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Conserved domains on  [gi|530537281|ref|NP_001268958|]
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leucine-rich repeat-containing protein 51 [Octodon degus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 705725)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 super family cl25994
Leucine-rich repeat;
84-173 6.43e-11

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 58.24  E-value: 6.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281   84 IDLSFNDLTSID-----PVLTTVF------------------NLSVLYLHGNSIQRLGEVNKLAVLPRLRSLTLHGNPIE 140
Cdd:pfam14580  47 IDFSDNEIRKLDgfpllRRLKTLLlnnnricrigeglgealpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT 126

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530537281  141 EEKGYRQYVLCSVPRITTFDFSGVTKSDRTTAE 173
Cdd:pfam14580 127 NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
84-173 6.43e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 58.24  E-value: 6.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281   84 IDLSFNDLTSID-----PVLTTVF------------------NLSVLYLHGNSIQRLGEVNKLAVLPRLRSLTLHGNPIE 140
Cdd:pfam14580  47 IDFSDNEIRKLDgfpllRRLKTLLlnnnricrigeglgealpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT 126

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530537281  141 EEKGYRQYVLCSVPRITTFDFSGVTKSDRTTAE 173
Cdd:pfam14580 127 NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.93e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 1.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281  52 QSLWLNNNVLSDLrdftqvvSQLLEHPENLAWIDLSFNDLTSIDPVLTTVFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  116 ESLDLSGNQLTDL-------PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                         90
                 ....*....|
gi 530537281 132 LTLHGNPIEE 141
Cdd:COG4886  187 LDLSNNQITD 196
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-178 1.15e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281  85 DLSFNDLTSIDPvLTTVFNLSVLYLHGNSIQRLGEVNK-LAVLPRLRSLTLHGNPIEEEKGYRQYVLCSVPRITTFDFSG 163
Cdd:cd21340  126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204

                         90
                 ....*....|....*
gi 530537281 164 VTKSDRTTAEVWKRM 178
Cdd:cd21340  205 ITDTERQFLKRLKAR 219
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
84-173 6.43e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 58.24  E-value: 6.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281   84 IDLSFNDLTSID-----PVLTTVF------------------NLSVLYLHGNSIQRLGEVNKLAVLPRLRSLTLHGNPIE 140
Cdd:pfam14580  47 IDFSDNEIRKLDgfpllRRLKTLLlnnnricrigeglgealpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT 126

                          90       100       110
                  ....*....|....*....|....*....|...
gi 530537281  141 EEKGYRQYVLCSVPRITTFDFSGVTKSDRTTAE 173
Cdd:pfam14580 127 NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.93e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 1.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281  52 QSLWLNNNVLSDLrdftqvvSQLLEHPENLAWIDLSFNDLTSIDPVLTTVFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  116 ESLDLSGNQLTDL-------PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                         90
                 ....*....|
gi 530537281 132 LTLHGNPIEE 141
Cdd:COG4886  187 LDLSNNQITD 196
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 4.15e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 4.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281  52 QSLWLNNNVLSDLrdftqvvSQLLEHPENLAWIDLSFNDLTSIDPVLTTVFNLSVLYLHGNSIQRLGEvnkLAVLPRLRS 131
Cdd:COG4886  185 KELDLSNNQITDL-------PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEE 254

                         90
                 ....*....|
gi 530537281 132 LTLHGNPIEE 141
Cdd:COG4886  255 LDLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 2.88e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 2.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281  52 QSLWLNNNVLSDLRDftqVVSQLlehpENLAWIDLSFNDLTSIDPVLTTVFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  139 KELDLSNNQLTDLPE---PLGNL----TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEE 209

                         90
                 ....*....|
gi 530537281 132 LTLHGNPIEE 141
Cdd:COG4886  210 LDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 3.68e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 3.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281  52 QSLWLNNNVLSDLRDFtqvVSQLlehpENLAWIDLSFNDLTSIDPVLTTVFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  162 KSLDLSNNQLTDLPEE---LGNL----TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLET 232

                         90
                 ....*....|
gi 530537281 132 LTLHGNPIEE 141
Cdd:COG4886  233 LDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 6.53e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 6.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281  52 QSLWLNNNVLSDLrdftqvvSQLLEHPENLAWIDLSFNDLTSIdPVLTTVFNLSVLYLHGNSIQRLGEvnkLAVLPRLRS 131
Cdd:COG4886  208 EELDLSGNQLTDL-------PEPLANLTNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPP---LANLTNLKT 276

                         90
                 ....*....|
gi 530537281 132 LTLHGNPIEE 141
Cdd:COG4886  277 LDLSNNQLTD 286
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-178 1.15e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530537281  85 DLSFNDLTSIDPvLTTVFNLSVLYLHGNSIQRLGEVNK-LAVLPRLRSLTLHGNPIEEEKGYRQYVLCSVPRITTFDFSG 163
Cdd:cd21340  126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204

                         90
                 ....*....|....*
gi 530537281 164 VTKSDRTTAEVWKRM 178
Cdd:cd21340  205 ITDTERQFLKRLKAR 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-141 1.97e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 1.97e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530537281  75 LEHPENLAWIDLSFNDLTSIDPVLTTVFNLSVLYLHGNSIQRLGEVnkLAVLPRLRSLTLHGNPIEE 141
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTD 173
LRR_8 pfam13855
Leucine rich repeat;
80-139 4.64e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 4.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530537281   80 NLAWIDLSFNDLTSIDP-VLTTVFNLSVLYLHGNSIQRLGEvNKLAVLPRLRSLTLHGNPI 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-141 9.83e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 9.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530537281  86 LSFND--LTSIDpVLTTVFNLSVLYLHGNSIQRLgevNKLAVLPRLRSLTLHGNPIEE 141
Cdd:cd21340    7 LYLNDknITKID-NLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNNQIEK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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