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Conserved domains on  [gi|527037313|ref|WP_020883967|]
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MFS transporter [Enterobacter ludwigii]

Protein Classification

MFS transporter( domain architecture ID 11484327)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lacY PRK09528
galactoside permease; Reviewed
 3-415 0e+00

galactoside permease; Reviewed


:

Pssm-ID: 236549  Cd Length: 420  Bit Score: 597.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   3 TTTCTHKDNPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLL 82
Cdd:PRK09528   1 MATMYYLKNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  83 WIITVLLFLFAPFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCAST 162
Cdd:PRK09528  81 WIISGLLVLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 163 GGILFGIDPSYVFWMGSAAALLLMLLLVVAKPKPNQTAQVMNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYD 242
Cdd:PRK09528 161 AGILFNINPQINFWLGSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 243 VFDQQFATFFKTFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIA 322
Cdd:PRK09528 241 VFDQQFPNFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 323 LKMLHALEVPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSA 402
Cdd:PRK09528 321 LKLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISV 400

                        410
                 ....*....|...
gi 527037313 403 FTLSSKQEIAARR 415
Cdd:PRK09528 401 FTLSGDRELSLLR 413
 
Name Accession Description Interval E-value
lacY PRK09528
galactoside permease; Reviewed
 3-415 0e+00

galactoside permease; Reviewed


Pssm-ID: 236549  Cd Length: 420  Bit Score: 597.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   3 TTTCTHKDNPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLL 82
Cdd:PRK09528   1 MATMYYLKNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  83 WIITVLLFLFAPFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCAST 162
Cdd:PRK09528  81 WIISGLLVLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 163 GGILFGIDPSYVFWMGSAAALLLMLLLVVAKPKPNQTAQVMNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYD 242
Cdd:PRK09528 161 AGILFNINPQINFWLGSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 243 VFDQQFATFFKTFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIA 322
Cdd:PRK09528 241 VFDQQFPNFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 323 LKMLHALEVPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSA 402
Cdd:PRK09528 321 LKLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISV 400

                        410
                 ....*....|...
gi 527037313 403 FTLSSKQEIAARR 415
Cdd:PRK09528 401 FTLSGDRELSLLR 413
2A0105 TIGR00882
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 11-406 0e+00

oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 211613  Cd Length: 396  Bit Score: 574.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLF 90
Cdd:TIGR00882   1 NTNFWMFGLFFFLYFFIMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   91 LFAPFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCASTGGILFGID 170
Cdd:TIGR00882  81 LFAPFFIYVFGPLLQSNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSID 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  171 PSYVFWMGSAAALLLMLLLVVAKPKPNQTAQVMNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFAT 250
Cdd:TIGR00882 161 PQIVFWLGSGFALILMLLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFAN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  251 FFKTFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALE 330
Cdd:TIGR00882 241 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFE 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 527037313  331 VPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSAFTLS 406
Cdd:TIGR00882 321 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTLS 396
LacY_symp pfam01306
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
 11-416 0e+00

LacY proton/sugar symporter; This family is closely related to the sugar transporter family.


Pssm-ID: 396050  Cd Length: 413  Bit Score: 527.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLF 90
Cdd:pfam01306   6 NTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCITGLLV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   91 LFAPFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCASTGGILFGID 170
Cdd:pfam01306  86 LFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGILFSID 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  171 PSYVFWMGSAAALLLMLLLVVAKPKPNQTAQVMNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFAT 250
Cdd:pfam01306 166 PQIVFWLGSGFALILALLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFDQQFAN 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  251 FFKTFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALE 330
Cdd:pfam01306 246 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKMLHMFE 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  331 VPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSAFTLSSKQE 410
Cdd:pfam01306 326 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTLSGSGP 405


                  ....*.
gi 527037313  411 IAARRA 416
Cdd:pfam01306 406 QILLPR 411
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
 14-405 6.15e-170

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 481.35  E-value: 6.15e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  14 FWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLFLFA 93
Cdd:cd06172    1 YWKFSLFFFLFFFIWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  94 PFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCASTGGILFGIDPSY 173
Cdd:cd06172   81 PFFIFVYGPLLQSNILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 174 VFWMGSAAALLLMLLLVVAKPKPNQTAQvmnALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFK 253
Cdd:cd06172  161 NFWLGSGFALILLLLLLFAKPEDSDTAA---AAGANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 254 TFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALEVPF 333
Cdd:cd06172  238 SLFATPEQGNRVFGYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527037313 334 LLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSAFTL 405
Cdd:cd06172  318 LLVSIFKYITSHFDTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
32-413 1.01e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 72.22  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  32 FPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKhllWIITVLLFLFAPFFLYVFAPLLKSSIWLG 111
Cdd:COG2223   24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLLALAVSYWLLLLLG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 112 ALsGGLYIGFVFSAGSGAIEAYIERVSRNSVFeyGKARMFGCLGWGLCASTGGILFG-IDPSYVFWMGSAAALLLMLLLV 190
Cdd:COG2223  101 LL-LGIGGGGSFAVGIALVSKWFPPDRRGLAL--GLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAW 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 191 VAKPKPnqtaqvmNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFKTFFSTPQEgtrAFGFAT 270
Cdd:COG2223  178 LFLRDP-------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA---TAGLLA 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 271 TAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEV-IALKMLHALEVPFLLVGAFKYITGVFDTR 349
Cdd:COG2223  248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGLALGGGNGAVFALVPDIFPTK 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527037313 350 LSATIYLIGFqFAKQSAAIFLSAFAGNMYDRIG-FQETYLMLGCFVLAITVVSAFTLSSKQEIAA 413
Cdd:COG2223  328 NAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
 
Name Accession Description Interval E-value
lacY PRK09528
galactoside permease; Reviewed
 3-415 0e+00

galactoside permease; Reviewed


Pssm-ID: 236549  Cd Length: 420  Bit Score: 597.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   3 TTTCTHKDNPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLL 82
Cdd:PRK09528   1 MATMYYLKNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  83 WIITVLLFLFAPFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCAST 162
Cdd:PRK09528  81 WIISGLLVLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 163 GGILFGIDPSYVFWMGSAAALLLMLLLVVAKPKPNQTAQVMNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYD 242
Cdd:PRK09528 161 AGILFNINPQINFWLGSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 243 VFDQQFATFFKTFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIA 322
Cdd:PRK09528 241 VFDQQFPNFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 323 LKMLHALEVPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSA 402
Cdd:PRK09528 321 LKLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISV 400

                        410
                 ....*....|...
gi 527037313 403 FTLSSKQEIAARR 415
Cdd:PRK09528 401 FTLSGDRELSLLR 413
2A0105 TIGR00882
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 11-406 0e+00

oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 211613  Cd Length: 396  Bit Score: 574.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLF 90
Cdd:TIGR00882   1 NTNFWMFGLFFFLYFFIMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   91 LFAPFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCASTGGILFGID 170
Cdd:TIGR00882  81 LFAPFFIYVFGPLLQSNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSID 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  171 PSYVFWMGSAAALLLMLLLVVAKPKPNQTAQVMNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFAT 250
Cdd:TIGR00882 161 PQIVFWLGSGFALILMLLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFAN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  251 FFKTFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALE 330
Cdd:TIGR00882 241 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFE 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 527037313  331 VPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSAFTLS 406
Cdd:TIGR00882 321 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTLS 396
LacY_symp pfam01306
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
 11-416 0e+00

LacY proton/sugar symporter; This family is closely related to the sugar transporter family.


Pssm-ID: 396050  Cd Length: 413  Bit Score: 527.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLF 90
Cdd:pfam01306   6 NTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCITGLLV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   91 LFAPFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCASTGGILFGID 170
Cdd:pfam01306  86 LFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGILFSID 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  171 PSYVFWMGSAAALLLMLLLVVAKPKPNQTAQVMNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFAT 250
Cdd:pfam01306 166 PQIVFWLGSGFALILALLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFDQQFAN 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  251 FFKTFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALE 330
Cdd:pfam01306 246 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKMLHMFE 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  331 VPFLLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSAFTLSSKQE 410
Cdd:pfam01306 326 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTLSGSGP 405


                  ....*.
gi 527037313  411 IAARRA 416
Cdd:pfam01306 406 QILLPR 411
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
 14-405 6.15e-170

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 481.35  E-value: 6.15e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  14 FWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLFLFA 93
Cdd:cd06172    1 YWKFSLFFFLFFFIWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  94 PFFLYVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCASTGGILFGIDPSY 173
Cdd:cd06172   81 PFFIFVYGPLLQSNILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 174 VFWMGSAAALLLMLLLVVAKPKPNQTAQvmnALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFK 253
Cdd:cd06172  161 NFWLGSGFALILLLLLLFAKPEDSDTAA---AAGANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 254 TFFSTPQEGTRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALEVPF 333
Cdd:cd06172  238 SLFATPEQGNRVFGYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527037313 334 LLVGAFKYITGVFDTRLSATIYLIGFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSAFTL 405
Cdd:cd06172  318 LLVSIFKYITSHFDTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 27-403 1.26e-17

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 83.79  E-value: 1.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  27 IMATCFPFLPIWLSDvIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLFLFAPFFLYVFApllks 106
Cdd:cd17335   12 ALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQ----- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 107 SIWLGALSGGLYIgFVFSAGSGAIEAYIERVSRNSVFEYGKARMFGCLGWGLCASTGGILFG-----IDPSYVFWMGSAA 181
Cdd:cd17335   86 IFWLLLLLVILGA-FFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDrsstyKNYTIAFYVFAVL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 182 ALLLMLLLVVAKPKPNQTaqvmnalganQPQITARTVFNLFRQRRMWMFILYVigvacvydVFDQQFATFFKTFFS---T 258
Cdd:cd17335  165 MLLALLLALKFPFRPKHP----------EPNENTGGLLALLRNPRVLAFLLVA--------FLMGFGHGLIYSFLFwhlQ 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 259 PQEGTR-AFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALEVPFLLVG 337
Cdd:cd17335  227 DLGGSKtLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAA 306

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 338 AFKYITGVFDTRLSAT----IYLIGFQFAKQSAAIflsaFAGNMYDRIGFQETYLMLGCFVLAITVVSAF 403
Cdd:cd17335  307 AVSYASAAAPPGLRATaqglLQGLYFGLGGGLGSL----IGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
32-413 1.01e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 72.22  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  32 FPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKhllWIITVLLFLFAPFFLYVFAPLLKSSIWLG 111
Cdd:COG2223   24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLLALAVSYWLLLLLG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 112 ALsGGLYIGFVFSAGSGAIEAYIERVSRNSVFeyGKARMFGCLGWGLCASTGGILFG-IDPSYVFWMGSAAALLLMLLLV 190
Cdd:COG2223  101 LL-LGIGGGGSFAVGIALVSKWFPPDRRGLAL--GLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAW 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 191 VAKPKPnqtaqvmNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFKTFFSTPQEgtrAFGFAT 270
Cdd:COG2223  178 LFLRDP-------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA---TAGLLA 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 271 TAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEV-IALKMLHALEVPFLLVGAFKYITGVFDTR 349
Cdd:COG2223  248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGLALGGGNGAVFALVPDIFPTK 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 527037313 350 LSATIYLIGFqFAKQSAAIFLSAFAGNMYDRIG-FQETYLMLGCFVLAITVVSAFTLSSKQEIAA 413
Cdd:COG2223  328 NAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 33-403 2.77e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 58.59  E-value: 2.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  33 PFLPIWLSDViGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLFlfapfflyVFAPLLKSSIWLGA 112
Cdd:cd06174   17 PLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFAL--------GALLFAFAPSFWLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 113 LSGGLYIGFVFSAGSGAIEAYIERVS--RNSVFEYGKARMFGCLGWGLCASTGGILFGIDPSYVFWMGSAAALLLMLLLV 190
Cdd:cd06174   88 LLGRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 191 VAKPKPNQTAQvmNALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFKTFFSTPQEGTRAFGFAT 270
Cdd:cd06174  168 LLLLVVPDPPE--SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 271 TAGEICNAIIMFCSPWIINR-IGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALEVPFLLVGAFKYITGVFDTR 349
Cdd:cd06174  246 SLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPE 325

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 527037313 350 LSATIYLIgFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSAF 403
Cdd:cd06174  326 IRGTAFGL-LNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 32-403 3.28e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 55.27  E-value: 3.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  32 FPFLPIWLSDvIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVllfLFAPFFLYVFAPllksSIWLG 111
Cdd:cd17325   16 IPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLL---LAVSTLLFAFAT----SYWQL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 112 ALS---GGLYIGFVFSAGSGAIEAYIERVSRNSVFeyGKARMFGCLGWGLCASTGGILFG-IDPSYVFWMGSAAALLLML 187
Cdd:cd17325   88 LLArflQGLASAAVWPAAMALIADIAPPEERGRAM--GIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 188 LLVVAKPKPNQTAqvmnALGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFKTFFSTpqeGTRAFG 267
Cdd:cd17325  166 LALLLLPEPRPPP----NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL---SPAQIG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 268 FATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALEVPFLLVGAFKYITGVFD 347
Cdd:cd17325  239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 527037313 348 TRLSATIYLIgFQFAKQSAAIFLSAFAGNMYDRIGFQETYLMLGCFVLAITVVSAF 403
Cdd:cd17325  319 PEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 32-176 1.48e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.92  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  32 FPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLFLFAPFFLYVFAPLLKSSIWLG 111
Cdd:cd17329   19 WPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLT 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 527037313 112 ALSGGLYIgfvfsagsGAIEAYIERVSRNSVFEYGKA--RMFGCLGWGLCASTGGILFGIDPSYVFW 176
Cdd:cd17329   99 GFGGGLFE--------PASEAMIADVTTPENRTRAFSllYWAINLGVAIGPLLGGLLLLYSFRLLFL 157
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 11-179 2.08e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.50  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKhllWIITVLLF 90
Cdd:cd17325  198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP---LILIGLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  91 LFAPFFLYVFAPLLKSSIWLGALSGGLYiGFVFSAGSGAIEAYIERVSRNSVfeYGKARMFGCLGWGLCASTGGILFG-I 169
Cdd:cd17325  275 SAVALLLLPLATSFWLLLLLLALLGLGL-GLVFPATLALLADIVPPEGRGTA--MGLFNTAFSLGMVLGPLLGGFLYDaF 351

                        170
                 ....*....|
gi 527037313 170 DPSYVFWMGS 179
Cdd:cd17325  352 GFATPFLAAA 361
MFS_1 pfam07690
Major Facilitator Superfamily;
32-323 3.41e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.57  E-value: 3.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   32 FPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLFLfapfflyVFAPLLKSSIWLG 111
Cdd:pfam07690  16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALG-------LLLLLFASSLWLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  112 ALSG---GLYIGFVFSAGSGAIEAYIERVSRNSVFeyGKARMFGCLGWGLCASTGGILFG-IDPSYVFWMGSAAALLLML 187
Cdd:pfam07690  89 LVLRvlqGLGAGALFPAALALIADWFPPEERGRAL--GLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  188 LLVVAKPKPNQTAQvmnaLGANQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFKTFFSTPQEGTRAFG 267
Cdd:pfam07690 167 LLLLPRPPPESKRP----KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLG 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 527037313  268 FATTAGeicnAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIAL 323
Cdd:pfam07690 243 LGGLLG----AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-354 6.18e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.05  E-value: 6.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  33 PFLPiWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLFLfapfflYVFAPLLKSSIWLGA 112
Cdd:COG2814   31 PALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG------SLLCALAPSLWLLLA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 113 LS--GGLYIGFVFSAGSGAIEAYIERVSRNSVFeyGKARMFGCLGWGLCASTGGILFG-IDPSYVFWMGSAAALLLMLLL 189
Cdd:COG2814  104 ARflQGLGAGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 190 VVAKPKPNQTAqvmnalganqPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFKTFFSTPQEgtrAFGFA 269
Cdd:COG2814  182 LRLLPESRPAA----------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS---AAGLL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 270 TTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALEVPFLLVGAFKYITGVFDTR 349
Cdd:COG2814  249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPE 328


                 ....*
gi 527037313 350 LSATI 354
Cdd:COG2814  329 ARGRA 333
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 32-329 3.87e-05

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 45.31  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313   32 FPFLPIWLSDvIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKhllWIITVLLFLFAPFFLYVFAPLLKSSIWLG 111
Cdd:pfam12832  19 LPYWGLYLRS-IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRK---AVVRLASILAAVLFLSVLFIPISLTFWWL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  112 ALsgglyIGFVFSAGSGAIEAYIERVS----RNSVFEYGKARMFGCLGWGLCASTGGILF-----GIDPSYVFWMGSAAA 182
Cdd:pfam12832  95 AL-----LVVLFSFFWNAILPQFEVATlqhlGEKRKDYGRQRLWGSVGFALSVFGLGALFdhysvGLLPSVLFYLFAALM 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  183 LLLMLLLVVAKPKPNQTAQVMnalganqpqitARTVFNLFRQRRMWMFILyvigVACVYDVFDQQFATFFKTFFSTPQEG 262
Cdd:pfam12832 170 LLSLLLPLAPPEMEYESKGGS-----------KAVFWNLLKQPEVIIFFL----AAFLLGFSHGPFYTFLFLYLENLGAS 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 527037313  263 TRAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIG-SSFATTAVEVIALKMLHAL 329
Cdd:pfam12832 235 NTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLyAFFVENPWLVLPIQFLHAI 302
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
226-403 2.55e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.93  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 226 RMWMFILYVIGVACVYDVFDQQFATFFKTFFSTPQEGTrafGFATTAGEICNAIIMFCSPWIINRIGA--KNTLLIAGLI 303
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA---GLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 304 MATRIIGSSFATTAVEVIALKMLHALEVPFLLVGAFKYITGVFDTRLSATIylIGFQ-FAKQSAAIFLSAFAGNMYDRIG 382
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTA--SGLVnTFGFLGGALGPLLVGYLLDATG 335

                        170       180
                 ....*....|....*....|.
gi 527037313 383 FQETYLMLGCFVLAITVVSAF 403
Cdd:COG2271  336 YQAAFLLLAALALLAALLALL 356
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
34-305 3.40e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 3.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  34 FLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLK--KHLLWIITVLLFLFAPFFLYVFAPLLKSS---I 108
Cdd:COG2211   32 YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAIPLALSFVLLFTAPDLSPTgklI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 109 WLGALSGGLYIGF-VFSAGSGAI-----EAYIERVSRNSVfeygkARMFGCLGWGLCASTGGILFGIDPS-------YVF 175
Cdd:COG2211  112 YALVTYLLLGLAYtLVNIPYSALgaeltPDYEERTRLSSW-----RFAFAGLGGLLASVLPPPLVAAFGGdaalgyrLTA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 176 WMGSAAALLLMLLLVVAKPKPNQTAQvmnalganQPQITARTVFNLFRQRRMWMFILYVIGVACVYDVFDQQFATFFKTF 255
Cdd:COG2211  187 LIFAVLGLLAFLLTFFGTKERPVPEE--------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYV 258

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 527037313 256 FSTPQEgtrAFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMA 305
Cdd:COG2211  259 LGLSAA---LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
11-134 4.86e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.88  E-value: 4.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLF 90
Cdd:COG2814  206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 527037313  91 lfapfflyVFAPLLKSSIWLGALSGGLYIGFVFSAGSGAIEAYI 134
Cdd:COG2814  286 --------GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
 32-82 9.19e-04

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 41.19  E-value: 9.19e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 527037313  32 FPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLL 82
Cdd:cd17366  213 LSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYA 263
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
11-134 2.41e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.86  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVllf 90
Cdd:COG2223  204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAL--- 280

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 527037313  91 lfaPFFLYVFAPLLKSSIWLgALSGGLYIGFVFSAGSGAIEAYI 134
Cdd:COG2223  281 ---MALGLLLLALALGSLWL-FLVLFLLLGLALGGGNGAVFALV 320
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
265-415 3.05e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 265 AFGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALEVPFLLVGAFKYITG 344
Cdd:COG2814   46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIAD 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527037313 345 VFDTRLSATIylIGFQFAKQSAAIFLSAF-AGNMYDRIGFQETYLMLGCFVLAITVVSAFTLSSKQEIAARR 415
Cdd:COG2814  126 LVPPERRGRA--LGLLGAGLGLGPALGPLlGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR 195
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
225-401 3.51e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.47  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 225 RRMWMFILYVIGVACVYDVFDQQFATFFKTFFSTPQEGTRA-FGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLI 303
Cdd:COG2271    5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAqLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 304 MATRIIGSSFATTAVEVIALKMLHALEVPFLLVGAFKYITGVFDTRLSATIYLIgFQFAKQSAAIFLSAFAGNMYDRIGF 383
Cdd:COG2271   85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGI-FNAGGPLGGALAPPLLGWLLAAFGW 163

                        170
                 ....*....|....*...
gi 527037313 384 QETYLMLGCFVLAITVVS 401
Cdd:COG2271  164 RAAFLILGLPGLLLALLR 181
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 27-403 5.70e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 5.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313  27 IMATC--FPFLPIWLSDVIGLNKTHTGIVFSCISLSAIAFQPVLGVISDKLGLKKHLLWIITVLLFLFapfflyvFAPLL 104
Cdd:cd17473   12 VMAGAaiAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGG-------VAGLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 105 KSSIWLGALSG---GLYIGFVFSAGSGAIEAYIERVSRNSVFeyGKARMFGCLGWGLCASTGGILFGIDPSYVFWMGSAA 181
Cdd:cd17473   85 LDSLYALLASRallGIGVAGIMTLATALIGDYFEGEERAKML--GLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 182 ALLLMLLLVVAkPKPNQTAQVMNALGANQPQItartvfnlFRQRRMWMFILYVIGVACVYDVFDQQFATFFKTFFSTPQE 261
Cdd:cd17473  163 LPVLILVLLFL-PEPARKSKSAASPGAATAAA--------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527037313 262 GTrafGFATTAGEICNAIIMFCSPWIINRIGAKNTLLIAGLIMATRIIGSSFATTAVEVIALKMLHALEVPFLLVGAFKY 341
Cdd:cd17473  234 LI---GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW 310

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 527037313 342 ITGVFDTRLS--ATIYLIGFQFAKQSAAIFLSAFAGNMYDriGFQETYLMLGCFVLAITVVSAF 403
Cdd:cd17473  311 AMSLVPPELRgrAMGIVTSAFFLGQFLSPLVLGPLVNLTG--GLSGAFLILGVLALVLAIVLLL 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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