|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
377-824 |
0e+00 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 756.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 377 KFSYIPATSEDKSKMLKVVGLNSVDELFSDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENLSLEDLTCFLGAGAYDH 456
Cdd:PRK00451 1 GMPYIPHTEEDIREMLDAIGVKSIDELFADIPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEEYPSFLGAGAYDH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 457 YIPSIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANASMYDGATAAIEACIMAMNQTRKSKIVVS 536
Cdd:PRK00451 81 YIPAVVDHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMICELTGMDVANASMYDGATALAEAALMAVRITKRKKVLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 537 KTIHPETLSVLRTYLQYKDCEIVEIDFCNeyGTTDIEKLKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLIM 616
Cdd:PRK00451 161 GAVHPEYREVLKTYLKGQGIEVVEVPYED--GVTDLEALEAAVDDDTAAVVVQYPNFFGVIEDLEEIAEIAHAGGALFIV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 617 SVDPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQHV 696
Cdd:PRK00451 239 GVDPVSLGLLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 697 RREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHYTYNKLVQTGKYKPiFKGKFFKEFAVQGNLNIETIN 776
Cdd:PRK00451 319 RREKATSNICTNQALNALAAAIYMSLLGPEGLRELAEQNHQKAHYLAERLAEIGGVEL-FDGPFFNEFVVRLPKPAEEVN 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 531106561 777 DKLLEENILGGYNLEYNYPELKNSTLLCVTEKRSKEEIDKLVGIMEGL 824
Cdd:PRK00451 398 EALLEKGILGGYDLGRYYPELGNHLLVCVTEKRTKEDIDALVAALGEV 445
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
380-823 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 704.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 380 YIPATSEDKSKMLKVVGLNSVDELFSDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENlslEDLTCFLGAGAYDHYIP 459
Cdd:COG0403 7 YIPPTEEDRAEMLAAIGVDSLDELFDDIPAEIRLKRPLDLPEALSEAELLRHLRALAAKN---KVLTSFIGAGYYDHYVP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 460 SIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANASMYDGATAAIEACIMAMNQTRKS-KIVVSKT 538
Cdd:COG0403 84 AVVRNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTKRSnKVLVSED 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 539 IHPETLSVLRTYLQYKDCEIVEIDFCNeyGTTDIEKLKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLIMSV 618
Cdd:COG0403 164 VHPQTRAVLKTYAEPLGIEVVEVPDED--GVTDLEALKALLDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALVIVAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 619 DPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQHVRR 698
Cdd:COG0403 242 DPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQHIRR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 699 EKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHYTYNKLVQTGkYKPIFKGKFFKEFAVQGNLNIETINDK 778
Cdd:COG0403 322 EKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALG-VEVPFNGPFFDEFVVRLPKPAAEINAA 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 531106561 779 LLEENILGGYNLEYnypELKNSTLLCVTEKRSKEEIDKLVGIMEG 823
Cdd:COG0403 401 LLEKGILGGLNLRR---VDDDTLLVAVTETTTKEDIDALVEALAE 442
|
|
| gcvT |
PRK00389 |
glycine cleavage system aminomethyltransferase GcvT; |
3-366 |
0e+00 |
|
glycine cleavage system aminomethyltransferase GcvT;
Pssm-ID: 234742 [Multi-domain] Cd Length: 359 Bit Score: 545.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 3 ELKRVSLYNIHKELGAKLVEFAGWEMPLEYEGINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKIN 82
Cdd:PRK00389 1 MLKRTPLYDLHVALGAKMVDFGGWEMPVQYGSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKLKPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 83 DIIYTPMCYENGGVVDDLLIYKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQKIT 162
Cdd:PRK00389 81 KAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVVNAANREKDLAWIKSHAAGFGVEVTDRSDDLAMIAVQGPKAREKLQKLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 163 DIDLNSIKFYKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGEdicPAGLGCRDTLRFEAALPLY 242
Cdd:PRK00389 161 DADLSELKPFFGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEAGVK---PCGLGARDTLRLEAGMPLY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 243 GHEINEHISPIEGGLSIFVKTNKES-FIGKSILSKEKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKTVGFVTTGCASPT 321
Cdd:PRK00389 238 GQDMDETITPLEAGLGWTVKLEEKRdFIGREALEAQKEAGVERKLVGLELEERGIPRHGYPVLADGEEIGEVTSGTFSPT 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 531106561 322 TGKILGMGIIDSEYakvGNEIGIAIRKKVVPAVIVKKPFYKKQYK 366
Cdd:PRK00389 318 LGKSIALAYVPAGV---GDEVEVEIRGKQVPAKVVKPPFVRRGKR 359
|
|
| GcvT |
COG0404 |
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ... |
1-367 |
2.06e-180 |
|
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440173 [Multi-domain] Cd Length: 372 Bit Score: 522.33 E-value: 2.06e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 1 MNELKRVSLYNIHKELGAKLVEFAGWEMPLEY-EGINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTL 79
Cdd:COG0404 1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYpGGVIAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 80 KINDIIYTPMCYENGGVVDDLLIYKFGEEDYLLVINAGNIDKDVAWIIKQSE-GYNVDIKNISSEVSQLAIQGPKAEEIL 158
Cdd:COG0404 81 KPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPpDFDVTITDVTDDWALLAVQGPKAREVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 159 QKITDIDLNSIKFYKSIPSTkVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGE-DICPAGLGCRDTLRFEA 237
Cdd:COG0404 161 AKLTDADLSALPFMSFREGT-VAGVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEfGVKPCGLGARDTLRLEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 238 ALPLYGHEINEHISPIEGGLSIFVKTNKESFIGKSILSKEKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKTVGFVTTGC 317
Cdd:COG0404 240 GYPLYGHELDETTTPLEAGLGWAVKLDKGDFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGT 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 531106561 318 ASPTTGKILGMGIIDSEYAKVGNEIGIAIRKKVVPAVIVKKPFYKKQYKK 367
Cdd:COG0404 320 FSPTLGKSIALAYVPAGLARPGTELEVEIRGKRVPAEVVKPPFYDPEGER 369
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
425-821 |
5.42e-171 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 499.45 E-value: 5.42e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 425 ELEVSKIVKRLSEENLSLEDLTCFLGAGAYDHYIPSIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGME 504
Cdd:cd00613 1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILENEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 505 IANASMYDGATAAIEACIMAMNQTR--KSKIVVSKTIHPETLSVLRTYLQYKDCEIVEIDfCNEYGTTDIEKLKASVDKD 582
Cdd:cd00613 81 VANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVP-SDEGGTVDLEALKEEVSEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 583 TACVLIQTPNFFGI-IEEMEEIEKITHENKAMLIMSVDPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASK 661
Cdd:cd00613 160 VAALMVQYPNTLGVfEDLIKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 662 SKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQHVRREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHY 741
Cdd:cd00613 240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 742 TYNKLVQTGKYKPiFKGKFFKEFAVQGNLNIETINDKLLEENILGGYNLEYNYPELKNSTLLCVTEKRSKEEIDKLVGIM 821
Cdd:cd00613 320 LAKRLKEVGGVLP-FNGPFFHEFVLRLPPLYGIRAEDLAKALIDGGFHAPTMYLPVDGTLMIEPTETETKEELDALLEAL 398
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
379-820 |
1.26e-159 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 471.47 E-value: 1.26e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 379 SYIPATSEDKSKMLKVVGLNSVDELF-SDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENlslEDLTCFLGAGAYDHY 457
Cdd:pfam02347 2 RHIGPSEKDQQEMLATLGYSSLDDLIgKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKN---TVYRSFIGMGYYDTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 458 IPSIIKH-ITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANASMYDGATAAIEACIMAMNQTRK--SKIV 534
Cdd:pfam02347 79 LPPVILRnILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKkgKKFV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 535 VSKTIHPETLSVLRTYLQYKDCEIVEIDFCNEygttdieklKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAML 614
Cdd:pfam02347 159 VDKDVHPQTLEVLKTRAKPFGIEIVEVDYTEE---------GVTDLKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 615 IMSVDPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQ 694
Cdd:pfam02347 230 VVAADLLALTLLKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 695 HVRREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHYTYNKLVQTGKykpIFKGKFFKEFavqgnLNIET 774
Cdd:pfam02347 310 HIRRDKATSNICTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGH---ELVHKHFFDT-----LLIEV 381
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 531106561 775 IN---DKLLEENILGGYNLEynYPELkNSTLLCVTEKRSKEEIDKLVGI 820
Cdd:pfam02347 382 EDkavEEVLARAEARGINLR--YVDL-GHVGIALDETVTKEDIDDLLQV 427
|
|
| gcvT |
TIGR00528 |
glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known ... |
4-362 |
2.66e-131 |
|
glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known as aminomethyltransferase (EC 2.1.2.10). It works with the H protein (GcvH), the P protein (GcvP), and lipoamide dehydrogenase. The reported sequence of the member from Aquifex aeolicus starts about 50 residues downstream of the start of other members of the family (perhaps in error); it scores below the trusted cutoff. Eukaryotic forms are mitochondrial and have an N-terminal transit peptide. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273121 [Multi-domain] Cd Length: 362 Bit Score: 396.12 E-value: 2.66e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 4 LKRVSLYNIHKELGAKLVEFAGWEMPLEYEGINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKIND 83
Cdd:TIGR00528 1 LKRTPLYDLHTELGGKMVDFGGWEMPVQYKGQIEEHNAVRTNAGLFDVSHMGQVKLSGPHSLKFLQRLTPNDVNALTPGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 84 IIYTPMCYENGGVVDDLLIYKFGEED-YLLVINAGNIDKDVAWIIKQSEGYnVDIKNISSEVSQLAIQGPKAEEILQKIT 162
Cdd:TIGR00528 81 AQYSVLLNPQGGVVDDLIIYKEGEDNrFYLVVNAATAEKDLEWFHEHLQNG-STLDCQSDIISLLALQGPKAKTILEPLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 163 DIDLNSIKFYKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGedICPAGLGCRDTLRFEAALPLY 242
Cdd:TIGR00528 160 DQTVPGLKPFFFGQEAEFALKKAFIARTGYTGEDGFEISIANEKAVEFWEQLLAAPG--VKPCGLGARDTLRLEAGMCLY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 243 GHEINEHISPIEGGLSIFV--KTNKESFIGKSILSKEKESGAKRKLVGFEMQGKGMPRNGYDIRI--GDKTVGFVTTGCA 318
Cdd:TIGR00528 238 GQELDESITPLEAGLGWVIskSRQKYDFIGRAVLMEQKENGTEKKLVGLEMLEKGIARNGYPIFLpnGETEVGIVTSGTA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 531106561 319 SPTTGKILGMGIIDSEYAKVGNEIGIAIRKKVVPAVIVKKPFYK 362
Cdd:TIGR00528 318 SPTLGKNIGLAYVPKEYHKIGTKLLVQVRNKFYPIKVVKMPFVR 361
|
|
| GCV_T |
pfam01571 |
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ... |
10-257 |
4.20e-114 |
|
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.
Pssm-ID: 460255 Cd Length: 254 Bit Score: 347.27 E-value: 4.20e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 10 YNIHKELGAKLVEFAGWEMPLEYE--GINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKINDIIYT 87
Cdd:pfam01571 1 YDRHVALGAKFVEFAGWEMPVQYGsnGILAEHRAVREAAGLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKLKPGRATYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 88 PMCYENGGVVDDLLIYKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQKITDIDLN 167
Cdd:pfam01571 81 LMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 168 S-IKFYKSIPsTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGE-DICPAGLGCRDTLRFEAALPLYGHE 245
Cdd:pfam01571 161 EaLPFFSFRE-IEIGGVPVRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAElGLRPAGLGARDSLRLEAGLPLYGHD 239
|
250
....*....|..
gi 531106561 246 INEHISPIEGGL 257
Cdd:pfam01571 240 LDEETTPLEAGL 251
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
377-824 |
0e+00 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 756.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 377 KFSYIPATSEDKSKMLKVVGLNSVDELFSDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENLSLEDLTCFLGAGAYDH 456
Cdd:PRK00451 1 GMPYIPHTEEDIREMLDAIGVKSIDELFADIPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEEYPSFLGAGAYDH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 457 YIPSIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANASMYDGATAAIEACIMAMNQTRKSKIVVS 536
Cdd:PRK00451 81 YIPAVVDHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMICELTGMDVANASMYDGATALAEAALMAVRITKRKKVLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 537 KTIHPETLSVLRTYLQYKDCEIVEIDFCNeyGTTDIEKLKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLIM 616
Cdd:PRK00451 161 GAVHPEYREVLKTYLKGQGIEVVEVPYED--GVTDLEALEAAVDDDTAAVVVQYPNFFGVIEDLEEIAEIAHAGGALFIV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 617 SVDPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQHV 696
Cdd:PRK00451 239 GVDPVSLGLLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 697 RREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHYTYNKLVQTGKYKPiFKGKFFKEFAVQGNLNIETIN 776
Cdd:PRK00451 319 RREKATSNICTNQALNALAAAIYMSLLGPEGLRELAEQNHQKAHYLAERLAEIGGVEL-FDGPFFNEFVVRLPKPAEEVN 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 531106561 777 DKLLEENILGGYNLEYNYPELKNSTLLCVTEKRSKEEIDKLVGIMEGL 824
Cdd:PRK00451 398 EALLEKGILGGYDLGRYYPELGNHLLVCVTEKRTKEDIDALVAALGEV 445
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
380-823 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 704.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 380 YIPATSEDKSKMLKVVGLNSVDELFSDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENlslEDLTCFLGAGAYDHYIP 459
Cdd:COG0403 7 YIPPTEEDRAEMLAAIGVDSLDELFDDIPAEIRLKRPLDLPEALSEAELLRHLRALAAKN---KVLTSFIGAGYYDHYVP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 460 SIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANASMYDGATAAIEACIMAMNQTRKS-KIVVSKT 538
Cdd:COG0403 84 AVVRNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTKRSnKVLVSED 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 539 IHPETLSVLRTYLQYKDCEIVEIDFCNeyGTTDIEKLKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLIMSV 618
Cdd:COG0403 164 VHPQTRAVLKTYAEPLGIEVVEVPDED--GVTDLEALKALLDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALVIVAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 619 DPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQHVRR 698
Cdd:COG0403 242 DPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQHIRR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 699 EKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHYTYNKLVQTGkYKPIFKGKFFKEFAVQGNLNIETINDK 778
Cdd:COG0403 322 EKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALG-VEVPFNGPFFDEFVVRLPKPAAEINAA 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 531106561 779 LLEENILGGYNLEYnypELKNSTLLCVTEKRSKEEIDKLVGIMEG 823
Cdd:COG0403 401 LLEKGILGGLNLRR---VDDDTLLVAVTETTTKEDIDALVEALAE 442
|
|
| gcvT |
PRK00389 |
glycine cleavage system aminomethyltransferase GcvT; |
3-366 |
0e+00 |
|
glycine cleavage system aminomethyltransferase GcvT;
Pssm-ID: 234742 [Multi-domain] Cd Length: 359 Bit Score: 545.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 3 ELKRVSLYNIHKELGAKLVEFAGWEMPLEYEGINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKIN 82
Cdd:PRK00389 1 MLKRTPLYDLHVALGAKMVDFGGWEMPVQYGSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKLKPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 83 DIIYTPMCYENGGVVDDLLIYKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQKIT 162
Cdd:PRK00389 81 KAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVVNAANREKDLAWIKSHAAGFGVEVTDRSDDLAMIAVQGPKAREKLQKLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 163 DIDLNSIKFYKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGEdicPAGLGCRDTLRFEAALPLY 242
Cdd:PRK00389 161 DADLSELKPFFGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEAGVK---PCGLGARDTLRLEAGMPLY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 243 GHEINEHISPIEGGLSIFVKTNKES-FIGKSILSKEKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKTVGFVTTGCASPT 321
Cdd:PRK00389 238 GQDMDETITPLEAGLGWTVKLEEKRdFIGREALEAQKEAGVERKLVGLELEERGIPRHGYPVLADGEEIGEVTSGTFSPT 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 531106561 322 TGKILGMGIIDSEYakvGNEIGIAIRKKVVPAVIVKKPFYKKQYK 366
Cdd:PRK00389 318 LGKSIALAYVPAGV---GDEVEVEIRGKQVPAKVVKPPFVRRGKR 359
|
|
| GcvT |
COG0404 |
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ... |
1-367 |
2.06e-180 |
|
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440173 [Multi-domain] Cd Length: 372 Bit Score: 522.33 E-value: 2.06e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 1 MNELKRVSLYNIHKELGAKLVEFAGWEMPLEY-EGINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTL 79
Cdd:COG0404 1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYpGGVIAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 80 KINDIIYTPMCYENGGVVDDLLIYKFGEEDYLLVINAGNIDKDVAWIIKQSE-GYNVDIKNISSEVSQLAIQGPKAEEIL 158
Cdd:COG0404 81 KPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPpDFDVTITDVTDDWALLAVQGPKAREVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 159 QKITDIDLNSIKFYKSIPSTkVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGE-DICPAGLGCRDTLRFEA 237
Cdd:COG0404 161 AKLTDADLSALPFMSFREGT-VAGVPVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEEfGVKPCGLGARDTLRLEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 238 ALPLYGHEINEHISPIEGGLSIFVKTNKESFIGKSILSKEKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKTVGFVTTGC 317
Cdd:COG0404 240 GYPLYGHELDETTTPLEAGLGWAVKLDKGDFIGKEALLRQKEEGPRRKLVGLELDGRGVPRAGAPVLADGEVVGEVTSGT 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 531106561 318 ASPTTGKILGMGIIDSEYAKVGNEIGIAIRKKVVPAVIVKKPFYKKQYKK 367
Cdd:COG0404 320 FSPTLGKSIALAYVPAGLARPGTELEVEIRGKRVPAEVVKPPFYDPEGER 369
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
425-821 |
5.42e-171 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 499.45 E-value: 5.42e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 425 ELEVSKIVKRLSEENLSLEDLTCFLGAGAYDHYIPSIIKHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGME 504
Cdd:cd00613 1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILENEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 505 IANASMYDGATAAIEACIMAMNQTR--KSKIVVSKTIHPETLSVLRTYLQYKDCEIVEIDfCNEYGTTDIEKLKASVDKD 582
Cdd:cd00613 81 VANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVP-SDEGGTVDLEALKEEVSEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 583 TACVLIQTPNFFGI-IEEMEEIEKITHENKAMLIMSVDPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASK 661
Cdd:cd00613 160 VAALMVQYPNTLGVfEDLIKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 662 SKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQHVRREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHY 741
Cdd:cd00613 240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 742 TYNKLVQTGKYKPiFKGKFFKEFAVQGNLNIETINDKLLEENILGGYNLEYNYPELKNSTLLCVTEKRSKEEIDKLVGIM 821
Cdd:cd00613 320 LAKRLKEVGGVLP-FNGPFFHEFVLRLPPLYGIRAEDLAKALIDGGFHAPTMYLPVDGTLMIEPTETETKEELDALLEAL 398
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
379-820 |
1.26e-159 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 471.47 E-value: 1.26e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 379 SYIPATSEDKSKMLKVVGLNSVDELF-SDIPEEVKLKRDLNLEIGKSELEVSKIVKRLSEENlslEDLTCFLGAGAYDHY 457
Cdd:pfam02347 2 RHIGPSEKDQQEMLATLGYSSLDDLIgKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKN---TVYRSFIGMGYYDTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 458 IPSIIKH-ITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANASMYDGATAAIEACIMAMNQTRK--SKIV 534
Cdd:pfam02347 79 LPPVILRnILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKkgKKFV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 535 VSKTIHPETLSVLRTYLQYKDCEIVEIDFCNEygttdieklKASVDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAML 614
Cdd:pfam02347 159 VDKDVHPQTLEVLKTRAKPFGIEIVEVDYTEE---------GVTDLKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 615 IMSVDPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQ 694
Cdd:pfam02347 230 VVAADLLALTLLKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 695 HVRREKATSNICSNQALNALVASIYMATMGKEGFKEVGMQSMKKAHYTYNKLVQTGKykpIFKGKFFKEFavqgnLNIET 774
Cdd:pfam02347 310 HIRRDKATSNICTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGH---ELVHKHFFDT-----LLIEV 381
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 531106561 775 IN---DKLLEENILGGYNLEynYPELkNSTLLCVTEKRSKEEIDKLVGI 820
Cdd:pfam02347 382 EDkavEEVLARAEARGINLR--YVDL-GHVGIALDETVTKEDIDDLLQV 427
|
|
| gcvT |
TIGR00528 |
glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known ... |
4-362 |
2.66e-131 |
|
glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known as aminomethyltransferase (EC 2.1.2.10). It works with the H protein (GcvH), the P protein (GcvP), and lipoamide dehydrogenase. The reported sequence of the member from Aquifex aeolicus starts about 50 residues downstream of the start of other members of the family (perhaps in error); it scores below the trusted cutoff. Eukaryotic forms are mitochondrial and have an N-terminal transit peptide. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273121 [Multi-domain] Cd Length: 362 Bit Score: 396.12 E-value: 2.66e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 4 LKRVSLYNIHKELGAKLVEFAGWEMPLEYEGINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKIND 83
Cdd:TIGR00528 1 LKRTPLYDLHTELGGKMVDFGGWEMPVQYKGQIEEHNAVRTNAGLFDVSHMGQVKLSGPHSLKFLQRLTPNDVNALTPGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 84 IIYTPMCYENGGVVDDLLIYKFGEED-YLLVINAGNIDKDVAWIIKQSEGYnVDIKNISSEVSQLAIQGPKAEEILQKIT 162
Cdd:TIGR00528 81 AQYSVLLNPQGGVVDDLIIYKEGEDNrFYLVVNAATAEKDLEWFHEHLQNG-STLDCQSDIISLLALQGPKAKTILEPLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 163 DIDLNSIKFYKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGedICPAGLGCRDTLRFEAALPLY 242
Cdd:TIGR00528 160 DQTVPGLKPFFFGQEAEFALKKAFIARTGYTGEDGFEISIANEKAVEFWEQLLAAPG--VKPCGLGARDTLRLEAGMCLY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 243 GHEINEHISPIEGGLSIFV--KTNKESFIGKSILSKEKESGAKRKLVGFEMQGKGMPRNGYDIRI--GDKTVGFVTTGCA 318
Cdd:TIGR00528 238 GQELDESITPLEAGLGWVIskSRQKYDFIGRAVLMEQKENGTEKKLVGLEMLEKGIARNGYPIFLpnGETEVGIVTSGTA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 531106561 319 SPTTGKILGMGIIDSEYAKVGNEIGIAIRKKVVPAVIVKKPFYK 362
Cdd:TIGR00528 318 SPTLGKNIGLAYVPKEYHKIGTKLLVQVRNKFYPIKVVKMPFVR 361
|
|
| GCV_T |
pfam01571 |
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ... |
10-257 |
4.20e-114 |
|
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.
Pssm-ID: 460255 Cd Length: 254 Bit Score: 347.27 E-value: 4.20e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 10 YNIHKELGAKLVEFAGWEMPLEYE--GINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKINDIIYT 87
Cdd:pfam01571 1 YDRHVALGAKFVEFAGWEMPVQYGsnGILAEHRAVREAAGLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKLKPGRATYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 88 PMCYENGGVVDDLLIYKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQKITDIDLN 167
Cdd:pfam01571 81 LMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKLDVVVVDVTDDYALLALQGPKAREVLEKLTDGDLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 168 S-IKFYKSIPsTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGE-DICPAGLGCRDTLRFEAALPLYGHE 245
Cdd:pfam01571 161 EaLPFFSFRE-IEIGGVPVRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAElGLRPAGLGARDSLRLEAGLPLYGHD 239
|
250
....*....|..
gi 531106561 246 INEHISPIEGGL 257
Cdd:pfam01571 240 LDEETTPLEAGL 251
|
|
| PLN02319 |
PLN02319 |
aminomethyltransferase |
3-367 |
4.02e-94 |
|
aminomethyltransferase
Pssm-ID: 177953 [Multi-domain] Cd Length: 404 Bit Score: 300.49 E-value: 4.02e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 3 ELKRVSLYNIHKELGAKLVEFAGWEMPLEYEG-INKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKI 81
Cdd:PLN02319 31 NLKKTALYDFHVANGGKMVPFAGWSMPIQYKDsIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAIPFLETLVVADIAGLKD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 82 NDIIYTPMCYENGGVVDDLLIYKFGEEDYLLVINAGNIDKDVAWIIKQSEGYNVDIKNIS----SEVSQLAIQGPKAEEI 157
Cdd:PLN02319 111 GTGTLSVFTNEKGGIIDDTVITKVTDDHIYLVVNAGCRDKDLAHIEEHMKAFKAKGGDVSwhvhDERSLLALQGPLAAPV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 158 LQKITDIDLNSIKFyKSIPSTKVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLKVGGEDICPAGLGCRDTLRFEA 237
Cdd:PLN02319 191 LQHLTKEDLSKMYF-GDFRITDINGADCFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSEGKVRLTGLGARDSLRLEA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 238 ALPLYGHEINEHISPIEGGLSIFV-KTNKE--SFIGKSILSKEKESGAKRKLVGFemQGKGMP-RNGYDIRIGD-KTVGF 312
Cdd:PLN02319 270 GLCLYGNDLEEHITPVEAGLAWTIgKRRRAegGFLGADVILKQLKEGVSRRRVGF--ISSGAPaRSHSEILDESgEKIGE 347
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 531106561 313 VTTGCASPTTGKILGMGIIDSEYAKVGNEIGIAIRKKVVPAVIVKKPFYKKQYKK 367
Cdd:PLN02319 348 VTSGGFSPCLKKNIAMGYVKSGFHKAGTEVKVEVRGKMYDAVVTKMPFVPTKYYK 402
|
|
| gcvT |
PRK13579 |
glycine cleavage system aminomethyltransferase GcvT; |
4-367 |
1.07e-87 |
|
glycine cleavage system aminomethyltransferase GcvT;
Pssm-ID: 237435 [Multi-domain] Cd Length: 370 Bit Score: 282.61 E-value: 1.07e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 4 LKRVSLYNIHKELGAKLVEFAGWEMPLEYE-GINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKIN 82
Cdd:PRK13579 9 LKTLPLHALHLAAGARMVPFAGYDMPVQYPaGVLKEHLHTRAHAGLFDVSHMGQIEVSGKDAAAALERLVPVDILALKEG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 83 DIIYTPMCYENGGVVDDLLIYKFGeEDYLLVINAGNIDKDVAWIIKQSEGyNVDIkNISSEVSQLAIQGPKAEEILQKIt 162
Cdd:PRK13579 89 RQRYTFFTNEQGGILDDLMVTNLG-DHLFLVVNAACKDADIAHLREHLSD-ECEV-NPLDDRALLALQGPEAEAVLADL- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 163 DIDLNSIKFYKSIPSTkVCGCPCLVSRTGYTGEDGFEIYCKNKYVEIIWNEVLkvGGEDICPAGLGCRDTLRFEAALPLY 242
Cdd:PRK13579 165 GPPVAALRFMDGFEPR-LHGVDCFVSRSGYTGEDGFEISVPADAAEALAEALL--ADPRVEPIGLGARDSLRLEAGLCLY 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 243 GHEINEHISPIEGGLSIFV-KTNKES--FIGKSILSKEKESGAKRKLVGFEMQGKGMPRNGYDIRIGDKT-VGFVTTGCA 318
Cdd:PRK13579 242 GHDIDTTTTPVEAALEWAIqKARREAggFPGAKAILAALAKGASRRRVGLKPEGRAPVREGAPLFDDAGTeIGTVTSGGF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 531106561 319 SPTTGKILGMGIIDSEYAKVGNEIGIAIRKKVVPAVIVKKPFYKKQYKK 367
Cdd:PRK13579 322 GPSVGGPVAMGYVPASLAAPGTAVFAEVRGKRLPVTVHALPFVPHRYKR 370
|
|
| PLN02414 |
PLN02414 |
glycine dehydrogenase (decarboxylating) |
383-731 |
6.58e-86 |
|
glycine dehydrogenase (decarboxylating)
Pssm-ID: 178035 [Multi-domain] Cd Length: 993 Bit Score: 294.36 E-value: 6.58e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 383 ATSEDKSKMLKVVGLNSVDELF-SDIPEEVKlKRDLNLEI---GKSELEVSKIVKRLSEENLSLEDltcFLGAGAYDHYI 458
Cdd:PLN02414 42 ATPEEQKAMAEYCGFDSLDALIdATVPKSIR-LDSMKLSKydeGLTESQMLEHMKSLASKNKVFKS---YIGMGYYNTHV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 459 PSII-KHITSRSEFYTAYTPYQAEISQGTLQVVFEFQSMIAEITGMEIANASMYDGATAAIEACIM--AMNQTRKSKIVV 535
Cdd:PLN02414 118 PPVIlRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNASLLDEGTAAAEAMAMcnNILKGKKKKFLI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 536 SKTIHPETLSVLRTYLQYKDCEIVeidfcneygTTDIEKLKASvDKDTACVLIQTPNFFGIIEEMEEIEKITHENKAMLI 615
Cdd:PLN02414 198 ASNCHPQTIDVCQTRADGLGLEVV---------VADEKDFDYS-SGDVCGVLVQYPATDGEVLDYAEFVKNAHANGVKVV 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 616 MSVDPISLGVLKTPGEIGADIVVGEAQSLGNPLNFGGPYVGFLASKSKYTRKMPGRIVGQSLDVEGKIAYVLTLQTREQH 695
Cdd:PLN02414 268 MATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSVDSSGKPALRMAMQTREQH 347
|
330 340 350
....*....|....*....|....*....|....*.
gi 531106561 696 VRREKATSNICSNQALNALVASIYMATMGKEGFKEV 731
Cdd:PLN02414 348 IRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTI 383
|
|
| dmdA |
PRK12486 |
dimethylsulfoniopropionate demethylase; |
28-360 |
2.63e-38 |
|
dimethylsulfoniopropionate demethylase;
Pssm-ID: 237113 [Multi-domain] Cd Length: 368 Bit Score: 146.82 E-value: 2.63e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 28 MPLEYEGINKEHEKVRKSAGIFDVSHMGEVQIKGAESEKFIQNLVTNDISTLKINDIIYTPMCYENGGVVDDLLIYKFGE 107
Cdd:PRK12486 36 LPTVFESVEDDYAHLKEHVQVWDVAVERQVEIRGPDAARLVQMLTPRDLRGMKPGQCYYVPIVDETGGMLNDPVALKLAE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 108 EDYLLVINAGNIdkdVAWIIKQSEGYNVDIKNISSEVSQLAIQGPKAEEILQKITDIDLNSIKFYKsIPSTKVCGCPCLV 187
Cdd:PRK12486 116 DRWWISIADSDL---LLWVKGLANGRKLDVLVVEPDVSPLAVQGPKADALMARVFGEAIRDLRFFR-FGYFDFEGTDLVI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 188 SRTGYTGEDGFEIYCKNKYVEI-IWNEVLKVGGE-DICPaglGCRDTL-RFEAALPLYGHEINEHISPIEGGLSIFVKTN 264
Cdd:PRK12486 192 ARSGYSKQGGFEIYVEGSDLGMpLWDALFEAGKDlNVRA---GCPNLIeRIEGGLLSYGNDMTRDNTPHECGLGRFCNTQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 265 KE-SFIGKSILSKEKESGAKRKLVGFEMQGKGMPRNG--YDIRIGDKTVGFVTTGCASPTTGKILGMGIIDSEYAKVGNE 341
Cdd:PRK12486 269 TDiGCIGKDALLRVAKEGPQKQIRGIKIGGERIPPCDraWPLLAGDNRVGQVTSAAYSPDFQTNVAIGMVRMTHWDPGTG 348
|
330
....*....|....*....
gi 531106561 342 IGIAIRKKVVPAVIVKKPF 360
Cdd:PRK12486 349 LEVETPDGMRPATVREGFW 367
|
|
| GCV_T_C |
pfam08669 |
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ... |
284-362 |
6.64e-27 |
|
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.
Pssm-ID: 462554 [Multi-domain] Cd Length: 80 Bit Score: 104.48 E-value: 6.64e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 284 RKLVGFEMQ-GKGMPRNGYDIRIGDKTVGFVTTGCASPTTGKILGMGIIDSEYAKVGNEIGIAIRKKVVPAVIVKKPFYK 362
Cdd:pfam08669 1 RRLVGLELDdGDPLLRGGEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVDAELAKPGTEVEVEIRGKRVPATVVKLPFYD 80
|
|
| PRK04366 |
PRK04366 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPB; |
401-592 |
1.38e-14 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
Pssm-ID: 235292 Cd Length: 481 Bit Score: 77.07 E-value: 1.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 401 DELFSDIPEEVKLKRDLNL-EIgkSELEVSKIVKRLSEENLSLeDL------TCFLgagaydHYIPSIIKHITSRSEFyT 473
Cdd:PRK04366 28 EVLESLLPEELLRKEPPELpEV--SELEVVRHYTRLSQKNYGV-DTgfyplgSCTM------KYNPKINEKVARLPGF-A 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 474 AYTPYQ-AEISQGTLQVVFEFQSMIAEITGMeiANASMYDGATAAIEACIMAM--------NQTRKSKIVVSKTIH---P 541
Cdd:PRK04366 98 ELHPLQpEETVQGALELMYELQEWLKEITGM--DAVTLQPAAGAHGELTGLLMirayhearGDTKRTEVIVPDSAHgtnP 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 531106561 542 ETLSVlrtylqyKDCEIVEIDfCNEYGTTDIEKLKASVDKDTACVLIQTPN 592
Cdd:PRK04366 176 ASAAM-------AGFKVVEIP-SNEDGLVDLEALKAAVGEDTAALMLTNPN 218
|
|
| GcvP2 |
COG1003 |
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ... |
401-592 |
1.80e-09 |
|
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440627 Cd Length: 468 Bit Score: 60.82 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 401 DELFSDIPEEVKLKRDLNL-EIgkSELEVSKIVKRLSEENLSLedltcflgagayDH-----------YIPSIIKHITSR 468
Cdd:COG1003 8 ADAASLLPEALLRKSPVFLpEV--SETEVLRHYTRLSQKNLGL------------DTgmiplgsctmkYNPKINEEPATL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531106561 469 SEFyTAYTPYQ-AEISQGTLQVVFEFQSMIAEITGM-------------EIANASMydgataaIEACIMAMNQTRKSKIV 534
Cdd:COG1003 74 PGF-ANLHPFQpEETVQGYLELMYELEEWLAEITGMdavslqpnagaqgEYAGLLA-------IRAYHESRGEGHRNEIL 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 531106561 535 VSKTIH---PETLSVlrtylqyKDCEIVEIDfCNEYGTTDIEKLKASVDKDTACVLIQTPN 592
Cdd:COG1003 146 IPDSAHgtnPASAAM-------AGFKVVVVK-SDEDGNVDLEDLKAKVGDRTAALMLTNPS 198
|
|
| |
