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Conserved domains on  [gi|532694091|gb|AGU00637|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Bos taurus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 2.49e-94

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 271.29  E-value: 2.49e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   1 MMLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091  81 EIWLSNKAVLGAFVTGLLMEFFMVYYVLKDKEVEVVFEFNGLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 532694091 161 LLIGVVVIMEITRGN 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 2.49e-94

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 271.29  E-value: 2.49e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   1 MMLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091  81 EIWLSNKAVLGAFVTGLLMEFFMVYYVLKDKEVEVVFEFNGLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 532694091 161 LLIGVVVIMEITRGN 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-171 8.95e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 64.83  E-value: 8.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   18 VGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYPEIWLSNKAVLGAFVTGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532694091   98 LMEFFMVYYVLKDKEVEVVfefnglgdwviyDTGDSGFFSEEAMGIaALYSYGTWLVIVTGWSLLIGVVVIMEI 171
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAA------------AAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 2.49e-94

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 271.29  E-value: 2.49e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   1 MMLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091  81 EIWLSNKAVLGAFVTGLLMEFFMVYYVLKDKEVEVVFEFNGLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 532694091 161 LLIGVVVIMEITRGN 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 2-174 1.01e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 117.16  E-value: 1.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   2 MLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYPE 81
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091  82 IWLSNkAVLGafvtgllmefFMVYYVLKDKEVEVVFefngLGDW------VIYDTGDSGFFSEEAMGIAALYSYGTWLVI 155
Cdd:MTH00138  81 SWGSW-SVLG----------YVVGYLVGVVLAAGLF----WGGWyegswvVVDELKEFSVLRGDVGGVALMYSSGGGMLV 145

                        170
                 ....*....|....*....
gi 532694091 156 VTGWSLLIGVVVIMEITRG 174
Cdd:MTH00138 146 ICAWVLLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 2-174 1.67e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 106.47  E-value: 1.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   2 MLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYPE 81
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091  82 IWLSNKAVLGAFVTGLLMeffMVYYVLKDKEVEVVFEFNGLGDWViydtgdsGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00065  81 AWGSWSVLVYVLFYLLLL---IVGYILFGCNFSLEFLFTNYDTEF-------SVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|...
gi 532694091 162 LIGVVVIMEITRG 174
Cdd:MTH00065 151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 2-174 9.77e-25

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 94.04  E-value: 9.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   2 MLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYPE 81
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091  82 IWLSNKAVLGAFVTGLLMEFFMVYYVlkdkeveVVFEFNGLGDWVIyDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVG-------GLWGMEGVGVVTV-DSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|...
gi 532694091 162 LIGVVVIMEITRG 174
Cdd:MTH00115 153 LLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 2-174 6.11e-17

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 73.87  E-value: 6.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   2 MLYIVFILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYPE 81
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091  82 IWLSNKAVLGAFVTGLLMEFFMVYYvlkdkevevvfefnGLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYF--------------YGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|...
gi 532694091 162 LIGVVVIMEITRG 174
Cdd:MTH00214 147 FLVLFVVLELVRG 159
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-171 8.95e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 64.83  E-value: 8.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   18 VGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYPEIWLSNKAVLGAFVTGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 532694091   98 LMEFFMVYYVLKDKEVEVVfefnglgdwviyDTGDSGFFSEEAMGIaALYSYGTWLVIVTGWSLLIGVVVIMEI 171
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAA------------AAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-175 1.35e-13

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 64.93  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   1 MMLYIVFILsVIFVMGFVGFSSkpSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEQYP 80
Cdd:MTH00045   1 MVFYLFLIL-MLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091  81 EIWLSNKAVLGAFVTGLLmeffmvyyvlkdkeveVVFEFNGLGDWVIYDTGDSGFFSEeaMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00045  78 SVSNLGEVLVLSLLLSLW----------------VFISFDNFLELSNNNWSLVSLSDL--VGSSELYNSGGLYLLLGGFI 139

                        170
                 ....*....|....*
gi 532694091 161 LLIGVVVIMEITRGN 175
Cdd:MTH00045 140 LLVALVVALVISFGH 154
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-128 8.99e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 37.94  E-value: 8.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   1 MMLYIVFILSVIFVMGFVGFSSkpsPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMATEqyp 80
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSKQ---PLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLSPN--- 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 532694091  81 EIWLSNKAVLGAFVT--GLLMEFFMVYYVLKDKEVEVVFEFNGLGDWVIY 128
Cdd:MTH00152  75 PLFGSNFKFVFFSLTlfGFLGLFFFFLYLYSSGGLSLSSLFDGSSGSLSF 124
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 8-112 1.40e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 37.29  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532694091   8 ILSVIFVMGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMMVVFGYTTAMAteqyPEIWLSNK 87
Cdd:MTH00212   5 LLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS----PNEHLFFK 80

                         90       100
                 ....*....|....*....|....*
gi 532694091  88 AVLGAFVTGLLMEFFMVYYVLKDKE 112
Cdd:MTH00212  81 KYFKGFGMILISLNLYLLLMTLGSS 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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