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Conserved domains on  [gi|518518564|ref|WP_019688771|]
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ornithine carbamoyltransferase [Paenibacillus polymyxa]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479232)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

CATH:  3.40.50.720
EC:  2.1.3.3
Gene Ontology:  GO:0004585|GO:0006591|GO:0006526
PubMed:  18062991

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 11-317 0e+00

ornithine carbamoyltransferase; Provisional


:

Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 611.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  91 QLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGD 170
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 171 GNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAvsrEIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKE 250
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVE---KIAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518518564 251 RELAFADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALI 317
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 11-317 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 611.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  91 QLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGD 170
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 171 GNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAvsrEIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKE 250
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVE---KIAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518518564 251 RELAFADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALI 317
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 10-318 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 608.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  10 VNLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  90 IQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIG 169
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 170 DGNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQK 249
Cdd:COG0078  161 DGNNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518518564 250 ERELAFADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALIG 318
Cdd:COG0078  241 ERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLG 309
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 15-318 4.48e-175

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 486.47  E-value: 4.48e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   15 RDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGR 94
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   95 GEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGDGNNM 174
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  175 AHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKERELA 254
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518518564  255 FADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALIG 318
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
16-155 9.25e-82

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 243.87  E-value: 9.25e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   16 DFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGRG 95
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   96 EPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYE 155
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 11-317 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 611.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  91 QLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGD 170
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 171 GNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAvsrEIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKE 250
Cdd:PRK00779 161 GNNVANSLLLAAALLGFDLRVATPKGYEPDPEIVE---KIAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEE 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518518564 251 RELAFADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALI 317
Cdd:PRK00779 238 RLKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 10-318 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 608.97  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  10 VNLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  90 IQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIG 169
Cdd:COG0078   81 SQLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 170 DGNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQK 249
Cdd:COG0078  161 DGNNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518518564 250 ERELAFADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALIG 318
Cdd:COG0078  241 ERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLG 309
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 15-318 4.48e-175

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 486.47  E-value: 4.48e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   15 RDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGR 94
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   95 GEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGDGNNM 174
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  175 AHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQKERELA 254
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518518564  255 FADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALIG 318
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 10-318 1.71e-171

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 478.61  E-value: 1.71e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  10 VNLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:PRK02102   3 FNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPND 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  90 IQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIG 169
Cdd:PRK02102  83 SQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHFGPLKGLKLAYVG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 170 DG-NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQ 248
Cdd:PRK02102 163 DGrNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGEEDEW 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 249 KERELAFADFQVNEELVKL-AKPDYLFLHCLPA-----------------HRGEEVSAGVIDGPHSVIFDEAENRLHAQK 310
Cdd:PRK02102 243 EERIKLLKPYQVNMDLMKAtGNPDVIFMHCLPAfhdtetkvgkeiaekygLKGLEVTDEVFESKYSIVFDEAENRMHTIK 322


                 ....*...
gi 518518564 311 ALLVALIG 318
Cdd:PRK02102 323 AVMVATLG 330
PLN02342 PLN02342
ornithine carbamoyltransferase
 11-318 2.61e-152

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 430.75  E-value: 2.61e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGE-AYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:PLN02342  42 KSKPKHFLHIDDFDKEEILGLLDRAKEVKALLKSGDrSFQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  90 IQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIG 169
Cdd:PLN02342 122 IQLGKREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIGRLEGTKVVYVG 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 170 DGNNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVavsrEIAKQTG-SEIVITQSPQEAVKDADAIYTDVWASMGFEEEQ 248
Cdd:PLN02342 202 DGNNIVHSWLLLAAVLPFHFVCACPKGYEPDAKTV----EKARAAGiSKIEITNDPAEAVKGADVVYTDVWASMGQKEEA 277

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 249 KERELAFADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALIG 318
Cdd:PLN02342 278 EKRKKAFQGFQVNEALMKLAGPQAYFMHCLPAERGVEVTDGVMEAPNSIVFPQAENRMHAQNAIMLHQLG 347
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 15-318 4.73e-126

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 362.47  E-value: 4.73e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  15 RDFLELDDYSPEEIQYLIDLAIEIKrkhKNGEAY-QPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLG 93
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIK---ANPAEYrQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  94 RGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGDGNN 173
Cdd:PRK14805  79 KRESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFGDVSKVKLAYVGDGNN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 174 MAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITqSPQEAVKDADAIYTDVWASMGFEEEQKEREL 253
Cdd:PRK14805 159 VTHSLMYGAAILGATMTVICPPGHFPDGQIVAEAQELAAKSGGKLVLT-SDIEAIEGHDAIYTDTWISMGDDTPLAEIKA 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518518564 254 AFADFQVNEELVKLAKPDYlFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALIG 318
Cdd:PRK14805 238 KFAPYQVNKALMEKAGATF-VMHCQPAHRGVEITSEVMDGEGSLILQQAENRMHAQNAVLVTLLS 301
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 9-318 9.07e-112

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 327.09  E-value: 9.07e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   9 QVNLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKN 88
Cdd:PRK04284   1 MKNLRNRSFLTLLDFTPKEIEYLLDLSEDLKRAKYAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  89 DIQLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQ-KGKLKGLKLAY 167
Cdd:PRK04284  81 GSQMGKKESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHlKKPYKDIKFTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 168 IGDG-NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEE 246
Cdd:PRK04284 161 VGDGrNNVANALMQGAAIMGMDFHLVCPKELNPDDELLNKCKEIAAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEPD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 247 EQ-KERELAFADFQVNEELVKLAK-PDYLFLHCLPA-H----------------RGEEVSAGVIDGPHSVIFDEAENRLH 307
Cdd:PRK04284 241 EVwEERIKLLKPYQVNKEMMKKTGnPNAIFEHCLPSfHdldtkvgkeifekyglKEMEVTDEVFESKASVVFDEAENRMH 320

                        330
                 ....*....|.
gi 518518564 308 AQKALLVALIG 318
Cdd:PRK04284 321 TIKAVMVATLG 331
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 15-315 8.04e-103

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 304.71  E-value: 8.04e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  15 RDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGR 94
Cdd:PRK03515   7 RHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  95 GEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQ-KGK-LKGLKLAYIGDG- 171
Cdd:PRK03515  87 KESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlPGKaFNEMTLAYAGDAr 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 172 NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQ-KE 250
Cdd:PRK03515 167 NNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEPKEVwAE 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 251 RELAFADFQVNEELVKLA-KPDYLFLHCLPA------------------HRGEEVSAGVIDGPHSVIFDEAENRLHAQKA 311
Cdd:PRK03515 247 RIALLRPYQVNSKMMQLTgNPQVKFLHCLPAfhddqttlgkkmaeeyglHGGMEVTDEVFESAHSIVFDQAENRLHTIKA 326


                 ....
gi 518518564 312 LLVA 315
Cdd:PRK03515 327 VMVA 330
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 11-315 7.73e-92

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 276.48  E-value: 7.73e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:PRK01713   4 NLKNRHLLSLVNHTEREIKYLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  91 QLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGK-LKGLKLAYIG 169
Cdd:PRK01713  84 QIGHKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCDKpLSEISYVYIG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 170 DG-NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFE-EE 247
Cdd:PRK01713 164 DArNNMGNSLLLIGAKLGMDVRICAPKALLPEASLVEMCEKFAKESGARITVTDDIDKAVKGVDFVHTDVWVSMGEPlET 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 248 QKERELAFADFQVNEELVK-LAKPDYLFLHCLPA-HRGE------------------EVSAGVIDGPHSVIFDEAENRLH 307
Cdd:PRK01713 244 WGERIKLLMPYQVTPELMKrTGNPKVKFMHCLPAfHNSEtkvgrqiaekypelangiEVTEDVFESPMNIAFEQAENRMH 323


                 ....*...
gi 518518564 308 AQKALLVA 315
Cdd:PRK01713 324 TIKAVMVA 331
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
16-155 9.25e-82

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 243.87  E-value: 9.25e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   16 DFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGRG 95
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   96 EPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYE 155
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
164-316 6.27e-81

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 242.13  E-value: 6.27e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  164 KLAYIGDG-NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASM 242
Cdd:pfam00185   1 KIAYVGDGhNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIAEKSGGSIEITDDPAEAVKGADVVYTDVWQSM 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518518564  243 GFEEEQKERELAFADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVAL 316
Cdd:pfam00185  81 GQEKEREERLKAFKPYQVNEELMKLAKKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 15-318 2.55e-80

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 247.28  E-value: 2.55e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  15 RDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGR 94
Cdd:PRK12562   7 KHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  95 GEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQ-KGK-LKGLKLAYIGDG- 171
Cdd:PRK12562  87 KESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlPGKaFNEMTLVYAGDAr 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 172 NNMAHSLLIGGAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTGSEIVITQSPQEAVKDADAIYTDVWASMGFEEEQ-KE 250
Cdd:PRK12562 167 NNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSALAQKHGGKITLTEDIAAGVKGADFIYTDVWVSMGEPKEKwAE 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 251 RELAFADFQVNEELVKLA-KPDYLFLHCLPA------------------HRGEEVSAGVIDGPHSVIFDEAENRLHAQKA 311
Cdd:PRK12562 247 RIALLRGYQVNSKMMALTgNPQVKFLHCLPAfhddqttlgkkmakefglHGGMEVTDEVFESPASIVFDQAENRMHTIKA 326


                 ....*..
gi 518518564 312 LLVALIG 318
Cdd:PRK12562 327 VMVATLA 333
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 15-318 1.45e-70

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 222.32  E-value: 1.45e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  15 RDFLELDDYSPEEIQYLIDLAieikRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFL-SKND---I 90
Cdd:PRK04523   4 KHFLNTQDWSRAELDALLTQA----AAFKRNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLqPGKDawpI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  91 QLGRG--------EPISDMAQVMSRYLDGIMIRTFG---------HDNVVE-LARYASVPVINgLSDLAHPCQVLADYQT 152
Cdd:PRK04523  80 EFELGavmdgeteEHIREVARVLSRYVDLIGVRAFPkfvdwskdrQDQVLNsFAKYSTVPVIN-METITHPCQELAHALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 153 LYEQKGK-LKGLKL----AYIGDGNNMA--HSLLIGGAKLGVHVSIASP-AGYEPDPSVVAVSREIAKQTGSEIVITQSP 224
Cdd:PRK04523 159 LQEHFGTtLRGKKYvltwTYHPKPLNTAvaNSALLIATRLGMDVTLLCPtPDYILDERYMDWAEQNAAESGGSLTVSHDI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 225 QEAVKDADAIYTDVWASMG-FEEEQKEREL--AFADFQVNEELVKLAKpDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDE 301
Cdd:PRK04523 239 DSAYAGADVVYAKSWGALPfFGNWEPEKPIrdQYQHFIVDERKMALTN-NGVFSHCLPLRRNVKVTDAVMDSPNCIAIDE 317

                        330
                 ....*....|....*..
gi 518518564 302 AENRLHAQKALLVALIG 318
Cdd:PRK04523 318 AENRLHVQKAIMAALAS 334
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 21-317 1.69e-64

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 206.03  E-value: 1.69e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  21 DDYSPEEIQYLIDLAIEIKRKHKNGEAYqpLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLS--KNDIQLgrgEPI 98
Cdd:PRK14804  13 EDWSDSEILDLLDFAVHVKKNRVNYAGH--MSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDwmASNFQL---SDI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  99 SDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLAHPCQVLADYQTLYEQKGK--LKGLKLAYIGDGNNMAH 176
Cdd:PRK14804  88 DLEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIALDSPEipLNQKQLTYIGVHNNVVN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 177 SLLIGGAKLGVHVSIASPAGYEpdPSVVAVSREIAKQTGSeIVITQSPQEAVKDADAIYTDVWASMGF------EEEQKE 250
Cdd:PRK14804 168 SLIGITAALGIHLTLVTPIAAK--ENIHAQTVERAKKKGT-LSWEMNLHKAVSHADYVYTDTWLDMEFfndpsyADKKKQ 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518518564 251 RELAFADFQVNEELVKlaKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALI 317
Cdd:PRK14804 245 RMELMMPYQINSSLME--KTNAKVMHDMPIHAGYEITREVVLSDRSIIFQQAENRLDAQKAVILKLL 309
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 11-318 2.36e-59

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 192.19  E-value: 2.36e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDI 90
Cdd:COG0540    2 SFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  91 QLGRGEPISDMAQVMSRY-LDGIMIRTfGHDNVV-ELARYASVPVINGlSD--LAHPCQVLADYQTLYEQKGKLKGLKLA 166
Cdd:COG0540   82 SVSKGESLADTIRTLEAYgADAIVIRH-PQEGAArLLAEHVDVPVINA-GDgaHEHPTQALLDLYTIREEFGRLDGLKVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 167 YIGDGNNM--AHSLLIGGAKLGVHVSIASPAGYEPDpsvvavsrEIAKqtgSEIVITQSPQEAVKDADAIY-TDVwasmg 243
Cdd:COG0540  160 IVGDLKHSrvARSNIKALSKLGAEVTLVAPPTLLPE--------EIEE---LGVEVTTDLDEALPDADVVYmLRI----- 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 244 feeeQKER---------ELAFADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLV 314
Cdd:COG0540  224 ----QKERftdglfpsyREYKRSYGLTAERLALAKPDAIVMHPGPRNRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLY 299


                 ....
gi 518518564 315 ALIG 318
Cdd:COG0540  300 LLLG 303
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
11-318 9.93e-54

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 177.96  E-value: 9.93e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQP-LKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:PRK00856   2 PLKMKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKKVPlLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAST 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  90 IQLGRGEPISDMAQVMSRYL-DGIMIRtfgHDN---VVELARYASVPVIN---GLSdlAHPCQVLADYQTLYEQKGKLKG 162
Cdd:PRK00856  82 SSVSKGETLADTIRTLSAMGaDAIVIR---HPQsgaARLLAESSDVPVINagdGSH--QHPTQALLDLLTIREEFGRLEG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 163 LKLAYIGDGNN--MAHSLLIGGAKLGVHVSIASPAGYEPDpsvvavsrEIAKQTgseivITQSPQEAVKDADAIY-TDVw 239
Cdd:PRK00856 157 LKVAIVGDIKHsrVARSNIQALTRLGAEVRLIAPPTLLPE--------GMPEYG-----VHTDLDEVIEDADVVMmLRV- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 240 asmgfeeeQKER-------ELA--FADFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQK 310
Cdd:PRK00856 223 --------QKERmdggllpSYEeyKRSYGLTAERLALAKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRM 294


                 ....*...
gi 518518564 311 ALLVALIG 318
Cdd:PRK00856 295 AVLELLLG 302
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 15-318 5.90e-45

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 154.82  E-value: 5.90e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   15 RDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKND-IQLG 93
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSEtSSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564   94 RGEPISDMAQVMSRYLDGIMIRTfghdNVVELARYAS----VPVIN-GLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYI 168
Cdd:TIGR00670  81 KGETLADTIKTLSGYVDAIVIRH----PLEGAARLAAevseVPVINaGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  169 GDGNN--MAHSLLIGGAKLGVHVSIASpagyepdPSVVAVSREI---AKQTGSEIVITQSPQEAVKDADAIYtdvwasmg 243
Cdd:TIGR00670 157 GDLKYgrTVHSLAEALTRFGVEVYLIS-------PEELRMPKEIleeLKAKGIKVRETESLEEVIDEADVLY-------- 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  244 FEEEQKERELAFAD-------FQVNEELVKLAKPDYLFLHCLPahRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVAL 316
Cdd:TIGR00670 222 VTRIQKERFPDPEEyekvkgsYGITLERLEAAKKGVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALL 299


                  ..
gi 518518564  317 IG 318
Cdd:TIGR00670 300 LG 301
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 24-318 1.50e-28

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 113.81  E-value: 1.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  24 SPEEIQYLIDLAIEIKRKHKNGEAyqpLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALflSKNDIQ---LGRGEPISD 100
Cdd:PRK11891 100 SVEALFRVADVMQPIARRQKISRV---LEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVC--DTTGFTfssMAKGESIYD 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 101 MAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGLSDLA-HPCQVLADYQTL---YEQKGKL-KGLKLAYIGD--GNN 173
Cdd:PRK11891 175 TSRVMSGYVDALVIRHPEQGSVAEFARATNLPVINGGDGPGeHPSQALLDLYTIqreFSRLGKIvDGAHIALVGDlkYGR 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 174 MAHSLLiggaKL-----GVHVSIASPAGYEPDPSVVavsrEIAKQTGSEIVITQSPQEAVKDADAIY-TDVwasmgfeee 247
Cdd:PRK11891 255 TVHSLV----KLlalyrGLKFTLVSPPTLEMPAYIV----EQISRNGHVIEQTDDLAAGLRGADVVYaTRI--------- 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 248 QKER------ELAFADFQVNEELVKLA-KPDYLFLHCLPAHR---GEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALI 317
Cdd:PRK11891 318 QKERfadesfEGYTPDFQINQALVDAVcKPDTLIMHPLPRDSrpgANDLSTDLNRDPRLAIFRQTDNGIPVRMAIFAVLL 397


                 .
gi 518518564 318 G 318
Cdd:PRK11891 398 G 398
PLN02527 PLN02527
aspartate carbamoyltransferase
 16-318 8.87e-28

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 109.84  E-value: 8.87e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  16 DFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFL--SKNDIQLG 93
Cdd:PLN02527   2 DVIEAQQFDREMLELLFEVAREMEKVERGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTenAGEFSSAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  94 RGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVIN-GLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGDGN 172
Cdd:PLN02527  82 KGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATAEIPVINaGDGPGQHPTQALLDVYTIQREIGRLDGIKVGLVGDLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 173 N--MAHSLliggAKL-----GVHVSIASPAGYE-PDPSVVAVSREIAKQTGSEIVItqspqEAVKDADAIYTDVWASMGF 244
Cdd:PLN02527 162 NgrTVRSL----AYLlakyeDVKIYFVAPDVVKmKDDIKDYLTSKGVEWEESSDLM-----EVASKCDVLYQTRIQRERF 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518518564 245 EEEQKERELAFADFQVNEELVKLAKPDYLFLHCLPahRGEEVSAGVIDGPHSVIFDEAENRLHAQKALLVALIG 318
Cdd:PLN02527 233 GERIDLYEAARGKYIVDKKVMDVLPKHAVVMHPLP--RLDEITTDVDSDPRAAYFRQAKNGLFIRMALLKLLLG 304
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 11-292 1.91e-24

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 102.12  E-value: 1.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAiEIKRKHKNGEAYQPLKGKTLGL-IFEKSSTRTRVSFEVGMYQLGGHALFLSKND 89
Cdd:PRK07200  17 HMHEKDFLLTWEKTPDELKAVLDVA-DALRALREENISTKVFNSGLGIsVFRDNSTRTRFSYASACNLLGLEVQDLDEGK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  90 IQLGRGEPISDMAQVMSRYLDGIMIR-------------------TFGHDNVVELARYAsvpVINGLSDLAHPCQVLADY 150
Cdd:PRK07200  96 SQIAHGETVRETANMISFMADVIGIRddmyigkgnaymrevgaavDDGYKQGVLPQRPT---LVNLQCDIDHPTQSMADL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 151 QTLYEQKG---KLKGLKLAYigdgnNMAHSL-----------LIG-GAKLGVHVSIASPAGYEPDPSVVAVSREIAKQTG 215
Cdd:PRK07200 173 LHLIEHFGgleNLKGKKIAM-----TWAYSPsygkplsvpqgIIGlMTRFGMDVTLAHPEGYDLMPEVVEVAKKNAKASG 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 216 SEIVITQSPQEAVKDADAIYTDVWASMGFEEEQK--------------EREL-----AFADFQVNEELVKLAKP-DYLFL 275
Cdd:PRK07200 248 GSFRQVNSMEEAFKDADIVYPKSWAPYKVMEERTelyragdhegikalEKELlaqnaQHKDWHCTEEMMKLTKDgKALYM 327

                        330       340
                 ....*....|....*....|...
gi 518518564 276 HCLPAH------RGEEVSAGVID 292
Cdd:PRK07200 328 HCLPADisgvscKEGEVTESVFD 350
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 11-318 1.14e-20

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 90.56  E-value: 1.14e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  11 NLKGRDFLELDDYSPEEIQYLIDLAIEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHAL----FLS 86
Cdd:PRK08192   2 QFQGSHILSVNQLDRDAIQRIFNVADRMEPYALREKRTRVLEGAILGNLFFEPSTRTRVSFGCAFNLLGGHVRettgMAS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  87 KNdiqLGRGEPISDMAQVMSRYLDGIMIRTFGHDNVVELARYASVPVINGlSDLA--HPCQVLADYQTLYEQ---KGK-L 160
Cdd:PRK08192  82 SS---LSKGESLYDTARVLSTYSDVIAMRHPDAGSVKEFAEGSRVPVING-GDGSneHPTQALLDLFTIQKElahAGRgI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 161 KGLKLAYIGDGNN--MAHSL--LIGGAKlGVHVSIASPAGYE-PDPSVVAVSreiakQTGSEIVITQSPQEAVKDADAIY 235
Cdd:PRK08192 158 DGMHIAMVGDLKFgrTVHSLsrLLCMYK-NVSFTLVSPKELAmPDYVISDIE-----NAGHKITITDQLEGNLDKADILY 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 236 tdvwaSMGFEEE----QKERELAFADFQVNEEL-VKLAKPDYLFLHCLPA-HRGE--EVSAGVIDGPHSVIFDEAENRLH 307
Cdd:PRK08192 232 -----LTRIQEErfpsQEEANKYRGKFRLNQSIyTQHCKSNTVIMHPLPRdSRAQanELDNDLNSHPNLAIFRQADNGLL 306

                        330
                 ....*....|.
gi 518518564 308 AQKALLVALIG 318
Cdd:PRK08192 307 IRMALFALTLG 317
pyrB PRK13814
aspartate carbamoyltransferase;
17-313 1.15e-14

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 73.21  E-value: 1.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  17 FLELDDYSPEEIQYLIDLA-IEIKRKHKNGEAYQPLKGKTLGLIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDIQLGRG 95
Cdd:PRK13814   8 LLNMRSLTRDHIEKLIQRAnYFLTQGMEKNSVFETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISKG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564  96 EPISDMA---QVMSRYLdgIMIRTFGHDNVVELARYASVPVI--NGLSDLAHPCQVLADYQTLYEQKGKLKGLKLAYIGD 170
Cdd:PRK13814  88 ETLFDTIktlEAMGVYF--FIVRHSENETPEQIAKQLSSGVVinAGDGNHQHPSQALIDLMTIKQHKPHWNKLCVTIIGD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 171 --GNNMAHSLLIGGAKLGV-HVSIASPAGYEPDP----SVVAVSREIAKQTGSEIVITQSPQEAVKDADaiyTDVWASMG 243
Cdd:PRK13814 166 irHSRVANSLMDGLVTMGVpEIRLVGPSSLLPDKvgndSIKKFTELKPSLLNSDVIVTLRLQKERHDNS---VDIDAFRG 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518564 244 feeeqkerelafaDFQVNEELVKLAKPDYLFLHCLPAHRGEEVSAGVIDGPHSVIFDEAENRLHAQKALL 313
Cdd:PRK13814 243 -------------SFRLTPEKLYSAKPDAIVMHPGPVNREVEINSDVADNQQSVILQQVRNGVAMRMAVL 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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