|
Name |
Accession |
Description |
Interval |
E-value |
| NifS |
COG1104 |
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ... |
30-441 |
4.08e-157 |
|
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];
Pssm-ID: 440721 [Multi-domain] Cd Length: 381 Bit Score: 449.50 E-value: 4.08e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 30 RKVYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHS 109
Cdd:COG1104 2 MMIYLDNAATTPVDPEVLEAMLPYLTEYFGNPSSLHSFGREARAALEEAREQVAALLGADPEEIIFTSGGTEANNLAIKG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 110 VVKHFhanqtskghtgghhspvKGAKPHFITSSVEHDSIRLPLEHLvEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTR 189
Cdd:COG1104 82 AARAY-----------------RKKGKHIITSAIEHPAVLETARFL-EKEGFEVTYLPVDE-DGRVDLEALEAALRPDTA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 190 LVTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGAL 268
Cdd:COG1104 143 LVSVMHANNETGTIQPIAEIAEIAKEHG----------VLFHTDAVQAVGKIPVDVKELGVDLLSLSAHKIYGPKgVGAL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 269 YIR-GlgefTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQkrIHLNS 347
Cdd:COG1104 213 YVRkG----VRLEPLIHGGGQERGLRSGTENVPGIVGLGKAAELAAEELEEEAARLRALRDRLEEGLLAAIPG--VVING 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 348 qfPGTQRLPNTCNFSIRGprLQGHVVLAQC--RVLMASVGAACHSDHgDQPSPVLLSYGVPFDVARNALRLSVGRSTTRA 425
Cdd:COG1104 287 --DPENRLPNTLNFSFPG--VEGEALLLALdlAGIAVSSGSACSSGS-LEPSHVLLAMGLDEELAHGSIRFSLGRFTTEE 361
|
410
....*....|....*.
gi 527504087 426 EVDLVVQDLKQAVAQL 441
Cdd:COG1104 362 EIDRAIEALKEIVARL 377
|
|
| PLN02651 |
PLN02651 |
cysteine desulfurase |
32-428 |
9.20e-127 |
|
cysteine desulfurase
Pssm-ID: 178257 [Multi-domain] Cd Length: 364 Bit Score: 371.68 E-value: 9.20e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSP-YSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSV 110
Cdd:PLN02651 1 LYLDMQATTPIDPRVLDAMLPFLIEHFGNPHSRtHLYGWESEDAVEKARAQVAALIGADPKEIIFTSGATESNNLAIKGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 111 VKHFhanqtskghtgghhspvKGAKPHFITSSVEHDSIRLPLEHLVEEqVAAVTFVPVSKvSGQAEVDDILAAVRPTTRL 190
Cdd:PLN02651 81 MHFY-----------------KDKKKHVITTQTEHKCVLDSCRHLQQE-GFEVTYLPVKS-DGLVDLDELAAAIRPDTAL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 191 VTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGALY 269
Cdd:PLN02651 142 VSVMAVNNEIGVIQPVEEIGELCREKK----------VLFHTDAAQAVGKIPVDVDDLGVDLMSISGHKIYGPKgVGALY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 270 IRGlGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQkrIHLNSQF 349
Cdd:PLN02651 212 VRR-RPRVRLEPLMSGGGQERGRRSGTENTPLVVGLGAACELAMKEMDYDEKHMKALRERLLNGLRAKLGG--VRVNGPR 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 527504087 350 PGTQRLPNTCNFSIRGprLQGHVVLAQCRVLMASVGAACHSDhGDQPSPVLLSYGVPFDVARNALRLSVGRSTTRAEVD 428
Cdd:PLN02651 289 DPEKRYPGTLNLSFAY--VEGESLLMGLKEVAVSSGSACTSA-SLEPSYVLRALGVPEEMAHGSLRLGVGRFTTEEEVD 364
|
|
| FeS_nifS |
TIGR03402 |
cysteine desulfurase NifS; Members of this protein family are NifS, one of several related ... |
32-441 |
4.74e-115 |
|
cysteine desulfurase NifS; Members of this protein family are NifS, one of several related families of cysteine desulfurase involved in iron-sulfur (FeS) cluster biosynthesis. NifS is part of the NIF system, usually associated with other nif genes involved in nitrogenase expression and nitrogen fixation. The protein family is given a fairly broad interpretation here. It includes a clade nearly always found in extended nitrogen fixation genomic regions, plus a second clade more closely related to the first than to IscS and also part of NifS-like/NifU-like systems. This model does not extend to a more distantly clade found in the epsilon proteobacteria such as Helicobacter pylori, also named NifS in the literature, built instead in TIGR03403.
Pssm-ID: 132443 [Multi-domain] Cd Length: 379 Bit Score: 342.29 E-value: 4.74e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVV 111
Cdd:TIGR03402 1 IYLDNNATTRVDPEVLEAMLPYFTEYFGNPSSMHSFGGEVGKAVEEAREQVAKLLGAEPDEIIFTSGGTESDNTAIKSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 112 KhfhANQTskghtgghhspvkgaKPHFITSSVEHDSIRLPLEHLvEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTRLV 191
Cdd:TIGR03402 81 A---AQPE---------------KRHIITTAVEHPAVLSLCQHL-EKQGYKVTYLPVDE-EGRLDLEELRAAITDDTALV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 192 TIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGALYI 270
Cdd:TIGR03402 141 SVMWANNETGTIFPIEEIGEIAKERG----------ALFHTDAVQAVGKIPIDLKEMNIDMLSLSGHKLHGPKgVGALYI 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 271 RglgEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFgqKRIHLNSqfP 350
Cdd:TIGR03402 211 R---KGTRFRPLLRGGHQERGRRAGTENVPGIVGLGKAAELATEHLEEENTRVRALRDRLEAGLLARI--PDARLNG--D 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 351 GTQRLPNTCNFSIRGprLQGHVVLaqcrvLM-------ASVGAACHSdhGD-QPSPVLLSYGVPFDVARNALRLSVGRST 422
Cdd:TIGR03402 284 PTKRLPNTVNISFEY--IEGEAIL-----LLldmegicASSGSACTS--GSlEPSHVLRAMGVPHTAAHGSIRFSLSRYN 354
|
410
....*....|....*....
gi 527504087 423 TRAEVDLVVQDLKQAVAQL 441
Cdd:TIGR03402 355 TEEDIDYVLEVLPPIIARL 373
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
32-430 |
8.35e-72 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 230.60 E-value: 8.35e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNP-SSPYSAGRKAKDIINAARESLAKMIGGK-PQDIIFTSGGTESNNLVIHS 109
Cdd:pfam00266 1 IYLDSAATTQKPQEVLDAIQEYYTDYNGNVhRGVHTLGKEATQAYEEAREKVAEFINAPsNDEIIFTSGTTEAINLVALS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 110 VVKHFhanqtskghtgghhspvkGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTR 189
Cdd:pfam00266 81 LGRSL------------------KPGDEIVITEMEHHANLVPWQELAKRTGARVRVLPLDE-DGLLDLDELEKLITPKTK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 190 LVTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGAL 268
Cdd:pfam00266 142 LVAITHVSNVTGTIQPVPEIGKLAHQYG----------ALVLVDAAQAIGHRPIDVQKLGVDFLAFSGHKLYGPTgIGVL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 269 YIR-GLGEFTPlyPMLFGGG--------------QERNFRPGTENTPMIAGLGKAAELVT-QNCEAYEAHMRDVRDYLEE 332
Cdd:pfam00266 212 YGRrDLLEKMP--PLLGGGGmietvslqestfadAPWKFEAGTPNIAGIIGLGAALEYLSeIGLEAIEKHEHELAQYLYE 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 333 RLEAEFGQKRIhlnsqfpGTQRLPNTCNFSIRG--PRLQGHvVLAQcRVLMASVGAAChsdhgdqPSPVLLSYGVPfdva 410
Cdd:pfam00266 290 RLLSLPGIRLY-------GPERRASIISFNFKGvhPHDVAT-LLDE-SGIAVRSGHHC-------AQPLMVRLGLG---- 349
|
410 420
....*....|....*....|
gi 527504087 411 rNALRLSVGRSTTRAEVDLV 430
Cdd:pfam00266 350 -GTVRASFYIYNTQEDVDRL 368
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
32-336 |
4.81e-48 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 168.80 E-value: 4.81e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNPS-SPYSAGRKAKDIINAARESLAKMIGGK-PQDIIFTSGGTESNNLVIHS 109
Cdd:cd06453 1 VYLDNAATSQKPQPVIDAIVDYYRHYNANVHrGVHELSARATDAYEAAREKVARFINAPsPDEIIFTRNTTEAINLVAYG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 110 VVKHFhanqtskghtgghhspvkGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTR 189
Cdd:cd06453 81 LGRAN------------------KPGDEIVTSVMEHHSNIVPWQQLAERTGAKLKVVPVDD-DGQLDLEALEKLLTERTK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 190 LVTIMLANNETGIVMPVPEISQRIKAlnqervaAGLPpILVhtDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGAL 268
Cdd:cd06453 142 LVAVTHVSNVLGTINPVKEIGEIAHE-------AGVP-VLV--DGAQSAGHMPVDVQDLGCDFLAFSGHKMLGPTgIGVL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 269 YIRGlGEFTPLYPMLFGGGQ---------------ERnFRPGTENTPMIAGLGKAAELVT-QNCEAYEAHMRDVRDYLEE 332
Cdd:cd06453 212 YGKE-ELLEEMPPYGGGGEMieevsfeettyadlpHK-FEAGTPNIAGAIGLGAAIDYLEkIGMEAIAAHEHELTAYALE 289
|
....
gi 527504087 333 RLEA 336
Cdd:cd06453 290 RLSE 293
|
|
| f2_encap_cargo1 |
NF041166 |
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like ... |
67-320 |
3.43e-11 |
|
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like encapsulin nanocompartments are commonly found in bacteria and archaea. Encapsulin nanocompartments, which are assembled from shell proteins, encapsulate various cargo proteins, typically peroxidases or ferritin-like proteins, to protect cells from oxidative stress caused by peroxide. Proteins of this family are cysteine desulfurases with an additional N-terminal encapsulation targeting sequence (~200 aa) that is necessary and sufficient for compartmentalization.
Pssm-ID: 469077 [Multi-domain] Cd Length: 623 Bit Score: 65.26 E-value: 3.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 67 AGRkAKDIINAARESLAKMIG-GKPQDIIFTSGGTESNNLVIHS------------VVKHF--HAN-----QTSKghtgg 126
Cdd:NF041166 284 AAR-ATDAYEGAREKVRRFIGaPSVDEIIFVRGTTEAINLVAKSwgrqnigagdeiIVSHLehHANivpwqQLAQ----- 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 127 hhspVKGAKphfitssvehdsIRlplehlveeqVAavtfvPVSKvSGQAEVDDILAAVRPTTRLVTIMLANNETGIVMPV 206
Cdd:NF041166 358 ----ETGAK------------LR----------VI-----PVDD-SGQILLDEYAKLLNPRTKLVSVTQVSNALGTVTPV 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 207 PEISqrikALNQervAAGLPpILVhtDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGALY-IRGLGEFTPLYPmlf 284
Cdd:NF041166 406 KEII----ALAH---RAGAK-VLV--DGAQSVSHMPVDVQALDADFFVFSGHKVFGPTgIGVVYgKRDLLEAMPPWQ--- 472
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 527504087 285 GGGQ-------ER--------NFRPGTENtpmIA---GLGKAAELVTQ----NCEAYE 320
Cdd:NF041166 473 GGGNmiadvtfEKtvyqpapnRFEAGTGN---IAdavGLGAALDYVERigieNIARYE 527
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NifS |
COG1104 |
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ... |
30-441 |
4.08e-157 |
|
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];
Pssm-ID: 440721 [Multi-domain] Cd Length: 381 Bit Score: 449.50 E-value: 4.08e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 30 RKVYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHS 109
Cdd:COG1104 2 MMIYLDNAATTPVDPEVLEAMLPYLTEYFGNPSSLHSFGREARAALEEAREQVAALLGADPEEIIFTSGGTEANNLAIKG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 110 VVKHFhanqtskghtgghhspvKGAKPHFITSSVEHDSIRLPLEHLvEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTR 189
Cdd:COG1104 82 AARAY-----------------RKKGKHIITSAIEHPAVLETARFL-EKEGFEVTYLPVDE-DGRVDLEALEAALRPDTA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 190 LVTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGAL 268
Cdd:COG1104 143 LVSVMHANNETGTIQPIAEIAEIAKEHG----------VLFHTDAVQAVGKIPVDVKELGVDLLSLSAHKIYGPKgVGAL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 269 YIR-GlgefTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQkrIHLNS 347
Cdd:COG1104 213 YVRkG----VRLEPLIHGGGQERGLRSGTENVPGIVGLGKAAELAAEELEEEAARLRALRDRLEEGLLAAIPG--VVING 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 348 qfPGTQRLPNTCNFSIRGprLQGHVVLAQC--RVLMASVGAACHSDHgDQPSPVLLSYGVPFDVARNALRLSVGRSTTRA 425
Cdd:COG1104 287 --DPENRLPNTLNFSFPG--VEGEALLLALdlAGIAVSSGSACSSGS-LEPSHVLLAMGLDEELAHGSIRFSLGRFTTEE 361
|
410
....*....|....*.
gi 527504087 426 EVDLVVQDLKQAVAQL 441
Cdd:COG1104 362 EIDRAIEALKEIVARL 377
|
|
| PLN02651 |
PLN02651 |
cysteine desulfurase |
32-428 |
9.20e-127 |
|
cysteine desulfurase
Pssm-ID: 178257 [Multi-domain] Cd Length: 364 Bit Score: 371.68 E-value: 9.20e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSP-YSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSV 110
Cdd:PLN02651 1 LYLDMQATTPIDPRVLDAMLPFLIEHFGNPHSRtHLYGWESEDAVEKARAQVAALIGADPKEIIFTSGATESNNLAIKGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 111 VKHFhanqtskghtgghhspvKGAKPHFITSSVEHDSIRLPLEHLVEEqVAAVTFVPVSKvSGQAEVDDILAAVRPTTRL 190
Cdd:PLN02651 81 MHFY-----------------KDKKKHVITTQTEHKCVLDSCRHLQQE-GFEVTYLPVKS-DGLVDLDELAAAIRPDTAL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 191 VTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGALY 269
Cdd:PLN02651 142 VSVMAVNNEIGVIQPVEEIGELCREKK----------VLFHTDAAQAVGKIPVDVDDLGVDLMSISGHKIYGPKgVGALY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 270 IRGlGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQkrIHLNSQF 349
Cdd:PLN02651 212 VRR-RPRVRLEPLMSGGGQERGRRSGTENTPLVVGLGAACELAMKEMDYDEKHMKALRERLLNGLRAKLGG--VRVNGPR 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 527504087 350 PGTQRLPNTCNFSIRGprLQGHVVLAQCRVLMASVGAACHSDhGDQPSPVLLSYGVPFDVARNALRLSVGRSTTRAEVD 428
Cdd:PLN02651 289 DPEKRYPGTLNLSFAY--VEGESLLMGLKEVAVSSGSACTSA-SLEPSYVLRALGVPEEMAHGSLRLGVGRFTTEEEVD 364
|
|
| FeS_nifS |
TIGR03402 |
cysteine desulfurase NifS; Members of this protein family are NifS, one of several related ... |
32-441 |
4.74e-115 |
|
cysteine desulfurase NifS; Members of this protein family are NifS, one of several related families of cysteine desulfurase involved in iron-sulfur (FeS) cluster biosynthesis. NifS is part of the NIF system, usually associated with other nif genes involved in nitrogenase expression and nitrogen fixation. The protein family is given a fairly broad interpretation here. It includes a clade nearly always found in extended nitrogen fixation genomic regions, plus a second clade more closely related to the first than to IscS and also part of NifS-like/NifU-like systems. This model does not extend to a more distantly clade found in the epsilon proteobacteria such as Helicobacter pylori, also named NifS in the literature, built instead in TIGR03403.
Pssm-ID: 132443 [Multi-domain] Cd Length: 379 Bit Score: 342.29 E-value: 4.74e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVV 111
Cdd:TIGR03402 1 IYLDNNATTRVDPEVLEAMLPYFTEYFGNPSSMHSFGGEVGKAVEEAREQVAKLLGAEPDEIIFTSGGTESDNTAIKSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 112 KhfhANQTskghtgghhspvkgaKPHFITSSVEHDSIRLPLEHLvEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTRLV 191
Cdd:TIGR03402 81 A---AQPE---------------KRHIITTAVEHPAVLSLCQHL-EKQGYKVTYLPVDE-EGRLDLEELRAAITDDTALV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 192 TIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGALYI 270
Cdd:TIGR03402 141 SVMWANNETGTIFPIEEIGEIAKERG----------ALFHTDAVQAVGKIPIDLKEMNIDMLSLSGHKLHGPKgVGALYI 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 271 RglgEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFgqKRIHLNSqfP 350
Cdd:TIGR03402 211 R---KGTRFRPLLRGGHQERGRRAGTENVPGIVGLGKAAELATEHLEEENTRVRALRDRLEAGLLARI--PDARLNG--D 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 351 GTQRLPNTCNFSIRGprLQGHVVLaqcrvLM-------ASVGAACHSdhGD-QPSPVLLSYGVPFDVARNALRLSVGRST 422
Cdd:TIGR03402 284 PTKRLPNTVNISFEY--IEGEAIL-----LLldmegicASSGSACTS--GSlEPSHVLRAMGVPHTAAHGSIRFSLSRYN 354
|
410
....*....|....*....
gi 527504087 423 TRAEVDLVVQDLKQAVAQL 441
Cdd:TIGR03402 355 TEEDIDYVLEVLPPIIARL 373
|
|
| PRK02948 |
PRK02948 |
IscS subfamily cysteine desulfurase; |
32-436 |
1.46e-85 |
|
IscS subfamily cysteine desulfurase;
Pssm-ID: 179511 [Multi-domain] Cd Length: 381 Bit Score: 266.60 E-value: 1.46e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVV 111
Cdd:PRK02948 2 IYLDYAATTPMSKEALQTYQKAASQYFGNESSLHDIGGTASSLLQVCRKTFAEMIGGEEQGIYFTSGGTESNYLAIQSLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 112 KHFHANqtskghtgghhspvkgaKPHFITSSVEHDSIRLPLEHLvEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTRLV 191
Cdd:PRK02948 82 NALPQN-----------------KKHIITTPMEHASIHSYFQSL-ESQGYTVTEIPVDK-SGLIRLVDLERAITPDTVLA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 192 TIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGALYI 270
Cdd:PRK02948 143 SIQHANSEIGTIQPIAEIGALLKKYN----------VLFHSDCVQTFGKLPIDVFEMGIDSLSVSAHKIYGPKgVGAVYI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 271 RGLGEFTPLYPmlfGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEaefgQKRIHLNSQFP 350
Cdd:PRK02948 213 NPQVRWKPVFP---GTTHEKGFRPGTVNVPGIAAFLTAAENILKNMQEESLRFKELRSYFLEQIQ----TLPLPIEVEGH 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 351 GTQRLPNTCNFSIRGprLQGHVVLAQC--RVLMASVGAACHSdhGDQ-PSPVLLSYGVPFDVARNALRLSVGRSTTRAEV 427
Cdd:PRK02948 286 STSCLPHIIGVTIKG--IEGQYTMLECnrRGIAISTGSACQV--GKQePSKTMLAIGKTYEEAKQFVRFSFGQQTTKDQI 361
|
....*....
gi 527504087 428 DLVVQDLKQ 436
Cdd:PRK02948 362 DTTIHALET 370
|
|
| PRK14012 |
PRK14012 |
IscS subfamily cysteine desulfurase; |
32-443 |
6.79e-83 |
|
IscS subfamily cysteine desulfurase;
Pssm-ID: 184450 [Multi-domain] Cd Length: 404 Bit Score: 260.65 E-value: 6.79e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTK--AMWEAWGNPSS-PYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIH 108
Cdd:PRK14012 5 IYLDYSATTPVDPRVAEKMMPylTMDGTFGNPASrSHRFGWQAEEAVDIARNQIADLIGADPREIVFTSGATESDNLAIK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 109 SVVkHFHANqtsKGHtgghhspvkgakpHFITSSVEHDSIRLPLEHLvEEQVAAVTFVPVsKVSGQAEVDDILAAVRPTT 188
Cdd:PRK14012 85 GAA-HFYQK---KGK-------------HIITSKTEHKAVLDTCRQL-EREGFEVTYLDP-QSNGIIDLEKLEAAMRDDT 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 189 RLVTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGA 267
Cdd:PRK14012 146 ILVSIMHVNNEIGVIQDIAAIGEICRERG----------IIFHVDAAQSVGKVPIDLSKLKVDLMSFSAHKIYGPKgIGA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 268 LYIRGlgefTP---LYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEaefGQKRIH 344
Cdd:PRK14012 216 LYVRR----KPrvrLEAQMHGGGHERGMRSGTLPTHQIVGMGEAARIAKEEMATENERIRALRDRLWNGIK---DIEEVY 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 345 LNSQFpgTQRLPNTCNFSIrgPRLQGHVVLAQCRVLMASVGAACHSdHGDQPSPVLLSYGVPFDVARNALRLSVGRSTTR 424
Cdd:PRK14012 289 LNGDL--EQRVPGNLNVSF--NYVEGESLIMALKDLAVSSGSACTS-ASLEPSYVLRALGLNDELAHSSIRFSLGRFTTE 363
|
410
....*....|....*....
gi 527504087 425 AEVDLVVQDLKQAVAQLED 443
Cdd:PRK14012 364 EEIDYAIELVRKSIGKLRE 382
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
32-430 |
8.35e-72 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 230.60 E-value: 8.35e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNP-SSPYSAGRKAKDIINAARESLAKMIGGK-PQDIIFTSGGTESNNLVIHS 109
Cdd:pfam00266 1 IYLDSAATTQKPQEVLDAIQEYYTDYNGNVhRGVHTLGKEATQAYEEAREKVAEFINAPsNDEIIFTSGTTEAINLVALS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 110 VVKHFhanqtskghtgghhspvkGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTR 189
Cdd:pfam00266 81 LGRSL------------------KPGDEIVITEMEHHANLVPWQELAKRTGARVRVLPLDE-DGLLDLDELEKLITPKTK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 190 LVTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGAL 268
Cdd:pfam00266 142 LVAITHVSNVTGTIQPVPEIGKLAHQYG----------ALVLVDAAQAIGHRPIDVQKLGVDFLAFSGHKLYGPTgIGVL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 269 YIR-GLGEFTPlyPMLFGGG--------------QERNFRPGTENTPMIAGLGKAAELVT-QNCEAYEAHMRDVRDYLEE 332
Cdd:pfam00266 212 YGRrDLLEKMP--PLLGGGGmietvslqestfadAPWKFEAGTPNIAGIIGLGAALEYLSeIGLEAIEKHEHELAQYLYE 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 333 RLEAEFGQKRIhlnsqfpGTQRLPNTCNFSIRG--PRLQGHvVLAQcRVLMASVGAAChsdhgdqPSPVLLSYGVPfdva 410
Cdd:pfam00266 290 RLLSLPGIRLY-------GPERRASIISFNFKGvhPHDVAT-LLDE-SGIAVRSGHHC-------AQPLMVRLGLG---- 349
|
410 420
....*....|....*....|
gi 527504087 411 rNALRLSVGRSTTRAEVDLV 430
Cdd:pfam00266 350 -GTVRASFYIYNTQEDVDRL 368
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
30-439 |
1.67e-52 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 181.11 E-value: 1.67e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 30 RKVYMDYNATTPLEPEVIQAMTKAMWEAWGNPS-SPYSAGRKAKDIINAARESLAKMIGGK-PQDIIFTSGGTESNNLVI 107
Cdd:COG0520 15 PLVYLDNAATGQKPRPVIDAIRDYYEPYNANVHrGAHELSAEATDAYEAAREKVARFIGAAsPDEIIFTRGTTEAINLVA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 108 HSVvKHFHANQtskghtgghhspvkgakpHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKvSGQAEVDDILAAVRPT 187
Cdd:COG0520 95 YGL-GRLKPGD------------------EILITEMEHHSNIVPWQELAERTGAEVRVIPLDE-DGELDLEALEALLTPR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 188 TRLVTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IG 266
Cdd:COG0520 155 TKLVAVTHVSNVTGTVNPVKEIAALAHAHG----------ALVLVDGAQSVPHLPVDVQALGCDFYAFSGHKLYGPTgIG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 267 ALYIRG--LGEftpLYPMLFGGGQ--------------ERNFRPGTENTPMIAGLGKAAELVTQ-NCEAYEAHMRDVRDY 329
Cdd:COG0520 225 VLYGKRelLEA---LPPFLGGGGMiewvsfdgttyadlPRRFEAGTPNIAGAIGLGAAIDYLEAiGMEAIEARERELTAY 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 330 LEERLEAEFGqkrIHLNSQFPGTQRLPnTCNFSIRGprLQGHVV---LAQCRVlmaSVGAACHSDHgdqpsPVLLSYGVP 406
Cdd:COG0520 302 ALEGLAAIPG---VRILGPADPEDRSG-IVSFNVDG--VHPHDVaalLDDEGI---AVRAGHHCAQ-----PLMRRLGVP 367
|
410 420 430
....*....|....*....|....*....|...
gi 527504087 407 fdvarNALRLSVGRSTTRAEVDLVVQDLKQAVA 439
Cdd:COG0520 368 -----GTVRASFHLYNTEEEIDRLVEALKKLAE 395
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
32-336 |
4.81e-48 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 168.80 E-value: 4.81e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDYNATTPLEPEVIQAMTKAMWEAWGNPS-SPYSAGRKAKDIINAARESLAKMIGGK-PQDIIFTSGGTESNNLVIHS 109
Cdd:cd06453 1 VYLDNAATSQKPQPVIDAIVDYYRHYNANVHrGVHELSARATDAYEAAREKVARFINAPsPDEIIFTRNTTEAINLVAYG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 110 VVKHFhanqtskghtgghhspvkGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTTR 189
Cdd:cd06453 81 LGRAN------------------KPGDEIVTSVMEHHSNIVPWQQLAERTGAKLKVVPVDD-DGQLDLEALEKLLTERTK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 190 LVTIMLANNETGIVMPVPEISQRIKAlnqervaAGLPpILVhtDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGAL 268
Cdd:cd06453 142 LVAVTHVSNVLGTINPVKEIGEIAHE-------AGVP-VLV--DGAQSAGHMPVDVQDLGCDFLAFSGHKMLGPTgIGVL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 269 YIRGlGEFTPLYPMLFGGGQ---------------ERnFRPGTENTPMIAGLGKAAELVT-QNCEAYEAHMRDVRDYLEE 332
Cdd:cd06453 212 YGKE-ELLEEMPPYGGGGEMieevsfeettyadlpHK-FEAGTPNIAGAIGLGAAIDYLEkIGMEAIAAHEHELTAYALE 289
|
....
gi 527504087 333 RLEA 336
Cdd:cd06453 290 RLSE 293
|
|
| sufS |
TIGR01979 |
cysteine desulfurases, SufSfamily; This model represents a subfamily of NifS-related cysteine ... |
32-435 |
6.57e-38 |
|
cysteine desulfurases, SufSfamily; This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 131034 [Multi-domain] Cd Length: 403 Bit Score: 142.02 E-value: 6.57e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDyNATTPLEPE-VIQAMTKAMWEAWGNPS-SPYSAGRKAKDIINAARESLAKMIGGK-PQDIIFTSGGTESNNLVIH 108
Cdd:TIGR01979 20 VYLD-SAATSQKPQqVIDAVAEYYRNSNANVHrGIHTLSVRATEAYEAVREKVAKFINAAsDEEIVFTRGTTESINLVAY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 109 SvvkhFHANQTSKGHTgghhspvkgakphFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKvSGQAEVDDILAAVRPTT 188
Cdd:TIGR01979 99 S----WGDSNLKAGDE-------------IVISEMEHHANIVPWQLLAERTGATLKFIPLDD-DGTLDLDDLEKLLTEKT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 189 RLVTIMLANNETGIVMPVPEISQRIKalnqeRVAAglpPILVhtDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGA 267
Cdd:TIGR01979 161 KLVAITHVSNVLGTVNPVEEIAKLAH-----QVGA---KVLV--DGAQAVPHMPVDVQALDCDFYVFSGHKMYGPTgIGV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 268 LYI-RGLGEFTPlyPMLFGGG-------QERNFRP-------GTENTPMIAGLGKAAELVTQ-NCEAYEAHMRDVRDYLE 331
Cdd:TIGR01979 231 LYGkEELLEQMP--PFLGGGEmiaevsfEETTYNEaphkfeaGTPNIAGVIGLGAAIDYLEAiGLENIEAHEHELTAYAL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 332 ERLEaEFGQKRIHlnsqfpGTQRLPN---TCNFSIRG--PRLQGHVVLAQcrvlmasvGAACHS-DHGDQpsPVLLSYGV 405
Cdd:TIGR01979 309 ERLG-EIPGLRIY------GPRDAEDrggIISFNVEGvhPHDVGTILDEE--------GIAVRSgHHCAQ--PLMRRFGV 371
|
410 420 430
....*....|....*....|....*....|
gi 527504087 406 PfdvarNALRLSVGRSTTRAEVDLVVQDLK 435
Cdd:TIGR01979 372 P-----ATCRASFYIYNTEEDIDALVEALK 396
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
32-443 |
6.72e-22 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 97.13 E-value: 6.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDyNATTPLEPeviQAMTKAMWEAWGNPSSPYSAG-----RKAKDIINAARESLAKMIGGK-PQDIIFTSGGTESNNL 105
Cdd:PLN02855 34 VYLD-NAATSQKP---AAVLDALQDYYEEYNSNVHRGihalsAKATDAYELARKKVAAFINAStSREIVFTRNATEAINL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 106 VihsvvkhfhanqtskGHTGGhhspVKGAKP--HFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKvSGQAEVDDILAA 183
Cdd:PLN02855 110 V---------------AYTWG----LANLKPgdEVILSVAEHHSNIVPWQLVAQKTGAVLKFVGLTP-DEVLDVEQLKEL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 184 VRPTTRLVTIMLANNETGIVMPVPEISQRIKAlnqerVAAglpPILVhtDAAQALGKQRVDVEDLGVDFLTIVGHKFYGP 263
Cdd:PLN02855 170 LSEKTKLVATHHVSNVLGSILPVEDIVHWAHA-----VGA---KVLV--DACQSVPHMPVDVQTLGADFLVASSHKMCGP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 264 R-IGALYirGLGEFTPLYPMLFGGGQ-------ERN--------FRPGtenTPMIA---GLGKAAELVT----QNCEAYE 320
Cdd:PLN02855 240 TgIGFLW--GKSDLLESMPPFLGGGEmisdvflDHStyapppsrFEAG---TPAIGeaiGLGAAIDYLSeigmDRIHEYE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 321 ahmRDVRDYLEERLEAEFGQkRIHLNSQFPGTQRLPnTCNFSIRGprLQGHVVlaqCRVLMASVGAACHSDHG-DQPSPV 399
Cdd:PLN02855 315 ---VELGTYLYEKLSSVPGV-RIYGPKPSEGVGRAA-LCAFNVEG--IHPTDL---STFLDQQHGVAIRSGHHcAQPLHR 384
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 527504087 400 LLsyGVPFDvARNALRLsvgrSTTRAEVDLVVQDLKQAVAQLED 443
Cdd:PLN02855 385 YL--GVNAS-ARASLYF----YNTKEEVDAFIHALKDTIAFFSS 421
|
|
| PRK10874 |
PRK10874 |
cysteine desulfurase CsdA; |
32-443 |
1.01e-17 |
|
cysteine desulfurase CsdA;
Pssm-ID: 182799 [Multi-domain] Cd Length: 401 Bit Score: 84.70 E-value: 1.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 32 VYMDyNATTPLEPeviQAMTKAMWEAWGNPS-----SPYSAGRKAKDIINAARESLAKMIGG-KPQDIIFTSGGTESNNL 105
Cdd:PRK10874 21 VYLD-SAATALKP---QAVIEATQQFYSLSAgnvhrSQFAAAQRLTARYEAAREQVAQLLNApDAKNIVWTRGTTESINL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 106 VIHSVvkhfhanqtskghtgghhspvkgAKPHF------ITSSVEHDSIRLPLEHLVEEQVAAVTFVPVskvsGQAEVDD 179
Cdd:PRK10874 97 VAQSY-----------------------ARPRLqpgdeiIVSEAEHHANLVPWLMVAQQTGAKVVKLPL----GADRLPD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 180 I--LAAV-RPTTRLVTIMLANNETGivmPVPEISQRIKALNQervaAGlppILVHTDAAQALGKQRVDVEDLGVDFLTIV 256
Cdd:PRK10874 150 VdlLPELiTPRTRILALGQMSNVTG---GCPDLARAITLAHQ----AG---MVVMVDGAQGAVHFPADVQALDIDFYAFS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 257 GHKFYGPR-IGALYirGLGEFTPLYPMLFGGGQ---------------ERNFRPGTENTPMIAGLGKAAE-LVTQNCEAY 319
Cdd:PRK10874 220 GHKLYGPTgIGVLY--GKSELLEAMSPWQGGGKmltevsfdgftpqsaPWRFEAGTPNVAGVIGLSAALEwLADIDINQA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 320 EAHMRDVRDYLEERLeaefgqkrihlnSQFPGTQ--RLPNTC--NFSIRGPRlqgHVVLAQcrvLMASVGAACHS-DHGD 394
Cdd:PRK10874 298 ESWSRSLATLAEDAL------------AKLPGFRsfRCQDSSllAFDFAGVH---HSDLVT---LLAEYGIALRAgQHCA 359
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 527504087 395 QpsPVLLSYGVPfdvarNALRLSVGRSTTRAEVDLVVQDLKQAVAQLED 443
Cdd:PRK10874 360 Q--PLLAALGVT-----GTLRASFAPYNTQSDVDALVNAVDRALELLVD 401
|
|
| PRK09295 |
PRK09295 |
cysteine desulfurase SufS; |
71-336 |
1.11e-17 |
|
cysteine desulfurase SufS;
Pssm-ID: 181766 [Multi-domain] Cd Length: 406 Bit Score: 84.42 E-value: 1.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 71 AKDIINAARESLAKMIGGK-PQDIIFTSGGTESNNLVIHSVVKHFhanqtskghtgghhspvKGAKPHFITSSVEHDSIR 149
Cdd:PRK09295 65 ATEKMENVRKQAALFINARsAEELVFVRGTTEGINLVANSWGNSN-----------------VRAGDNIIISEMEHHANI 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 150 LPLEHLVEEQVAAVTFVPVSkVSGQAEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQErvaaglppIL 229
Cdd:PRK09295 128 VPWQMLCARVGAELRVIPLN-PDGTLQLETLPALFDERTRLLAITHVSNVLGTENPLAEMIALAHQHGAK--------VL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 230 VhtDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGALYIRG--LGEFTPLYpmlfGGGQ----------------ER 290
Cdd:PRK09295 199 V--DGAQAVMHHPVDVQALDCDFYVFSGHKLYGPTgIGILYVKEalLQEMPPWE----GGGSmiatvsltegttwakaPW 272
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 527504087 291 NFRPGTENTPMIAGLGKAAELVTQ-NCEAYEAHMRDVRDYLEERLEA 336
Cdd:PRK09295 273 RFEAGTPNTGGIIGLGAALDYVSAlGLNNIAEYEQNLMHYALSQLES 319
|
|
| f2_encap_cargo1 |
NF041166 |
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like ... |
67-320 |
3.43e-11 |
|
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like encapsulin nanocompartments are commonly found in bacteria and archaea. Encapsulin nanocompartments, which are assembled from shell proteins, encapsulate various cargo proteins, typically peroxidases or ferritin-like proteins, to protect cells from oxidative stress caused by peroxide. Proteins of this family are cysteine desulfurases with an additional N-terminal encapsulation targeting sequence (~200 aa) that is necessary and sufficient for compartmentalization.
Pssm-ID: 469077 [Multi-domain] Cd Length: 623 Bit Score: 65.26 E-value: 3.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 67 AGRkAKDIINAARESLAKMIG-GKPQDIIFTSGGTESNNLVIHS------------VVKHF--HAN-----QTSKghtgg 126
Cdd:NF041166 284 AAR-ATDAYEGAREKVRRFIGaPSVDEIIFVRGTTEAINLVAKSwgrqnigagdeiIVSHLehHANivpwqQLAQ----- 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 127 hhspVKGAKphfitssvehdsIRlplehlveeqVAavtfvPVSKvSGQAEVDDILAAVRPTTRLVTIMLANNETGIVMPV 206
Cdd:NF041166 358 ----ETGAK------------LR----------VI-----PVDD-SGQILLDEYAKLLNPRTKLVSVTQVSNALGTVTPV 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 207 PEISqrikALNQervAAGLPpILVhtDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPR-IGALY-IRGLGEFTPLYPmlf 284
Cdd:NF041166 406 KEII----ALAH---RAGAK-VLV--DGAQSVSHMPVDVQALDADFFVFSGHKVFGPTgIGVVYgKRDLLEAMPPWQ--- 472
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 527504087 285 GGGQ-------ER--------NFRPGTENtpmIA---GLGKAAELVTQ----NCEAYE 320
Cdd:NF041166 473 GGGNmiadvtfEKtvyqpapnRFEAGTGN---IAdavGLGAALDYVERigieNIARYE 527
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
75-271 |
2.74e-07 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 50.46 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 75 INAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVVK-HFHANQTSKGHTG--GHHSPVKGAKPHFITSSVEHDSIRLP 151
Cdd:cd01494 2 LEELEEKLARLLQPGNDKAVFVPSGTGANEAALLALLGpGDEVIVDANGHGSryWVAAELAGAKPVPVPVDDAGYGGLDV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 152 LEHlvEEQVAAvtfvpvskvsgqaevddilaavrPTTRLVTIMLANNETGIVMPVPEISQRIKALNqervaaglppILVH 231
Cdd:cd01494 82 AIL--EELKAK-----------------------PNVALIVITPNTTSGGVLVPLKEIRKIAKEYG----------ILLL 126
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 527504087 232 TDAAQALG---KQRVDVEDLGVDFLTIVGHK-FYGPRIGALYIR 271
Cdd:cd01494 127 VDAASAGGaspAPGVLIPEGGADVVTFSLHKnLGGEGGGVVIVK 170
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
40-437 |
1.40e-05 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 46.81 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 40 TPLEPEVIQAMTKAM-WEAWGNPSSPYSAGRKAKD-IINAaresLAKMIGGKPQDI--IFTSGGTESNNLVIhsvvkhfH 115
Cdd:cd06450 7 TTMDPPALLLEMLTSaKNAIDFTWDESPAATEMEAeVVNW----LAKLFGLPSEDAdgVFTSGGSESNLLAL-------L 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 116 ANQTSKGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHLVEEqvaaVTFVPVSKVsGQAEVDDILAAVRPTTR--LVTI 193
Cdd:cd06450 76 AARDRARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLDVK----VRLVPVDED-GRMDPEALEAAIDEDKAegLNPI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 194 MLA----NNETGIVMPVPEISqriKALNQErvaaGLPpilVHTDAAQALG------KQRVD--VEdlGVDFLTIVGHKFY 261
Cdd:cd06450 151 MVVatagTTDTGAIDPLEEIA---DLAEKY----DLW---LHVDAAYGGFllpfpePRHLDfgIE--RVDSISVDPHKYG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 262 G--PRIGALYIRGLGeftpLYPMLfgggqeRNFrpGTENtpmiaglgkaaelvtqnceaYEAHMRDVRD---YLEERLEA 336
Cdd:cd06450 219 LvpLGCSAVLVRALK----LWATL------RRF--GRDG--------------------YGEHIDRIVDlakYLAELIRA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527504087 337 EfgqKRIHLNsqfpGTQRLPNTCnFSIRGPRLQGHVVLAQCRVLMAS----VGAACHSDhgdqpspvllsygvpfdvaRN 412
Cdd:cd06450 267 D---PGFELL----GEPNLSLVC-FRLKPSVKLDELNYDLSDRLNERggwhVPATTLGG-------------------PN 319
|
410 420
....*....|....*....|....*.
gi 527504087 413 ALRLSVGRS-TTRAEVDLVVQDLKQA 437
Cdd:cd06450 320 VLRFVVTNPlTTRDDADALLEDIERA 345
|
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