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Conserved domains on  [gi|527498264|ref|NP_001268416|]
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cell division cycle protein 20 homolog B [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-516 4.38e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 4.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKviPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLT--GH 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 401 STAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIATGQGApkNDVALWTCPTL 479
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDD--GTVRLWDLATG 320

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 527498264 480 FRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 516
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-516 4.38e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 4.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKviPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLT--GH 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 401 STAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIATGQGApkNDVALWTCPTL 479
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDD--GTVRLWDLATG 320

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 527498264 480 FRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 516
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-517 3.46e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 3.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 237 LDWSSQN--LVAVALGTSVYIWNgqnhsWIENIDLSVCC-HY--VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNL 311
Cdd:cd00200   15 VAFSPDGklLATGSGDGTIKVWD-----LETGELLRTLKgHTgpVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 312 HGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphdpgAG 389
Cdd:cd00200   90 TGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW-----DL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 390 VQGLPLKVIPQST-AVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAP 467
Cdd:cd00200  165 RTGKCVATLTGHTgEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS--GSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 527498264 468 KNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVWK 517
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 3.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.06e-05
                           10        20
                   ....*....|....*....|....*....
gi 527498264   354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 1.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|....*....
gi 527498264  354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-516 4.38e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 4.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKviPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLT--GH 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 401 STAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPSTQSQ-ICSLIWLPKTKEIATGQGApkNDVALWTCPTL 479
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDD--GTVRLWDLATG 320

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 527498264 480 FRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 516
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
235-516 1.86e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.86e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 235 NTLDWSS--QNLVAVALGTSVYIWNGQNHSWIENIDLsvccH--YVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRN 310
Cdd:COG2319  124 RSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTG----HsgAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 311 LHGHLSVVGALSW--NHCTLSSGSRLGRVHHHDVRvAQHRVGTL-YHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPG 387
Cdd:COG2319  200 LTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLA-TGKLLRTLtGHSGSVRSVAFSPDGRLLASGSADGTVRLW--DLA 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 388 AGVQGLPLKviPQSTAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPS-TQSQICSLIWLPKTKEIATGqgA 466
Cdd:COG2319  277 TGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSD--DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG--S 349

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 527498264 467 PKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 516
Cdd:COG2319  350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
237-516 4.20e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 4.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 237 LDWSSQNLVAVALGTSVYIWNGQNHSWIENIDLSVCCHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLS 316
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 317 VVGALSW--NHCTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGL 393
Cdd:COG2319  122 AVRSVAFspDGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 394 PLKviPQSTAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAPKNDVA 472
Cdd:COG2319  199 TLT--GHTGAVRSVAFSP-DGKLLASGSA--DGTVRLWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLAS--GSADGTVR 271

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 527498264 473 LW-----TCPTLFRsggffGHRDRVLHLSLSPDQTRLFSAAADGTACVW 516
Cdd:COG2319  272 LWdlatgELLRTLT-----GHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-517 3.46e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 3.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 237 LDWSSQN--LVAVALGTSVYIWNgqnhsWIENIDLSVCC-HY--VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNL 311
Cdd:cd00200   15 VAFSPDGklLATGSGDGTIKVWD-----LETGELLRTLKgHTgpVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 312 HGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphdpgAG 389
Cdd:cd00200   90 TGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW-----DL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 390 VQGLPLKVIPQST-AVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAP 467
Cdd:cd00200  165 RTGKCVATLTGHTgEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS--GSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 527498264 468 KNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVWK 517
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
276-516 7.04e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 7.04e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 276 VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVG--ALSWNHCTLSSGSRLGRVHHHDVRVAQHRVGTLY 353
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKviPQSTAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDI 433
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLRTLT--GHSGAVTSVAFSP-DGKLLASGSD--DGTVRLWDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 434 NTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGT 512
Cdd:COG2319  192 ATGKLLRTlTGHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269


                 ....
gi 527498264 513 ACVW 516
Cdd:COG2319  270 VRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-516 8.16e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 8.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 274 HYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW--NHCTLSSGSRlgrvhHHDVRV----AQH 347
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSS-----DKTIRLwdleTGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 348 RVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWPhdpgaGVQGLPLKVIP-QSTAVKAMEWCPwQSEVLAvgGGVKD 425
Cdd:cd00200   85 CVRTLTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWD-----VETGKCLTTLRgHTDWVNSVAFSP-DGTFVA--SSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 426 GCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRL 504
Cdd:cd00200  157 GTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLL 234

                        250
                 ....*....|..
gi 527498264 505 FSAAADGTACVW 516
Cdd:cd00200  235 ASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
288-516 8.52e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 8.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 288 LAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSWNHC--TLSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSP 365
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgaRLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 366 DGRLLSSGCNDGLLTIWPHDPGAGVQGLplkvIPQSTAVKAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQTPST- 444
Cdd:COG2319   89 DGRLLASASADGTVRLWDLATGLLLRTL----TGHTGAVRSVAFSP-DGKTLASGSA--DGTVRLWDLATGKLLRTLTGh 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527498264 445 QSQICSLIWLPKTKEIATGQGApkNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 516
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-516 3.11e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 3.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIWPHDPGAGVQGLPLKVIPqstaVKAMEWCPWQSEVLAVGggvKDGCLHVLDI 433
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP----VRDVAASADGTYLASGS---SDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 434 NTGKNIQT-PSTQSQICSLIWLPKTKEIATGQGApkNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGT 512
Cdd:cd00200   81 ETGECVRTlTGHTSYVSSVAFSPDGRILSSSSRD--KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158


                 ....
gi 527498264 513 ACVW 516
Cdd:cd00200  159 IKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
364-516 1.18e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527498264 364 SPDGRLLSSGCNDGLLTIWPHDPGAGVQGLPLKVIPQSTAVKAmewcpwQSEVLAVGGGVKDGCLHVLDINTGKNIQTPS 443
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAS------PDGARLAAGAGDLTLLLLDAAAGALLATLLG 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 527498264 444 TQSQICSLIWLPKTKEIATGqgAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 516
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 3.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.06e-05
                           10        20
                   ....*....|....*....|....*....
gi 527498264   354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 1.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|....*....
gi 527498264  354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 485-517 1.68e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.68e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 527498264   485 FFGHRDRVLHLSLSPDQTRLFSAAADGTACVWK 517
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
485-516 5.07e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 5.07e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 527498264  485 FFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 516
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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