non-structural protein V [Human parainfluenza virus 4a]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| zf-Paramyx-P super family | cl15235 | Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such ... |
183-225 | 1.18e-13 | ||
Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation. The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced. The actual alignment was detected with superfamily member pfam13008: Pssm-ID: 372427 Cd Length: 45 Bit Score: 63.24 E-value: 1.18e-13
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| Name | Accession | Description | Interval | E-value | ||
| zf-Paramyx-P | pfam13008 | Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such ... |
183-225 | 1.18e-13 | ||
Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation. The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced. Pssm-ID: 372427 Cd Length: 45 Bit Score: 63.24 E-value: 1.18e-13
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| Name | Accession | Description | Interval | E-value | ||
| zf-Paramyx-P | pfam13008 | Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such ... |
183-225 | 1.18e-13 | ||
Zinc-binding domain of Paramyxoviridae V protein; The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation. The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced. Pssm-ID: 372427 Cd Length: 45 Bit Score: 63.24 E-value: 1.18e-13
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