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Conserved domains on  [gi|528749765|gb|AGS43919|]
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Sds22-delta2-56-myc3 [Cloning vector pAG120]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-277 1.21e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 96.78  E-value: 1.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  57 LTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPdsFEGLSNLEEIWLGKN 136
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 137 SIPRLINLHPLKNLKILSIQSNKLKKienleeltnleelylSHNFI---TKIEGLEKNLKltTLDVTSNKITSLENLNHL 213
Cdd:cd21340   79 RISVVEGLENLTNLEELHIENQRLPP---------------GEKLTfdpRSLAALSNSLR--VLNISGNNIDSLEPLAPL 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528749765 214 SNLTDIWASFNKIDqSFESLGENLSALSRLETIYLEGNPIQLENKtsYRRKLTMNlPPSLQKID 277
Cdd:cd21340  142 RNLEQLDASNNQIS-DLEELLDLLSSWPSLRELDLTGNPVCKKPK--YRDKIILA-SKSLEVLD 201
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-277 1.21e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 96.78  E-value: 1.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  57 LTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPdsFEGLSNLEEIWLGKN 136
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 137 SIPRLINLHPLKNLKILSIQSNKLKKienleeltnleelylSHNFI---TKIEGLEKNLKltTLDVTSNKITSLENLNHL 213
Cdd:cd21340   79 RISVVEGLENLTNLEELHIENQRLPP---------------GEKLTfdpRSLAALSNSLR--VLNISGNNIDSLEPLAPL 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528749765 214 SNLTDIWASFNKIDqSFESLGENLSALSRLETIYLEGNPIQLENKtsYRRKLTMNlPPSLQKID 277
Cdd:cd21340  142 RNLEQLDASNNQIS-DLEELLDLLSSWPSLRELDLTGNPVCKKPK--YRDKIILA-SKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-258 5.96e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 5.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765   7 LYRFKNLKQLCLRQNLIESISEvEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLTSLDLSFNKIKHI-KNLENLTDLENL 85
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  86 YFVQNSISKI-ENLSTLKSLKNLELGGNKVHSIePDSFEGLSNLEEIWLGKNSIPRLINLHPLKNLKILSIQSNKLKKIE 164
Cdd:COG4886  188 DLSNNQITDLpEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 165 NLEELTNLEELYLSHNFIT--KIEGLEKNLKLTTLDVTSNKITSLENLNHLSNLTDIWASFNKIDQSFESLGENLSALSR 242
Cdd:COG4886  267 PLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                        250
                 ....*....|....*.
gi 528749765 243 LETIYLEGNPIQLENK 258
Cdd:COG4886  347 LALLTLLLLLNLLSLL 362
LRR_9 pfam14580
Leucine-rich repeat;
63-158 7.33e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.69  E-value: 7.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765   63 LDLSFNKIKHIKNL-ENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRL 141
Cdd:pfam14580  24 LDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL 103

                          90       100
                  ....*....|....*....|
gi 528749765  142 INLHPL---KNLKILSIQSN 158
Cdd:pfam14580 104 GDLDPLaslKKLTFLSLLRN 123
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-251 1.13e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  43 YDNKIKHISSNVNKLTKLTSLDLSFNKIKH--IKNLENLTDLENLYFVQNSISKI--ENLSTLKSLKNLELGGNKVHSIE 118
Cdd:PLN00113 221 YNNLSGEIPYEIGGLTSLNHLDLVYNNLTGpiPSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLSGEI 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 119 PDSFEGLSNLEEIWLGKN----SIPRliNLHPLKNLKILSIQSNKLKKienleeltnleelylshnfitkieGLEKNL-- 192
Cdd:PLN00113 301 PELVIQLQNLEILHLFSNnftgKIPV--ALTSLPRLQVLQLWSNKFSG------------------------EIPKNLgk 354

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528749765 193 --KLTTLDVTSNKITSL--ENLNHLSNLTDIWASFNKIDqsfESLGENLSALSRLETIYLEGN 251
Cdd:PLN00113 355 hnNLTVLDLSTNNLTGEipEGLCSSGNLFKLILFSNSLE---GEIPKSLGACRSLRRVRLQDN 414
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-277 1.21e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 96.78  E-value: 1.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  57 LTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPdsFEGLSNLEEIWLGKN 136
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 137 SIPRLINLHPLKNLKILSIQSNKLKKienleeltnleelylSHNFI---TKIEGLEKNLKltTLDVTSNKITSLENLNHL 213
Cdd:cd21340   79 RISVVEGLENLTNLEELHIENQRLPP---------------GEKLTfdpRSLAALSNSLR--VLNISGNNIDSLEPLAPL 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528749765 214 SNLTDIWASFNKIDqSFESLGENLSALSRLETIYLEGNPIQLENKtsYRRKLTMNlPPSLQKID 277
Cdd:cd21340  142 RNLEQLDASNNQIS-DLEELLDLLSSWPSLRELDLTGNPVCKKPK--YRDKIILA-SKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-258 5.96e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 5.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765   7 LYRFKNLKQLCLRQNLIESISEvEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLTSLDLSFNKIKHI-KNLENLTDLENL 85
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  86 YFVQNSISKI-ENLSTLKSLKNLELGGNKVHSIePDSFEGLSNLEEIWLGKNSIPRLINLHPLKNLKILSIQSNKLKKIE 164
Cdd:COG4886  188 DLSNNQITDLpEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 165 NLEELTNLEELYLSHNFIT--KIEGLEKNLKLTTLDVTSNKITSLENLNHLSNLTDIWASFNKIDQSFESLGENLSALSR 242
Cdd:COG4886  267 PLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                        250
                 ....*....|....*.
gi 528749765 243 LETIYLEGNPIQLENK 258
Cdd:COG4886  347 LALLTLLLLLNLLSLL 362
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-269 2.81e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 2.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765   7 LYRFKNLKQLCLRQNLIESISEvEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLTSLDLSFNKIKHI-KNLENLTDLENL 85
Cdd:COG4886  155 LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  86 YFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSfeGLSNLEEIWLGKNSIPRLiNLHPLKNLKILSIQSNKLKKIEN 165
Cdd:COG4886  234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLLLNL 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 166 LEELTNLEELYLSHNFITKIEGLEKNLKLTTLDVTSNKITSLENLNHLSNLTDIWASFNKIDQSFESLGENLSALSRLET 245
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390

                        250       260
                 ....*....|....*....|....
gi 528749765 246 IYLEGNPIQLENKTSYRRKLTMNL 269
Cdd:COG4886  391 LLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-253 7.70e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 7.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765   1 MLEDLNLYRFKNLKQLCLRQNLIESISEVEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLTSLDLSFNKIKHIKNLE--- 77
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTeld 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  78 --------NLTDLENLYFVQNSISKI-ENLSTLKSLKNLELGGNKVHSIePDSFEGLSNLEEIWLGKNSIPRL-INLHPL 147
Cdd:COG4886  103 lsgneelsNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLpEELGNL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 148 KNLKILSIQSNKLKKIENLEELTNL-EELYLSHNFITKI-EGLEKNLKLTTLDVTSNKITSLENLNHLSNLTDIWASFNK 225
Cdd:COG4886  182 TNLKELDLSNNQITDLPEPLGNLTNlEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQ 261

                        250       260
                 ....*....|....*....|....*...
gi 528749765 226 IDQSFESLGenlsaLSRLETIYLEGNPI 253
Cdd:COG4886  262 LTDLPPLAN-----LTNLKTLDLSNNQL 284
LRR_9 pfam14580
Leucine-rich repeat;
63-158 7.33e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.69  E-value: 7.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765   63 LDLSFNKIKHIKNL-ENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRL 141
Cdd:pfam14580  24 LDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL 103

                          90       100
                  ....*....|....*....|
gi 528749765  142 INLHPL---KNLKILSIQSN 158
Cdd:pfam14580 104 GDLDPLaslKKLTFLSLLRN 123
LRR_8 pfam13855
Leucine rich repeat;
103-160 1.38e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  103 SLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRLIN--LHPLKNLKILSIQSNKL 160
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-254 1.12e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  53 NVNKLTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIW 132
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 133 LGKNSIPRLINLHPLKNLKILSIQSNKlkkieNLEELTNLEELYLSHNFITKI-EGLEKNLKLTTLDVTSNKITSL-ENL 210
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPL 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 528749765 211 NHLSNLTDIWASFNKIdqsfESLGENLSALSRLETIYLEGNPIQ 254
Cdd:COG4886  156 GNLTNLKSLDLSNNQL----TDLPEELGNLTNLKELDLSNNQIT 195
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-251 1.13e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  43 YDNKIKHISSNVNKLTKLTSLDLSFNKIKH--IKNLENLTDLENLYFVQNSISKI--ENLSTLKSLKNLELGGNKVHSIE 118
Cdd:PLN00113 221 YNNLSGEIPYEIGGLTSLNHLDLVYNNLTGpiPSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLSGEI 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 119 PDSFEGLSNLEEIWLGKN----SIPRliNLHPLKNLKILSIQSNKLKKienleeltnleelylshnfitkieGLEKNL-- 192
Cdd:PLN00113 301 PELVIQLQNLEILHLFSNnftgKIPV--ALTSLPRLQVLQLWSNKFSG------------------------EIPKNLgk 354

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528749765 193 --KLTTLDVTSNKITSL--ENLNHLSNLTDIWASFNKIDqsfESLGENLSALSRLETIYLEGN 251
Cdd:PLN00113 355 hnNLTVLDLSTNNLTGEipEGLCSSGNLFKLILFSNSLE---GEIPKSLGACRSLRRVRLQDN 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
6-194 3.10e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765   6 NLYRFKNLKQLCLRQNLIESISEVEVLPhdKIVDLDFYDNKIKHISSNVNkLTKLTSLDLSFNKIKHIKNLENLTDLENL 85
Cdd:COG4886  223 PLANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  86 YFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRLINLHPLKNLKILSIQSNKLKKIEN 165
Cdd:COG4886  300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379

                        170       180
                 ....*....|....*....|....*....
gi 528749765 166 LEELTNLEELYLSHNFITKIEGLEKNLKL 194
Cdd:COG4886  380 LTLALLLLTLLLLLLTTTAGVLLLTLALL 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 6-114 4.80e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 4.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765   6 NLYRFKNLKQLCLRQNLIESISEVEVLPH-----------DKIVDLDFYDNKIKHISSNvnkltkLTSLDLSFNKIKHIK 74
Cdd:cd21340   63 NLENLVNLKKLYLGGNRISVVEGLENLTNleelhienqrlPPGEKLTFDPRSLAALSNS------LRVLNISGNNIDSLE 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 528749765  75 NLENLTDLENLYFVQNSISKIEN----LSTLKSLKNLELGGNKV 114
Cdd:cd21340  137 PLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
PLN03150 PLN03150
hypothetical protein; Provisional
 87-160 5.78e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.64  E-value: 5.78e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528749765  87 FVQNSISKienlstLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRLI--NLHPLKNLKILSIQSNKL 160
Cdd:PLN03150 433 FIPNDISK------LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIpeSLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
82-138 6.73e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 6.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 528749765   82 LENLYFVQNSISKI--ENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSI 138
Cdd:pfam13855   3 LRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 47-253 7.96e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 7.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765  47 IKHISSNvnklTKLTSLDLSFNKIKH------IKNLENLTDLENLYFVQNSISK------IENLSTLKSLKNLELGGNKV 114
Cdd:COG5238  229 AEALKGN----KSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRI 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528749765 115 hsiepdSFEGLSNLeeiwlgknsiprlinlhplknlkilsiqsnklkkienleeltnleelylshnfitkIEGLEKNLKL 194
Cdd:COG5238  305 ------GDEGAIAL--------------------------------------------------------AEGLQGNKTL 322

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528749765 195 TTLDVTSNKITS------LENLNHLSNLTDIWASFNKI-DQSFESLGENLSALSRLETIYLEGNPI 253
Cdd:COG5238  323 HTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIgDEGAIALAKYLEGNTTLRELNLGKNNI 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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