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Conserved domains on  [gi|52426787|ref|NP_002535|]
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oligodendrocyte-myelin glycoprotein precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-226 5.01e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 5.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  37 RHVDCSGRNLSTLPSGLQE--NIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAhlprSLWNMSaannnikll 114
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE----ELGNLT--------- 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 115 dksdtayqwNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMP--SKLHIVDLSNNSLTQIlpGTLINLTN 192
Cdd:COG4886 183 ---------NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDL--PELGNLTN 251

                       170       180       190
                ....*....|....*....|....*....|....
gi 52426787 193 LTHLYLHNNKFTFIPDQSfdQLFQLQEITLYNNR 226
Cdd:COG4886 252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-226 5.01e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 5.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  37 RHVDCSGRNLSTLPSGLQE--NIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAhlprSLWNMSaannnikll 114
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE----ELGNLT--------- 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 115 dksdtayqwNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMP--SKLHIVDLSNNSLTQIlpGTLINLTN 192
Cdd:COG4886 183 ---------NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDL--PELGNLTN 251

                       170       180       190
                ....*....|....*....|....*....|....
gi 52426787 193 LTHLYLHNNKFTFIPDQSfdQLFQLQEITLYNNR 226
Cdd:COG4886 252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
45-219 8.70e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 8.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   45 NLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQytNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLdkSDTAYQwN 124
Cdd:PRK15370 210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLPSALQSLDLFHNKISCL--PENLPE-E 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  125 LKYLDVSKNMLE-----------KVVLIKNTLR--------SLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLTqILPG 185
Cdd:PRK15370 285 LRYLSVYDNSIRtlpahlpsgitHLNVQSNSLTalpetlppGLKTLEAGENALTSLPASLPPELQVLDVSKNQIT-VLPE 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 52426787  186 TLInlTNLTHLYLHNNKFTFIPDQ----------SFDQLFQLQE 219
Cdd:PRK15370 364 TLP--PTITTLDVSRNALTNLPENlpaalqimqaSRNNLVRLPE 405
LRR_8 pfam13855
Leucine rich repeat;
167-226 3.01e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.01e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   167 SKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNR 226
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-59 4.83e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.77  E-value: 4.83e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 52426787     25 ICPLQCICTerHRHVDCSGRNLSTLPSGLQENIIH 59
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-225 1.96e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 1.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  56 NIIHLNLSYNHFTDLHNqLTQYTNLRTLDISNNRLESLPA--HLPRsLWNMSAANNNIKLLDKSDTAYqwNLKYLDVSKN 133
Cdd:cd21340   3 RITHLYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIENleFLTN-LTHLYLQNNQIEKIENLENLV--NLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 134 MLEKVVLIKNtLRSLEVLNLSSNKLwtvPTNMP------------SKLHIVDLSNNSLTQILPgtLINLTNLTHLYLHNN 201
Cdd:cd21340  79 RISVVEGLEN-LTNLEELHIENQRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152

                       170       180
                ....*....|....*....|....*.
gi 52426787 202 KFTFIPD--QSFDQLFQLQEITLYNN 225
Cdd:cd21340 153 QISDLEEllDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-226 5.01e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 5.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  37 RHVDCSGRNLSTLPSGLQE--NIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAhlprSLWNMSaannnikll 114
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE----ELGNLT--------- 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 115 dksdtayqwNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMP--SKLHIVDLSNNSLTQIlpGTLINLTN 192
Cdd:COG4886 183 ---------NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDL--PELGNLTN 251

                       170       180       190
                ....*....|....*....|....*....|....
gi 52426787 193 LTHLYLHNNKFTFIPDQSfdQLFQLQEITLYNNR 226
Cdd:COG4886 252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-252 3.78e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 3.78e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  37 RHVDCSGRNLSTLPSGLQE--NIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHL--PRSLWNMSAANNNIK 112
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 113 LLDKSDTAYQwNLKYLDVSKNMLEKVVLIKNtLRSLEVLNLSSNKLWTVPTNMP-SKLHIVDLSNNSLTQIlpgTLINLT 191
Cdd:COG4886 219 DLPEPLANLT-NLETLDLSNNQLTDLPELGN-LTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDL---KLKELE 293

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52426787 192 NLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGT 252
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
45-219 8.70e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 8.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   45 NLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQytNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLdkSDTAYQwN 124
Cdd:PRK15370 210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLPSALQSLDLFHNKISCL--PENLPE-E 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  125 LKYLDVSKNMLE-----------KVVLIKNTLR--------SLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLTqILPG 185
Cdd:PRK15370 285 LRYLSVYDNSIRtlpahlpsgitHLNVQSNSLTalpetlppGLKTLEAGENALTSLPASLPPELQVLDVSKNQIT-VLPE 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 52426787  186 TLInlTNLTHLYLHNNKFTFIPDQ----------SFDQLFQLQE 219
Cdd:PRK15370 364 TLP--PTITTLDVSRNALTNLPENlpaalqimqaSRNNLVRLPE 405
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-226 1.88e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.50  E-value: 1.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   36 HRHVDCSGRN----------LSTLPSGLQENIIHLNLSYNHFTDLHNQLtqYTNLRTLDISNNRLESLPAHLPRSLWNMS 105
Cdd:PRK15370 170 QRMRDCLKNNktelrlkilgLTTIPACIPEQITTLILDNNELKSLPENL--QGNIKTLYANSNQLTSIPATLPDTIQEME 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  106 AANNNI-KLLDKSDTAyqwnLKYLDVSKNMLEkvVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLTqILP 184
Cdd:PRK15370 248 LSINRItELPERLPSA----LQSLDLFHNKIS--CLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLT-ALP 320

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 52426787  185 GTLInlTNLTHLYLHNNKFTFIPdQSFDQlfQLQEITLYNNR 226
Cdd:PRK15370 321 ETLP--PGLKTLEAGENALTSLP-ASLPP--ELQVLDVSKNQ 357
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
45-187 2.02e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.50  E-value: 2.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   45 NLSTLPSGLQENIIHLNLSYNHFTDL--------------HNQLTQYTN-----LRTLDISNNRLESLPAHLPRSLWNMS 105
Cdd:PRK15370 231 QLTSIPATLPDTIQEMELSINRITELperlpsalqsldlfHNKISCLPEnlpeeLRYLSVYDNSIRTLPAHLPSGITHLN 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  106 AANN-----------NIKLLDKSDTAYQW-------NLKYLDVSKNmleKVVLIKNTL-RSLEVLNLSSNKLWTVPTNMP 166
Cdd:PRK15370 311 VQSNsltalpetlppGLKTLEAGENALTSlpaslppELQVLDVSKN---QITVLPETLpPTITTLDVSRNALTNLPENLP 387

                        170       180
                 ....*....|....*....|.
gi 52426787  167 SKLHIVDLSNNSLTQiLPGTL 187
Cdd:PRK15370 388 AALQIMQASRNNLVR-LPESL 407
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
37-167 8.93e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.58  E-value: 8.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   37 RHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQytNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDK 116
Cdd:PRK15370 286 RYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPE 363

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 52426787  117 SDTAyqwNLKYLDVSKNMLekVVLIKNTLRSLEVLNLSSNKLWTVPTNMPS 167
Cdd:PRK15370 364 TLPP---TITTLDVSRNAL--TNLPENLPAALQIMQASRNNLVRLPESLPH 409
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-226 3.39e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 3.39e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  53 LQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDKSDTAYQWNLKYLDVSK 132
Cdd:COG4886  26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 133 NM-------LEKVVLIKN----------TLRSLEVLNLSSNKLWTVPTNMPS--KLHIVDLSNNSLTQIlPGTLINLTNL 193
Cdd:COG4886 106 NEelsnltnLESLDLSGNqltdlpeelaNLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNL 184

                       170       180       190
                ....*....|....*....|....*....|...
gi 52426787 194 THLYLHNNKFTFIPDqSFDQLFQLQEITLYNNR 226
Cdd:COG4886 185 KELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216
LRR_8 pfam13855
Leucine rich repeat;
167-226 3.01e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.01e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   167 SKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNR 226
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
146-203 1.64e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.64e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52426787   146 RSLEVLNLSSNKLWTVP----TNMPSKLHIvDLSNNSLTQILPGTLINLTNLTHLYLHNNKF 203
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgafKGLSNLKVL-DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-228 1.81e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   37 RHVDCSGRNLS-TLPSGLQENIIHLNLSYNHFT-DLHNQLTQYTNLRTLDISNNrleSLPAHLPRSLWNMSAannnikll 114
Cdd:PLN00113 121 RYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGN---VLVGKIPNSLTNLTS-------- 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  115 dksdtayqwnLKYLDVSKNMLEKVVLIK-NTLRSLEVLNLSSNKL-WTVPTNMP--SKLHIVDLSNNSLTQILPGTLINL 190
Cdd:PLN00113 190 ----------LEFLTLASNQLVGQIPRElGQMKSLKWIYLGYNNLsGEIPYEIGglTSLNHLDLVYNNLTGPIPSSLGNL 259

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 52426787  191 TNLTHLYLHNNKFTF-IPDQSFDqLFQLQEITLYNNRWS 228
Cdd:PLN00113 260 KNLQYLFLYQNKLSGpIPPSIFS-LQKLISLDLSDNSLS 297
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
45-204 9.50e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.40  E-value: 9.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   45 NLSTLPSGLQEniihlnlsynhftdlhnqltqytnlrtLDISNNRLESLPAhLPRSLWNMSAANNNIKLLdksdTAYQWN 124
Cdd:PRK15387 336 SLPTLPSGLQE---------------------------LSVSDNQLASLPT-LPSELYKLWAYNNRLTSL----PALPSG 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  125 LKYLDVSKNMLEKVVLIKNTLRSLEVlnlSSNKLWTVPTnMPSKLHIVDLSNNSLTQiLPGTLINLTNLTHLYLHNNKFT 204
Cdd:PRK15387 384 LKELIVSGNRLTSLPVLPSELKELMV---SGNRLTSLPM-LPSGLLSLSVYRNQLTR-LPESLIHLSSETTVNLEGNPLS 458
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-59 4.83e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.77  E-value: 4.83e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 52426787     25 ICPLQCICTerHRHVDCSGRNLSTLPSGLQENIIH 59
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 25-53 5.97e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 45.31  E-value: 5.97e-07
                          10        20
                  ....*....|....*....|....*....
gi 52426787    25 ICPLQCICTerHRHVDCSGRNLSTLPSGL 53
Cdd:pfam01462   1 ACPVPCHCS--ATVVNCSDRGLTAVPRDL 27
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
46-207 7.32e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 51.70  E-value: 7.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   46 LSTLPSGLQENIIHLNLSYNHFTDLHNQLTQytnLRTLDISNNRLESLPAhLPRSLWNMSAANNNIKLLDK--SDTAYQW 123
Cdd:PRK15387 213 LTTLPDCLPAHITTLVIPDNNLTSLPALPPE---LRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLPAlpSGLCKLW 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  124 ----NLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLW-------TVPTnMPSKLHIVDLSNNSLTQI--LPgtlinl 190
Cdd:PRK15387 289 ifgnQLTSLPVLPPGLQELSVSDNQLASLPALPSELCKLWaynnqltSLPT-LPSGLQELSVSDNQLASLptLP------ 361

                        170
                 ....*....|....*..
gi 52426787  191 TNLTHLYLHNNKFTFIP 207
Cdd:PRK15387 362 SELYKLWAYNNRLTSLP 378
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-238 2.17e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   59 HLNLSYNHFT-DLHNQLTQYTNLRTLDISNNRLEslpAHLPRSLWNMSaannNIKLLDKSDTAYQWNLKYLDVSKNMLEK 137
Cdd:PLN00113 240 HLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLS---GPIPPSIFSLQ----KLISLDLSDNSLSGEIPELVIQLQNLEI 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  138 VVLIKN-----------TLRSLEVLNLSSNKL-WTVPTNM--PSKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKF 203
Cdd:PLN00113 313 LHLFSNnftgkipvaltSLPRLQVLQLWSNKFsGEIPKNLgkHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL 392

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 52426787  204 TFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYL 238
Cdd:PLN00113 393 EGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKL 427
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-225 1.96e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 1.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  56 NIIHLNLSYNHFTDLHNqLTQYTNLRTLDISNNRLESLPA--HLPRsLWNMSAANNNIKLLDKSDTAYqwNLKYLDVSKN 133
Cdd:cd21340   3 RITHLYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIENleFLTN-LTHLYLQNNQIEKIENLENLV--NLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 134 MLEKVVLIKNtLRSLEVLNLSSNKLwtvPTNMP------------SKLHIVDLSNNSLTQILPgtLINLTNLTHLYLHNN 201
Cdd:cd21340  79 RISVVEGLEN-LTNLEELHIENQRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152

                       170       180
                ....*....|....*....|....*.
gi 52426787 202 KFTFIPD--QSFDQLFQLQEITLYNN 225
Cdd:cd21340 153 QISDLEEllDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-201 2.37e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 2.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  45 NLSTLPsglqeNIIHLNLSYNHFTDLHNqLTQYTNLRTLDISNNRL---ESLpAHLPRSLWNMSAannniklldksdtay 121
Cdd:cd21340  63 NLENLV-----NLKKLYLGGNRISVVEG-LENLTNLEELHIENQRLppgEKL-TFDPRSLAALSN--------------- 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 122 qwNLKYLDVSKNMLEKVVLIKNtLRSLEVLNLSSNKLwtvptnmpsklhivdlsnNSLTQILpGTLINLTNLTHLYLHNN 201
Cdd:cd21340 121 --SLRVLNISGNNIDSLEPLAP-LRNLEQLDASNNQI------------------SDLEELL-DLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-235 6.39e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 6.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   62 LSYNHFT-DLHNQLTQYTNLRTLDISNN----RLESLPAHLPrSLWNMSAANNNI--KLLDKSDTAyqwNLKYLDVSKNM 134
Cdd:PLN00113 411 LQDNSFSgELPSEFTKLPLVYFLDISNNnlqgRINSRKWDMP-SLQMLSLARNKFfgGLPDSFGSK---RLENLDLSRNQ 486

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  135 LEKVvlIKNTLRSLevlnlssnklwtvptnmpSKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFT-FIPDqSFDQ 213
Cdd:PLN00113 487 FSGA--VPRKLGSL------------------SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPA-SFSE 545

                        170       180
                 ....*....|....*....|..
gi 52426787  214 LFQLQEITLYNNRWSCDHKQNI 235
Cdd:PLN00113 546 MPVLSQLDLSQNQLSGEIPKNL 567
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 174-226 1.07e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.07e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 52426787 174 LSNNSLTQIlpGTLINLTNLTHLYLHNNKFTFIpdQSFDQLFQLQEITLYNNR 226
Cdd:cd21340  31 LYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79
LRR smart00370
Leucine-rich repeats, outliers;
190-212 2.01e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 2.01e-03
                           10        20
                   ....*....|....*....|...
gi 52426787    190 LTNLTHLYLHNNKFTFIPDQSFD 212
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
190-212 2.01e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 2.01e-03
                           10        20
                   ....*....|....*....|...
gi 52426787    190 LTNLTHLYLHNNKFTFIPDQSFD 212
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_8 pfam13855
Leucine rich repeat;
78-158 2.34e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787    78 TNLRTLDISNNRLESLPAHLPRSLwnmsaannniklldksdtayqWNLKYLDVSKNMLEkvVLIKNT---LRSLEVLNLS 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGL---------------------SNLKVLDLSNNLLT--TLSPGAfsgLPSLRYLDLS 57


                  ....
gi 52426787   155 SNKL 158
Cdd:pfam13855  58 GNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-214 4.67e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 4.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  37 RHVDCSGRNLSTLPS-GLQENIIHLNLSYNHFTDLhNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLD 115
Cdd:COG4886 231 ETLDLSNNQLTDLPElGNLTNLEELDLSNNQLTDL-PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 116 KSDTAYQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLTQILPGTLINLTNLTH 195
Cdd:COG4886 310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389

                       170
                ....*....|....*....
gi 52426787 196 LYLHNNKFTFIPDQSFDQL 214
Cdd:COG4886 390 LLLLLTTTAGVLLLTLALL 408
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 79-230 5.24e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 5.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  79 NLRTLDISNNRLES---------LPAHlpRSLWNMSAANNN-----IKLLDKSDTAYQwNLKYLDVSKNML--EKVVLIK 142
Cdd:cd00116 138 ALEKLVLGRNRLEGascealakaLRAN--RDLKELNLANNGigdagIRALAEGLKANC-NLEVLDLNNNGLtdEGASALA 214

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 143 NTL---RSLEVLNLSSNKLWTVP-----TNMPS---KLHIVDLSNNSLTQILPGTLI----NLTNLTHLYLHNNKFTF-I 206
Cdd:cd00116 215 ETLaslKSLEVLNLGDNNLTDAGaaalaSALLSpniSLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGEeG 294

                       170       180
                ....*....|....*....|....
gi 52426787 207 PDQSFDQLFQLQEITLYNNRWSCD 230
Cdd:cd00116 295 AQLLAESLLEPGNELESLWVKDDS 318
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-203 7.63e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 7.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787   60 LNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLpahLPRSLWNMSaannniklldksdtayqwNLKYLDVSKNMLEKVv 139
Cdd:PLN00113 457 LSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGA---VPRKLGSLS------------------ELMQLKLSENKLSGE- 514

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52426787  140 lIKNTLRS---LEVLNLSSNKL-WTVP---TNMPSkLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKF 203
Cdd:PLN00113 515 -IPDELSSckkLVSLDLSHNQLsGQIPasfSEMPV-LSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 168-226 8.36e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 8.36e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 52426787 168 KLHIVDLSNNSLTQIlpGTLINLTNLTHLYLHNNKFTFIPDqsFDQLFQLQEITLYNNR 226
Cdd:cd21340   3 RITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQ 57
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 60-242 9.10e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.23  E-value: 9.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787  60 LNLSYNHFTD-----LHNQLTQYTNLRTLDISNNR-----LESLPAHL--PRSLWNMSAANNNI-----KLLDKSdTAYQ 122
Cdd:COG5238 213 LWLKRNPIGDegaeiLAEALKGNKSLTTLDLSNNQigdegVIALAEALknNTTVETLYLSGNQIgaegaIALAKA-LQGN 291

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 123 WNLKYLDVSKNML--EKVVLIKNTLR---SLEVLNLSSNK------------LWTVPTnmpskLHIVDLSNNSLTQI--- 182
Cdd:COG5238 292 TTLTSLDLSVNRIgdEGAIALAEGLQgnkTLHTLNLAYNGigaqgaialakaLQENTT-----LHSLDLSDNQIGDEgai 366

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52426787 183 -LPGTLINLTNLTHLYLHNNKftfIPDQSFDQLF------QLQEITLYNNRWSCDHKQNITYLL---KWM 242
Cdd:COG5238 367 aLAKYLEGNTTLRELNLGKNN---IGKQGAEALIdalqtnRLHTLILDGNLIGAEAQQRLEQLLeriKSV 433
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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