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Conserved domains on  [gi|529217164|ref|YP_008378889|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Avahi laniger]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.13e-70

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 210.04  E-value: 3.13e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   1 MYVVFALSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  81 WGSNVVIWGALLLGLIIELLMVVLMMGHDGLGVEVGFANLENWITFLDKEVGVVREDSLGVTALYGWTSWFIVIAAWSLL 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|..
gi 529217164 161 ISVLIVIEIVRG 172
Cdd:MTH00109 163 IGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.13e-70

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 210.04  E-value: 3.13e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   1 MYVVFALSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  81 WGSNVVIWGALLLGLIIELLMVVLMMGHDGLGVEVGFANLENWITFLDKEVGVVREDSLGVTALYGWTSWFIVIAAWSLL 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|..
gi 529217164 161 ISVLIVIEIVRG 172
Cdd:MTH00109 163 IGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
20-169 1.74e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.58  E-value: 1.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   20 SKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVIWGALLLGLIIEL 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  100 LMVVLMMGHDGLGVEVGFAnlenwitfldkeVGVVREDSLGVtALYGWTSWFIVIAAWSLLISVLIVIEI 169
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAA------------PDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.13e-70

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 210.04  E-value: 3.13e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   1 MYVVFALSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  81 WGSNVVIWGALLLGLIIELLMVVLMMGHDGLGVEVGFANLENWITFLDKEVGVVREDSLGVTALYGWTSWFIVIAAWSLL 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|..
gi 529217164 161 ISVLIVIEIVRG 172
Cdd:MTH00109 163 IGVFVIIEITRG 174
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 7.01e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 114.85  E-value: 7.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   1 MYVVFALSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00138   2 TYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  81 WGSNVViwgallLGLIIELLMVVLMMGHDGLGVEVGFAnlenWITFLD-KEVGVVREDSLGVTALYGWTSWFIVIAAWSL 159
Cdd:MTH00138  82 WGSWSV------LGYVVGYLVGVVLAAGLFWGGWYEGS----WVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                        170
                 ....*....|...
gi 529217164 160 LISVLIVIEIVRG 172
Cdd:MTH00138 152 LLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.35e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 114.18  E-value: 1.35e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   1 MYVVFALSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00065   2 MYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  81 WGSNVVIWgalllgliieLLMVVLMMGHDGLGVEVGFANLENWITFLDKEVGVVREDSLGVTALYGWTSWFIVIAAWSLL 160
Cdd:MTH00065  82 WGSWSVLV----------YVLFYLLLLIVGYILFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLL 151

                        170
                 ....*....|..
gi 529217164 161 ISVLIVIEIVRG 172
Cdd:MTH00065 152 LTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 1.35e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 101.36  E-value: 1.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   1 MYVVFALSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00115   2 MYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  81 WGSNVVIWGALLLGLIIELLMVVLMMGHDGLGVEVGFANLENWitfldkevGVVREDSLGVTALYGWTSWFIVIAAWSLL 160
Cdd:MTH00115  82 WGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGL--------FVVRLDFSGVSLFYSSGGGGLLVCGWGLL 153

                        170
                 ....*....|..
gi 529217164 161 ISVLIVIEIVRG 172
Cdd:MTH00115 154 LTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 2.53e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 71.94  E-value: 2.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   1 MYVVFALSVGFVLGFMSFSSKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00214   2 LYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  81 WGSNVVIWGALLLGLIIELLMVVLMMGHDGLGVEVGfanlenwitfldkeVGVVREDSLGVTALYGWTSWFIVIAAWSLL 160
Cdd:MTH00214  82 WGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGV--------------DEANNLDLSGVSDLYSRGFFLLLLGGVVLF 147

                        170
                 ....*....|..
gi 529217164 161 ISVLIVIEIVRG 172
Cdd:MTH00214 148 LVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 23-172 2.16e-09

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 53.37  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  23 SPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVIwgalllGLIIELLMV 102
Cdd:MTH00045  22 SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPSVSNLGEVL------VLSLLLSLW 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164 103 VLMMGHDGLGVEVGFANLenwitfldkevgVVREDSLGVTALYGWTSWFIVIAAWSLLISVLIVIEIVRG 172
Cdd:MTH00045  96 VFISFDNFLELSNNNWSL------------VSLSDLVGSSELYNSGGLYLLLGGFILLVALVVALVISFG 153
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
20-169 1.74e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.58  E-value: 1.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164   20 SKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVIWGALLLGLIIEL 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217164  100 LMVVLMMGHDGLGVEVGFAnlenwitfldkeVGVVREDSLGVtALYGWTSWFIVIAAWSLLISVLIVIEI 169
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAA------------PDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 1-77 5.98e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 41.14  E-value: 5.98e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529217164   1 MYVVFALSVGFVLGFMsFSSKPSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMATEEY 77
Cdd:MTH00212   1 MLLSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-73 6.51e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 38.33  E-value: 6.51e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529217164   1 MYVVFALSVGFVLGFMSFSSKpSPIYGGVGLIVSGAVGCGIVVSIGGSFVGLVVFLIYLGGMLVVFGYTTAMA 73
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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