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Conserved domains on  [gi|521374622|gb|AGP70174|]
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PTS system EIIC, probable mannose specific [Lacticaseibacillus rhamnosus LOCK900]

Protein Classification

PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC( domain architecture ID 10007905)

PTS mannose/fructose/sorbose/N-acetylgalactosamine-specific transporter subunit IIC is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming sugar substrates (such as mannose, fructose, sorbose, and N-acetylgalactosamine) concomitantly with their translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
 2-282 6.61e-66

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


:

Pssm-ID: 442929  Cd Length: 259  Bit Score: 207.28  E-value: 6.61e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622   2 IAWWQIVIITLYAGYQILDELQIYSAMSSPVFAGLVAGLVMGDMKAGLLIGASTQLMVLGVGTFGGASKIDANSGTLLAT 81
Cdd:COG3715    3 ISLIQAILIGLVAFLAGIDGLLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGIIGT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622  82 AFSVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGLALAF 161
Cdd:COG3715   83 ALAILSGQDPETAIALAVPVGL-LGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGPLLQFLLRAIPVFLALYF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622 162 GGGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFIFtmlfttlfgniqtlgtavagvak 241
Cdd:COG3715  162 GADAVQALLNAIP---AWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVL----------------------- 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 521374622 242 nftATFNGLSMLAIALIGFAFAAISYQQSTQLHDSVGGGSE 282
Cdd:COG3715  216 ---AAYLKLPLLAIAIIGVAIALIYYQLKKKKNAAAAAASG 253
 
Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
 2-282 6.61e-66

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 442929  Cd Length: 259  Bit Score: 207.28  E-value: 6.61e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622   2 IAWWQIVIITLYAGYQILDELQIYSAMSSPVFAGLVAGLVMGDMKAGLLIGASTQLMVLGVGTFGGASKIDANSGTLLAT 81
Cdd:COG3715    3 ISLIQAILIGLVAFLAGIDGLLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGIIGT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622  82 AFSVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGLALAF 161
Cdd:COG3715   83 ALAILSGQDPETAIALAVPVGL-LGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGPLLQFLLRAIPVFLALYF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622 162 GGGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFIFtmlfttlfgniqtlgtavagvak 241
Cdd:COG3715  162 GADAVQALLNAIP---AWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVL----------------------- 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 521374622 242 nftATFNGLSMLAIALIGFAFAAISYQQSTQLHDSVGGGSE 282
Cdd:COG3715  216 ---AAYLKLPLLAIAIIGVAIALIYYQLKKKKNAAAAAASG 253
EII-Sor pfam03609
PTS system sorbose-specific iic component;
4-265 4.13e-59

PTS system sorbose-specific iic component;


Pssm-ID: 460987  Cd Length: 233  Bit Score: 188.77  E-value: 4.13e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622    4 WWQIVIITLYAGYQILDELQIYSAMSSPVFAGLVAGLVMGDMKAGLLIGASTQLMVLGVGTFGGASKIDANSGTLLATAF 83
Cdd:pfam03609   1 LIQAILIGLVAFLAGLDGLLGQFTLHRPLVAGTLVGLILGDVQTGLIIGATLQLMYLGVVTIGGAVPPDAALAGIIGTAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622   84 SVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIER-YFLAGALPWALSRMIPVGLALAFG 162
Cdd:pfam03609  81 AILSGIGPEAAIALAVPVAL-LGQQLDNLVRTINSFFVHKADKYAEEGNYKGIERiHLLGPQLLGLLIRFIPVFLALYFG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622  163 GGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFIFtmlfttlfgniqtlgtavagvakn 242
Cdd:pfam03609 160 ADAVQALLNAIP---EWLTNGLTVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVL------------------------ 212

                         250       260
                  ....*....|....*....|...
gi 521374622  243 ftATFNGLSMLAIALIGFAFAAI 265
Cdd:pfam03609 213 --AAYLKLPLIAIAIIGVAIALI 233
PRK15065 PRK15065
mannose/fructose/sorbose family PTS transporter subunit IIC;
7-285 8.11e-14

mannose/fructose/sorbose family PTS transporter subunit IIC;


Pssm-ID: 237895  Cd Length: 262  Bit Score: 69.87  E-value: 8.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622   7 IVIITLYAGYQ-ILDELQIYSamssPVFAGLVAGLVMGDMKAGLLIGASTQLMVLGVGTFGGASKIDANSGTlLATAFSV 85
Cdd:PRK15065  11 VFIVAFIAGMEsILDEFQFHR----PLVACTLIGLVLGDLKTGIILGGTLEMIALGWMNIGAAVAPDAALAS-VISAILV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622  86 SSGMKPEAAVAAIAVPVASIMIQTDILARFANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGL-ALAFGGG 164
Cdd:PRK15065  86 IAGHQGIGTGIAIAIPLAAAGQVLTIIVRTITVAFQHAADKAAEEGNFRAIEWLHVSALLLQALRIAIPAALvALAVGTS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622 165 FVTniaHALNTDWKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFIftmlfttlfgniqtlgtavagvaknfT 244
Cdd:PRK15065 166 AVQ---SMLNAIPEVLTGGLNIGGGMIVVVGYAMVINMMATRELMPFFYLGFV--------------------------L 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 521374622 245 ATFNGLSMLAIALIGFAFAAISYQQSTQLHDSVGGGSEANG 285
Cdd:PRK15065 217 AAFTNLNLIALGVIGVVLALIYLQLSPKYGRVAGGGAAGSG 257
 
Name Accession Description Interval E-value
ManY COG3715
Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component ...
 2-282 6.61e-66

Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 442929  Cd Length: 259  Bit Score: 207.28  E-value: 6.61e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622   2 IAWWQIVIITLYAGYQILDELQIYSAMSSPVFAGLVAGLVMGDMKAGLLIGASTQLMVLGVGTFGGASKIDANSGTLLAT 81
Cdd:COG3715    3 ISLIQAILIGLVAFLAGIDGLLGQFQLHRPLVAGLLVGLILGDVKTGLIIGATLQLIYLGVVNIGGAVPPDPALAGIIGT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622  82 AFSVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGLALAF 161
Cdd:COG3715   83 ALAILSGQDPETAIALAVPVGL-LGQVLDILVRTINSFFVHKADKYAEEGNFKGIERLHLLGPLLQFLLRAIPVFLALYF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622 162 GGGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFIFtmlfttlfgniqtlgtavagvak 241
Cdd:COG3715  162 GADAVQALLNAIP---AWLTHGLSVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVL----------------------- 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 521374622 242 nftATFNGLSMLAIALIGFAFAAISYQQSTQLHDSVGGGSE 282
Cdd:COG3715  216 ---AAYLKLPLLAIAIIGVAIALIYYQLKKKKNAAAAAASG 253
EII-Sor pfam03609
PTS system sorbose-specific iic component;
4-265 4.13e-59

PTS system sorbose-specific iic component;


Pssm-ID: 460987  Cd Length: 233  Bit Score: 188.77  E-value: 4.13e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622    4 WWQIVIITLYAGYQILDELQIYSAMSSPVFAGLVAGLVMGDMKAGLLIGASTQLMVLGVGTFGGASKIDANSGTLLATAF 83
Cdd:pfam03609   1 LIQAILIGLVAFLAGLDGLLGQFTLHRPLVAGTLVGLILGDVQTGLIIGATLQLMYLGVVTIGGAVPPDAALAGIIGTAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622   84 SVSSGMKPEAAVAAIAVPVAsIMIQTDILARFANTFFAHRIDKMVDEYNYKGIER-YFLAGALPWALSRMIPVGLALAFG 162
Cdd:pfam03609  81 AILSGIGPEAAIALAVPVAL-LGQQLDNLVRTINSFFVHKADKYAEEGNYKGIERiHLLGPQLLGLLIRFIPVFLALYFG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622  163 GGFVTNIAHALNtdwKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFIFtmlfttlfgniqtlgtavagvakn 242
Cdd:pfam03609 160 ADAVQALLNAIP---EWLTNGLTVAGGMLPAVGFAMLLKMMGKKKLWPFFFLGFVL------------------------ 212

                         250       260
                  ....*....|....*....|...
gi 521374622  243 ftATFNGLSMLAIALIGFAFAAI 265
Cdd:pfam03609 213 --AAYLKLPLIAIAIIGVAIALI 233
PRK15065 PRK15065
mannose/fructose/sorbose family PTS transporter subunit IIC;
7-285 8.11e-14

mannose/fructose/sorbose family PTS transporter subunit IIC;


Pssm-ID: 237895  Cd Length: 262  Bit Score: 69.87  E-value: 8.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622   7 IVIITLYAGYQ-ILDELQIYSamssPVFAGLVAGLVMGDMKAGLLIGASTQLMVLGVGTFGGASKIDANSGTlLATAFSV 85
Cdd:PRK15065  11 VFIVAFIAGMEsILDEFQFHR----PLVACTLIGLVLGDLKTGIILGGTLEMIALGWMNIGAAVAPDAALAS-VISAILV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622  86 SSGMKPEAAVAAIAVPVASIMIQTDILARFANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGL-ALAFGGG 164
Cdd:PRK15065  86 IAGHQGIGTGIAIAIPLAAAGQVLTIIVRTITVAFQHAADKAAEEGNFRAIEWLHVSALLLQALRIAIPAALvALAVGTS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622 165 FVTniaHALNTDWKWLGDGLATAGAVLPAVGFAILLHYLPVKKHFAYLILGFIftmlfttlfgniqtlgtavagvaknfT 244
Cdd:PRK15065 166 AVQ---SMLNAIPEVLTGGLNIGGGMIVVVGYAMVINMMATRELMPFFYLGFV--------------------------L 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 521374622 245 ATFNGLSMLAIALIGFAFAAISYQQSTQLHDSVGGGSEANG 285
Cdd:PRK15065 217 AAFTNLNLIALGVIGVVLALIYLQLSPKYGRVAGGGAAGSG 257
PRK09757 PRK09757
PTS N-acetylgalactosamine transporter subunit IIC;
31-237 3.58e-08

PTS N-acetylgalactosamine transporter subunit IIC;


Pssm-ID: 236621  Cd Length: 267  Bit Score: 53.31  E-value: 3.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622  31 PVFAGLVAGLVMGDMKAGLLIGASTQLMVLGVGTFGGASKIDANSGTLLATAFSVSSGMkpEAAVAAIAVPVASIMIQTD 110
Cdd:PRK09757  33 PIIVCTLTGAILGDIQTGLITGGLTELAFAGLTPAGGVQPPNPIMAGLMTTVIAWSTGV--DAKTAIGLGLPFSLLMQYV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521374622 111 ILARF-ANTFFAHRIDKMVDEYNYKGIERYFLAGALPWALSRMIPVGLALAFGGGFVTNIAHALNtdwKWLGDGLATAGA 189
Cdd:PRK09757 111 ILFFYsAFSLFMTKADKCAKEADTAAFSRLNWTTMLIVASAYAVIAFLCTYLAQGAMQALVKAMP---AWLTHGFEVAGG 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 521374622 190 VLPAVGFAILLHYLPVKKHFAYLILGFIFTML--FTTLFgNIQTLGTAVA 237
Cdd:PRK09757 188 ILPAVGFGLLLRVMFKAQYIPYLIAGFLFVCYiqVSNLL-PVAVLGAGFA 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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