|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
53-472 |
1.22e-150 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 436.92 E-value: 1.22e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 53 VWSVEEHGIDPKLLSRNAVKVTSTLQEAGYDAFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFRRSRIIGRRFQIVH 132
Cdd:TIGR01942 1 VIPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 133 VTFygGREqeIIEVSTFRAlvdaveseqvpagkrvkrteldHHTHAVDASGRVLRDNVWGTQAEDATRRDFTVNAMYYNP 212
Cdd:TIGR01942 81 VSF--GRQ--IIEVATFRS----------------------GHKSSVNAEGRILKDNVYGTLEEDAWRRDFTVNALYYDP 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 213 ADQTVHDYHRGMEDMRARLLRMIGDPHTRYREDPVRMLRVVRFAAKTGFDIDPATRAPIAELGPLIHNVPAARLFDEMLK 292
Cdd:TIGR01942 135 SREVIIDYVGGMEDLKNRRLRLIGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 293 LLMSGHAWASLQELRKAGLHRGLLPLLDVAL-EQP--MGQRFVQLALDNTDERVKAGKPVSPGFLFASLMWHHVLEHWNR 369
Cdd:TIGR01942 215 LLFSGRSAALFRMLCGYQLLEPLFPSVAYALrESPkfESAFTVQALVNDTDFRVKRDKPVTPAFLYAALLWPGLVFRVAD 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 370 RRAAGEPLIPALHEAMDEVLDRQTEQLAIQRRFTADMKEIWSMQPRFEKRVGRMPHRLLESPRFRAGYDFLVLRCASGEL 449
Cdd:TIGR01942 295 APDQGVMPYPAVFDAIRDFVEEQCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRE 374
|
410 420
....*....|....*....|...
gi 525966808 450 PQELAAWWTDFQNGDGEAREALI 472
Cdd:TIGR01942 375 NAVLGEWWTPYQLASEEERTEMT 397
|
|
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
57-461 |
3.46e-132 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 392.19 E-value: 3.46e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 57 EEHGIDPKLLSRNAVKVTSTLQEAGYDAFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFRRSRIIGRRFQIVHVTFy 136
Cdd:PRK11623 42 EQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMF- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 137 ggrEQEIIEVSTFRALVDAVESeqvpagkrvkrtelDHHTHAVDASGRVLRDNVWGTQAEDATRRDFTVNAMYYNPADQT 216
Cdd:PRK11623 121 ---GPEIIEVATFRGHHEGNES--------------DRNTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 217 VHDYHRGMEDMRARLLRMIGDPHTRYREDPVRMLRVVRFAAKTGFDIDPATRAPIAELGPLIHNVPAARLFDEMLKLLMS 296
Cdd:PRK11623 184 VRDYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 297 GHAWASLQELRKAGLHRGLLPLLDVAL----EQPMgQRFVQLALDNTDERVKAGKPVSPGFLFASLMWHHVLEHWNR-RR 371
Cdd:PRK11623 264 GYGYETYKLLCEYHLFQPLFPTITRYFtengDSPM-ERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQKiAQ 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 372 AAGEPLIPALHEAMDEVLDRQTEQLAIQRRFTADMKEIWSMQPRFEKRVGRMPHRLLESPRFRAGYDFLVLRCA---SGE 448
Cdd:PRK11623 343 ESGLAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEvenNAE 422
|
410
....*....|...
gi 525966808 449 LpQELAAWWTDFQ 461
Cdd:PRK11623 423 L-QRLAQWWGEFQ 434
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
66-461 |
5.94e-112 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 337.17 E-value: 5.94e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 66 LSRNAVKVTSTLQEAGYDAFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFR---RSRIIGRRFQIVHVTFyggrEQE 142
Cdd:COG0617 2 LSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVF----GGE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 143 IIEVSTFRalvdaveseqvpagkrvkrteldhhTHAVDASGRvLRDNVWG-TQAEDATRRDFTVNAMYYNPADQTVHDYH 221
Cdd:COG0617 78 KIEVATAR-------------------------TERYYGDGR-RPFVEFGdTLEEDLARRDFTINALAYDLNDGELIDPF 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 222 RGMEDMRARLLRMIGDPHTRYREDPVRMLRVVRFAAKTGFDIDPATRAPIAELGPLIHNVPAARLFDEMLKLLMSGHAWA 301
Cdd:COG0617 132 GGLADLEARVIRTVGDPEERFREDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 302 SLQELRKAGLHRGLLplldvaleqpmgqrfvqlaldntdervkagkpvspgFLFASLMwHHVLEHWNrrRAAGEPLIPAL 381
Cdd:COG0617 212 GLELLRETGLLEVLA------------------------------------LRLAALL-HDLGKPAT--REDGLPTFHGH 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 382 HEAMDEVLDRQTEQLAIQRRFTADMKEIWSMQPRFEKRVGRMP---HRLLEsPRFRAGYDFLVLRCASGELP---QELAA 455
Cdd:COG0617 253 EEAGAELAEALLKRLRLPNRERKLVRELVELHLRFHGLGELRDsavRRLLE-RGPEALEDLLLLRENGLEYPelqERLAE 331
|
410
....*....|
gi 525966808 456 W----WTDFQ 461
Cdd:COG0617 332 LleaaWRRFQ 341
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
373-472 |
1.16e-49 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 166.22 E-value: 1.16e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 373 AGEPLIPALHEAMDEVLDRQTEQLAIQRRFTADMKEIWSMQPRFEKRVGRMPHRLLESPRFRAGYDFLVLRCASGELPQE 452
Cdd:pfam12626 1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGEVLQE 80
|
90 100
....*....|....*....|
gi 525966808 453 LAAWWTDFQNGDGEAREALI 472
Cdd:pfam12626 81 LAEWWTRFQEADEAEREAMI 100
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
69-229 |
1.07e-35 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 129.64 E-value: 1.07e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 69 NAVKVTSTLQEA-GYDAFIVGGAVRDLLLGIKPKDFDVATNA-TPEQVEALFRRSRI----IGRRFQIVHVTFYGgreqE 142
Cdd:cd05398 3 ELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKKIGGrvvgLGEEFGTATVVING----L 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 143 IIEVSTFRalvdaveseqvpagkrvkrteldhhTHAVDASGRVLRDNVWGTqAEDATRRDFTVNAMYYNPADQTVHDYHR 222
Cdd:cd05398 79 TIDVATLR-------------------------TETYTDPGRRPPVVGFTI-EEDLLRRDFTINAMAYDLDDGELIDPFG 132
|
....*..
gi 525966808 223 GMEDMRA 229
Cdd:cd05398 133 GLKDLEN 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
53-472 |
1.22e-150 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 436.92 E-value: 1.22e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 53 VWSVEEHGIDPKLLSRNAVKVTSTLQEAGYDAFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFRRSRIIGRRFQIVH 132
Cdd:TIGR01942 1 VIPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 133 VTFygGREqeIIEVSTFRAlvdaveseqvpagkrvkrteldHHTHAVDASGRVLRDNVWGTQAEDATRRDFTVNAMYYNP 212
Cdd:TIGR01942 81 VSF--GRQ--IIEVATFRS----------------------GHKSSVNAEGRILKDNVYGTLEEDAWRRDFTVNALYYDP 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 213 ADQTVHDYHRGMEDMRARLLRMIGDPHTRYREDPVRMLRVVRFAAKTGFDIDPATRAPIAELGPLIHNVPAARLFDEMLK 292
Cdd:TIGR01942 135 SREVIIDYVGGMEDLKNRRLRLIGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 293 LLMSGHAWASLQELRKAGLHRGLLPLLDVAL-EQP--MGQRFVQLALDNTDERVKAGKPVSPGFLFASLMWHHVLEHWNR 369
Cdd:TIGR01942 215 LLFSGRSAALFRMLCGYQLLEPLFPSVAYALrESPkfESAFTVQALVNDTDFRVKRDKPVTPAFLYAALLWPGLVFRVAD 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 370 RRAAGEPLIPALHEAMDEVLDRQTEQLAIQRRFTADMKEIWSMQPRFEKRVGRMPHRLLESPRFRAGYDFLVLRCASGEL 449
Cdd:TIGR01942 295 APDQGVMPYPAVFDAIRDFVEEQCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRE 374
|
410 420
....*....|....*....|...
gi 525966808 450 PQELAAWWTDFQNGDGEAREALI 472
Cdd:TIGR01942 375 NAVLGEWWTPYQLASEEERTEMT 397
|
|
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
57-461 |
3.46e-132 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 392.19 E-value: 3.46e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 57 EEHGIDPKLLSRNAVKVTSTLQEAGYDAFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFRRSRIIGRRFQIVHVTFy 136
Cdd:PRK11623 42 EQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMF- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 137 ggrEQEIIEVSTFRALVDAVESeqvpagkrvkrtelDHHTHAVDASGRVLRDNVWGTQAEDATRRDFTVNAMYYNPADQT 216
Cdd:PRK11623 121 ---GPEIIEVATFRGHHEGNES--------------DRNTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 217 VHDYHRGMEDMRARLLRMIGDPHTRYREDPVRMLRVVRFAAKTGFDIDPATRAPIAELGPLIHNVPAARLFDEMLKLLMS 296
Cdd:PRK11623 184 VRDYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 297 GHAWASLQELRKAGLHRGLLPLLDVAL----EQPMgQRFVQLALDNTDERVKAGKPVSPGFLFASLMWHHVLEHWNR-RR 371
Cdd:PRK11623 264 GYGYETYKLLCEYHLFQPLFPTITRYFtengDSPM-ERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQKiAQ 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 372 AAGEPLIPALHEAMDEVLDRQTEQLAIQRRFTADMKEIWSMQPRFEKRVGRMPHRLLESPRFRAGYDFLVLRCA---SGE 448
Cdd:PRK11623 343 ESGLAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEvenNAE 422
|
410
....*....|...
gi 525966808 449 LpQELAAWWTDFQ 461
Cdd:PRK11623 423 L-QRLAQWWGEFQ 434
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
66-461 |
5.94e-112 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 337.17 E-value: 5.94e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 66 LSRNAVKVTSTLQEAGYDAFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFR---RSRIIGRRFQIVHVTFyggrEQE 142
Cdd:COG0617 2 LSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVF----GGE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 143 IIEVSTFRalvdaveseqvpagkrvkrteldhhTHAVDASGRvLRDNVWG-TQAEDATRRDFTVNAMYYNPADQTVHDYH 221
Cdd:COG0617 78 KIEVATAR-------------------------TERYYGDGR-RPFVEFGdTLEEDLARRDFTINALAYDLNDGELIDPF 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 222 RGMEDMRARLLRMIGDPHTRYREDPVRMLRVVRFAAKTGFDIDPATRAPIAELGPLIHNVPAARLFDEMLKLLMSGHAWA 301
Cdd:COG0617 132 GGLADLEARVIRTVGDPEERFREDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 302 SLQELRKAGLHRGLLplldvaleqpmgqrfvqlaldntdervkagkpvspgFLFASLMwHHVLEHWNrrRAAGEPLIPAL 381
Cdd:COG0617 212 GLELLRETGLLEVLA------------------------------------LRLAALL-HDLGKPAT--REDGLPTFHGH 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 382 HEAMDEVLDRQTEQLAIQRRFTADMKEIWSMQPRFEKRVGRMP---HRLLEsPRFRAGYDFLVLRCASGELP---QELAA 455
Cdd:COG0617 253 EEAGAELAEALLKRLRLPNRERKLVRELVELHLRFHGLGELRDsavRRLLE-RGPEALEDLLLLRENGLEYPelqERLAE 331
|
410
....*....|
gi 525966808 456 W----WTDFQ 461
Cdd:COG0617 332 LleaaWRRFQ 341
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
373-472 |
1.16e-49 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 166.22 E-value: 1.16e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 373 AGEPLIPALHEAMDEVLDRQTEQLAIQRRFTADMKEIWSMQPRFEKRVGRMPHRLLESPRFRAGYDFLVLRCASGELPQE 452
Cdd:pfam12626 1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGEVLQE 80
|
90 100
....*....|....*....|
gi 525966808 453 LAAWWTDFQNGDGEAREALI 472
Cdd:pfam12626 81 LAEWWTRFQEADEAEREAMI 100
|
|
| PRK13299 |
PRK13299 |
tRNA CCA-pyrophosphorylase; Provisional |
70-311 |
8.03e-49 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237339 [Multi-domain] Cd Length: 394 Bit Score: 173.10 E-value: 8.03e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 70 AVKVTSTLQEAGYDAFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFRRSRIIGRRFQIVHVTFyggrEQEIIEVSTF 149
Cdd:PRK13299 9 ALPILEKIKEAGFEAYFVGGSVRDYLLGRPIHDVDIATSAYPEEVKAIFPRTVDVGIEHGTVLVLE----NGEEYEVTTF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 150 RAlvdavESEQVpagkrvkrtelDHHTHAVDASGRVLRdnvwgtqaEDATRRDFTVNAMYYNpADQTVHDYHRGMEDMRA 229
Cdd:PRK13299 85 RT-----ESEYV-----------DYRRPSEVTFVRSLE--------EDLKRRDFTINAIAMD-ENGEIIDLFDGLEDLKN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 230 RLLRMIGDPHTRYREDPVRMLRVVRFAAKTGFDIDPATRAPIAELGPLIHNVPAARLFDEMLKLLMSGHAWASLQELRKA 309
Cdd:PRK13299 140 RLIRAVGNAEERFQEDALRMMRAVRFASQLGFDLETETFEAMKTQAPLLEKISVERIFVEFEKLLLGPFWRKGLKLLIET 219
|
..
gi 525966808 310 GL 311
Cdd:PRK13299 220 GL 221
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
84-233 |
3.81e-37 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 133.17 E-value: 3.81e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 84 AFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFRRSRII----GRRFQIVHVTFyggrEQEIIEVSTFRAlvDAVESE 159
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVhllsGIEFGTIHVIF----GNQILEVATFRI--EFDESD 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 525966808 160 QVpAGKRVKRTeldhhthavdasgrvlrdnvwGTQAEDATRRDFTVNAMYYNPADQTVHDYHRGMEDMRARLLR 233
Cdd:pfam01743 75 FR-NPRSEEYT---------------------GTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
69-229 |
1.07e-35 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 129.64 E-value: 1.07e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 69 NAVKVTSTLQEA-GYDAFIVGGAVRDLLLGIKPKDFDVATNA-TPEQVEALFRRSRI----IGRRFQIVHVTFYGgreqE 142
Cdd:cd05398 3 ELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKKIGGrvvgLGEEFGTATVVING----L 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 143 IIEVSTFRalvdaveseqvpagkrvkrteldhhTHAVDASGRVLRDNVWGTqAEDATRRDFTVNAMYYNPADQTVHDYHR 222
Cdd:cd05398 79 TIDVATLR-------------------------TETYTDPGRRPPVVGFTI-EEDLLRRDFTINAMAYDLDDGELIDPFG 132
|
....*..
gi 525966808 223 GMEDMRA 229
Cdd:cd05398 133 GLKDLEN 139
|
|
| tRNA_CCA_actino |
TIGR02692 |
tRNA adenylyltransferase; The enzyme tRNA adenylyltransferase, also called ... |
66-317 |
1.61e-32 |
|
tRNA adenylyltransferase; The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 131739 [Multi-domain] Cd Length: 466 Bit Score: 129.46 E-value: 1.61e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 66 LSRNAVKVTSTLQEAGYDAFIVGGAVRDLLLGIKPKDFDVATNATPEQVEALFRRSR----IIGRRFQIVHVTFYGgreq 141
Cdd:TIGR02692 12 LSPLLAPLAAAFAAAGHELYLVGGSVRDALLGRLGHDLDFTTDARPEETLAILRPWAdavwDTGIAFGTVGAEKDG---- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 142 EIIEVSTFRAlvdaveseqvpagkrvkrteldhhtHAVDASGRVLRDNVWGTQAEDATRRDFTVNAMYYN-PAD--QTVH 218
Cdd:TIGR02692 88 QQIEITTFRS-------------------------DSYDGTSRKPEVTFGDTLEGDLIRRDFTVNAMAVRiPADgsLEFH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 219 DYHRGMEDMRARLLRMIGDPHTRYREDPVRMLRVVRFAAKTGFDIDPATRAPIAELGPLIHNVPAARLFDEMLKLLMSGH 298
Cdd:TIGR02692 143 DPVGGLDDLLAKVLDTPATPEQSFGDDPLRMLRAARFVSQLGFEVAPRVRAAMTEMADQIERISAERVRVELDKLLLGDH 222
|
250
....*....|....*....
gi 525966808 299 AWASLQELRKAGLHRGLLP 317
Cdd:TIGR02692 223 PRAGIDLMVETGLADRVLP 241
|
|
| PolyA_pol_RNAbd |
pfam12627 |
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA ... |
260-323 |
3.50e-22 |
|
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA and SrmB binding motifs on polymerase A.
Pssm-ID: 463648 [Multi-domain] Cd Length: 64 Bit Score: 89.85 E-value: 3.50e-22
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 525966808 260 GFDIDPATRAPIAELGPLIHNVPAARLFDEMLKLLMSGHAWASLQELRKAGLHRGLLPLLDVAL 323
Cdd:pfam12627 1 GFTIEPETREAIRKLAPLLKKISPERIFEELLKLLLSGHPERGLELLRETGLLEYLFPELAAAL 64
|
|
| cca |
PRK10885 |
multifunctional CCA addition/repair protein; |
87-320 |
6.88e-20 |
|
multifunctional CCA addition/repair protein;
Pssm-ID: 182810 [Multi-domain] Cd Length: 409 Bit Score: 91.84 E-value: 6.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 87 VGGAVRDLLLGIKPKDFD-VATNATPEQVEAL-FRRsriIGRRFQIvhvtFYGGREQEiievstfralvdavesEQVPAg 164
Cdd:PRK10885 6 VGGAVRDALLGLPVKDRDwVVVGATPEEMLAQgYQQ---VGKDFPV----FLHPKTHE----------------EYALA- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 165 krvkRTE----LDHHTHAVDASGRVlrdnvwgTQAEDATRRDFTVNAMYYNpADQTVHDYHRGMEDMRARLLRMIGDPht 240
Cdd:PRK10885 62 ----RTErksgRGYTGFTCYAAPDV-------TLEEDLIRRDLTINAMAQD-DDGELIDPYGGQRDLEARLLRHVSPA-- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 241 rYREDPVRMLRVVRFAAK---TGFDIDPATRA---PIAELGPLIHNVPaARLFDEMLKLLMSGHAWASLQELRKAGLHRG 314
Cdd:PRK10885 128 -FAEDPLRVLRVARFAARfahLGFRIAPETLAlmrEMVASGELDALTP-ERVWKETERALMERNPQVFFQVLRDCGALAV 205
|
....*.
gi 525966808 315 LLPLLD 320
Cdd:PRK10885 206 LLPEID 211
|
|
| PRK13297 |
PRK13297 |
tRNA CCA-pyrophosphorylase; Provisional |
80-319 |
5.15e-16 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 139469 [Multi-domain] Cd Length: 364 Bit Score: 79.65 E-value: 5.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 80 AGYDAFIVGGAVRDLLLGIKPKDFD-VATNATPEQVEalfRRSRI-IGRRFQIvhvtFYGGREQEIIEVStfralvdave 157
Cdd:PRK13297 10 AGLQVYIVGGAVRDALLGLPAGDRDwVVVGATPEDMA---RRGFIpVGGDFPV----FLHPRTKEEYALA---------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 158 seqvpagkrvkRTEldhhthavDASGRVLRDNVWGTQA-----EDATRRDFTVNAMYYNPADQTVhDYHRGMEDMRARLL 232
Cdd:PRK13297 73 -----------RTE--------RKSGRGYKGFTFYTGAdvtleQDLQRRDLTVNAIARTPQGELV-DPLDGVADVRARVL 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 233 RMIGDPhtrYREDPVRMLRVVRFAAKTG-FDIDPATRA---PIAELGPLIHNVPaARLFDEMLKLLMSGHAWASLQELRK 308
Cdd:PRK13297 133 RHVGEA---FAEDPVRILRLGRFAARFGdFSIAPETMQlcrRMVEAGEADALVP-ERVWKEVSRGLMAQAPSRMLDVLAR 208
|
250
....*....|.
gi 525966808 309 AGLHRGLLPLL 319
Cdd:PRK13297 209 AGALARVMPEL 219
|
|
| PRK13296 |
PRK13296 |
CCA tRNA nucleotidyltransferase; |
85-294 |
4.85e-13 |
|
CCA tRNA nucleotidyltransferase;
Pssm-ID: 106256 [Multi-domain] Cd Length: 360 Bit Score: 70.40 E-value: 4.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 85 FIVGGAVRDLLLGIKPKDFD-VATNATPEQvealfrrsrIIGRRFQIVhvtfyggreqeiieVSTFRALVDAVESEQVPA 163
Cdd:PRK13296 4 YLVGGAVRDMLLGITPKDKDwVVVGATEDE---------MLANGFIKI--------------AANFPVFIHPQTKQEYAL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 164 GKRVKRTELDHHTHAVDASGRVlrdnvwgTQAEDATRRDFTVNAMYYNPADQTVhDYHRGMEDMRARLLRmigdpHTR-- 241
Cdd:PRK13296 61 ARSEKKTASGYHGFEVNFSKYI-------TLEDDLKRRDLTINSIAIDQNNKVI-DPFNGQADLQNRILR-----HTSia 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 525966808 242 YREDPVRMLRVVRFAAKTG---FDIDPATRAPIAEL---GPLIHnVPAARLFDEMLKLL 294
Cdd:PRK13296 128 FIEDPLRVVRLARFKAQLSnfnFSIAQEMLALIKELvktGELNH-LTRERLHIEFVKAL 185
|
|
| PRK13298 |
PRK13298 |
tRNA CCA-pyrophosphorylase; Provisional |
85-267 |
5.46e-13 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237338 [Multi-domain] Cd Length: 417 Bit Score: 70.53 E-value: 5.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 85 FIVGGAVRDLLLGIKPKDFD-VATNATPEqvEALFRRSRIIGRRFQI-VHVtfyggreqeiievstfralvdavESEQVP 162
Cdd:PRK13298 4 YLVGGAVRDSLLNLPVKDKDwVVVGGTPK--ILLSINFQQVGKDFPVfLHP-----------------------ETHEEY 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525966808 163 AGKRVKRTELDHHT-HAVDASGRVlrdnvwgTQAEDATRRDFTVNAMYYNPADQTVHDYHrGMEDMRARLLRMIGDPhtr 241
Cdd:PRK13298 59 ALARTERKSGVGYTgFITDTSSDV-------TLEEDLIRRDLTINAIAQDENGNYIDPFQ-GKKDIQLRLLRHVSES--- 127
|
170 180
....*....|....*....|....*....
gi 525966808 242 YREDPVRMLRVVRFAAK---TGFDIDPAT 267
Cdd:PRK13298 128 FIEDPLRVLRVARFAALlvhLGFKIAKET 156
|
|
| PHA01806 |
PHA01806 |
hypothetical protein |
84-117 |
3.17e-03 |
|
hypothetical protein
Pssm-ID: 222838 Cd Length: 200 Bit Score: 39.09 E-value: 3.17e-03
10 20 30
....*....|....*....|....*....|....*
gi 525966808 84 AFIVGGAVRDLLLGIKPKDFDVATNA-TPEQVEAL 117
Cdd:PHA01806 38 VALAGGAARDLMHGAEPKDIDIALYGmDDRQAELL 72
|
|
| |
