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Conserved domains on  [gi|521063786|ref|WP_020395737|]
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acyl carrier protein [Thiolinea disciformis]

Protein Classification

acyl carrier protein( domain architecture ID 10011594)

acyl carrier protein functions as the carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Ontology:  GO:0009245|GO:0000036|GO:0000035
PubMed:  20662770

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 5.18e-35

acyl carrier protein; Provisional


:

Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 113.73  E-value: 5.18e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521063786  1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQA 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 5.18e-35

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 113.73  E-value: 5.18e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521063786  1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQA 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 1-77 7.04e-28

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 95.54  E-value: 7.04e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521063786   1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQ 77
Cdd:TIGR00517  1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-78 2.11e-22

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 81.82  E-value: 2.11e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521063786  1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQA 78
Cdd:COG0236   3 REELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-68 1.61e-11

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 53.72  E-value: 1.61e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521063786   6 SRVKAIIVEQLGVDEADVKNEASFiDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQA 68
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDL-FDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 8-56 8.65e-05

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 37.23  E-value: 8.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 521063786    8 VKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIP 56
Cdd:smart00823 17 VREQVAAVLGHAAAEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLP 65
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 1-78 5.18e-35

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 113.73  E-value: 5.18e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521063786  1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQA 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 1-77 7.04e-28

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 95.54  E-value: 7.04e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521063786   1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQ 77
Cdd:TIGR00517  1 MQEIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 2-80 3.96e-25

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 90.91  E-value: 3.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521063786   2 SDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDY-AKAAQAKA 80
Cdd:PTZ00171  69 EDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYiEQNNMAKT 148
acpP CHL00124
acyl carrier protein; Validated
 1-79 3.29e-24

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 86.61  E-value: 3.29e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521063786  1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQAK 79
Cdd:CHL00124  3 KNDIFEKVQSIVAEQLGIEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKINK 81
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-78 2.11e-22

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 81.82  E-value: 2.11e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521063786  1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQA 78
Cdd:COG0236   3 REELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKLA 80
PRK12449 PRK12449
acyl carrier protein; Provisional
 3-72 3.02e-12

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 56.25  E-value: 3.02e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521063786  3 DIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDY 72
Cdd:PRK12449  5 EIFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDY 74
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-68 1.61e-11

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 53.72  E-value: 1.61e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521063786   6 SRVKAIIVEQLGVDEADVKNEASFiDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQA 68
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDL-FDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PRK08172 PRK08172
acyl carrier protein;
3-66 6.81e-10

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 50.27  E-value: 6.81e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521063786  3 DIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTV 66
Cdd:PRK08172  4 DIEARVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMTTF 67
PRK06508 PRK06508
acyl carrier protein; Provisional
 1-59 1.72e-07

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 44.42  E-value: 1.72e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 521063786  1 MSDIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEE 59
Cdd:PRK06508  1 MSSTFDKVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLPLEQ 59
PRK05350 PRK05350
acyl carrier protein; Provisional
 3-71 2.81e-06

acyl carrier protein; Provisional


Pssm-ID: 180033  Cd Length: 82  Bit Score: 40.74  E-value: 2.81e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521063786  3 DIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAID 71
Cdd:PRK05350  6 EILERLRAILVELFEIDPEDITPEANLYEDLDLDSIDAVDLVVHLQKLTGKKIKPEEFKSVRTVQDVVD 74
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 8-56 8.65e-05

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 37.23  E-value: 8.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 521063786    8 VKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIP 56
Cdd:smart00823 17 VREQVAAVLGHAAAEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLP 65
PRK07081 PRK07081
acyl carrier protein; Provisional
 31-58 1.81e-04

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 36.09  E-value: 1.81e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 521063786 31 DDL---GADSLDTVELVMALEEEFGIEIPDE 58
Cdd:PRK07081 26 ADLyeaGLSSLATVQLMLAIEDAFDIEIPDE 56
PRK05828 PRK05828
acyl carrier protein; Validated
 3-79 8.17e-04

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 34.46  E-value: 8.17e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521063786  3 DIESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQAK 79
Cdd:PRK05828  5 EILLKIKEIAKKKNFAVTLDESNINKPYRELKIDSLDMFSIIVSLESEFNIEFSDEKLMKLKNLADLILEVKELKKQ 81
PRK05883 PRK05883
acyl carrier protein; Validated
 4-70 2.34e-03

acyl carrier protein; Validated


Pssm-ID: 180304  Cd Length: 91  Bit Score: 33.66  E-value: 2.34e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521063786  4 IESRVKAIIVEQLGVDEADVKNEASFIDDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTV---QAAI 70
Cdd:PRK05883 15 VSATLLSILRDDLNVDLTRVTPDARLVDDVGLDSVAFAVGMVAIEERLGVALSEEDLLSCDTVgdlEAAI 84
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
5-55 2.85e-03

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 34.63  E-value: 2.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 521063786    5 ESRVKAIIVEQLGVDEADVknEASFIDdLGADSLDTVELVMALEEEFGIEI 55
Cdd:PRK10252  980 ETIIAAAFSSLLGCDVVDA--DADFFA-LGGHSLLAMKLAAQLSRQFARQV 1027
PRK12316 PRK12316
peptide synthase; Provisional
 2-78 9.25e-03

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 33.01  E-value: 9.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521063786    2 SDIESRVKAIIVEQLGVDEADVkNEASFidDLGADSLDTVELVMALEEEFGIEIPDEEAEKITTVQAAIDYAKAAQA 78
Cdd:PRK12316 5071 SELEQQVAAIWAEVLQLERVGL-DDNFF--ELGGHSLLAIQVTSRIQLELGLELPLRELFQTPTLAAFVELAAAAGS 5144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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