|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
1-422 |
0e+00 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 800.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 1 MFALADVNSFYASCEKVFRPDLRDRPVIVLSNNDGCVIARSREARAIGIPMGAPWFKVKGLAEKHNVAVFSSNYSLYHSM 80
Cdd:PRK03609 1 MFALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALGIKMGDPWFKQKDLFRRCGVVCFSSNYELYADM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 81 SERVMRCLEALAPRVEQYSIDEMFLDVAGIDNCVDFEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKEW-PQF 159
Cdd:PRK03609 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqRQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 160 GGVLALTpdNPRRTEKLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNVVLERTVRELNGESCISLE 239
Cdd:PRK03609 161 GGVVDLS--NLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 240 EAPPPKQQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKEPYYGNMASESLPFPSRD 319
Cdd:PRK03609 239 EFAPTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 320 SRDIIAAAVRALGRIWVPEHRYAKAGVMLNDFTPAGVSQLSLFDDVQPRANSEALMNVVDGIN-HSGLGKVWFAGRGIAP 398
Cdd:PRK03609 319 SRDIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNaKSGKGTLYFAGQGIAQ 398
|
410 420
....*....|....*....|....
gi 520884641 399 DWQMKRDLLSPAYTTRWADIPSAR 422
Cdd:PRK03609 399 QWQMKREMLSPRYTTRWSDLLRVK 422
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
3-350 |
0e+00 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 519.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 3 ALADVNSFYASCEKVFRPDLRDRPVIVLSNNDGCVIARSREARAIGIPMGAPWFKVKGLAEKHNVAVFSSNYSLYHSMSE 82
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKALGIKMGSPYFKVPDLLERHGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 83 RVMRCLEALAPRVEQYSIDEMFLDVAGIDNCVDFEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKEWPQFGGV 162
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYGGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 163 LALTPDNPRRteKLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNVVLERTVRELNGESCISLEEAP 242
Cdd:cd01700 161 VDLTDEEVRD--KLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEYP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 243 PPKQQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKEPYYGnmASESLPFPSRDSRD 322
Cdd:cd01700 239 PPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYS--ATNTLPYPTNDTRE 316
|
330 340
....*....|....*....|....*...
gi 520884641 323 IIAAAVRALGRIWVPEHRYAKAGVMLND 350
Cdd:cd01700 317 IVKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-348 |
1.38e-127 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 371.78 E-value: 1.38e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 1 MFALADVNSFYASCEKVFRPDLRDRPVIVLS-NNDGCVIARSREARAIGIPMGAPWFKVKGLAEkhNVAVFSSNYSLYHS 79
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFGVRSGMPLFQARRLCP--DLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 80 MSERVMRCLEALAPRVEQYSIDEMFLDVAGIDNCV-DFEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKEwpq 158
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFgSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 159 fGGVLALTPDnprRTEKLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNVVLERTVRELNGESCISL 238
Cdd:COG0389 157 -DGLTVIPPG---EVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 239 EEAPPPKqQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKEpyygnmASESLPFPSR 318
Cdd:COG0389 233 EPRRPRK-SIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTT------RSRTLPEPTD 305
|
330 340 350
....*....|....*....|....*....|
gi 520884641 319 DSRDIIAAAVRALGRIWVPEHRYAKAGVML 348
Cdd:COG0389 306 DTAELLRAARELLERIYRPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
6-335 |
1.14e-57 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 192.35 E-value: 1.14e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIVLSNNDGCVIAR-SREARAIGIPMGAPWFKVKGLAEkhNVAVFSSNYSLYHSMSERV 84
Cdd:cd03586 4 DMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVSTaSYEARKFGVRSAMPIFQAKKLCP--NLIFVPPRFDKYREVSRQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 85 MRCLEALAPRVEQYSIDEMFLDVAGIDNCVDF-EDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKewPQfgGVL 163
Cdd:cd03586 82 MEILREYTPLVEPLSIDEAYLDVTDYVRLFGSaTEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNK--PN--GLT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 164 ALTPDNprrTEKLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNVVLERTVRELNGESCISLEEAPP 243
Cdd:cd03586 158 VIPPED---VEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 244 PKqQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKepyygnMASESLPFPSRDSRDI 323
Cdd:cd03586 235 RK-SIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTR------TRSRTLPEPTDDAEDI 307
|
330
....*....|..
gi 520884641 324 IAAAVRALGRIW 335
Cdd:cd03586 308 YELALELLEELL 319
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-349 |
1.81e-48 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 168.31 E-value: 1.81e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIVLSNND--GCVIARSREARAIGIPMGAPWFKVKGLAEkhNVAVFSSNYSLYHSMSER 83
Cdd:cd00424 4 DFDNFFASVEQLARPELKGRPVVVVPFNSdsTCVIACSYEARKYGVKRGMPVREARKMCP--NLILVPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 84 VMRCLEALAPRVEQYSIDEMFLDVAGIDNCVdfeDFGRQLREYVHRHTALTIG-----VGMGPSKTLAKSAQWASKEwpq 158
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLL---GLGSEVALRIKRHIAEQLGgitasIGIASNKLLAKLAAKYAKP--- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 159 fGGVLALTPDN-PRRTEKLlslqPVEEIWGVGRRISKKLNTMGITTALQLARANP-AFIRKNFNVVLERTVRELNGESCI 236
Cdd:cd00424 156 -DGLTILDPEDlPGFLSKL----PLTDLPGIGAVTAKRLEAVGINPIGDLLAASPdALLALWGGVSGERLWYALRGIDDE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 237 SLEEaPPPKQQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKT--SPFAVKEPYYGNMASESLP 314
Cdd:cd00424 231 PLSP-PRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTvdGRWSGHADIPSRSAPRPIS 309
|
330 340 350
....*....|....*....|....*....|....*
gi 520884641 315 FPSRDSRDIIAAAVRALGRIWVPEhRYAKAGVMLN 349
Cdd:cd00424 310 TEDGELLHALDKLWRALLDDKGPR-RLRRLGVRLS 343
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-383 |
2.84e-47 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 167.10 E-value: 2.84e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 4 LADVNSFYASCEKVFRPDLRDRPVIVL---SNNDGCVIARSREARAIGIPMGAPWFKVKGLAeKHNVaVFSSNYSLYHSM 80
Cdd:PRK03103 7 LVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYGVKTAERLWEAQQKC-PDLV-VVKPRMQRYIDV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 81 SERVMRCLEALAPRVEQYSIDEMFLDVAGIDNCV-DFEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSA--QWASKEwP 157
Cdd:PRK03103 85 SLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFgSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMAcdNFAKKN-P 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 158 QfgGVLALTPDNPRRteKLLSLqPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNVVLERTVRELNGescis 237
Cdd:PRK03103 164 D--GLFTLDKEDVPA--DLWPL-PVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANG----- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 238 LEEAPPPKQQIVCSRSFGERIT------EYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKEPYYGNMase 311
Cdd:PRK03103 234 IDYSPVTPHSLDRQKAIGHQMTlprdyrGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTGFSRQM--- 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 520884641 312 SLPFPSRDSRDIIAAAVRALGRIWvPEHRYAKAGVMLNDFTPAGVSQLSLFDDvqpRANSEALMNVVDGINH 383
Cdd:PRK03103 311 TLPEPTNLAMEVYEAACKLFHRHW-DGKPVRRVGVTLSNLVSDDVWQLSLFGD---RERKRSLGYVMDDIKN 378
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
6-334 |
6.58e-41 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 148.25 E-value: 6.58e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIVLSNND-----GCVIARSREARAIGIPMGAPwfkVKGLAEKHNVAVF-SSNYSLYHS 79
Cdd:PRK03352 11 DLDQFIAAVELLRRPELAGLPVIVGGNGDpteprKVVTCASYEARAFGVRAGMP---LRTAARRCPDAVFlPSDPAAYDA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 80 MSERVMRCLEALAPRVEQYSIDEMFLDVAGIDNcvdfEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKEwpqf 159
Cdd:PRK03352 88 ASEEVMATLRDLGVPVEVWGWDEAFLGVDTDDP----EALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKP---- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 160 GGVLALTPDNprrTEKLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFN-------VVLERTVrelnG 232
Cdd:PRK03352 160 AGVFRLTDAN---WMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpttgpwlLLLARGG----G 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 233 ESCISlEEAPPPKqqivcSRS----FGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFavkepyYGNM 308
Cdd:PRK03352 233 DTEVS-AEPWVPR-----SRSrevtFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATF------YTRT 300
|
330 340
....*....|....*....|....*.
gi 520884641 309 ASESLPFPSRDSRDIIAAAVRALGRI 334
Cdd:PRK03352 301 KIRKLPEPTTDPDVIEAAALDVLDRF 326
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
6-331 |
1.94e-37 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 141.23 E-value: 1.94e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIV--LSNNdGCVIARSREARAIGIPMGAPWFKVKGLAeKHNVAVFSSNYSLYHSMSER 83
Cdd:PRK03348 11 DMDAFFASVEQLTRPTLRGRPVLVggLGGR-GVVAGASYEARVFGARSAMPMHQARRLV-GNGAVVLPPRFVVYRAASRR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 84 VMRCLEALAPRVEQYSIDEMFLDVAGI--DNCVDFEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKewPQfgG 161
Cdd:PRK03348 89 VFDTLRELSPVVEQLSFDEAFVEPAELagASAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAK--PD--G 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 162 VLALTPDNPRRtekLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIrknfnvvlertVRELNGESCISL--- 238
Cdd:PRK03348 165 IRVVPPGEERE---LLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEV-----------ANLLGATVGPALhrl 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 239 ----------EEAppPKQQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKEpyygnm 308
Cdd:PRK03348 231 argiddrpvaERA--EAKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLT------ 302
|
330 340
....*....|....*....|...
gi 520884641 309 ASESLPFPSRDSRDIIAAAVRAL 331
Cdd:PRK03348 303 RSATLPYATDDAAVLAATARRLL 325
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
6-149 |
5.12e-37 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 131.93 E-value: 5.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIVLSNN-DGCVIARSREARAIGIPMGAPWFKVKGLAekHNVAVFSSNYSLYHSMSERV 84
Cdd:pfam00817 2 DMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYGVRSGMPVFEAKKLC--PNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520884641 85 MRCL-EALAPRVEQYSIDEMFLDVAGIDNCVD-FEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSA 149
Cdd:pfam00817 80 FEILrRFSTPKVEQASIDEAFLDLTGLEKLFGaEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
6-382 |
1.26e-33 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 130.15 E-value: 1.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIVLSN---NDGCVIARSREARAIGIPMGAPWFKVKGLAEkhNVAVFSSNYSLYHSMSE 82
Cdd:PRK01810 11 DMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYGIRTTMPLWEAKRLCP--QLIVRRPNFDRYREASR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 83 RVMRCLEALAPRVEQYSIDEMFLDVAGIDNCVDFEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKewPqfggv 162
Cdd:PRK01810 89 QMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKK--P----- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 163 LALTPDNPRRTEKLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNVVLERTVRELNGEscislEEAP 242
Cdd:PRK01810 162 LGITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGI-----DDRP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 243 PPKQQIVCSRSFG------ERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKepyygnMASESLPFP 316
Cdd:PRK01810 237 VDPEAIYQFKSVGnsttlsHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTI------TRSKTLKNP 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520884641 317 SRDSRDIIAAAVRALGRIW--VPEHRYAKAGVMLNDFTPAgVSQLSLFdDVQPRANSEALMNVVDGIN 382
Cdd:PRK01810 311 IWEKRDIFQAASRLFKQHWngDPVRLLGVTATDLEWKTEA-VKQLDLF-SFEEDAKEEPLLAVIDQIN 376
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
5-378 |
5.48e-31 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 122.40 E-value: 5.48e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 5 ADVNSFYASCEKVFRPDLRDRPVIVlsnNDGCVIARSREARAIGI--PMGAPwfkvKGLAEKHNVAVFSSNYSLYHSMSE 82
Cdd:PRK03858 9 ADLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYGVrtAMGGR----QARRLCPQAVVVPPRMSAYSRASK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 83 RVMRCLEALAPRVEQYSIDEMFLDVAGIDNCVDF-EDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKewPQfgG 161
Cdd:PRK03858 82 AVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTpVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAK--PD--G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 162 VLALTPDnpRRTEKLLSLqPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKnfnvVLERTV-RELngeSCISLEE 240
Cdd:PRK03858 158 LLVVPPD--RELAFLHPL-PVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVS----LLGPAAgRHL---HALAHNR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 241 APPP------KQQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKepyygnMASESLP 314
Cdd:PRK03858 228 DPRRvetgrrRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFTRA------TRSHTLP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520884641 315 FPSrDSRDIIAAAVRALGRIWVPEHR---YAKAGVMLNDFTPAGVSQLSL-FDDVQPRANSEALMNVV 378
Cdd:PRK03858 302 RPT-ASTATLLAAARDLVAAAAPLIAergLTLVGFAVSNLDDDGAQQLELpFGLRRPGSALDAALDAV 368
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
6-362 |
4.25e-29 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 116.35 E-value: 4.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIV--LSNNdGCVIARSREARAIGIPMGAPWFKVKGLAeKHNVAVfSSNYSLYHSMSER 83
Cdd:PRK14133 9 DMDAFFASVEQMDNPKLKGKPVIVggISER-GVVSTCSYEARKYGVHSAMPVFMAKKRC-PHGIFL-PVRHERYKEVSKN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 84 VMRCLEALAPRVEQYSIDEMFLDVAGIDNcvDFEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQwaskEWPQFGGVL 163
Cdd:PRK14133 86 IFKILYEVTPIVEPVSIDEAYLDITNIKE--EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDGIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 164 ALTPDnprRTEKLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNV----VLERtVRELNGESCISLE 239
Cdd:PRK14133 160 IITED---MIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKfgveIYER-IRGIDYREVEVSR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 240 EapppKQQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVkepyygNMASESLPFPSRD 319
Cdd:PRK14133 236 E----RKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQT------HTKSKTLNDYIRD 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 520884641 320 SRDIIAAAVRALGRIWVPEhrYAK-AGVMLNDFTPAGVSQLSLF 362
Cdd:PRK14133 306 KEEIYNVACEILEHINIKE--PIRlIGLSVSNLSENKIEQLSFL 347
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
245-355 |
3.73e-26 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 101.48 E-value: 3.73e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 245 KQQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKEpyygnmASESLPFPSRDSRDII 324
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTIT------RSVTLPSPTDDTDEIY 74
|
90 100 110
....*....|....*....|....*....|.
gi 520884641 325 AAAVRALGRIWvPEHRYAKAGVMLNDFTPAG 355
Cdd:pfam11799 75 RAALRLLRRLY-RGRPVRLLGVSLSNLVPEG 104
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
6-376 |
1.28e-22 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 99.24 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIVLSNNDG-----CVIARSREARAiGIPMgapwFKvkGLAEKHNVAVFSSNYSLYHSM 80
Cdd:PRK02794 42 DCDAFYASVEKRDNPELRDKPVIIGGGKRGvvstaCYIARIHGVRS-AMPM----FK--ALKLCPDAVVIKPDMEKYVRV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 81 SERVMRCLEALAPRVEQYSIDEMFLDVAGIDN------CVDFEDFGRQlreyVHRHTALTIGVGMGPSKTLAKSAQWASK 154
Cdd:PRK02794 115 GREVRAMMQALTPLVEPLSIDEAFLDLSGTERlhgappAVVLARFARR----VEREIGITVSVGLSYNKFLAKIASDLDK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 155 ewPQfgGVLALTPDNprrTEKLLSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNVVLERTVRELNGES 234
Cdd:PRK02794 191 --PR--GFSVIGRAE---ALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGID 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 235 CISLEEAPPPKqQIVCSRSFGERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSPFAVKepyygnMASESLP 314
Cdd:PRK02794 264 DRKVSPDREAK-SVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLR------TRRRTLE 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 520884641 315 FPSRDSRDIIAAAvRALGRIWVPEHRYAKAGVMLNDFTPA-GVSQLSLFDDVQPR-ANSEALMN 376
Cdd:PRK02794 337 DPTQLADRIFRTA-RELLEKETDGTAFRLIGIGVSDLSPAdEADPPDLLDPQATRrAAAERAID 399
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-201 |
3.96e-21 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 93.70 E-value: 3.96e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 1 MFALADVNSFYASCEKVFRPDLRDRPVIVL-----SNNDGCVIARSREARAIGIPMGAPWFKVKGLAEKhnvAVF-SSNY 74
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVCvysgrFEDSGAVATANYEARKLGIKAGMPIVEAKKILPN---AVYlPMRK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 75 SLYHSMSERVMRCLEALAPRVEQYSIDEMFLDVAgiDNCVDFED---FGRQLREYVHRHTALTIGVGMGPSKTLAKSAqw 151
Cdd:PRK01216 79 EVYQQVSNRIMKLLREYSEKIEIASIDEAYLDIS--DKVKNYQDaynLGLEIKNKILEKEKITVTVGISKNKVFAKIA-- 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 520884641 152 ASKEWPQFGGVLaltpdNPRRTEKLLSLQPVEEIWGVGRRISKKLNTMGI 201
Cdd:PRK01216 155 ADMAKPNGIKVI-----DDEEVKRFINELDIADIPGIGDITAEKLKKLGV 199
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
374-421 |
2.34e-19 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 80.99 E-value: 2.34e-19
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 520884641 374 LMNVVDGINHS-GLGKVWFAGRGIAPDWQMKRDLLSPAYTTRWADIPSA 421
Cdd:pfam13438 1 LMAALDAINRRyGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
10-219 |
4.77e-13 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 69.76 E-value: 4.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 10 FYASCEKVFRPDLRDRPVIVLSNND--GCVIARSREARAIGI----PMGapwfkvkgLAEK--HNVAVFSSNYSLYHSMS 81
Cdd:PRK02406 4 FYAAVEMRDNPELRGKPVAVGGSPGrrGVISTCNYEARKFGVrsamPTA--------QALKlcPDLIFVPGRFDVYKEVS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 82 ERVMRCLEALAPRVEQYSIDEMFLDVAGIDNCVdfedfG------RQLREYVHRHTALTIGVGMGPSKTLAKSAqwaSkE 155
Cdd:PRK02406 76 RQIREIFRRYTDLIEPLSLDEAYLDVTDNKLCI-----GsatliaQEIRQDIFEELGLTASAGVAPNKFLAKIA---S-D 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520884641 156 W--P--QFggVLalTPDNPrrTEKLLSLqPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNF 219
Cdd:PRK02406 147 WnkPngLF--VI--TPEEV--DAFLATL-PVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHF 207
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
3-335 |
3.09e-11 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 64.26 E-value: 3.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 3 ALADVNSFYASCEKVFRPDLRDRPVIVLSNNDgcVIARSREARAIGI-----------------PMGAPWFK----VKGL 61
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNS--IIAVSYAARAFGVtrfmtideakkkcpdliLAHVATYKkgedEADY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 62 AEKHNVAVFSSNYSLYHSMSERVMRCLEALAPRVEQYSIDEMFLDVAGIdncvdfedFGRQLREYVHRHTALTIGVGMGP 141
Cdd:cd01702 79 HENPSPARHKVSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGSR--------IVEEIRQQVYDELGYTCSAGIAH 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 142 SKTLAKSAQWASKewpqfggvlaltPDN-----PRRTEKLLSLQPVEEIWGVGRRISKKL-NTMGITTALQLA--RANPA 213
Cdd:cd01702 151 NKMLAKLASGMNK------------PNAqtilrNDAVASFLSSLPITSIRGLGGKLGEEIiDLLGLPTEGDVAgfRSSES 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 214 FIRKNFNVVLERTV-RELNGESCISLEEAPPPKqQIVCSRSFGERITEYDAMRQA-VCQYAERAAEKLRSER-QYCR--- 287
Cdd:cd01702 219 DLQEHFGEKLGEWLyNLLRGIDHEPVKPRPLPK-SMGSSKNFPGKTALSTEDVQHwLLVLASELNSRLEDDRyENNRrpk 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 520884641 288 HIAVFVKTspFAVKEPYygnmaSESLPFPSRDSRDIIAAAVRALGRIW 335
Cdd:cd01702 298 TLVLSLRQ--RGDGVRR-----SRSCALPRYDAQKIVKDAFKLIKAIN 338
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
6-372 |
2.70e-10 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 62.34 E-value: 2.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIVlsnndGCVIARSRE---ARAIGIPMGAPWFKvkGLAEKHNVAVFSSNYSLYHSMSE 82
Cdd:PTZ00205 139 DMDMFYAAVEIKKHPEYAAIPLAI-----GTMTMLQTAnyvARGRGIRQGMPGFL--ALKICPNLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 83 RVMRCLEALAPRVEQYSIDEMFLDVAG----IDNCVDFEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKEWPQ 158
Cdd:PTZ00205 212 TVRRIVAEYDPNYISFGLDELTLEVSAyierFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQ 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 159 F-------GGVLALTPDnprrteklLSLQPVEeiwGVGRRISKKLNTMGITTALQL--ARANPAFIRKN--FNVVLERTV 227
Cdd:PTZ00205 292 HdlnlhtrGDVMTYVRD--------LGLRSVP---GVGKVTEALLKGLGITTLSDIynRRVELCYILHNnlFRFLLGASI 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 228 ---------RELNGESCislEEAP-PPKQQIVCSRSFgERITEYDAMRQAVCQYAERAAEKLRSERQYCRHIAVFVKTSP 297
Cdd:PTZ00205 361 gimqwpdaaTAANTENC---EGATgGQRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWAS 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 298 FAVKEpYYGNMASESlpfpsrdsrDIIAAAVRALGRIWVPE-HRYAKA---GVMLNDFTPA--------GVSQLSLFDDV 365
Cdd:PTZ00205 437 YRYQQ-YTKSLIQYS---------DDSATLRRAVDGLLLPHaAKYSEMcllGVRFLDLISAkdfhmkrkGGNQLSISQFI 506
|
....*..
gi 520884641 366 QPRANSE 372
Cdd:PTZ00205 507 RPKKPGE 513
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-317 |
1.36e-09 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 59.41 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 6 DVNSFYASCEKVFRPDLRDRPVIVLSNNdgCVIARSREARAIGIPmgapwfKVKGLAEKHN-----VAVFSSNYSLYHSM 80
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPLGIQQKY--IVVTCNYEARRLGVK------KLMSIKDAKEicpdlVLVNGEDLTPFRDM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 81 SERVMRCLEALAP--RVEQYSIDEMFLDVAGIDNCVDfEDFGRQLREYVHRHTALTIGVGMGPSKTLAKSAQWASKEWPQ 158
Cdd:cd01703 76 SKKVYRLLRSYSWndRVERLGFDENFMDVTEMRLLVA-SHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 159 fggvLALTPDNPRRTEKLLSLQPVEEIWGVGRRISKKLNTMGITTA--LQLARANPAFIRKNFNVVLE------------ 224
Cdd:cd01703 155 ----TTLLPPSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVrdLQEFSNRNRQTVGAAPSLLElllmvkefgegi 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 225 --RTVRELNGESCISLEEAPPPKQQIVCSRSFG-----------ERITEYDAM--RQAVCQYAERAAEKLRserqycRHI 289
Cdd:cd01703 231 gqRIWKLLFGRDTSPVKPASDFPQQISIEDSYKkcsleeirearNKIEELLASllERMKQDLQEVKAGDGR------RPH 304
|
330 340
....*....|....*....|....*...
gi 520884641 290 AVFVKTSPFAVkEPYYGNMASESLPFPS 317
Cdd:cd01703 305 TLRLTLRRYTS-TKKHYNRESKQAPIPS 331
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
19-291 |
8.98e-08 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 53.54 E-value: 8.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 19 RPDLRDRPVIVLS-NNDGCVIARSREARAIGIPMGAPWFKVKGLAEkhNVAVFSSNYSLYHSMSERVMRCLEALAPRVEQ 97
Cdd:cd03468 17 RPADDEAPLAVVErKKAGRILACNAAARAAGVRPGMPLAEALALCP--NLQVVEYDPEADARALQELALWLLRFTPLVAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 98 YSIDEMFLDVAGIDNCVDFED-FGRQLREYVhrhTALTIGVGMGPSKTLAkSAQWASKewpqFGGVLALTPDNPRRTEKL 176
Cdd:cd03468 95 DGPDGLLLDVTGCLHLFGGEDaLAASLRAAL---ATLGLSARAGIADTPG-AAWLLAR----AGGGRGVLRREALAAALV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520884641 177 LSLQPVEEIWGVGRRISKKLNTMGITTALQLARANPAFIRKNFNVVLERTVRELNGE--SCISLEEAPPPKQQIVcSRSF 254
Cdd:cd03468 167 LLAPLPVAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRdpEPLLFSPPPPAFDFRL-ELQL 245
|
250 260 270
....*....|....*....|....*....|....*..
gi 520884641 255 GERITEydAMRQAVCQYAERAAEKLRSERQYCRHIAV 291
Cdd:cd03468 246 EEPIAR--GLLFPLRRLLEQLCAFLALRGLGARRLSL 280
|
|
| H3TH |
COG3743 |
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain ... |
185-217 |
2.79e-04 |
|
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain [Replication, recombination and repair];
Pssm-ID: 442957 [Multi-domain] Cd Length: 92 Bit Score: 39.53 E-value: 2.79e-04
10 20 30
....*....|....*....|....*....|...
gi 520884641 185 IWGVGRRISKKLNTMGITTALQLARANPAFIRK 217
Cdd:COG3743 28 IKGIGPKIEKKLNELGIFTFAQIAAWTPEDIAW 60
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| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
170-201 |
6.43e-04 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 36.99 E-value: 6.43e-04
10 20 30
....*....|....*....|....*....|..
gi 520884641 170 PRRTEKLLSLQPVEEIWGVGRRISKKLNTMGI 201
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| |
