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Conserved domains on  [gi|529203073|gb|AGS74816|]
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acetyltransferase [Enterococcus faecium Aus0085]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10609153)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  10940244|9175471|15581578
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 5-129 4.21e-45

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


:

Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 143.87  E-value: 4.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073    5 VRELGVSSIEEMFDLATYAFNGADTPERRERFRTLAENSWNYGFFDEeDRLTSQVMATPFPVNFYGQEYLMAGIGYVASY 84
Cdd:pfam13527   1 IRPLTEDEFDEVLRLLEYAFQDEDSPELREYFRPLLEEGRVLGAFDD-GELVSTLALYPFELNVPGKTLPAAGITGVATY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 529203073   85 PEARGQGGINQIMEKILEDCRDRKVSLSYLAPFSYPFYRRYGYEQ 129
Cdd:pfam13527  80 PEYRGRGVMSRLLRRSLEEMRERGVPLSFLYPSSYPIYRRFGYEI 124
 
Name Accession Description Interval E-value
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 5-129 4.21e-45

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 143.87  E-value: 4.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073    5 VRELGVSSIEEMFDLATYAFNGADTPERRERFRTLAENSWNYGFFDEeDRLTSQVMATPFPVNFYGQEYLMAGIGYVASY 84
Cdd:pfam13527   1 IRPLTEDEFDEVLRLLEYAFQDEDSPELREYFRPLLEEGRVLGAFDD-GELVSTLALYPFELNVPGKTLPAAGITGVATY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 529203073   85 PEARGQGGINQIMEKILEDCRDRKVSLSYLAPFSYPFYRRYGYEQ 129
Cdd:pfam13527  80 PEYRGRGVMSRLLRRSLEEMRERGVPLSFLYPSSYPIYRRFGYEI 124
Eis COG4552
Predicted acetyltransferase [General function prediction only];
4-145 1.05e-43

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 148.12  E-value: 1.05e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073   4 KVRELGVSSIEEMFDLATYAFNGADTPERRERFRTLAENSWNYGFFDEeDRLTSQVMATPFPVNFYGQEYLMAGIGYVAS 83
Cdd:COG4552    2 EIRPLTEDDLDAFARLLAYAFGPEPDDEELEAYRPLLEPGRVLGVFDD-GELVGTLALYPFTLNVGGARVPMAGITGVAV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 529203073  84 YPEARGQGGINQIMEKILEDCRDRKVSLSYLAPFSYPFYRRYGYEQSFDKISYQLNSRDVPF 145
Cdd:COG4552   81 APEHRRRGVARALLREALAELRERGQPLSALYPFEPGFYRRFGYELAGDRRRYTIPPESLPL 142
PRK01346 PRK01346
enhanced intracellular survival protein Eis;
1-127 3.32e-06

enhanced intracellular survival protein Eis;


Pssm-ID: 234945 [Multi-domain]  Cd Length: 411  Bit Score: 45.31  E-value: 3.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073   1 MTNKVRELGVSSIEEMFDLATYAFNGADTPERRERFRTLAENSWNYGFFDEeDRLTSQVMATPFPVNFYGQEYL-MAGIG 79
Cdd:PRK01346   5 MAITIRTATEEDWPAWFRAAATGFGDSPSDEELEAWRALVEPDRTLGAFDG-DEVVGTAGAFDLRLTVPGGAVLpAAGVT 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 529203073  80 YVASYPEARGQGGINQIMEKILEDCRDRKVSLSYLAPFSYPFYRRYGY 127
Cdd:PRK01346  84 AVTVAPTHRRRGLLTALMREQLRRIRERGEPVAALTASEGGIYGRFGY 131
 
Name Accession Description Interval E-value
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 5-129 4.21e-45

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 143.87  E-value: 4.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073    5 VRELGVSSIEEMFDLATYAFNGADTPERRERFRTLAENSWNYGFFDEeDRLTSQVMATPFPVNFYGQEYLMAGIGYVASY 84
Cdd:pfam13527   1 IRPLTEDEFDEVLRLLEYAFQDEDSPELREYFRPLLEEGRVLGAFDD-GELVSTLALYPFELNVPGKTLPAAGITGVATY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 529203073   85 PEARGQGGINQIMEKILEDCRDRKVSLSYLAPFSYPFYRRYGYEQ 129
Cdd:pfam13527  80 PEYRGRGVMSRLLRRSLEEMRERGVPLSFLYPSSYPIYRRFGYEI 124
Eis COG4552
Predicted acetyltransferase [General function prediction only];
4-145 1.05e-43

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 148.12  E-value: 1.05e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073   4 KVRELGVSSIEEMFDLATYAFNGADTPERRERFRTLAENSWNYGFFDEeDRLTSQVMATPFPVNFYGQEYLMAGIGYVAS 83
Cdd:COG4552    2 EIRPLTEDDLDAFARLLAYAFGPEPDDEELEAYRPLLEPGRVLGVFDD-GELVGTLALYPFTLNVGGARVPMAGITGVAV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 529203073  84 YPEARGQGGINQIMEKILEDCRDRKVSLSYLAPFSYPFYRRYGYEQSFDKISYQLNSRDVPF 145
Cdd:COG4552   81 APEHRRRGVARALLREALAELRERGQPLSALYPFEPGFYRRFGYELAGDRRRYTIPPESLPL 142
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
5-128 6.05e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 48.54  E-value: 6.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073   5 VRELGVSSIEEMFDLATYAFNGADTPERRERFRtlaENSWNYGFF--DEEDRLTSQVMATPFPVNfygQEYLMAGIGYVA 82
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFGPGREAELVDRLR---EDPAAGLSLvaEDDGEIVGHVALSPVDID---GEGPALLLGPLA 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 529203073  83 SYPEARGQG-GiNQIMEKILEDCRDRKVSLSYL--APFSYPFYRRYGYE 128
Cdd:COG3153   75 VDPEYRGQGiG-RALMRAALEAARERGARAVVLlgDPSLLPFYERFGFR 122
PRK01346 PRK01346
enhanced intracellular survival protein Eis;
1-127 3.32e-06

enhanced intracellular survival protein Eis;


Pssm-ID: 234945 [Multi-domain]  Cd Length: 411  Bit Score: 45.31  E-value: 3.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073   1 MTNKVRELGVSSIEEMFDLATYAFNGADTPERRERFRTLAENSWNYGFFDEeDRLTSQVMATPFPVNFYGQEYL-MAGIG 79
Cdd:PRK01346   5 MAITIRTATEEDWPAWFRAAATGFGDSPSDEELEAWRALVEPDRTLGAFDG-DEVVGTAGAFDLRLTVPGGAVLpAAGVT 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 529203073  80 YVASYPEARGQGGINQIMEKILEDCRDRKVSLSYLAPFSYPFYRRYGY 127
Cdd:PRK01346  84 AVTVAPTHRRRGLLTALMREQLRRIRERGEPVAALTASEGGIYGRFGY 131
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
78-129 2.27e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 39.01  E-value: 2.27e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 529203073  78 IGYVASYPEARGQG-GiNQIMEKILEDCRDR---KVSLS---YLAPFsypfYRRYGYEQ 129
Cdd:COG2153   61 IGRVAVLPEYRGQGlG-RALMEAAIEEARERgarRIVLSaqaHAVGF----YEKLGFVP 114
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 85-137 4.73e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 38.02  E-value: 4.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 529203073   85 PEARGQGGINQIMEKILEDCRDRKVSLSYL----APFSYPFYRRYGY-----EQSFDKISYQ 137
Cdd:pfam13673  61 PDYQGQGIGKALLEAVEDYAEKDGIKLSELtvnaSPYAVPFYEKLGFratgpEQEFNGIRFV 122
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 65-148 8.95e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 37.34  E-value: 8.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529203073  65 PVNFYGQEYLMAGIGYVAS-Y--PEARGQGGINQIMEKILEDCRDRKVSLSYLA-----PFSYPFYRRYGYEqsfdKISY 136
Cdd:COG0454   45 PIGFAGLRRLDDKVLELKRlYvlPEYRGKGIGKALLEALLEWARERGCTALELDtldgnPAAIRFYERLGFK----EIER 120

                         90
                 ....*....|..
gi 529203073 137 QLNSRDVPFIKK 148
Cdd:COG0454  121 YVAYVGGEFEKE 132
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 75-129 9.46e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 37.28  E-value: 9.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 529203073  75 MAGIGYVASYPEARGQGGINQIMEKILEDCRDRKVSLSYL--APFSYPFYRRYGYEQ 129
Cdd:COG1246   52 LAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLltTSAAIHFYEKLGFEE 108
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 80-129 3.47e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 34.74  E-value: 3.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 529203073   80 YVAsyPEARGQG-GiNQIMEKILEDCRDRKVSLSYLAPFSY--PFYRRYGYEQ 129
Cdd:pfam13508  35 AVH--PEYRGQGiG-RALLEAAEAAAKEGGIKLLELETTNRaaAFYEKLGFEE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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