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Conserved domains on  [gi|530407707|ref|XP_005255213|]
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transcription factor E4F1 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
236-647 1.10e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 236 KLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCSKCGKSFRES 313
Cdd:COG5048   25 KSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 314 galTRHLKSLTPCT---------------EKIRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIETSPVIHLVT 378
Cdd:COG5048  105 ---ASSSSLSSSSSnsndnnllsshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 379 DAKGTVIHEVHVQM----QELSLGMKALAPEPPVSQELPCSSEGSREnllhqAMQNSGIVLERAAGEEGALEPAPAAGSS 454
Cdd:COG5048  182 SNLSLLISSNVSTSipssSENSPLSSSYSIPSSSSDQNLENSSSSLP-----LTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 455 PQPLAVAAPQLPVLEVQPLETVASEASAVPRT-HPCPQCSETFPTAATLEAHKRG--HTGP--RPFAC--AQCGKAFPKA 527
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 528 YLLKKHQEVHVRERRFRC--GDCGKLYK---------TIAHVRGHRRVHSDERPYpcPKCGKRYKTKNAQQVHFRTHLEE 596
Cdd:COG5048  337 DALKRHILLHTSISPAKEklLNSSSKFSpllnneppqSLQQYKDLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLSF 414

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530407707 597 KPHVCQF--CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 647
Cdd:COG5048  415 RPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
236-647 1.10e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 236 KLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCSKCGKSFRES 313
Cdd:COG5048   25 KSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 314 galTRHLKSLTPCT---------------EKIRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIETSPVIHLVT 378
Cdd:COG5048  105 ---ASSSSLSSSSSnsndnnllsshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 379 DAKGTVIHEVHVQM----QELSLGMKALAPEPPVSQELPCSSEGSREnllhqAMQNSGIVLERAAGEEGALEPAPAAGSS 454
Cdd:COG5048  182 SNLSLLISSNVSTSipssSENSPLSSSYSIPSSSSDQNLENSSSSLP-----LTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 455 PQPLAVAAPQLPVLEVQPLETVASEASAVPRT-HPCPQCSETFPTAATLEAHKRG--HTGP--RPFAC--AQCGKAFPKA 527
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 528 YLLKKHQEVHVRERRFRC--GDCGKLYK---------TIAHVRGHRRVHSDERPYpcPKCGKRYKTKNAQQVHFRTHLEE 596
Cdd:COG5048  337 DALKRHILLHTSISPAKEklLNSSSKFSpllnneppqSLQQYKDLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLSF 414

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530407707 597 KPHVCQF--CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 647
Cdd:COG5048  415 RPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
613-637 1.58e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.58e-05
                          10        20
                  ....*....|....*....|....*
gi 530407707  613 SLVRHVRHHTGEKPFKCYKCGRGFA 637
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
236-647 1.10e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 236 KLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHEC--KLCGASFRTKGSLIRHHRRHTDERPYKCSKCGKSFRES 313
Cdd:COG5048   25 KSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 314 galTRHLKSLTPCT---------------EKIRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIETSPVIHLVT 378
Cdd:COG5048  105 ---ASSSSLSSSSSnsndnnllsshslppSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 379 DAKGTVIHEVHVQM----QELSLGMKALAPEPPVSQELPCSSEGSREnllhqAMQNSGIVLERAAGEEGALEPAPAAGSS 454
Cdd:COG5048  182 SNLSLLISSNVSTSipssSENSPLSSSYSIPSSSSDQNLENSSSSLP-----LTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 455 PQPLAVAAPQLPVLEVQPLETVASEASAVPRT-HPCPQCSETFPTAATLEAHKRG--HTGP--RPFAC--AQCGKAFPKA 527
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 528 YLLKKHQEVHVRERRFRC--GDCGKLYK---------TIAHVRGHRRVHSDERPYpcPKCGKRYKTKNAQQVHFRTHLEE 596
Cdd:COG5048  337 DALKRHILLHTSISPAKEklLNSSSKFSpllnneppqSLQQYKDLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLSF 414

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530407707 597 KPHVCQF--CSRGFREKGSLVRHVRHHTGEKPFKCYKCGRgFAEHGTLNRHLR 647
Cdd:COG5048  415 RPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
613-637 1.58e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.58e-05
                          10        20
                  ....*....|....*....|....*
gi 530407707  613 SLVRHVRHHTGEKPFKCYKCGRGFA 637
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-310 6.05e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 6.05e-05
                          10        20
                  ....*....|....*....|....
gi 530407707  287 SLIRHHRRHTDERPYKCSKCGKSF 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 560-622 6.60e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 6.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 560 GHRRVHSDERPYPCP--KCGKRYKTKNAQQVHfRTH--------------------LEEKPHVCQFCSRGFREKGSLVRH 617
Cdd:COG5189  339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417


                 ....*
gi 530407707 618 VRHHT 622
Cdd:COG5189  418 RKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 511-593 2.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707 511 GPRPFACA--QCGKAFPKAYLLKKHQeVHvrerrfrcGDCGKLYKTIAHVRGHRRVHSDERPYPCPKCGKRYKTKNAQQV 588
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 530407707 589 HfRTH 593
Cdd:COG5189  417 H-RKH 420
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 273-295 4.00e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 4.00e-04
                          10        20
                  ....*....|....*....|...
gi 530407707  273 HECKLCGASFRTKGSLIRHHRRH 295
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 488-574 5.23e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 40.10  E-value: 5.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530407707  488 PC--PQCSETFPTAATLEAHKRGHTGP------RPFACA--QCGKAFPKAYLLKKHQEVHVRERR-FRCGDCGKLYKTIA 556
Cdd:pfam15909   1 PCssPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSalSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHR 80

                          90
                  ....*....|....*...
gi 530407707  557 HVRGHRRVHSDERPYPCP 574
Cdd:pfam15909  81 SLFKHLHVCAEHAQSPAP 98
zf-H2C2_2 pfam13465
Zinc-finger double domain;
502-524 5.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.34e-04
                          10        20
                  ....*....|....*....|...
gi 530407707  502 LEAHKRGHTGPRPFACAQCGKAF 524
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
557-582 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 530407707  557 HVRGHRRVHSDERPYPCPKCGKRYKT 582
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 301-322 3.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|..
gi 530407707  301 YKCSKCGKSFRESGALTRHLKS 322
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRT 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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