrFERERpGLPAI------- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  74 lMLH-EGAAASSVLerkNDYAktFmveEDI---------RPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSlqys 143
Cdd:COG0279   78 -ALTtDTSVLTAIA---NDYG--Y---DEVfarqvealgRPGDVLLAISTSGNSPNVLRALEAARERGMTTIALTG---- 144

                        170       180
                 ....*....|....*....|.
gi 533240834 144 asqksrhKSGKRLSDTGDIVI 164
Cdd:COG0279  145 -------RDGGKLAGLADIEI 158
PRK13937 PRK13937
phosphoheptose isomerase; Provisional
 1-135 5.44e-05

phosphoheptose isomerase; Provisional


Pssm-ID: 184408 [Multi-domain]  Cd Length: 188  Bit Score: 42.54  E-value: 5.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834   1 MINNYVDITVRLLENILDNEADYVKEAGAKVAKSIENDGVIHLFGCGHS-----HILTEEV----FYRAGgLAAIhpilh 71
Cdd:PRK13937   1 LITKHFRESQAVMEAFLESLLEAIAKVAEALIEALANGGKILLCGNGGSaadaqHIAAELVgrfkKERPA-LPAI----- 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 533240834  72 eplmlhegaaA----SSVLER-KNDYAKTFM----VEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVI 135
Cdd:PRK13937  75 ----------AlttdTSALTAiGNDYGFERVfsrqVEALGRPGDVLIGISTSGNSPNVLAALEKARELGMKTI 137
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
41-139 1.65e-04

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 42.60  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  41 IHLFGCGHSHILTEEVFYRAGGLAaIHPILHEPLMLHEGAAASsvlerkndyaktfmveedIRPGDIMIVLSTSGRNPVP 120
Cdd:PRK14101 471 IEFYGLGNSNIVAQDAHYKFFRFG-IPTIAYGDLYMQAASAAL------------------LGKGDVIVAVSKSGRAPEL 531

                         90
                 ....*....|....*....
gi 533240834 121 IDVAEIAREKGAFVIVITS 139
Cdd:PRK14101 532 LRVLDVAMQAGAKVIAITS 550
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 102-139 1.83e-04

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 41.02  E-value: 1.83e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 533240834 102 IRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITS 139
Cdd:cd05005   73 IGPGDLLIAISGSGETSSVVNAAEKAKKAGAKVVLITS 110
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
98-150 4.79e-04

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 40.45  E-value: 4.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 533240834  98 VEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSASQKSRH 150
Cdd:PRK15482 176 VSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAH 228
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 105-139 5.62e-04

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 40.36  E-value: 5.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 533240834 105 GDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITS 139
Cdd:PRK11302 176 GDVVVLISHTGRTKSLVELAQLARENGATVIAITS 210
PRK13938 PRK13938
phosphoheptose isomerase; Provisional
 67-165 5.66e-04

phosphoheptose isomerase; Provisional


Pssm-ID: 139997 [Multi-domain]  Cd Length: 196  Bit Score: 39.72  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  67 HPILHEPLM----LHEGAAASSVLERKNDYAKTFM--VEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSl 140
Cdd:PRK13938  70 HLIFDRPPLgaeaLHANSSHLTAVANDYDYDTVFAraLEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTG- 148

                         90       100
                 ....*....|....*....|....*
gi 533240834 141 qysasqksrhKSGKRLSDTGDIVID 165
Cdd:PRK13938 149 ----------ESGGQLAEFADFLIN 163
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 102-196 6.41e-04

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 38.68  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834 102 IRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSLQYSAsqksrhksgkrLSDTGDIVIDNGAVKGDAVLKsanfd 181
Cdd:cd05014   45 VTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNST-----------LAKLSDVVLDLPVEEEACPLG----- 108

                         90
                 ....*....|....*
gi 533240834 182 iaFAPTSTVTGAVIL 196
Cdd:cd05014  109 --LAPTTSTTAMLAL 121
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 102-138 1.18e-03

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 36.97  E-value: 1.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 533240834 102 IRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVIT 138
Cdd:cd04795   45 LRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAIT 81
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 102-139 2.49e-03

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 36.89  E-value: 2.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 533240834  102 IRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITS 139
Cdd:pfam01380  51 VDEDDLVIAISYSGETKDLLAAAELAKARGAKIIAITD 88
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
30-138 4.31e-03

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 37.82  E-value: 4.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  30 KVAKSIENDGVIHLFGCGHSHILTEEV---FYRAGGLAAIHPILHEPLMlhegaaASSVLerkndyaktfmveediRPGD 106
Cdd:PRK11337 132 RAARFFYQARQRDLYGAGGSAAIARDVqhkFLRIGVRCQAYDDAHIMLM------SAALL----------------QEGD 189

                         90       100       110
                 ....*....|....*....|....*....|..
gi 533240834 107 IMIVLSTSGRNPVPIDVAEIAREKGAFVIVIT 138
Cdd:PRK11337 190 VVLVVSHSGRTSDVIEAVELAKKNGAKIICIT 221
gmhA PRK00414
D-sedoheptulose 7-phosphate isomerase;
1-164 5.54e-03

D-sedoheptulose 7-phosphate isomerase;


Pssm-ID: 179012 [Multi-domain]  Cd Length: 192  Bit Score: 36.64  E-value: 5.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834   1 MINNYVDITVRLLENILDNEADY--VKEAGAKVAKSIENDGVIHLFGCGHSHI----LTEEVF--YRAG--GLAAIhpIL 70
Cdd:PRK00414   5 LIRNELNEAAETLANFLKDDANIhaIQRAAVLIADSFKAGGKVLSCGNGGSHCdamhFAEELTgrYRENrpGYPAI--AI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 533240834  71 HEPLMLhegaaaSSVlerKNDYAKTFM----VEEDIRPGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITSlqysasq 146
Cdd:PRK00414  83 SDVSHL------SCV---SNDFGYDYVfsryVEAVGREGDVLLGISTSGNSGNIIKAIEAARAKGMKVITLTG------- 146

                        170
                 ....*....|....*...
gi 533240834 147 ksrhKSGKRLSDTGDIVI 164
Cdd:PRK00414 147 ----KDGGKMAGLADIEI 160
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
 104-139 7.05e-03

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 36.73  E-value: 7.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 533240834 104 PGDIMIVLSTSGRNPVPIDVAEIAREKGAFVIVITS 139
Cdd:cd05007  118 ERDVVIGIAASGRTPYVLGALRYARARGALTIGIAC 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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