|
Name |
Accession |
Description |
Interval |
E-value |
| lacY |
PRK09528 |
galactoside permease; Reviewed |
3-418 |
0e+00 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 617.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 3 PTVCTHKNNPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLM 82
Cdd:PRK09528 1 MATMYYLKNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 83 WIVTVLLVLIAPFFLYVFAPLLKTNIWLGALSGGAYIGFVFSAGAGAMEAYIERVSRNSGFEYGKARTFGCLGWALCATT 162
Cdd:PRK09528 81 WIISGLLVLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 163 AGMLFSINPEWVFWMGSAAALLLVVLVAIAKPQASQSAQVMDSLGANRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYD 242
Cdd:PRK09528 161 AGILFNINPQINFWLGSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 243 VFDQQFATFFKSFFATPEAGTRAFGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVA 322
Cdd:PRK09528 241 VFDQQFPNFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 323 LKMLHALEVPFLLVGAFKYITGVFDVRLSATIYLVGFQFAKQVAAIFLSAFAGNMYDRIGFQDTYMILGGIALTVTLISA 402
Cdd:PRK09528 321 LKLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISV 400
|
410
....*....|....*.
gi 518535583 403 FTLAGKAKTEPLRDNA 418
Cdd:PRK09528 401 FTLSGDRELSLLRRQV 416
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
11-406 |
0e+00 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 558.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVLLV 90
Cdd:TIGR00882 1 NTNFWMFGLFFFLYFFIMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 91 LIAPFFLYVFAPLLKTNIWLGALSGGAYIGFVFSAGAGAMEAYIERVSRNSGFEYGKARTFGCLGWALCATTAGMLFSIN 170
Cdd:TIGR00882 81 LFAPFFIYVFGPLLQSNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSID 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 171 PEWVFWMGSAAALLLVVLVAIAKPQASQSAQVMDSLGANRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFAT 250
Cdd:TIGR00882 161 PQIVFWLGSGFALILMLLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 251 FFKSFFATPEAGTRAFGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALE 330
Cdd:TIGR00882 241 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFE 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518535583 331 VPFLLVGAFKYITGVFDVRLSATIYLVGFQFAKQVAAIFLSAFAGNMYDRIGFQDTYMILGGIALTVTLISAFTLA 406
Cdd:TIGR00882 321 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTLS 396
|
|
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
11-408 |
0e+00 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 542.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVLLV 90
Cdd:pfam01306 6 NTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCITGLLV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 91 LIAPFFLYVFAPLLKTNIWLGALSGGAYIGFVFSAGAGAMEAYIERVSRNSGFEYGKARTFGCLGWALCATTAGMLFSIN 170
Cdd:pfam01306 86 LFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGILFSID 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 171 PEWVFWMGSAAALLLVVLVAIAKPQASQSAQVMDSLGANRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFAT 250
Cdd:pfam01306 166 PQIVFWLGSGFALILALLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFDQQFAN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 251 FFKSFFATPEAGTRAFGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALE 330
Cdd:pfam01306 246 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKMLHMFE 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518535583 331 VPFLLVGAFKYITGVFDVRLSATIYLVGFQFAKQVAAIFLSAFAGNMYDRIGFQDTYMILGGIALTVTLISAFTLAGK 408
Cdd:pfam01306 326 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTLSGS 403
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
14-405 |
8.31e-178 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 501.38 E-value: 8.31e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 14 FWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVLLVLIA 93
Cdd:cd06172 1 YWKFSLFFFLFFFIWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 94 PFFLYVFAPLLKTNIWLGALSGGAYIGFVFSAGAGAMEAYIERVSRNSGFEYGKARTFGCLGWALCATTAGMLFSINPEW 173
Cdd:cd06172 81 PFFIFVYGPLLQSNILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 174 VFWMGSAAALLLVVLVAIAKPQASQSAQVMdslGANRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFATFFK 253
Cdd:cd06172 161 NFWLGSGFALILLLLLLFAKPEDSDTAAAA---GANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 254 SFFATPEAGTRAFGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALEVPF 333
Cdd:cd06172 238 SLFATPEQGNRVFGYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPL 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518535583 334 LLVGAFKYITGVFDVRLSATIYLVGFQFAKQVAAIFLSAFAGNMYDRIGFQDTYMILGGIALTVTLISAFTL 405
Cdd:cd06172 318 LLVSIFKYITSHFDTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
27-403 |
1.84e-18 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 86.48 E-value: 1.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 27 IMATCFPFLPIWLSDvIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVLLVLIAPFFLYVFapllkT 106
Cdd:cd17335 12 ALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVA-----Q 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 107 NIWLGALSGGAYIgFVFSAGAGAMEAYIERVSRNSGFEYGKARTFGCLGWALCATTAGMLFS-----INPEWVFWMGSAA 181
Cdd:cd17335 86 IFWLLLLLVILGA-FFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDrsstyKNYTIAFYVFAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 182 ALLLVVlvaiakpqasQSAQVMDSLGANRPAIDLKTAVRMFRQRKMWMFILYV----IGVACVYdvfdqqfaTFFKSFFA 257
Cdd:cd17335 165 MLLALL----------LALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAflmgFGHGLIY--------SFLFWHLQ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 258 TPEAGTRAFGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALEVPFLLVG 337
Cdd:cd17335 227 DLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAA 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 338 AFKYITGVFDVRLSAT----IYLVGFQFAKQVAAIflsaFAGNMYDRIGFQDTYMILGGIALTVTLISAF 403
Cdd:cd17335 307 AVSYASAAAPPGLRATaqglLQGLYFGLGGGLGSL----IGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-413 |
2.73e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.09 E-value: 2.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 32 FPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKhlmWIVTVLLVLIAPFFLYVFAPLLKTNIWLG 111
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLLALAVSYWLLLLLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 112 ALsGGAYIGFVFSAGAGAMEAYIERvsRNSGFEYGKARTFGCLGWALCATTAGMLF-SINPEWVFWMGSAAALLLVVLVA 190
Cdd:COG2223 101 LL-LGIGGGGSFAVGIALVSKWFPP--DRRGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 191 IAKPQASQSAqvmdslgANRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFATFFKSFF--ATPEAGTRAFGF 268
Cdd:COG2223 178 LFLRDPPAGA-------AAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFglSAATAGLLAALF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 269 AttageICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEV-VALKMLHALEVPFLLVGAFKYITGVFD 347
Cdd:COG2223 251 A-----LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGLALGGGNGAVFALVPDIFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518535583 348 VRLSATIY-LVGfqFAKQVAAIFLSAFAGNMYDRIG-FQDTYMILGGIALTVTLISAFTLAGKAKTEP 413
Cdd:COG2223 326 TKNAGAVYgLVG--AAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-179 |
1.43e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 1 MNPTVCTHKNNPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKh 80
Cdd:cd17325 188 LRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP- 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 81 lmWIVTVLLVLIAPFFLYVFAPLLKTNIWLGALSGGAYiGFVFSAGAGAMEAYIERVSRnsGFEYGKARTFGCLGWALCA 160
Cdd:cd17325 267 --LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGL-GLVFPATLALLADIVPPEGR--GTAMGLFNTAFSLGMVLGP 341
|
170 180
....*....|....*....|
gi 518535583 161 TTAGMLF-SINPEWVFWMGS 179
Cdd:cd17325 342 LLGGFLYdAFGFATPFLAAA 361
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-395 |
1.87e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 58.98 E-value: 1.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 33 PFLPIWLSDViGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKhlmWIVTVLLVLIAPFFLYVFAPLlktniWLGA 112
Cdd:cd06174 17 PLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRP---VLLLGLLLFALGALLFAFAPS-----FWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 113 LSGGAYIGFVFSAGAGAMEAYIERVS--RNSGFEYGKARTFGCLGWALCATTAGMLFSINPE---WVFWMGSAAALLLVV 187
Cdd:cd06174 88 LLGRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALALLAAI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 188 LVAIAKPQASQSAQVMDSlgANRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFATFFKSFFATPEAgtrAFG 267
Cdd:cd06174 168 LLLLVVPDPPESARAKNE--EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA---VAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 268 FATTAGEICNAIIMFSSPWIINR-IGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALEVPFLLVGAFKYITGVF 346
Cdd:cd06174 243 LLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 518535583 347 DVRLSATIYLVGFQFAKQVAAIFLSAFAGNMYDRIGFQDTYMILGGIAL 395
Cdd:cd06174 323 PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
32-329 |
1.24e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 56.48 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 32 FPFLPIWLSDvIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKhlmWIVTVLLVLIAPFFLYVFAPLLKTNIWLG 111
Cdd:pfam12832 19 LPYWGLYLRS-IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRK---AVVRLASILAAVLFLSVLFIPISLTFWWL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 112 ALSGGAYIGFVFSAGAGAMEAYIERVSRNSGfEYGKARTFGCLGWALCATTAGMLFS-INPEWVFWMGSAAALLLVVLva 190
Cdd:pfam12832 95 ALLVVLFSFFWNAILPQFEVATLQHLGEKRK-DYGRQRLWGSVGFALSVFGLGALFDhYSVGLLPSVLFYLFAALMLL-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 191 iakpqASQSAQVMDSLGANRPAIDLKTAVRMFRQRKMWMFILyvigVACVYDVFDQQFATFFKSFFATPEAGTRAFGFAT 270
Cdd:pfam12832 172 -----SLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFL----AAFLLGFSHGPFYTFLFLYLENLGASNTLLGALW 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 271 TAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIG-SSFATTAAEVVALKMLHAL 329
Cdd:pfam12832 243 ALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLyAFFVENPWLVLPIQFLHAI 302
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-403 |
3.49e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.89 E-value: 3.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 32 FPFLPIWLSDvIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKhlmWIVTVLLVLIAPFFLYVFApllkTNIWLG 111
Cdd:cd17325 16 IPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR---LLLLGLLLLAVSTLLFAFA----TSYWQL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 112 ALSgGAYIGFVFSAGAGAMEAYIERVS--RNSGFEYGKARTFGCLGWALCATTAGMLFS-INPEWVFWMGSAAALLLVVL 188
Cdd:cd17325 88 LLA-RFLQGLASAAVWPAAMALIADIAppEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 189 VAIAKPQASQSAqvmdSLGANRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFATFFKSFFAtpeAGTRAFGF 268
Cdd:cd17325 167 ALLLLPEPRPPP----NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG---LSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 269 ATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALEVPFLLVGAFKYITGVFDV 348
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 518535583 349 RLSATIYLVgFQFAKQVAAIFLSAFAGNMYDRIGFQDTYMILGGIALTVTLISAF 403
Cdd:cd17325 320 EGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
34-406 |
3.99e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.83 E-value: 3.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 34 FLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISD----KLGLKKHLMWIVTVLLVLIAPFFLYVFAPLLKTNIW 109
Cdd:COG2211 32 YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLALSFVLLFTAPDLSPTGKLI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 110 LGALSGGAYiGFVFSAGAGAMEAYIERVS-----RNSGFEYgkARTFGCLGWALCATTAGMLFSI----NPEWVFWMGSA 180
Cdd:COG2211 112 YALVTYLLL-GLAYTLVNIPYSALGAELTpdyeeRTRLSSW--RFAFAGLGGLLASVLPPPLVAAfggdAALGYRLTALI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 181 AALLLVVLVAIAkpqasqSAQVMDSLGANRPAIDLKTAVR-MFRQRKMWMFILYVIGVACVYDVFDQQFATFFKSFFATP 259
Cdd:COG2211 189 FAVLGLLAFLLT------FFGTKERPVPEEEKVSLKESLKaLLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 260 EAgtrAFGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFA--TTAAEVVALKMLHALEVPFLLVG 337
Cdd:COG2211 263 AA---LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVL 339
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518535583 338 AFKYITGVFDVRLSAT------IYLVGFQFAKQVAAIFLSAFAGNMYDRIGFQ----DTYMILGGIALTVTLISAFTLA 406
Cdd:COG2211 340 PWAMLADVVDYDEWKTgrrregLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaQSPSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-317 |
1.26e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 32 FPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKhlmWIVTVLLVLIAPFFLYVFAPLLKTNIWLG 111
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR---VLLIGLLLFALGLLLLLFASSLWLLLVLR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 112 ALSGGAYiGFVFSAGAGAMEAYIERVSRnsGFEYGKARTFGCLGWALCATTAGMLFS-INPEWVFWMGSAAALLLVVLVA 190
Cdd:pfam07690 93 VLQGLGA-GALFPAALALIADWFPPEER--GRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 191 IAKPQASQSAQvmdsLGANRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFATFFKSFFATPEAGTRAFGFAT 270
Cdd:pfam07690 170 LPRPPPESKRP----KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 518535583 271 TAGeicnAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTA 317
Cdd:pfam07690 246 LLG----AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT 288
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-176 |
1.68e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 32 FPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIvtvLLVLIAPFFLYVFApllktNIWLG 111
Cdd:cd17329 19 WPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAG---LLLRALGFALLGFA-----HSPWL 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518535583 112 ALSGGAYIGFVFSAGAGAMEAYIERVSRNSGFEYGKA--RTFGCLGWALCATTAGMLFSINPEWVFW 176
Cdd:cd17329 91 FAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSllYWAINLGVAIGPLLGGLLLLYSFRLLFL 157
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-354 |
1.96e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 33 PFLPiWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWivtVLLVLIAPFFLYVFAPLLKTNIWLGA 112
Cdd:COG2814 31 PALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL---GLLLFALGSLLCALAPSLWLLLAARF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 113 LSGGAyIGFVFSAGAGAMEAYIERVSRNSGFeyGKARTFGCLGWALCATTAGMLFS-INPEWVFWMGSAAALLLVVLVAI 191
Cdd:COG2814 107 LQGLG-AGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 192 AKPQASQSaqvmdslganRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFATFFKSFFATPEAgtrAFGFATT 271
Cdd:COG2814 184 LLPESRPA----------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS---AAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 272 AGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALEVPFLLVGAFKYITGVFDVRLS 351
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR 330
|
...
gi 518535583 352 ATI 354
Cdd:COG2814 331 GRA 333
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
27-403 |
6.25e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 6.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 27 IMATC--FPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKhlmwivtvllVLIAPFFLYVF---A 101
Cdd:cd17473 12 VMAGAaiAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKR----------LLIAGLLLYGIggvA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 102 PLLKTNIWLGALSG---GAYIGFVFSAGAGAMEAYIERVSRNSGFeyGKARTFGCLGWALCATTAGMLFSINPEWVFWM- 177
Cdd:cd17473 82 GLFLDSLYALLASRallGIGVAGIMTLATALIGDYFEGEERAKML--GLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVy 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 178 GSAAALLLVVLVAIAKPQASQSaqvmdslganRPAIDLKTAVRMFRQRKMWMFILYVIGVACVYDVFDQQFATFFKSFFA 257
Cdd:cd17473 160 LLALPVLILVLLFLPEPARKSK----------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 258 TPEAGTrafGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALEVPFLLVG 337
Cdd:cd17473 230 GSAALI---GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPT 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518535583 338 AFKYITGV--FDVRLSATIYLVGFQFAKQVAAIFLSAFAGNMYDriGFQDTYMILGGIALTVTLISAF 403
Cdd:cd17473 307 LNSWAMSLvpPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG--GLSGAFLILGVLALVLAIVLLL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-133 |
1.09e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIvtvLLV 90
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG---LLL 282
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 518535583 91 LIAPFFLYVFAPLLKTNIWLGALSGGAYIGFVFSAGAGAMEAY 133
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
34-118 |
4.02e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 42.49 E-value: 4.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 34 FLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVLLVlIAPFFLYVFAPLLKTNIWLGAL 113
Cdd:cd17337 230 FMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCA-ISTLLFYYVPQLFGHNYWAALI 308
|
....*
gi 518535583 114 SGGAY 118
Cdd:cd17337 309 AAILF 313
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
32-132 |
6.13e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 41.57 E-value: 6.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 32 FPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVLLVLIAPFFLyvfapLLKTNIWLG 111
Cdd:cd17366 213 LSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFL-----LMNSGSIAA 287
|
90 100
....*....|....*....|.
gi 518535583 112 ALSGGAYIGFVFSAGAGAMEA 132
Cdd:cd17366 288 IFIGLLVLGLLLSCYTATMAS 308
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-124 |
6.28e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 6.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 9 KNNPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGlkKHLMWIVTVL 88
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG--KKKAFIIGLL 302
|
90 100 110
....*....|....*....|....*....|....*.
gi 518535583 89 LVLIAPFFLYVFAPLLKTNIWLGALSGGAYIGFVFS 124
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILV 338
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-133 |
1.13e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 13 NFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVLLVLI 92
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 518535583 93 ApFFLYVFAPLLKTNIWLGALSGGAYIGFVFSAGAGAMEAY 133
Cdd:COG2271 261 A-LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
225-406 |
1.15e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 225 RKMWMFILYVIGVACVYDVFDQQFATFFKSFFATPEAGTRA-FGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMV 303
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAqLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 304 MAARMIGSSFATTAAEVVALKMLHALEVPFLLVGAFKYITGVFDVRLSATIYLVgFQFAKQVAAIFLSAFAGNMYDRIGF 383
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGI-FNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180
....*....|....*....|...
gi 518535583 384 QDTYMILGGIALTVTLISAFTLA 406
Cdd:COG2271 164 RAAFLILGLPGLLLALLRFWLLA 186
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-134 |
2.39e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 11 NPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVLLV 90
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 518535583 91 LIAPFFLYVfapllkTNIWLgALSGGAYIGFVFSAGAGAMEAYI 134
Cdd:COG2223 284 GLLLLALAL------GSLWL-FLVLFLLLGLALGGGNGAVFALV 320
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
227-403 |
3.11e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 227 MWMFILYVIGVACVYDVFDQQFATFFKSFFATPEAGTrafGFATTAGEICNAIIMFSSPWIINRIGA--KNTLLIAGMVM 304
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA---GLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 305 AARMIGSSFATTAAEVVALKMLHALEVPFLLVGAFKYITGVFDVRLSATIylVGFQ-FAKQVAAIFLSAFAGNMYDRIGF 383
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTA--SGLVnTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|
gi 518535583 384 QDTYMILGGIALTVTLISAF 403
Cdd:COG2271 337 QAAFLLLAALALLAALLALL 356
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
34-124 |
4.25e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 34 FLPIWLSDVIGLNKTETGLVFSSL-----SLFAICFQPILGVISDKLGLKKHLMWIVTVLLVlIAPFFLYVFAPllkTNI 108
Cdd:COG2270 33 VFPPYFTSVAALGDPAAATALWGYalaiaGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGV-LATAALFFVAP---GGL 108
|
90
....*....|....*..
gi 518535583 109 WLGA-LSGGAYIGFVFS 124
Cdd:COG2270 109 WLGLlLFVLANIGFEGS 125
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
34-317 |
5.05e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.83 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 34 FLPIWLSDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLK--KHLMWIVtVLLVLIAPFFLYVFAPLLKTN---- 107
Cdd:pfam13347 19 YLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRwgRRRPWLL-LSAIILAVSFILLFTPPELGRaplf 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 108 IWLGALSGG---AYIGFVFSAGAGAMEAYIERVSRNSGFEYGkaRTFGCLGWALCATTAGMLFSINPE-------WVFWM 177
Cdd:pfam13347 98 IWLLATYILlriAYTFFEIPYWSLGPELTRDYDERTSLTSYR--SFFSVGGGLLAAALAFPLVLILGGtglerkgYRIFA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 178 GSAAALLLVVLVAIAKPQASQSAQVMDSLGANRPAIDLKTAVR-MFRQRKMWMFILYVIGVACVYDVFDQQFATFFKSFF 256
Cdd:pfam13347 176 LIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKeVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVL 255
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518535583 257 ATPEAGTRAFGFATTAGeicnAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTA 317
Cdd:pfam13347 256 GNGFAASAFPLVFTIGA----LLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPN 312
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
261-405 |
7.48e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 7.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 261 AGTRAFGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIAGMVMAARMIGSSFATTAAEVVALKMLHALEVPFLLVGAFK 340
Cdd:COG2814 42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALA 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518535583 341 YITGVFDVRLSATIYLVgFQFAKQVAAIFLSAFAGNMYDRIGFQDTYMILGGIALTVTLISAFTL 405
Cdd:COG2814 122 LIADLVPPERRGRALGL-LGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-158 |
8.87e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 8.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 9 KNNPNFWIFGLFFFLYFFIMATcFPFLPIWLsDVIGLNKTETGLVFSSLSLFAICFQPILGVISDKLGLKKHLMWIVTVL 88
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGL-LTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLL 275
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535583 89 LVLIAPFFLYVFAPLLKTNIWLGALSGGAYIGFVFSAGAGAMEAYIErvsRNSGFEYGKARTFGCLGWAL 158
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK---EERGTASGLYNTAGSLGGAL 342
|
|
| |
