NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|517234233|ref|WP_018423051|]
View 

MULTISPECIES: ACT domain-containing protein [Paraburkholderia]

Protein Classification

ACT domain-containing protein( domain architecture ID 11466470)

ACT domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ACT-3 COG3602
ACT domain, ACT-3 family [Signal transduction mechanisms];
1-135 2.89e-64

ACT domain, ACT-3 family [Signal transduction mechanisms];


:

Pssm-ID: 442821 [Multi-domain]  Cd Length: 135  Bit Score: 191.95  E-value: 2.89e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517234233   1 MSqPVSDLAQLLASMQPELNEGAYVFSSVLADR-DVSQLAPLATFREREGLTVIIDEPTALREGLPVLFRAAWITLNVHS 79
Cdd:COG3602    1 MS-GETDLDELLASMTPVLNPGEYVFCTLPADQlPALELEPLATFREAEGLTLVLPRETADAAGLPYSFPFRWITLTVHS 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 517234233  80 DLEAVGLTAAVADALTRACISCNVVAAAFHDHIFVPVERARDALAQLTDLQARAGQ 135
Cdd:COG3602   80 SLEAVGLTAAVATALAEAGISCNVVAAYYHDHIFVPEDDAEQALAVLEALSAAAKA 135
 
Name Accession Description Interval E-value
ACT-3 COG3602
ACT domain, ACT-3 family [Signal transduction mechanisms];
1-135 2.89e-64

ACT domain, ACT-3 family [Signal transduction mechanisms];


Pssm-ID: 442821 [Multi-domain]  Cd Length: 135  Bit Score: 191.95  E-value: 2.89e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517234233   1 MSqPVSDLAQLLASMQPELNEGAYVFSSVLADR-DVSQLAPLATFREREGLTVIIDEPTALREGLPVLFRAAWITLNVHS 79
Cdd:COG3602    1 MS-GETDLDELLASMTPVLNPGEYVFCTLPADQlPALELEPLATFREAEGLTLVLPRETADAAGLPYSFPFRWITLTVHS 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 517234233  80 DLEAVGLTAAVADALTRACISCNVVAAAFHDHIFVPVERARDALAQLTDLQARAGQ 135
Cdd:COG3602   80 SLEAVGLTAAVATALAEAGISCNVVAAYYHDHIFVPEDDAEQALAVLEALSAAAKA 135
ACT_3 pfam10000
ACT domain; This domain, found in various hypothetical bacterial proteins, has no known ...
 6-70 4.68e-20

ACT domain; This domain, found in various hypothetical bacterial proteins, has no known function. However, its structure is similar to the ACT domain which suggests that it binds to amino acids and regulates other protein activity. This family was formerly known as DUF2241.


Pssm-ID: 430977  Cd Length: 69  Bit Score: 77.99  E-value: 4.68e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517234233    6 SDLAQLLASMQPELNEGAYVFSSV-LADRDVSQLAPLATFREREGLTVIIDEPTALREGLPVLFRA 70
Cdd:pfam10000   4 TDLDTLLATMTPELNPGTYVFCTLpDALADPLGLPPLATFREAEGLTLILPREEADAAGLDYDFPA 69
PRK05222 PRK05222
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional
 46-72 2.92e-03

5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional


Pssm-ID: 235367 [Multi-domain]  Cd Length: 758  Bit Score: 36.63  E-value: 2.92e-03
                         10        20
                 ....*....|....*....|....*...
gi 517234233  46 EREGLTVI-IDEPtALREGLPvLFRAAW 72
Cdd:PRK05222 591 EAAGIKIIqIDEP-ALREGLP-LRRSDW 616
 
Name Accession Description Interval E-value
ACT-3 COG3602
ACT domain, ACT-3 family [Signal transduction mechanisms];
1-135 2.89e-64

ACT domain, ACT-3 family [Signal transduction mechanisms];


Pssm-ID: 442821 [Multi-domain]  Cd Length: 135  Bit Score: 191.95  E-value: 2.89e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517234233   1 MSqPVSDLAQLLASMQPELNEGAYVFSSVLADR-DVSQLAPLATFREREGLTVIIDEPTALREGLPVLFRAAWITLNVHS 79
Cdd:COG3602    1 MS-GETDLDELLASMTPVLNPGEYVFCTLPADQlPALELEPLATFREAEGLTLVLPRETADAAGLPYSFPFRWITLTVHS 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 517234233  80 DLEAVGLTAAVADALTRACISCNVVAAAFHDHIFVPVERARDALAQLTDLQARAGQ 135
Cdd:COG3602   80 SLEAVGLTAAVATALAEAGISCNVVAAYYHDHIFVPEDDAEQALAVLEALSAAAKA 135
ACT_3 pfam10000
ACT domain; This domain, found in various hypothetical bacterial proteins, has no known ...
 6-70 4.68e-20

ACT domain; This domain, found in various hypothetical bacterial proteins, has no known function. However, its structure is similar to the ACT domain which suggests that it binds to amino acids and regulates other protein activity. This family was formerly known as DUF2241.


Pssm-ID: 430977  Cd Length: 69  Bit Score: 77.99  E-value: 4.68e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517234233    6 SDLAQLLASMQPELNEGAYVFSSV-LADRDVSQLAPLATFREREGLTVIIDEPTALREGLPVLFRA 70
Cdd:pfam10000   4 TDLDTLLATMTPELNPGTYVFCTLpDALADPLGLPPLATFREAEGLTLILPREEADAAGLDYDFPA 69
ACT_7 pfam13840
ACT domain; The ACT domain is a structural motif of 70-90 amino acids that functions in the ...
 72-128 1.40e-07

ACT domain; The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding.


Pssm-ID: 433519 [Multi-domain]  Cd Length: 65  Bit Score: 45.60  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 517234233   72 WITLNVHS---DLEAVGLTAAVADALTRACISCNVVAAAFHDHIFVPVERARDALAQLTD 128
Cdd:pfam13840   6 WAKLSVVGaglDFDVPGVVAKLTSPLAEAGISIFQISSYTTDYVLVPEEDLEKAVRALHE 65
PRK05222 PRK05222
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional
 46-72 2.92e-03

5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional


Pssm-ID: 235367 [Multi-domain]  Cd Length: 758  Bit Score: 36.63  E-value: 2.92e-03
                         10        20
                 ....*....|....*....|....*...
gi 517234233  46 EREGLTVI-IDEPtALREGLPvLFRAAW 72
Cdd:PRK05222 591 EAAGIKIIqIDEP-ALREGLP-LRRSDW 616
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH