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Conserved domains on  [gi|530788259|ref|NP_001269032|]
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transmembrane O-methyltransferase [Falco peregrinus]

Protein Classification

O-methyltransferase( domain architecture ID 11467877)

O-methyltransferase of the class I-like SAM-binding methyltransferase superfamily, such as catechol O-methyltransferases that can use various catechol-like compounds

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.-.-
Gene Ontology:  GO:0008757|GO:0032259|GO:1904047|GO:0008168|GO:0008171
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 85-217 2.27e-34

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443298  Cd Length: 173  Bit Score: 121.83  E-value: 2.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259  85 PIKGRIVERLLYERAPLRVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEQtVELIVGPSEEV 164
Cdd:COG4122    2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADR-IRLILGDALEV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530788259 165 IPRLREKhgllKANFVFMDHWKRCYLRDLQLLEthQLLAEGATILADNVLFPG 217
Cdd:COG4122   81 LPRLADG----PFDLVFIDADKSNYPDYLELAL--PLLRPGGLIVADNVLWHG 127
 
Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 85-217 2.27e-34

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 121.83  E-value: 2.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259  85 PIKGRIVERLLYERAPLRVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEQtVELIVGPSEEV 164
Cdd:COG4122    2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADR-IRLILGDALEV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530788259 165 IPRLREKhgllKANFVFMDHWKRCYLRDLQLLEthQLLAEGATILADNVLFPG 217
Cdd:COG4122   81 LPRLADG----PFDLVFIDADKSNYPDYLELAL--PLLRPGGLIVADNVLWHG 127
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 83-217 3.46e-17

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 77.54  E-value: 3.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259   83 VGPIKGRIVERLLYERAPLRVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEQtVELIVGPSE 162
Cdd:pfam01596  27 VSPDEGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPEDGKITAIDIDPEAYEIAKKFIQKAGVAHK-ISFILGPAL 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530788259  163 EVIPRLREKHGLLKANFVFMDHWKRCYLRDLQ-LLEthqLLAEGATILADNVLFPG 217
Cdd:pfam01596 106 KVLEQLTQDKPLPEFDFIFIDADKSNYPNYYErLLE---LLKVGGLMAIDNTLWHG 158
PLN02476 PLN02476
O-methyltransferase
 83-217 1.21e-08

O-methyltransferase


Pssm-ID: 178094  Cd Length: 278  Bit Score: 54.30  E-value: 1.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259  83 VGPIKGRIVERLLYERAPLRVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEQtVELIVGPSE 162
Cdd:PLN02476 102 VSPDQAQLLAMLVQILGAERCIEVGVYTGYSSLAVALVLPESGCLVACERDSNSLEVAKRYYELAGVSHK-VNVKHGLAA 180

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530788259 163 EVIPRLREKHGLLKANFVFMDHWKRCYLRDLQLLetHQLLAEGATILADNVLFPG 217
Cdd:PLN02476 181 ESLKSMIQNGEGSSYDFAFVDADKRMYQDYFELL--LQLVRVGGVIVMDNVLWHG 233
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 102-209 1.78e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.50  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259 102 RVLELGTYCGYGTVLLAQGlpPGARLYTVELDPRHAAVAEKVIRLAGFDEqtVELIVGPSEEVIPRLREKHgllkaNFVF 181
Cdd:cd02440    1 RVLDLGCGTGALALALASG--PGARVTGVDISPVALELARKAAAALLADN--VEVLKGDAEELPPEADESF-----DVII 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 530788259 182 MDHWKRCYLRDLQ--LLETHQLLAEGATIL 209
Cdd:cd02440   72 SDPPLHHLVEDLArfLEEARRLLKPGGVLV 101
 
Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 85-217 2.27e-34

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 121.83  E-value: 2.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259  85 PIKGRIVERLLYERAPLRVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEQtVELIVGPSEEV 164
Cdd:COG4122    2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADR-IRLILGDALEV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530788259 165 IPRLREKhgllKANFVFMDHWKRCYLRDLQLLEthQLLAEGATILADNVLFPG 217
Cdd:COG4122   81 LPRLADG----PFDLVFIDADKSNYPDYLELAL--PLLRPGGLIVADNVLWHG 127
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 83-217 3.46e-17

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 77.54  E-value: 3.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259   83 VGPIKGRIVERLLYERAPLRVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEQtVELIVGPSE 162
Cdd:pfam01596  27 VSPDEGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPEDGKITAIDIDPEAYEIAKKFIQKAGVAHK-ISFILGPAL 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530788259  163 EVIPRLREKHGLLKANFVFMDHWKRCYLRDLQ-LLEthqLLAEGATILADNVLFPG 217
Cdd:pfam01596 106 KVLEQLTQDKPLPEFDFIFIDADKSNYPNYYErLLE---LLKVGGLMAIDNTLWHG 158
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 104-213 7.11e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 65.79  E-value: 7.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259  104 LELGTYCGYGTVLLAQGLPPGA--RLYTVELDPrHAAVAEKVIRLAGFDEQtVELIVGPSEEVIPRLREKhgllKANFVF 181
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALRDNGlgRLTAVDPDP-GAEEAGALLRKAGLDDR-VRLIVGDSREALPSLADG----PIDLLF 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 530788259  182 MD--HWKRCYLRDLQLLETHqlLAEGATILADNV 213
Cdd:pfam13578  75 IDgdHTYEAVLNDLELWLPR--LAPGGVILFHDI 106
PLN02476 PLN02476
O-methyltransferase
 83-217 1.21e-08

O-methyltransferase


Pssm-ID: 178094  Cd Length: 278  Bit Score: 54.30  E-value: 1.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259  83 VGPIKGRIVERLLYERAPLRVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEQtVELIVGPSE 162
Cdd:PLN02476 102 VSPDQAQLLAMLVQILGAERCIEVGVYTGYSSLAVALVLPESGCLVACERDSNSLEVAKRYYELAGVSHK-VNVKHGLAA 180

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530788259 163 EVIPRLREKHGLLKANFVFMDHWKRCYLRDLQLLetHQLLAEGATILADNVLFPG 217
Cdd:PLN02476 181 ESLKSMIQNGEGSSYDFAFVDADKRMYQDYFELL--LQLVRVGGVIVMDNVLWHG 233
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 102-209 1.78e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.50  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259 102 RVLELGTYCGYGTVLLAQGlpPGARLYTVELDPRHAAVAEKVIRLAGFDEqtVELIVGPSEEVIPRLREKHgllkaNFVF 181
Cdd:cd02440    1 RVLDLGCGTGALALALASG--PGARVTGVDISPVALELARKAAAALLADN--VEVLKGDAEELPPEADESF-----DVII 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 530788259 182 MDHWKRCYLRDLQ--LLETHQLLAEGATIL 209
Cdd:cd02440   72 SDPPLHHLVEDLArfLEEARRLLKPGGVLV 101
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 102-160 3.00e-06

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 46.62  E-value: 3.00e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530788259 102 RVLELGTYCGYGTVLLAQgLppGARLYTVELDPRHAAVAEKVIRLAGFDeqTVELIVGP 160
Cdd:COG2518   69 RVLEIGTGSGYQAAVLAR-L--AGRVYSVERDPELAERARERLAALGYD--NVTVRVGD 122
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 102-166 2.56e-05

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 44.38  E-value: 2.56e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530788259 102 RVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEqTVELIVGPSEEVIP 166
Cdd:COG2519   94 RVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPD-NVELKLGDIREGID 157
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
102-191 5.05e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 43.49  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259 102 RVLELGTycgyGTVLLAQ-GLPPGAR-LYTVELDPRHAAVAEKVIRLAGFDEQtVELIVGPSEEVipRLREK-------- 171
Cdd:COG4076   38 VVLDIGT----GSGLLSMlAARAGAKkVYAVEVNPDIAAVARRIIAANGLSDR-ITVINADATDL--DLPEKadviisem 110

                         90       100
                 ....*....|....*....|...
gi 530788259 172 --HGLLKANFV-FMDHWKRCYLR 191
Cdd:COG4076  111 ldTALLDEGQVpILNHARKRLLK 133
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 102-159 7.76e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 39.61  E-value: 7.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530788259 102 RVLELGTYCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDeqTVELIVG 159
Cdd:PRK13942  79 KVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKKLGYD--NVEVIVG 134
PLN02589 PLN02589
caffeoyl-CoA O-methyltransferase
 51-218 8.33e-04

caffeoyl-CoA O-methyltransferase


Pssm-ID: 166230  Cd Length: 247  Bit Score: 39.98  E-value: 8.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259  51 FQYLLAHAI-PGDPRHILQTFDQWCYCCEHLSSVGPIKGRIVERLLYERAPLRVLELGTYCGYGTVLLAQGLPPGARLYT 129
Cdd:PLN02589  30 YQYILETSVyPREPESMKELRELTAKHPWNIMTTSADEGQFLNMLLKLINAKNTMEIGVYTGYSLLATALALPEDGKILA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259 130 VELDPRHAAVAEKVIRLAGFDEQtVELIVGPSEEVIPRLREK---HGLLkaNFVFMDHWKRCYLRDLQLLEthQLLAEGA 206
Cdd:PLN02589 110 MDINRENYELGLPVIQKAGVAHK-IDFREGPALPVLDQMIEDgkyHGTF--DFIFVDADKDNYINYHKRLI--DLVKVGG 184

                        170
                 ....*....|..
gi 530788259 207 TILADNVLFPGA 218
Cdd:PLN02589 185 VIGYDNTLWNGS 196
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 98-212 1.54e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 38.74  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788259  98 RAPLRVLELGtyCGYGTVLLAQGLPPGARLYTVELDPRHAAVAEKVIRLAGFDEqtVELIVGPSEEVIPRLREkhgllKA 177
Cdd:COG0500   25 PKGGRVLDLG--CGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGN--VEFLVADLAELDPLPAE-----SF 95

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 530788259 178 NFVFMdhwkRCYLRDLQLLETHQLLAEGATILADN 212
Cdd:COG0500   96 DLVVA----FGVLHHLPPEEREALLRELARALKPG 126
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 98-152 7.90e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 36.66  E-value: 7.90e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530788259  98 RAPLRVLELGTYCGYGTVLLAQGLpPGARLYTVELDPRHAAVAEKVIRLAGFDEQ 152
Cdd:COG4123   36 KKGGRVLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELARRNVALNGLEDR 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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