|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
12-775 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1221.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 12 LYVIKRNGRSELIHMDKITRKLQRLSYGLNKEFIDHAAITVRVVKMLYPGVTTEDLDMHAAAETASMAFVHDDYAILAGR 91
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 92 IMVDNLHKKVEGDLVSVTNRLYEH---------NLVSKELNDIVRENGTFLEKRINYALDFNYRYFGYKTLENGYLKKIE 162
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHvnersglkaPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 163 GAVAERIQHMLMRVSVGIHGRDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMQDDSIRGIYETLRDCVL 242
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 243 ISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGG-KRKGAMAIYLEPWHADVFDFLNMKRNMGS 321
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 322 EDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYERDELYVRQIQARDLFKFIIETQVET 401
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 402 GTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASICVNKFV------------DVVDDNGG---TY 466
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsKLVGSLGSknrYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 467 DFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALE 546
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 547 ASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSDLWDWSSLKERIKLHGLRNSLLVAYMPTATTAQILGNNESFEPFT 626
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 627 NNIYVRRVLAGEFQVINRYLINDLIKLNLYNDDMRNRIIAANGSIQNIATIPRHIRDLYKTVWEMKSKNLINMAIDRGAF 706
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 529218190 707 IDQSQSFNIFLAKPTYALLTSIHMYAWENGLKTGMYYLRTKPAADAIKFTVDKSSlLKNVDDENLNVES 775
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTAS-LKPSATGVAAPEE 788
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
96-759 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 773.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 96 NLHKKVEGDLVSVTNRLYEHNLVSKELNDivrengtfLEKRINYALDFNYRYFGYKTLENGYLKKIE-GAVAERIQHMLM 174
Cdd:COG0209 8 GQYKSFSEKIKYVEEGLYDERLLEEDLEE--------LAAAIDPERDRFFSYNALKTLYDRYLLKDEdGKPLETPQDLFM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 175 RVSVGIHGRDIVS-----AIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMqDDSIRGIYETLRDCVLISKFGGG 249
Cdd:COG0209 80 RVAMGLAAAEKPEdreewAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDAALLSKSGGG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 250 IGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKRNMGSEDKKARDL 329
Cdd:COG0209 159 VGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 330 LFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYERDELYVRQIQARDLFKFIIETQVETGTPYMLYK 409
Cdd:COG0209 239 NISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 410 DACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASICVNKFVDvvddnGGTYDFERLKHTTKVVVRNLNKIIDVN 489
Cdd:COG0209 319 DTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-----DGEFDWEKLEETVRTAVRFLDNVIDIN 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 490 YYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLG 569
Cdd:COG0209 394 DYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKG 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 570 MLQYDMWNKK--PSDLWDWSSLKERIKLHGLRNSLLVAYMPTATTAQILGNNESFEPFTNNIYVRRVL-AGEFQVINRYL 646
Cdd:COG0209 474 ILPFDKYLDDllIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLdGGEFTVVNPYL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 647 INDLIKLNLYNDDMRNRiIAANGSIQNIATIPRHIRDLYKTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLA-KPTYALL 725
Cdd:COG0209 554 VRALKELGLWDEELVEK-IKEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnDATVEDL 632
|
650 660 670
....*....|....*....|....*....|....
gi 529218190 726 TSIHMYAWENGLKTgMYYLRTKPAADAIKFTVDK 759
Cdd:COG0209 633 AELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
218-743 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 697.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 218 SSCFLVTMqDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGA 297
Cdd:pfam02867 1 SSCFLLSV-EDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 298 MAIYLEPWHADVFDFLNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDEL-YEKYE 376
Cdd:pfam02867 80 AAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYEREE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 377 RDELYVRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASICVNKFV 456
Cdd:pfam02867 160 NEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKFV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 457 dvvdDNGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQI 536
Cdd:pfam02867 240 ----EFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 537 AETIYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSD------LWDWSSLKERIKLHGLRNSLLVAYMPTA 610
Cdd:pfam02867 316 FETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTG 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 611 TTAQILGNNESFEPFTNNIYVRRVLAgefqvinrylindliklnlynddmrnriiaangsiqniatipRHIRDLYKTVWE 690
Cdd:pfam02867 396 SISQIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYD 433
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 529218190 691 MKSKNLINMAIDRGAFIDQSQSFNIFL-AKPTYALLTSIHMYAWENGLKTGMYY 743
Cdd:pfam02867 434 IDQKAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
147-747 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 692.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 147 YFGYKTLENGYLKKIE--GAVAERIQHMLMRVSVGIHG-----RDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSS 219
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAatGAIYESPQEAYMRVAMGLASlepkdTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 220 CFLVTMQDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMA 299
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 300 IYLEPWHADVFDFLNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYERDE 379
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 380 LYV---RQIQARDLFKFIIETQVETGTPYMLYKDACNRK-SNQQNLGTIKCSNLCAEIVEYSDPD---EVAVCNIASICV 452
Cdd:TIGR02506 241 EARkkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVNL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 453 NKFVdvvddNGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLL 532
Cdd:TIGR02506 321 ANFV-----MEDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 533 NQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSDLW-------DWSSLKERIKLHGLRNSLLVA 605
Cdd:TIGR02506 396 NDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTA 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 606 YMPTATTAQILGNNESFEPFTNNIYVRRVLAGEFQVINRYLINDLIKLNLYNDDMRNRIIAANGSIQNIATIPRHIRDLY 685
Cdd:TIGR02506 476 LMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKY 555
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529218190 686 KTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLA-KPTYALLTSIHMYAWENGLKTgMYYLRTK 747
Cdd:TIGR02506 556 KTAYELDQEALIDMAADRQKFVDQSISLNLFLTeEVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
170-746 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 655.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 170 QHMLMRVSVGIHGRDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMqDDSIRGIYETLRDCVLISKFGGG 249
Cdd:cd01679 2 QDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 250 IGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKRNMGSEDKKARDL 329
Cdd:cd01679 81 IGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARDL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 330 LFALWIPDLFMRRVKangvwslmcpdkcrdlsdaygerfdelyekyerdelyvrqiqaRDLFKFIIETQVETGTPYMLYK 409
Cdd:cd01679 161 FYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYILFK 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 410 DACNRKSNQQNLGTIKCSNLCAEIVEYSDP-----DEVAVCNIASICVNKFVDvvddnggtydFERLKHTTKVVVRNLNK 484
Cdd:cd01679 198 DTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT----------FEKLEEVVKLAVRALDN 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 485 IIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGvydsyegs 564
Cdd:cd01679 268 VIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG-------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 565 paslgmlqydmwnkkpsdlwdwsslkeriklhGLRNSLLVAYMPTATTAQILGNNESFEPFTNNIYVRRVLAGEFQVINR 644
Cdd:cd01679 340 --------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNP 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 645 YLINDLIKlnlynddmrnriiaangsiqniatiprhiRDLYKTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLAKP-TYA 723
Cdd:cd01679 388 HLEKDLWE-----------------------------YGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTR 438
|
570 580
....*....|....*....|...
gi 529218190 724 LLTSIHMYAWENGLKTGmYYLRT 746
Cdd:cd01679 439 DLNSLYFYAWKKGLKTL-YYLRT 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
12-775 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1221.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 12 LYVIKRNGRSELIHMDKITRKLQRLSYGLNKEFIDHAAITVRVVKMLYPGVTTEDLDMHAAAETASMAFVHDDYAILAGR 91
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 92 IMVDNLHKKVEGDLVSVTNRLYEH---------NLVSKELNDIVRENGTFLEKRINYALDFNYRYFGYKTLENGYLKKIE 162
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHvnersglkaPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 163 GAVAERIQHMLMRVSVGIHGRDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMQDDSIRGIYETLRDCVL 242
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 243 ISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGG-KRKGAMAIYLEPWHADVFDFLNMKRNMGS 321
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 322 EDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYERDELYVRQIQARDLFKFIIETQVET 401
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 402 GTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASICVNKFV------------DVVDDNGG---TY 466
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsKLVGSLGSknrYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 467 DFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALE 546
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 547 ASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSDLWDWSSLKERIKLHGLRNSLLVAYMPTATTAQILGNNESFEPFT 626
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 627 NNIYVRRVLAGEFQVINRYLINDLIKLNLYNDDMRNRIIAANGSIQNIATIPRHIRDLYKTVWEMKSKNLINMAIDRGAF 706
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 529218190 707 IDQSQSFNIFLAKPTYALLTSIHMYAWENGLKTGMYYLRTKPAADAIKFTVDKSSlLKNVDDENLNVES 775
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTAS-LKPSATGVAAPEE 788
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
96-759 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 773.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 96 NLHKKVEGDLVSVTNRLYEHNLVSKELNDivrengtfLEKRINYALDFNYRYFGYKTLENGYLKKIE-GAVAERIQHMLM 174
Cdd:COG0209 8 GQYKSFSEKIKYVEEGLYDERLLEEDLEE--------LAAAIDPERDRFFSYNALKTLYDRYLLKDEdGKPLETPQDLFM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 175 RVSVGIHGRDIVS-----AIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMqDDSIRGIYETLRDCVLISKFGGG 249
Cdd:COG0209 80 RVAMGLAAAEKPEdreewAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDAALLSKSGGG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 250 IGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKRNMGSEDKKARDL 329
Cdd:COG0209 159 VGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 330 LFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYERDELYVRQIQARDLFKFIIETQVETGTPYMLYK 409
Cdd:COG0209 239 NISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 410 DACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASICVNKFVDvvddnGGTYDFERLKHTTKVVVRNLNKIIDVN 489
Cdd:COG0209 319 DTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-----DGEFDWEKLEETVRTAVRFLDNVIDIN 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 490 YYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLG 569
Cdd:COG0209 394 DYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKG 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 570 MLQYDMWNKK--PSDLWDWSSLKERIKLHGLRNSLLVAYMPTATTAQILGNNESFEPFTNNIYVRRVL-AGEFQVINRYL 646
Cdd:COG0209 474 ILPFDKYLDDllIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLdGGEFTVVNPYL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 647 INDLIKLNLYNDDMRNRiIAANGSIQNIATIPRHIRDLYKTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLA-KPTYALL 725
Cdd:COG0209 554 VRALKELGLWDEELVEK-IKEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnDATVEDL 632
|
650 660 670
....*....|....*....|....*....|....
gi 529218190 726 TSIHMYAWENGLKTgMYYLRTKPAADAIKFTVDK 759
Cdd:COG0209 633 AELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
218-743 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 697.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 218 SSCFLVTMqDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGA 297
Cdd:pfam02867 1 SSCFLLSV-EDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 298 MAIYLEPWHADVFDFLNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDEL-YEKYE 376
Cdd:pfam02867 80 AAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYEREE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 377 RDELYVRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASICVNKFV 456
Cdd:pfam02867 160 NEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKFV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 457 dvvdDNGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQI 536
Cdd:pfam02867 240 ----EFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 537 AETIYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSD------LWDWSSLKERIKLHGLRNSLLVAYMPTA 610
Cdd:pfam02867 316 FETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTG 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 611 TTAQILGNNESFEPFTNNIYVRRVLAgefqvinrylindliklnlynddmrnriiaangsiqniatipRHIRDLYKTVWE 690
Cdd:pfam02867 396 SISQIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYD 433
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 529218190 691 MKSKNLINMAIDRGAFIDQSQSFNIFL-AKPTYALLTSIHMYAWENGLKTGMYY 743
Cdd:pfam02867 434 IDQKAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
147-747 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 692.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 147 YFGYKTLENGYLKKIE--GAVAERIQHMLMRVSVGIHG-----RDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSS 219
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAatGAIYESPQEAYMRVAMGLASlepkdTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 220 CFLVTMQDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMA 299
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 300 IYLEPWHADVFDFLNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYERDE 379
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 380 LYV---RQIQARDLFKFIIETQVETGTPYMLYKDACNRK-SNQQNLGTIKCSNLCAEIVEYSDPD---EVAVCNIASICV 452
Cdd:TIGR02506 241 EARkkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVNL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 453 NKFVdvvddNGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLL 532
Cdd:TIGR02506 321 ANFV-----MEDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 533 NQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSDLW-------DWSSLKERIKLHGLRNSLLVA 605
Cdd:TIGR02506 396 NDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTA 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 606 YMPTATTAQILGNNESFEPFTNNIYVRRVLAGEFQVINRYLINDLIKLNLYNDDMRNRIIAANGSIQNIATIPRHIRDLY 685
Cdd:TIGR02506 476 LMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKY 555
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529218190 686 KTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLA-KPTYALLTSIHMYAWENGLKTgMYYLRTK 747
Cdd:TIGR02506 556 KTAYELDQEALIDMAADRQKFVDQSISLNLFLTeEVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
170-746 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 655.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 170 QHMLMRVSVGIHGRDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMqDDSIRGIYETLRDCVLISKFGGG 249
Cdd:cd01679 2 QDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 250 IGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKRNMGSEDKKARDL 329
Cdd:cd01679 81 IGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARDL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 330 LFALWIPDLFMRRVKangvwslmcpdkcrdlsdaygerfdelyekyerdelyvrqiqaRDLFKFIIETQVETGTPYMLYK 409
Cdd:cd01679 161 FYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYILFK 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 410 DACNRKSNQQNLGTIKCSNLCAEIVEYSDP-----DEVAVCNIASICVNKFVDvvddnggtydFERLKHTTKVVVRNLNK 484
Cdd:cd01679 198 DTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT----------FEKLEEVVKLAVRALDN 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 485 IIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGvydsyegs 564
Cdd:cd01679 268 VIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG-------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 565 paslgmlqydmwnkkpsdlwdwsslkeriklhGLRNSLLVAYMPTATTAQILGNNESFEPFTNNIYVRRVLAGEFQVINR 644
Cdd:cd01679 340 --------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNP 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 645 YLINDLIKlnlynddmrnriiaangsiqniatiprhiRDLYKTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLAKP-TYA 723
Cdd:cd01679 388 HLEKDLWE-----------------------------YGLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTR 438
|
570 580
....*....|....*....|...
gi 529218190 724 LLTSIHMYAWENGLKTGmYYLRT 746
Cdd:cd01679 439 DLNSLYFYAWKKGLKTL-YYLRT 460
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
12-762 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 563.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 12 LYVIKRNGRSELIHMDKITRKLQRLSYGLnkEFIDHAAITVRVVKMLYPGVTTEDLdmHAAAETASMAFVHDD--YAILA 89
Cdd:PRK07207 149 LNVTLDDGVRRPLDMARLRALIEEACEGL--EAVDAEPILAETLKNLYDGVPMDEV--YKALILAARTLIEKEpnYSYVT 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 90 GRIMVDNLHKKVEGDLVSVT-------------------NRLYEHNLVSKELndivrenGTFLEKRINYAL----DFNYR 146
Cdd:PRK07207 225 ARLLLDTLRREALGFLGVPEevtqaematryaeyfpafiKKGIEAELLDPKL-------AQFDLERLGAALdperDLQFT 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 147 YFGYKTLENGYLKKIEGAVAERIQHMLMRVSVGIHGRDI---VSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLV 223
Cdd:PRK07207 298 YLGLQTLYDRYFLHVDGTRIELPQAFFMRVAMGLALNEIdreARAIEFYNLLSSFDFMSSTPTLFNSGTLRPQLSSCYLT 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 224 TMQDDsIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLE 303
Cdd:PRK07207 378 TVPDD-LDGIYEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCAYLE 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 304 PWHADVFDFLNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYE----RDE 379
Cdd:PRK07207 457 TWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGKAFEEAYTAYEakaaRGE 536
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 380 LYV-RQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASI-CVNKFVD 457
Cdd:PRK07207 537 IKLfKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCTEITLNTSDDEIAVCNLGSVnLVAHIKD 616
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 458 vvddnGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIA 537
Cdd:PRK07207 617 -----GAKLDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSM 691
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 538 ETIYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNK-----------KPSDLWDWSSLKERIKLHGLRNSLLVAY 606
Cdd:PRK07207 692 EAVSYYAIWASTELAEERGRYSSYEGSLWSRGILPIDSLKLlaearggylevDRSSTLDWDALRARIKKHGMRNSNCMAI 771
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 607 MPTATTAQILGNNESFEPFTNNIYVRRVLAGEFQVINRYLINDLIKLNLYNDDMRNRIIAANGSIQNIATIPRHIRDLYK 686
Cdd:PRK07207 772 APTATISNIIGVSQSIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDLKYFDGSLQRIDRIPADLKALYA 851
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529218190 687 TVWEMKSKNLINMAIDRGAFIDQSQSFNIFLAKPTYALLTSIHMYAWENGLKTgMYYLRTKPAADAIKFTVDKSSL 762
Cdd:PRK07207 852 TAFEVDPRWLVEAASRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYLRTLGATHVEKSTVNTGAL 926
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
14-760 |
1.09e-163 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 501.78 E-value: 1.09e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 14 VIKRNGRSELIHMDKITRKLQRLSYGLnKEFIDHAAITVRVVKMLYPGVTTEDLDMhaAAETASMAFVHD--DYAILAGR 91
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRF-PETTDAALLADMAFANFYSGIKESEVVL--ACIMAARANIEKepDYAFVAAE 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 92 IMVDNLHKKVEG------DLVSVTNRLYEHNLVSKE---LNDIVRE-NGTFLEKRINYALDFNYRYFGYKTLENGYLKKI 161
Cdd:PRK12365 315 LLLDVVYKEALGkskydeDLEEAHKDHFKRYILEGDtyrLNPELKHyDLDALAEALDLSRDLQFSYMGVQNLYDRYFNHH 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 162 EGAVAERIQHMLMRVSVGI---HGRDIVS-AIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMQDDsIRGIYETL 237
Cdd:PRK12365 395 EGRRLETPQIFWMRVSMGLalnEGQDKTSwAITFYNLLSTFRYTPATPTLFNSGMRHSQLSSCYLSTVQDD-LVHIYKVI 473
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 238 RDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKR 317
Cdd:PRK12365 474 SDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAVCVYLEVWHLDYEDFLELRK 553
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 318 NMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYERD------ELYvRQIQARDLF 391
Cdd:PRK12365 554 NTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYGEEFEKLYEEYERKvdtgeiRLY-KKVEAEDLW 632
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 392 KFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASICVNKFVDvvddnGGTYDFERL 471
Cdd:PRK12365 633 RKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSETETAVCNLGSINLVEHIV-----NDGLDEEKL 707
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 472 KHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNEL 551
Cdd:PRK12365 708 SETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASSLL 787
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 552 AQEFGVYDSYEGSPASLGML-----------------QYDMWNKKpsdlwDWSSLKERIKLHGLRNSLLVAYMPTATTAQ 614
Cdd:PRK12365 788 AKERGTYSSYKGSKWDRGYLpidtiellkeyrgeanlLMDTSSRK-----DWEPVRSLIKEYGMRNSQLMAIAPTATISN 862
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 615 ILGNNESFEPFTNNIYVRRVLAGEFQVINRYLINDLIKLNLYNDDMRNRIIAANGSIQNIATIPRHIRDLYKTVWEMKSK 694
Cdd:PRK12365 863 IIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKKIFLTAFEIEPE 942
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529218190 695 NLINMAIDRGAFIDQSQSFNIFLAKPTYALLTSIHMYAWENGLKTgMYYLRTKPAAdaikfTVDKS 760
Cdd:PRK12365 943 WIIECASRRQKWIDMGQSLNLYLAEPDGKKLSNMYLTAWKKGLKT-TYYLRSSAAT-----SVEKS 1002
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
12-761 |
2.45e-142 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 439.74 E-value: 2.45e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 12 LYVIKRNGRSELIHMDKITRKLQRLSYGLNKEFIDHAAITVRVVKMLYPGVTTEDLDmhAAAETASMAFVHDD--YAILA 89
Cdd:PRK06539 3 ITVVKRDGSKEPYDANKVNAAIEDAARGLDDAITWVTQLASELEITLFDGITTQQLD--EAVIQVALQNVKDDpaFDTVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 90 GRIMVDNLHKKVEGDLVSVTN---------RLYEHNLVSKELNDiVRENGTFLEKRINYALDFN----YRYFGYKTLENG 156
Cdd:PRK06539 81 ARLLLKKIYKRVLGDYDSPEElqdlhanhfRRTIEKGVAEGLLD-SRLGGLFDLERLAAALDPTrdelLKYIGVVTLNNR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 157 Y-LKKIEGAVAERIQHMLMRVSVGIHGRD---IVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMQDDsIRG 232
Cdd:PRK06539 160 YgIRARNGDALEVPQYFWMRIAMGLSLNEddpTSSALAFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQDD-IEH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 233 IYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDF 312
Cdd:PRK06539 239 IAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 313 LNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKY----ERDELYV-RQIQA 387
Cdd:PRK06539 319 LDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKAFSKRYAQYveqaEAGRIRMfKRITA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 388 RDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVEYSDPDEVAVCNIASICVNK-FVDvvddngGTY 466
Cdd:PRK06539 399 REQFRAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRDNVSVCNLASINLSRhLAD------GEL 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 467 DFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALE 546
Cdd:PRK06539 473 DWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAID 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 547 ASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSD-----------LWDWSSLKERIKlHGLRNSLLVAYMPTATTAQI 615
Cdd:PRK06539 553 ESADLAAERGAYPNFEGSRWSRGMVPVDSIALLEADrgvpvdvnrttRLDWDALRAKVR-GGMRNATLMAIAPTASIGLV 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 616 LGNNESFEPFTNNIYVRRVLAGEFQVINRYLINDLIKLNLYnDDMRNRIIAANGSIQNIATIPRHIRDLYKTVWEMKSKN 695
Cdd:PRK06539 632 AGTTPGLDPQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQEIAAIPDEIKALYRTSFQLSPYA 710
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529218190 696 LINMAIDRGAFIDQSQSFNIFLAKPTYALLTSIHMYAWENGLKTgMYYLRTKPAADAIKFT--VDKSS 761
Cdd:PRK06539 711 FLEVAARAQKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAEQSTvkVNKSA 777
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
14-760 |
1.22e-121 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 384.46 E-value: 1.22e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 14 VIKRNGRSELIHMDKITRKLQRLSYGLnkEFIDHAAITVRVVKMLYPGVTTEDLDmHAAAETASMAFVHD--DYAILAGR 91
Cdd:PRK08447 4 VVKRNGRIEPLDISKIQKYTSDAVEGL--EGVSQSELEVDAKIQFRDGITTEEIQ-QTLIKTAVDKIDIDrpNWTFVAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 92 IMVDNLHKKVEGdlVSVTNRLYEHNLVSKELNDIV-----RENGTFLEKRINYALDFNYRYFGYKTLENGYL-KKIEGAV 165
Cdd:PRK08447 81 LFLYDLYHKVSG--FTGYNHLKEYFEKGEKEGRILlglkeKYDLDDLNAYIKPERDLQFNYLGIKTLYDRYLiKDRNNNP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 166 AERIQHMLMRVSVGIHGRDIVS---AIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMQDDsIRGIYETLRDCVL 242
Cdd:PRK08447 159 IELPQHMFMAIAMFLAQNELDPqkwAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCYIGSTPDN-IEGIFDSYKEMAL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 243 ISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKRNMGSE 322
Cdd:PRK08447 238 LSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAIAVYLEPWHMDISDFIDLRKNSGEE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 323 DKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYEKYERDELYVR-QIQARDLFKFIIETQVET 401
Cdd:PRK08447 318 RRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEEFEKRYLEYEKDEKIIKeYINAKELWKKILTNYFET 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 402 GTPYMLYKDACNRKSNQQNLGTIKCSNLCAEI------------VEYSDPDEV--------------------------- 442
Cdd:PRK08447 398 GLPFLCFKDNANRANPNAHAGIIRSSNLCTEIfqntapnhykikIEFEDGSIEffeeeelvtvdsgitkkakkitsldsl 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 443 -----------------AVCNIASICVNKFvdvvddnggtYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRP 505
Cdd:PRK08447 478 kgkkiyivekekkdgktAVCNLASINLSKI----------NTKEDIERVVPIAIRMLDNVIDLNFYPNRKVKATNLKSRA 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 506 VGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSDL-- 583
Cdd:PRK08447 548 IGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPIDKANEEAKKLve 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 584 --------WDWSSLKERIKLHGLRNSLLVAYMPTATTAQILGNNESFEPFTNNIYVRRVLAGefqvinrylindLIKlnl 655
Cdd:PRK08447 628 rgglfdsaCDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKRKWFEENLSG------------LIP--- 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 656 ynddmrnrIIAANGSIQNIAtiprhirdLYKTVWEMKSKNLINMAIDRGAFIDQSQSFNIF--LAKPTYALLTSIHMYAW 733
Cdd:PRK08447 693 --------VVVPNLSPETWQ--------YYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFlsLDKASGKYLNEIYTLAW 756
|
810 820
....*....|....*....|....*..
gi 529218190 734 ENGLKTgMYYLRTKPAADAIKFTVDKS 760
Cdd:PRK08447 757 KLGLKS-TYYLRSESPESEEVSVADRS 782
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
14-746 |
6.15e-108 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 347.48 E-value: 6.15e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 14 VIKRNGRSELIHMDKITRKLQRLSYGLNKefIDHAAITVRVVKMLY--PGVTTEDLDMHAAAETASMAFVHD-DYAILAG 90
Cdd:PRK09209 12 VKEAGNRKLPFDKERLDRYIDQIHAEFPQ--LDVEDYKRRVFNFVErkESVTADDLVDYLIREAEARVDLEEpEWTFFAA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 91 RIMVDNLHKKVE-----------GDLVSVTNRLYEHNLVSKE-LNDIVRENGTFLEKRINYALDFNYRYFGYKTLENGYL 158
Cdd:PRK09209 90 RLYLNRLYKRASrnrfydasekyGSFVGLQESLAERGIYSNDlLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 159 KK-IEGAVAERIQHMLMRVSVGI-----HGRDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMqDDSIRG 232
Cdd:PRK09209 170 ATdSDRNVYELPQERWLTIALYLmqnepRERRMQLVKEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDTV-DDSLQG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 233 IYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDF 312
Cdd:PRK09209 249 IYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 313 LNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRD-----LSDAYGER-----FDELYEKYERDELYV 382
Cdd:PRK09209 329 LDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKKvmgwyLEDFYDEKkgdgsFREKYEECVADERLS 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 383 RQ-IQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIV----------EYSDPDEV--------- 442
Cdd:PRK09209 409 RKtVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSSNLCTEIMqnmsptvmiqEIISGGQIvitkqpgdf 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 443 AVCNIASICVNKFVDvvDDNggtydFERLkhtTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRM 522
Cdd:PRK09209 489 VVCNLSSINLGRAVT--ADV-----LERL---IPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLALKGI 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 523 PYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGmlQYdmWNKKPSDLWDWSSLKERIKLHGLRNSL 602
Cdd:PRK09209 559 AWESEEAVQYADELYERINYLTIQASMELAKEKGAYPVFKGSDWQTG--EY--FERRGYNSPQWDELAAQVAENGVRNAY 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 603 LVAYMPTATTAQILGNNESFEPftnnIYVRrvlagefqvinrylindliklnLYNDDMRNRIIAANGSIQNIATIPRHir 682
Cdd:PRK09209 635 LMAVAPNMSTAQIAGSTASIDP----IYSA----------------------FYYEEKKDYRRPVTAPDLSLDTWPYY-- 686
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 529218190 683 dlYKTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLAKPTYA-LLTSIHMYAWENGLKTgMYYLRT 746
Cdd:PRK09209 687 --EKGAYKVDQFWSIRQNAARQRHVDQSISFNFYVPSTIRAsELLDLHMTAWKEGLKT-TYYVRS 748
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
163-747 |
3.50e-105 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 342.50 E-value: 3.50e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 163 GAVAERIQHMLMRVS--VGIHGRD--IVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMQDdSIRGIYETLR 238
Cdd:PRK12364 255 HEPLESPQEMFLGIAlhLAMPEKQdrMGWVKRFYDMLSKLKVTMATPTLSNARKPFHQLSSCFIDTVPD-SLDGIYRSID 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 239 DCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKRN 318
Cdd:PRK12364 334 NFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTN 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 319 MGSEDKKARDLLFALWIPDLFMRRVK--ANGVWSLMCPD-----KCRDLSDAYGERFDELYEKYERDE-LYVRQIQARDL 390
Cdd:PRK12364 414 NGDDRMKAHDVFPAVCYPDLFWKMVRddINQSWYLFCPHeiltvKGYALEDYYGEEWEKRYLDCVNDArISKRSIPIKDL 493
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 391 FKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEI-----------------------VEYSDPDEVAVCNI 447
Cdd:PRK12364 494 VRLILKSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNLCTEIaqnmsaietvsteietedgdtvvVTTTRPGDFVVCNL 573
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 448 ASICVNKfVDVVDDnggtydfERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESA 527
Cdd:PRK12364 574 ASLSLGN-IDLEDE-------EELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRSIGLGVSGYHHALAKNGIRWESE 645
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 528 EARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGmlQYdmWNKKPSDLWDWSSLKERIKLHGLRNSLLVAYM 607
Cdd:PRK12364 646 EHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTG--AY--FRKRGYTSEEWQRLAREVAENGMRNAYLLAVA 721
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 608 PTATTAQILGNNESFEPftnniyvrrvlagefqVINRYLINDliklnlynddmrnriiaANGSIqniatIPRHIRDLY-K 686
Cdd:PRK12364 722 PTSSTSIIAGTTAGVDP----------------VMKRYFLEE-----------------KKGAL-----MPRVAPELSdK 763
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529218190 687 TVWEMKSKNLIN------MAIDRGAFIDQSQSFNIFLAKP-TYALLTSIHMYAWENGLKTgMYYLRTK 747
Cdd:PRK12364 764 TFWLYKNAHLIDqkwsirAAGVRQRHIDQAQSVNLYITNEfTMRQVLDLYLLAWEEGVKT-IYYVRSK 830
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
136-754 |
5.12e-103 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 330.00 E-value: 5.12e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 136 RINYALDFNYRYFGYKTLENGYLkkIEGavaERIQHMLMRVSVGIHGRDIVSAIETYELMSKQMFTHASPTLFAAGTK-- 213
Cdd:PRK09102 12 NIDRSRDAWLTEFGKATLRDRYL--LEG---ESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGGTDrg 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 214 LPqlSSCFLVTMqDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRStNGTASGLEPMLRVFNNAVRHVDQGGK 293
Cdd:PRK09102 87 LP--ISCFLNYV-EDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPIRN-NGKSSGIIPFIKVMDSLTLAISQGSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 294 RKGAMAIYLEPWHADVFDFLNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDkcrdlsdaygerfdelye 373
Cdd:PRK09102 163 RRGSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISPK------------------ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 374 kyerDELYVRQIQARDLFKFIIETQVETGTPYMLYKDACNRK--SNQQNLG-TIKCSNLCAEI-----VEYSDPDEVAVC 445
Cdd:PRK09102 225 ----DKSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGlKVKASNLCSEItlptgIDHLGEDRTAVC 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 446 NIASICVNKFVDVVDDNGGTYDferlkhttkvVVRNLNKI----IDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLR 521
Cdd:PRK09102 301 CLSSLNLEYYDEWKDTDAFIED----------LMRFLDNVlqdfIDKAPDEMERAKYSAMRERSVGLGVMGFHSYLQSKM 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 522 MPYESAEARLLNQQIAETIYYGALEASNELAQEFGvydsyegspaslgmlqydmwnkKPSDLWDWSSLKeriklhglRNS 601
Cdd:PRK09102 371 IPFESVMAKQWNKKIFKHIREQADKASKELAKEKG----------------------ECPDAAGYGVMR--------RFS 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 602 LLVAYMPTATTAQILGN-NESFEPFTNNIYVRRVLAGEFQVINRYLINDLIKLNLYNDDMRNRIIAANGSIQNIATIPRH 680
Cdd:PRK09102 421 TKMAIAPTASISIILGNtSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKDTDEVWSSILTNEGSVQHLDFLSEE 500
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 529218190 681 IRDLYKTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLAKPTYA-LLTSIHMYAWENGLKTgMYYLRTKPAADAIK 754
Cdd:PRK09102 501 EKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLPANVPKrDLNKLHFEAWKKGVKS-LYYQRSKSVQRADK 574
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
81-747 |
1.53e-100 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 327.92 E-value: 1.53e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 81 VHDDYAILAGRIMVDNLHKKVE----------GDLVSVTNRLYEHNLVSKE-LNDIVRENGTFLEKRINYALDFNYRYFG 149
Cdd:PRK07088 83 TNPNWQYVAARLYVFDLYKEARinrhynsfgyGDYYELVKKLVEEKLYGEYlLQNYSKEEIKELEKYIKPERDFLFNYEG 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 150 YKTLENGYL-KKIEGAVAERIQHMLMRVSVGI-----HGRDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLV 223
Cdd:PRK07088 163 LKLLADRYLvKGFNREILELPQERFMGIAMHLaipegKEKRVYYAKKFYDLLSELKATVATPTLSNAGTPFYQLSSCFIS 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 224 TMqDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLE 303
Cdd:PRK07088 243 VV-DDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITLD 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 304 PWHADVFDFLNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPD-----KCRDLSDAYGERFD-ELYEKY-- 375
Cdd:PRK07088 322 IWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHeikkvKGYSLEDYYDEEDRkEFTKKYle 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 376 --ERDELYVRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEI-------------------- 433
Cdd:PRK07088 402 ceEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIaqnmseselleeeiidengy 481
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 434 ---VEYSDPDEVAVCNIASICVNKfvdvVDDnggtydfERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGV 510
Cdd:PRK07088 482 yevVQKIKAGDMVTCNLNSIVLGN----VDD-------EELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLGT 550
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 511 QGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGmlqyDMWNKKPSDLWDWSSLK 590
Cdd:PRK07088 551 SGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG----KYFERRGYNSERWKKLK 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 591 ERIKLHGLRNSLLVAYMPTATTAQILGNNESFEPftnniyvrrvlagefqVINRYLINDliklnlynddmrnriiaANGS 670
Cdd:PRK07088 627 EEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDP----------------VFKRFFMEE-----------------KKGS 673
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 671 IqniatIPRHIRDL-------YKTVWEMKSKNLINMAIDRGAFIDQSQSFNIFLAkPTYALLTSIHMY--AWENGLKTgM 741
Cdd:PRK07088 674 F-----TPKTAPDLneenfwyYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYIT-PEYKAKQILNLYieAWKQGVKT-I 746
|
....*.
gi 529218190 742 YYLRTK 747
Cdd:PRK07088 747 YYVRNK 752
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
14-760 |
1.72e-95 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 314.35 E-value: 1.72e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 14 VIKRNGRSELIHMDKITRKLQRLSYGLNkefIDHAAITVRVVKMLYPGVTTEDLD---MHAAAETASMAfvHDDYAILAG 90
Cdd:PHA02572 6 VIKSSGVSQPFDLEKIHKVLEWACEGTG---VDPSELEENSKIQLRDGMTTKDIQeilIKSAADLISVE--EPDYQYVAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 91 RIMVDNLHKKVEG--------DLVS--VTNRLYEHNLVSKelndIVRENGTFLEKRINYALDFNYRYFGYKTLENGYL-- 158
Cdd:PHA02572 81 RLLMFALRKQVYGqfeppsfiDHISkcVNEGKYDPEILSK----YSAEEITYLESFIDHDRDFEFTYAGAMQLKEKYLvq 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 159 KKIEGAVAERIQHMLMRVSVGIHGRDIVSA-----IETYELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMqDDSIRGI 233
Cdd:PHA02572 157 DRSTGEIYETPQFAYMLIAMALHQDEPKEDrlehvIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIES-GDSLDSI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 234 YETLRDCV-LISKfGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDF 312
Cdd:PHA02572 236 NKTAMAIVkYISK-RAGIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 313 LNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRD-LSDAYG---ERFDELYEKYERDElYVRQ--IQ 386
Cdd:PHA02572 315 LVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGeLYDAYFadqDRFRELYEALEKDP-SVRKkrIK 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 387 ARDLFKFIIETQVETGTPYMLYKDACNRKSNqqNLGTIKCSNLCAEIV-------EYSDPDEVAVCNIASICVNKFVDVV 459
Cdd:PHA02572 394 AQELFLLLLKERSETGRIYIMFIDHCNNHSP--FKDPIRQSNLCCEIAlptkplnHIDGEGEIALCTLSAIVLGNFEDQD 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 460 ddnggtyDFERLkhtTKVVVRNLNKIIDVNYYPIEAAKASNLRhRPVGVGVQGLADAFTMLRMPYESAEARLLNqQIAET 539
Cdd:PHA02572 472 -------EIEEL---AEVAVRALDNLLDYQDYPVPAALKAKKR-RSLGVGVTNYAHYLAKNFASYEDANADLVH-ELFER 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 540 IYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSDL------WDWSSLKERIKLHGLRNSLLVAYMPTATTA 613
Cdd:PHA02572 540 LQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKKKVDELvapkynCDWESLREDLKKYGIRNSTLSALMPCESSS 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 614 QILGNNESFEPFTNNIYVRRVLAGEF-QVINRYlindliklnlynddmrnriiaangsiqniatipRHIRDLYKTVWEMK 692
Cdd:PHA02572 620 QVSNSTNGIEPPRGPVSIKKSKEGPFnQVVPNV---------------------------------ETLKDLYDLLWDLA 666
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529218190 693 SKN---LINMAIDRGAFIDQSQSFNIFLAKPTY-------ALLTSIHMYAWENGLKTgMYYLRTKPAADAIKFTVDKS 760
Cdd:PHA02572 667 KKGnkgYLTQVAIMQKFVDQAISANTSYDPENYpngkvpmSVMLDDLLYFYYYGGKT-LYYHNTRDGKGTEDYEIETP 743
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
190-625 |
9.57e-93 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 298.38 E-value: 9.57e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 190 ETYELMSKQMFTHASPTLFAAGT-KLPQLSSCFLVTMQDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTN 268
Cdd:cd02888 3 EFFYLLLSQGFIPNSPTLMNAGTgELGQLSACFVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 269 GTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKRNMGSEDkKARDLLFALWIPDLFMRRVKAngv 348
Cdd:cd02888 83 GVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKMKEEKTV-VLQNFNISVAVTDAFMEAVEN--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 349 wslmcpdkcrdlsdaygerfDELYEKYERDELY----VRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTI 424
Cdd:cd02888 159 --------------------DEPWELRNPREPDtgkvYRTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPGLGRI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 425 KCSNLCAEIVEYsdPDEvaVCNIASICVNKFVDvVDDNGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHR 504
Cdd:cd02888 219 NATNPCGEQPLL--PYE--SCNLGSINLSKFVK-NPFGGASFDFERLREAVRLAVRFLDNVIDVNRYPLPEIAEETKATR 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 505 PVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGmLQYDMWNKkpsdlw 584
Cdd:cd02888 294 RIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDASRYLML-KVIVNAKE------ 366
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 529218190 585 DWSSLKERIKLHGLRNSLLVAYMPTATTAQILGNNESFEPF 625
Cdd:cd02888 367 LPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI 407
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
146-738 |
1.53e-91 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 298.85 E-value: 1.53e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 146 RYFgyKTLENGYLKKIEGAVAERIQHMLMRVSvGIHGRDIVSAI--ETYELMSKQMFTHASPTLF-AAGTKLPQLSSCFL 222
Cdd:TIGR02504 5 RYL--LKDEDGNIIESPEDLFRRVARALAAAE-DKYNSPVWKQWyeRFYDLMVNLGFIPNSPTLMnAGGTRLGQLSACFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 223 VTMQDDSIrGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGA-MAIy 301
Cdd:TIGR02504 82 LPVEDSME-DIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAqMGI- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 302 LEPWHADVFDFLNMKRnmgsEDKKARDLLFALWIPDLFMRRVKAngvwslmcpdkcrdlsdaygerfDELYEKYERDELY 381
Cdd:TIGR02504 160 LDVWHPDIEEFIEAKA----KEGKLQNFNISVGVTDEFMEAVEN-----------------------DEEYELRNPRTGE 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 382 VRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVEYsdPDEVavCNIASICVNKFVDVVDD 461
Cdd:TIGR02504 213 YKEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQPLL--PYES--CNLGSINLAKFVKNDFG 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 462 NGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIY 541
Cdd:TIGR02504 289 DEASFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEVMEFIA 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 542 YGALEASNELAQEFGVYDSYEGSPASLGmlqYDMWNKKPSDL-WDwssLKERIKLHGLRNSLLVAYMPTATTAQILGNNE 620
Cdd:TIGR02504 369 DAAYRASAELAKERGAFPLYDASKYPMG---RAMGARIPSALpAE---IREAIRKYGIRNAQLTTIAPTGTISLIAGTSS 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 621 SFEPFTNNIYVRRVLAG-EFQVINRYLINDLIKLNLYNDDMRnRIIAANGSIQNIAtIPRHIRDLYKTVWEMKSKNLINM 699
Cdd:TIGR02504 443 GIEPVFALVYFRNVTVGgELLEVNPLVELALRELGYYSDEIV-KYVDEKGTVEGAP-GPEELPKVFVTAMDISPEDHVLM 520
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 529218190 700 --AIDRgaFIDQSQSFNIFL-AKPTYALLTSIHMYAWENGLK 738
Cdd:TIGR02504 521 qaAIQP--WVDSSISKTINMpSDATVEDVKAVYLEAWKLGLK 560
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
12-751 |
4.34e-73 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 253.76 E-value: 4.34e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 12 LYVIKRNGRSELIHMDKITRKLQRLSYGLNKefidhaaITVRVVKM-----LYPGVTTEDLD---MHAAAETASMAfvHD 83
Cdd:PRK09103 2 LLVTKRDGRTERINLDKIHRVITWAAEGLHN-------VSVSQVELrshiqFYDGIKTSDIHetiIKAAADLISRD--AP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 84 DYAILAGRIMVDNLHKKVEGDLVSvtNRLYEH--NLVSKE------LNDIVRENGTFLEKRINYALDFNYRYFGYKTLEN 155
Cdd:PRK09103 73 DYQYLAARLAIFHLRKKAYGQFEP--PALYDHvvKMVEMGkydkhlLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 156 GYL--KKIEGAVAERIQHMLMRVSVGIHGR-------DIV----SAIETYELmskqmfthASPTLFAAGTKLP--QLSSC 220
Cdd:PRK09103 151 KYLvqNRVTGEIYESAQFLYILVAACLFSNypketrlDYVkrfyDAVSTFKI--------SLPTPIMSGVRTPtrQFSSC 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 221 FLVTMqDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAI 300
Cdd:PRK09103 223 VLIEC-GDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 301 YLEPWHADVFDFLNMKRNMGSEDKKARDLLFALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAY---GERFDELYEKYER 377
Cdd:PRK09103 302 FYPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFfadQDEFERLYTKYEQ 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 378 DE-LYVRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSN-QQNLGTIKCSNLCAEIV-------EYSDPD-EVAVCNI 447
Cdd:PRK09103 382 DDsIRKKRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPKVAPVRQSNLCLEIAlptkplnDVNDENgEIALCTL 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 448 ASICVNKfVDVVDDnggtydferLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESA 527
Cdd:PRK09103 462 SAFNLGA-INSLDE---------LEELADLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDG 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 528 EARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKPSDL------WDWSSLKERIKLHGLRNS 601
Cdd:PRK09103 532 SANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAQGILPIDTYKKDLDAIcneplhYDWETLREEIKTHGLRNS 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 602 LLVAYMPTATTAQILGNNESFEPFTNNIYVRRVLAGefqvINRYLINDLIKLnlynddmrnriiaangsiqniatiprhi 681
Cdd:PRK09103 612 TLSALMPSETSSQISNATNGIEPPRGYVSIKASKDG----ILKQVVPDYERL---------------------------- 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 682 RDLYKTVWEMKSKN--LINMAIDRgAFIDQSQSFNI------FLAK--PTYALLTSIhMYAWENGLKTgMYYLRTKPAAD 751
Cdd:PRK09103 660 KDAYELLWEMPNNDgyLQLVGIMQ-KFVDQSISANTnydpsrFPSGkvPMKQLLKDL-LTAYKFGVKT-LYYHNTRDGAE 736
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
153-687 |
7.80e-73 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 252.93 E-value: 7.80e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 153 LENGYLKKIE-GAVAERIQHMLMRVSVGIHGRDI-------VSAIET--YELMSKQMFTHASPTLFAAGTKLPQLSSCFl 222
Cdd:PRK08665 20 LEKRYLKKDEdGKPIETPEDMFRRVARTIAAAELiydskadVEALADrfYDLMTSLEFLPNSPTLMNAGRELGQLSACF- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 223 VTMQDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGA-MAIy 301
Cdd:PRK08665 99 VLPVGDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGAnMGI- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 302 LEPWHADVFDFLNMKRNmgseDKKARDLLFALWIPDLFMRRVKANGVWSLMCPdkcrdlsdaygerfdelyekyeRDELY 381
Cdd:PRK08665 178 LRVDHPDIMEFITCKED----NGELTNFNISVAITEAFMEAVEADEEYDLINP----------------------RTGEV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 382 VRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAE--IVEYSdpdevaVCNIASICVNKFVdvv 459
Cdd:PRK08665 232 VGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEqpLLPYE------SCNLGSINLSKMV--- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 460 ddNGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAET 539
Cdd:PRK08665 303 --KNGDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKF 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 540 IYYGALEASNELAQEFGVYDSYEGSpaslgmlqydMWNKKpsdlwdwsslkeriKLHGLRNSLLVAYMPTATTAQILGNN 619
Cdd:PRK08665 381 IQDEAHAASRELAEERGPFPNYEGS----------IYDKD--------------GLGPMRNATVTTIAPTGTISIIAGCS 436
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 529218190 620 ESFEPFTNNIYVRRVLAGEFQV-INRYLINDLIKLNLYNDDMRNRiIAANGSIQNIATIPRHIRDLYKT 687
Cdd:PRK08665 437 SGIEPLFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEELMEK-IAEKGSIQDIDEVPEDVRRVFVT 504
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
192-691 |
3.76e-72 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 251.31 E-value: 3.76e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 192 YELMSKQMFTHASPTLFAAGTKLPQLSSCFLVTMqDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTA 271
Cdd:PRK06406 224 EEVMSNLKFVPNSPTLMNAGTKLGQLSACFVLPV-PDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 272 SGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMKrnmGSEDKKARDLLFALWIPDLFMRRVKANGVWSL 351
Cdd:PRK06406 303 SGPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSK---DSENKVLSNFNISVAVTDEFFDKLDNDDYYPL 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 352 MCPdkcrdlsdaygerfdelyekyeRDELYVRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCA 431
Cdd:PRK06406 380 RNP----------------------RNGKEVKRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLGEIESTNPCG 437
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 432 E--IVEYSDpdevavCNIASICVNKFVDvvddnGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVG 509
Cdd:PRK06406 438 EqpLLPYES------CNLGSINLSKFVE-----NGKIDWDRLRETVHIATRFLDNVIDANKFPVPQIKEMTRMTRKIGLG 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 510 VQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSpaslgmlqydmwnkkpsdlwDWSsl 589
Cdd:PRK06406 507 VMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPAWYGS--------------------EWE-- 564
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 590 KERIKlhgLRNSLLVAYMPTATTAQILGNNESFEPFTNNIYVRRVLAG-EFQVINRYLINDLIKLNLYNDDMRnRIIAAN 668
Cdd:PRK06406 565 KKGIK---MRNSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHVLNGqELLEVNPLFEEITRKRGLYSEELM-RKVAET 640
|
490 500
....*....|....*....|...
gi 529218190 669 GSIQNIaTIPRHIRDLYKTVWEM 691
Cdd:PRK06406 641 GNLQNI-DVPEDIKRIFVTAHEI 662
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
191-646 |
4.28e-40 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 159.24 E-value: 4.28e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 191 TYELMSKQmFTHASPTLFAAGTKLP-QLSSCFLVTMQDDSIRGIYETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNG 269
Cdd:PRK08115 160 YQELVNMN-FVPAGRVLYGAGSKTDvTYFNCYVMPFVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNG 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 270 TASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDF------------------------------------- 312
Cdd:PRK08115 239 KSSGSVSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHPDILEFiiskmqnprilryllentedeqikrlvkeklkftpls 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 313 ----------LNMKRNMG-----------SEDKKARDLLFALWIPDL-------------FMRRVKANGVWSLMCPD--- 355
Cdd:PRK08115 319 eveeamyqaiVNYKNIEGqggfdtkvikeAENKLRTGGTYTVNNPEFltganisvcltkeFMEAVENDEEYELRFPDven 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 356 KCRDLSDAYGERFDELYEKYERDEL-----YVRQIQARDLFKFIIETQVETGTPYMLYKDACNRKSNQQNLG-TIKCSNL 429
Cdd:PRK08115 399 YTEEEMEIYNEEWHEVGDVREWEKMgypvrTYRKIKAKELWNLINICATYSAEPGIFFIDNANEMTNAKAYGqKVVATNP 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 430 CAE--IVEYSdpdevaVCNIASICVNKFVDvvdDNGGTYDFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVG 507
Cdd:PRK08115 479 CGEqpLAPYS------VCNLAAINLANMAD---KETKTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVG 549
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 508 VGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASL------GMLQYDMWNKKPS 581
Cdd:PRK08115 550 LGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLVGQTEEEtaklreAFINTGYMKKMPE 629
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 582 DlwdwssLKERIKLHGLRNSLLVAYMPTATTAQILGNNESFEPFTNNIYVRRVLAGEF-----QVINRYL 646
Cdd:PRK08115 630 D------IREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYFSFSYYRSGRLGKFievkaDIVQEYL 693
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
235-641 |
7.70e-36 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 143.78 E-value: 7.70e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 235 ETLRDCVLISKFGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLN 314
Cdd:PRK06948 108 RALDDARLTLLMGGGIGYDFSAIPPADARPDADHPDSPGVCAALDRFDRICAALPFRDGRRGAQMAVLRCDHPDLLAFVA 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 315 MKRNmgsedkKARDLLF--ALWIPDLFMRRVKANGVWSLMCPDKCRDLSDAYGERFDELYekyerdeLYVrQIQARDLFK 392
Cdd:PRK06948 188 AKRG------RARWTTFnlSVAVTDAFMQAVAQDLPWALRHRAPPRRAAGGALRGADGAW-------TYA-TVPARHLWR 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 393 FIIETQVETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAE--IVEYSDpdevavCNIASICVNKFVDVVDDNGGT--YDF 468
Cdd:PRK06948 254 EIVSAARDSAEPGLLFVDTIDAANPLREHERIDATNPCGEqpLPPYGS------CVLGPIDLSRFVRHPFGVGGEprFDF 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 469 ERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEAS 548
Cdd:PRK06948 328 AALATAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAAS 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 549 NELAQEFGVYDSYEGSpASLGMLQYDMWNKKpsdlwdwsSLKERIKLHGLRNSLLVAYMPTATTAQILGNNES--FEPFT 626
Cdd:PRK06948 408 AALAAERGAYPLCDPA-AHLDALRAGPPLPH--------AVCHAIARHGLRNSHLLSFAPVGSVSLAFGDNCSpgIEPAR 478
|
410
....*....|....*
gi 529218190 627 NNIYVRRVLAGEFQV 641
Cdd:PRK06948 479 AWIEHRPVRAGAGGA 493
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
191-671 |
2.09e-30 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 128.93 E-value: 2.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 191 TYELMSkQMFTHASPTLFAAGTKLP-QLSSCFLVTMqDDSIRGIYETLRDCVLISKFGGGIGINVhdvrarnSPIRSTN- 268
Cdd:PRK06556 123 TWLLLH-QKFSFNSPVWFNVGTESPqQVSACFILSV-DDSMESILNWYKEEGMLFKGGSGTGTNL-------SRIRSSKe 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 269 -----GTASGLEPMLRVFNNAVRHVDQGGK-RKGAMAIYLEPWHADVFDFLNMKrnmGSEDKKARDLLFALWIPDL---- 338
Cdd:PRK06556 194 llsggGTASGPVSFMRGADASAGTIKSGGAtRRAAKMVILDVDHPDIEEFIETK---AKEEDKIRALRDAGYDMDLggea 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 339 ------------------FMRRVKANGVWSLMCpdkcrdlsdaygeRFD-ELYEKYErdelyvrqiqARDLFKFIIETQV 399
Cdd:PRK06556 271 yssvqyqnannsvrvsdeFMRAVENDGEFGLRA-------------RTDgEVIETVD----------AKELFRKIAEAAW 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 400 ETGTPYMLYKDACNRKSNQQNLGTIKCSNLCAeivEYSDPDEVAvCNIASICVNKFVDvvDDngGTYDFERLKHTTKVVV 479
Cdd:PRK06556 328 ECADPGIQYDDTINDWHTCPESGRINASNPCS---EYMFLDNSS-CNLASLNLMKFLR--DD--GTFDVESFRHAVELVI 399
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 480 RNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTMLRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYD 559
Cdd:PRK06556 400 TAMEISICFADFPTEKIARNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALAAAITSLMTGEAYRRSAELAGVVGPFE 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 560 SYE-----------------GSPASLGMLQYDMWnKKPSDLWDwSSLKERIKlHGLRNSLLVAYMPTAT--------TAQ 614
Cdd:PRK06556 480 GYArnaephlrvmrkhaaanDAIRPLGEVDAALL-EAAKEAWD-DALELGEK-NGYRNAQASVLAPTGTigfmmdcdTTG 556
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 529218190 615 IlgnnesfEPFTNNI-YVRRVLAGEFQVINRYLINDLIKLNlYNDDMRNRI---IAANGSI 671
Cdd:PRK06556 557 I-------EPDFALVkYKKLVGGGSMKIVNQTVPRALKKLG-YSEEQIEAIveyIAEHGHI 609
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
441-691 |
8.96e-30 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 127.57 E-value: 8.96e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 441 EVAVCNIASICVNKFVDVvDDNGGTY-DFERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLRHRPVGVGVQGLADAFTM 519
Cdd:PRK08332 1304 EYESCNLASINLAKFVKY-DENGKPYfDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFK 1382
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 520 LRMPYESAEARLLNQQIAETIYYGALEASNELAQEFGVYDSYEGSPASLGMLQYDMWNKKpsDLWD--WSSLKERIKLHG 597
Cdd:PRK08332 1383 LGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELPVEGFYHP--EIWNlpWDKLVEEIKKYG 1460
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 598 LRNSLLVAYMPTATTAQILGNNESFEPFTNNIYVRRVLAGEFQVINRYLINDLIKLNLYNDDMRNRIIAANGSIQNIATI 677
Cdd:PRK08332 1461 VRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSEELLKKISDNYGSVQGLEEI 1540
|
250
....*....|....
gi 529218190 678 PRHIRDLYKTVWEM 691
Cdd:PRK08332 1541 PEDMQRVFVTALDI 1554
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
147-213 |
2.45e-18 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 79.97 E-value: 2.45e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529218190 147 YFGYKTLENGYLKKIE-GAVAERIQHMLMRVSVGIHG-----RDIVSAIETYELMSKQMFTHASPTLFAAGTK 213
Cdd:pfam00317 3 YLGAKVLEDRYLLKDEdGELLETPQDMFMRVALALAGaeleeDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
207-570 |
3.15e-12 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 69.10 E-value: 3.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 207 LFAAGTKLPQLSSCFLVT---MQDDSIRGIYETLRDC-------------VLISKFGGGIGINVHDVRARNSPIR---ST 267
Cdd:cd00576 12 VITVGRPDLPFTGCVLVDygdSLDPGIKGVNETAKSIneaiqktyqiialAASNQNGGGVSFARASSILSPYGSRdyaKG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 268 NGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHA-----DVFDFLNMKRNMGSEDKKardllfaLWIPDLFMRr 342
Cdd:cd00576 92 SGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKgkgdkISQEFLNLALANGGEGIP-------LNFPNLSVR- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 343 vkangVWSLMcpdkcrdlsdaygerfdelyekyerdelYVRQIQARDLFKFIIETQVETGTPYMLYKDACNrksnqqnLG 422
Cdd:cd00576 164 -----VSSDK----------------------------PGILVKAVELKQLIAEEARKTGSPGIFNDELCN-------LV 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 423 TIkcsNLcAEIVEYSdpdevavcniasicVNKFVDVVDdnggtydfERLKHTTKVVVRNLNKIIDVNYYPIEAAKASNLR 502
Cdd:cd00576 204 SL---NL-ARIMEKA--------------INGSMDVVL--------EELEELAFLAVRALDCVIDSHDERIPTIELGGDE 257
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 529218190 503 HRPVGVGVQGLADAFTMLRMPY-ESAEARLLNQQIAETIYYGALEASNEL--AQEFGVYDS---YEGSPASLGM 570
Cdd:cd00576 258 RRTVGLGIAGVADLLIKLGLEKvGDPEADDLAAELVDQLKKHLVKATNERgfNFLLGLSPSesnSSGAPATNGV 331
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
12-100 |
5.77e-11 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 59.20 E-value: 5.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 12 LYVIKRNGRSELIHMDKITRKLQRLSYGLNKEfIDHAAITV--RVVKMLYPGVTTEDLD---MHAAAEtasmafvHDDYA 86
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPDQ-ADELASEVeeELEKSLEDGISTEEIQdlvEKTLAE-------HPDYA 72
|
90
....*....|....
gi 529218190 87 ILAGRIMVDNLHKK 100
Cdd:pfam03477 73 VARAYILYRNLRKE 86
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
85-249 |
1.70e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 52.08 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 85 YAILAGRIMVDNLHKKVE-GDLVSVTNRLYEHNLVSKELNDIVRE------NGTFLE--KRINYALD----FNYRY-FGY 150
Cdd:PRK08332 115 FSINALRVLASRYLKKDEnGNIIESPRELFERVAILAVIPDLLYDervfdkNGNYSQdlKRVEYYLEnfeeFDGKYsIGK 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 151 KTLENGYLKKIEGAVAERIQHMLMRVSV---------GIHGRDIVSAIETYELMSKQMFTHASPTLFAAGTKLPQLSSCF 221
Cdd:PRK08332 195 YKLNKYHFERMVNLYRELAEKGKMKVSIdeflkmlerGEFDKYEKEIEEYFRLMTNQIFMPNTPALINSGRPLGMLSACF 274
|
170 180
....*....|....*....|....*...
gi 529218190 222 LVTMQDDsIRGIYETLRDCVLISKFGGG 249
Cdd:PRK08332 275 VVPIEDD-MESIMKAAHDVAMIQKAGGG 301
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
246-430 |
4.88e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 50.53 E-value: 4.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 246 FGGGIGINVHDVRARNSPIRSTNGTASGLEPMLRVFNNAVRHVDQGGKRKGAMAIYLEPWHADVFDFLNMK-RNMGSEDK 324
Cdd:PRK08332 752 FVHNTGLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKeKNIGTNVL 831
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529218190 325 KARDLLFALWipDLFMRRVKANGVWSLMCPDKcrdlsdayGERfdelyekyerdelyVRQIQARDLFKFIIETQVETGTP 404
Cdd:PRK08332 832 SNFNISVGIW--EDFWEALKEGKKYPLINPRT--------GEV--------------VKEIDPKSLFEELAYMAWAKADP 887
|
170 180
....*....|....*....|....*...
gi 529218190 405 YMLYKDACNRKS--NQQNLGTIKCSNLC 430
Cdd:PRK08332 888 GVIFFDVINRRNvlKEAKGGPIRATNPC 915
|
|
| |
